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https://www.readbyqxmd.com/read/28087972/lack-of-effect-of-oral-cabotegravir-on-the-pharmacokinetics-of-a-levonorgestrel-ethinyl-estradiol-containing-oral-contraceptive-in-healthy-adult-females
#1
C Trezza, S L Ford, E Gould, Y Lou, C Huang, J M Ritter, A M Buchanan, W Spreen, P Patel
AIM(S): This study aimed to investigate whether cabotegravir (CAB), an integrase inhibitor in development for treatment and prevention of HIV-1, influences the pharmacokinetics (PK) of a levonorgestrel (LNG) and ethinyl estradiol (EE)-containing oral contraceptive (OC) in healthy women. METHODS: In this open-label, fixed-sequence crossover study, healthy female subjects received LNG 0.15 mg/EE 0.03 mg tablet once daily Days 1-10 alone and with oral CAB 30 mg once daily Days 11-21...
January 14, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28087052/contraceptive-practices-of-women-with-complex-congenital-heart-disease
#2
Pamela D Miner, Mary M Canobbio, Dorothy D Pearson, Mary Schlater, Yvonne Balon, Kathryn J Junge, Ami Bhatt, Deena Barber, Michelle J Nickolaus, Adrienne H Kovacs, Philip Moons, Kate Shaw, Susan M Fernandes
Understanding the contraceptive practices of women with complex congenital heart disease (CHD) and providing them individualized contraception counseling may prevent adverse events and unplanned high-risk pregnancies. Given this, we sought to examine the contraceptive practices in women with CHD, describe adverse events associated with contraceptive use, and describe the provision of contraception counseling. Women >18 years were recruited from 2011 to 2014 from 9 adult CHD (ACHD) centers throughout North America...
December 18, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28076614/association-between-asthma-and-female-sex-hormones
#3
Raquel Prudente de Carvalho Baldaçara, Ivaldo Silva
CONTEXT AND OBJECTIVE: The relationship between sex hormones and asthma has been evaluated in several studies. The aim of this review article was to investigate the association between asthma and female sex hormones, under different conditions (premenstrual asthma, use of oral contraceptives, menopause, hormone replacement therapy and pregnancy). DESIGN AND SETTING: Narrative review of the medical literature, Universidade Federal do Tocantins (UFT) and Universidade Federal de São Paulo (Unifesp)...
January 5, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28076534/absorption-and-metabolization-of-sex-hormones-and-their-transformation-into-contraceptive-technologies-the-paths-taken-by-medical-thought-in-brazil
#4
Claudia Bonan, Luiz Antonio Teixeira, Andreza Rodrigues Nakano
The article analyses knowledge assimilation and the development of clinical and research practices relating to sex hormones among Brazilian gynaecologists. It discusses the paths taken by medical thought from the reception of the hormones to their transformation into contraceptives. Our objective is to comprehend styles of introducing and disseminating medical technologies in the area of reproductive health in Brazil. It uses methods of historical analysis and takes as its source the Anais Brasileiros de Ginecologia, a journal published between 1936 and 1970...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28076528/the-brief-life-of-norplant%C3%A2-in-brazil-controversies-and-reassemblages-between-science-society-and-state
#5
Ana Cristina de Lima Pimentel, Cláudia Bonan Jannotti, Paula Gaudenzi, Luiz Antonio da Silva Teixeira
Norplant® is the brand name of the world's first registered subdermal hormonal contraceptive implant, developed by the laboratories of the Population Council, an international organisation working in the area of fertility and population growth. The article revisits the trajectory of this contraceptive in Brazil from its arrival through clinical trials to its eventual ban in 1986 by the Brazilian regulatory agency responsible for approving medications at the time. Its circulation generated controversies related to research practices, side effects and political uses of the drug as a birth control method...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28070003/pregnancy-hormonal-treatments-for-infertility-contraception-and-menopause-in-women-after-ischemic-stroke-a-consensus-document
#6
Valeria Caso, Alberto Falorni, Cheryl D Bushnell, Monica Acciarresi, José Remohí, Nikola Sprigg, Sandro Gerli
No abstract text is available yet for this article.
January 9, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28066104/impact-of-oral-contraceptive-pills-on-central-corneal-thickness-in-young-women
#7
Bengi Ece Kurtul, Besime Inal, Pinar Altiaylik Ozer, Emrah Utku Kabatas
OBJECTIVES: Hormonal changes during oral contraceptive pill (OCP) use may affect central corneal thickness (CCT) values. We aimed to evaluate the impact of OCP use on CCT values in healthy young women. MATERIALS AND METHODS: Fifty women subjects who use OCP for contraception (Group 1) and forty control subjects (Group 2) who do not use OCP were included in this prospective study. None of the patients had any history of systemic or ocular diseases. The CCT values measured by ultrasonic pachymeter (Nidek US-4000 Echoscan, Japan) and the intraocular pressure (IOP) values were measured by noncontact tonometer (Reichert 7 CR Corneal Response Technology, USA) at the time of admission to our clinic...
November 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28065695/perfusion-of-the-uterine-junctional-zone-in-nulliparous-and-primiparous-women-assessed-by-dce-mri-as-a-function-of-menstrual-cycle-and-hormonal-contraception
#8
L J Meylaerts, L Wijnen, M Bazot, M Grieten, W Ombelet, M Vandersteen
PURPOSE: To evaluate the perfusion parameters of inner and outer myometrium in healthy nulliparous and primiparous women who are and who are not currently using hormonal contraceptives by means of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). MATERIAL AND METHODS: We performed pelvic 1.5T DCE-MRI on 98 women: 18 nulliparous non-users, 30 nulliparous users, 12 primiparous non-users and 38 primiparous users of hormonal contraception (mean age respectively 26...
January 6, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28063910/racial-ethnic-differences-in-contraceptive-preferences-beliefs-and-self-efficacy-among-women-veterans
#9
Lisa S Callegari, Xinhua Zhao, Eleanor Bimla Schwarz, Elian Rosenfeld, Maria K Mor, Sonya Borrero
BACKGROUND: Significant racial/ethnic disparities in unintended pregnancy persist in the US, with the highest rates observed among low-income black and Hispanic women. Differences in contraceptive preferences, beliefs, and self-efficacy may be instrumental in understanding contraceptive behaviors that underlie higher rates of unintended pregnancy among racial/ethnic minorities. OBJECTIVES: Our objective was to understand how contraceptive preferences, beliefs and self-efficacy vary by race and ethnicity among women veterans...
January 4, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28063830/implications-of-dispensing-self-administered-hormonal-contraceptives-in-a-one-year-supply-a-california-case-study
#10
Sara B McMenamin, Shana Alex Charles, Nadia Tabatabaeepour, Erin Shigekawa, Garen Corbett
On September 23, 2016, California became the 6th state to pass legislation requiring health plans and insurers to cover a 12-month supply of FDA-approved self-administered hormonal contraceptives such as contraceptive pills, patches, and vaginal rings. This legislation is estimated to result in 47% of current contraceptive pill, patch, and ring users receiving a 12-month supply dispensed at one time. This shift in dispensing patterns was estimated to result in a reduction of 15,000 unintended pregnancies; 2000 fewer miscarriages; and 7000 fewer abortions in California decreasing total net health care expenditures by 0...
January 4, 2017: Contraception
https://www.readbyqxmd.com/read/28060009/drug-interactions-between-hormonal-contraceptives-and-antiretrovirals-a-systematic-review
#11
Kavita Nanda, Gretchen S Stuart, Jennifer Robinson, Andrew L Gray, Naomi K Tepper, Mary E Gaffield
OBJECTIVE: To summarize published evidence on drug interactions between hormonal contraceptives and antiretrovirals. DESIGN: Systematic review of the published literature. METHODS: We searched PUBMED, POPLINE, and EMBASE for peer-reviewed publications of studies (in any language) from inception through September 21, 2015. We included studies of women using hormonal contraceptives and antiretrovirals concurrently. Outcomes of interest were effectiveness of either therapy, toxicity, and pharmacokinetics...
January 4, 2017: AIDS
https://www.readbyqxmd.com/read/28054964/effect-of-two-different-multimicronutrient-supplements-on-vitamin-d-status-in-women-of-childbearing-age-a-randomized-trial
#12
Stefan Pilz, Andreas Hahn, Christiane Schön, Manfred Wilhelm, Rima Obeid
The German Nutrition Society raised in 2012 the recommended daily vitamin D intake from 200 to 800 international units (IU) to achieve 25-hydroxyvitamin D (25(OH)D) levels of at least 50 nmol/L, even when endogenous vitamin D synthesis is minimal such as in winter. We aimed to evaluate this recommendation in women of childbearing age. This is a single-center, randomized, open trial conducted from 8 January to 9 May 2016 in Esslingen, Germany. We randomized 201 apparently healthy women to receive for 8 weeks a daily multimicronutrient supplement containing either 200 IU (n = 100) or 800 IU vitamin D3 (n = 101)...
January 4, 2017: Nutrients
https://www.readbyqxmd.com/read/28051087/effects-of-depot-medroxyprogesterone-acetate-on-the-immune-microenvironment-of-the-human-cervix-and-endometrium-implications-for-hiv-susceptibility
#13
K K Smith-McCune, J F Hilton, U Shanmugasundaram, J W Critchfield, R M Greenblatt, D Seidman, S Averbach, L C Giudice, B L Shacklett
Depot-medroxyprogesterone acetate is a commonly used injectable contraceptive that has been associated with an increased risk of HIV acquisition. This study compares effects of depot-medroxyprogesterone acetate on immune parameters from several upper reproductive tract compartments relevant to HIV-1 susceptibility in repetitive samples from 15 depot-medroxyprogesterone acetate users and 27 women not on hormonal contraceptives. Compared with samples from unexposed women in the mid-luteal phase, depot-medroxyprogesterone acetate use was associated with: increased endocervical concentrations of MCP1 and IFNalpha2; decreased endocervical concentrations of IL1beta and IL6; increased proportions of endometrial CD4+ and CD8+ cells expressing the activation marker HLADR; increased density of endometrial macrophages; and decreased density of endometrial regulatory T cells...
January 4, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28050520/oral-health-and-oral-contraceptive-is-it-a-shadow-behind-broad-day-light-a-systematic-review
#14
REVIEW
Irfan Ali, Basavaraj Patthi, Ashish Singla, Ritu Gupta, Kuldeep Dhama, Lav Kumar Niraj, Jishnu Krishna Kumar, Monika Prasad
INTRODUCTION: Oral contraceptives are one of the risk factors for gingival disease. Oral contraceptives can affect the proliferation of cell, growth and differentiation of tissues in the periodontium. Nowadays recent research has suggested that the newer generation oral contraceptives have less influence on gingival diseases. AIM: The purpose of this study was to systematically review the effect of oral contraceptives on periodontium. MATERIALS AND METHODS: A literature review was performed; PubMed, PubMed Central and Cochrane Library, Embase, Google Scholar were searched from 1970 up to December 2015 to identify appropriate studies...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28041992/changes-in-body-composition-in-women-using-long-acting-reversible-contraception
#15
Priscilla de Nazaré Silvados Santos, Tessa Madden, Karen Omvig, Jeffrey F Peipert
OBJECTIVE: Users of hormonal long-acting reversible contraception (LARC) report weight gain as a side effect, but few studies have assessed body composition change among LARC users. We evaluated weight and body composition of healthy women using the levonorgestrel intrauterine system (LNG-IUS), copper intrauterine device (copper IUD), or etonogestrel implant (ENG implant). We hypothesized that weight gain and body composition over 12 months would not differ between copper IUD, LNG-IUS, and ENG implant users...
December 29, 2016: Contraception
https://www.readbyqxmd.com/read/28038949/could-misreporting-of-condom-use-explain-the-observed-association-between-injectable-hormonal-contraceptives-and-hiv-acquisition-risk
#16
Jennifer A Smith, Renee Heffron, Ailsa R Butler, Connie Celum, Jared M Baeten, Timothy B Hallett
OBJECTIVE: Some observational studies have suggested an association between the use of hormonal contraceptives (HC) and HIV acquisition. One major concern is that differential misreporting of sexual behaviour between HC users and non-users may generate artificially inflated risk estimates. STUDY DESIGN: We developed an individual-based model that simulates the South African HIV serodiscordant couples analysed for HC-HIV risk by Heffron et al. (2012). We varied the pattern of misreporting condom use between HC users and non-users and reproduced the trial data under the assumption that HC use is not associated with HIV risk...
December 27, 2016: Contraception
https://www.readbyqxmd.com/read/28034652/use-of-combined-hormonal-contraceptives-among-women-with-migraines-and-risk-of-ischemic-stroke
#17
Steven W Champaloux, Naomi K Tepper, Michael Monsour, Kathryn M Curtis, Maura K Whiteman, Polly A Marchbanks, Denise J Jamieson
BACKGROUND: Migraine with aura and combined hormonal contraceptives are independently associated with an increased risk of ischemic stroke. However, little is known about whether there are any joint effects of migraine and hormonal contraceptives on risk of stroke. OBJECTIVE: To estimate the incidence of stroke in women of reproductive age and examine the association between combined hormonal contraceptive use, migraine type (with or without aura), and ischemic stroke...
December 26, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28026087/oral-contraceptive-therapy-reduces-serum-relaxin-2-in-elite-female-athletes
#18
Sayaka Nose-Ogura, Osamu Yoshino, Kaori Yamada-Nomoto, Mariko Nakamura, Miyuki Harada, Michiko Dohi, Toru Okuwaki, Yutaka Osuga, Takashi Kawahara, Shigeru Saito
AIM: Recent investigations have demonstrated that athletes with high relaxin-2 levels have a high risk of anterior cruciate ligament injuries, while athletes taking oral contraceptives (OC) have low relaxin-2 levels. It has not yet been clarified whether taking OC reduces relaxin-2 levels. The purpose of this study was to investigate changes in relaxin-2 levels in athletes taking OC. METHODS: Levels of relaxin-2, estradiol, progesterone, luteinizing hormone and follicle-stimulating hormone were measured in serum samples (n = 183) from 106 elite female athletes...
December 27, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28025764/a-prospective-study-of-reproductive-factors-and-exogenous-hormone-use-in-relation-to-ovarian-cancer-risk-among-black-women
#19
Traci N Bethea, Julie R Palmer, Lucile L Adams-Campbell, Lynn Rosenberg
PURPOSE: Extensive data in White women have linked oral contraceptive use, tubal ligation, and parity to reduced risk of ovarian cancer; results on postmenopausal female hormone use are mixed. Few studies, all of which are case-control studies, have been undertaken among Black women. The aim of the present study was to prospectively assess associations of reproductive factors and exogenous hormones with ovarian cancer among Black women. METHODS: During follow-up from 1995 to 2013 in the Black Women's Health Study, a prospective cohort study, 115 incident cases of ovarian cancer were identified...
December 27, 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28025018/pharmacy-provision-of-sexual-and-reproductive-health-commodities-to-young-people-a-systematic-literature-review-and-synthesis-of-the-evidence
#20
REVIEW
Lianne Gonsalves, Michelle J Hindin
BACKGROUND: We conducted a systematic review of peer-reviewed literature on youth access to, use of and quality of care of sexual and reproductive health (SRH) commodities through pharmacies. METHODS: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol, we searched for publications from 2000 to 2016. To be eligible for inclusion, articles had to address the experiences of young people (aged 25 years and below) accessing SRH commodities (e...
December 23, 2016: Contraception
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