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JOURNAL ARTICLE
Eva Grill, Vincent Darrouzet, Ulrich Mansmann, Christian Chabbert
Vestibular problems are frequent reasons for primary care consultations. However, there is considerable uncertainty about the prevalence and cost of vestibular disorders. Despite ambiguous effectiveness data, the histamine analogue betahistine is widely and almost exclusively used for treatment of vertigo. Prescription of betahistine can, therefore, be used as a proxy estimate for prevalence. We used openly available claims data from the French health insurance data warehouse, defining annual prevalence of vestibular disease as the number of people who received at least one betahistine prescription that year...
May 10, 2024: Journal of Neurology
#22
JOURNAL ARTICLE
Hamza Salim, Basel Musmar, Nimer Adeeb, Vivek Yedavalli, Dhairya Lakhani, Sahibjot Singh Grewal, Kareem El Naamani, Nils Henninger, Sri Hari Sundararajan, Anna Luisa Kühn, Jane Khalife, Sherief Ghozy, Luca Scarcia, Benjamin Yq Tan, Robert W Regenhardt, Jeremy J Heit, Nicole M Cancelliere, Joshua D Bernstock, Aymeric Rouchaud, Jens Fiehler, Sunil Sheth, Ajit S Puri, Christian Dyzmann, Marco Colasurdo, Xavier Barreau, Leonardo Renieri, João Pedro Filipe, Pablo Harker, Răzvan Alexandru Radu, Mohamad Abdalkader, Piers Klein, Thomas R Marotta, Julian Spears, Takahiro Ota, Ashkan Mowla, Pascal Jabbour, Arundhati Biswas, Frédéric Clarençon, James E Siegler, Thanh N Nguyen, Ricardo Varela, Amanda Baker, Muhammed Amir Essibayi, David Altschul, Nestor R Gonzalez, Markus A Möhlenbruch, Vincent Costalat, Benjamin Gory, Christian Paul Stracke, Mohammad Ali Aziz-Sultan, Constantin Hecker, Hamza Shaikh, David S Liebeskind, Alessandro Pedicelli, Andrea M Alexandre, Illario Tancredi, Tobias D Faizy, Erwah Kalsoum, Boris Lubicz, Aman B Patel, Vitor Mendes Pereira, Adrien Guenego, Adam A Dmytriw
BACKGROUND: Stroke remains a major health concern globally, with oral anticoagulants widely prescribed for stroke prevention. The efficacy and safety of mechanical thrombectomy (MT) in anticoagulated patients with distal medium vessel occlusions (DMVO) are not well understood. METHODS: This retrospective analysis involved 1282 acute ischemic stroke (AIS) patients who underwent MT in 37 centers across North America, Asia, and Europe from September 2017 to July 2023...
May 10, 2024: European Stroke Journal
#23
REVIEW
Sadia Bagagnan, Sabrina Guérin-Rechdaoui, Vincent Rocher, Vanessa Alphonse, Régis Moilleron, My Dung Jusselme
Microorganisms play an important role in maintaining the proper functioning of river ecosystems and are promising candidates for environmental indicators. They are also highly sensitive to environmental changes. It is necessary to have basic knowledge about them in order to know the ecological status of river ecosystem. To our knowglege, there is very little information on the status of microorganisms in surface water of the Seine River, although the Seine River is one of the rivers that suffers the greatest impact from humain activities in the world due to a weak dilution effect...
May 15, 2024: Heliyon
#24
JOURNAL ARTICLE
Jente R A Boen, Andreas B Gevaert, Amélie Dendooven, Dustin Krüger, Michiel Tubeeckx, Jens Van Fraeyenhove, Tine Bruyns, Vincent F M Segers, Emeline M Van Craenenbroeck
AIMS: MiR-181c-5p overexpression associates with heart failure (HF) and cardiac damage, but the underlying pathophysiology remains unclear. This study investigated the effect of miR-181c-5p inhibition on cardiac function and fibrosis in a rodent model of diastolic dysfunction, and evaluated additional effects on kidney as relevant comorbid organ. METHODS AND RESULTS: Diastolic dysfunction was induced in male C57/BL6J mice ( n = 20) by combining high-fat diet, L-NG-nitroarginine methyl ester, and angiotensin II administration, and was compared to sham controls ( n = 18)...
2024: Frontiers in Cardiovascular Medicine
#25
REVIEW
Vincent Thomas-de-Montpréville, Lara Chalabreysse, Véronique Hofman, Anne de-Muret, Damien Sizaret, Romain Dubois, Nicolas Piton, Audrey Mansuet-Lupo, Thierry J Molina
Micronodular arrangement of epithelial cells and lymphoid B-cell hyperplasia with follicles are both peculiar histological features in thymic tissue. Such features may especially occur in thymic epithelial tumors. The most common form is called micronodular thymoma with lymphoid stroma. We have recently described some characteristics of thymic micronodular carcinoma with lymphoid hyperplasia, highlighting how this carcinomatous counterpart should not be misdiagnosed as a thymoma. In this review, we discuss these two entities but also other mimics, which may occur in the anterior mediastinum...
May 2, 2024: Histology and Histopathology
#26
REVIEW
Faisal N Masud, Farzan Sasangohar, Iqbal Ratnani, Sahar Fatima, Marco Antonio Hernandez, Teal Riley, Jason Fischer, Atiya Dhala, Megan E Gooch, Konya Keeling-Johnson, Jukrin Moon, Jean-Louis Vincent
Healthcare systems are large contributors to global emissions, and intensive care units (ICUs) are a complex and resource-intensive component of these systems. Recent global movements in sustainability initiatives, led mostly by Europe and Oceania, have tried to mitigate ICUs' notable environmental impact with varying success. However, there exists a significant gap in the U.S. knowledge and published literature related to sustainability in the ICU. After a narrative review of the literature and related industry standards, we share our experience with a Green ICU initiative at a large hospital system in Texas...
May 9, 2024: Critical Care: the Official Journal of the Critical Care Forum
#27
JOURNAL ARTICLE
Nicholas Schmoke, Christopher Nemeh, Yeu Sanz Wu, Terri Wilken, Pengchen Wang, Paul Kurlansky, Alexis Maddocks, Chia-Ling Nhan-Chang, Russell Miller, Lynn L Simpson, Vincent Duron
OBJECTIVE: Fetal head and neck masses can result in critical airway obstruction. Our study aimed to evaluate prenatal factors associated with the decision for a definitive airway, including ex-utero intrapartum treatment (EXIT), at birth among at-risk fetuses. METHODS: A single-institution retrospective review evaluated all fetal head and neck masses prenatally diagnosed from 2005 to 2023. The primary outcome was the decision for a definitive airway at birth, including intubation, tracheostomy, or EXIT...
May 9, 2024: Prenatal Diagnosis
#28
JOURNAL ARTICLE
Antoine Daina, Vincent Zoete
Estimating protein targets of compounds based on the similarity principle-similar molecules are likely to show comparable bioactivity-is a long-standing strategy in drug research. Having previously quantified this principle, we present here a large-scale evaluation of its predictive power for inferring macromolecular targets by reverse screening an unprecedented vast external test set of more than 300,000 active small molecules against another bioactivity set of more than 500,000 compounds. We show that machine-learning can predict the correct targets, with the highest probability among 2069 proteins, for more than 51% of the external molecules...
May 9, 2024: Communications Chemistry
#29
JOURNAL ARTICLE
Hongjun Bai, Eric Lewitus, Yifan Li, Paul V Thomas, Michelle Zemil, Mélanie Merbah, Caroline E Peterson, Thujitha Thuraisamy, Phyllis A Rees, Agnes Hajduczki, Vincent Dussupt, Bonnie Slike, Letzibeth Mendez-Rivera, Annika Schmid, Erin Kavusak, Mekhala Rao, Gabriel Smith, Jessica Frey, Alicea Sims, Lindsay Wieczorek, Victoria Polonis, Shelly J Krebs, Julie A Ake, Sandhya Vasan, Diane L Bolton, M Gordon Joyce, Samantha Townsley, Morgane Rolland
An effective HIV-1 vaccine must elicit broadly neutralizing antibodies (bnAbs) against highly diverse Envelope glycoproteins (Env). Since Env with the longest hypervariable (HV) loops is more resistant to the cognate bnAbs than Env with shorter HV loops, we redesigned hypervariable loops for updated Env consensus sequences of subtypes B and C and CRF01_AE. Using modeling with AlphaFold2, we reduced the length of V1, V2, and V5 HV loops while maintaining the integrity of the Env structure and glycan shield, and modified the V4 HV loop...
May 9, 2024: Nature Communications
#30
JOURNAL ARTICLE
Christopher Lischer, Martin Eberhardt, Cindy Flamann, Johannes Berges, Esther Güse, Anja Wessely, Adrian Weich, Jimmy Retzlaff, Jan Dörrie, Niels Schaft, Manuel Wiesinger, Johannes März, Beatrice Schuler-Thurner, Harald Knorr, Shailendra Gupta, Krishna Pal Singh, Gerold Schuler, Markus Vincent Heppt, Elias Andreas Thomas Koch, Nadine D van Kleef, Julian J Freen-van Heeren, Annelies W Turksma, Olaf Wolkenhauer, Bettina Hohberger, Carola Berking, Heiko Bruns, Julio Vera
BACKGROUND: Tumor-associated antigens and their derived peptides constitute an opportunity to design off-the-shelf mainline or adjuvant anti-cancer immunotherapies for a broad array of patients. A performant and rational antigen selection pipeline would lay the foundation for immunotherapy trials with the potential to enhance treatment, tremendously benefiting patients suffering from rare, understudied cancers. METHODS: We present an experimentally validated, data-driven computational pipeline that selects and ranks antigens in a multipronged approach...
May 9, 2024: Journal for Immunotherapy of Cancer
#31
JOURNAL ARTICLE
Yutaka Endo, Diamantis I Tsilimigras, Muhammad M Munir, Selamawit Woldesenbet, Jason Yang, Alfredo Guglielmi, Francesca Ratti, Hugo P Marques, François Cauchy, Vincent Lam, George A Poultsides, Minoru Kitago, Irinel Popescu, Sorin Alexandrescu, Guillaume Martel, Ana Gleisner, Tom Hugh, Luca Aldrighetti, Feng Shen, Itaru Endo, Timothy M Pawlik
BACKGROUND: We sought to elucidate the impact of postoperative complications on patient outcomes relative to differences in alpha-fetoprotein-tumor burden score (ATS) among patients with hepatocellular carcinoma (HCC). METHODS: Patients who underwent resection of HCC between 2000 and 2020 were identified from an international database. Moderate/severe complications were defined using the optimal cut-off value of the comprehensive complication index (CCI) based on the log-rank test...
April 27, 2024: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
#32
JOURNAL ARTICLE
Matthieu Dietz, Christel H Kamani, Colin Bousige, Vincent Dunet, Judith Delage, Vladimir Rubimbura, Marie Nicod Lalonde, Giorgio Treglia, Niklaus Schaefer, Wail Nammas, Antti Saraste, Juhani Knuuti, Nathan Mewton, John O Prior
Angiogenesis is an essential part of the cardiac repair process after myocardial infarction, but its spatiotemporal dynamics remain to be fully deciphered.68 Ga-NODAGA-Arg-Gly-Asp (RGD) is a PET tracer targeting αv β3 integrin expression, which is a marker of angiogenesis. Methods: In this prospective single-center trial, we aimed to monitor angiogenesis through myocardial integrin αv β3 expression in 20 patients with ST-segment elevation myocardial infarction (STEMI). In addition, the correlations between the expression levels of myocardial αv β3 integrin and the subsequent changes in 82 Rb PET/CT parameters, including rest and stress myocardial blood flow (MBF), myocardial flow reserve (MFR), and wall motion abnormalities, were assessed...
May 9, 2024: Journal of Nuclear Medicine
#33
JOURNAL ARTICLE
Sarah Beale, Alexei Yavlinsky, Wing Lam Erica Fong, Vincent Grigori Nguyen, Jana Kovar, Theo Vos, Sarah Wulf-Hanson, Andrew C Hayward, Ibrahim Abubakar, Robert W Aldridge
No abstract text is available yet for this article.
May 10, 2024: Epidemiology and Infection
#34
JOURNAL ARTICLE
Gabriele Vecchio, Vincent Darcos, Sylvain Le Grill, Fabien Brouillet, Yannick Coppel, Mathieu Duttine, Alessandro Pugliara, Christèle Combes, Jérémy Soulié
Silicate-based bioactive glass nano/microspheres hold significant promise for bone substitution by facilitating osteointegration through the release of biologically active ions and the formation of a biomimetic apatite layer. Cu-doping enhances properties such as pro-angiogenic and antibacterial behavior. While sol-gel methods usually yield homogeneous spherical particles for pure silica or binary glasses, synthesizing poorly aggregated Cu-doped ternary glass nano/microparticles without a secondary CuO crystalline phase remains challenging...
May 7, 2024: Acta Biomaterialia
#35
JOURNAL ARTICLE
Graham Vincent, Robert Marchand, Michael A Mont, Benjamin Harder, Hytham S Salem, Philip G Conaghan, Alan D Brett, Michael A Bowes
BACKGROUND: Osteophytes are commonly used to diagnose and guide knee osteoarthritis (OA) treatment, but their causes are unclear. Although they are not typically the focus of knee arthroplasty surgeons, they can predict case difficulty and length. Furthermore, their extent and location may yield much information about the knee joint status. The aims of this computed tomography (CT)-based study in patients awaiting total or partial knee arthroplasty were to: (1) measure osteophyte volume in anatomical sub-regions and relative change as total volume increases; (2) determine whether medial and/or lateral OA affects osteophyte distribution; and (3) explore relationships between osteophytes and OA severity...
May 7, 2024: Journal of Arthroplasty
#36
JOURNAL ARTICLE
Tadahiko Seo, Anthony M Lowery, Haifang Xu, William Giang, Sergey M Troyanovsky, Peter A Vincent, Andrew P Kowalczyk
Cadherin family proteins play a central role in epithelial and endothelial cell-cell adhesion. The dynamic regulation of cell adhesion is achieved in part through endocytic membrane trafficking pathways that modulate cadherin cell surface levels. Here, we define the role for various MARCH family ubiquitin ligases in the regulation of cadherin degradation. We find that MARCH2 selectively downregulates VE-cadherin, resulting in loss of adherens junction proteins at cell borders and a loss of endothelial barrier function...
2024: PloS One
#37
JOURNAL ARTICLE
Assia Samri, Antonio Carlos Bandeira, Luana Leandro Gois, Carlos Gustavo Regis Silva, Alice Rousseau, Aurelien Corneau, Nadine Tarantino, Christopher Maucourant, Gabriel Andrade Nonato Queiroz, Vincent Vieillard, Hans Yssel, Gubio Soares Campos, Silvia Sardi, Brigitte Autran, Maria Fernanda Rios Grassi
BACKGROUND: In most cases, Zika virus (ZIKV) causes a self-limited acute illness in adults, characterized by mild clinical symptoms that resolve within a few days. Immune responses, both innate and adaptive, play a central role in controlling and eliminating virus-infected cells during the early stages of infection. AIM: To test the hypothesis that circulating T cells exhibit phenotypic and functional activation characteristics during the viremic phase of ZIKV infection...
2024: PloS One
#38
MULTICENTER STUDY
Barend M Mol, Maarten C Verwer, Rob Fijnheer, Jasper Florie, Oscar A Groot, Falco Hietbrink, Mathilde Nijkeuter, Evert-Jan P A Vonken, Vincent van Weel, Dominique P V de Kleijn, Gert J de Borst
INTRODUCTION: The risk of major bleeding complications in catheter directed thrombolysis (CDT) for acute limb ischemia (ALI) remains high, with reported major bleeding complication rates in up to 1 in every 10 treated patients. Fibrinogen was the only predictive marker used for bleeding complications in CDT, despite the lack of high quality evidence to support this. Therefore, recent international guidelines recommend against the use of fibrinogen during CDT. However, no alternative biomarkers exist to effectively predict CDT-related bleeding complications...
2024: PloS One
#39
JOURNAL ARTICLE
Gregory B Waypa, Kimberly A Smith, Paul T Mungai, Vincent J Dudley, Kathryn A Helmin, Benjamin D Singer, Clara Bien Peek, Joseph Bass, Lauren Beussink-Nelson, Sanjiv J Shah, Gaston Ofman, J Andrew Wasserstrom, William A Muller, Alexander V Misharin, G R Scott Budinger, Hiam Abdala-Valencia, Navdeep S Chandel, Danijela Dokic, Elizabeth T Bartom, Shuang Zhang, Yuki Tatekoshi, Amir Mahmoodzadeh, Hossein Ardehali, Edward B Thorp, Paul T Schumacker
Newborn mammalian cardiomyocytes quickly transition from a fetal to an adult phenotype that utilizes mitochondrial oxidative phosphorylation but loses mitotic capacity. We tested whether forced reversal of adult cardiomyocytes back to a fetal glycolytic phenotype would restore proliferative capacity. We deleted Uqcrfs1 (mitochondrial Rieske Iron-Sulfur protein, RISP) in hearts of adult mice. As RISP protein decreased, heart mitochondrial function declined, and glucose utilization increased. Simultaneously, they underwent hyperplastic remodeling during which cardiomyocyte number doubled without cellular hypertrophy...
May 9, 2024: Journal of Clinical Investigation
#40
JOURNAL ARTICLE
Vincent De Coninck, Laura Hendrickx, Xavier Mortiers, Bhaskar Somani, Esteban Emiliani, Emre Tarik Sener, Amelia Pietropaolo, Patrick Jones, Andreas Skolarikos, Thomas Tailly, Stefan De Wachter, Olivier Traxer, Etienne Xavier Keller
INTRODUCTION: Ionizing radiation is used daily during endourological procedures. Despite the dangers of both deterministic and stochastic effects of radiation, there is a lack of knowledge and awareness among urologists. This study reviewed the literature to identify the radiation exposure (RE) of urologists during endourological procedures. METHODS: A literature search of the Medline, Web of Science, and Google Scholar databases was conducted to collect articles related to the radiation dose to urologists during endourological procedures...
May 9, 2024: World Journal of Urology
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