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https://www.readbyqxmd.com/read/29343283/the-classroom-communication-resource-ccr-intervention-to-change-peer-s-attitudes-towards-children-who-stutter-cws-study-protocol-for-a-randomised-controlled-trial
#1
Rizwana Mallick, Harsha Kathard, Lehana Thabane, Mershen Pillay
BACKGROUND: Children who stutter (CWS) are at a high-risk of being teased and bullied in primary school because of negative peer attitudes and perceptions towards stuttering. There is little evidence to determine if classroom-based interventions are effective in changing peer attitudes towards stuttering. The primary objective is to determine the effect of the Classroom Communication Resource (CCR) intervention versus usual practice, measured using the Stuttering Resource Outcomes Measure (SROM) 6-months post-intervention among grade 7 students...
January 17, 2018: Trials
https://www.readbyqxmd.com/read/29338314/inflammatory-cytokines-in-the-papillary-tips-and-urine-of-nephrolithiasis-patients
#2
Andrew Yang Sun, Bryan Hinck, Benjamin R Cohen, Karen Keslar, Robert L Fairchild, Manoj Monga
INTRODUCTION: Intrarenal inflammation has been implicated in the pathogenesis of nephrolithiasis, with prior work showing increased urine levels of IL-6, IL-8, and CCL-2 in stone patients. However, no studies have assessed for inflammation in the renal papillae. We sought to characterize novel papillary tip and urinary biomarkers in stone patients. METHODS: 92 patients with nephrolithiasis undergoing percutaneous nephrolithotomy were enrolled. Papillary tip biopsies, kidney urine, and bladder urine were collected, as well as voided urine from 8 healthy volunteers...
January 16, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29334608/factors-associated-with-prolonged-patient-attributable-delay-in-the-diagnosis-of-colorectal-cancer
#3
Irene Zarcos-Pedrinaci, Teresa Téllez, Francisco Rivas-Ruiz, María Del Carmen Padilla-Ruiz, Julia Alcaide, Antonio Rueda, María Luisa Baré, María Manuela Morales Suárez-Varela, Eduardo Briones, Cristina Sarasqueta, Nerea Fernández-Larrea, Antonio Escobar, José María Quintana, Maximino Redondo
Purpose: The delayed diagnosis of colorectal cancer (CRC) may be attributable to sociodemographic characteristics, to aspects of tumour histopathology or to the functioning of the health system. We seek to determine which of these factors most influences prolonged patient-attributable delay (PPAD) in the diagnosis and treatment of CRC. Materials and method: A prospective, multicentre observational study was conducted in 22 Spanish hospitals. In total, 1,785 patients were recruited to the study between 2010 and 2012 and underwent elective or urgent surgery...
January 2, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29334275/laparoscopic-ovarian-drilling-versus-gnrh-antagonist-combined-with-cabergoline-as-a-prophylaxis-against-the-re-development-of-ovarian-hyperstimulation-syndrome
#4
Emaduldin Seyam, Enas Hefzy
OBJECTIVE: The aim of this work was to investigate the value of laparoscopic ovarian drilling (LOD) compared with GnRH antagonist flexible protocol combined with cabergoline (Cb), as a prophylaxis against the re-development of ovarian hyperstimulation syndrome (OHSS) in women with clomiphene citrate-resistant polycystic ovary disease (CCR-PCOD) who had severe OHSS before in a previous ICSI cycle. STUDY DESIGN: It is a prospective controlled study, where 250 CCR-PCOD women (n = 250) with a history of severe OHSS before, had been recruited for the study...
January 15, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29329933/combined-hepatic-and-pulmonary-metastasectomies-from-colorectal-carcinoma-data-from-the-prospective-spanish-registry-2008-2010
#5
Jose R Jarabo, Ana M Gómez, Joaquín Calatayud, Carlos A Fraile, Elena Fernández, Nuria Pajuelo, Raul Embún, Laureano Molins, Juan J Rivas, Florentino Hernando
INTRODUCTION: Resection of both liver and lung metastases from colorectal carcinoma (CRC) is a standard of care in selected patients with oligometastatic disease. We present here the analysis of the subgroup of patients undergoing combined surgery from the Spanish Group of Surgery of Pulmonary Metastases (PM) from Colorectal Carcinoma (GECMP-CCR-SEPAR). METHODS: We analyze characteristics, survival and prognostic factors of patients undergoing combined resection from March-2008 to February-2010 and followed-up during at least 3 years, from the prospective multicenter Spanish Registry...
January 9, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29325765/a-systematic-investigation-on-the-composition-evolution-and-expression-characteristics-of-chemokine-superfamily-in-grass-carp-ctenopharyngodon-idella
#6
Zhiwei Liao, Quanyuan Wan, Xun Xiao, Jianfei Ji, Jianguo Su
Chemokines are a superfamily of small cytokines and characterized based on their ability to induce directional migration of cells along a concentration gradient by binding to chemokine receptors, which have important roles in immunology and development. Due to the numerous and diverse members, systematic identifications of chemokine superfamily genes are difficult in many species. To that end, a comprehensive analysis of BLAST and scripting language was conducted to systematically identify and characterize chemokine system in grass carp (Ctenopharyngodon idella)...
January 8, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29325686/phase-ii-study-of-tailored-s-1-monotherapy-with-a-1-week-interval-after-a-2-week-dosing-period-in-elderly-patients-with-advanced-non-small-cell-lung-cancer
#7
Hisatsugu Goto, Yoshio Okano, Hisanori Machida, Nobuo Hatakeyama, Fumitaka Ogushi, Takashi Haku, Takanori Kanematsu, Tomoyuki Urata, Soji Kakiuchi, Masaki Hanibuchi, Saburo Sone, Yasuhiko Nishioka
BACKGROUND: S-1 is an oral fluoropyrimidine that is active in the treatment of non-small cell lung cancer (NSCLC); however, an optimal treatment schedule and appropriate dose adjustments of S-1 in elderly patients have not yet been established. METHODS: We conducted a phase II trial to evaluate the efficacy and safety of a 2-week S-1 monotherapy treatment followed by a 1-week interval as a first-line treatment of elderly NSCLC patients, by adjusting the dose based on the individual creatinine clearance (Ccr) and body surface area (BSA)...
January 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29319128/the-preliminary-study-on-expression-and-clinical-value-of-platelet-derived-growth-factor-bb-hypoxia-inducible-factor-1%C3%AE-and-c-c-motif-chemokine-receptor-2-in-the-peripheral-blood-during-the-pathogenesis-of-graves-disease
#8
Ying Liu, Jinglan Tang, Qiaohong Hu, Kefeng Lu, Chunjie Hou
Backgroud: Platelet-derived growth factor BB (PDGF-BB) plays an important role in the development of GD(Graves' disease). However, it is still unknown whether PDGF-BB is expressed in peripheral blood and whether the expression of PDGF-BB contributes to GD. We aim to study the expression of PDGF-BB, Hypoxia inducible factor(HIF)-1α and C-C motif chemokine receptor(CCR)-2 in peripheral blood of patients with GD and explore its effect and potential mechanism in pathogenesis. METHODS: 41 patients with GD (GD group) and 45 healthy people(control group) were chosen...
January 10, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29301319/application-of-near-infrared-reflectance-spectroscopy-for-rapid-and-non-destructive-discrimination-of-hulled-barley-naked-barley-and-wheat-contaminated-with-fusarium
#9
Jongguk Lim, Giyoung Kim, Changyeun Mo, Kyoungmin Oh, Geonseob Kim, Hyeonheui Ham, Seongmin Kim, Moon S Kim
Fusarium is a common fungal disease in grains that reduces the yield of barley and wheat. In this study, a near infrared reflectance spectroscopic technique was used with a statistical prediction model to rapidly and non-destructively discriminate grain samples contaminated with Fusarium. Reflectance spectra were acquired from hulled barley, naked barley, and wheat samples contaminated with Fusarium using near infrared reflectance (NIR) spectroscopy with a wavelength range of 1175-2170 nm. After measurement, the samples were cultured in a medium to discriminate contaminated samples...
January 2, 2018: Sensors
https://www.readbyqxmd.com/read/29299798/mild-renal-dysfunction-defined-by-creatinine-clearance-rate-has-limited-impact-on-clinical-outcomes-after-allogeneic-hematopoietic-stem-cell-transplantation
#10
Shuntaro Ikegawa, Ken-Ichi Matsuoka, Tomoko Inomata, Naoto Ikeda, Hiroyuki Sugiura, Taiga Kuroi, Takeru Asano, Shohei Yoshida, Hisakazu Nishimori, Nobuharu Fujii, Eisei Kondo, Yoshinobu Maeda, Mitsune Tanimoto
Creatinine clearance rate (Ccr) is a more accurate indicator of renal function than serum creatinine. Data are sparse regarding the prognostic value of renal impairment calculated using Ccr in patients who undergo allogeneic hematopoietic stem cell transplantation (allo-HSCT). We performed a retrospective analysis of 185 patients who underwent allo-HSCT. These patients were divided into two groups by Ccr (ml/min) before transplantation; one showed normal renal function (Ccr ≥ 60, n = 156) and the other showed mild renal dysfunction (30 ≤ Ccr < 60, n = 29), and transplant outcomes were compared between the groups...
January 4, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29295552/carbon-catabolite-repression-in-filamentous-fungi
#11
REVIEW
Muhammad Adnan, Wenhui Zheng, Waqar Islam, Muhammad Arif, Yakubu Saddeeq Abubakar, Zonghua Wang, Guodong Lu
Carbon Catabolite Repression (CCR) has fascinated scientists and researchers around the globe for the past few decades. This important mechanism allows preferential utilization of an energy-efficient and readily available carbon source over relatively less easily accessible carbon sources. This mechanism helps microorganisms to obtain maximum amount of glucose in order to keep pace with their metabolism. Microorganisms assimilate glucose and highly favorable sugars before switching to less-favored sources of carbon such as organic acids and alcohols...
December 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29280303/dual-ccr2-5-antagonist-attenuates-obesity-induced-insulin-resistance-by-regulating-macrophage-recruitment-and-m1-m2-status
#12
Ji Hye Huh, Hong Min Kim, Eun Soo Lee, Mi Hye Kwon, Bo Ra Lee, Hyun-Jeong Ko, Choon Hee Chung
OBJECTIVE: Adipose tissue inflammation induced by macrophage infiltration through the C-C motif chemokine receptor (CCR) 2 or CCR5 pathway has a pivotal role in obesity-related disease and insulin resistance. Here, the effect of PF4178903, a dual CCR2/CCR5 antagonist, on obesity and insulin resistance was evaluated. METHODS: Forty male C57BL/6J mice were divided into four groups as follows: (1) regular diet (RD), (2) RD with PF4178903, (3) high-fat diet (HFD), and (4) HFD with PF4178903...
December 27, 2017: Obesity
https://www.readbyqxmd.com/read/29278442/sevelamer-hydrochloride-suppresses-proliferation-of-parathyroid-cells-during-the-early-phase-of-chronic-renal-failure-in-rats
#13
Xiao Xiao, Yan Liu, Xiaoshi Zhong, Daoyuan Zhou, Xuan Xiong
AIM: We examined the effects of sevelamer on parathyroid cell proliferation and secondary hyperparathyroidism in rats following induction of early-phase early phase of chronic renal failure (CRF) by unilateral ureteral obstruction (UUO). METHODS: For 5 days, rats in the control group received normal food, rats in the sevelamer group (SH) received control food plus 5% sevelamer, and rats in the low protein group (LP) received low protein food. Five rats of each group were sacrificed at baseline (d0)...
December 26, 2017: Nephrology
https://www.readbyqxmd.com/read/29277225/the-quantification-of-free-amadori-compounds-and-amino-acids-allows-to-model-the-bound-maillard-reaction-products-formation-in-soybean-products
#14
Antonio Dario Troise, Markus Wiltafsky, Vincenzo Fogliano, Paola Vitaglione
The quantification of protein bound Maillard reaction products (MRPs) is still a challenge in food chemistry. Protein hydrolysis is the bottleneck step: it is time consuming and the protein degradation is not always complete. In this study, the quantitation of free amino acids and Amadori products (APs) was compared to the percentage of blocked lysine by using chemometric tools. Eighty thermally treated soybean samples were analyzed by mass spectrometry to measure the concentration of free amino acids, free APs and the protein-bound markers of the Maillard reaction (furosine, Nε-(carboxymethyl)-l-lysine, Nε-(carboxyethyl)-l-lysine, total lysine)...
May 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29248311/a-cost-effectiveness-analysis-of-contact-x-ray-brachytherapy-for-the-treatment-of-patients-with-rectal-cancer-following-a-partial-response-to-chemoradiotherapy
#15
C Rao, F M Smith, A P Martin, A S Dhadda, A Stewart, S Gollins, B Collins, T Athanasiou, A Sun Myint
AIMS: Following chemoradiotherapy in patients with rectal cancer, the addition of contact X-ray brachytherapy (CXB) in partial responders might increase the proportion of patients with a clinical complete response (cCR) and who are thus suitable for watch and wait management. However, the long-term cost-effectiveness of this approach has not been evaluated. MATERIALS AND METHODS: Decision analytical modelling and a Markov simulation were used to compare long-term costs, quality-adjusted life years (QALYs) and cost-effectiveness from a third-party payer (National Health Service) perspective for treatment strategies after chemoradiotherapy; watch and wait with CXB when a cCR was not initially achieved after external beam radiotherapy (EBRT) (WWCXB), watch and wait with EBRT alone (WWEBRT) and radical surgery for all patients...
December 13, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29244864/resistant-and-susceptible-responses-in-alfalfa-medicago-sativa-to-bacterial-stem-blight-caused-by-pseudomonas-syringae-pv-syringae
#16
Lev G Nemchinov, Jonathan Shao, Maya N Lee, Olga A Postnikova, Deborah A Samac
Bacterial stem blight caused by Pseudomonas syringae pv. syringae is a common disease of alfalfa (Medicago sativa L). Little is known about host-pathogen interactions and host defense mechanisms. Here, individual resistant and susceptible plants were selected from cultivars Maverick and ZG9830 and used for transcript profiling at 24 and 72 hours after inoculation (hai) with the isolate PssALF3. Bioinformatic analysis revealed a number of differentially expressed genes (DEGs) in resistant and susceptible genotypes...
2017: PloS One
https://www.readbyqxmd.com/read/29244160/interplay-between-the-catabolite-repression-control-protein-crc-hfq-and-rna-in-hfq-dependent-translational-regulation-in-pseudomonas-aeruginosa
#17
Elisabeth Sonnleitner, Alexander Wulf, Sébastien Campagne, Xue-Yuan Pei, Michael T Wolfinger, Giada Forlani, Konstantin Prindl, Laetitia Abdou, Armin Resch, Frederic H-T Allain, Ben F Luisi, Henning Urlaub, Udo Bläsi
In Pseudomonas aeruginosa the RNA chaperone Hfq and the catabolite repression control protein (Crc) act as post-transcriptional regulators during carbon catabolite repression (CCR). In this regard Crc is required for full-fledged Hfq-mediated translational repression of catabolic genes. RNAseq based transcriptome analyses revealed a significant overlap between the Crc and Hfq regulons, which in conjunction with genetic data supported a concerted action of both proteins. Biochemical and biophysical approaches further suggest that Crc and Hfq form an assembly in the presence of RNAs containing A-rich motifs, and that Crc interacts with both, Hfq and RNA...
December 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29241450/azacitidine-improves-clinical-outcomes-in-older-patients-with-acute-myeloid-leukaemia-with-myelodysplasia-related-changes-compared-with-conventional-care-regimens
#18
John F Seymour, Hartmut Döhner, Aleksandra Butrym, Agnieszka Wierzbowska, Dominik Selleslag, Jun Ho Jang, Rajat Kumar, James Cavenagh, Andre C Schuh, Anna Candoni, Christian Récher, Irwindeep Sandhu, Teresa Bernal Del Castillo, Haifa Kathrin Al-Ali, Jose Falantes, Richard M Stone, Mark D Minden, Jerry Weaver, Steve Songer, C L Beach, Hervé Dombret
BACKGROUND: Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes (AML-MRC) are generally older and more likely to have poor-risk cytogenetics, leading to poor response and prognosis. More than one-half of all older (≥65 years) patients in the phase 3 AZA-AML-001 trial had newly diagnosed AML-MRC. METHODS: We compared clinical outcomes for patients with AML-MRC treated with azacitidine or conventional care regimens (CCR; induction chemotherapy, low-dose cytarabine, or supportive care only) overall and within patient subgroups defined by cytogenetic risk (intermediate or poor) and age (65-74 years or ≥75 years)...
December 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29234106/first-demonstration-of-coherent-cherenkov-radiation-matched-to-circular-plane-wave
#19
Norihiro Sei, Toshiharu Takahashi
We observed coherent Cherenkov radiation matched to a circular plane wave (CCR-MCP) for the first time using a hollow conical dielectric made of a high-density polyethylene. The refractive index and the absorption coefficient of the dielectric were evaluated to be 1.537 ± 0.004 and 0.006 ± 0.028 by measuring the pulse formed by the interference between the CCR-MCP and the coherent diffraction radiation. These values were consistent with the values shown in a reference for the high-density polyethylene...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29232989/impact-of-cataract-on-health-related-quality-of-life-in-a-longitudinal-japanese-chronic-obstructive-pulmonary-cohort
#20
Hidehiro Irie, Shotaro Chubachi, Minako Sato, Mamoru Sasaki, Naofumi Kameyama, Takashi Inoue, Yoshitaka Oyamada, Hidetoshi Nakamura, Koichiro Asano, Tomoko Betsuyaku
Cigarette smoking increases the risk of developing both cataract and chronic obstructive pulmonary disease (COPD). The prevalence of cataract and the clinical characteristics of COPD patients with cataract were retrospectively investigated in a 2-year observational COPD cohort. We analyzed 395 patients with complete data on ophthalmologic evaluation (319 subjects with COPD and 76 subjects at risk of COPD). There was no difference in the prevalence of cataract between COPD patients and those at risk (47.0% vs...
January 1, 2017: Chronic Respiratory Disease
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