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https://www.readbyqxmd.com/read/29238914/clinical-and-genetic-implications-of-dna-mismatch-repair-deficiency-in-biliary-tract-cancers-associated-with-lynch-syndrome
#1
Jordan M Cloyd, Yun Shin Chun, Naruhiko Ikoma, Jean Nicolas Vauthey, Tlhomas A Aloia, Amanda Cuddy, Miguel A Rodriguez-Bigas, Y Nancy You
PURPOSE: Patients with Lynch syndrome (LS) have a significantly elevated lifetime risk of developing biliary tract cancers (BTCs) compared to the general population. However, few studies have characterized the clinical characteristics, genetic features, or long-term outcomes of mismatch-repair deficient (dMMR) cholangiocarcinomas associated with LS. METHODS: A retrospective review of a prospectively maintained Familial High-Risk GI Cancer Clinic database identified all patients with BTCs evaluated from 2006 to 2016 who carried germline mutations in MLH1, MSH2, MSH6, or PMS2...
December 14, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29231605/-clinical-research-of-mild-and-moderate-lumbar-disc-herniation-of-blood-stagnation-syndrome-treated-with-qi-conducting-needling-technique-at-the-governor-vessel-acupoints-combined-with-electroacupuncture
#2
Yaochi Wu, Yijun Sun, Junfeng Zhang, Yan Li, Chongmiao Wang
OBJECTIVE: To compare the difference in the clinical therapeutic effects on mild and moderate lumbar disc herniation (LDH) of blood stagnation syndrome between qi-conducting needling technique at the governor vessel acupoints combined with electroacupuncture (EA) and conventional EA. METHODS: Two hundred and one patients of LDH at the mild and moderate stage, differentiated as blood stagnation syndrome were randomized into an observation group (101 cases) and a control group (100 cases)...
May 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231598/-analysis-on-the-laws-of-acupoint-selection-and-therapeutic-operations-with-acupuncture-based-on-the-characteristics-of-postherpetic-neuralgia
#3
Lei Wang, Qingchen Zhou, Hongfang Tian, Jiping Zhao
Postherpetic neuralgia is manifested as drastic lingering pain, which seriously impacts the survival quality of patient. In the paper, focusing on the time of postherpetic neuralgia and in association with the characteristics of symptoms such as the location and nature of pain and skin lesion, the etiology, location of sickness, nature of sickness and pathogenesis were differentiated, and the laws of acupoint selection and therapeutic operations were explored in the treatment with acupuncture. Regarding the apparent pain at night, especially during 23:00 to 3:00, Ashi points (Extra) and Jiaji (EX-B 2) were selected in terms of location differentiation...
April 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231557/-discussion-on-rules-of-acupoint-selection-for-vascular-dementia
#4
Shuai Li, Jie Tan, Hong Zhang, Guilan Huang, Duoxi Deng, Quanrui Jiang
OBJECTIVE: The clinical research literature regarding acupuncture treatment for vascular dementia was reviewed and analyzed to provide the references for clinical selection and compatibility of acupoints. METHODS: With computer and manual retrieval method, the clinical literature regarding acupuncture treatment for vascular dementia in recent 10 years was collected. The acupoint type, meridian and use frequency were analyzed. RESULTS: Totally 38 articles of acupuncture treatment for vascular dementia were screened; the most selected meridians were the governor vessel, gallbladder meridian, stomach meridian and spleen meridian; the main acupoints with frequency of more than 5 times were Baihui (GV 20), Sishencong (EX-HN 1), Shenting (GV 24), Fengchi (SP 40) and Shuigou (GV 26); the matching acupoints with frequency of more than 5 times were Fenglong (ST 40), Zusanli (ST 36), Taichong (LR 3), Taixi (KI 3), Sanyinjiao (SP 6), Xuehai (SP 10), Zhongwan (CV 12), Neiguan (PC 6), Fengchi (GB 20)...
July 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231509/-summary-of-professor-yang-jun-s-experience-for-intractable-facial-paralysis
#5
Tao Wang, Zaiyuan Li, Tingqiu Ge, Man Zhang, Aihong Yuan, Jun Yang
Professor YANG Jun's experience of diagnosis and treatment for intractable facial paralysis is introduced. Professor YANG focuses on the thinking model that combines TCM, western medicine and acupuncture, and adopts the differentiation system that combines disease differentiation, syndrome differentiation and meridian differentiation; he adopts the treatment integrates etiological treatment, overall regulation, symptomatic treatment as well as acupuncture, moxibustion, medication and flash cupping. The acupoints of yangming meridians are mostly selected, and acupoints of governor vessel such as Dazhui (GV 14) and Jinsuo (GV 8) are highly valued...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231499/-different-acupuncture-and-moxibustion-methods-at-heding-ex-le-2-for-knee-osteoarthritis-with-yang-deficiency-and-cold-stagnation-syndrome
#6
Jia Zheng, Hui Zhang, Jianwu Liu
OBJECTIVE: To observe the differences for knee osteoarthritis (KOA) with yang-deficiency and cold-stagnation syndrome among acupuncture plus ginger moxibustion at Heding (EX-LE 2) on the affected side, simple acupuncture and simple ginger moxibustion at the same acupoint. METHODS: Ninety patients were randomly assigned into an acupuncture group, a ginger moxibustion group and a combination group, 30 cases in each one. Acupuncture was used in the three groups at bilateral Liangqiu (ST 34), Xuehai (SP 10), and Dubi (ST 35), Neixiyan (EX-LE 4), Yanglingquan (GB 34), Zusanli (ST 36), Yinlingquan (SP 9), Sanyinjiao (SP 6), Xuanzhong (GB 39), Taichong (LR 3) on the affected side...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29230280/a-case-of-mirizzi-syndrome-that-was-successfully-treated-by-laparoscopic-choledochoplasty-using-a-gallbladder-patch
#7
Masatsugu Hiraki, Junji Ueda, Hiroshi Kono, Noriyuki Egawa, Kiyoshi Saeki, Yasuhiro Tsuru, Takao Ide, Hirokazu Noshiro
The use of laparoscopic surgery in the treatment of Mirizzi syndrome is considered controversial due to the degree of technical difficulty. We herein describe the case of a 36-year-old woman who was admitted to our hospital due to appetite loss, nausea and back pain. Endoscopic retrograde cholangiography revealed a round-shaped filling defect at the confluence of the bile duct. The patient was diagnosed with Mirizzi syndrome Type II according to the Csendes classification. Before surgery, an endoscopic nasobiliary drainage tube was placed for intraoperative cholangiography...
November 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29217901/xanthogranulomatous-cholecystitis-analysis-of-108-patients
#8
Osman Yucel, Mehmet Ali Uzun, Metin Tilki, Sevcan Alkan, Zeynep Gamze Kilicoglu, Ceren Canbey Goret
The aim of this study was to evaluate the clinical and radiological features of xanthogranulomatous cholecystitis (XGC) and the results of surgical treatment. This retrospective study concerns clinical, radiological, and surgical data as well as histopathological findings and postoperative results of 108 patients with XGC who were identified after evaluating 7916 cholecystectomy specimens between 2004 and 2014 in a single institute. One hundred eight patients with XGC were evaluated (56 males and 52 females, mean age 62...
December 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29212931/suppression-of-zika-virus-infection-and-replication-in-endothelial-cells-and-astrocytes-by-pka-inhibitor-pki-14-22
#9
Fan Cheng, Suzane Ramos da Silva, I-Chueh Huang, Jae U Jung, Shou-Jiang Gao
The recent outbreak of Zika virus (ZIKV), a re-emerging flavivirus, and its associated neurological disorders, such as Guillain-Barré (GB) syndrome and microcephaly, have generated an urgent need for developing effective ZIKV vaccines and therapeutic agents. Here, we used human endothelial cells and astrocytes, both of which represent key cell types for ZIKV infection, to identify potential inhibitors for ZIKV replication. Because several pathways, including AMP-activated protein kinase (AMPK), protein kinase A (PKA), and mitogen-activated protein kinase (MAPK) signaling pathways, have been reported to play important roles in flavivirus replication, we tested inhibitors or agonists of these pathways for their effects on ZIKV replication...
December 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29196926/glioblastoma-and-acute-myeloid-leukemia-malignancies-with-striking-similarities
#10
REVIEW
Eric Goethe, Bing Z Carter, Ganesh Rao, Naveen Pemmaraju
Acute myeloid leukemia (AML) and glioblastoma (GB) are two malignancies associated with high incidence of treatment refractoriness and generally, uniformly poor survival outcomes. While the former is a hematologic (i.e. a "liquid") malignancy and the latter a solid tumor, the two diseases share both clinical and biochemical characteristics. Both diseases exist predominantly in primary (de novo) forms, with only a small subset of each progressing from precursor disease states like the myelodysplastic syndromes or diffuse glioma...
December 1, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29190931/cancer-mortality-trends-in-an-industrial-district-of-shanghai-china-from-1974-to-2014-and-projections-to-2029
#11
Mi Li, Shuo Wang, Xue Han, Wenbin Liu, Jiahui Song, Hongwei Zhang, Jia Zhao, Fan Yang, Xiaojie Tan, Xi Chen, Yan Liu, Hui Li, Yibo Ding, Xiaoyu Du, Jianhua Yin, Rong Zhang, Guangwen Cao
We aimed to characterize the trends and projections of cancer mortalities in Yangpu, an industry restructuring district of Shanghai, China. With high-quality data from the death registration system, the authors analyzed the trends in cancer mortalities during 1974-2014 and their relationship with pollution control and socioeconomic improvements. Cancer burden was projected into 2029. During 1974-2014, cancer death accounted for 28.80% of all-cause death. The 5 leading causes of cancer death were cancers of the lung & bronchus, stomach, liver, colon & rectum, and esophagus...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29162403/cope-s-sign-and-complete-heart-block-in-a-78-year-old-patient-with-biliary-colic
#12
Panteleimon E Papakonstantinou, Natalia I Asimakopoulou, Emmanuel Kanoupakis, Spyridon Maragkoudakis, Simeon Panagiotakis, Achilleas Gikas
INTRODUCTION: Acute cholecystitis and biliary colic may have signs and symptoms similar to those of Acute Coronary Syndrome(ACS) along with ischemic ECG changes. Cholecystitis and/or biliary colic have been both reported as trigger factors for bradyarrhythmia in the literature. CASE REPORT: A 78-year-old male patient was admitted to our Emergency Department (ED) due to acute abdominal pain. The ECG on admission showed sinus bradycardia with a rate of 40 beats per minute (bpm) without signs of acute ischemia and a brief period (7 s) of complete atrioventricular (AV) block...
November 18, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/29132116/the-outcome-of-laparoscopic-subtotal-cholecystectomy-in-difficult-cases-a-case-series
#13
Caroline Supit, Tommy Supit, Yarman Mazni, Ibrahim Basir
INTRODUCTION: Laparoscopic subtotal cholecystectomy (LSC) is a widely used technique for managing cholelithiasis with severe cholecystitis. The increasing popularity its utilization is due to the good safety profile and acceptable results. This case series evaluates the short- and long-term results of Indonesian patients who underwent LSC with an objective to determine whether the procedure can be a standard approach for difficult cholecystectomy in our institution. PRESENTATION OF CASE: Thirty-four Indonesian patients (26 men, 8 women) with the mean age of 54...
November 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29117670/association-between-dietary-intake-and-postlaparoscopic-cholecystectomic-symptoms-in-patients-with-gallbladder-disease
#14
Yongju Shin, Dongho Choi, Kyeong Geun Lee, Ho Soon Choi, Yongsoon Park
Background/Aims: After cholecystectomy, patients have reported postcholecystectomic syndromes such as abdominal symptoms, dyspepsia, and diarrhea, which suggest a relationship between cholecystectomic symptoms and diet, although the details of this association remain unclear. The present study investigated the hypothesis that dietary intake of nutrients and foods was significantly associated with postcholecystectomic syndromes. Methods: Gallstone patients (n = 59) who underwent laparoscopic cholecystectomy were enrolled, and dietary intake and clinical parameters were assessed immediately postcholecystectomy and 3 months later...
November 10, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29090081/eluxadoline-in-irritable-bowel-syndrome-with-diarrhea-rationale-evidence-and-place-in-therapy
#15
REVIEW
Kenneth Barshop, Kyle Staller
Irritable bowel syndrome (IBS) is the most common gastrointestinal (GI) disorder worldwide, however treatment options for diarrhea-predominant IBS (IBS-D) remain limited. Eluxadoline, a µ- and κ-opioid receptor agonist and δ-opioid receptor antagonist, was recently approved for the treatment of IBS-D. A novel compound first described in 2008, eluxadoline was shown to normalize GI transit, with a subsequent phase I demonstrating its safety and tolerability in healthy adults. In 2016, two randomized, double-blind, placebo-controlled phase III trials studying eluxadoline use at 75 mg and 100 mg twice daily over 26 weeks demonstrated a significant improvement in stool consistency and many global symptoms of IBS...
November 2017: Therapeutic Advances in Chronic Disease
https://www.readbyqxmd.com/read/29071205/disseminated-paracoccidioidomycosis-prediagnosticated-as-neoplasm-an-important-challenge-in-diagnosis-using-rt-pcr
#16
Fabiana Rocha-Silva, Cássio Ferreira Guimarães, Edmundo Rocha de Oliveira Júnior, Sônia Maria de Figueiredo, Rachel Basques Caligiorne
This paper presents a case of disseminated paracoccidioidomycosis in a 62-year-old male patient, who lives in Belo Horizonte, MG, Brazil. The patient was hospitalized with icteric syndrome of cholestatic pattern and weight loss, with loss 30 kg in 5 months. The imaging of the abdomen showed lesion of infiltrative pattern, affecting gallbladder and intrahepatic bile ducts, suggesting neoplasia of malignant behavior, besides to presenting the yellow nail syndrome. Dermatological examination presented erythematous-infiltrated plaques in the occipital region...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29057181/allopurinol-induced-drug-reaction-with-eosinophilia-and-systemic-symptoms-syndrome-a-cause-of-acalculous-cholecystitis
#17
Husnain Waseem, Faisal Inayat, Madina Abduraimova, Stephan Kamholz
Acalculous cholecystitis (AC) is an inflammation of the gallbladder in the absence of gallstones. There are many risk factors associated with AC. However, this report implicates allopurinol as an inciting agent for a severe systemic drug reaction, i.e., the drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome complicated by AC. We report a Chinese woman who presented on two occasions with a diffuse maculopapular rash, elevated liver enzymes, and upper abdominal pain attributable to acute AC, the second episode of which developed after the reintroduction of allopurinol treatment for gout...
August 16, 2017: Curēus
https://www.readbyqxmd.com/read/29033544/eluxadoline-in-the-treatment-of-diarrhea-predominant-irritable-bowel-syndrome
#18
REVIEW
Ayşe Elif Özdener, Anastasia Rivkin
Eluxadoline is a novel drug approved for the management of diarrhea predominant irritable bowel syndrome (IBS-D). It has unique pharmacology and works on three different opioid receptors. Several Phase II and III clinical trials have demonstrated eluxadoline's efficacy in reducing symptoms related to IBS-D. Clinical trial results and postmarketing reports show a risk of pancreatitis in patients without a gallbladder or those abusing alcohol. This review article will include information on clinical trial results related to IBS-D management as well as eluxadoline's limitations...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28965364/bupropion-for-attention-deficit-hyperactivity-disorder-adhd-in-adults
#19
REVIEW
Wim Verbeeck, Geertruida E Bekkering, Wim Van den Noortgate, Cornelis Kramers
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is a prevalent neurobiological condition, characterised by behavioral and cognitive symptoms such as inattention, impulsivity and/or excessive activity. The syndrome is commonly accompanied by psychiatric comorbidities and is associated with educational and occupational underachievement.Although psychostimulant medications are the mainstay of treatment for ADHD, not all adults respond optimally to, or can tolerate, these medicines...
October 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28930260/association-between-auricular-signals-and-the-risk-factors-of-metabolic-syndrome
#20
Lorna Kwai Ping Suen, Chao Hsing Yeh, Simon Kai Wang Yeung, Jojo Yee Mei Kwan, Hon Fat Wong, David Chan, Alice Siu Ping Cheung, Vincent Tok Fai Yeung
Objective: This study aims to determine the association between auricular signals and the risk factors of metabolic syndrome (MS). Methods: A case-control study with an equal number of cases and controls matched by age group and gender was conducted. A total of 204 participants were recruited. Patients were verified as having MS based on the International Diabetes Federation (IDF) criteria. Auricular assessment was conducted in the following sequence: visual inspection, electrical skin resistance test (ESRT), and pressure pain test (PPT)...
June 25, 2017: Medicines (Basel, Switzerland)
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