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https://www.readbyqxmd.com/read/27910132/a-simple-method-for-preparation-of-pure-68-ga-acetate-precursor-for-formulation-of-radiopharmaceuticals-physicochemical-characteristics-of-the-68-ga-eluate-of-the-sno2-based-68-ge-68-ga-column-generator
#1
Sankha Chattopadhyay, Md Neyar Alam, Madhu Smita, Umesh Kumar, Sujata Saha Das, Luna Barua
Gallium-68 radioisotope is an excellent source in clinical positron emission tomography application due to its ease of availability from germanium-68 ((68) Ge)/gallium-68 ((68) Ga) generator having a shelf life of 1 year. In this paper, a modified method for purification of the primary eluate of (68) Ge-(68) Ga generator by using a small cation exchange resin (Dowex-50) column has been described. The breakthrough of (68) Ge before and after purification of (68) Ga eluate was 0.014% and 0.00027%, respectively...
December 1, 2016: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27905908/the-balance-between-the-serum-levels-of-il-6-and-il-10-cytokines-discriminates-mild-and-severe-acute-pneumonia
#2
Rita de Cássia Coelho Moraes de Brito, Norma Lucena-Silva, Leuridan Cavalcante Torres, Carlos Feitosa Luna, Jaílson de Barros Correia, Giselia Alves Pontes da Silva
BACKGROUND: To identify markers for earlier diagnosis of severe pneumonia, we assess the correlation between serum cytokine profile of children with different pneumonia severity. METHODS: In 25 hospitalized children, 7 with mild pneumonia and 18 with severe pneumonia, the serum concentration of 11 cytokines in three sampling times were dosed. Statistical analysis included parametric and non-parametric tests, Pearson correlation and ROC curve for cut-off definition of cytokines...
December 1, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27905680/the-burden-of-childhood-cancer-in-mexico-implications-for-low-and-middle-income-countries
#3
REVIEW
Roberto Rivera-Luna, Marta Zapata-Tarres, Jaime Shalkow-Klincovstein, Liliana Velasco-Hidalgo, Alberto Olaya-Vargas, Nicole Finkelstein-Mizrahi, Rocío Cárdenas-Cardós, Marco R Aguilar-Ortiz
In Mexico, childhood cancer incidence and mortality have increased in the last decade. Through government actions since 2005, the Popular Medical Insurance (PMI) program for childhood cancer was created. The objective of PMI was to offer early cancer diagnosis, standardized treatment regimens, and numerous pediatric oncology residency programs. It has also accredited 55 national hospitals for the care of these children. Current problems still present under the PMI include shortage of pediatric oncologists and nurses and high rate of abandonment of treatment...
December 1, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27905482/pharmacologic-modulation-of-ror%C3%AE-t-translates-to-efficacy-in-preclinical-and-translational-models-of-psoriasis-and-inflammatory-arthritis
#4
Xiaohua Xue, Pejman Soroosh, Aimee De Leon-Tabaldo, Rosa Luna-Roman, Marciano Sablad, Natasha Rozenkrants, Jingxue Yu, Glenda Castro, Homayon Banie, Wai-Ping Fung-Leung, Luis Santamaria-Babi, Thomas Schlueter, Michael Albers, Kristi Leonard, Alison L Budelsky, Anne M Fourie
The IL-23/IL-17 pathway is implicated in autoimmune diseases, particularly psoriasis, where biologics targeting IL-23 and IL-17 have shown significant clinical efficacy. Retinoid-related orphan nuclear receptor gamma t (RORγt) is required for Th17 differentiation and IL-17 production in adaptive and innate immune cells. We identified JNJ-54271074, a potent and highly-selective RORγt inverse agonist, which dose-dependently inhibited RORγt-driven transcription, decreased co-activator binding and promoted interaction with co-repressor protein...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904016/the-measurement-of-meloxicam-and-meloxicam-metabolites-in-rat-plasma-using-a-high-performance-liquid-chromatography-ultraviolet-spectrophotometry-method
#5
Aoi Miyamoto, Takahiko Aoyama, Yoshiaki Matsumoto
A high-performance liquid chromatography-ultraviolet spectrophotometry (HPLC-UV) method for the determination of meloxicam (MEL) and meloxicam metabolites (5'-hydroxy meloxicam (5-HMEL) and 5'-carboxy meloxicam (5-CMEL)) has been developed. After extraction of MEL, 5-HMEL, and 5-CMEL from rat plasma using Oasis HLB cartridges, the extracts were separated with a Luna C18 (2) 100 A column (5 μm, 4.6 × 150 mm, Phenomenex) using a mobile phase of 50 mM phosphate buffer (pH 2.15, solvent A) and acetonitrile (solvent B) at a flow rate of 0...
December 1, 2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27902590/genotypic-distribution-of-hhv-8-in-aids-individuals-without-and-with-kaposi-sarcoma-is-genotype-b-associated-with-better-prognosis-of-aids-ks
#6
Tania Regina Tozetto-Mendoza, Karim Yaqub Ibrahim, Adriana Fumie Tateno, Cristiane Mendes de Oliveira, Laura Massami Sumita, Maria Carmem Arroyo Sanchez, Expedito José Luna, Ligia Camara Pierrotti, Jan Felix Drexler, Paulo Henrique Braz-Silva, Claudio Sérgio Pannuti, Camila Malta Romano
AIDS-associated Kaposi's sarcoma (AIDS-KS) caused by human herpes virus 8 (HHV-8) is the most severe and resistant form of KS tumor. Our aim was to verify whether there is an association between HHV-8 variability and development of AIDS-KS in Brazil by comparing the HHV-8 variability between individuals without and with KS. Saliva samples and blood, when available, were analyzed by polymerase chain reaction (PCR) techniques for detection of the fragments of ORF K1 of HHV-8, which were then genotyped and analyzed regarding the genetic variability...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27901055/mediboost-a-patient-stratification-tool-for-interpretable-decision-making-in-the-era-of-precision-medicine
#7
Gilmer Valdes, José Marcio Luna, Eric Eaton, Charles B Simone, Lyle H Ungar, Timothy D Solberg
Machine learning algorithms that are both interpretable and accurate are essential in applications such as medicine where errors can have a dire consequence. Unfortunately, there is currently a tradeoff between accuracy and interpretability among state-of-the-art methods. Decision trees are interpretable and are therefore used extensively throughout medicine for stratifying patients. Current decision tree algorithms, however, are consistently outperformed in accuracy by other, less-interpretable machine learning models, such as ensemble methods...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900604/assessment-of-interstitial-lung-disease-in-sj%C3%A3-gren-s-syndrome-by-lung-ultrasound-a-pilot-study-of-correlation-with-high-resolution-chest-tomography
#8
Pablo Guisado Vasco, Gonzalo de Luna Cardenal, Isabel Martín Garrido, José Manuel Luque Pinilla, Guadalupe Fraile Rodríguez, Juan José Nava Mateo, Daniel Carnevalli Ruiz
The background of this study is to assess the accuracy of lung ultrasound (LUS) to diagnose interstitial lung disease (ILD) in Sjögren's syndrome (Sjs), in patients who have any alterations in pulmonary function tests (PFT) or respiratory symptoms. LUS was correlated with chest tomography (hrCT), considering it as the imaging gold standard technique to diagnose ILD. This is a pilot, multicenter, cross-sectional, and consecutive-case study. The inclusion criteria are ≥18 years old, Signs and symptoms: according to ACEG 2002 criteria, respiratory symptoms (dyspnea, cough), or any alterations in PFR...
November 29, 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27893826/macro-scale-patterns-in-upwelling-downwelling-activity-at-north-american-west-coast
#9
Romeo Saldívar-Lucio, Emanuele Di Lorenzo, Miguel Nakamura, Héctor Villalobos, Daniel Lluch-Cota, Pablo Del Monte-Luna
The seasonal and interannual variability of vertical transport (upwelling/downwelling) has been relatively well studied, mainly for the California Current System, including low-frequency changes and latitudinal heterogeneity. The aim of this work was to identify potentially predictable patterns in upwelling/downwelling activity along the North American west coast and discuss their plausible mechanisms. To this purpose we applied the min/max Autocorrelation Factor technique and time series analysis. We found that spatial co-variation of seawater vertical movements present three dominant low-frequency signals in the range of 33, 19 and 11 years, resembling periodicities of: atmospheric circulation, nodal moon tides and solar activity...
2016: PloS One
https://www.readbyqxmd.com/read/27889871/genetic-relationships-and-spatial-genetic-structure-among-populations-of-rhodnius-prolixus-hemiptera-reduviidae-in-colombia-and-venezuela-based-on-mitochondrial-cytochrome-b-sequences
#10
K P Luna-Marín, V M Angulo-Silva, J Hernández-Torres, M Ruiz-García
One hundred twenty Rhodnius prolixus (Stal) (Hemiptera: Reduviidae) specimens from 6 Colombian Departments and 1 Venezuelan State had 594-bp of the mitochondrial cytochrome-b gene sequenced to improve the understanding of evolutionary processes that shape the main vector of Chagas disease. The levels of genetic diversity for this species were low-medium with reference to other bugs. The genetic heterogeneity among the populations was very limited which means there has been extensive gene flow and/or very recent split processes...
November 26, 2016: Neotropical Entomology
https://www.readbyqxmd.com/read/27887591/a-prospective-cohort-study-to-assess-seroprevalence-incidence-knowledge-attitudes-and-practices-willingness-to-pay-for-vaccine-and-related-risk-factors-in-dengue-in-a-high-incidence-setting
#11
Ruth Aralí Martínez-Vega, Alfonso J Rodriguez-Morales, Yalil Tomás Bracho-Churio, Mirley Enith Castro-Salas, Fredy Galvis-Ovallos, Ronald Giovanny Díaz-Quijano, María Lucrecia Luna-González, Jaime E Castellanos, José Ramos-Castañeda, Fredi Alexander Diaz-Quijano
BACKGROUND: Dengue is one of the most important vector-borne diseases in the world, causing significant morbidity and economic impact. In Colombia, dengue is a major public health problem. Departments of La Guajira, Cesar and Magdalena are dengue endemic areas. The objective of this research is to determine the seroprevalence and the incidence of dengue virus infection in the participating municipalities from these Departments, and also establish the association between individual and housing factors and vector indices with seroprevalence and incidence...
November 25, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27883210/rationale-and-design-of-the-bayes-interatrial-block-and-yearly-events-registry
#12
Manuel Martínez-Sellés, Adrian Baranchuk, Roberto Elosua, Antonio Bayés de Luna
The prevalence of interatrial block (IAB) is high in the elderly, particularly in those with heart disease. Despite this high prevalence-and the association of IAB with the risk of atrial fibrillation (AF), stroke, and cognitive decline-little information exists about the prognosis of older patients with IAB. P-wave duration and morphology are associated with risk of developing AF, stroke, and cognitive decline in elderly patients with structural heart disease. The aim of the Interatrial Block and Yearly Events (BAYES) registry is to assess the impact of IAB on the risk of AF and stroke during 3 years of follow-up...
November 24, 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/27877163/diversification-of-the-vacas1m1-and-vacas2m2-strains-of-helicobacter-pylori-in-meriones-unguiculatus
#13
Sandra Mendoza-Elizalde, Nancy K Arteaga-Resendiz, Pedro Valencia-Mayoral, Raúl C Luna, Sarbelio Moreno-Espinosa, Francisco Arenas-Huertero, Gerardo Zúñiga, Norma Velázquez-Guadarrama
The bacterium Helicobacter pylori exhibits great genetic diversity, and the pathogenic roles of its virulence factors have been widely studied. However, the evolutionary dynamics of H. pylori strains during stomach colonization are not well-characterized. Here, we analyzed the microevolutionary dynamics of the toxigenic strain vacAs1m1, the non-toxigenic strain vacAs2m2, and a combination of both strains in an animal model over time. Meriones unguiculatus were inoculated with the following bacteria: group 1-toxigenic strain vacAs1m1/cagA+/cagE+/babA2+; ST181, group 2-non-toxigenic strain vacAs2m2/cagA+/cagE+/babA2+; ST2901, and group 3-both strains...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27876999/outbreak-of-notozothecium-bethae-monogenea-dactylogyridae-in-myleus-schomburgkii-actinopterygii-characiformes-cultured-in-the-peruvian-amazon
#14
A F Gonzales, P D Mathews, L E Luna, J D Mathews
The presence of Notozothecium bethae was investigated in 76 black band myleus (Myleus schomburgkii [Actinopterygii: Charasiformes]) born and kept in captivity in two semi-intensive breeding cages in the northern region of Peru. Among the 76 cultivated specimens of M. schomburgkii examined in the present study, 100 % had monogenean on the gill and the parasites were identified as Notozothecium bethae. During the survey no bacteria was isolated, and no protozoan or other metazoan parasites were found. The prevalence of N...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876169/-bacillus-isolates-from-rhizosphere-of-cacti-improve-germination-and-bloom-in-mammillaria-spp-cactaceae
#15
Lluvia A Chávez-Ambriz, Alejandro Hernández-Morales, José A Cabrera-Luna, Laura Luna-Martínez, Juan R Pacheco-Aguilar
Cacti are the most representative vegetation of arid zones in Mexico where rainfall is scarce, evapotranspiration is high and soil fertility is low. Plants have developed physiological strategies such as the association with microorganisms in the rhizosphere zone to increase nutrient uptake. In the present work, four bacterial isolates from the rhizosphere of Mammillaria magnimamma and Coryphantha radians were obtained and named as QAP3, QAP19, QAP22 and QAP24, and were genetically identified as belonging to the genus Bacillus, exhibiting in vitro biochemical properties such as phosphate solubilization, indoleacetic acid production and ACC deaminase activity related to plant growth promotion, which was tested by inoculating M...
November 18, 2016: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/27872130/a-first-in-human-phase-i-study-of-the-atp-competitive-akt-inhibitor-ipatasertib-gdc-0068-demonstrates-robust-and-safe-targeting-of-akt-in-patients-with-solid-tumors
#16
Cristina Saura, Desamparados Roda, Susana Roselló, Mafalda Oliveira, Teresa Macarulla, José Alejandro Pérez-Fidalgo, Rafael Morales-Barrera, Juan Manuel Sanchis-García, Luna Musib, Nageshwar Budha, Jin Zhu, Michelle Nannini, Wai Y Chan, Sandra M Sanabria Bohórquez, Raymond D Meng, Kui Lin, Yibing Yan, Premal Patel, José Baselga, Josep Tabernero, Andres Cervantes
Activation of Akt signaling by PTEN loss or PIK3CA mutations occurs frequently in human cancers but targeting Akt has been difficult due to the mechanism-based toxicities of inhibitors that target the inactive conformation of Akt. Ipatasertib (GDC‑0068) is a novel selective ATP-competitive small molecule inhibitor of Akt that preferentially targets active phosphorylated Akt and is potent in cell lines with evidence of Akt activation. In this Phase I study, ipatasertib was well-tolerated; most adverse events were gastrointestinal and Grade 1-2 in severity...
November 21, 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27871221/most-of-the-tight-positional-conservation-of-transcription-factor-binding-sites-near-the-transcription-start-site-reflects-their-co-localization-within-regulatory-modules
#17
Natalia Acevedo-Luna, Leonardo Mariño-Ramírez, Armand Halbert, Ulla Hansen, David Landsman, John L Spouge
BACKGROUND: Transcription factors (TFs) form complexes that bind regulatory modules (RMs) within DNA, to control specific sets of genes. Some transcription factor binding sites (TFBSs) near the transcription start site (TSS) display tight positional preferences relative to the TSS. Furthermore, near the TSS, RMs can co-localize TFBSs with each other and the TSS. The proportion of TFBS positional preferences due to TFBS co-localization within RMs is unknown, however. ChIP experiments confirm co-localization of some TFBSs genome-wide, including near the TSS, but they typically examine only a few TFs at a time, using non-physiological conditions that can vary from lab to lab...
November 21, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27871060/involvement-of-serum-glucocorticoid-regulated-kinase-1-in-reproductive-success
#18
REVIEW
Yiyun Lou, Minhao Hu, Luna Mao, Yingming Zheng, Fan Jin
Reproductive processes, in particular events that concern pregnancy, are fine-tuned to produce offspring. Reproductive success is of prime importance for the survival of every species. The highly conserved and ubiquitously expressed serum glucocorticoid-regulated kinase 1 (SGK1) was first implicated in infertility as a regulator of a Na(+) channel. In this review, we emphasize the prominent role of SGK1 during early pregnancy: 1) balancing uterine luminal fluid secretion and reabsorption to aid blastocyst adhesion and to import nutrients and energy; 2) transducing signals from the blastocyst to the receptive endometrium; 3) inducing multiple genes that are involved in uterine receptivity and trophoblast invasion; 4) regulating cell differentiation and antioxidant defenses at the fetomaternal interface; and 5) contributing to the proliferation and survival of decidual stromal cells...
November 9, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27869983/microcephaly-in-brazil-prevalence-and-characterization-of-cases-from-the-information-system-on-live-births-sinasc-2000-2015
#19
Fatima Marinho, Valdelaine Etelvina Miranda de Araújo, Denise Lopes Porto, Helena Luna Ferreira, Marta Roberta Santana Coelho, Roberto Carlos Reyes Lecca, Helio de Oliveira, Ivana Pereira de Almeida Poncioni, Maria Helian Nunes Maranhão, Yluska Myrna Meneses Brandão E Mendes, Roberto Men Fernandes, Raquel Barbosa de Lima, Dácio de Lyra Rabello
OBJECTIVE: to describe the prevalence coefficients and characterize cases of microcephaly at birth in Brazil from 2000-2015. METHODS: this is a descriptive study with data from the Information System on Live Births (Sinasc). The coefficients were calculated by region and characteristics of mothers and live births (LB). RESULTS: the annual average number of microcephaly cases was 164 for the period 2000-2014, whilst in 2015, 1,608 cases were registered (54...
October 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27869968/classification-of-transmission-risk-of-vaccine-preventable-diseases-based-on-vaccination-indicators-in-brazilian-municipalities
#20
Rui Moreira Braz, Carla Magda Allan S Domingues, Antônia Maria da Silva Teixeira, Expedito José de Albuquerque Luna
OBJECTIVE: to describe the transmission risk classification of vaccine-preventable diseases in Brazilian municipalities. METHODS: this was a descriptive epidemiologic study using 2014 data of the Brazilian National Immunization Program Information System; the vaccine coverage indicators were used to classify the transmission risk of vaccine-preventable diseases in the municipalities. RESULTS: of the 5,570 Brazilian municipalities, 12.0% were classified as very low risk, 29...
October 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
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