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https://www.readbyqxmd.com/read/29663047/are-systematic-reviews-and-meta-analyses-still-useful-research-no
#1
EDITORIAL
Sylvie Chevret, Niall D Ferguson, Rinaldo Bellomo
No abstract text is available yet for this article.
April 16, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29660669/the-systemic-inflammatory-response-syndrome-criteria-and-their-differential-association-with-mortality
#2
Kirsi-Maija Kaukonen, Michael Bailey, David Pilcher, D James Cooper, Rinaldo Bellomo
PURPOSE: Despite the recent Sepsis-3 consensus, the Systemic Inflammatory Response Syndrome (SIRS) criteria continue to be assessed and recommended. Such use implies equivalence and interchangeability of criteria. Thus, we aimed to test whether such criteria are indeed equivalent and interchangeable. MATERIALS AND METHODS: From 2000 to 2015, we identified patients with infection, organ failure, and at least one SIRS criterion in 179 Intensive Care Units in Australia and New...
April 7, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29659631/the-hemodynamic-effects-of-intravenous-paracetamol-acetaminophen-vs-normal-saline-in-cardiac-surgery-patients-a-single-center-placebo-controlled-randomized-study
#3
Elizabeth Chiam, Rinaldo Bellomo, Leonid Churilov, Laurence Weinberg
The hemodynamic effects of intravenous (IV) paracetamol in patients undergoing cardiac surgery are unknown. We performed a prospective single center placebo controlled randomized study with parallel group design in adult patients undergoing elective cardiac surgery. Participants received paracetamol (1 gram) IV or placebo (an equal volume of 0.9% saline) preoperatively followed by two postoperative doses 6 hours apart. The primary endpoint was the absolute change in systolic (SBP) 30 minutes after the preoperative infusion, analysed using an ANCOVA model...
2018: PloS One
https://www.readbyqxmd.com/read/29659294/palladium-catalyzed-direct-c-h-arylation-of-3-methylsulfinyl-thiophenes
#4
Hui Jiang, Ana Bellomo, Mengnan Zhang, Patrick J Carroll, Brian C Manor, Tiezheng Jia, Patrick J Walsh
A palladium-catalyzed direct arylation of (3-thiophene)S(O)Me derivatives has been developed. This protocol is effective for the selective synthesis of 2-arylated and 2,5-diarylated sulfinylthiophene derivatives with as low as 0.5 mol % catalyst loading. Various functional groups are well tolerated. A method to install two different aryl groups on 3-(methylsulfinyl)thiophenes is also introduced.
April 16, 2018: Organic Letters
https://www.readbyqxmd.com/read/29616481/preoperative-rehabilitation-in-lung-cancer-patients-yoga-approach
#5
Giovanni Barassi, Rosa Grazia Bellomo, Antonella Di Iulio, Achille Lococo, Annamaria Porreca, Piera Attilia Di Felice, Raoul Saggini
Lung cancer is one of the leading causes of cancer death worldwide. Surgical removal remains the best option for most tumors of this type. Reduction of cigarette consumption in patients with lung cancer candidates for the surgery could limit the impact of tobacco on postsurgical outcomes. Breathing exercises appear to help combat cigarette cravings. Yoga exercise benefits have been studied in lung cancer survivors, rather than in the preoperative setting. In this study, we have recruited 32 active smokers affected by lung cancer and being candidates for pulmonary surgery...
April 4, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29613975/antibiotic-overuse-in-premature-low-birth-weight-infants-in-a-developing-country
#6
Maria S Rueda, Renzo Calderon-Anyosa, Jorge Gonzales, Christie G Turin, Alonso Zea-Vera, Jaime Zegarra, Sicilia Bellomo, Luis Cam, Anne Castaneda, Theresa J Ochoa
BACKGROUND: Neonatal sepsis is a leading cause of child morbidity and mortality, especially in premature and low-birth-weight (LBW) infants. Prompt antibiotic therapy is warranted, but its inappropriate use leads to bacterial resistance and adverse outcomes. Our objective is to describe the antibiotic use for late onset sepsis (LOS) in Peruvian premature infants. METHODS: Prospective study as a secondary analysis of a clinical trial in three Neonatal Care Units in Peru...
April 2, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29601005/resource-theoretic-approach-to-vectorial-coherence
#7
G M Bosyk, G Bellomo, A Luis
We propose a formal resource-theoretic approach to assess the coherence between partially polarized electromagnetic fields. From this framework, we identify two resource theories for the vectorial coherence: polarization-sensitive coherence and polarization-insensitive coherence. For each theory, we find the set of incoherent states and a class of operations that preserve this set (i.e., the incoherent operations). Both resource theories are endowed with a certain preorder relation that provides a hierarchy among the coherence-polarization states; thus, a necessary condition to consider in deciding whether a quantity is proper to measure the vectorial coherence is that it respects such a hierarchy...
April 1, 2018: Optics Letters
https://www.readbyqxmd.com/read/29597220/extra-renal-indications-for-continuous-renal-replacement-therapy
#8
Suvi T Vaara, Rinaldo Bellomo
Continuous renal replacement therapy (CRRT) has many potential indications that extend beyond the traditional removal of uremic waste products. Many of these stem from the capacity of CRRT to remove middle-sized molecules and its suitability for haemodynamically unstable patients. Using CRRT for immunomodulation to remove circulating plasma cytokines has created great enthusiasm and, in the past, immunomodulation was a frequently reported indication for commencing CRRT. Unfortunately, recent evidence from randomized controlled trials has been discouraging, and CRRT cannot be recommended for immunomodulation...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29581095/the-presence-of-diabetes-and-higher-hba-1c-are-independently-associated-with-adverse-outcomes-after-surgery
#9
Priscilla H Yong, Laurence Weinberg, Niloufar Torkamani, Leonid Churilov, Raymond J Robbins, Ronald Ma, Rinaldo Bellomo, Que T Lam, James D Burns, Graeme K Hart, Jeremy F Lew, Johan Mårtensson, David Story, Andrew N Motley, Douglas Johnson, Jeffrey D Zajac, Elif I Ekinci
OBJECTIVE: Limited studies have examined the association between diabetes and HbA1c with postoperative outcomes. We investigated the association of diabetes, defined categorically and HbA1c as a continuous measure, with postoperative outcomes. RESEARCH DESIGN AND METHODS: In this prospective, observational study, we measured the HbA1c of surgical inpatients age ≥54 years at a tertiary hospital between May 2013 and January 2016. Patients were diagnosed with diabetes if they had preexisting diabetes or an HbA1c ≥6...
March 26, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29562543/different-cognitive-frailty-models-and-health-and-cognitive-related-outcomes-in-older-age-from-epidemiology-to-prevention
#10
Francesco Panza, Madia Lozupone, Vincenzo Solfrizzi, Rodolfo Sardone, Vittorio Dibello, Luca Di Lena, Francesca D'Urso, Roberta Stallone, Massimo Petruzzi, Gianluigi Giannelli, Nicola Quaranta, Antonello Bellomo, Antonio Greco, Antonio Daniele, Davide Seripa, Giancarlo Logroscino
Frailty, a critical intermediate status of the aging process that is at increased risk for negative health-related events, includes physical, cognitive, and psychosocial domains or phenotypes. Cognitive frailty is a condition recently defined by operationalized criteria describing coexisting physical frailty and mild cognitive impairment (MCI), with two proposed subtypes: potentially reversible cognitive frailty (physical frailty/MCI) and reversible cognitive frailty (physical frailty/pre-MCI subjective cognitive decline)...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29550536/salivary-alpha-amylase-and-cortisol-responsiveness-to-stress-in-first-episode-drug-na%C3%A3-ve-patients-with-panic-disorder
#11
Mario Altamura, Salvatore Iuso, Angela Balzotti, Girolamo Francavilla, Andrea Dimitri, Giuseppe Cibelli, Antonello Bellomo, Annamaria Petito
Reported findings on reactivity to stress of the sympathetic-adreno-medullar (SAM) and hypothalamic-pituitary-adrenal (HPA) systems in panic disorder (PD) are very variable. This inconsistency may be explained by differences in treatment exposure, illness duration and emotion regulation strategies. The present study examined the reactivity to mental stress of the SAM and HPA axes in a sample of first episode, drug naïve patients with PD which avoids confounds of medications exposure and illness chronicity...
March 14, 2018: Neuroscience Research
https://www.readbyqxmd.com/read/29549422/impact-of-atypical-mitochondrial-cyclic-amp-level-in-nephropathic-cystinosis
#12
Francesco Bellomo, Anna Signorile, Grazia Tamma, Marianna Ranieri, Francesco Emma, Domenico De Rasmo
Nephropathic cystinosis (NC) is a rare disease caused by mutations in the CTNS gene encoding for cystinosin, a lysosomal transmembrane cystine/H+ symporter, which promotes the efflux of cystine from lysosomes to cytosol. NC is the most frequent cause of Fanconi syndrome (FS) in young children, the molecular basis of which is not well established. Proximal tubular cells have very high metabolic rate due to the active transport of many solutes. Not surprisingly, mitochondrial disorders are often characterized by FS...
March 16, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29544405/the-effect-of-protamine-dosing-variation-on-bleeding-and-transfusion-after-heparinisation-for-cardiopulmonary-bypass
#13
Stephen A Kunz, Lachlan F Miles, Damian J Ianno, Kelly L Mirowska-Allen, George Matalanis, Rinaldo Bellomo, Siven Seevanayagam
INTRODUCTION: Accurate dosing of protamine reversal following on-pump cardiac surgical procedures is challenging, with both excessive and inadequate administration recognised to increase bleeding risk. We aimed to examine the relationship between three ratios for heparin reversal and markers of haemostasis. METHODS: A retrospective analysis of a prospectively collected database was undertaken at a single tertiary cardiac unit, reviewing all cases of on-pump coronary artery bypass grafts and single valve replacements from 01/01/2011 to 31/12/2015...
March 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29544173/early-glycemia-and-mortality-in-critically-ill-septic-patients-interaction-with-insulin-treated-diabetes
#14
Fraser Magee, Michael Bailey, David V Pilcher, Johan Mårtensson, Rinaldo Bellomo
PURPOSE: To investigate the relationship between dysglycemia and hospital mortality in patients with and without a preadmission diagnosis of insulin treated diabetes mellitus (ITDM). MATERIALS AND METHODS: An observational multicentre cohort study using the ANZICS-APD database on adult patients admitted to ICU with sepsis between January 1st 2006 and December 31st 2015. Four domains of dysglycemia were investigated (highest, mean and lowest blood glucose levels and glycemic variability: the absolute difference between the highest and lowest level)...
March 3, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29534079/administrative-data-underestimate-acute-ischemic-stroke-events-and-thrombolysis-treatments-data-from-a-multicenter-validation-survey-in-italy
#15
Marzia Baldereschi, Daniela Balzi, Valeria Di Fabrizio, Lucia De Vito, Renzo Ricci, Paola D'Onofrio, Antonio Di Carlo, Maria Teresa Mechi, Francesco Bellomo, Domenico Inzitari
BACKGROUND: Informing health systems and monitoring hospital performances using administrative data sets, mainly hospital discharge data coded according to International-Classification-Diseases-9edition-Clinical-Modifiers (ICD9-CM), is now commonplace in several countries, but the reliability of diagnostic coding of acute ischemic stroke in the routine practice is uncertain. This study aimed at estimating accuracy of ICD9-CM codes for the identification of acute ischemic stroke and the use of thrombolysis treatment comparing hospital discharge data with medical record review in all the six hospitals of the Florence Area, Italy, through 2015...
2018: PloS One
https://www.readbyqxmd.com/read/29532649/contralateral-effect-of-short-duration-unilateral-neuromuscular-electrical-stimulation-and-focal-vibration-in-healthy-subjects
#16
Marco A Minetto, Alberto Botter, Giulia Gamerro, Ilaria Varvello, Giuseppe Massazza, Rosa G Bellomo, Nicola A Maffiuletti, Raoul Saggini
BACKGROUND: The "contralateral effect" phenomenon refers to the strength gain in the opposite, untrained homonymous muscle following unilateral training. Previous studies showed that neuromuscular electrical stimulation (NMES) of the right quadriceps facilitated maximal voluntary strength and efferent neural drive of the left knee extensors, while no previous study investigated the contralateral effect elicited by focal muscle vibration. AIM: To investigate whether quadriceps NMES and focal vibration, when applied unilaterally, have the same potential to enhance the contralateral muscle strength and the associated neural drive...
March 12, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29527319/inferior-heel-pain-in-soccer-players-a-retrospective-study-with-a-proposal-for-guidelines-of-treatment
#17
Raoul Saggini, Maurizio Migliorini, Simona Maria Carmignano, Emilio Ancona, Chiara Russo, Rosa Grazia Bellomo
Background: The cause of heel pain among soccer players is multifactorial and is related to repetitive microtrauma due to impact forces involving technical moves, but also the playground, the exercise mode, the recovery time, the climatic conditions and the footwear used. Aim: To investigate the aetiology of plantar heel pain of soccer players with the objective of proposing an example of guidelines for treatment. Methods: We investigated the prevalence and characteristics of inferior heel pain of 1473 professional, semiprofessional and amateur players...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29515846/on-the-feasibility-of-the-computational-modelling-of-the-endoluminal-vacuum-assisted-closure-of-an-oesophageal-anastomotic-leakage
#18
Ester Comellas, Facundo J Bellomo, Iván Rosales, Luis F Del Castillo, Ricardo Sánchez, Pau Turon, Sergio Oller
Endoluminal vacuum-assisted closure (E-VAC) is a promising therapy to treat anastomotic leakages of the oesophagus and bowel which are associated with high morbidity and mortality rates. An open-pore polyurethane foam is introduced into the leakage cavity and connected to a device that applies a suction pressure to accelerate the closure of the defect. Computational analysis of this healing process can advance our understanding of the biomechanical mechanisms at play. To this aim, we use a dual-stage finite-element analysis in which (i) the structural problem addresses the cavity reduction caused by the suction and (ii) a new constitutive formulation models tissue healing via permanent deformations coupled to a stiffness increase...
February 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29514518/responsiveness-of-noninvasive-continuous-cardiac-output-monitoring-during-the-valsalva-maneuver
#19
L J Delaney, R Bellomo, F van Haren
To describe the baseline hemodynamic variables and response time of hemodynamic changes associated with the Valsalva maneuver using noninvasive continuous cardiac output monitoring (Nexfin). Hemodynamic monitoring provides an integral component of advanced clinical care and the ability to monitor response to treatment interventions. The emergence of noninvasive hemodynamic monitoring provides clinicians with an opportunity to monitor and assess patients rapidly with ease of implementation. However, the responsiveness of this method in tracking dynamic changes that occur has not been fully elucidated...
March 1, 2018: Clinical Nursing Research
https://www.readbyqxmd.com/read/29512390/role-of-zinc-and-magnesium-ions-in-the-modulation-of-phosphoryl-transfer-in-protein-tyrosine-phosphatase-1b
#20
Elisa Bellomo, Asma Abro, Christer Hogstrand, Wolfgang Maret, Carmen Domene
Whilst the majority of phosphatases are metalloenzymes, the prevailing model for the reactions catalyzed by protein tyrosine phosphatases does not involve any metal ion. Yet, both metal cations and oxoanions affect their enzymatic activity. Mg2+ and Zn2+ activate and inhibit, respectively, protein tyrosine phosphatase 1B (PTP1B). Molecular dynamics simulations, metadynamics and quantum chemical calculations in combination with experimental investigations demonstrate that Mg2+ and Zn2+ compete for the same binding site in the active site only in the closed conformation of the enzyme in its phosphorylated state...
March 7, 2018: Journal of the American Chemical Society
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