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https://www.readbyqxmd.com/read/27922878/higher-fluid-balance-increases-the-risk-of-death-from-sepsis-results-from-a-large-international-audit
#1
Yasser Sakr, Paolo Nahuel Rubatto Birri, Katarzyna Kotfis, Rahul Nanchal, Bhagyesh Shah, Stefan Kluge, Mary E Schroeder, John C Marshall, Jean-Louis Vincent
OBJECTIVES: Excessive fluid therapy in patients with sepsis may be associated with risks that outweigh any benefit. We investigated the possible influence of early fluid balance on outcome in a large international database of ICU patients with sepsis. DESIGN: Observational cohort study. SETTING: Seven hundred and thirty ICUs in 84 countries. PATIENTS: All adult patients admitted between May 8 and May 18, 2012, except admissions for routine postoperative surveillance...
December 5, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27922854/identification-of-hiv-infection-related-dna-methylation-sites-and-advanced-epigenetic-aging-in-hiv-treatment-na%C3%A3-ve-u-s-veterans
#2
Kristin N Nelson, Qin Hui, David Rimland, Ke Xu, Matthew S Freiberg, Amy C Justice, Vincent C Marconi, Yan V Sun
OBJECTIVE: HIV-positive individuals are at higher risk than healthy persons for aging-related diseases, including myocardial infarction and non-AIDS defining cancers. Recent evidence suggests that HIV infection may modulate changes in the host cell epigenome, and these changes represent a potential mechanism through which HIV infection accelerates aging. We assessed the difference in DNAm age, an aging marker involving multiple age-related CpG sites, among antiretroviral treatment (ART) naïve HIV-positive and HIV-negative individuals in a cohort of veterans from the Veterans Aging Cohort Study (VACS)...
December 5, 2016: AIDS
https://www.readbyqxmd.com/read/27922642/threshold-values-for-the-perception-of-color-changes-in-human-teeth
#3
Daniel S Thoma, Alexis Ioannidis, Vincent Fehmer, Gioia Michelotti, Ronald E Jung, Irena Sailer
The aim of the present study was to assess the threshold values for color changes on the level of the tooth separately for laypeople, dentists, and dental technicians. Standardized presentations were made of five cases (maxilla, left to right lateral incisors) with the gingiva and teeth separated. The color parameters L (lightness), a, and b (chroma) (CIE L*a*b* parameters) of the tooth layers were adjusted to induce darker and lighter colors. In the presentations, the left part of the pictures (maxillary right central and lateral incisors) was unchanged, whereas the right part was modified...
November 2016: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/27922193/phagocytosis-of-collagen-fibrils-by-fibroblasts-in-vivo-is-independent-of-the-uparap-endo180-receptor
#4
Sara Sprangers, Niels Behrendt, Lars Engelholm, Yixuan Cao, Vincent Everts
As a crucial step in ECM remodeling, collagen degradation occurs through different processes, including both extracellular and intracellular degradation. The extracellular pathways of collagen degradation require secretion of collagenolytic proteases, whereas intracellular collagen degradation occurs in the lysosomal compartment after uptake, involving either pre-cleaved or intact fibrillar collagen. The endocytic collagen receptor uPARAP/Endo180 plays an important role in internalization of large collagen degradation products, whereas its role in the phagocytosis of fibrillar collagen has been debated...
December 6, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27921344/uhplc-ms-based-hdac-assay-applied-to-bio-guided-microfractionation-of-fungal-extracts
#5
Vincent Zwick, Pierre-Marie Allard, Lucie Ory, Claudia A Simões-Pires, Laurence Marcourt, Katia Gindro, Jean-Luc Wolfender, Muriel Cuendet
INTRODUCTION: Histone deacetylases (HDAC) are considered as promising targets for cancer treatment. Today, four HDAC inhibitors, vorinostat, romidepsin, belinostat, and panobinostat, have been approved by the Food and Drug Administration (FDA) for cancer treatment, while others are in clinical trials. Among them, several are naturally occurring fungal metabolites. OBJECTIVE: To develop and optimise an enzyme assay for bio-guided identification of HDAC inhibitors in fungal strains...
December 5, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/27921255/health-education-policies-to-maximize-the-effectiveness-of-human-resources-for-health-programs-in-low-income-countries
#6
EDITORIAL
Cameron Page, Vincent Sugira
No abstract text is available yet for this article.
December 5, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27921158/long-term-outcome-of-percutaneous-alcohol-embolization-combined-with-percutaneous-vertebroplasty-in-aggressive-vertebral-hemangiomas-with-epidural-extension
#7
Kévin Premat, Frédéric Clarençon, Évelyne Cormier, Jugurtha Mahtout, Raphaël Bonaccorsi, Vincent Degos, Jacques Chiras
OBJECTIVES: To evaluate, on a long-term basis, the safety and effectiveness of percutaneous alcohol embolization (PAE) combined with percutaneous vertebroplasty (PVP) as a sole treatment for aggressive vertebral haemangiomas (AVHs) with epidural extension. METHODS: From 1996 to 2015, 26 consecutive patients (15 women [58%] and 11 men; mean age 51.8 years [range: 19-75 years]) underwent PAE combined with PVP (performed at day 15) for the treatment of 27 AVHs with epidural extension...
December 5, 2016: European Radiology
https://www.readbyqxmd.com/read/27920970/a-review-and-treatment-selection-model-for-individuals-with-developmental-disabilities-who-engage-in-inappropriate-sexual-behavior
#8
Tonya N Davis, Wendy Machalicek, Rachel Scalzo, Alicia Kobylecky, Vincent Campbell, Sarah Pinkelman, Jeffrey Michael Chan, Jeff Sigafoos
Some individuals with developmental disabilities develop inappropriate sexual behaviors such as public masturbation, disrobing, and touching others in an unwanted sexual manner. Such acts are problematic given the taboo nature of the behaviors and the potential for significant negative consequences, such as restricted community access, injury, and legal ramifications. Therefore, it is necessary to equip caregivers and practitioners with effective treatment options. The purpose of this paper is to review studies that have evaluated behavioral treatments to reduce inappropriate sexual behavior in persons with developmental disabilities...
December 2016: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/27920964/the-apprentice-an-innovative-approach-to-meet-the-behavior-analysis-certification-board-s-supervision-standards
#9
Breanne K Hartley, William T Courtney, Mary Rosswurm, Vincent J LaMarca
The Behavior Analysis Certification Board continues to increase the standards for supervision of trainees, which is needed in order for the field to continually improve. However, this presents a challenge for organizations to meet the needs of both their clients and their supervisees based on these increasing standards. Throughout the ages, experts in all trades have passed along their knowledge and skill through apprenticeship opportunities. An apprenticeship supervision model is described that allows Board Certified Behavior Analysts to supervise future behavior analysts by mentoring, educating, and training supervisees on the science of human behavior in a format that is mutually beneficial...
December 2016: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/27920726/hrvanalysis-a-free-software-for-analyzing-cardiac-autonomic-activity
#10
Vincent Pichot, Frédéric Roche, Sébastien Celle, Jean-Claude Barthélémy, Florian Chouchou
Since the pioneering studies of the 1960s, heart rate variability (HRV) has become an increasingly used non-invasive tool for examining cardiac autonomic functions and dysfunctions in various populations and conditions. Many calculation methods have been developed to address these issues, each with their strengths and weaknesses. Although, its interpretation may remain difficult, this technique provides, from a non-invasive approach, reliable physiological information that was previously inaccessible, in many fields including death and health prediction, training and overtraining, cardiac and respiratory rehabilitation, sleep-disordered breathing, large cohort follow-ups, children's autonomic status, anesthesia, or neurophysiological studies...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27920717/cataract-surgery-with-a-new-fluidics-control-phacoemulsification-system-in-nanophthalmic-eyes
#11
John S M Chang, Jack C M Ng, Vincent K C Chan, Antony K P Law
PURPOSE: To report visual outcomes and complications after cataract surgery in nanophthalmic eyes with a phacoemulsification system using the active fluidics control strategy. METHODS: This is a retrospective case series. All eyes with an axial length of less than 20 mm that underwent cataract surgery or refractive lens exchange using the Centurion Vision System (Alcon Laboratories Inc.) in Hong Kong Sanatorium and Hospital were evaluated. The visual acuity and intraoperative and postoperative complications were reported...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/27920547/predictive-value-of-nt-probnp-for-30-day-mortality-in-patients-with-non-st-elevation-acute-coronary-syndromes-a-comparison-with-the-grace-and-timi-risk-scores
#12
Dirk Aam Schellings, Ahmet Adiyaman, Jan-Henk E Dambrink, At Marcel Gosselink, Elvin Kedhi, Vincent Roolvink, Jan Paul Ottervanger, Arnoud Wj Van't Hof
BACKGROUND: The biomarker N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts outcome in patients with non-ST-elevation acute coronary syndromes (NSTE-ACS). Whether NT-proBNP has incremental prognostic value beyond established risk strategies is still questionable. PURPOSE: To evaluate the predictive value of NT-proBNP for 30-day mortality over and beyond the Global Registry of Acute Coronary Events (GRACE) and Thrombolysis In Myocardial Infarction (TIMI) risk scores in patients with NSTE-ACS...
2016: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/27920355/initiation-of-addiction-treatment-and-access-to-services-young-adults-accounts-of-their-help-seeking-experiences
#13
Vincent Wagner, Karine Bertrand, Jorge Flores-Aranda, Didier Acier, Natacha Brunelle, Michel Landry, Serge Brochu
Substance addiction in young adults is particularly problematic. Yet, much remain at stake in understanding the specifics of this population's access to services. The objective of this study is to explore young adults' initiation of substance misuse treatment. Our study sample was composed of 35 individuals aged 18 to 30 with problematic psychoactive substance use who have been identified in criminal courts, hospital emergency departments, and Health and Social Services Centers in Québec (Canada). A thematic analysis was performed on the 62 semi-structured interviews conducted with participants...
December 4, 2016: Qualitative Health Research
https://www.readbyqxmd.com/read/27919517/centrifugal-partition-chromatography-a-preparative-tool-for-isolation-and-purification-of-xylindein-from-chlorociboria-aeruginosa
#14
Anukul Boonloed, Genevieve L Weber, Kelly M Ramzy, Veronica R Dias, Vincent T Remcho
A centrifugal partition chromatography (CPC) method was developed for the preparative-scale isolation and purification of xylindein from the wood-staining fungi, Chlorociboria aeruginosa. Xylindein, a blue-green pigment naturally secreted from the hyphae and fruiting bodies of the fungus, has great value in the decorative wood industry and textile coloration. Xylindein has great potential for use as a fluorescent labeling agent as well as in organic semiconductor applications. However, a primary limitation of xylindein is its poor solubility in most common HPLC solvents...
November 18, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27919269/comparison-of-voluntary-food-intake-and-palatability-of-commercial-weight-loss-diets-in-healthy-dogs-and-cats
#15
Marie Anne Hours, Emmanuelle Sagols, Ariane Junien-Castagna, Alexandre Feugier, Delphine Moniot, Ingrid Daniel, Vincent Biourge, Serisier Samuel, Yann Queau, Alexander J German
BACKGROUND: Obesity in dogs and cats is usually managed by dietary energy restriction using a purpose-formulated weight loss diet, but signs of hunger and begging commonly occur causing poor owner compliance. Altering diet characteristics so as to reduce voluntary food intake (VFI) can improve the likelihood of success, although this should not be at the expense of palatability. The aim of the current study was to compare the VFI and palatibility of novel commercially available canine and feline weight loss diets...
December 5, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27919184/role-of-engineered-metal-oxide-nanoparticle-agglomeration-in-reactive-oxygen-species-generation-and-cathepsin-b-release-in-nlrp3-inflammasome-activation-and-pulmonary-toxicity
#16
Tina M Sager, Michael Wolfarth, Stephen S Leonard, Anna M Morris, Dale W Porter, Vincent Castranova, Andrij Holian
Incomplete understanding of the contributions of dispersants and engineered nanoparticles/materials (ENM) agglomeration state to biological outcomes presents an obstacle for toxicological studies. Although reactive oxygen species (ROS) production is often regarded as the primary indicator of ENM bioactivity and toxicity, it remains unclear whether ENM produce ROS or whether ROS is an outcome of ENM-induced cell injury. Phagolysosomal disruption and cathepsin B release also promote bioactivity through inflammasome activation...
December 5, 2016: Inhalation Toxicology
https://www.readbyqxmd.com/read/27918993/tetrahydropyranodiquinolin-8-amines-as-new-non-hepatotoxic-antioxidant-and-acetylcholinesterase-inhibitors-for-alzheimer-s-disease-therapy
#17
Youssef Dgachi, Olga Sokolov, Vincent Luzet, Justyna Godyń, Dawid Panek, Alexandre Bonet, Hélène Martin, Isabel Iriepa, Ignacio Moraleda, Cristina García-Iriepa, Jana Janockova, Lysiane Richert, Ondrej Soukup, Barbara Malawska, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Herein we report an efficient two step synthesis and biological assessment of 12 racemic tetrahydropyranodiquinolin-8-amines derivatives as antioxidant, cholinesterase inhibitors and non-hepatotoxic agents. Based on the results of the primary screening, we identified 7-(3-methoxyphenyl)-9,10,11,12-tetrahydro-7H-pyrano[2,3-b:5,6-h']diquinolin-8-amine (2h) as a particularly interesting non-hepatotoxic compound that shows moderate antioxidant activity (1.83 equiv Trolox in the ORAC assay), a non competitive inhibition of hAChE (IC50 = 0...
November 23, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27918827/optic-radiations-microstructural-changes-in-glaucoma-and-association-with-severity-a-study-using-3tesla-magnetic-resonance-diffusion-tensor-imaging
#18
Laury Tellouck, Muriel Durieux, Pierrick Coupé, Audrey Cougnard-Grégoire, Joy Tellouck, Thomas Tourdias, Fanny Munsch, Arnaud Garrigues, Catherine Helmer, Florence Malet, Jean-François Dartigues, Vincent Dousset, Cécile Delcourt, Cédric Schweitzer
Purpose: To compare microstructural changes along the optical radiations and brain structure volumes between glaucoma and control subjects using in vivo magnetic resonance imaging and to analyze their association with severity of the disease. Methods: A total of 50 open-angle glaucoma subjects and 50 healthy age- and sex-matched controls underwent detailed ophthalmologic examinations (including visual field testing [VF], funduscopy, and spectral-domain optical coherence tomography) as well as diffusion tensor imaging (DTI) using 3...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27918762/alternating-treatment-with-pazopanib-and-everolimus-vs-continuous-pazopanib-to-delay-disease-progression-in-patients-with-metastatic-clear-cell-renal-cell-cancer-the-ropetar-randomized-clinical-trial
#19
Geert A Cirkel, Paul Hamberg, Stefan Sleijfer, Olaf J L Loosveld, M Wouter Dercksen, Maartje Los, Marco B Polee, Franchette van den Berkmortel, Maureen J Aarts, Laurens V Beerepoot, Gerard Groenewegen, Martijn P Lolkema, Metin Tascilar, Johanna E A Portielje, Frank P J Peters, Heinz-Josef Klümpen, Vincent van der Noort, John B A G Haanen, Emile E Voest
Importance: To our knowledge, this is the first randomized clinical trial evaluating an alternating treatment regimen in an attempt to delay disease progression in clear cell renal cell carcinoma. Objective: To test our hypothesis that an 8-week rotating treatment schedule with pazopanib and everolimus delays disease progression, exhibits more favorable toxic effects, and improves quality of life when compared with continuous treatment with pazopanib. Design, Setting, and Participants: This was an open-label, randomized (1:1) study (ROPETAR trial)...
December 1, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27918669/the-within-season-distribution-of-external-training-and-racing-workload-in-professional-male-road-cyclist
#20
Alan J Metcalfe, Paolo Menaspà, Vincent Villerius, Marc Quod, Jeremiah J Peiffer, Andrew D Govus, Chris R Abbiss
PURPOSE: To describe the within-season external workloads of professional male road cyclists for optimal training prescription. METHODS: Training and racing of four international competitive professional male cyclists (age 24 ± 2 y, body mass 77.6 ± 1.5 kg) were monitored for 12 months prior to the world team time trial championships. Three within-season phases leading up to the team time trial world championships on 20(th) Sept 2015 were defined as phase one (Oct - Jan), phase two (Feb - May) and phase three (June - Sept)...
December 5, 2016: International Journal of Sports Physiology and Performance
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