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Hormone contraception

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https://www.readbyqxmd.com/read/28427990/neuropeptide-y-not-involved-in-cutaneous-vascular-control-in-young-human-females-taking-oral-contraceptive-hormones
#1
Gary J Hodges, Zachary T Martin, Andrew T Del Pozzi
We previously reported that the cutaneous vasodilator response to local warming in males required noradrenaline (NA) and neuropeptide-Y (NPY). Animal work has shown no role for NPY in female vascular control. We investigated the contribution of NA and NPY in human female cutaneous vascular control. Nine female and nine male participants volunteered. To elucidate whether synthetic oestrogen and progesterone altered cutaneous vascular responses, females were tested in high-hormone (HH) and low-hormone (LH) phases of oral contraceptive pill (OCP)...
April 18, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28426980/hormonal-and-reproductive-risk-factors-of-papillary-thyroid-cancer-a-population-based-case-control-study-in-france
#2
Emilie Cordina-Duverger, Christophe Leux, Monica Neri, Catherine Tcheandjieu, Anne-Valérie Guizard, Claire Schvartz, Thérèse Truong, Pascal Guénel
The three times higher incidence of thyroid cancer in women compared to men points to a role of female sex hormones in its etiology. However the effects of these factors are poorly understood. We analyzed the association between thyroid cancer and hormonal and reproductive factors among women enrolled in CATHY, a population-based case-control study conducted in France. The study included 430 cases of papillary thyroid cancer and 505 controls frequency-matched on age and area of residence. The odds ratios for thyroid cancer increased with age at menarche (p trend 0...
April 17, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28426619/committee-opinion-no-698-hormone-therapy-in-primary-ovarian-insufficiency
#3
(no author information available yet)
Primary ovarian insufficiency describes a spectrum of declining ovarian function and reduced fecundity due to a premature decrease in initial follicle number, an increase in follicle destruction, or poor follicular response to gonadotropins. The sequelae of primary ovarian insufficiency include vasomotor symptoms, urogenital atrophy, osteoporosis and fracture, cardiovascular disease, and increased all-cause mortality. In women with primary ovarian insufficiency, systemic hormone therapy (HT) is an effective approach to treat the symptoms of hypoestrogenism and mitigate long-term health risks if there are no contraindications to treatment...
May 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28426614/committee-opinion-no-698-summary-hormone-therapy-in-primary-ovarian-insufficiency
#4
(no author information available yet)
Primary ovarian insufficiency describes a spectrum of declining ovarian function and reduced fecundity due to a premature decrease in initial follicle number, an increase in follicle destruction, or poor follicular response to gonadotropins. The sequelae of primary ovarian insufficiency include vasomotor symptoms, urogenital atrophy, osteoporosis and fracture, cardiovascular disease, and increased all-cause mortality. In women with primary ovarian insufficiency, systemic hormone therapy (HT) is an effective approach to treat the symptoms of hypoestrogenism and mitigate long-term health risks if there are no contraindications to treatment...
May 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28422361/risks-of-thromboembolism-associated-with-hormone-contraceptives-in-japanese-compared-with-western-women
#5
Takao Kobayashi, Kazuko Sugiura, Toshiyuki Ojima
We extracted 581 thromboembolic events associated with combined oral contraceptives (COC) that occurred between 2004 and 2013 in Japan, from the Pharmaceuticals and Medical Devices Agency database. The most common thromboembolic events associated with COC were deep vein thrombosis, pulmonary embolism and their combination. The reported thromboembolic events increased year by year, in association with an increase in the quantity of prescribed low-dose estrogen progestin after approval for health insurance coverage for dysmenorrhea in 2008 in Japan...
April 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28417005/reversibility-of-vasalgel%C3%A2-male-contraceptive-in-a-rabbit-model
#6
Donald Waller, David Bolick, Elaine Lissner, Christopher Premanandan, Gary Gamerman
BACKGROUND: Development of a non-hormonal long-acting reversible contraceptive for men could have a significant impact on reducing unintended pregnancies. Vasalgel™ is a high molecular weight polymer consisting of styrene-alt-maleic acid (SMA) dissolved in dimethyl sulfoxide being developed as a reversible male contraceptive device. It forms a hydrogel when implanted into the vasa deferentia, which prevents the passage of sperm. Previous studies in the rabbit have proven its efficacy, durability and rapid onset...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28413042/no-329-canadian-contraception-consensus-part-4-of-4-chapter-9-combined-hormonal-contraception
#7
Amanda Black, Edith Guilbert, Dustin Costescu, Sheila Dunn, William Fisher, Sari Kives, Melissa Mirosh, Wendy V Norman, Helen Pymar, Robert Reid, Geneviève Roy, Hannah Varto, Ashley Waddington, Marie-Soleil Wagner, Anne Marie Whelan
OBJECTIVE: To provide guidelines for health care providers on the use of contraceptive methods to prevent pregnancy and on the promotion of healthy sexuality. OUTCOMES: Overall efficacy of cited contraceptive methods, assessing reduction in pregnancy rate, safety, and side effects; the effect of cited contraceptive methods on sexual health and general well-being; and the availability of cited contraceptive methods in Canada. EVIDENCE: Medline and the Cochrane Database were searched for articles in English on subjects related to contraception, sexuality, and sexual health from January 1994 to December 2015 in order to update the Canadian Contraception Consensus published February-April 2004...
April 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28412867/weight-gain-body-image-and-sexual-function-in-young-patients-treated-with-contraceptive-vaginal-ring-a-prospective-pilot-study
#8
Elena Morotti, Paolo Casadio, Francesca Guasina, Bruno Battaglia, Mara Mattioli, Cesare Battaglia
INTRODUCTION: Oral contraceptives could induce mood changes. As far as our knowledge, there are no studies in literature that have examined the role of vaginal contraception in self-perceived body image. AIM: To evaluate the effects of intravaginal contraception on weight gain and perceived body image in relation with the Beck's Depression Inventory questionnaire (BDI) and the McCoy Female Sexuality Questionnaire (MFSQ). METHODS: Twenty-one adult (18-35 years old) eumenorrheic (menstrual cycle of 25-35 days), lean (body mass index - BMI - of 19-25 kg/m(2)) women who were referred for hormonal contraception were administered the Stunkard Figure Rating Scale (FRS), BDI and MFSQ...
April 17, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28410124/wildlife-population-management-are-contraceptive-vaccines-a-feasible-proposition
#9
Satish Kumar Gupta, Vidisha Minhas
To minimize human-animal conflicts for habitation and burden of zoonotic diseases, it is imperative to develop new strategies for wildlife population management. In this direction, contraceptive vaccines eliciting immune response against hormones/proteins critical for reproduction have emerged as one of the promising options. Contraceptive vaccines based on neutralization of gonadotropin releasing hormone (GnRH) have been used for inhibition of fertility in various species such as wild horses, white-tailed deer, pigs, cats, dogs etc...
June 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28409819/spermicidal-efficacy-of-vrp-a-synthetic-cationic-antimicrobial-peptide-inducing-apoptosis-and-membrane-disruption
#10
Prasanta Ghosh, Arpita Bhoumik, Sudipta Saha, Sandipan Mukherjee, Sarfuddin Azmi, Jimut Kanti Ghosh, Sandhya Rekha Dungdung
Presently available contraceptives are mostly hormonal or detergent in nature with numerous side effects like irritation, lesion, inflammation in vagina, alteration of body homeostasis etc. Antimicrobial peptides with spermicidal activity but without adverse effects may be suitable alternatives. In the present study spermicidal activity of a cationic antimicrobial peptide VRP on human spermatozoa has been elucidated. Progressive forward motility of human spermatozoa was instantly stopped after 100 µM VRP treatment and at 350 µM all kinds of sperm motility ceased within 20 seconds as assessed by the Sander-Cramer assay...
April 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28409216/oral-contraceptive-use-and-fracture-risk-a-retrospective-study-of-12-970-women-in-the-uk
#11
S Dombrowski, L Jacob, P Hadji, K Kostev
In the present retrospective case-control study, we compared 6485 women with fractures and 6485 women without fractures from 135 general practitioner offices in the UK. Women without bone fractures were statistically more likely to have been exposed to oral contraception, depending on their age and therapy duration. INTRODUCTION: The aim of this analysis was to compare the risk of bone fracture in women using hormonal contraception with that in women who have never used hormonal contraception...
April 13, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28409184/comparison-of-affect-changes-during-the-ovulatory-phase-in-women-with-and-without-hormonal-contraceptives
#12
Ana Ocampo Rebollar, Francisco J Menéndez Balaña, Montserrat Conde Pastor
Studies about affect changes during the menstrual cycle and the role of hormones in these changes have yielded contradictory results. Often research has focused on the pre-menstrual phase, with few studies paying specific attention to the affect changes around ovulation. In this research thirty women completed a daily questionnaire measuring the positive and negative affect during their menstrual cycle. These women were divided in two groups: hormonally-contracepting and naturally-cycling. The Positive and Negative Affect Schedule was used to measure the affect...
April 2017: Heliyon
https://www.readbyqxmd.com/read/28408067/polyphenol-supplementation-inhibits-physiological-increase-of-prostaglandin-e2-during-reproductive-period-a-randomized-clinical-trial
#13
A M Zilio, P Zielinsky, I Vian, K Lampert, D Raupp, C Weschenfelder, C Brum, A Arnt, A Piccoli, L H Nicoloso, M I Schaun, M Markoski
Anti-inflammatory property of polyphenols and their effect on the metabolism of prostaglandins is not established in healthy humans. This study aimed to evaluate the effect of polyphenol supplementation in plasma levels of prostaglandin E2 and other markers of inflammation and oxidative stress in women using contraceptives. In this randomized double-blind clinical trial, women aged 25-35 years were selected. Participants received capsules containing polyphenols or placebo, to be consumed for fifteen days. From 40 women randomized, 28 completed the study...
April 5, 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28401937/progesterone-based-compounds-affect-immune-responses-and-susceptibility-to-infections-at-diverse-mucosal-sites
#14
REVIEW
Olivia J Hall, Sabra L Klein
Over 100 million women worldwide are currently on progesterone-based contraceptives to improve their health outcomes through reduced maternal mortality and family planning. In addition to their role in reproduction, progesterone-based compounds modulate immune responses throughout the body, particularly at mucosal sites. By binding to receptors located in immune cells, including natural killer cells, macrophages, dendritic cells, and T cells, as well in non-immune cells, such as epithelial and endothelial cells, progesterone-based compounds alter cellular signaling and activity to affect the outcome of infections at diverse mucosal sites, including the genital, gastrointestinal, and respiratory tracts...
April 12, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28400322/bladder-involvement-in-stage-i-endometriosis
#15
Paula C Brady, Stacey A Missmer, Marc R Laufer
BACKGROUND: Endometriosis-the ectopic implantation of endometrial-like tissue-affects 10% of female adolescents and adults. Bladder involvement, causing dysuria and hematuria, occurs in a very small minority of endometriosis patients. CASE: The patient presented at age 12 years with dysuria and pelvic pain. Laparoscopy revealed Stage I endometriosis. Postoperatively, she reported persistent dysuria and passage of tissue in her urine. Cystoscopy showed diffuse erythema; urine cytology revealed glandular and spindle cells suggestive of endometriosis...
April 8, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28399558/brief-report-hormonal-contraception-is-not-associated-with-reduced-art-effectiveness-among-women-initiating-art-evidence-from-longitudinal-data
#16
Rena C Patel, Jared M Baeten, Renee Heffron, Ting Hong, Nicole L Davis, Kavita Nanda, Robert W Coombs, Jairam R Lingappa, Elizabeth A Bukusi, Stacey Hurst, Katherine K Thomas, Athena P Kourtis, Nelly Mugo
BACKGROUND: To explore the association between concomitant hormonal contraceptive and antiretroviral therapy (ART) use and (1) plasma viral suppression and (2) genital HIV shedding among HIV-positive women initiating ART. METHODS: We analyzed plasma viral load and genital viral RNA shedding from 1079 HIV-positive women initiating ART who were followed prospectively in 3 sub-Saharan African HIV prevention studies. Plasma and endocervical swab samples were collected every 6 months...
May 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28393811/a-cross-sectional-clinical-study-to-evaluate-mobility-of-teeth-during-pregnancy-using-periotest
#17
Poonam Sujeet Mishra, Pramod P Marawar, Sunil Surendraprasad Mishra
BACKGROUND AND OBJECTIVE: Over a century, an increased prevalence of gingival diseases associated with increasing plasma sex steroid hormone levels has been reported. These situations present unique challenges to the oral health-care professional. It is believed that hormonal fluctuations such as those associated with pregnancy, menstruation, and use of hormonal contraceptives lead to an increase in tooth mobility. However, this effect of female sex hormones on periodontal ligament and tooth-supporting alveolar bone has rarely been investigated...
January 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28393651/anti-m%C3%A3-llerian-hormone-does-not-predict-time-to-pregnancy-results-of-a-prospective-cohort-study
#18
M Depmann, S L Broer, M J C Eijkemans, I A J van Rooij, G J Scheffer, J Heimensem, B W Mol, F J M Broekmans
In order to study whether ovarian reserve tests (ORTs) can predict time to ongoing pregnancy, we conducted a prospective cohort study in a cohort of healthy pregnancy planners. A total of 102 pregnancy planners were followed for 1 year, or until ongoing pregnancy occurred, after cessation of contraceptives). A baseline measurement of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH) and antral follicle count (AFC) was conducted. At the end of follow-up, a semen analysis was performed and chlamydia antibody titres were assessed...
April 10, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28386985/endometriosis-an-everlasting-challenge
#19
Mette Haase Moen
Endometriosis is one of the most common benign gynecological diseases affecting 5-10% of women of fertile age, and the condition has received much attention. In spite of this, there are still challenges concerning diagnosing and treatment. The diagnostic delay can be more than ten years, and is especially long concerning teenagers. The symptoms can start already in adolescence, but this knowledge has not fully reached out to the medical profession, for example to general practitioners and pediatricians. As no hormonal treatment has proved to be superior, the least complicated drugs such as combined oral contraceptives or progestins should be the first choice for control of pain...
April 7, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28383429/is-the-oral-contraceptive-or-hormone-replacement-therapy-a-risk-factor-for-cholelithiasis-a-systematic-review-and-meta-analysis
#20
Siqi Wang, Yuqiong Wang, Jinming Xu, Yuxin Chen
BACKGROUND: Association between exogenous estrogen intake and cholelithiasis risk has been reported in several epidemiological studies, including oral contraceptive (OC) and hormone replacement therapy (HRT), while the results were controversial. This study aimed to perform a comprehensive meta-analysis of this issue. METHODS: PUBMED, EMBASE, and Cochrane library database were searched up to October 2016. Two reviewers independently extracted data from eligible studies, relative risks (RRs), and/or odds ratios (ORs) with 95% confidence intervals (95% CIs) for the highest versus lowest categories of intake were adopted...
April 2017: Medicine (Baltimore)
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