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https://www.readbyqxmd.com/read/29041000/genetic-variations-of-oxidative-stress-related-genes-alox5-alox5ap-and-mpo-modulate-ischemic-stroke-susceptibility-through-main-effects-and-epistatic-interactions-in-a-chinese-population
#1
Ding Liu, Lei Liu, Zhi Song, Zhongyang Hu, Jia Liu, Deren Hou
BACKGROUND/AIMS: To investigate the roles of the oxidative stress related-genes ALOX5, ALOX5AP and MPO in ischemic stroke susceptibility in the Han Chinese population. METHODS: A total of 351 ischemic stroke patients and 417 controls were recruited. The ALOX5 rs10900213, ALOX5AP rs4293222 and MPO rs2107545 gene polymorphisms were genotyped. RESULTS: We identified that rs2107545 of MPO gene was significantly associated with ischemic stroke susceptibility after adjusting for covariates...
October 17, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29040991/impact-of-tumor-factors-on-survival-in-patients-with-hepatocellular-carcinoma-classified-based-on-kinki-criteria-stage-b2
#2
Tadaaki Arizumi, Tomohiro Minami, Hirokazu Chishina, Masashi Kono, Masahiro Takita, Norihisa Yada, Satoru Hagiwara, Yasunori Minami, Hiroshi Ida, Kazuomi Ueshima, Ken Kamata, Kosuke Minaga, Yoriaki Komeda, Mamoru Takenaka, Toshiharu Sakurai, Tomohiro Watanabe, Naoshi Nishida, Masatoshi Kudo
BACKGROUND: Tumors classified based on the Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC) are heterogeneous in nature. Previously, the Kinki criterion was proposed for a more precise subclassification of tumors in BCLC-stage B. However, tumors in sub-stage B2 include various size and number of HCCs even with the Kinki criteria, which could lead to heterogeneity for overall survival (OS). In this study, we assessed how the size and number of tumors affect the OS and time to progression (TTP) in patients with Kinki criteria stage B2 tumors and treated with transarterial chemoembolization (TACE)...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040987/hepatocarcinogenesis-is-associated-with-serum-albumin-levels-after-sustained-virological-responses-with-interferon-based-therapy-in-patients-with-hepatitis-c
#3
Yasuko Umehara, Satoru Hagiwara, Naoshi Nishida, Toshiharu Sakurai, Hiroshi Ida, Yasunori Minami, Masahiro Takita, Tomohiro Minami, Hirokazu Chishina, Kazuomi Ueshima, Yoriaki Komeda, Tadaaki Arizumi, Tomohiro Watanabe, Masatoshi Kudo
OBJECTIVE: It is a generally accepted fact that eradication of hepatitis virus C inhibits the subsequent development of hepatocellular carcinoma (HCC). On the contrary, a significant population of patients developed HCC despite sustained virological responses (SVRs) to interferon (IFN) therapy. METHODS: A total of 415 patients with chronic hepatitis C, who were treated at our hospital between 2004 and 2014, were enrolled for this study. We examined the risk factors for HCC development after IFN therapy...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040985/serum-ifn-%C3%AE-3-levels-correlate-with-serum-hepatitis-c-virus-rna-levels-in-symptomatic-patients-with-acute-hepatitis-c
#4
Susumu Imoto, Soo Ryang Kim, Keisuke Amano, Etsuko Iio, Seitetsu Yoon, Shigeya Hirohata, Yoshihiko Yano, Toru Ishikawa, Shinji Katsushima, Toshiki Komeda, Toyokazu Fukunaga, Hobyung Chung, Hiroyuki Kokuryu, Yutaka Horie, Takashi Hatae, Aya Fujinami, Soo Ki Kim, Masatoshi Kudo, Yasuhito Tanaka
BACKGROUND: Recent genome-wide association studies demonstrated that 2 single nucleotide polymorphisms (SNPs), upstream of the interferon-λ (IFNL) 3 gene, are associated with the spontaneous clearance of hepatitis C virus (HCV) in symptomatic patients with acute hepatitis C (AHC). Although these 2 SNPs, rs8099917 and rs12979860, have established their significant roles in the innate immunity response to spontaneously clear HCV in patients with AHC, the detailed mechanisms of their roles remain largely unknown...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040971/characteristics-and-outcomes-of-vertebrobasilar-artery-dissection-with-accompanied-atherosclerosis
#5
Chun Chien, Feng-Chi Chang, Hui-Chi Huang, Jui-Yao Tsai, Chih-Ping Chung
BACKGROUND: With the popularity of MRI use, vertebrobasilar artery dissection (VBD) has been found more frequently in patients with posterior circulation ischemic stroke (PCS). The relationship between VBD and atherosclerosis is unknown. The present study aimed to prove the hypothesis that PCS with pure VBD (p-VBD) and with VBD and accompanied cervical or cerebral artery atherosclerosis (a-VBD) have distinct manifestations. METHODS: Patients with VBD-related PCS who were prospectively enrolled in the Taipei Veterans General Hospital Stroke Registry between January 1, 2010 and August 31, 2014 were recruited for the present study...
October 17, 2017: Cerebrovascular Diseases Extra
https://www.readbyqxmd.com/read/29040951/perfluoroalkyl-substances-bone-density-and-cardio-metabolic-risk-factors-in-obese-8-12-year-old-children-a-pilot-study
#6
Naila Khalil, James R Ebert, Masato Honda, Miryoung Lee, Ramzi W Nahhas, Antti Koskela, Thomas Hangartner, Kurunthachalam Kannan
BACKGROUND AND OBJECTIVE: Perfluoroalkyl substances (PFASs), including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA), have been associated with adverse bone, and metabolic changes in adults. However association of PFASs with bone health in children is understudied. Considering their role as endocrine disruptors, we examined relationships of four PFASs with bone health in children. METHODS: In a cross sectional pilot study, 48 obese children aged 8-12 years were enrolled from Dayton's Children Hospital, Ohio...
October 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/29040884/heart-rate-variability-feature-selection-in-the-presence-of-sleep-apnea-an-expert-system-for-the-characterization-and-detection-of-the-disorder
#7
Sofía Martín-González, Juan L Navarro-Mesa, Gabriel Juliá-Serdá, Jan F Kraemer, Niels Wessel, Antonio G Ravelo-García
We introduce a sleep apnea characterization and classification approach based on a Heart Rate Variability (HRV) feature selection process, thus focusing on the characterization of the underlying process from a cardiac rate point of view. Therefore, we introduce linear and nonlinear variables, namely Cepstrum Coefficients (CC), Filterbanks (Fbank) and Detrended Fluctuation Analysis (DFA). Logistic Regression, Linear Discriminant Analysis and Quadratic Discriminant Analysis were used for classification purposes...
October 7, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29040883/veno-arterial-extracorporeal-membrane-oxygenation-va-ecmo-for-emergency-cardiac-support
#8
Terri Sun, Andrew Guy, Amandeep Sidhu, Gordon Finlayson, Brian Grunau, Lillian Ding, Saida Harle, Leith Dewar, Richard Cook, Hussein D Kanji
PURPOSE: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) may provide benefit to patients in refractory cardiac arrest and cardiogenic shock. We aim to summarize our center's 6-year experience with resuscitative VA-ECMO. MATERIALS AND METHODS: A retrospective medical record review (April 2009 to 2015) was performed on consecutive non-cardiotomy patients who were managed with VA-ECMO due to refractory in- or out-of-hospital cardiac (IHCA/OHCA) arrest (E-CPR) or refractory cardiogenic shock (E-CS) with or without preceding cardiac arrest...
October 12, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29040821/dietary-intake-and-omega-3-dha-status-in-pregnant-women-who-are-overweight
#9
Adriana V Gaitán, Merritt L Drewery, Carly A Thaxton, Kennet M Carabante, Ericka Seidemann, Karen Elkind-Hirsch, Carol J Lammi-Keefe
OBJECTIVE: To estimate dietary intake of pregnant women who are overweight, assess their omega-3 docosahexaenoic acid (DHA) status, and compare results between Black and White women. DESIGN: Cross-sectional study with a longitudinal component (dietary assessment). SETTING: Outpatient clinics at Woman's Hospital, Baton Rouge, Louisiana and telephone calls. PARTICIPANTS: Pregnant women (N = 21) who were overweight (body mass index = 25...
October 14, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29040742/intussusception-rate-aamong-uunder-five-children-before-introduction-of-rotavirus-vaccine-in-north-india
#10
Madhu Gupta, Ravi Kanojia, Ritesh Singha, Jaya Prasad Tripathy, Kamlesh Mahajan, Akshay Saxena, Arun Bansal, Jeyashree Muralidharan, Rajesh Kumar
Background: Baseline data on intussusception are needed to compare the intussusception rates following introduction of rotavirus vaccine. Methods: A hospital-based bidirectional surveillance (retrospective from 2009 to 2012; and prospective from 2013 to 2015) was set up in a tertiary care hospital in Chandigarh, India, to enrol children <5 years of age admitted with intussusception as per Brighton's classification, to estimate the hospital admission rate. Incidence of intussusception among infants and children <5 years of age was also estimated...
October 11, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29040678/extended-models-for-nosocomial-infection-parameter-estimation-and-model-selection
#11
Alun Thomas, Karim Khader, Andrew Redd, Molly Leecaster, Yue Zhang, Makoto Jones, Tom Greene, Matthew Samore
We consider extensions to previous models for patient level nosocomial infection in several ways, provide a specification of the likelihoods for these new models, specify new update steps required for stochastic integration, and provide programs that implement these methods to obtain parameter estimates and model choice statistics. Previous susceptible-infected models are extended to allow for a latent period between initial exposure to the pathogen and the patient becoming themselves infectious, and the possibility of decolonization...
October 12, 2017: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/29040656/barriers-to-the-success-of-an-electronic-pharmacovigilance-reporting-system-in-kenya-an-evaluation-three-years-post-implementation
#12
Oscar O Agoro, Sarah W Kibira, Jenny V Freeman, Hamish S F Fraser
Objective: Electronic pharmacovigilance reporting systems are being implemented in many developing countries in an effort to improve reporting rates. This study sought to establish the factors that acted as barriers to the success of an electronic pharmacovigilance reporting system in Kenya 3 years after its implementation. Materials and Methods: Factors that could act as barriers to using electronic reporting systems were identified in a review of literature and then used to develop a survey questionnaire that was administered to pharmacists working in government hospitals in 6 counties in Kenya...
October 12, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29040634/implementation-of-acute-care-patient-portals-recommendations-on-utility-and-use-from-six-early-adopters
#13
Lisa V Grossman, Sung W Choi, Sarah Collins, Patricia C Dykes, Kevin J O'Leary, Milisa Rizer, Philip Strong, Po-Yin Yen, David K Vawdrey
Objective: To provide recommendations on how to most effectively implement advanced features of acute care patient portals, including: (1) patient-provider communication, (2) care plan information, (3) clinical data viewing, (4) patient education, (5) patient safety, (6) caregiver access, and (7) hospital amenities. Recommendations: We summarize the experiences of 6 organizations that have implemented acute care portals, representing a variety of settings and technologies...
September 4, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29040609/improving-patient-safety-and-efficiency-of-medication-reconciliation-through-the-development-and-adoption-of-a-computer-assisted-tool-with-automated-electronic-integration-of-population-based-community-drug-data-the-rightrx-project
#14
Robyn Tamblyn, Nancy Winslade, Todd C Lee, Aude Motulsky, Ari Meguerditchian, Melissa Bustillo, Sarah Elsayed, David L Buckeridge, Isabelle Couture, Christina J Qian, Teresa Moraga, Allen Huang
Background and Objective: Many countries require hospitals to implement medication reconciliation for accreditation, but the process is resource-intensive, thus adherence is poor. We report on the impact of prepopulating and aligning community and hospital drug lists with data from population-based and hospital-based drug information systems to reduce workload and enhance adoption and use of an e-medication reconciliation application, RightRx. Methods: The prototype e-medical reconciliation web-based software was developed for a cluster-randomized trial at the McGill University Health Centre...
October 11, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29040608/risk-factors-for-resistance-and-mdr-in-community-urine-isolates-population-level-analysis-using-the-nhs-scotland-infection-intelligence-platform
#15
William Malcolm, Eilidh Fletcher, Kimberley Kavanagh, Ashutosh Deshpande, Camilla Wiuff, Charis Marwick, Marion Bennie
Background: Urinary tract infections (UTIs) are common. Antibiotic treatment is usually empirical, with the risk of under-treatment of resistant infections. Objectives: To characterize risk factors for antibiotic-resistant community urine isolates using routine record-linked health data. Methods: Within the NHS Scotland Infection Intelligence Platform, national surveillance patient-level data on community urine isolates (January 2012-June 2015) were linked to hospital activity and community prescribing data...
October 10, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29040606/pinopode-score-around-the-time-of-implantation-is-predictive-of-successful-implantation-following-frozen-embryo-transfer-in-hormone-replacement-cycles
#16
X Y Jin, L J Zhao, D H Luo, L Liu, Y D Dai, X X Hu, Y Y Wang, X Lin, F Hong, T C Li, S Y Zhang
STUDY QUESTION: Is pinopode measurement of any prognostic value? SUMMARY ANSWER: Pinopode expression was significantly associated with the occurrence of pregnancy after frozen embryo transfer. WHAT IS KNOWN ALREADY: Pinopodes are expressed in the endometrium during the implantation period. Pinopode measurement has been proposed as a marker of endometrial receptivity. STUDY DESIGN, SIZE, DURATION: A prospective cohort study was conducted at the Center of Reproductive Medicine, Sir Run Run Shaw Hospital, between 2014 and 2016, recruiting 172 women with infertility and undergoing frozen embryo transfer following IVF treatment...
October 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040587/does-low-to-moderate-environmental-exposure-to-noise-and-air-pollution-influence-preterm-delivery-in-medium-sized-cities
#17
Marie Barba-Vasseur, Nadine Bernard, Sophie Pujol, Paul Sagot, Didier Riethmuller, Gérard Thiriez, Hélène Houot, Jérôme Defrance, Anne-Sophie Mariet, Vinh-Phuc Luu, Alice Barbier, Eric Benzenine, Catherine Quantin, Frédéric Mauny
Background: Preterm birth (PB) is an important predictor of childhood morbidity and educational performance. Beyond the known risk factors, environmental factors, such as air pollution and noise, have been implicated in PB. In urban areas, these pollutants coexist. Very few studies have examined the effects of multi-exposure on the pregnancy duration. The objective of this study was to analyse the relationship between PB and environmental chronic multi-exposure to noise and air pollution in medium-sized cities...
July 14, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29040585/emergence-of-mcr-1-and-carbapenemase-genes-in-hospital-sewage-water-in-beijing-china
#18
Longyang Jin, Ruobing Wang, Xiaojuan Wang, Qi Wang, Yawei Zhang, Yuyao Yin, Hui Wang
Objectives: This study identified and characterized mcr-1-positive Enterobacteriaceae (MCRPE) and carbapenemase-producing Enterobacteriaceae (CPE) in hospital sewage water. Methods: Influent and effluent sewage samples were collected from five tertiary hospitals in Beijing in December 2016. Samples were screened for MCRPE and CPE using antibiotic selection media. Results were confirmed by PCR amplification of β-lactamase and colistin resistance (mcr-1 and mcr-2) genes and by sequencing...
October 10, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29040583/taste-receptor-polymorphisms-and-male-infertility
#19
M Gentiluomo, L Crifasi, A Luddi, D Locci, R Barale, P Piomboni, D Campa
STUDY QUESTION: Are polymorphisms of taste receptor genes associated with male infertility? SUMMARY ANSWER: This study has showed the associations between three single nucleotide polymorphisms (SNPs) in taste receptors genes (TASR) and male infertility. WHAT IS KNOWN ALREADY: Recent studies showed the expression of taste receptors in the testis and in spermatozoa, suggesting their possible role in infertility. The vast genetic variability in taste genes results in a large degree of diversity in various human phenotypes...
October 12, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040578/systemic-inflammation-induced-by-micrornas-endometriosis-derived-alterations-in-circulating-microrna-125b-5p-and-let7b-5p-regulate-macrophage-cytokine-production
#20
Sepide E Nematian, Ramanaiah Mamillapalli, Trisha S Kadakia, Masoumeh Majidi Zolbin, Sarah Moustafa, Hugh S Taylor
Context: Endometriosis is characterized by aberrant inflammation. We previously reported increased levels of miRNA 125b-5p and decreased levels of miRNA let 7b-5p in serum of patients with endometriosis. Objective: Determine the regulatory function of microRNAs 125b-5p and Let 7b-5p on production of pro-inflammatory cytokines in endometriosis. Design: Case-control study. Setting: University hospital. Patients: Women with (20) and without (26) endometriosis; human U937 macrophage cell line...
October 12, 2017: Journal of Clinical Endocrinology and Metabolism
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