keyword
MENU ▼
Read by QxMD icon Read
search

Vincent

keyword
https://www.readbyqxmd.com/read/28525910/cutaneous-apocrine-carcinoma-with-an-in-situ-component-and-histiocytoid-and-signet-ring-cells
#1
Jérémie Berdugo, Vincent Dumont-Mackay, Sophie Brissy-Lachery, Yves E Leclerc, Josée Doyon, Andrew Mitchell, Tony Petrella, Delphine Désy
We present a case of cutaneous apocrine carcinoma arising in the axilla of a 71-year-old man. The tumor had a significant component of histiocytoid and signet-ring cells as well as in situ carcinoma within the apocrine glands. The cells expressed GATA3, gross cystic disease fluid protein 15, androgen receptor, and E-cadherin. Estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 were negative. Clinical correlation was required to rule out a metastasis from the breast or the gastrointestinal tract...
June 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28525556/transcriptome-of-the-gsh-depleted-lens-reveals-changes-in-detoxification-and-emt-signaling-genes-transport-systems-and-lipid-homeostasis
#2
Jeremy A Whitson, Xiang Zhang, Mario Medvedovic, Jenny Chen, Zongbo Wei, Vincent M Monnier, Xingjun Fan
Purpose: To understand the effects of glutathione (GSH)-deficiency on genetic processes that regulate lens homeostasis and prevent cataractogenesis. Methods: The transcriptome of lens epithelia and fiber cells was obtained from C57BL/6 LEGSKO (lens GSH-synthesis knockout) and buthionine sulfoximine (BSO)-treated LEGSKO mice and compared to C57BL/6 wild-type mice using RNA-Seq. Transcriptomic data were confirmed by qPCR and Western blot/ELISA on a subset of genes...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28525437/feasibility-and-parental-acceptability-of-an-8-week-slow-speed-high-intensity-community-based-resistance-training-program-for-preadolescent-children
#3
Sarah L Mullane, Vincent B Bocchicchio, Noe C Crespo
High-intensity resistance training (RT) shows promise for improved cardiometabolic health in children. Achieving high-intensity RT safely is a challenge for community-based programs because of parental concerns and group engagement. Twenty preadolescent children completed an 8-week, twice per week program using slow speed to achieve high-intensity RT. Parent and child surveys were conducted to measure acceptability and effectiveness. Child fitness levels were assessed, and fasting blood draws and dual-energy x-ray absorptiometry were performed on a subset population...
July 2017: Family & Community Health
https://www.readbyqxmd.com/read/28524182/cell-sized-mechanosensitive-and-biosensing-compartment-programmed-with-dna
#4
Sagardip Majumder, Jonathan Garamella, Ying-Lin Wang, Maxwell DeNies, Vincent Noireaux, Allen P Liu
The bottom-up construction of cell-sized compartments programmed with DNA that are capable of sensing the chemical and physical environment remains challenging in synthetic cell engineering. Here, we construct mechanosensitive liposomes with biosensing capability by expressing the E. coli channel MscL and a calcium biosensor using cell-free expression.
May 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28523940/delay-in-estrogen-commencement-is-associated-with-lower-bone-mineral-density-in-turner-syndrome
#5
H H Nguyen, P Wong, B J Strauss, G Jones, P R Ebeling, F Milat, A Vincent
OBJECTIVE: Turner syndrome (TS) is associated with hypogonadism, osteoporosis and fractures. We investigated the prevalence and risk factors for low bone density and fractures in a TS cohort. METHODS: We included 76 TS patients (median age 28.5 years) attending a tertiary hospital between 1998 and 2015 who underwent dual-energy X-ray absorptiometry. Spine and femoral neck (FN) areal bone mineral density (aBMD) were compared with those of a control group. To adjust for smaller bone size, bone mineral apparent density (BMAD) was calculated...
May 19, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28523582/first-in-human-radiation-dosimetry-of-68-ga-nodaga-rgdyk
#6
Silvano Gnesin, Periklis Mitsakis, Francesco Cicone, Emmanuel Deshayes, Vincent Dunet, Augusto F Gallino, Marek Kosinski, Sébastien Baechler, Franz Buchegger, David Viertl, John O Prior
BACKGROUND: Integrin-targeting radiopharmaceuticals have potential broad applications, spanning from cancer theranostics to cardiovascular diseases. We have previously reported preclinical dosimetry results of (68)Ga-NODAGA-RGDyK in mice. This study presents the first human dosimetry of (68)Ga-NODAGA-RGDyK in the five consecutive patients included in a clinical imaging protocol of carotid atherosclerotic plaques. Five male patients underwent whole-body time-of-flight (TOF) PET/CT scans 10, 60 and 120 min after tracer injection (200 MBq)...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28523412/epidemiological-risk-factors-for-animal-influenza-a-viruses-overcoming-species-barriers
#7
REVIEW
Kate A Harris, Gudrun S Freidl, Olga S Munoz, Sophie von Dobschuetz, Marco De Nardi, Barbara Wieland, Marion P G Koopmans, Katharina D C Stärk, Kristien van Reeth, Gwen Dauphin, Adam Meijer, Erwin de Bruin, Ilaria Capua, Andy A Hill, Rowena Kosmider, Jill Banks, Kim Stevens, Sylvie van der Werf, Vincent Enouf, Karen van der Meulen, Ian H Brown, Dennis J Alexander, Andrew C Breed
Drivers and risk factors for Influenza A virus transmission across species barriers are poorly understood, despite the ever present threat to human and animal health potentially on a pandemic scale. Here we review the published evidence for epidemiological risk factors associated with influenza viruses transmitting between animal species and from animals to humans. A total of 39 papers were found with evidence of epidemiological risk factors for influenza virus transmission from animals to humans; 18 of which had some statistical measure associated with the transmission of a virus...
May 18, 2017: EcoHealth
https://www.readbyqxmd.com/read/28523281/imaging-membrane-potential-changes-from-dendritic-spines-using-computer-generated-holography
#8
Dimitrii Tanese, Ju-Yun Weng, Valeria Zampini, Vincent De Sars, Marco Canepari, Balazs Rozsa, Valentina Emiliani, Dejan Zecevic
Electrical properties of neuronal processes are extraordinarily complex, dynamic, and, in the general case, impossible to predict in the absence of detailed measurements. To obtain such a measurement one would, ideally, like to be able to monitor electrical subthreshold events as they travel from synapses on distal dendrites and summate at particular locations to initiate action potentials. It is now possible to carry out these measurements at the scale of individual dendritic spines using voltage imaging. In these measurements, the voltage-sensitive probes can be thought of as transmembrane voltmeters with a linear scale, which directly monitor electrical signals...
July 2017: Neurophotonics
https://www.readbyqxmd.com/read/28523226/interpersonal-early-life-trauma-alters-amygdala-connectivity-and-sustained-attention-performance
#9
Francesca C Fortenbaugh, Vincent Corbo, Victoria Poole, Regina McGlinchey, William Milberg, David Salat, Joseph DeGutis, Michael Esterman
INTRODUCTION: Interpersonal early life trauma (I-ELT) is associated with a myriad of functional impairments in adulthood, increased risk of drug addiction, and neuropsychiatric disorders. While deficits in emotional regulation and amygdala functioning are well characterized, deficits in general cognitive functioning have also been documented. However, the neural underpinnings of cognitive dysfunction in adults with a history of I-ELT and the potential relationship between amygdala-based functional connectivity and behavioral performance are currently poorly understood...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28522924/use-of-the-4kscore-test-to-predict-the-risk-of-aggressive-prostate-cancer-prior-to-prostate-biopsy-overall-cost-savings-and-improved-quality-of-care-to-the-us-healthcare-system
#10
Jeffrey D Voigt, Yan Dong, Vincent Linder, Stephen Zappala
The 4Kscore® Test (BioReference Laboratories, Elmwood Park, NJ) is a blood test that accurately determines the risk of aggressive prostate cancer and significantly reduces prostate biopsies and associated overdiagnosis and overtreatment of indolent cancer. A budget impact model was developed to test the hypothesis that the 4Kscore Test can improve quality of care and deliver cost savings for patients who are suspected of having prostate cancer and would otherwise undergo prostate biopsy under the current standard of care (SOC) in the United States...
2017: Reviews in Urology
https://www.readbyqxmd.com/read/28522824/obestatin-controls-skeletal-muscle-fiber-type-determination
#11
Icía Santos-Zas, Tania Cid-Díaz, Jessica González-Sánchez, Uxía Gurriarán-Rodriguez, Carlos Seoane-Mosteiro, Begoña Porteiro, Rubén Nogueiras, Xesús Casabiell, José Luis Relova, Rosalía Gallego, Vincent Mouly, Yolanda Pazos, Jesus P Camiña
Obestatin/GPR39 signaling stimulates skeletal muscle growth and repair by inducing both G-protein-dependent and -independent mechanisms linking the activated GPR39 receptor with distinct sets of accessory and effector proteins. In this work, we describe a new level of activity where obestatin signaling plays a role in the formation, contractile properties and metabolic profile of skeletal muscle through determination of oxidative fiber type. Our data indicate that obestatin regulates Mef2 activity and PGC-1α expression...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28521657/several-inhibitors-of-the-plk1-polo-box-domain-turn-out-to-be-non-specific-protein-alkylators
#12
Vincent Archambault, Karine Normandin
For almost a decade, there has been much interest in the development of chemical inhibitors of Polo-like kinase 1 (Plk1) protein interactions. Plk1 is a master regulator of the cell division cycle that controls numerous substrates. It is a promising target for cancer drug development. Inhibitors of the kinase domain of Plk1 had some success in clinical trials. However, they are not perfectly selective. In principle, Plk1 can also be inhibited by interfering with its protein interaction domain, the Polo-Box Domain (PBD)...
May 19, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28521532/new-antivirals-for-the-treatment-of-chronic-hepatitis-b
#13
Vincent Soriano, Pablo Barreiro, Laura Benitez, Jose M Peña, Carmen de Mendoza
Current treatment with oral nucleos(t)ides entecavir or tenofovir provide sustained suppression of HBV replication and clinical benefit in most chronic hepatitis B virus (HBV) infected persons. However, HBV rebound generally occurs upon drug discontinuation due to persistence of genomic HBV reservoirs as episomic cccDNA and chromosomic integrated HBV-DNA. There is renewed enthusiasm on HBV drug discovery following recent successes with antivirals for hepatitis C and immunotherapies for some cancers. Areas covered: New drugs that target distinct steps of the HBV life cycle are been developed, including inhibitors of viral entry, new polymerase inhibitors, capsid and assembly inhibitors, virus release blockers, and disruptors of cccDNA formation and transcription...
May 18, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28521116/efficacy-of-anticonvulsant-substances-in-the-6hz-seizure-test-comparison-of-two-rodent-species
#14
Elise Esneault, Guillaume Peyon, Vincent Castagné
Usually performed in the mouse, the 6Hz seizure test is used for screening potential new anticonvulsant substances against complex partial seizures. Nevertheless, advanced models of temporal lobe epilepsy (TLE) are more often performed in rats, so that possible species-related differences may complicate the development of anticonvulsant substances. The aim of the present study was to evaluate the feasibility of adapting the 6Hz test in the rat. We first compared the effects of increasing current intensities for inducing seizures in the mouse and in the rat...
May 10, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28521091/non-magnetic-quantum-emitters-in-boron-nitride-with-ultra-narrow-and-sideband-free-emission-spectra
#15
Xiangzhi Li, Gabriella Donna Shepard, Andrew Cupo, Nicolas Camporeale, Kamran Shayan, Yue Luo, Vincent Meunier, Stefan Strauf
Hexagonal boron nitride (hBN) is an emerging material in nanophotonics and an attractive host for color centers for quantum photonic devices. Here we show that optical emission from individual quantum emitters in hBN is spatially correlated with structural defects and can display ultra-narrow zero-phonon linewidth down to 45 μeV if spectral diffusion is effectively eliminated by proper surface passivation. We demonstrate that undesired emission into phonon sidebands is largely absent for this type of emitter...
May 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/28521087/assessment-of-electron-propagator-methods-for-the-simulation-of-vibrationally-resolved-valence-and-core-photoionization-spectra
#16
Alberto Baiardi, Lorenzo Paoloni, Vincenzo Barone, Viatcheslav G Zakrzewski, Joseph Vincent Ortiz
The analysis of photoelectron spectra is usually facilitated by quantum mechanical simulations. Due to the recent improvement of experimental techniques, the resolution of experimental spectra is rapidly increasing, and the inclusion of vibrational effects is usually mandatory to obtain a reliable reproduction of the spectra. With the aim of defining a robust computational protocol, a general time-independent formulation to compute different kinds of vibrationally-resolved electronic spectra has been generalized to support also photoelectron spectroscopy...
May 18, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28521044/cross-tissue-exploration-of-genetic-and-epigenetic-effects-on-brain-gray-matter-in-schizophrenia
#17
Dongdong Lin, Jiayu Chen, Stefan Ehrlich, Juan R Bustillo, Nora Perrone-Bizzozero, Esther Walton, Vincent P Clark, Yu-Ping Wang, Jing Sui, Yuhui Du, Beng C Ho, Charles S Schulz, Vince D Calhoun, Jingyu Liu
Closely linking genetics and environment factors, epigenetics has been of increasing interest in psychiatric disease studies. In this work, we integrated single nucleotide polymorphisms (SNPs), DNA methylation of blood and saliva, and brain gray matter (GM) measures to explore the role of genetic and epigenetic variation to the brain structure changes in schizophrenia (SZ). By focusing on the reported SZ genetic risk regions, we applied a multi-stage multivariate analysis to a discovery dataset (92 SZ patients and 110 controls, blood) and an independent replication dataset (93 SZ patients and 99 controls, saliva)...
May 17, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28518188/ph-dependent-absorption-spectrum-of-a-protein-a-minimal-electrostatic-model-of-anabaena-sensory-rhodopsin
#18
Michael Stenrup, Elisa Pieri, Vincent Ledentu, Nicolas Ferré
A minimal electrostatic model is introduced which aims at reproducing and analyzing the visible-light absorption energy shift of a protein with pH. It relies on the existence of a protein structure, the prediction of titratable amino-acid pKa values and a very limited set of parameters. Applied to the case of the photochromic Anabaena sensory rhodopsin protein, the model succeeds in reproducing qualitatively the reported experimental data, confirming the importance of aspartic acid 217 in the observed blue shift in the λmax of ASR at neutral pH...
May 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28518033/distribution-and-quantitative-estimates-of-variant-creutzfeldt-jakob-disease-prions-in-tissues-of-clinical-and-asymptomatic-patients
#19
Jean Y Douet, Caroline Lacroux, Naima Aron, Mark W Head, Séverine Lugan, Cécile Tillier, Alvina Huor, Hervé Cassard, Mark Arnold, Vincent Beringue, James W Ironside, Olivier Andréoletti
In the United-Kingdom, ≈1 of 2,000 persons could be infected with variant Creutzfeldt-Jakob disease (vCJD). Therefore, risk of transmission of vCJD by medical procedures remains a major concern for public health authorities. In this study, we used in vitro amplification of prions by protein misfolding cyclic amplification (PMCA) to estimate distribution and level of the vCJD agent in 21 tissues from 4 patients who died of clinical vCJD and from 1 asymptomatic person with vCJD. PMCA identified major levels of vCJD prions in a range of tissues, including liver, salivary gland, kidney, lung, and bone marrow...
June 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28517973/periodontal-referral-patterns-in-australia-2000-versus-2015
#20
Leah M Brown, Patrick Bowman, Vincent J O'Rourke, Faustino Mercado, Roderick Marshall, Scott Parsons
BACKGROUND: A previous study had investigated differences in the severity of periodontal disease on referral for specialist care between 1980 and 2000 across the USA. This study found patients referred in 2000 had a greater severity of periodontal disease than those referred twenty years prior. METHODS: A retrospective chart analysis of 384 charts was completed from three periodontal practices across the east coast of Australia. Two time periods were investigated; 2000-2001 and 2015-2016...
May 18, 2017: Journal of Periodontology
keyword
keyword
76431
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"