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https://www.readbyqxmd.com/read/29793130/anxiety-memories-and-coping-in-patients-undergoing-intracranial-tumor-surgery
#1
Tom J van Ark, Markus Klimek, Peter de Smalen, Arnaud J P E Vincent, Robert Jan Stolker
OBJECTIVES: The diagnosis and the surgical removal of a brain tumor can have serious impact on the quality of life of a patient. The question rises, whether having more or just less memories of the procedure is better for coping with such an event. Furthermore, for preoperative information of future patients it is important to know how patients process their emotions and memories. The primary objective of this study was to investigate the link between preoperative anxiety, the perioperative experience and the quantity and quality of postoperative memories in patients who underwent intracranial tumor surgery...
May 17, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29792553/mitochondrial-complex-i-defect-resulting-from-exercise-induced-lower-limb-ischemia-in-patients-with-peripheral-arterial-disease
#2
Isabelle Signolet, Pierre Abraham, Stéphanie Chupin, Myriam Ammi, Naïg Gueguen, Franck Letournel, Jean Picquet, Christophe Baufreton, Mickael Daligault, Vincent Procaccio, Pascal Reynier, Samir Henni
OBJECTIVE: This study aims to compare the structural and mitochondrial alterations between muscle segments affected by exercise-induced ischemia and segments of the same muscle without ischemia, in the same subject. METHODS: In a prospective analysis, 34 patients presenting either peripheral arterial disease or chronic coronary syndrome without any evidence of peripheral arterial disease were eligible for inclusion based on findings indicating a need for either a femoro-popliteal bypass or a saphenous harvesting for coronary bypass...
May 24, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29792472/effects-of-exercise-on-experimentally-manipulated-craving-for-cannabis-a-preliminary-study
#3
Sandy D Wilson, R Lorraine Collins, Mark A Prince, Paula C Vincent
Cannabis is the most commonly used illicit drug in the United States, and craving for cannabis is related to cannabis use. Exercise has been demonstrated to reduce craving for substances. To examine the effects of exercise on cannabis craving, we conducted a 3-week within-subject crossover experiment. Young-adult men (n = 35) and women (n = 11), age 18-25 years (M = 20.76, SD = 1.68), who regularly (≥3 times per week) used cannabis participated in a cue exposure paradigm to stimulate craving. After each of three separate craving inductions, they completed a 10-min bout of exercise that varied in intensity (rest, moderate, vigorous)...
May 24, 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29792121/abcg2-polymorphism-rs2231142-and-hypothyroidism-in-metastatic-renal-cell-carcinoma-patients-treated-with-sunitinib
#4
Emilie Werbrouck, Julie Bastin, Diether Lambrechts, Annelies Verbiest, Thomas Van Brussel, Evelyne Lerut, Jean-Pascal Machiels, Vincent Verschaeve, Vincent Richard, Philip R Debruyne, Brigitte Decallonne, Patrick Schöffski, Oliver Bechter, Pascal Wolter, Benoit Beuselinck
Background and aim Vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) cause significant adverse events including thyroid dysfunction, mainly hypothyroidism, in a considerable proportion of patients. In a series of metastatic renal cell carcinoma (mRCC) patients treated with sunitinib, we aimed to study the correlation between hypothyroidism and single nucleotide polymorphisms (SNPs) in genes involved in sunitinib pharmacokinetics and pharmacodynamics. Patients and methods We included 79 mRCC patients who started sunitinib between November 2005 and March 2016...
May 23, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29792094/regulatory-context-and-validation-of-assays-for-clinical-mass-spectrometry-proteomics-cmsp-methods
#5
Christophe Hirtz, Pauline Bros, Cato Brede, Pierre Lescuyer, Aleksandra M Maceski, Jerome Vialaret, Vincent Delatour, Sylvain Lehmann
Clinical mass spectrometry proteomics (cMSP) assays are being increasingly used in clinical laboratories for analyzing peptides and proteins. It has therefore become urgent to characterize and validate the methods available for liquid chromatography-tandem mass spectrometry (LC/MS-MS) targeted quantification of peptide and protein biomarkers in biological fluids in the context of in vitro diagnostics. LC-MS/MS for the detection of peptides and proteins is currently the main approach used in the field of cMSP...
May 23, 2018: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29791761/nerve-action-potential-amplitudes-a-robust-marker-of-diabetic-peripheral-neuropathy
#6
Marie Monlun, Marie Hugo, Laurence Blanco, Kamel Mohammedi, Ahdab Rechdi, Laure Alexandre, Stéphane Poirot-Mazeres, Kalina Rajaobelina, Vincent Rigalleau
We were interested in the recent publication of Peterson et al. (1) who reported a progressive reduction of sural nerve amplitudes from 10.9μV to 7.0μV, during a ten year follow-up of 87 people with varying degrees of glucose intolerance. This reduction was more pronounced for people whose glucose tolerance deteriorated during the follow-up period, and paralleled their increasing HbA1c. In contrast, nerve conduction velocities only decreased from 47.6 to 45.8 m/s, without any significant relation to HbA1c This article is protected by copyright...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29791452/validity-and-reliability-of-two-alternate-versions-of-the-montreal-cognitive-assessment-hong-kong-version-for-screening-of-mild-neurocognitive-disorder
#7
Adrian Wong, Stanley Yiu, Ziad Nasreddine, Kam-Tat Leung, Alexander Lau, Yannie O Y Soo, Lawrence Ka-Sing Wong, Vincent Mok
OBJECTIVE: Repeated testing using the Montreal Cognitive Assessment (MoCA) increases risks for practice effects which may bias measurements of cognitive change. The objective of this study is to develop two alternate versions of the MoCA (Hong Kong version; HK-MoCA) and to investigate the validity and reliability of the alternate versions in patients with DSM-5 Mild Neurocognitive Disorder (Mild NCD) and cognitively healthy controls. METHODS: Concurrent validity and inter-scale agreement were examined by Pearson correlation of the total scores between the original and alternate versions and the Bland-Altman Method...
2018: PloS One
https://www.readbyqxmd.com/read/29790577/esophageal-igg4-levels-correlate-with-histopathologic-and-transcriptomic-features-in-eosinophilic-esophagitis
#8
Chen E Rosenberg, Melissa K Mingler, Julie M Caldwell, Margaret H Collins, Patricia C Fulkerson, David W Morris, Vincent A Mukkada, Philip E Putnam, Tetsuo Shoda, Ting Wen, Marc E Rothenberg
BACKGROUND: Recent data associate eosinophilic esophagitis (EoE) with IgG4 rather than IgE, but its significance and function have not been determined. Our aims were to measure esophageal IgG4 levels and to determine functional correlations as assessed by histologic and transcriptome analyses. METHODS: This case-control study included pediatric subjects with EoE (≥ 15 eosinophils/HPF) and non-EoE controls. Protein lysates were analyzed for IgA, IgM, and IgG1-IgG4 using the Luminex 100 system; IgE was quantified by ELISA...
May 23, 2018: Allergy
https://www.readbyqxmd.com/read/29790292/failure-of-voriconazole-therapy-due-to-acquired-azole-resistance-in-aspergillus-fumigatus-in-a-kidney-transplant-recipient-with-chronic-necrotizing-aspergillosis
#9
Benoit Pilmis, Dea Garcia-Hermoso, Alexandre Alanio, Emilie Catherinot, Anne Scemla, Vincent Jullien, Stéphane Bretagne, Olivier Lortholary
Invasive aspergillosis (IA) affects lungs and disseminates mostly in patients with neutropenia and/or receiving immunosuppressive and steroid therapies. Despite progress in diagnosis and therapy of IA, it is still characterized by a high mortality rate. Currently, voriconazole is considered as the standard therapy for invasive aspergillosis. Over the recent years, triazole resistant Aspergillus fumigatus isolates have emerged in the environment due to the use of fungicidal agricultural products with the risk of developing IA related to a resistant isolate...
May 22, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29790185/a-combined-epicardial-implantation-and-subsequent-extraction-strategy-in-pacemaker-device-infection-in-pacemaker-dependent-patients
#10
Floris S van den Brink, Vincent F van Dijk, Lucas Va Boersma, Maurtis Cef Wijffels, John Gelissen, Edgar Daeter, Uday Sonker, Jippe Balt
INTRODUCTION: Treatment of pacemaker (PM) device infections is challenging in pacemaker dependent patients. We propose a novel implantation strategy for this group of patients. METHODS: Patients who were PM dependent and were admitted with a PM infection received a combined procedure of LV epicardial implantation of a PM lead and subsequent extraction of the infected system. No temporary pacing wire was used and the PM generator was placed in the left flank. RESULTS: Between 2012 and 2015 we treated 16 patients who were PM dependent with a PM infection...
May 23, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29789628/targetable-vulnerabilities-in-t-and-nk-cell-lymphomas-identified-through-preclinical-models
#11
Samuel Y Ng, Noriaki Yoshida, Amanda L Christie, Mahmoud Ghandi, Neekesh V Dharia, Joshua Dempster, Mark Murakami, Kay Shigemori, Sara N Morrow, Alexandria Van Scoyk, Nicolas A Cordero, Kristen E Stevenson, Maneka Puligandla, Brian Haas, Christopher Lo, Robin Meyers, Galen Gao, Andrew Cherniack, Abner Louissaint, Valentina Nardi, Aaron R Thorner, Henry Long, Xintao Qiu, Elizabeth A Morgan, David M Dorfman, Danilo Fiore, Julie Jang, Alan L Epstein, Ahmet Dogan, Yanming Zhang, Steven M Horwitz, Eric D Jacobsen, Solimar Santiago, Jian-Guo Ren, Vincent Guerlavais, D Allen Annis, Manuel Aivado, Mansoor N Saleh, Amitkumar Mehta, Aviad Tsherniak, David Root, Francisca Vazquez, William C Hahn, Giorgio Inghirami, Jon C Aster, David M Weinstock, Raphael Koch
T- and NK-cell lymphomas (TCL) are a heterogenous group of lymphoid malignancies with poor prognosis. In contrast to B-cell and myeloid malignancies, there are few preclinical models of TCLs, which has hampered the development of effective therapeutics. Here we establish and characterize preclinical models of TCL. We identify multiple vulnerabilities that are targetable with currently available agents (e.g., inhibitors of JAK2 or IKZF1) and demonstrate proof-of-principle for biomarker-driven therapies using patient-derived xenografts (PDXs)...
May 22, 2018: Nature Communications
https://www.readbyqxmd.com/read/29789530/efficient-blood-brain-barrier-opening-in-primates-with-neuronavigation-guided-ultrasound-and-real-time-acoustic-mapping
#12
Shih-Ying Wu, Christian Aurup, Carlos Sierra Sanchez, Julien Grondin, Wenlan Zheng, Hermes Kamimura, Vincent P Ferrera, Elisa E Konofagou
Brain diseases including neurological disorders and tumors remain under treated due to the challenge to access the brain, and blood-brain barrier (BBB) restricting drug delivery which, also profoundly limits the development of pharmacological treatment. Focused ultrasound (FUS) with microbubbles is the sole method to open the BBB noninvasively, locally, and transiently and facilitate drug delivery, while translation to the clinic is challenging due to long procedure, targeting limitations, or invasiveness of current systems...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789437/dynamics-of-reca-mediated-repair-of-replication-dependent-dna-breaks
#13
Vincent Amarh, Martin A White, David R F Leach
Chromosomal replication is the major source of spontaneous DNA double-strand breaks (DSBs) in living cells. Repair of these DSBs is essential for cell viability, and accuracy of repair is critical to avoid chromosomal rearrangements. Repair of replication-dependent DSBs occurs primarily by homologous recombination with a sister chromosome. However, this reaction has never been visualized at a defined chromosomal locus, so little is known about its spatial or temporal dynamics. Repair of a replication-independent DSB generated in Escherichia coli by a rare-cutting endonuclease leads to the formation of a bundle of RecA filaments...
May 22, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29789105/oral-anticoagulation-in-chronic-kidney-disease-and-atrial-fibrillation
#14
Gunnar H Heine, Vincent Brandenburg, Stephan H Schirmer
BACKGROUND: Cardiological societies recommend, in their guidelines, that patients with atrial fibrillation and an intermediate (or higher) risk of stroke and systemic embolization should be treated with oral anticoagulant drugs. For patients who do not have mitral valve stenosis or a mechanical valve prosthesis, non-vitamin-K dependent oral anticoagulants (NOAC) are preferred over vitamin K antagonists (VKA) for this purpose. It is unclear, however, whether patients with chronic kidney disease and atrial fibrillation benefit from oral anticoagulation to the same extent as those with normal kidney function...
April 27, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29788434/a-novel-mouse-model-of-testicular-granulosa-cell-tumors
#15
Xin Fang, Nan Ni, Yang Gao, David F Vincent, Laurent Bartholin, Qinglei Li
STUDY QUESTION: What is the role of dysregulated transforming growth factor beta (TGFB) signaling in the development of sex cord-stromal tumors in the testis? SUMMARY ANSWER: Overactivation of TGFB signaling results in the development of testicular tumors resembling granulosa cell tumors (GrCTs). WHAT IS KNOWN ALREADY: In an earlier study, we demonstrated that constitutively active TGFB receptor 1 (TGFBR1) in ovarian somatic cells promotes the development of ovarian GrCTs...
May 21, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29788349/operationalizing-international-regulatory-standards-in-a-limited-resource-setting-during-an-epidemic-the-sierra-leone-trial-to-introduce-a-vaccine-against-ebola-strive-experience
#16
Abdul Karim Kabineh, Wendy Carr, Mahnaz Motevalli, Jennifer Legardy-Williams, Willietta Vincent, Barbara E Mahon, Mohamed Samai
ClinicalTrials.gov [NCT02378753] and Pan African Clinical Trials Registry [PACTR201502001037220].
May 18, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29787992/reliability-and-validity-analysis-of-the-open-source-chinese-foot-and-ankle-outcome-score-faos
#17
Samuel K K Ling, Vincent Chan, Karen Ho, Fona Ling, T H Lui
AIM: Develop the first reliable and validated open-source outcome scoring system in the Chinese language for foot and ankle problems. METHODS: Translation of the English FAOS into Chinese following regular protocols. First, two forward-translations were created separately, these were then combined into a preliminary version by an expert committee, and was subsequently back-translated into English. The process was repeated until the original and back translations were congruent...
December 21, 2017: Foot
https://www.readbyqxmd.com/read/29787940/survey-on-deep-learning-for-radiotherapy
#18
REVIEW
Philippe Meyer, Vincent Noblet, Christophe Mazzara, Alex Lallement
More than 50% of cancer patients are treated with radiotherapy, either exclusively or in combination with other methods. The planning and delivery of radiotherapy treatment is a complex process, but can now be greatly facilitated by artificial intelligence technology. Deep learning is the fastest-growing field in artificial intelligence and has been successfully used in recent years in many domains, including medicine. In this article, we first explain the concept of deep learning, addressing it in the broader context of machine learning...
May 17, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29787675/a-metal-stabilized-quinoidal-dibenzo-g-p-chrysene-fused-bis-dicarbacorrole-system
#19
Xian-Sheng Ke, Yongseok Hong, Vincent M Lynch, Dongho Kim, Jonathan L Sessler
We report here a metal complexation-based strategy that permits access to a highly stable expanded porphyrin-type quinoidal PAH. Specifically, double insertion of Pd(II) ions into a dibenzo[g,p]chrysene-fused bis-dicarbacorrole (bis-H3) gives rise to a bis-metalated species (bis-Pd) that undergoes a facile benzenoid-quinonoid transformation. In contrast to what is true for the corre-sponding mono-Pd(II) complex, which has organic radical character, well resolved 1H- and 19F NMR spectra are seen for bis-Pd. This complex is also electron paramagnetic resonance (EPR) silent over a range of temperatures...
May 22, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29787614/outcome-of-polycystic-kidney-disease-patients-on-peritoneal-dialysis-systematic-review-of-literature-and-meta-analysis
#20
Vincent Dupont, Lukshe Kanagaratnam, Mickaël Sigogne, Clémence Bechade, Thierry Lobbedez, Jose Portoles, Philippe Rieu, Moustapha Drame, Fatouma Touré
BACKGROUND: Polycystic kidney disease (PKD) is the most frequent hereditary cause of chronic kidney disease. Peritoneal dialysis (PD) is often avoided for patients with PKD because of the suspected risk of mechanical and infectious complications. Only a few studies have analyzed the outcome of PKD patients on PD with sometimes conflicting results. The purpose of this meta-analysis was to investigate outcomes of patients with PKD treated by PD. METHODS: A systematic review and meta-analysis were performed examining all studies which included "Polycystic kidney disease" and "Peritoneal dialysis" in their titles, excluding commentaries, letters to the authors and abstracts...
2018: PloS One
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