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https://www.readbyqxmd.com/read/29169182/gemcitabine-plus-platinum-based-chemotherapy-for-first-line-treatment-of-hepatocholangiocarcinoma-an-ageo-french-multicentre-retrospective-study
#1
Maëva Salimon, Caroline Prieux-Klotz, David Tougeron, Vincent Hautefeuille, Morgane Caulet, Jérôme Gournay, Tamara Matysiak-Budnik, Jaafar Bennouna, Manuela Tiako Meyo, Thierry Lecomte, Aziz Zaanan, Yann Touchefeu
BACKGROUND: Hepatocholangiocarcinoma (cHCC-ICC) is a rare liver tumour for which no data on chemosensitivity exist. The aims of this multicentre study were to evaluate overall survival (OS), progression-free survival (PFS), and prognostic factors in cHCC-ICC treated by gemcitabine plus platinum as first-line. METHODS: Unresectable cHCC-ICC treated by gemcitabine plus platinum-based chemotherapy between 2008 and 2017 were retrospectively analysed. Diagnosis was based on histology or, in case of ICC or HCC histology, on discordant computerised tomography scan enhancement patterns associated with discordant serum tumour marker elevation suggesting the alternative tumour...
November 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29168908/the-rickiols-20-22-and-24-membered-macrolides-from-the-ascomycete-hypoxylon-rickii
#2
Frank Surup, Eric Kuhnert, Andreas Böhm, Vincent Wiebach, Danny Solga, Hauke Engler, Tim Pendzialek, Albrecht Berkessel, Marc Stadler, Markus Kalesse
In preceding studies the neotropical ascomycete Hypoxylon rickii turned out to be a prolific source of new secondary metabolites since we had obtained terpenoids with five different scaffolds besides a series of terphenyls. From the mycelial extracts of a 70 L scale fermentation of this strain we additionally isolated nine new macrolides (1 - 9) by RP-HPLC. Their planar structures were elucidated by NMR spectroscopy complemented by HR-ESIMS. The relative configurations were assigned by J-based configuration analyses and confirmed by Kishi's universal database...
November 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29168715/emission-of-hydrogen-sulfide-h2s-at-a-waterfall-in-a-sewer-study-of-main-factors-affecting-h2s-emission-and-modeling-approaches
#3
Daniel Jung, Laetitia Hatrait, Julien Gouello, Arnaud Ponthieux, Vincent Parez, Christophe Renner
Hydrogen sulfide (H2S) represents one of the main odorant gases emitted from sewer networks. A mathematical model can be a fast and low-cost tool for estimating its emission. This study investigates two approaches to modeling H2S gas transfer at a waterfall in a discharge manhole. The first approach is based on an adaptation of oxygen models for H2S emission at a waterfall and the second consists of a new model. An experimental set-up and a statistical data analysis allowed the main factors affecting H2S emission to be studied...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29168669/awake-craniotomy-versus-craniotomy-under-general-anesthesia-for-the-surgical-treatment-of-insular-glioma-choices-and-outcomes
#4
B Y Gravesteijn, M E Keizer, A J P E Vincent, J W Schouten, R J Stolker, M Klimek
OBJECTIVE: To investigate differences in outcomes in patients who underwent surgery for insular glioma using an awake craniotomy (AC) vs. a craniotomy under general anesthesia (GA). METHODS: Data from patients treated at our hospital between 2005 and 2015 were analyzed retrospectively. The preoperative, intraoperative, postoperative, and longer term follow-up characteristics and outcomes of patients who underwent surgery for primary insular glioma using either an AC or GA were compared...
November 23, 2017: Neurological Research
https://www.readbyqxmd.com/read/29168593/respiratory-regulation-by-steroids-in-newborn-rats-a-sex-specific-balance-between-allopregnanolone-and-progesterone-receptors
#5
Vincent Joseph, NagaPraveena Uppari, Hayet Kouchi, Celia De Bruyn, Ryma Boukari, Aida Bairam
We tested the hypothesis that the effects of progesterone on apnoea frequency in newborn rats are the result of a balance between its neuroactive metabolite allopregnanolone (GABAa receptor modulator) and progesterone receptors. We used male and female rats between 10 and 12 days of age and recorded respiratory and metabolic parameters (whole-body plethysmography), and assessed the frequency and duration of apnoeas under normoxia. We tested the effects of a single injection of progesterone (4 mg kg(-1) , i...
November 23, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29168483/bicyclic-baird-type-aromaticity
#6
Won-Young Cha, Taeyeon Kim, Arindam Ghosh, Zhan Zhang, Xian-Sheng Ke, Rashid Ali, Vincent M Lynch, Jieun Jung, Woojae Kim, Sangsu Lee, Shunichi Fukuzumi, Jung Su Park, Jonathan L Sessler, Tavarekere K Chandrashekar, Dongho Kim
Classic formulations of aromaticity have long been associated with topologically planar conjugated macrocyclic systems. The theoretical possibility of so-called bicycloaromaticity was noted early on. However, it has yet to be demonstrated by experiment in a simple synthetic organic molecule. Conjugated organic systems are attractive for studying the effect of structure on electronic features. This is because, in principle, they can be modified readily through dedicated synthesis. As such, they can provide useful frameworks for testing by experiment with fundamental insights provided by theory...
December 2017: Nature Chemistry
https://www.readbyqxmd.com/read/29168297/single-suture-craniosynostosis-identification-of-rare-variants-in-genes-associated-with-syndromic-forms
#7
Christine M Clarke, Vincent T Fok, Jennifer A Gustafson, Matthew D Smyth, Andrew E Timms, Chris D Frazar, Joshua D Smith, Craig B Birgfeld, Amy Lee, Richard G Ellenbogen, Joseph S Gruss, Richard A Hopper, Michael L Cunningham
We report RNA-Sequencing results on a cohort of patients with single suture craniosynostosis and demonstrate significant enrichment of heterozygous, rare, and damaging variants among key craniosynostosis-related genes. Genetic burden analysis identified a significant increase in damaging variants in ATR, EFNA4, ERF, MEGF8, SCARF2, and TGFBR2. Of 391 participants, 15% were found to have damaging and potentially causal variants in 29 genes. We observed transmission in 96% of the affected individuals, and thus penetrance, epigenetics, and oligogenic factors need to be considered when recommending genetic testing in patients with nonsyndromic craniosynostosis...
November 23, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29167833/disorder-specific-and-shared-brain-abnormalities-during-vigilance-in-autism-and-obsessive-compulsive-disorder
#8
Christina O Carlisi, Luke Norman, Clodagh M Murphy, Anastasia Christakou, Kaylita Chantiluke, Vincent Giampietro, Andrew Simmons, Michael Brammer, Declan G Murphy, David Mataix-Cols, Katya Rubia
Background: Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) are often comorbid and share similarities across some cognitive phenotypes, including certain aspects of attention. However, no functional magnetic resonance imaging studies have compared the underlying neural mechanisms contributing to these shared phenotypes. Methods: Age- and IQ-matched boys (11-17 years old) with ASD (n = 20), boys with OCD (n = 20), and healthy control boys (n = 20) performed a parametrically modulated psychomotor vigilance functional magnetic resonance imaging task...
November 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29167645/improving-cardiometabolic-health-with-diet-physical-activity-and-breaking-up-sitting-what-about-sleep
#9
Grace E Vincent, Sarah M Jay, Charli Sargent, Corneel Vandelanotte, Nicola D Ridgers, Sally A Ferguson
Cardiometabolic disease poses a serious health and economic burden worldwide and its prevalence is predicted to increase. Prolonged sitting, lack of physical activity, poor diet, and short sleep duration are ubiquitous behaviors in modern society, and all are independent risk factors in the development of cardiometabolic disease. Existing evidence demonstrates that breaking up prolonged periods of sitting is beneficial for cardiometabolic health, however, studies have not controlled for prior sleep duration...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29167476/levodopa-induced-abnormal-involuntary-movements-correlate-with-altered-permeability-of-the-blood-brain-barrier-in-the-basal-ganglia
#10
Renata P Lerner, Veronica Francardo, Koji Fujita, Zisis Bimpisidis, Vincent A Jourdain, Chris C Tang, Stephen L Dewey, Thomas Chaly, M Angela Cenci, David Eidelberg
Chronic levodopa treatment leads to the appearance of dyskinesia in the majority of Parkinson's disease patients. Neurovascular dysregulation in putaminal and pallidal regions is thought to be an underlying feature of this complication of treatment. We used microPET to study unilaterally lesioned 6-hydroxydopamine rats that developed levodopa-induced abnormal involuntary movements (AIMs) after three weeks of drug treatment. Animals were scanned with [(15)O]-labeled water and [(18)F]-fluorodeoxyglucose, to map regional cerebral blood flow and glucose metabolism, and with [(11)C]-isoaminobutyric acid (AIB), to assess blood-brain-barrier (BBB) permeability, following separate injections of levodopa or saline...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167465/coupling-of-polo-kinase-activation-to-nuclear-localization-by-a-bifunctional-nls-is-required-during-mitotic-entry
#11
David Kachaner, Damien Garrido, Haytham Mehsen, Karine Normandin, Hugo Lavoie, Vincent Archambault
The Polo kinase is a master regulator of mitosis and cytokinesis conserved from yeasts to humans. Polo is composed of an N-term kinase domain (KD) and a C-term polo-box domain (PBD), which regulates its subcellular localizations. The PBD and KD can interact and inhibit each other, and this reciprocal inhibition is relieved when Polo is phosphorylated at its activation loop. How Polo activation and localization are coupled during mitotic entry is unknown. Here we report that PBD binding to the KD masks a nuclear localization signal (NLS)...
November 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/29167439/eroded-telomeres-are-rearranged-in-quiescent-fission-yeast-cells-through-duplications-of-subtelomeric-sequences
#12
Laetitia Maestroni, Julien Audry, Samah Matmati, Benoit Arcangioli, Vincent Géli, Stéphane Coulon
While the mechanisms of telomere maintenance has been investigated in dividing cells, little is known about the stability of telomeres in quiescent cells and how dysfunctional telomeres are processed in non-proliferating cells. Here we examine the stability of telomeres in quiescent cells using fission yeast. While wild type telomeres are stable in quiescence, we observe that eroded telomeres were highly rearranged during quiescence in telomerase minus cells. These rearrangements depend on homologous recombination (HR) and correspond to duplications of subtelomeric regions...
November 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/29166946/noise-exposure-while-commuting-in-toronto-a-study-of-personal-and-public-transportation-in-toronto
#13
Christopher M K L Yao, Andrew K Ma, Sharon L Cushing, Vincent Y W Lin
BACKGROUND: With an increasing proportion of the population living in cities, mass transportation has been rapidly expanding to facilitate the demand, yet there is a concern that mass transit has the potential to result in excessive exposure to noise, and subsequently noise-induced hearing loss. METHODS: Noise dosimetry was used to measure time-integrated noise levels in a representative sample of the Toronto Mass Transit system (subway, streetcar, and buses) both aboard moving transit vehicles and on boarding platforms from April - August 2016...
November 23, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29166414/chraso-the-chromate-efflux-pump-of-shewanella-oneidensis-improves-chromate-survival-and-reduction
#14
Hiba Baaziz, Cyril Gambari, Anne Boyeldieu, Amine Ali Chaouche, Radia Alatou, Vincent Méjean, Cécile Jourlin-Castelli, Michel Fons
The chromate efflux pump encoding gene chrASO was identified on the chromosome of Shewanella oneidensis MR1. Although chrASO is expressed without chromate, its expression level increases when Cr(VI) is added. When deleted, the resulting mutant ΔchrASO exhibits a chromate sensitive phenotype compared to that of the wild-type strain. Interestingly, heterologous expression of chrASO in E. coli confers resistance to high chromate concentration. Moreover, expression of chrASO in S. oneidensis and E. coli significantly improves Cr(VI) reduction...
2017: PloS One
https://www.readbyqxmd.com/read/29166045/controlling-relative-polymorph-stability-in-soft-porous-crystals-with-a-barostat
#15
Nathan A Mahynski, Vincent K Shen
We use Monte Carlo simulations to investigate the thermodynamic behavior of soft porous crystal (SPC) adsorbents under the influence of an external barostat. We consider SPCs that naturally exhibit polymorphism between crystal forms of two distinct pore sizes. In the absence of barostatting, these crystals may be naturally divided into two categories depending on their response to stress applied by the adsorbate fluid: those which macroscopically deform and change the volume of their unit cell ("breathing") and those which instead undergo internal rearrangements that change the adsorbate-accessible volume without modifying the unit cell volume ("gate-opening")...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29164977/a-retrospective-matched-paired-analysis-comparing-bendamustine-containing-beeam-versus-beam-conditioning-regimen-results-from-a-single-center-experience
#16
Khalil Saleh, Alina Danu, Serge Koscielny, Clémence Legoupil, Sylvain Pilorge, Cristina Castilla-Llorente, David Ghez, Julien Lazarovici, Jean-Marie Michot, Nadine Khalife-Saleh, Valerie Lapierre, Kamelia Alenxandrova, Julia Arfi-Rouche, Jean-Henri Bourhis, Vincent Ribrag
The combination of carmustine, etoposide, aracytin, and melphalan(BEAM) conditioning regimen in autologous stem-cell transplantation (ASCT) is widely used in patients with relapsed/refractory non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma. It is also an option in patients with very-high risk aggressive NHL in first complete remission (CR). Recently, a phase Ib-II feasibility study using bendamustine replacing carmustine (BCNU) was reported. We report herein a safety and efficacy analysis of bendamustine-EAM (BeEAM) with a control BEAM counterpart paired cohort (1/2)...
November 22, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29164735/substituting-the-target-after-unsatisfactory-outcome-of-deep-brain-stimulation-in-advanced-parkinson-s-disease-cases-from-the-nstaps-trial-and-systematic-review-of-the-literature
#17
Timo R Ten Brinke, Vincent J J Odekerken, Teus van Laar, J Marc C van Dijk, Joke M Dijk, Pepijn van den Munckhof, P Rick Schuurman, Rob M A de Bie
BACKGROUND: Deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) and the subthalamic nucleus (STN) are established treatment option in Parkinson's disease (PD). If DBS does not provide the desired effect, re-operation to the alternative target is a treatment option, but data on the effect of re-operation are scarce. OBJECTIVES: The objective of this study is to evaluate the clinical effect of re-operation the alternative target after failure of initial STN or GPi DBS for Parkinson's disease...
November 22, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29164006/guest-editor-s-message-tripler-army-medical-center-research-symposium
#18
Dale S Vincent
No abstract text is available yet for this article.
November 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/29163578/transpiration-response-and-growth-in-pearl-millet-parental-lines-and-hybrids-bred-for-contrasting-rainfall-environments
#19
Susan Medina, S K Gupta, Vincent Vadez
Under conditions of high vapor pressure deficit (VPD) and soil drying, restricting transpiration is an important avenue to gain efficiency in water use. The question we raise in this article is whether breeding for agro-ecological environments that differ for the rainfall have selected for traits that control plant water use. These are measured in pearl millet materials bred for zones varying in rainfall (8 combinations of parent and F1-hybrids, 18 F1-hybrids and then 40 F1-hybrids). In all cases, we found an agro-ecological variation in the slope of the transpiration response to increasing VPD, and parental line variation in the transpiration response to soil drying within hybrids/parent combinations...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29163490/immune-checkpoint-molecules-on-tumor-infiltrating-lymphocytes-and-their-association-with-tertiary-lymphoid-structures-in-human-breast-cancer
#20
Cinzia Solinas, Soizic Garaud, Pushpamali De Silva, Anaïs Boisson, Gert Van den Eynden, Alexandre de Wind, Paolo Risso, Joel Rodrigues Vitória, François Richard, Edoardo Migliori, Grégory Noël, Hugues Duvillier, Ligia Craciun, Isabelle Veys, Ahmad Awada, Vincent Detours, Denis Larsimont, Martine Piccart-Gebhart, Karen Willard-Gallo
There is an exponentially growing interest in targeting immune checkpoint molecules in breast cancer (BC), particularly in the triple-negative subtype where unmet treatment needs remain. This study was designed to analyze the expression, localization, and prognostic role of PD-1, PD-L1, PD-L2, CTLA-4, LAG3, and TIM3 in primary BC. Gene expression analysis using the METABRIC microarray dataset found that all six immune checkpoint molecules are highly expressed in basal-like and HER2-enriched compared to the other BC molecular subtypes...
2017: Frontiers in Immunology
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