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Seyed Nezamedin Hosseini, Parisa Ghaisari, Shahram Sharifnia, Maryam Khatami, Amin Javidanbardan
In the downstream process of recombinant hepatitis B surface antigen (rHBsAg), nano-colloidal silica adsorbent (Aerosil-380) is one of the possible methods to separate the antigen from other main impurities partially. The current study aimed to maximize the adsorptive capacity of Aerosil-380 as well as rHBsAg recovery for large-scale production of recombinant hepatitis B vaccine. The experimental design methodology was used to optimize the eight critical parameters influencing the efficiency, rHBsAg recovery, of the adsorption-desorption process in the lab-scale...
June 22, 2018: Preparative Biochemistry & Biotechnology
Fatemeh Darsareh, Teamur Aghamolaei, Minoo Rajaei, Abdoulhossain Madani, Shahram Zare
PROBLEM: The steep increase and inappropriateness of caesarean birth represent a healthcare problem in Iran. AIM: The purpose of study was to evaluate the effect of a campaign based on social marketing to promote normal childbirth. METHOD: The study was designed as a prospective case control study. The social marketing campaign was implemented from March 2016 to January 2017. A demographic data questionnaire, obstetrical history questionnaire, maternal knowledge assessment questionnaire, and maternal health belief questionnaire comprised the instruments for this study...
June 18, 2018: Women and Birth: Journal of the Australian College of Midwives
Mohsen Saeb, Daryoush Shahbazi-Gahrouei, Shahram Monadi
Background: This study aimed to evaluate the overall accuracy of the beam commissioning criteria of targeted image-guided radiation therapy (TiGRT) treatment planning system (TPS) based on the American Association of Physicists in Medicine (AAPM) Task Group Report 119 (TG-119). Methods: The work was performed using 6 MV energy LINAC with a variable dose rate of 200 MU/min which equipped with the high-quality external TiGRT dynamic multileaf collimator model H. The AAPM TG-119 intensity-modulated radiation therapy (IMRT) commissioning tests are composed of two preliminary tests and four clinical test cases...
April 2018: Journal of Medical Signals and Sensors
Shahram Akhlaghpoor, Pooya Torkian, Jafar Golzarian
BACKGROUND: Large hepatic hemangiomas can cause symptoms such as pain and bleeding. No consensus currently exists on the optimal management of large and symptomatic hemangiomas. The purpose of this study was to evaluate the role of transarterial bleomycin-lipiodol embolization (B/LE) in the treatment of symptomatic large hepatic hemangioma. MATERIALS AND METHODS: We retrospectively reviewed 23 patients (29 hemangiomas) treated between July 2011 and August 2017. Transarterial B/LE was performed using 7-15 cc of Lipiodol mixed with 30-45 IU of bleomycin by standard three-way stopcocks...
June 19, 2018: Cardiovascular and Interventional Radiology
Soleiman Ahmady, Shahram Yazdani, Fakhrolsadat Hosseini, Mohammad Mehdi Forouzanfar, Ali Tabibi, Fatemeh Ahmadinia, Hoda Ahmari Tehran, Noushin Kohan, Heidar Mohammadi
PURPOSE: It is essential to adjust the responsibilities and function of medical education offices (MEOs) in regard to the current societal requirements. Therefore, it is a good idea to learn lessons from the experiences about the establishment and function of these offices around the world. The aim of the present study was to carry out a comparative study to investigate the function and structure of MEOs at some of the medical universities from America, Europe, and Asia. SUBJECTS AND METHODS: This is a comparative, descriptive study that was conducted in 2015...
2018: Journal of Education and Health Promotion
Emad Kordbacheh, Shahram Nazarian, Davoud Sadeghi, Abbas Hajizadeh
Objectives: Enterotoxigenic Escherichia coli (ETEC) is known as the most common bacterial causes of diarrheal diseases related to morbidity and mortality. Heat-labile enterotoxin (LT) is a part of major virulence factors in ETEC pathogenesis. Antigen entrapment into nanoparticles (NPs) can protect them and enhance their immunogenicity. Materials and Methods: In the present study, recombinant LTB protein was expressed in E. coli BL21 (DE3) and purified by an Ni-NTA agarose column...
May 2018: Iranian Journal of Basic Medical Sciences
Mohammed Alhaidar, Mohanad Algaeed, Richard Amdur, Rami Algahtani, Shahram Majidi, Dimitri Sigounas, Christopher R Leon Guerrero
Background: Carotid endarterectomy (CEA) and carotid artery stenting (CAS) are both viable treatment options for carotid artery stenosis. We sought to compare perioperative outcomes after CEA and CAS for the management of carotid stenosis using a "real-world" sample. Methods: We conducted a retrospective observational study using the National Surgical Quality Improvement Program database to compare 30-day (periprocedural) outcomes in patients with carotid stenosis undergoing CEA versus CAS from 2005 to 2012...
June 2018: Journal of Vascular and Interventional Neurology
Preet Kaur Sahota, Siri Shastry, Dana B Mukamel, Linda Murphy, Narisu Yang, Shahram Lotfipour, Bharath Chakravarthy
INTRODUCTION: The opioid drug epidemic is a major public health concern and an economic burden in the United States. The purpose of this systematic review is to assess the reliability and validity of screening instruments used in emergency medicine settings to detect opioid use in patients and to assess psychometric data for each screening instrument. METHODS: PubMed/MEDLINE, PsycINFO, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Web of Science, Cumulative Index to Nursing and Allied Health Literature and ClinicalTrials...
May 24, 2018: Addictive Behaviors
Arezou Sayad, Abbas Hajifathali, Mir Davood Omrani, Shahram Arsang-Jang, Amir Ali Hamidieh, Mohammad Taheri
Recently, Long noncoding RNAs (lncRNAs) have been described as regulatory factors for several biological mechanisms through regulating the gene expression. Among them the TNF and HNRNPL related immunoregulatory (THRIL) lncRNA may be involved in the pathogenesis of immune-related and inflammatory disease through controlling the expression of the tumor necrosis factor-alpha (TNF-α) expression. In this case-control study, we investigate the THRIL expression in blood 25 samples of de novo acute myeloid leukemia (AML) cases (10 females and 15 males, mean age±SD: 35...
June 2018: Iranian Journal of Allergy, Asthma, and Immunology
Shahram Amini, Hojat Naghavi Robabi, Mohammad Abbasi Tashnizi, Vida Vakili
OBJECTIVE: The aim of this study was to investigate the impact of perioperative administration of N-acetylcysteine, selenium and vitamin C on the incidence and outcomes of acute kidney injury after off-pump coronary bypass graft surgery. METHODS: 291 patients requiring elective off-pump coronary bypass graft surgery were randomized to receive either N-acetylcysteine, vitamin C and selenium 600 mg, 1500 mg, 0.5 mg, and nothing orally twice a day, respectively, from the day before to 2 days after surgery...
March 2018: Brazilian Journal of Cardiovascular Surgery
Shahram Bamdad, Naser Owji, Alireza Bolkheir
PURPOSE: To investigate the possibility of an association between serum levels of zinc (Zn), calcium (Ca), magnesium (Mg), iron (Fe), copper (Cu), and selenium (Se) and advanced keratoconus (KCN). METHODS: In this study, 50 patients with advanced KCN and 50 control subjects were included. Plasma levels of Zn, Ca, Mg, Fe, Cu, and Se were compared between the groups. RESULTS: Mean ± SD age of the patients in the case and control groups was 29...
June 7, 2018: Cornea
Morteza Shahrestani, Mohammad Saber Tehrani, Shahram Shoeibi, Parviz Aberoomand Azar, Syed Waqif Husain
The primary aromatic amines (PAAs) are food contaminants which may exist in packaged food. Polyurethane (PU) adhesives which are used in flexible packaging are the main source of PAAs. It is the unreacted diisocyanates which in fact migrate to foodstuff and then hydrolyze to PAAs. These PAAs include toluenediamines (TDAs) and methylenedianilines (MDAs), and the selected PAAs were 2,4-TDA, 2,6-TDA, 4,4'-MDA, 2,4'-MDA, and 2,2'-MDA. PAAs have genotoxic, carcinogenic, and allergenic effects. In this study, extraction methods were applied on a 3% acetic acid as food simulant which was spiked with the PAAs under study...
2018: Journal of Analytical Methods in Chemistry
Shahram Niknafs, Eugeni Roura
The anatomical structure and function of beaks, bills and tongue together with the mechanics of deglutition in birds have contributed to the development of a taste system denuded of macrostructures visible to the human naked eye. Studies in chickens and other birds have revealed that the avian taste system consists of taste buds not clustered in papillae and located mainly (60 %) in the upper palate hidden in the crevasses of the salivary ducts. That explains the long delay in the understanding of the avian taste system...
June 11, 2018: Nutrition Research Reviews
Florian Krach, Ranjan Batra, Emily C Wheeler, Anthony Q Vu, Ruth Wang, Kasey Hutt, Stuart J Rabin, Michael W Baughn, Ryan T Libby, Sandra Diaz-Garcia, Jennifer Stauffer, Elaine Pirie, Shahram Saberi, Maria Rodriguez, Assael A Madrigal, Zacharias Kohl, Beate Winner, Gene W Yeo, John Ravits
Sporadic amyotrophic lateral sclerosis (sALS) is the most common form of ALS, however, the molecular mechanisms underlying cellular damage and motor neuron degeneration remain elusive. To identify molecular signatures of sALS we performed genome-wide expression profiling in laser capture microdissection-enriched surviving motor neurons (MNs) from lumbar spinal cords of sALS patients with rostral onset and caudal progression. After correcting for immunological background, we discover a highly specific gene expression signature for sALS that is associated with phosphorylated TDP-43 (pTDP-43) pathology...
June 7, 2018: Acta Neuropathologica
Shahram Bamdad, Alireza Bolkheir, Mohammad Reza Sedaghat, Mahsa Motamed
Background: Age-related cataract is a leading cause of visual impairment, considered a global health burden, it is responsible for over 47% of blindness worldwide. Surgical intervention is usually the treatment of choice and phacoemulsification cataract surgery with implantation of an intraocular lens is the most common procedure, which may have several complications. Objectives: To determine the effects of phacoemulsification surgery on corneal endothelial cell density and corneal thickness in patients undergoing cataract surgery...
April 2018: Electronic Physician
Asghar Razmara, Teamur Aghamolaei, Abdoulhossain Madani, Zahra Hosseini, Shahram Zare
Background and aim: It has been revealed that taxi drivers break more traffic rules than ordinary drivers. Such risky behaviors include stopping at prohibited areas and sudden change of direction. The present study aimed to determine the Risky Behaviors of Taxi Drivers in Bandar Abbas, Iran. Methods: In this cross-sectional study, 184 taxi drivers were randomly selected from eight taxi stations located at different parts of Bandar Abbas city in 2016. Taxi drivers' risky behaviors were evaluated via a 20-item questionnaire...
April 2018: Electronic Physician
Shahram Rabbani, Masoud Soleimani, Mohammad Sahebjam, Mohammad Imani, Azadeh Haeri, Ali Ghiaseddin, Seyed Mahdi Nassiri, Jalil Majd Ardakani, Maryam Tajik Rostami, Arash Jalali, Seyed Hossein Ahmadi Tafti
Wharton's jelly mesenchymal stem cells (HWJMSCs) hold promise for myocardial regeneration, but optimal treatment regimen (preferably with a growth factor) is required to maximize functional benefits. The aim of this study was to explore the cardioprotective and angiogenesis effects of HWJMSCs combined with insulin-like growth factor-1 (IGF-1) in the treatment of acute myocardial infarction. The hydrogel consisted of Polyethylene glycol (PEG) and hyaluronic acid was prepared and characterized with regards to rheology, morphology, swelling, degradation, and release behaviors...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Shahram Torabian, Salar Farhangi-Abriz, Judith Rathjen
This research was conducted to evaluate effects of biochar (50 and 100 g kg-1 soil) and lignite (50 and 100 g kg-1 soil) treatments on H+ -ATPase and H+ -PPase activity of root tonoplast, nutrient content, and performance of mung bean under salt stress. High saline conditions increased H+ -ATPase and H+ -PPase activities in root tonoplast, sodium (Na) content, reactive oxygen species (H2 O2 and O2 - ) generation, relative electrolyte leakage (REL) and 2,2-Diphenyl-1-picrylhydrazyl (DPPH) activity in root and leaf, but decreased relative water content (RWC), chlorophyll content index, leaf area, potassium (K), calcium (Ca), magnesium (Mg), zinc (Zn) and iron (Fe) content of plant tissues, root and shoot dry weight of mung bean...
May 31, 2018: Plant Physiology and Biochemistry: PPB
Julia Heller, Shahram Mirzazade, Sandro Romanzetti, Ute Habel, Birgit Derntl, Nils M Freitag, Jörg B Schulz, Imis Dogan, Kathrin Reetz
•Understanding of the phenotypic heterogeneity of Parkinson's disease is needed.•Gender and genetics determine manifestation and progression of Parkinson's disease.•Altered emotion processing in Parkinson's disease is specific to male patients.•This is influenced by endocrinal and genetic factors in both genders.•This finding may impact the diagnosis and treatment of emerging clinical features.
2018: NeuroImage: Clinical
Pritesh Desai, Vikas Tahiliani, Georges Abboud, Jessica Stanfield, Shahram Salek-Ardakani
Respiratory infection with vaccinia virus (VacV) elicits robust CD8+ T cell responses that play an important role in host resistance. In the lung, VacV encounters multiple tissue resident APC populations, but which cell plays a dominant role in priming of virus-specific CD8+ effector T cell responses remains poorly defined. We used Batf3-/- mice to investigate the impact of CD103+ DC and CD8α+ DC deficiency on anti-VacV CD8+ T cell responses. We found that Batf3-/- mice were more susceptible to VacV infection, exhibiting profound weight loss, which correlated with impaired accumulation of IFN-γ-producing CD8+ T cell in the lungs...
June 6, 2018: Journal of Virology
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