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Jiankui Feng, Erwei Yin, Jing Jin, Rami Saab, Ian Daly, Xingyu Wang, Dewen Hu, Andrzej Cichocki
The start of the cue is often used to initiate the feature window used to control motor imagery (MI)-based brain-computer interface (BCI) systems. However, the time latency during an MI period varies between trials for each participant. Fixing the starting time point of MI features can lead to decreased system performance in MI-based BCI systems. To address this issue, we propose a novel correlation-based time window selection (CTWS) algorithm for MI-based BCIs. Specifically, the optimized reference signals for each class were selected based on correlation analysis and performance evaluation...
March 2, 2018: Neural Networks: the Official Journal of the International Neural Network Society
Daniel Schwarzkopf, Carolin Fleischmann-Struzek, Hendrik Rüddel, Konrad Reinhart, Daniel O Thomas-Rüddel
BACKGROUND: Sepsis is a major cause of preventable deaths in hospitals. Feasible and valid methods for comparing quality of sepsis care between hospitals are needed. The aim of this study was to develop a risk-adjustment model suitable for comparing sepsis-related mortality between German hospitals. METHODS: We developed a risk-model using national German claims data. Since these data are available with a time-lag of 1.5 years only, the stability of the model across time was investigated...
2018: PloS One
Khurram Ashfaq Qazi, Tabassam Nawaz, Zahid Mehmood, Muhammad Rashid, Hafiz Adnan Habib
Recent research on speech segregation and music fingerprinting has led to improvements in speech segregation and music identification algorithms. Speech and music segregation generally involves the identification of music followed by speech segregation. However, music segregation becomes a challenging task in the presence of noise. This paper proposes a novel method of speech segregation for unlabelled stationary noisy audio signals using the deep belief network (DBN) model. The proposed method successfully segregates a music signal from noisy audio streams...
2018: PloS One
Ali Hassan Sodhro, Arun Kumar Sangaiah, Gul Hassan Sodhro, Sonia Lohano, Sandeep Pirbhulal
Rapid progress and emerging trends in miniaturized medical devices have enabled the un-obtrusive monitoring of physiological signals and daily activities of everyone's life in a prominent and pervasive manner. Due to the power-constrained nature of conventional wearable sensor devices during ubiquitous sensing (US), energy-efficiency has become one of the highly demanding and debatable issues in healthcare. This paper develops a single chip-based wearable wireless electrocardiogram (ECG) monitoring system by adopting analog front end (AFE) chip model ADS1292R from Texas Instruments...
March 20, 2018: Sensors
Longcan Mei, Yanping Zhou, Lizhe Zhu, Changlin Liu, Zhuo Wu, Fangkui Wang, Gefei Hao, Di Yu, Hong Yuan, Yanfang Cui
A superkine variant of interleukin-2 with six site mutations away from the binding interface developed from the yeast display technique has been previously characterized as undergoing a distal structure alteration which is responsible for its super-potency and provides an elegant case study with which to get insight about how to utilize allosteric effect to achieve desirable protein functions. By examining the dynamic network and the allosteric pathways related to those mutated residues using various computational approaches, we found that nanosecond time scale all-atom molecular dynamics simulations can identify the dynamic network as efficient as an ensemble algorithm...
March 20, 2018: International Journal of Molecular Sciences
Olga Dergachyova, Yulong Zhao, Claire Haegelen, Pierre Jannin, Caroline Essert
PURPOSE: Deep brain stimulation (DBS) is a procedure requiring accurate targeting and electrode placement. The two key elements for successful planning are preserving patient safety by ensuring a safe trajectory and creating treatment efficacy through optimal selection of the stimulation point. In this work, we present the first approach of computer-assisted preoperative DBS planning to automatically optimize both the safety of the electrode's trajectory and location of the stimulation point so as to provide the best clinical outcome...
March 20, 2018: International Journal of Computer Assisted Radiology and Surgery
Raj G Kumar, Zhensheng Wang, Matthew R Kesinger, Mark Newman, Toan T Huynh, Janet P Niemeier, Jason L Sperry, Amy K Wagner
In a previous study, individuals from a single Traumatic Brain Injury Model Systems and trauma center were matched using a novel probabilistic matching algorithm. The Traumatic Brain Injury Model Systems is a multicenter prospective cohort study containing more than 14,000 participants with traumatic brain injury, following them from inpatient rehabilitation to the community over the remainder of their lifetime. The National Trauma Databank is the largest aggregation of trauma data in the United States, including more than 6 million records...
April 2018: American Journal of Physical Medicine & Rehabilitation
Shigeki Hashimoto, Chota Matsumoto, Mariko Eura, Sachiko Okuyama, Hiroki Nomoto, Fumi Tanabe, Tomoyasu Kayazawa, Aiko Iwase, Yoshikazu Shimomura
PURPOSE: To evaluate the distribution and progression of glaucomatous visual field (VF) defects with binocular vision. PATIENTS AND METHODS: Subjects were 167 patients (average age, 67±10.7▒y) with glaucoma who received the Humphrey 24-2 VF test (SITA-Standard) for the two eyes. Using the Best Location Algorithm, patient's integrated binocular VF (IVF) was calculated from their Humphrey 24-2 results. Of 167, 77 subjects (average age, 68±11.0▒y) also underwent monocular/binocular Humphrey Esterman tests...
March 19, 2018: Journal of Glaucoma
Pierre Yger, Giulia Lb Spampinato, Elric Esposito, Baptiste Lefebvre, Stéphane Deny, Christophe Gardella, Marcel Stimberg, Florian Jetter, Guenther Zeck, Serge Picaud, Jens Duebel, Olivier Marre
In recent years, multielectrode arrays and large silicon probes have been developed to record simultaneously between hundreds and thousands of electrodes packed with a high density. However, they require novel methods to extract the spiking activity of large ensembles of neurons. Here we developed a new toolbox to sort spikes from these large-scale extracellular data. To validate our method, we performed simultaneous extracellular and loose patch recordings in rodents to obtain 'ground truth' data, where the solution to this sorting problem is known for one cell...
March 20, 2018: ELife
Marco Baldrighi, Pier Paolo Sainaghi, Mattia Bellan, Ettore Bartoli, Luigi Mario Castello
INTRODUCTION: Although hypovolemia remains the most relevant problem during acute decompensated diabetes in its clinical manifestations (diabetic ketoacidosis, DKA, and hyperglycemic hyperosmolar state, HHS), the electrolyte derangements caused by the global hydroelectrolytic imbalance usually complicate the clinical picture at presentation and may be worsened by treatment itself. AIM: This review article is focused on the management of dysnatremias during hyperglycemic hyperosmolar state with the aim of providing clinicians a useful tool to early indentify the sodium derangement in order to address properly its treatment...
March 19, 2018: Current Diabetes Reviews
Paul P Walker, Pasquale P Pompilio, Paolo Zanaboni, Trine S Bergmo, Kaiu Prikk, Andrei Malinovschi, Josep M Montserrat, Jo Middlemass, Silvana Šonc, Giulia Munaro, Dorjan Marušič, Ruth Sepper, Roberto Rosso, A Niroshan Siriwardena, Christer Janson, Ramon Farre, Peter M A Calverley, Raffaele L Dellaca'
RATIONALE: Early detection of COPD exacerbations using tele-monitoring of physiological variables might reduce the frequency of hospitalisation. OBJECTIVES: To evaluate the efficacy of home monitoring of lung mechanics by the forced oscillation technique (FOT) and cardiac parameters in older COPD patients with co-morbidities. METHODS: This multicentre, randomized clinical trial recruited 312 GOLD grade II-IV COPD patients (median age 71 years [IQR:66-76], 49...
March 20, 2018: American Journal of Respiratory and Critical Care Medicine
Basant Kumar, Vijai Dutta Upadhyaya, Sandeep Kumar Rahul, Laxmi Kant Bharti, Ram Nawal Rao, Sheo Kumar
Background: To analyse our experience with acute presentations of abdominal tuberculosis (TB) in children for early diagnosis and management. Materials and Methods: From December 2010 to April 2016, available electronic and operation theatre (OT) records of 17 patients with confirmed diagnosis of abdominal TB were analysed retrospectively. Parameters reviewed were age, sex, presentations, diagnostic investigations, surgery/intervention performed, final outcome and follow-up...
July 2017: African Journal of Paediatric Surgery: AJPS
Scott J Lee, Jianmin Liu, Jianhua Yao, Andrew Kanarek, Ronald M Summers, Perry J Pickhardt
OBJECTIVE: To investigate a fully-automated CT-based adiposity tool, applying it to a longitudinal adult screening cohort. METHODS: A validated automated adipose tissue segmentation algorithm was applied to non-contrast abdominal CT scans in 8852 consecutive asymptomatic adults (mean age, 57.1 years; 3926M/4926F) undergoing colonography screening. The tool was also applied to follow-up CT scans in a subset of 1584 individuals undergoing longitudinal surveillance (mean interval, 5...
March 20, 2018: British Journal of Radiology
Muge Yucel, Osman Akin, Mehmet Cayoren, Ibrahim Akduman, Alagappan Palaniappan, Bo Liedberg, Gurkan Hizal, Fatih Inci, Umit Hakan Yildiz
This study reports on a handheld volatilome analyzer for selective determination of clinically relevant biomarkers in exhaled breath. The sensing platform is based on electrospun polymer nanofiber-multi walled carbon nanotube (MWCNT) sensing micro-channels. Polymer nanofibers of poly(vinylidene fluoride) (PVDF), polystyrene (PS), and poly(methyl methacrylate) (PMMA) incorporated with MWCNT exhibits stable response to interferences of humidity and CO2 and provides selective deformations upon exposure of exhaled breath target volatilomes acetone and toluene, exhibiting correlation to diabetes and lung cancer, respectively...
March 20, 2018: Analytical Chemistry
Wonho Kim, Donghoon Choi
Femoropopliteal (FP) artery-in stent restenosis (ISR) is a daunting management problem that we continue to face. FP artery-ISR rates after primary stent implantation are relatively high. Although repeat FP artery-ISR and the need for additional interventions remain all too common, little consensus exists regarding the best treatment algorithm. In this article, we review the limitations of the currently used devices for the endovascular treatment of FP artery-ISR and discuss which strategies are the most effective and safe...
March 2018: Korean Circulation Journal
Thijs T Wingelaar, Paul Clarijs, Pieter-Jan Am van Ooij, Dave Aa Koch, Rob A van Hulst
INTRODUCTION: Pulmonary function testing (PFT) is an important part of dive medical examinations. Depending on the standard used to assess fitness to dive, different reference sets and fixed cut-off points are used. Reference values are part of an ongoing debate regarding the validity and accuracy related to different age groups, sex and ethnic backgrounds. The Global Lung Initiative (GLI) has provided an all-age reference set which corrects for sex and ethnicity (GLI-2012); this has had substantial impact on pulmonary medicine...
March 31, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
Sonia-Yuki Selmi, Emmanuel Promayon, Jocelyne Troccaz
PURPOSE: We present a hybrid 2D-3D ultrasound (US) rigid registration method for navigated prostate biopsy that enables continuous localization of the biopsy trajectory during the exam. METHODS: Current clinical computer-assisted biopsy systems use either sensor-based or image-based approaches. We combine the advantages of both in order to obtain an accurate and real-time navigation based only on an approximate localization of the US probe. Starting with features extracted in both 2D and 3D images, our method introduces a variant of the iterative closest point (ICP) algorithm...
March 20, 2018: International Journal of Computer Assisted Radiology and Surgery
Carmen Pheiffer, Stephanie Dias, Paul Rheeder, Sumaiya Adam
BACKGROUND AND OBJECTIVE: In recent years circulating microRNAs (miRNAs) have attracted interest as biomarkers of metabolic disease. MiRNA expression varies across population groups; thus, the aim of this study was to investigate whether serum miRNAs that have previously been shown to be associated with gestational diabetes mellitus (GDM) in other populations, are similarly regulated in South African women with GDM. METHODS: In this case-control study, women (n = 81) were selected from a prospective cohort study in which pregnant women were recruited at their first clinic visit and requested to return for fasting blood glucose concentration measurements and serum collection (median 27 weeks; range 13-31 weeks)...
March 19, 2018: Molecular Diagnosis & Therapy
Mark Clemons
Numerous groups have published guidelines for the prevention and management of chemotherapy-induced nausea and vomiting (CINV). The current management of CINV, however, remains suboptimal, due in part to poor adherence to existing antiemetic guidelines. Challenges in clinical trial design have also slowed progress and complicated the selection of optimal antiemetic therapy. In addition, patient-specific characteristics and factors are not included in current CINV guidelines and are an important contributor to an individual's risk for nausea and vomiting...
March 19, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Syeda Hira Fatima, Farrah Zaidi, Muhammad Adnan, Asad Ali, Qaiser Jamal, Muhammad Khisroon
Contemporary studies demonstrate that rodent bites do not occur frequently. However, a huge number of cases were reported from Peshawar vale, Pakistan during 2016. Two species, the local black rat Rattus rattus (Linnaeus, 1758) and the invasive brown rat Rattus norvegicus (Berkenhout, 1769) might be the suspected cause. Several studies indicated the invasion of brown rats into Pakistan presumably via port city of Karachi. In this study, we modeled geospatial distribution of rodent bites for risk assessment in the region...
March 19, 2018: Environmental Monitoring and Assessment
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