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https://www.readbyqxmd.com/read/28811779/effect-of-exercise-and-morphine-on-psychological-and-physical-dependencies-bdnf-and-trkb-gene-expression-in-rat-s-hippocampus
#1
Mojtaba Naghshvarian, Mohammad-Reza Zarrindast, Shahram Ejtemaei Mehr, Mohammad Mehdi Ommati, Seyedeh Fatemeh Sajjadi
OBJECTIVES: To compare the effect of exercise and morphine on abstinence syndrome and hippocampal gene expression in rat model. METHODS: Thirty adult male rats were exposed to voluntary wheel exercise (low, medium, high) for 28 days. The subjects entered Conditioned Place Preference (CPP) apparatus and experienced morphine (low, medium, high) CPP and followed by naloxone test. Correlation between exercise level, morphine injection, concurrent morphine administration and exercise with morphine CPP, BDNF and TrkB genes was determined...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28804609/therapeutic-effects-of-ellagic-acid-on-memory-hippocampus-electrophysiology-deficits-and-elevated-tnf-%C3%AE-level-in-brain-due-to-experimental-traumatic-brain-injury
#2
Shahram Mashhadizadeh, Yaghoub Farbood, Mahin Dianat, Ali Khodadadi, Alireza Sarkaki
OBJECTIVES: Cognitive defects such as learning and memory impairment are amongst the most repetitious sequelae after sever and moderate traumatic brain injury (TBI). It was suggested that ellagic acid (EA), an innate phenol product, display neuroprotective properties against oxidative and inflammatory damages after brain injury. The object of the current study was therapeutic properties of EA on blood-brain barrier (BBB) interruption and elevated content of TNF-α in brain tissue followed by neurologic aftereffects, cognitive and brain electrophysiology deficits as outcomes of diffuse TBI in rat...
April 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28803720/impact-of-the-self-care-education-program-on-quality-of-life-in-patients-with-type-ii-diabetes
#3
Shahram Baraz, Kourosh Zarea, Hajiee Bibi Shahbazian
INTRODUCTION: Diabetes is an irreversible disease requiring lifetime self-care and rehabilitation. Patient education to improve their ability in administering self-care is also effective, lowering the risks of developing complications and promoting the quality of life. This study was conducted to assess the effect of self-care educational programs in promoting the quality of life of diabetic patients. METHODS: In this pre-test/post-test intervention study design, 30 diabetes patients were included on the basis of a non-randomized sampling, using each subject as her/his own control...
August 1, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28800869/the-role-of-ca3-gabab-receptors-on-anxiolytic-like-behaviors-and-avoidance-memory-deficit-induced-by-d-ap5-with-respect-to-ca-2-ions
#4
Shahram Zarrabian, Mohammad Nasehi, Maryam Farrahizadeh, Mohammad-Reza Zarrindast
Glutamatergic and GABAergic systems play key roles in the hippocampus and affect the pathogenesis of anxiety- and memory-related processes. Some investigations have assessed the role of balancing the function of these two systems in different areas of the central nervous system (CNS) as an approach to manage the related disorders. We investigated the anxiety and avoidance memory states using the test-retest protocol in the elevated plus maze to understand the role of GABAB receptors (GABABRs) in relation to the NMDA receptor blockade by D-AP5 (an NMDA receptor antagonist)...
August 8, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28795056/heart-rate-beat-to-beat-variability-of-trauma-patient-in-neurogenic-shock-state-time-to-introduce-new-symptoms
#5
EDITORIAL
Shahram Paydar, Mohammad Yasin Karami, Hosseinali Khalili, Maryam Dehghankhalili, Golnar Sabetian, Fariborz Ghaffarpasand
No abstract text is available yet for this article.
July 2017: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/28791490/secretases-related-mirnas-in-alzheimer-s-disease-new-approach-for-biomarker-discovery
#6
REVIEW
Seyedeh Nazanin Hajjari, Mehdi Mehdizadeh, Saeed Sadigh-Eteghad, Dariush Shanehbandi, Shahram Teimourian, Behzad Baradaran
Amyloid-β (Aβ) as a crucial factor in pathogenesis of Alzheimer's disease (AD) is derived from amyloid precursor protein (APP) through a proteolytic process catalyzing by β- and γ-secretase-in amyloidogenesis pathway. Products of α-secretase cleavage also have protective effects against Aβ toxicity. According to existing evidences, microRNAs (miRNAs) show a unique pattern of expression in AD. Moreover, miRNAs regulatory effects on expression of secretases and their main components have been demonstrated in AD...
August 8, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28791056/accuracy-of-different-topographic-instruments-in-calculating-corneal-power-after-myopic-photorefractive-keratectomy
#7
Alireza Baradaran-Rafii, Sahba Fekri, Mohammad Rezaie, Shahram Salehi-Rad, Ali Moradi, Tahmineh Motevasseli, Masumeh Kalantarion
PURPOSE: To compare the corneal power measurements obtained using different topographic instruments after myopic photorefractive keratectomy (PRK). METHODS: Patients with myopia who were candidates for corneal refractive surgery were sequentially included. Pre-PRK and six months post-PRK corneal powers were measured using Javal manual keratometer, Orbscan II, Galilei, Tomey TMS4, and EyeSys 2000 topographers. Measured values were compared with those obtained using the clinical history method (CHM)...
July 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28783666/dynamics-of-influenza-induced-lung-resident-memory-t-cells-underlie-waning-heterosubtypic-immunity
#8
Bram Slütter, Natalija Van Braeckel-Budimir, Georges Abboud, Steven M Varga, Shahram Salek-Ardakani, John T Harty
Lung-resident memory CD8 T cells (TRM) induced by influenza A virus (IAV) that are pivotal for providing subtype-transcending protection against IAV infection (heterosubtypic immunity) are not maintained long term, causing gradual loss of protection. The short-lived nature of lung TRM contrasts sharply with long-term maintenance of TRM induced by localized infections in the skin and in other tissues. We show that the decline in lung TRM is determined by an imbalance between apoptosis and lung recruitment and conversion to TRM of circulating memory cells...
January 6, 2017: Science Immunology
https://www.readbyqxmd.com/read/28782832/aav-delivery-of-grp78-bip-promotes-adaptation-of-human-rpe-cell-to-er-stress
#9
Shima Ghaderi, Shahin Ahmadian, Zahra-Soheila Soheili, Hamid Ahmadieh, Shahram Samiei, Samira Kheitan, Ehsan Ranaei Pirmardan
Adeno associated virus (AAV)-mediated gene delivery of GRP78 (78kDa glucose-regulated protein) attenuates the condition of endoplasmic reticulum (ER) stress and prevents apoptotic loss of photoreceptors in retinitis pigmentosa (RP) rats. In the current study we overexpressed Grp78 with the help of AAV-2 in primary human retinal pigmented epithelium (hRPE) cell cultures and examined its effect on cell response to ER stress. The purpose of this work was studying potential stimulating effect of GRP78 on adaptation/pro-survival of hRPE cells under ER stress, as an in vitro model for RPE degeneration...
August 7, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28777422/the-use-of-streptokinase-for-restoration-of-patency-to-hemodialysis-central-venous-catheters-a-low-cost-safe-and-effective-option
#10
Bahman Bashardoust, Shahram Habibzadeh, Afshan Sharghi, Raheleh Eskandari, Nasrollah Maleki
No abstract text is available yet for this article.
July 26, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28768846/clinical-phenotype-and-outcome-of-hepatitis-e-virus-associated-neuralgic-amyotrophy
#11
Jeroen J J van Eijk, Harry R Dalton, Paolo Ripellino, Richard G Madden, Catherine Jones, Miriam Fritz, Claudio Gobbi, Giorgia Melli, Emanuela Pasi, Jenny Herrod, Rebecca F Lissmann, Hamad H Ashraf, Mohamed Abdelrahim, Omar A B A L Masri, Montserrat Fraga, David Benninger, Thierry Kuntzer, Vincent Aubert, Roland Sahli, Darius Moradpour, Hélène Blasco-Perrin, Shahram Attarian, Rene Gérolami, Philippe Colson, Maria T Giordani, Johannes Hartl, Sven Pischke, Nan X Lin, Brendan N Mclean, Richard P Bendall, Marcus Panning, Jean-Marie Peron, Nassim Kamar, Jacques Izopet, Bart C Jacobs, Nens van Alfen, Baziel G M van Engelen
OBJECTIVE: To determine the clinical phenotype and outcome in hepatitis E virus-associated neuralgic amyotrophy (HEV-NA). METHODS: Cases of NA were identified in 11 centers from 7 European countries, with retrospective analysis of demographics, clinical/laboratory findings, and treatment and outcome. Cases of HEV-NA were compared with NA cases without evidence of HEV infection. RESULTS: Fifty-seven cases of HEV-NA and 61 NA cases without HEV were studied...
August 2, 2017: Neurology
https://www.readbyqxmd.com/read/28768190/bmp4-gene-therapy-in-mature-mice-reduces-bat-activation-but-protects-from-obesity-by-browning-subcutaneous-adipose-tissue
#12
Jenny M Hoffmann, John R Grünberg, Christopher Church, Ivet Elias, Vilborg Palsdottir, John-Olov Jansson, Fatima Bosch, Ann Hammarstedt, Shahram Hedjazifar, Ulf Smith
We examined the effect of Bone Morphogenetic Protein 4 (BMP4) on energy expenditure in adult mature mice by targeting the liver with adeno-associated viral (AAV) BMP4 vectors to increase circulating levels. We verified the direct effect of BMP4 in inducing a brown oxidative phenotype in differentiating preadipocytes in vitro. AAV-BMP4-treated mice display marked browning of subcutaneous adipocytes, with increased mitochondria and Uncoupling Protein 1 (UCP1). These mice are protected from obesity on a high-fat diet and have increased whole-body energy expenditure, improved insulin sensitivity, reduced liver fat, and reduced adipose tissue inflammation...
August 1, 2017: Cell Reports
https://www.readbyqxmd.com/read/28767477/a-simple-and-effective-way-to-secure-a-laryngeal-mask-airway-mask-in-place
#13
Shahram Shokohi, Mir Mousa Aghdashi
No abstract text is available yet for this article.
August 1, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28761886/balancing-power-a-grounded-theory-study-on-partnership-of-academic-service-institutes
#14
Fatemeh Heshmati Nabavi, Zohreh Vanaki, Eesa Mohammadi, Shahram Yazdani
INTRODUCTION: Governments and professional organizations have called for new partnerships between health care providers and academics to improve clinical education for the benefit of both students and patients. To develop a substantive grounded theory on the process of forming academic-service partnerships in implementing clinical education, from the perspective of academic and clinical nursing staff members and managers working in Iranian settings. METHODS: The participants included 15 hospital nurses, nurse managers, nurse educators, and educational managers from two central universities and clinical settings from 2009 to 2012...
July 2017: Journal of Advances in Medical Education & Professionalism
https://www.readbyqxmd.com/read/28761884/social-accountable-medical-education-a-concept-analysis
#15
Mohammadreza Abdolmaleki, Shahram Yazdani, Sedigheh Momeni, Nader Momtazmanesh
INTRODUCTION: Considering the pervasiveness of social accountable medical education concept around the world and the growing trend of literature in this regard as well as various interpretations made about this concept, we found it necessary to analyze the concept of social accountable medical education. METHODS: In this study, the modified version of McKenna's approach to concept analysis was used to determine the concept, explain structures and substructures and determine the border concepts neighboring and against social accountability in medical education...
July 2017: Journal of Advances in Medical Education & Professionalism
https://www.readbyqxmd.com/read/28761650/pioglitazone-and-risk-of-mortality-in-patients-with-type-2-diabetes-results-from-a-european-multidatabase-cohort-study
#16
Helen Strongman, Pasi Korhonen, Rachael Williams, Shahram Bahmanyar, Fabian Hoti, Solomon Christopher, Maila Majak, Leanne Kool-Houweling, Marie Linder, Paul Dolin, Edith M Heintjes
OBJECTIVES: Estimate and compare the risk of mortality in patients whose antidiabetic therapy is modified to include pioglitazone compared with an alternative antidiabetic medication at the same stage of disease progression. DESIGN: Retrospective cohort study. SETTING: Pooled analysis of clinical data collected from primary and/or secondary care settings in four European countries: Finland, The Netherlands, Sweden and the UK . PARTICIPANTS: 56 337 patients with type 2 diabetes mellitus first prescribed pioglitazone between 2000 and 2011, and 56 337 patients never prescribed pioglitazone matched by treatment stage, history of diabetes, diabetes complications and cardiovascular disease, and year of cohort entry using exact and propensity score matching...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761467/prevalence-of-intestinal-protozoa-infections-and-associated-risk-factors-among-schoolchildren-in-sanandaj-city-iran
#17
Pegah Bahmani, Afshin Maleki, Shahram Sadeghi, Behzad Shahmoradi, Esmaeil Ghahremani
BACKGROUND: Intestinal parasites are still a serious public health problem in the world, especially in developing countries. This study aimed to assess the prevalence of intestinal protozoa infections and associated risk factors among schoolchildren in Sanandaj City, Iran. METHODS: This cross-sectional study involving 400 schoolchildren was carried out in 2015. Each student was selected using systematic random sampling method. Questionnaire and observation were used to identify possible risk factors...
January 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28754214/a-systematic-review-and-meta-analysis-of-the-prevalence-of-leishmania-infection-in-blood-donors
#18
REVIEW
Masoud Foroutan, Sahar Dalvand, Shahram Khademvatan, Hamidreza Majidiani, Hamidreza Khalkhali, Sajjad Masoumifard, Gebraeil Shamsaddin
BACKGROUND: The risk of transfusion transmitted leishmaniasis (TTL) from apparently healthy persons or asymptomatic individuals, should not be ignored. Lack of a comprehensive review, encouraged us to design a systematic review with meta-analysis approach to assess the prevalence of Leishmania infection in healthy blood donors. METHODS: For this purpose, 6 English databases (PubMed, Scopus, Web of Sciences, Science Direct, EMBASE and CINAHL) were browsed from January 1990 to July 2016...
July 11, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28752802/three-dimensional-wet-electrospun-poly-lactic-acid-multi-wall-carbon-nanotubes-scaffold-induces-differentiation-of-human-menstrual-blood-derived-stem-cells-into-germ-like-cells
#19
Hossein Eyni, Sadegh Ghorbani, Reza Shirazi, Leila Salari Asl, Shahram P Beiranvand, Masoud Soleimani
Infertility caused by the disruption or absence of germ cells is a major and largely incurable medical problem. Germ cells (i.e., sperm or egg) play a key role in the transmission of genetic and epigenetic information across generations. Generation of gametes derived in vitro from stem cells hold promising prospects which could potentially help infertile men and women. Menstrual blood-derived stem cells are a unique stem cell source. Evidence suggests that menstrual blood-derived stem cells exhibit a multi-lineage potential and have attracted extensive attention in regenerative medicine...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28747914/extrinsic-protein-tyrosine-phosphatase-non-receptor-22-signals-contribute-to-cd8-t-cell-exhaustion-and-promote-persistence-of-chronic-lymphocytic-choriomeningitis-virus-infection
#20
Tatiana Jofra, Giuseppe Galvani, Mirela Kuka, Roberta Di Fonte, Bechara G Mfarrej, Matteo Iannacone, Shahram Salek-Ardakani, Manuela Battaglia, Georgia Fousteri
A genetic variant of the protein tyrosine phosphatase non-receptor 22 (PTPN22) is associated with a wide range of autoimmune diseases; however, the reasons behind its prevalence in the general population remain not completely understood. Recent evidence highlights an important role of autoimmune susceptibility genetic variants in conferring resistance against certain pathogens. In this study, we examined the role of PTPN22 in persistent infection in mice lacking PTPN22 infected with lymphocytic choriomeningitis virus clone 13...
2017: Frontiers in Immunology
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