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https://www.readbyqxmd.com/read/28222310/circulating-mirna-associated-with-posttraumatic-stress-disorder-in-a-cohort-of-military-combat-veterans
#1
Christiana G Martin, Hyungsuk Kim, Sijung Yun, Whitney Livingston, Joseph Fetta, Vincent Mysliwiec, Tristin Baxter, Jessica M Gill
Posttraumatic stress disorder (PTSD) affects many returning combat veterans, but underlying biological mechanisms remain unclear. In order to compare circulating micro RNA (miRNA) of combat veterans with and without PTSD, peripheral blood from 24 subjects was collected following deployment, and isolated miRNA was sequenced. PTSD was associated with 8 differentially expressed miRNA. Pathway analysis shows that PTSD is related to the axon guidance and Wnt signaling pathways, which work together to support neuronal development through regulation of growth cones...
January 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28221777/rhenium-complexes-based-on-2-pyridyl-1-2-3-triazole-ligands-a-new-class-of-co2-reduction-catalysts
#2
H Y Vincent Ching, Xia Wang, Menglan He, Noemi Perujo Holland, Régis Guillot, Cyrine Slim, Sophie Griveau, Hélène C Bertrand, Clotilde Policar, Fethi Bedioui, Marc Fontecave
A series of [Re(N^N)(CO)3(X)] (N^N = diimine and X = halide) complexes based on 4-(2-pyridyl)-1,2,3-triazole (pyta) and 1-(2-pyridyl)-1,2,3-triazole (tapy) diimine ligands have been prepared and electrochemically characterized. The first ligand-based reduction process is shown to be highly sensitive to the nature of the isomer as well as to the substituents on the pyridyl ring, with the peak potential changing by up to 700 mV. The abilities of this class of complexes to catalyze the electroreduction and photoreduction of CO2 were assessed for the first time...
February 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28220918/cadmium-complexes-bearing-me2-n-e-o-e-s-se-organochalcogenoalkoxides-and-their-zinc-and-mercury-analogues
#3
Alexandra Pop, Clément Bellini, Răzvan Şuteu, Vincent Dorcet, Thierry Roisnel, Jean-François Carpentier, Anca Silvestru, Yann Sarazin
Heteroleptic zinc and cadmium complexes of the type [{(Me2)N^E^O(R2)}M-Nu]n (M = Zn, Cd; E = S, Se; R = CH3, CF3; Nu = N(SiMe3)2, I, Cl; n = 1-2) were prepared by reacting the alcohol proteo-ligands {(Me2)N^E^O(R2)}H with [M(N(SiMe3)2)2] (M = Zn, Cd) or [XMN(SiMe3)2] (M = Zn, X = Cl; M = Cd, X = I) in an equimolar ratio. These group 12 metal complexes were characterised in solution by multinuclear NMR spectroscopy and their solid-state structures were determined by X-ray diffractometry. The ligands {(Me2)N^E^O((CH3)2)}(-) bearing CH3 groups in α position to the alkoxide behave as κ(2)-O,E-bidentate moieties (E = S, Se) and form centro-symmetric dinuclear O-bridged heteroleptic alkoxo-amido complexes both with zinc and cadmium, with four-coordinate metal centres resting in tetrahedral environments...
February 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28220772/tumour-and-host-cell-pd-l1-is-required-to-mediate-suppression-of-anti-tumour-immunity-in-mice
#4
Janet Lau, Jeanne Cheung, Armando Navarro, Steve Lianoglou, Benjamin Haley, Klara Totpal, Laura Sanders, Hartmut Koeppen, Patrick Caplazi, Jacqueline McBride, Henry Chiu, Rebecca Hong, Jane Grogan, Vincent Javinal, Robert Yauch, Bryan Irving, Marcia Belvin, Ira Mellman, Jeong M Kim, Maike Schmidt
Expression of PD-L1, the ligand for T-cell inhibitory receptor PD-1, is one key immunosuppressive mechanism by which cancer avoids eradication by the immune system. Therapeutic use of blocking antibodies to PD-L1 or its receptor PD-1 has produced unparalleled, durable clinical responses, with highest likelihood of response seen in patients whose tumour or immune cells express PD-L1 before therapy. The significance of PD-L1 expression in each cell type has emerged as a central and controversial unknown in the clinical development of immunotherapeutics...
February 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28220594/time-resolved-x-ray-powder-diffraction-study-of-photoinduced-phase-transition-in-ti3o5-nanoparticles
#5
Kelin Regina Tasca, Vincent Esposito, Gabriel Lantz, Paul Beaud, Martin Kubli, Matteo Savoini, Carlos Giles, Steven L Johnson
Nanoparticles of Ti3O5 have been reported to show a permanent photoinduced phase transition at room temperature. This suggests that light-induced phase transformations of Ti3O5 nanoparticles may be promising for technological applications. Here we report a photoinduced semiconductor-to-metal phase transition from beta-Ti3O5 to lambda-Ti3O5 nanoparticles at room temperature observed directly by time-resolved x-ray powder diffraction in a pump-probe setup. The results show a partial structural change, limited by differences between pumped and probed volumes, that persists a few microseconds after excitation...
February 20, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28220583/morphometric-analysis-of-prostate-zonal-anatomy-using-magnetic-resonance-imaging-mri-the-impact-on-age-related-changes-in-japanese-and-american-populations
#6
Toru Matsugasumi, Atsuko Fujihara, So Ushijima, Motohiro Kanazawa, Yasuhiro Yamada, Takumi Shiraishi, Fumiya Hongo, Kazumi Kamoi, Koji Okihara, Andre Luis de Castro Abreu, Masakatsu Oishi, Toshitaka Shin, Suzanne Palmer, Inderbir S Gill, Osamu Ukimura
OBJECTIVES: Magnetic resonance imaging (MRI) can be used to reliably evaluate prostate zonal anatomy. Objectives of this study was to evaluate the impact of morphometric MRI analysis of the prostate zonal anatomy on aging, prostatic hypertrophy, and lower urinary tract symptoms in patients from Japan and the USA. SUBJECTS AND METHODS: A retrospective analysis of 307 men, including Japanese (n=156) and American (n=151) patients, who consecutively underwent 3-Tesla MRI and International Prostate Symptom Score (IPSS) due to elevated PSA...
February 20, 2017: BJU International
https://www.readbyqxmd.com/read/28220316/lung-cancer-diagnosed-following-an-emergency-admission-exploring-patient-and-carer-perspectives-on-delay-in-seeking-help
#7
Glenys Caswell, Jane Seymour, Vincent Crosby, Asmah Hussain, Cathann Manderson, Sarah Farnan, Sarah Freer, Alison Freemantle, Fran Littlewood, Andrew Wilcock
PURPOSE: Compared to others, patients diagnosed with lung cancer following an emergency, unplanned admission to hospital (DFEA) have more advanced disease and poorer prognosis. Little is known about DFEA patients' beliefs about cancer and its symptoms or about their help-seeking behaviours prior to admission. METHODS: As part of a larger single-centre, prospective mixed-methods study conducted in one University hospital, we undertook qualitative interviews with patients DFEA and their carers to obtain their understanding of symptoms and experiences of trying to access healthcare services before admission to hospital...
February 21, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28219822/ultrafast-acquisition-of-1-h-1-h-dipolar-correlation-experiments-in-spinning-elastomers
#8
Laetitia Rouger, Maxime Yon, Vincent Sarou-Kanian, Franck Fayon, Jean-Nicolas Dumez, Patrick Giraudeau
We show that two widely used 2D solid-state NMR (ssNMR) pulse sequences can be implemented in an ultrafast (UF) manner, and yield 2D spectra of elastomers in a single scan, under magic-angle spinning. UF 2D ssNMR provides an acceleration of one to several orders of magnitude for classic experiments.
February 9, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28219806/structural-characterization-and-viscoelastic-constitutive-modeling-of-skin
#9
Vincent R Sherman, Yizhe Tang, Shiteng Zhao, Wen Yang, Marc A Meyers
: A fascinating material, skin has a tensile response which exhibits an extended toe region of minimal stress up to nominal strains that, in some species, exceed 1, followed by significant stiffening until a roughly linear region. The large toe region has been attributed to its unique structure, consisting of a network of curved collagen fibers. Investigation of the structure of rabbit skin reveals that it consists of layers of wavy fibers, each one with a characteristic orientation. Additionally, the existence of two preferred layer orientations is suggested based on the results of small angle x-ray scattering...
February 17, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28219736/development-of-minimal-enzyme-cocktails-for-hydrolysis-of-sulfite-pulped-lignocellulosic-biomass
#10
Piotr Chylenski, Zarah Forsberg, Jerry Ståhlberg, Anikó Várnai, Martin Lersch, Oskar Bengtsson, Solve Sæbø, Svein Jarle Horn, Vincent G H Eijsink
Despite recent progress, saccharification of lignocellulosic biomass is still a major cost driver in biorefining. In this study, we present the development of minimal enzyme cocktails for hydrolysis of Norway spruce and sugarcane bagasse, which were pretreated using the so-called BALI™ process, which is based on sulfite pulping technology. Minimal enzyme cocktails were composed using several glycoside hydrolases purified from the industrially relevant filamentous fungus Trichoderma reesei and a purified commercial β-glucosidase from Aspergillus niger...
February 17, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28219667/mild-social-stress-in-mice-produces-opioid-mediated-analgesia-in-visceral-but-not-somatic-pain-states
#11
M H Pitcher, R Gonzalez-Cano, K Vincent, M Lehmann, E J Cobos, T J Coderre, J M Baeyens, F Cervero
: Visceral pain has a greater emotional component than somatic pain. To determine if the stress-induced analgesic response is differentially expressed in visceral versus somatic pain states, we studied the effects of a mild social stressor in either acute visceral or somatic pain states in mice. We show that the presence of an unfamiliar conspecific (stranger) in an adjacent cubicle of a standard transparent observation box produced elevated plasma corticosterone levels compared to mice tested alone, suggesting that the mere presence of a stranger is stressful...
February 17, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28219613/no-room-for-hyperoxia-or-hypertonic-saline-in-septic-shock
#12
Jean-Louis Vincent
No abstract text is available yet for this article.
February 14, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28219032/analysis-of-the-semg-force-relationship-using-hd-semg-technique-and-data-fusion-a-simulation-study
#13
Mariam Al Harrach, Vincent Carriou, Sofiane Boudaoud, Jeremy Laforet, Frederic Marin
The relationship between the surface Electromyogram (sEMG) signal and the force of an individual muscle is still ambiguous due to the complexity of experimental evaluation. However, understanding this relationship should be useful for the assessment of neuromuscular system in healthy and pathological contexts. In this study, we present a global investigation of the factors governing the shape of this relationship. Accordingly, we conducted a focused sensitivity analysis of the sEMG/force relationship form with respect to neural, functional and physiological parameters variation...
February 16, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28219029/versatile-transduction-scheme-based-on-electrolyte-gated-organic-field-effect-transistor-used-as-immunoassay-readout-system
#14
Benoît Piro, Dengjun Wang, Dihia Benaoudia, Alexandra Tibaldi, Guillaume Anquetin, Vincent Noël, Steeve Reisberg, Giorgio Mattana, Brianna Jackson
We report on an innovative heterogeneous bisphenol A (BPA) immunoassay based on an electrolyte-gated organic field-effect transistor whose organic semiconductor is poly(2,5-bis(3-tetradecylthiophen-2-yl)thieno[3,2-b]thiophene) co-crystallized with an alkyl derivative of bisphenol A. A decrease of the transistor output current is first observed upon antibody specific binding onto the organic semiconductor. Upon bisphenol A addition, the competitive dissociation of the antibody from the semiconductor surface leads to an opposite increase of the output current...
February 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28218620/endothelial-antigen-assembly-leads-to-thrombotic-complications-in-heparin-induced-thrombocytopenia
#15
Vincent Hayes, Ian Johnston, Gowthami M Arepally, Steven E McKenzie, Douglas B Cines, Lubica Rauova, Mortimer Poncz
Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder initiated by antibodies against complexes between human platelet factor 4 (hPF4) and heparin. A better understanding of the events that initiate the prothrombotic state may improve approaches to antithrombotic management. Here, we visualized thrombus formation in an in vivo murine model and an endothelialized microfluidic system that simulate the pathogenesis of HIT. hPF4 released from platelets predominantly bound to peri-injury endothelium and formed HIT antigenic complexes that were dissociated by heparin...
February 20, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28218291/a-pan-cancer-analysis-of-secreted-frizzled-related-proteins-re-examining-their-proposed-tumour-suppressive-function
#16
Krista Marie Vincent, Lynne-Marie Postovit
Secreted frizzled-related proteins (SFRPs), containing five family members (SFRPs 1-5) are putative extracellular Wnt inhibitors. Given their abilities to inhibit Wnt signalling, as well as the loss of SFRP1 in many cancers, this family is generally considered to be tumour suppressive. In this study we analyzed gene expression, promoter methylation and survival data from over 8000 tumour and normal samples from 29 cancers in order to map the context-specific associations of SFRPs 1-5 with patient survival, gene silencing and gene expression signatures...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28217714/dr-hagis-a-fundus-image-database-for-the-automatic-extraction-of-retinal-surface-vessels-from-diabetic-patients
#17
Sven Holm, Greg Russell, Vincent Nourrit, Niall McLoughlin
A database of retinal fundus images, the DR HAGIS database, is presented. This database consists of 39 high-resolution color fundus images obtained from a diabetic retinopathy screening program in the UK. The NHS screening program uses service providers that employ different fundus and digital cameras. This results in a range of different image sizes and resolutions. Furthermore, patients enrolled in such programs often display other comorbidities in addition to diabetes. Therefore, in an effort to replicate the normal range of images examined by grading experts during screening, the DR HAGIS database consists of images of varying image sizes and resolutions and four comorbidity subgroups: collectively defined as the diabetic retinopathy, hypertension, age-related macular degeneration, and Glaucoma image set (DR HAGIS)...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28217435/a-rare-fungal-infection-phaehyphomycosis-due-to-veronaea-botryosa-and-review-of-literature
#18
Anne Welfringer, Valérie Vuong, Nicolas Argy, Christian Chochillon, Lydia Deschamps, Guillaume Rollin, Stanislas Harent, Véronique Joly, William Vindrios, Vincent Descamps
We report a rare case of phaehyphomycosis in a 71-year-old heart transplant recipient Togo native patient. Four months after the transplant, he presented painless nodules on the right heel with superficial ulceration. The polyphasic identification uncovered a rare cause of phaehyphomycose: V. botryosa. The treatment combined surgical excision of the lesions and anti-fungal therapy with posaconazole. We discussed eleven reported cases in literature since 1990.
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28217388/neurosurgery-concepts-key-perspectives-on-imaging-characteristics-of-spinal-metastases-surgery-for-low-back-pain-anesthesia-for-disc-surgery-and-laminectomy-versus-laminectomy-and-fusion-for-lumbar-spondylolisthesis
#19
Carlito Lagman, Lawrance K Chung, Luke Macyszyn, Winward Choy, Zachary A Smith, Nader S Dahdaleh, Angela M Bohnen, Jin M Cho, Chaim B Colen, Edward Duckworth, Anand V Germanwala, Peter Kan, Alexander A Khalessi, Chae-Yong Kim, Sandi Lam, Gordon Li, Michael Lim, Jonathan H Sherman, Vincent Y Wang, Gabriel Zada, Isaac Yang
No abstract text is available yet for this article.
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28217316/subacute-right-heart-failure-revealing-three-simultaneous-causes-of-post-embolic-pulmonary-hypertension-in-metastatic-dissemination-of-breast-cancer
#20
Flavien Vincent, Nicolas Lamblin, Marion Classe, Guillaume Schurtz, Antoine Rauch, Marie Fertin, Pascal De Groote
A 72-year-old woman with history of breast cancer only treated surgically was referred to our department for pulmonary hypertension (PH) suspicion. Echocardiogram revealed elevated right ventricular systolic pressure. Computed tomography (CT) angiogram showed no pulmonary embolism (PE), but lung scan revealed two ventilation-perfusion mismatch areas. Right cardiac catheterization established precapillary PH. Despite treatment with PH specific therapy (sildenafil, ambrisentan, and epoprostenol), her condition worsened rapidly with acute right heart failure (RHF)...
February 2017: ESC Heart Failure
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