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https://www.readbyqxmd.com/read/29450447/interplay-among-psychopathologic-variables-personal-resources-context-related-factors-and-real-life-functioning-in-individuals-with-schizophrenia-a-network-analysis
#1
Silvana Galderisi, Paola Rucci, Brian Kirkpatrick, Armida Mucci, Dino Gibertoni, Paola Rocca, Alessandro Rossi, Alessandro Bertolino, Gregory P Strauss, Eugenio Aguglia, Antonello Bellomo, Martino Belvederi Murri, Paola Bucci, Bernardo Carpiniello, Anna Comparelli, Alessandro Cuomo, Domenico De Berardis, Liliana Dell'Osso, Fabio Di Fabio, Barbara Gelao, Carlo Marchesi, Palmiero Monteleone, Cristiana Montemagni, Giulia Orsenigo, Francesca Pacitti, Rita Roncone, Paolo Santonastaso, Alberto Siracusano, Annarita Vignapiano, Antonio Vita, Patrizia Zeppegno, Mario Maj
Importance: Enhanced understanding of factors associated with symptomatic and functional recovery is instrumental to designing personalized treatment plans for people with schizophrenia. To date, this is the first study using network analysis to investigate the associations among cognitive, psychopathologic, and psychosocial variables in a large sample of community-dwelling individuals with schizophrenia. Objective: To assess the interplay among psychopathologic variables, cognitive dysfunctions, functional capacity, personal resources, perceived stigma, and real-life functioning in individuals with schizophrenia, using a data-driven approach...
February 14, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29450213/differential-regulation-of-pai-1-in-hantavirus-cardiopulmonary-syndrome-and-hemorrhagic-fever-with-renal-syndrome
#2
Carla Bellomo, Miša Korva, Anna Papa, Satu Mäkelä, Jukka Mustonen, Tatjana Avšič-Županc, Antti Vaheri, Valeria P Martinez, Tomas Strandin
We analyzed the levels of circulating tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI)-1 in acute hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS). The levels of tPA commonly increased in both diseases, whereas PAI-1 correlated with disease severity in HCPS but not in HFRS.
February 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29435955/effects-of-manual-somatic-stimulation-on-the-autonomic-nervous-system-and-posture
#3
Giovanni Barassi, Rosa Grazia Bellomo, Camillo Di Giulio, Giuseppe Giannuzzo, Giuseppe Irace, Claudia Barbato, Raoul Saggini
Low back pain frequently involves a multifactorial etiology and requires medical attention. The aim of the study was to assess the associations among pain, posture, and autonomic nervous system function in patients with low back pain, using neuromuscular manual therapy versus a generic peripheral manual stimulation (back massage therapy). Twenty young patients with low back pain were enrolled into the study. The patients were randomly divided into two groups: treated with neuromuscular manual therapy performed after a specific structural evaluation and treated with back massage therapy...
February 13, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29428606/influence-of-ward-round-order-on-critically-ill-patient-outcomes
#4
Steve Evans, Jai Darvall, Alexandra Gorelik, Rinaldo Bellomo
PURPOSE: To examine the effect of order in which patients are seen on an Intensive Care Unit (ICU) ward round on ICU length of stay (LOS), mortality and duration of mechanical ventilation. MATERIALS AND METHODS: Retrospective observational study in a tertiary metropolitan ICU over a 12month period. All patients who occupied the first and last three bed spaces of the ICU ward round, without having moved bed spaces during admission, were included. Separate analyses were performed for the absolute first and last patients...
February 3, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29413729/characteristics-incidence-and-outcome-of-patients-admitted-to-the-intensive-care-unit-with-myasthenia-gravis
#5
Wisam Al-Bassam, Mark Kubicki, Michael Bailey, Laurence Walker, Paul Young, David V Pilcher, Rinaldo Bellomo
BACKGROUND: There are limited data on the characteristics, incidence, and mortality of patients with myasthenia gravis (MG) admitted to the ICU. AIMS: To study the epidemiology, characteristics and outcome of patients with MG in Australian and New Zealand (ANZ) ICUs over a decade. METHODS: We performed a retrospective observational, cross sectional study of data from the Australian and New Zealand Intensive Care Society (ANZICS) Adult Patient Database (APD)...
January 7, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29413724/characteristics-incidence-and-outcome-of-patients-admitted-to-intensive-care-unit-with-guillain-barre-syndrome-in-australia-and-new-zealand
#6
Paolo Ancona, Michael Bailey, Rinaldo Bellomo
PURPOSE: To describe characteristics, incidence and outcome of patients with Guillain-Barre syndrome (GBS) admitted to ICU. METHODS: We conducted a binational, retrospective, observational, epidemiological study. We compared the baseline characteristics, physiological conditions and outcomes for GBS patients with or without mechanical ventilation (MV) and of survivors and non-survivors. RESULTS: We studied 711 patients admitted to 173 ICUs between 2005 and 2015...
January 29, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29402750/a-bridge-towards-a-mathematical-theory-of-living-systems-comment-on-physics-of-mind-experimental-confirmations-of-theoretical-predictions-by-f-schoeller-l-perlovsky-and-d-arseniev
#7
https://www.readbyqxmd.com/read/29397903/lymph-node-macrophages-scavengers-immune-sentinels-and-trophic-effectors
#8
REVIEW
Alicia Bellomo, Rebecca Gentek, Marc Bajénoff, Myriam Baratin
Lymph nodes (LN) are secondary lymphoid organs dispersed throughout the body that filter lymph and assist the immune system in mounting immune responses. These functions are supported by a complex stromal microarchitecture composed of mesenchymal and vascular elements. Different subsets of macrophages (MΦ) reside in the LN and are endowed with immune and trophic functions. Here we review these different subsets with particular emphasis on the recently described T cell zone MΦ. We also address the potential crosstalk between LN stromal cells and MΦ, proposing that the former constitute niches for the latter by supplying factors required for their specification, survival and turnover...
February 1, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29393097/uric-acid-the-lower-the-better
#9
Gianni Bellomo, Antonio Selvi
BACKGROUND: Uric acid (UA) is still considered a risk factor, or even a causative agent, for chronic kidney disease (CKD); however, a few, important, clinical questions remain unanswered; in particular: when and whether urate-lowering therapy should be commenced in subjects with asymptomatic hyperuricemia and/or monosodium urate crystals deposition? What is the most appropriate UA target to be achieved and how long does it need to be maintained? How does treatment need be adjusted in patients with chronic kidney disease? SUMMARY: The observational and intervention studies available do not fully answer such questions, and a treatment to target trial is required...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29390267/rehabilitation-program-based-on-sensorimotor-recovery-improves-the-static-and-dynamic-balance-and-modifies-the-basal-ganglia-neurochemistry-a-pilot-1h-mrs-study-on-parkinson-s-disease-patients
#10
Stefano Delli Pizzi, Rosa Grazia Bellomo, Simona Maria Carmignano, Emilio Ancona, Raffaella Franciotti, Marco Supplizi, Giovanni Barassi, Marco Onofrj, Laura Bonanni, Raoul Saggini
Rehabilitation interventions represent an alternative strategy to pharmacological treatment in order to slow or reverse some functional aspects of disability in Parkinson's disease (PD). To date, the neurophysiological mechanisms underlying rehabilitation-mediated improvement in PD patients are still poorly understood. Interestingly, growing evidence has highlighted a key role of the glutamate in neurogenesis and brain plasticity. The brain levels of glutamate, and of its precursor glutamine, can be detected in vivo and noninvasively as "Glx" by means of proton magnetic resonance spectroscopy (H-MRS)...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29382510/preoperative-renal-functional-reserve-predicts-risk-of-acute-kidney-injury-after-cardiac-surgery
#11
Faeq Husain-Syed, Fiorenza Ferrari, Aashish Sharma, Tommaso Hinna Danesi, Pércia Bezerra, Salvador Lopez-Giacoman, Sara Samoni, Massimo de Cal, Valentina Corradi, Grazia Maria Virzì, Silvia De Rosa, María Jimena Muciño Bermejo, Carla Estremadoyro, Gianluca Villa, Jose J Zaragoza, Carlotta Caprara, Alessandra Brocca, Horst-Walter Birk, Hans-Dieter Walmrath, Werner Seeger, Federico Nalesso, Monica Zanella, Alessandra Brendolan, Davide Giavarina, Loris Salvador, Rinaldo Bellomo, Mitchell H Rosner, John A Kellum, Claudio Ronco
BACKGROUND: Although acute kidney injury (AKI) frequently complicates cardiac surgery, methods to determine AKI risk in patients without underlying kidney disease are lacking. Renal functional reserve (RFR) can be used to measure the capacity of the kidney to increase glomerular filtration rate under conditions of physiological stress and may serve as a functional marker that assesses susceptibility to injury. We sought to determine whether preoperative RFR predicts postoperative AKI...
January 27, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29366580/urinary-biomarkers-may-provide-prognostic-information-for-subclinical-acute-kidney-injury-after-cardiac-surgery
#12
Christian Albert, Annemarie Albert, Johanna Kube, Rinaldo Bellomo, Nicholas Wettersten, Hermann Kuppe, Sabine Westphal, Michael Haase, Anja Haase-Fielitz
OBJECTIVE: This study aimed to determine the biomarker-specific outcome patterns and short-and long-term prognosis of cardiac surgery-asoociated acute kidney injury (AKI) identified by standard criteria and/or urinary kidney biomarkers. METHODS: Patients enrolled (N = 200), originated a German multicenter study (NCT00672334). Standard risk injury, failure, loss, and end-stage renal disease classification (RIFLE) criteria (including serum creatinine and urine output) and urinary kidney biomarker test result (neutrophil gelatinase-associated lipocalin, midkine, interleukin 6, and proteinuria) were used for diagnosis of postoperative AKI...
December 22, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29361264/fluid-bolus-therapy-for-the-ward-treatment-of-oliguria-after-major-abdominal-surgery
#13
M A Kubicki, G M Eastwood, R Bellomo
No abstract text is available yet for this article.
January 2018: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/29361260/associations-of-fluid-amount-type-and-balance-and-acute-kidney-injury-in-patients-undergoing-major-surgery
#14
L Weinberg, Mhg Li, L Churilov, A Armellini, M Gibney, T Hewitt, C O Tan, R Robbins, D Tremewen, C Christophi, R Bellomo
Fluid administration has been reported to be associated with an increased risk of acute kidney injury (AKI). We assessed whether, after correction for fluid balance, amount and chloride content of fluids administered have an independent association with AKI. We performed an observational study in patients after major surgery assessing the independent association of AKI with volume, chloride content and fluid balance, after adjustment for Physiological and Operative Severity Score for enUmeration of Mortality and morbidity (POSSUM) score, age, elective versus emergency surgery, and duration of surgery...
January 2018: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/29355684/impact-of-adenosine-a2a-receptor-polymorphism-rs5751876-on-platelet-reactivity-in-ticagrelor-treated-patients
#15
Matteo Nardin, Monica Verdoia, Patrizia Pergolini, Roberta Rolla, Lucia Barbieri, Paolo Marino, Giorgio Bellomo, Elvin Kedhi, Harry Suryapranata, Alessandro Carriero, Giuseppe De Luca
Dual antiplatelet therapy constitutes a key point in the management of patients with acute coronary syndromes. In particular, ticagrelor, an ADP-antagonist, can provide a more potent and predictable platelet inhibition as compared to clopidogrel, and adenosine-mediated pathways have been involved in its beneficial effects on mortality and myocardial perfusion. However, a quote of patients still displays a suboptimal platelet inhibition on ticagrelor, and, while the role of genetics in conditioning clopidogrel resistance is well established, few data have been reported for ticagrelor...
January 17, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29354158/effect-of-combined-treatment-with-focused-mechano-acoustic-vibration-and-pharmacological-therapy-on-bone-mineral-density-and-muscle-strength-in-post-menopausal-women
#16
Raoul Saggini, Emilio Ancona, Simona Maria Carmignano, Marco Supplizi, Giovanni Barassi, Rosa Grazia Bellomo
Introduction: Osteoporosis is a systemic disease of the skeleton characterized by a reduction in bone mass and alterations in microarchitecture accompanied by increase in fracture risk, with a relevant decline in quality of life and important social, economic, and health implications, representing one of the most common causes of disability and a major financial item of health cost in many Countries. The best therapy for osteoporosis is prevention, consisting in measures to avoid or slow the onset of the disease...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29353118/magnesium-supplementation-pharmacokinetics-in-cardiac-surgery-patients-with-normal-renal-function
#17
Peter Biesenbach, Johan Mårtensson, Eduardo Osawa, Glenn Eastwood, Salvatore Cutuli, Jessica Fairley, George Matalanis, Rinaldo Bellomo
BACKGROUND: Intravenous magnesium is routinely administered in intensive care units (ICU) to treat arrhythmias after cardiothoracic surgery. There are no data on the pharmacokinetics of continuous magnesium infusion therapy. OBJECTIVE: To investigate the pharmacokinetics of continuous magnesium infusion, focusing on serum and urinary magnesium concentration, volume of distribution and half-life. METHODS: We administered a 10 mmol bolus of magnesium-sulfate followed by a continuous infusion of 3 mmol/h for 12 h in twenty cardiac surgery patients...
January 11, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29351759/tracheal-intubation-in-critically-ill-patients-a-comprehensive-systematic-review-of-randomized-trials
#18
Luca Cabrini, Giovanni Landoni, Martina Baiardo Radaelli, Omar Saleh, Carmine D Votta, Evgeny Fominskiy, Alessandro Putzu, Cézar Daniel Snak de Souza, Massimo Antonelli, Rinaldo Bellomo, Paolo Pelosi, Alberto Zangrillo
BACKGROUND: We performed a systematic review of randomized controlled studies evaluating any drug, technique or device aimed at improving the success rate or safety of tracheal intubation in the critically ill. METHODS: We searched PubMed, BioMed Central, Embase and the Cochrane Central Register of Clinical Trials and references of retrieved articles. Finally, pertinent reviews were also scanned to detect further studies until May 2017. The following inclusion criteria were considered: tracheal intubation in adult critically ill patients; randomized controlled trial; study performed in Intensive Care Unit, Emergency Department or ordinary ward; and work published in the last 20 years...
January 20, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29347874/adjunctive-glucocorticoid-therapy-in-patients-with-septic-shock
#19
Balasubramanian Venkatesh, Simon Finfer, Jeremy Cohen, Dorrilyn Rajbhandari, Yaseen Arabi, Rinaldo Bellomo, Laurent Billot, Maryam Correa, Parisa Glass, Meg Harward, Christopher Joyce, Qiang Li, Colin McArthur, Anders Perner, Andrew Rhodes, Kelly Thompson, Steve Webb, John Myburgh
Background Whether hydrocortisone reduces mortality among patients with septic shock is unclear. Methods We randomly assigned patients with septic shock who were undergoing mechanical ventilation to receive hydrocortisone (at a dose of 200 mg per day) or placebo for 7 days or until death or discharge from the intensive care unit (ICU), whichever came first. The primary outcome was death from any cause at 90 days. Results From March 2013 through April 2017, a total of 3800 patients underwent randomization. Status with respect to the primary outcome was ascertained in 3658 patients (1832 of whom had been assigned to the hydrocortisone group and 1826 to the placebo group)...
January 19, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29341498/review-article-sepsis-in-the-emergency-department-part-2-investigations-and-monitoring
#20
REVIEW
Amith Shetty, Stephen Pj Macdonald, Gerben Keijzers, Julian M Williams, Benjamin Tang, Bas de Groot, Kelly Thompson, John F Fraser, Simon Finfer, Rinaldo Bellomo, Jonathan Iredell
Sepsis is characterised by organ dysfunction resulting from infection, with no reliable single objective test and current diagnosis based on clinical features and results of investigations. In the ED, investigations may be conducted to diagnose infection as the cause of the presenting illness, identify the source, distinguish sepsis from uncomplicated infection (i.e. without organ dysfunction) and/ or risk stratification. Appropriate sample collection for microbiological testing remains key for subsequent confirmation of diagnosis and rationalisation of antimicrobials...
February 2018: Emergency Medicine Australasia: EMA
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