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https://www.readbyqxmd.com/read/28807160/treatment-of-chinese-herbal-medicine-for-female-infertility
#1
Dan Jiang, Lily Li, Bai-Yun Zeng
Female infertility is when a woman of reproductive age and sexual active, without contraception, cannot get pregnant after a year and more or keeps having miscarriages. Although conventional treatments for infertility such as hormone therapy, in vitro fertilization and many more, helped many female patients with infertility get pregnant during past a few decades, it is far from satisfactory with prolonging treatment time frames and emotional and financial burden. In recent years, more patients with infertile problems are seeking to alternative and complementary medicines to achieve a better outcome...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28806162/combined-hormonal-contraceptives-and-migraine-an-update-on-the-evidence
#2
REVIEW
Anne H Calhoun, Pelin Batur
Combined hormonal contraceptives are contraindicated in women who have migraine with aura, in whom these drugs can increase the risk of ischemic stroke. However, this contraindication is based on data from the 1960s and 1970s, when oral contraceptives contained much higher doses of estrogen. Stroke risk is not significantly increased with today's preparations, many of which contain less than 30 μg of ethinyl estradiol. Further, in continuous regimens, ultra-low-dose formulations--those that contain less than 20 μg of ethinyl estradiol--may help prevent menstrual migraine and reduce the frequency of aura...
August 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28801053/cervical-mucus-and-contraception-what-we-know-and-what-we-don-t
#3
REVIEW
Leo Han, Rebecca Taub, Jeffrey T Jensen
The properties of cervical mucus vary in response to both natural and artificial hormonal changes. During ovulatory cycles, cervical mucus becomes increasingly fluid and favorable to sperm penetration as estradiol levels increase. Following ovulation, as estradiol levels decrease and progesterone increases, the mucus increases in viscosity and becomes impenetrable to sperm. Cervical mucus thickening also occurs in response to synthetic progestins administered by various routes, and this is commonly believed to represent the essential contraceptive mechanism of progestin-only methods that do not block ovulation...
August 8, 2017: Contraception
https://www.readbyqxmd.com/read/28797287/is-a-high-serum-copper-concentration-a-risk-factor-for-implantation-failure
#4
Hidehiko Matsubayashi, Kotaro Kitaya, Kohei Yamaguchi, Rie Nishiyama, Yukiko Takaya, Tomomoto Ishikawa
BACKGROUND: Copper-containing contraceptive devices may deposit copper ions in the endometrium, resulting in implantation failure. The deposition of copper ions in many organs has been reported in patients with untreated Wilson's disease. Since these patients sometimes exhibit subfertility and/or early pregnancy loss, copper ions were also considered to accumulate in the uterine endometrium. Wilson's disease patients treated with zinc successfully delivered babies because zinc interfered with the absorption of copper from the gastrointestinal tract...
August 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28796678/socioeconomic-status-as-a-risk-factor-for-unintended-pregnancy-in-the-contraceptive-choice-project
#5
Abigail Iseyemi, Qiuhong Zhao, Colleen McNicholas, Jeffrey F Peipert
OBJECTIVE: To evaluate the association of low socioeconomic status as an independent risk factor for unintended pregnancy. METHODS: We performed a secondary analysis of data from the Contraceptive CHOICE project. Between 2007 and 2011, 9,256 participants were recruited and followed for up to 3 years. The primary outcome of interest was unintended pregnancy; the primary exposure variable was low socioeconomic status, defined as self-report of either receiving public assistance or having difficulty paying for basic necessities...
August 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28795075/the-effect-of-menstrual-cycle-and-contraceptives-on-acl-injuries-and-laxity-a-systematic-review-and-meta-analysis
#6
REVIEW
Simone D Herzberg, Makalapua L Motu'apuaka, William Lambert, Rongwei Fu, Jacqueline Brady, Jeanne-Marie Guise
BACKGROUND: Women are at substantially greater risk for anterior cruciate ligament (ACL) injuries than are men. PURPOSE: To conduct a systematic review and meta-analysis of the literature to clarify the effect of the menstrual cycle and contraceptives on the laxity of and noncontact injuries to the ACL. STUDY DESIGN: Systematic review; Level of evidence, 4. METHODS: Searches were conducted using MEDLINE (1946-August 2016), the Cochrane Library Database, clinical trial registries, and related reference lists...
July 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28780893/abnormal-uterine-bleeding-in-perimenopause
#7
S R Goldstein, M A Lumsden
Abnormal uterine bleeding is one of the commonest presenting complaints encountered in a gynecologist's office or primary-care setting. The wider availability of diagnostic tools has allowed prompt diagnosis and treatment of an increasing number of menstrual disorders in an office setting. This White Paper reviews the advantages and disadvantages of transvaginal ultrasound, blind endometrial sampling and diagnostic hysteroscopy. Once a proper diagnosis has been established, appropriate therapy may be embarked upon...
August 7, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28780215/knowledge-of-and-interest-in-the-copper-intrauterine-device-among-women-seeking-emergency-contraception
#8
Christine Edwards, Dilzayn Panjwani, Ciara Pendrith, Anna Ly, Sheila Dunn
OBJECTIVE: Emergency contraception (EC) includes hormonal pills (levonorgestrel or ulipristal acetate) and the copper IUD (Cu-IUD). The Cu-IUD is more effective for EC than hormonal pills but remains underused, possibly because of lack of knowledge or interest. The objective of this study was to examine knowledge of and interest in the Cu-IUD for EC among Canadian women seeking EC. METHODS: The study used a cross-sectional convenience survey of English-speaking women presenting for EC at two sexual health clinics in Toronto...
August 2, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28766085/influence-of-sex-menstrual-cycle-and-oral-contraceptives-on-the-cerebrovascular-response-to-paced-deep-breathing
#9
Misha Nili, Syed Abidi, Stephania Serna, Simon Kim, Heather Edgell
PURPOSE: Deep breathing assesses autonomic function; however, many researchers/clinicians do not account for hyperventilation, brain blood flow or blood pressure. METHODS: Men and women (with/without oral contraceptives) participated. women participated during low and high hormone phases of the menstrual cycle. Blood pressure, end-tidal carbon dioxide, middle cerebral artery velocity and cerebrovascular resistance were assessed. RESULTS: Deep breathing decreased end-tidal carbon dioxide and middle cerebral artery velocity while increasing cerebrovascular resistance in all participants; blood pressure decreased in men...
August 1, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28752894/headache-in-idiopathic-intracranial-hypertension-findings-from-the-idiopathic-intracranial-hypertension-treatment-trial
#10
Deborah I Friedman, Peter A Quiros, Prem S Subramanian, Luis J Mejico, Shan Gao, Michael McDermott, Michael Wall
OBJECTIVE: To characterize the phenotype, headache-related disability, medical co-morbidities, use of symptomatic headache medications, and headache response to study interventions in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT). METHODS: Patients with untreated IIH and mild vision loss enrolled in the IIHTT and randomized to acetazolamide (ACZ) and weight loss or placebo (PLB) and weight loss had prospective assessment of headache disability using the Headache Impact Test-6 (HIT-6) questionnaire...
July 28, 2017: Headache
https://www.readbyqxmd.com/read/28752096/breast-density-and-breast-cancer-incidence-in-the-lebanese-population-results-from-a-retrospective-multicenter-study
#11
Christine Salem, David Atallah, Joelle Safi, Georges Chahine, Antoine Haddad, Nadine El Kassis, Laura-Maria Maalouly, Malak Moubarak, Mary Dib, Michel Ghossain
PURPOSE: To study the distribution of breast mammogram density in Lebanese women and correlate it with breast cancer (BC) incidence. METHODS: Data from 1,049 women who had screening or diagnostic mammography were retrospectively reviewed. Age, menopausal status, contraceptives or hormonal replacement therapy (HRT), parity, breastfeeding, history of BC, breast mammogram density, and final BI-RADS assessment were collected. Breast density was analyzed in each age category and compared according to factors that could influence breast density and BC incidence...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28751811/the-association-between-serum-ferritin-and-25-hydroxyvitamin-d-and-metabolic-syndrome-in-korean-women-the-korea-national-health-and-nutrition-examination-survey-2010-2012
#12
Hyun Yoon, Nan Young Bae, Mi Young Gi, Bu Yeon Park, Jeong Min Seong
The present study was conducted to assess the association between serum ferritin and 25-hydroxyvitamin D [25(OH)D] and metabolic syndrome (MetS) in Korean women. The data of a total of 9,256 adults (6,960 women without MetS and 2,296 women with MetS) aged ≥20 years from the Fifth Korean National Health and Nutrition Examination Survey (KNHANES V) (2010-2012) were analyzed. A covariance test adjusted for covariates was performed for serum ferritin levels in relation to vitamin D (vitamin D deficiency, 25(OH)D <10...
July 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/28748662/repeated-administration-of-high-dose-depot-medroxyprogesterone-acetate-does-not-alter-shivsf162p3-viral-kinetics-and-tenofovir-pharmacokinetics-when-delivered-via-intravaginal-rings
#13
Priya Srinivasan, Jining Zhang, Chuong T Dinh, Ryan S Teller, Janet M McNicholl, Patrick F Kiser, Betsy C Herold, James M Smith
BACKGROUND: Intravaginal rings (IVR) for HIV prevention will likely be used by women on depot medroxyprogesterone acetate (DMPA) hormonal contraception. We used pigtailed macaques to evaluate the effects of DMPA on tenofovir disoproxil fumarate (TDF) IVR pharmacokinetics and viral shedding. METHODS: Mucosal tenofovir (TFV) levels were compared in SHIVSF162p3 -negative DMPA-treated (n=4) and normally cycling (n=6) macaques receiving TDF IVRs. Plasma viremia and vaginal shedding were determined in groups of SHIVSF162p3 -positive DMPA-treated (n=6) and normally cycling (n=5) macaques...
August 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28743530/different-inhibitory-potential-of-sex-hormones-on-nnk-detoxification-in%C3%A2-vitro-a-possible-explanation-for-gender-specific-lung-cancer-risk
#14
Claudia Stapelfeld, Karolina-Theresa Neumann, Edmund Maser
Smoking women are probably at a higher risk to develop lung cancer than men. Different explanations exist for these findings, a gender-specific impairment of tobacco carcinogen metabolism being one of them. In this study, we examined the inhibition of NNK reduction to NNAL, the first and most important detoxication step of this tobacco-specific carcinogen. It is mediated by different carbonyl reductases of the SDR (CBR1 and 11βHSD1) and AKR (AKR1B10, AKR1C1, AKR1C2 and AKR1C4) superfamilies. Inhibition constants of NNK reduction were determined with male (testosterone) and female (estradiol, progesterone) sex hormones and the contraceptives ethinylestradiol and drospirenone in A549 cells and with purified enzymes...
July 22, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28741624/hormonal-cycle-and-contraceptive-effects-on-amygdala-and-salience-resting-state-networks-in-women-with-previous-affective-side-effects-on-the-pill
#15
Jonas Engman, Inger Sundström Poromaa, Lena Moby, Johan Wikström, Mats Fredrikson, Malin Gingnell
The mechanisms linking ovarian hormones to negative affect are poorly characterized, but important clues may come from the examination of the brain's intrinsic organization. Here, we studied the effects of both the menstrual cycle and oral contraceptives (OCs) on amygdala and salience network resting-state functional connectivity using a double-blind, randomized, and placebo-controlled design. Hormone levels, depressive symptoms, and resting-state functional connectivity were measured in 35 healthy women (24...
June 25, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28731204/urban-rural-differences-in-tubal-ligation-incidence-in-the-state-of-georgia-usa
#16
Curtis D Travers, Jessica B Spencer, Carrie A Cwiak, Ann C Mertens, Penelope P Howards
PURPOSE: To evaluate the difference in tubal ligation use between rural and urban counties in the state of Georgia, USA. METHODS: The study population included 2,160 women aged 22-45. All participants completed a detailed interview on their reproductive histories. County of residence was categorized using the National Center for Health Statistics Urban-Rural Classification Scheme. We estimated the association between urbanization of county of residence and tubal ligation using Cox regression...
July 21, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/28728451/esc-expert-statement-on-the-effects-on-mood-of-the-natural-cycle-and-progestin-only-contraceptives
#17
G S Merki-Feld, D Apter, G Bartfai, G Grandi, K Haldre, M Lech, R Lertxundi, I Lete, P Lobo Abascal, S Raine, F Roumen, D Serfaty, L P Shulman, S Skouby, J Bitzer
Hormonal fluctuations during the natural cycle, as well as progestins used for hormonal contraception, can exert effects on mood especially in vulnerable women. Negative effects of levonorgestrel-releasing intrauterine contraception on mood are rare.
July 21, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28715852/treatment-of-premenstrual-dysphoria-with-continuous-versus-intermittent-dosing-of-oral-contraceptives-results-of-a-three-arm-randomized-controlled-trial
#18
Tory A Eisenlohr-Moul, Susan S Girdler, Jacqueline L Johnson, Peter J Schmidt, David R Rubinow
BACKGROUND: Although traditionally dosed combined oral contraceptives (COCs) (21 days of active pills, 7 days of inactive pills) have not been demonstrated as superior to placebo for the treatment of premenstrual dysphoria (PMD), some randomized controlled trials (RCTs) indicate that oral contraceptives administered with a shortened or eliminated hormone-free interval are superior to placebo. However, results of such trials are mixed, and no existing studies have directly compared continuous and intermittent dosing schedules of the same oral contraceptive...
July 17, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28715060/the-complex-interaction-between-polycystic-ovary-syndrome-and-hereditary-angioedema-case-reports-and-review-of-the-literature
#19
Marina Iahn-Aun, Marcelo Vivolo Aun, Antonio Abílio Motta, Jorge Kalil, Pedro Giavina-Bianchi, Sylvia Asaka Hayashida, Edmund Chada Baracat, Gustavo Arantes Maciel
Importance: Hereditary angioedema (HAE) is a rare but severe disease, with high risk of death, and attacks have been associated to high estrogen levels. Polycystic ovary syndrome (PCOS) is a common hyperandrogenic condition, which is frequently treated with combined oral contraceptives. Objective: The aim of this study was to describe 2 clinical cases of young women diagnosed as having PCOS who developed HAE attacks after the introduction of combined estrogen-progestin pills to treat PCOS symptoms...
July 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28711501/comparing-the-androgenic-and-estrogenic-properties-of-progestins-used-in-contraception-and-hormone-therapy
#20
Renate Louw-du Toit, Meghan S Perkins, Janet P Hapgood, Donita Africander
Progestins used in endocrine therapies bind to multiple steroid receptors and are associated with several side-effects. It is thus important to understand the relationship between steroid receptor cross-reactivity and the side-effect profile of progestins. In cell lines that express negligible levels of steroid receptors, we report for the first time the binding affinities, potencies and efficacies of selected progestins from different generations determined in parallel. We show that the progestins bind to the androgen receptor (AR) with similar affinities to each other and progesterone, while none bind estrogen receptor (ER)-β, and only norethisterone acetate, levonorgestrel and gestodene bind ERα...
September 9, 2017: Biochemical and Biophysical Research Communications
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