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mthfr c677t ischemic stroke

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https://www.readbyqxmd.com/read/27378745/mthfr-c677t-ct-genotype-and-ct-apoe3-3-genotypic-combination-predisposes-the-risk-of-ischemic-stroke
#1
Murali Vijayan, Rathika Chinniah, Padma Malini Ravi, Ramgopal Sivanadham, Arun Kumar Mosses Joseph, Neethi Arasu Vellaiappan, Jeyaram Illiayaraja Krishnan, Balakrishnan Karuppiah
The predisposition to ischemic stroke (IS) might involve interactions of several genes and environmental factors. The present study was aimed to evaluate the influence of polymorphisms in methylenetetrahydrofolate reductase (MTHFR-C677T) and apolipoprotein-E (apo-E) as risk factors for IS patients in south Indian population. 200 IS patients and 193 age and sex matched controls were genotyped for MTHFR-C677T and apoE by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method. Statistically significant association was observed for MTHFR CT genotype (IS-Pooled: OR=4...
October 15, 2016: Gene
https://www.readbyqxmd.com/read/27017342/tgfbr2-mutation-and-mthfr-c677t-polymorphism-in-a-mexican-mestizo-population-with-cervico-cerebral-artery-dissection
#2
Angélica Ruiz-Franco, Miguel A Barboza, Aurelio Jara-Prado, Samuel Canizales-Quinteros, Paola Leon-Mimila, Nayelli Arguelles-Morales, Juan-Camilo Vargas-González, Alejandro Quiroz-Compean, Antonio Arauz
Spontaneous cervico-cerebral artery dissection (CCAD) is a common condition found among young patients with ischemic stroke. We examined the possible association between the polymorphism of methylenetetrahydrofolate reductase (MTHFR)-C677T and the gene mutation in transforming growth factor beta receptor II (TGFBR2) in a cohort of CCAD patients. One-hundred CCAD cases (65 males; mean age: 38.08 ± 10.68 years) and 100 matching controls were included. Ancestry informative markers (AIMs) were used to increase internal validity of the genetic analysis...
June 2016: Journal of Neurology
https://www.readbyqxmd.com/read/26951304/correlation-with-platelet-parameters-and-genetic-markers-of-thrombophilia-panel-factor-ii-g-20210g-a-factor-v-leiden-mthfr-c677t-a1298c-pai-1-%C3%AE-fibrinogen-factor-xiiia-v34l-glycoprotein-iiia-l33p-in-ischemic-strokes
#3
Sener Tasdemir, Haktan Bagis Erdem, Ibrahim Sahin, Lutfi Ozel, Gokhan Ozdemir, Recep Eroz, Abdulgani Tatar
An important type of arterial thrombosis, ischemic stroke is associated with increased mortality risk, severe disability and life quality impairment. In this study, we analyzed mean platelet volume, platelet count values and genetic thrombophilia markers of patients who have ischemic stroke history and searched the relationship with genetic predisposition of ischemic strokes and platelet parameters. A retrospective, clinical trial was performed by reviewing the ischemic stroke history (except cryptogenic events) of 599 patients and 100 controls...
June 2016: Neuromolecular Medicine
https://www.readbyqxmd.com/read/26839351/association-of-mthfr-c677t-genotype-with-ischemic-stroke-is-confined-to-cerebral-small-vessel-disease-subtype
#4
Loes C A Rutten-Jacobs, Matthew Traylor, Poneh Adib-Samii, Vincent Thijs, Cathie Sudlow, Peter M Rothwell, Giorgio Boncoraglio, Martin Dichgans, James Meschia, Jane Maguire, Christopher Levi, Natalia S Rost, Jonathan Rosand, Ahamad Hassan, Steve Bevan, Hugh S Markus
BACKGROUND AND PURPOSE: Elevated plasma homocysteine levels are associated with stroke. However, this might be a reflection of bias or confounding because trials have failed to demonstrate an effect from homocysteine lowering in stroke patients, although a possible benefit has been suggested in lacunar stroke. Genetic studies could potentially overcome these issues because genetic variants are inherited randomly and are fixed at conception. Therefore, we tested the homocysteine levels-associated genetic variant MTHFR C677T for association with magnetic resonance imaging-confirmed lacunar stroke and compared this with associations with large artery and cardioembolic stroke subtypes...
March 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/26797478/-a-case-of-vascular-parkinsonism-associated-with-hyperhomocysteinemia-and-methylenetetrahydrofolate-reductase-gene-variant-c677t
#5
Kenju Hara, Keigo Onda, Haruka Ouchi, Ken Shibano, Hideaki Ishiguro
A 56-year-old man, who presented with 6 years history of difficulty in walking, was diagnosed as having vascular parkinsonism on the basis of the clinical findings of parkinsonism, pyramidal sign and the brain MRI findings of multiple lacunar infarction. Although he did not have hypertension, he had hyperhomocysteinemia and homozygous methylenetetrahydrofolate reductase (MTHFR) gene variant (C677T) as risk factors for ischemic stroke. Recent studies have shown that hyperhomocysteinemia and MTHFR gene variant are associated with small-vessel disease, suggesting that these risk factors may underlie vascular parkinsonism, particularly in patients lacking hypertension and in those with a relatively younger age at onset of this disease...
2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/26776436/association-between-5-10-methylenetetrahydrofolate-reductase-c677t-gene-polymorphism-and-risk-of-ischemic-stroke-a-meta-analysis
#6
Yanli Song, Bohong Li, Chunjuan Wang, Penglian Wang, Xiang Gao, Gaifen Liu
BACKGROUND: Hyperhomocysteinemia, a condition that is strongly determined by dietary intake of B vitamins, has been suggested to be an independent risk factor for ischemic stroke (IS). To test this hypothesis, we performed a meta-analysis to investigate the associations between 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, which plays a critical role in modulating plasma homocysteine concentrations, and IS risk. MATERIALS AND METHODS: We searched case-control studies on the association between MTHFR C677T genetic polymorphism and susceptibility to IS through PubMed, Embase, and Medline databases from January 2000 up to October 2014...
March 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/26710338/interactions-among-candidate-genes-selected-by-meta-analyses-resulting-in-higher-risk-of-ischemic-stroke-in-a-chinese-population
#7
Man Luo, Jiaoxing Li, Xunsha Sun, Rong Lai, Yufang Wang, Xiaowei Xu, Wenli Sheng
Ischemic stroke (IS) is a multifactorial disorder caused by both genetic and environmental factors. The combined effects of multiple susceptibility genes might result in a higher risk for IS than a single gene. Therefore, we investigated whether interactions among multiple susceptibility genes were associated with an increased risk of IS by evaluating gene polymorphisms identified in previous meta-analyses, including methylenetetrahydrofolate reductase (MTHFR) C677T, beta fibrinogen (FGB, β-FG) A455G and T148C, apolipoprotein E (APOE) ε2-4, angiotensin-converting enzyme (ACE) insertion/deletion (I/D), and endothelial nitric oxide synthase (eNOS) G894T...
2015: PloS One
https://www.readbyqxmd.com/read/25966188/association-of-methylenetetrahydrofolate-reductase-mthfr-gene-polymorphism-with-ischemic-stroke-in-the-eastern-chinese-han-population
#8
Q-Q Lv, J Lu, H Sun, J-S Zhang
The association between the MTHFR genetic polymorphism and ischemic stroke has been reported by a number of investigators. However, the results have been controversial and conflicting. The aim of this study was to explore the association between the MTHFR variants C677T and A1298C and the risk of ischemic stroke in an Eastern Chinese Han population. A total of 199 patients with ischemic stroke and 241 controls were recruited. Genotyping of the MTHFR C677T and A1298C polymorphisms was carried out using the Taqman 7900HT Sequence Detection System...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/25771069/efficacy-of-folic-acid-therapy-in-primary-prevention-of-stroke-among-adults-with-hypertension-in-china-the-csppt-randomized-clinical-trial
#9
RANDOMIZED CONTROLLED TRIAL
Yong Huo, Jianping Li, Xianhui Qin, Yining Huang, Xiaobin Wang, Rebecca F Gottesman, Genfu Tang, Binyan Wang, Dafang Chen, Mingli He, Jia Fu, Yefeng Cai, Xiuli Shi, Yan Zhang, Yimin Cui, Ningling Sun, Xiaoying Li, Xiaoshu Cheng, Jian'an Wang, Xinchun Yang, Tianlun Yang, Chuanshi Xiao, Gang Zhao, Qiang Dong, Dingliang Zhu, Xian Wang, Junbo Ge, Lianyou Zhao, Dayi Hu, Lisheng Liu, Fan Fan Hou
IMPORTANCE: Uncertainty remains about the efficacy of folic acid therapy for the primary prevention of stroke because of limited and inconsistent data. OBJECTIVE: To test the primary hypothesis that therapy with enalapril and folic acid is more effective in reducing first stroke than enalapril alone among Chinese adults with hypertension. DESIGN, SETTING, AND PARTICIPANTS: The China Stroke Primary Prevention Trial, a randomized, double-blind clinical trial conducted from May 19, 2008, to August 24, 2013, in 32 communities in Jiangsu and Anhui provinces in China...
April 7, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/25713624/hereditary-thrombophilia-and-thrombotic-events-in-pregnancy-single-center-experience
#10
L Coriu, R Ungureanu, R Talmaci, V Uscatescu, M Cirstoiu, D Coriu, E Copaciu
Pregnancy is a normal physiological state that predisposes to thrombosis, determined by hormonal changes in the body. These changes occur in the blood flow (venous stasis), changes in the vascular wall (hypotonia, endothelial lesion) and changes in the coagulation factors (increased levels of factor VII, factor VIII, factor X, von Willebrand factor) and decreased activity levels of natural anticoagulants (protein C, protein S). In this study, we tried to determine a possible association between thrombosis and inherited thrombophilia in pregnant women...
October 2014: Journal of Medicine and Life
https://www.readbyqxmd.com/read/25699610/polymorphisms-in-prothrombotic-genes-in-young-stroke-patients-in-greece-a-case-controlled-study
#11
Kyriaki Ranellou, Anteia Paraskeva, Panagiotis Kyriazopoulos, Anna Batistatou, Aggelos Evangelou, Mahmoud El-Aly, Panagiotis Zis, Antonios Tavernarakis, Konstantinos Charalabopoulos
Mechanisms of ischemic stroke in young adults are poorly understood. The aim of the study was to investigate and compare the frequency of common variations in prothrombotic genes between young patients with ischemic stroke and controls. Fifty-one cases of first-ever ischemic stroke and 70 community-based controls aged below 50 years were studied. In both groups, the insertion/deletion 4G/5G variation (-675 4G/5G PAI-1) as well as the single-nucleotide polymorphism-844 G/A of the PAI-1 (-844 G/A PAI-1) gene promoter, factor V Leiden (FVL) G1691Α, the prothrombin variant (allele 20210A, FIIG20210A), factor XIII-A Val34Leu polymorphism (FXIII-AVal34Leu) and C677T methylenotetrahydrofolate reductase (C677T MTHFR) polymorphism have been assessed...
June 2015: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/25591425/association-of-c677t-polymorphism-in-the-methylenetetrahydrofolate-reductase-gene-mthfr-gene-with-ischemic-stroke-a-meta-analysis
#12
Amit Kumar, Pradeep Kumar, Manya Prasad, Ram Sagar, Arun Kumar Yadav, Awadh Kishor Pandit, Vidishaa Prasad Jali, Abhishek Pathak
OBJECTIVE: Studies on association between methylenetetrahydrofolate reductase gene (MTHFR) C677T gene polymorphism and ischemic stroke have shown conflicting results. We have conducted a meta-analysis to determine the precise association of the C677T polymorphism of MTHFR gene with risk of ischemic stroke. MATERIALS AND METHODS: We searched electronic databases Medline, EMBASE, and Google Scholar (last search dated till August 2014). Pooled odds ratios (ORs) with 95% confidence intervals (CIs) from random or fixed-effects models were calculated...
July 2015: Neurological Research
https://www.readbyqxmd.com/read/25453894/mthfr-c677t-mutation-increased-the-risk-of-ischemic-stroke-especially-in-large-artery-atherosclerosis-in-adults-an-updated-meta-analysis-from-38-researches
#13
Tao Cui
BACKGROUND: To date, many publications have evaluated the correlation between the Ethylenetetrahydrofolate reductase gene (MTHFR) C677T and Ischemic Stroke susceptibility in adults. However, the results remain inconclusive. The meta-analysis was performed to resolve the problem. METHODS: Based on 38 studies, dichotomous data were presented as the odds ratio (OR) with a 95% confidence interval (CI). RESULTS: This study found, the carriers of the MTHFR 677C→T variation were more likely to increase the risk of Ischemic Stroke susceptibility in all over pooled population, including Asian and European, but not in African population (Europe: TT vs...
2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/25440348/methylenetetrahydrofolate-reductase-gene-a1298c-polymorphism-in-pediatric-stroke-case-control-and-family-based-study
#14
Anna Balcerzyk, Paweł Niemiec, Ilona Kopyta, Ewa Emich-Widera, Ewa Pilarska, Karolina Pienczk-Ręcławowicz, Marek Kaciński, Janusz Wendorff, Iwona Żak
Moderate hyperhomocysteinemia is one of the risk factors of pediatric stroke. Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme, which regulates homocysteine metabolism, and some polymorphisms of gene encoding this enzyme are associated with a decreased activity of the enzyme. The aim of the study was to assess an association between the A1298C polymorphism and pediatric stroke. We also evaluated a possible synergistic effect of A1298C and C677T polymorphisms of this gene. The study group consisted of 88 children after ischemic stroke, 142 of their parents and 111 controls...
January 2015: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/25375269/association-between-the-methylenetetrahydrofolate-reductase-mthfr-gene-c677t-polymorphism-and-ischemic-stroke-in-the-chinese-population-a-meta-analysis
#15
REVIEW
Xiao-Yan Zhu, Rong-Yao Hou, Xu-Dong Pan, Yu-Chun Wang, Zheng-Shou Zhang, Rui-You Guo
PURPOSE: The association between the methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and ischemic stroke (IS) has been extensively studied; however, the results from genetic association studies have been inconsistent even in the Chinese population. As far as we know, there was no previous meta-analysis concerning this association in the Chinese population. Therefore, the aim of our meta-analysis was to further evaluate the association in the Chinese population. METHODS: We collected all of the relevant studies from Pubmed, OVID, Embase, Chinese Wan Fang database, CNKI, Chongqing VIP database and CBM up to August 2014...
2015: International Journal of Neuroscience
https://www.readbyqxmd.com/read/25031284/homocysteine-small-vessel-disease-and-atherosclerosis-an-mri-study-of-825-stroke-patients
#16
Sang-Beom Jeon, Dong-Wha Kang, Jong S Kim, Sun U Kwon
OBJECTIVE: We evaluated the relationship between hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and small-vessel disease (SVD) and atherosclerotic large-vessel disease (LVD) in stroke patients. METHODS: A total of 825 noncardioembolic ischemic stroke patients whose plasma concentrations of total homocysteine were measured and whose MTHFR C677T polymorphism status was identified were included in this retrospective study. MRI of the brain and magnetic resonance angiography of the intracranial and extracranial cerebral arteries had been performed...
August 19, 2014: Neurology
https://www.readbyqxmd.com/read/24974211/cerebral-ultrasound-abnormalities-in-offsprings-of-women-with-c677t-homozygous-mutation-in-the-mthfr-gene-a-prospective-study
#17
Laura Pogliani, Chiara Cerini, Francesca Penagini, Piergiorgio Duca, Chiara Mameli, Gian Vincenzo Zuccotti
BACKGROUND: Perinatal stroke is a common cause of neurologic disability. Being clinically under-recognized, its true incidence is not known. Maternal thrombophilia is likely to be a predisposing factor. To date, a general consensus for evaluation of babies born to mothers with genetic thrombotic predisposition is missing. This study was undertaken to assess the frequency of cerebral abnormalities in the offspring of women with homozygous C677T mutation in the MTHFR gene, and to seek for association with additional maternal or pregnancy risk factors...
May 2015: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/24903192/hyperhomocysteinemia-and-methylenetetrahydrofolate-reductase-polymorphism-in-cervical-artery-dissection-a-meta-analysis
#18
Hongzhi Luo, Bo Liu, Jing Hu, Xian Wang, Siyan Zhan, Wei Kong
BACKGROUND: Cervical artery dissection (CAD) is a recognized cause of ischemic stroke. Hyperhomocysteinemia (HHcy), i.e. an elevated concentration of plasma homocysteine, is identified as an independent risk factor for stroke prevalence. However, an association between HHcy and CAD has so far remained unknown. METHODS: A meta-analysis was performed to analyze the association between HHcy and CAD as well as the relevance of the C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR), the key enzyme in homocysteine metabolism during CAD...
2014: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/24189452/the-role-of-classic-risk-factors-and-prothrombotic-factor-gene-mutations-in-ischemic-stroke-risk-development-in-young-and-middle-aged-individuals
#19
Visnja Supanc, Zdenko Sonicki, Ines Vukasovic, Vesna V Solter, Iris Zavoreo, Vanja B Kes
BACKGROUND: In young individuals, a genetically predisposing hypercoagulability and classic modifying risk factors can act synergistically on the ischemic stroke risk development. The aim of the study was to compare the prevalence of classic vascular risk factors and polymorphisms of the G20210A coagulation factor II (prothrombin), Arg506Glu coagulation factor V Leiden, C677T methylenetetrahydrofolate reductase (MTHFR), and 4G/5G plasminogen activator inhibitor-1 (PAI-1) and the impact of these gene mutations and classic vascular risk factors on the overall stroke risk in individuals aged 55 years or younger...
March 2014: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/24140489/methylenetetrahydrofolate-reductase-mthfr-gene-polymorphisms-and-susceptibility-to-ischemic-stroke-a-meta-analysis
#20
Pingping Li, Chao Qin
Associations between 5,10-methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and ischemic stroke have been reported (Ariyaratnam et al., 2007; Banerjee et al., 2007; Casas et al., 2004), but the results of these studies are inconsistent. To investigate the possible associations between the MTHFR gene polymorphism and ischemic stroke, we performed a meta-analysis. Nineteen case-control studies associated with MTHFR gene C667T involving 2223 cases and 2936 controls were included. Heterogeneity among studies was evaluated with I(2) and Egger's test and an inverted funnel plot was used to assess publication bias...
February 10, 2014: Gene
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