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https://www.readbyqxmd.com/read/28921876/validation-of-artificial-neural-networks-as-a-methodology-for-donor-recipient-matching-for-liver-transplantation
#1
María Dolores Ayllón, Rubén Ciria, Manuel Cruz-Ramírez, María Pérez-Ortiz, Roberto Valente, John O'Grady, Manuel de la Mata, César Hervás-Martínez, Nigel D Heaton, Javier Briceño
BACKGROUND: In 2014, we reported a model for Donor-Recipient matching (D-R) in liver transplantation (LT) based on artificial-neural-networks (ANN) from a Spanish multicentre study (MADR-E: Model for Allocation of Donor and Recipient in España). The aim is to test the ANN-based methodology in a different European-healthcare system in order to validate it. METHODS: An ANN model was designed using a cohort of patients from King's College Hospital (KCH) (N=822). The ANN was trained and tested using KCH pairs for both 3- and 12-months survival models...
September 16, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28915263/universal-representations-of-evaporation-modes-in-sessile-droplets
#2
Angkur Jyoti Dipanka Shaikeea, Saptarshi Basu, Abhishek Tyagi, Saksham Sharma, Rishabh Hans, Lalit Bansal
In this work, we provide a simple method to represent the contact line dynamics of an evaporating sessile droplet. As a droplet evaporates, two distinct contact line dynamics are observed. They are collectively known as modes of evaporation, namely Constant Contact Radius (CCR) and Constant Contact Angle (CCA). Another intermediate mode-Stick-Slide (SS) or mixed mode is also commonly observed. In this article, we are able to provide a graphical representation to these modes (named as MOE plot), which is visually more comprehensive especially for comparative studies...
2017: PloS One
https://www.readbyqxmd.com/read/28910571/factors-that-influence-tear-meniscus-area-and-conjunctivochalasis-the-singapore-indian-eye-study
#3
Stanley Poh, Ryan Lee, Jennifer Gao, Carin Tan, Preeti Gupta, Charumathi Sabanayagam, Ching-Yu Cheng, Tien-Yin Wong, Louis Tong
PURPOSE: Assessment of tear film and conjunctiva is critical to define presence and severity of ocular surface disease. We aimed to characterize tear meniscus area (TMA) and conjunctivochalasis by anterior segment optical coherence tomography (ASOCT) in population-based patients and identify potential factors associated with low TMA and severe conjunctivochalasis. METHODS: Study subjects were enrolled from The Singapore Indian Eye Study, a population-based study of Asian Indian in Singapore...
September 14, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28895027/the-aging-urban-brain-analyzing-outdoor-physical-activity-using-the-emotiv-affectiv-suite-in-older-people
#4
Chris Neale, Peter Aspinall, Jenny Roe, Sara Tilley, Panagiotis Mavros, Steve Cinderby, Richard Coyne, Neil Thin, Gary Bennett, Catharine Ward Thompson
This research directly assesses older people's neural activation in response to a changing urban environment while walking, as measured by electroencephalography (EEG). The study builds on previous research that shows changes in cortical activity while moving through different urban settings. The current study extends this methodology to explore previously unstudied outcomes in older people aged 65 years or more (n = 95). Participants were recruited to walk one of six scenarios pairing urban busy (a commercial street with traffic), urban quiet (a residential street) and urban green (a public park) spaces in a counterbalanced design, wearing a mobile Emotiv EEG headset to record real-time neural responses to place...
September 11, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28889198/polyhydroxyalkanoate-production-from-sucrose-by-cupriavidus-necator-strains-harboring-csc-genes-from-escherichia-coli-w
#5
Hisashi Arikawa, Keiji Matsumoto, Tetsuya Fujiki
Cupriavidus necator H16 is the most promising bacterium for industrial production of polyhydroxyalkanoates (PHAs) because of their remarkable ability to accumulate them in the cells. With genetic modifications, this bacterium can produce poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx), which has better physical properties, as well as poly(3-hydroxybutyrate) (PHB) using plant oils and sugars as a carbon source. Considering production cost, sucrose is a very attractive raw material because it is inexpensive; however, this bacterium cannot assimilate sucrose...
September 9, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28878860/draft-genome-sequences-of-two-opportunistic-pathogenic-strains-of-staphylococcus-cohnii-isolated-from-human-patients
#6
Soraya Mendoza-Olazarán, José F Garcia-Mazcorro, Rayo Morfín-Otero, Licet Villarreal-Treviño, Adrián Camacho-Ortiz, Eduardo Rodríguez-Noriega, Paola Bocanegra-Ibarias, Héctor J Maldonado-Garza, Scot E Dowd, Elvira Garza-González
Herein, we report the draft-genome sequences and annotation of two opportunistic pathogenic strains of Staphylococcus cohnii isolated from humans. One strain (SC-57) was isolated from blood from a male patient in May 2006 and the other (SC-532) from a catheter from a male patient in June 2006. Similar to other genomes of Staphylococcus species, most genes (42%) of both strains are involved in metabolism of amino acids and derivatives, carbohydrates and proteins. Eighty (4%) genes are involved in virulence, disease, and defense and both species show phenotypic low biofilm production and evidence of increased antibiotic resistance associated to biofilm production...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/28878823/a-de-novo-complex-chromosome-rearrangement-associated-with-multisystematic-abnormalities-a-case-report
#7
Chan Tian, Dan Li, Ping Liu, Liping Jiao, Xuefeng Gao, Jie Qiao
BACKGROUND: Complex chromosomal rearrangements (CCRs) are constitutional structural rearrangements that involve three or more chromosomes or that have more than two breakpoints. CASE PRESENTATION: Here, we describe a four-way CCR involving chromosomes 4, 5, 6 and 8. The patient had mild multisystematic abnormalities during his development, including defects in his eyes and teeth, exomphalos and asthenozoospermia. His wife had two spontaneous abortions during the first trimester...
2017: Molecular Cytogenetics
https://www.readbyqxmd.com/read/28878232/holographic-writing-of-ink-based-phase-conjugate-nanostructures-via-laser-ablation
#8
Muhammad Waqas Khalid, Rajib Ahmed, Ali K Yetisen, Bader AlQattan, Haider Butt
The optical phase conjugation (OPC) through photonic nanostructures in coherent optics involves the utilization of a nonlinear optical mechanism through real-time processing of electromagnetic fields. Their applications include spectroscopy, optical tomography, wavefront sensing, and imaging. The development of functional and personalized holographic devices in the visible and near-infrared spectrum can be improved by introducing cost-effective, rapid, and high-throughput fabrication techniques and low-cost recording media...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28875388/intrinsic-renal-cells-induce-lymphocytosis-of-th22-cells-from-iga-nephropathy-patients-through-b7-ctla-4-and-ccl-ccr-pathways
#9
Lu Gan, Qiaoling Zhou, Xiaozhao Li, Chen Chen, Ting Meng, Jiaxi Pu, Mengyuan Zhu, Chenggen Xiao
IgA nephropathy (IgAN), the most common glomerulonephritis, has an unclear pathogenesis. The role of Th22 cells, which are intimately related to proteinuria and progression in IgAN, in mediating infection-related IgAN is unclear. This study aimed to characterize the association between intrinsic renal cells (tubular epithelial cells and mesangial cells) and Th22 cells in immune regulation of infection-related IgAN and to elucidate the impact of Th22 lymphocytosis; the proinflammatory cytokines IL-1, IL-6, and TNF-α; and CCL chemokines on kidney fibrosis...
September 5, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28872742/association-between-social-support-functional-status-and-change-in-health-related-quality-of-life-and-changes-in-anxiety-and-depression-in-colorectal-cancer-patients
#10
REVIEW
M Gonzalez-Saenz de Tejada, A Bilbao, M Baré, E Briones, C Sarasqueta, J M Quintana, A Escobar
OBJECTIVE: The aim of this study was to explore the association between baseline social support, functional status, and change in health-related quality of life (HRQoL) in colorectal cancer patients and change in anxiety and depression measured by Hospital Anxiety and Depression Scale (HADS) at 1 year after surgery. METHODS: Consecutive patients who were due to undergo therapeutic surgery for the first time for colon or rectal cancer in 9 hospitals in Spain were eligible for the study...
September 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28864727/immuno-oncology-clinical-trial-design-limitations-challenges-and-opportunities
#11
EDITORIAL
Christina S Baik, Eric H Rubin, Patrick M Forde, Janice M Mehnert, Deborah Collyar, Marcus O Butler, Erica L Dixon, Laura Q M Chow
Recent advances in immuno-oncology and regulatory approvals have been rapid and paradigm shifting in many difficult-to-treat malignancies. Despite immune checkpoint inhibitor therapy becoming the standard of care across multiple tumor types, there are many unanswered questions that need to be addressed before this therapeutic modality can be fully harnessed. Areas of limitations include treatment of patients not sufficiently represented in clinical trials, uncertainty of the optimal treatment dosing and duration, and lack of understanding regarding long-term immune related toxicities and atypical tumor responses...
September 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28864726/from-famine-to-feast-developing-early-phase-combination-immunotherapy-trials-wisely
#12
EDITORIAL
Daphne Day, Arta M Monjazeb, Elad Sharon, S Percy Ivy, Eric H Rubin, Gary L Rosner, Marcus O Butler
Not until the turn of this century has immunotherapy become a fundamental component of cancer treatment. While monotherapy with immune modulators, such as immune checkpoint inhibitors, provides a subset of patients with durable clinical benefit and possible cure, combination therapy offers the potential for antitumor activity in a greater number of patients. The field of immunology has provided us with a plethora of potential molecules and pathways to target. This abundance makes it impractical to empirically test all possible combinations efficiently...
September 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28864725/the-challenge-for-development-of-valuable-immuno-oncology-biomarkers
#13
EDITORIAL
Janice M Mehnert, Arta M Monjazeb, Johanna M T Beerthuijzen, Deborah Collyar, Larry Rubinstein, Lyndsay N Harris
The development of immunotherapy is an important breakthrough for the treatment of cancer, with antitumor efficacy observed in a wide variety of tumors. To optimize immunotherapy use, approaches must be developed to identify which patients are likely to achieve benefit. To minimize therapeutic toxicities and costs, understanding the ideal choice and sequencing of the numerous immuno-oncology agents available for individual patients is thus critical, but fraught with challenges. The immune tumor microenvironment (TME) is a unique aspect of the response to immuno-oncology agents and measurement of single biomarkers does not adequately capture these complex interactions...
September 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28864724/immuno-oncology-trial-endpoints-capturing-clinically-meaningful-activity
#14
EDITORIAL
Valsamo Anagnostou, Mark Yarchoan, Aaron R Hansen, Hao Wang, Franco Verde, Elad Sharon, Deborah Collyar, Laura Q M Chow, Patrick M Forde
Immuno-oncology (I-O) has required a shift in the established paradigm of toxicity and response assessment in clinical research. The design and interpretation of cancer clinical trials has been primarily driven by conventional toxicity and efficacy patterns observed with chemotherapy and targeted agents, which are insufficient to fully inform clinical trial design and guide therapeutic decisions in I-O. Responses to immune-targeted agents follow nonlinear dose-response and dose-toxicity kinetics mandating the development of novel response evaluation criteria...
September 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28864723/challenges-and-opportunities-in-adapting-clinical-trial-design-for-immunotherapies
#15
EDITORIAL
Lillian L Siu, S Percy Ivy, Erica L Dixon, Amy E Gravell, Steven A Reeves, Gary L Rosner
Immunotherapy adds an exciting new dimension to the treatment of cancer, joining other approaches as a key pillar in the oncotherapeutics armamentarium. Immuno-oncology agents harbor unique mechanisms of antitumor activity by leveraging the host immune system, which may result in response patterns, resistance kinetics, and toxicity profiles that differ from other systemic therapies. These features have led to many discussions on ways to optimally integrate immunotherapy into cancer clinical trials. This overview provides an introduction to the four CCR Focus articles that ensue, with special thoughts paid to clinical trial endpoints, biomarker development and validation, combination strategies, and limitations that arise with increasing use of these agents...
September 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28855199/prevalence-and-associated-factors-of-diabetic-retinopathy-in-beijing-china-a-cross-sectional-study
#16
Jing Cui, Ji-Ping Ren, Dong-Ning Chen, Zhong Xin, Ming-Xia Yuan, Jie Xu, Qi-Sheng You, Jin-Kui Yang
OBJECTIVES: The study aimed to determine the exact risk factors for diabetic retinopathy (DR) in the Chinese population using a cohort of 17  985 individuals from Beijing, China. DESIGN: Cross-sectional study. SETTING: A hospital. PARTICIPANTS: 17  985 individuals from Beijing, China. PRIMARY AND SECONDARY OUTCOME MEASURES: This was a cross-sectional study of permanent residents from the Changping area (Beijing, China) recruited from July 2010 to March 2011 and from March 2014 to February 2015 during a routine health examination at the Tongren Hospital of Beijing...
August 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28845522/adipochemokines-induced-by-ultraviolet-irradiation-contribute-to-impaired-fat-metabolism-in-subcutaneous-fat-cells
#17
E J Kim, Y K Kim, S Kim, J E Kim, Y D Tian, E J Doh, D H Lee, J H Chung
BACKGROUND: Adipose tissue is now appreciated as the pivotal regulator of metabolic and endocrine functions. Subcutaneous (SC) fat, in contrast to visceral fat, may protect against metabolic syndrome and systemic inflammation. We demonstrated that chronic as well as acute UV exposure to the skin induces loss of underlying SC fat. UV-irradiated SC fat may produce chemokines or cytokines which modulate lipid homeostasis and secretion of adipokines. OBJECTIVES: We aim to elucidate UV-induced specific adipochemokines implicated in UV-induced modulation of SC fat...
August 27, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28845432/interaction-between-corneal-and-internal-ocular-aberrations-induced-by-orthokeratology-and-its-influential-factors
#18
Qingzhong Chen, Min Li, Ying Yuan, Rao Me, Yunjie Yu, Guangsen Shi, Bilian Ke
PURPOSE: To investigate the interaction between corneal, internal, and total wavefront aberrations (WAs) and their influential factors during orthokeratology (OK) treatment in Chinese adolescents. METHODS: Thirty teenagers (n = 30 eyes) were enrolled in the study; spherical equivalent refraction (SE), corneal curvature radius (CCR), central corneal thickness (CCT), WAs, and the difference in limbal transverse diameter and OK lens diameter (ΔLLD) were detected before and after one-month OK treatment...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28844294/cervical-spine-collar-removal-by-emergency-room-nurses-a-quality-improvement-project
#19
Guillaume Fontaine, Massimo Forgione, Francis Lusignan, Marc-André Lanoue, Simon Drouin
INTRODUCTION: The Canadian C-Spine Rule (CCR) is a clinical decision aid to facilitate the safe removal of cervical collars in the alert, orientated, low-risk adult trauma patient. Few health care settings have assessed initiatives to train charge nurses to use the CCR. This practice improvement project conducted in a secondary trauma center in Canada aimed to (1) train charge nurses of the emergency room to use the CCR, (2) monitor its use throughout the project period, and (3) compare the assessments of the charge nurses with those of emergency physicians...
August 22, 2017: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/28843571/selection-of-robust-variables-for-transfer-of-classification-models-employing-the-successive-projections-algorithm
#20
Karla Danielle Tavares Melo Milanez, Thiago César Araújo Nóbrega, Danielle Silva Nascimento, Roberto Kawakami Harrop Galvão, Márcio José Coelho Pontes
Multivariate models have been widely used in analytical problems involving quantitative and qualitative analyzes. However, there are cases in which a model is not applicable to spectra of samples obtained under new experimental conditions or in an instrument not involved in the modeling step. A solution to this problem is the transfer of multivariate models, usually performed using standardization of the spectral responses or enhancement of the robustness of the model. This present paper proposes two new criteria for selection of robust variables for classification transfer employing the successive projections algorithm (SPA)...
September 1, 2017: Analytica Chimica Acta
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