Leeran Talker, Cihan Dogan, Daniel Neville, Rui Hen Lim, Henry Broomfield, Gabriel Lambert, Ahmed Selim, Thomas Brown, Laura Wiffen, Julian Carter, Helen F Ashdown, Gail Hayward, Elango Vijaykumar, Scott T Weiss, Anoop Chauhan, Ameera X Patel
INTRODUCTION: Spirometry is the gold standard for COPD diagnosis and severity determination, but is technique-dependent, nonspecific, and requires administration by a trained healthcare professional. There is a need for a fast, reliable, and precise alternative diagnostic test. This study's aim was to use interpretable machine learning to diagnose COPD and assess severity using 75-second carbon dioxide (CO2 ) breath records captured with TidalSense's N-TidalTM capnometer. METHOD: For COPD diagnosis, machine learning algorithms were trained and evaluated on 294 COPD (including GOLD stages 1-4) and 705 non-COPD participants...
December 2024: COPD