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https://www.readbyqxmd.com/read/27909797/wd40-repeat-protein-mocrec-is-essential-for-carbon-repression-and-is-involved-in-conidiation-growth-and-pathogenicity-of-magnaporthe-oryzae
#1
Khalid Abdelkarim Omer Matar, Xiaofeng Chen, Dongjie Chen, Wilfred Mabeche Anjago, Justice Norvienyeku, Yahong Lin, Meilian Chen, Zonghua Wang, Daniel J Ebbole, Guo-Dong Lu
Carbon catabolite repression (CCR) is a common regulatory mechanism used by microorganisms to prioritize use of a preferred carbon source (usually glucose). The CreC WD40-repeat protein is a major component of the CCR pathway in Aspergillus nidulans. To clarify the function of the CreC ortholog from Magnaporthe oryzae in regulating gene expression important for pathogenesis, MoCreC was identified and genetically characterized. The vegetative growth rate of the MoCreC deletion mutant on various carbon sources was reduced...
December 1, 2016: Current Genetics
https://www.readbyqxmd.com/read/27895382/non-invasive-measurement-of-melanin-derived-radicals-in-living-mouse-tail-using-x-band-epr
#2
Yukihiro Ogawa, Megumi Ueno, Emiko Sekine-Suzuki, Ikuo Nakanishi, Ken-Ichiro Matsumoto, Shingo Fujisaki
The aim of this experiment is to measure in vivo generation of melanin-derived radicals non-invasively, as a quantifiable index of radio-biological effect. Melanin-derived radicals in a living intact mouse tail tip were non-invasively measured in very simple way using an X-band electron paramagnetic resonance spectrometer. Colored mouse strains, C57BL/6NCr, BDF1, and C3H/He, have clear EPR signal corresponding to melanin-derived radicals in the tail tip; however, albino mouse strains, BALB/cCr, ddY, ICR, have no EPR signals...
November 2016: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/27888636/factors-that-influence-treatment-delay-in-patients-with-colorectal-cancer
#3
Irene Zarcos-Pedrinaci, Alberto Fernández-López, Teresa Téllez, Francisco Rivas-Ruiz, Antonio Rueda A, María Manuela Morales Suarez-Varela, Eduardo Briones, Marisa Baré, Antonio Escobar, Cristina Sarasqueta, Nerea Fernández de Larrea, Urko Aguirre, José María Quintana, Maximino Redondo, On Behalf Of The Caress-Ccr Study Group
A prospective study was performed of patients diagnosed with colorectal cancer (CRC), distinguishing between colonic and rectal location, to determine the factors that may provoke a delay in the first treatment (DFT) provided.2749 patients diagnosed with CRC were studied. The study population was recruited between June 2010 and December 2012. DFT is defined as time elapsed between diagnosis and first treatment exceeding 30 days.Excessive treatment delay was recorded in 65.5% of the cases, and was more prevalent among rectal cancer patients...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27886861/applicability-of-the-japanese-equation-for-estimating-glomerular-filtration-rate-in-patients-with-advanced-stage-thoracic-cancer
#4
Takashi Kikuchi, Hiroaki Akamatsu, Keita Mori, Ayaka Tanaka, Kuninobu Kanai, Atsushi Hayata, Nahomi Tokudome, Keiichiro Akamatsu, Yasuhiro Koh, Masanori Nakanishi, Hiroki Ueda, Nobuyuki Yamamoto
BACKGROUND: The 24-h creatinine clearance (24-h Ccr) and the Cockcroft-Gault equation (CG) are commonly used as markers of renal function in clinical practice. However, the utility of the Japanese equation for estimating glomerular filtration rate (eGFR) in cancer patients has not yet been evaluated. The aim of this cross-sectional study was to investigate the extent and correlating factors for differences between eGFR and both 24-h Ccr and CG in advanced-stage thoracic cancer patients...
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27885479/wait-and-see-approach-for-rectal-cancer-with-a-clinically-complete-response-after-neoadjuvant-concurrent-chemoradiotherapy
#5
Hyun Jung Kim, Jin Ho Song, Hyeong Sik Ahn, Bong-Hoi Choi, Hojin Jeong, Hoon Sik Choi, Yun Hee Lee, Ki Mun Kang, Bae Kwon Jeong
PURPOSE: Rectal cancer patients with a pathological complete response (pCR) after neoadjuvant concurrent chemoradiotherapy (CCRT) have a better prognosis compared to those without a pCR. Therefore, the "Wait and See" (W&S) approach in those who achieved clinically complete response (cCR) after CCRT was introduced as an alternative modality to the total mesorectal excision (TME). The aim of this study was to compare the oncological outcomes between W&S and TME via meta-analysis. METHODS: We performed a comprehensive literature search on January 14, 2016, using MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science, and Scopus...
November 24, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27882431/diagnostic-value-of-conventional-chest-radiography-in-intrathoracic-goiters-retrospective-analysis-of-2570-patients
#6
Fares Benmiloud, Michel Grino, Charles Oliver, Anne Denizot
PURPOSE: Since intrathoracic goiters (IG), either cervico-mediastinal goiters (CMGs) or mediastinal nodules (MNs), can lead to sternotomies and/or evitable reoperations, their detection is mandatory before thyroid surgery. A systematic screening by CT scan or MRI is not conceivable because of their expensiveness. We tested if conventional chest radiography (CCR) could remain a good screening tool for IG before thyroid surgery. METHODS: In this retrospective study (2554 patients), CCR usefulness was evaluated in relation with patients' complaints, clinical examination, neck US, and anatomical and surgical findings...
November 24, 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/27881973/livestock-associated-methicillin-resistant-staphylococcus-aureus-la-mrsa-clonal-complex-cc-398-isolated-from-uk-animals-belong-to-european-lineages
#7
Meenaxi Sharma, Javier Nunez-Garcia, Angela M Kearns, Michel Doumith, Patrick R Butaye, M Angeles Argudín, Angela Lahuerta-Marin, Bruno Pichon, Manal AbuOun, Jon Rogers, Richard J Ellis, Christopher Teale, Muna F Anjum
In recent years, there has been an increase in the number of livestock-associated methicillin resistant Staphylococcus aureus (LA-MRSA) clonal complex (CC) 398 recovered from S. aureus isolated animals in the UK. To determine possible origins of 12 LA-MRSA CC398 isolates collected after screening more than a thousand S. aureus animal isolates from the UK between 2013 and 2015, whole genome sequences (WGS) of CC398 European, including UK, and non-European isolates from diverse animal hosts were compared. Phylogenetic reconstruction applied to WGS data to assess genetic relatedness of all 89 isolates, clustered the 12 UK CC398 LA-MRSA within the European sub-lineages, although on different nodes; implicating multiple independent incursions into the UK, as opposed to a single introduction followed by clonal expansion...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27878893/survival-outcomes-of-consolidation-chemoradiotherapy-in-esophageal-cancer-patients-who-achieve-clinical-complete-response-but-refuse-surgery-after-neoadjuvant-chemoradiotherapy
#8
Hsin-Yueh Fang, Yin-Kai Chao, Hsien-Kun Chang, Chen-Kan Tseng, Yun-Hen Liu
Some esophageal cancer patients may be reluctant to accept the scheduled resection after neoadjuvant chemoradiotherapy (nCRT) because of its potential negative impact on quality of life as a result of high morbidity. This study was performed to investigate the survival outcomes of these patients. Between 2000 and 2012, we identified 190 patients with resectable esophageal squamous cell carcinoma (ESCC) who did not proceed to surgery following nCRT. Subjects who had a clinical complete response (cCR) and were medically fit for surgery were deemed eligible...
November 23, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27869542/treatment-challenge-of-a-non-toxic-cyanobacterium-romeria-elegans-bloom-event-in-a-south-australian-wastewater-treatment-plant-a-case-study
#9
Radisti A Praptiwi, Carlos J Pestana, Emma T Sawade, Nick Swain, Gretchen Schroeder, Gayle Newcombe
A bloom of the non-toxic cyanobacterium Romeria elegans in waste stabilisation ponds within Angaston waste water treatment plant (WWTP) has posed an unprecedented treatment challenge for the local water utility. The water from the stabilisation ponds is chlorinated for safety prior to reuse on nearby farmland. Cyanobacteria concentrations of approximately 1.2×10(6) cells mL(-1) increased the chlorine demand dramatically. Operators continuously increased the disinfectant dose up to 50 mg L(-1) to achieve operational guideline values for combined chlorine (0...
November 21, 2016: Environmental Technology
https://www.readbyqxmd.com/read/27859879/association-between-social-support-functional-status-and-change-in-health-related-quality-of-life-and-changes-in-anxiety-and-depression-in-colorectal-cancer-patients
#10
REVIEW
M Gonzalez-Saenz de Tejada, A Bilbao, M Baré, E Briones, C Sarasqueta, J M Quintana, A Escobar
OBJECTIVE: The aim of this study was to explore the association between baseline social support, functional status and change in HRQoL in colorectal cancer patients and change in anxiety and depression measured by HADS at one year post-surgery. METHODS: Consecutive patients who were due to undergo therapeutic surgery for the first time for colon or rectal cancer in nine hospitals in Spain were eligible for the study. Patients completed the following questionnaires prior to surgery and 12 months afterwards: one HRQoL instrument, the EORTC QLQ-C30; a social support questionnaire, the Duke-UNC Functional Social Support Questionnaire; the Barthel Index, to assess functional status; the Hospital Anxiety and Depression Scale (HADS), to assess anxiety and depression; as well as questions about sociodemographic information...
November 8, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27842904/yield-of-computed-tomography-of-the-cervical-spine-in-cases-of-simple-assault
#11
Matthew L Uriell, Jason W Allen, Brendan P Lovasik, Marc D Benayoun, Robert M Spandorfer, Chad A Holder
BACKGROUND: Computed tomography (CT) of the cervical spine (C-spine) is routinely ordered for low-impact, non-penetrating or "simple" assault at our institution and others. Common clinical decision tools for C-spine imaging in the setting of trauma include the National Emergency X-Radiography Utilization Study (NEXUS) and the Canadian Cervical Spine Rule for Radiography (CCR). While NEXUS and CCR have served to decrease the amount of unnecessary imaging of the C-spine, overutilization of CT is still of concern...
October 29, 2016: Injury
https://www.readbyqxmd.com/read/27836596/arm-microcontroller-based-portable-nitrite-electrochemical-analyzer-using-cytochrome-c-reductase-biofunctionalized-onto-screen-printed-carbon-electrode
#12
Paulraj Santharaman, Krishna Arun Venkatesh, Kanagavel Vairamani, Alby Robson Benjamin, Niroj K Sethy, Kalpana Bhargava, Chandran Karunakaran
Nitrite (NO2(-)) supplementation limits hypoxia-induced oxidative stress and activates the alternate NO pathway which may partially account for the nitrite-mediated cardioprotection. So, sensitive and selective biosensors with point-of-care devices need to be explored to detect the physiological nitrite level due to its important role in human pathophysiology. In this work, cytochrome c reductase (CcR) biofunctionalized self assembled monolayer (SAM) functionalized on gold nanoparticles (GNPs) in polypyrrole (PPy) nanocomposite onto the screen printed carbon electrode (SPCE) was investigated as a biosensor for the detection of nitrite based on its electrochemical and catalytic properties...
October 19, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27829010/interval-of-uncertainty-an-alternative-approach-for-the-determination-of-decision-thresholds-with-an-illustrative-application-for-the-prediction-of-prostate-cancer
#13
Johannes A Landsheer
Often, for medical decisions based on test scores, a single decision threshold is determined and the test results are dichotomized into positive and negative diagnoses. It is therefore important to identify the decision threshold with the least number of misclassifications. The proposed method uses trichotomization: it defines an Uncertain Interval around the point of intersection between the two distributions of individuals with and without the targeted disease. In this Uncertain Interval the diagnoses are intermixed and the numbers of correct and incorrect diagnoses are (almost) equal...
2016: PloS One
https://www.readbyqxmd.com/read/27822158/using-the-journal-bmj-case-reports-to-promote-the-publication-of-clinical-case-reports
#14
Blanca San José Montano
OBJECTIVE: The study updates and enhances clinicians' knowledge about clinical case reports (CCRs) and encourages publication of such articles. METHODS: The author developed and offered a session about BMJ Case Reports to medical and surgical departments in the University Hospital of Móstoles. The session reviewed the contents and add-on services of the journal, conventional and alternative indicators of journal quality, use of CCRs to share valuable clinical lessons, and manuscript preparation and submission...
October 2016: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/27819140/de-novo-balanced-complex-chromosome-rearrangements-involving-chromosomes-1b-and-3b-of-wheat-and-1r-of-rye
#15
Tianheng Ren, Zhi Li, Benju Yan, Feiquan Tan, Zongxiang Tang, Shulan Fu, Manyu Yang, Zhenglong Ren
Complex chromosome rearrangements (CCRs) are defined as structural abnormalities involving more than two chromosome breaks, coupled with exchanges of chromosomal segments. Information on CCRs in plants is limited. In the present study, a plant (26-4) harboring translocation chromosomes 1RS.1BL and 4RS.4DL was selected from a double monosomic (1R and 4R) addition line, which was derived from the hybrid between wheat cultivar MY11 and a Chinese local rye variety. The genome of the plant with double alien translocation chromosomes in the monosomic form showed more instability than that harboring a single translocation...
August 23, 2016: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/27806504/measuring-the-effect-of-size-on-technical-efficiency-of-the-united-arab-emirates-hospitals
#16
Ashraf Mahate, Samer Hamidi, Fevzi Akinci
OBJECTIVE: The main purpose of this study is to estimate the technical efficiency of the United Arab Emirates (UAE) hospitals and examine the effect of hospital size on estimated technical efficiency scores. METHODS: Using 2012 data from Ministry of Health, Dubai Health Authority, and Health Authority in Abu Dhabi, we employed a nonparametric method, data envelopment analysis (DEA), to estimate the technical efficiency of 96 private and governmental hospitals in the UAE...
July 12, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27778459/infliximab-is-equivalently-suppressing-oxidative-stress-compared-to-tocilizumab-among-well-controlled-patients-with-rheumatoid-arthritis
#17
Kazuha Kizaki, Fumiharu Yamashita, Tomoya Hayashi, Noboru Funakoshi
AIM: This study was designed to investigate which biological agent, infliximab or tocilizumab, would more intensively keep suppressing oxidative stress among well-controlled patients as C-reactive protein (CRP) levels normalized in rheumatoid arthritis (RA). In addition, it was intended to clarify indicative factors of oxidative stress among well-controlled patients with RA. METHODS: We recruited 61 well-controlled (CRP < 0.3 mg/dL within normal ranges) patients with RA using biological agents (infliximab n = 33; tocilizumab n = 28), active RA patients with CRP > 1...
October 24, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/27778266/therapeutic-role-of-tangshenkang-granule-in-rat-model-with-diabetic-nephropathy
#18
Shun-Jin Hu, Bing Shu, Hua Jin, Xiao-Feng Li, Jia-Rong Mao, Ke-Jun Ren, Lei Gao, Li Yang, You-Wan Wu, Yong-Jun Wang
OBJECTIVE: To evaluate the renal protective effect of Tangshenkang Granule () in a rat model of diabetic nephropathy (DN). METHODS: Forty male Sprague-Dawley rats were randomly divided into control, DN, Tangshenkang and benazepril groups. DN model was established in the rats of DN, Tangshenkang and benazepril groups. Tangshenkang Granule solution and benazepril hydrochloride solution were intragastrically administered daily to the rats in the Tangshenkang and benazepril groups for 8 weeks, respectively...
October 24, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27761796/molecular-cloning-characterization-and-expression-analysis-of-lignin-genes-from-sugarcane-genotypes-varying-in-lignin-content
#19
Lakshmi Kasirajan, Kalaivaani Aruchamy, Prathima P Thirugnanasambandam, Selvi Athiappan
Sugarcane (Saccharum spp.) is one of the highest biomass-producing plant and the best lignocellulosic feedstock for ethanol production. To achieve more efficient conversion of biomass to ethanol, a better understanding of the main factors affecting biomass recalcitrance is needed. Therefore, with this objective, here, we report a systematic study on lignin content, deposition, identification, and cloning of genes involved in lignin biosynthesis and their differential expression in five sugarcane clones, EC11003, EC11010, IK 76-91, IK 76-99, and Co 86032...
October 19, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27761714/advantages-of-laparoscopic-compared-to-conventional-surgery-are-not-related-to-an-innate-immune-response-of-peritoneal-immune-activation-an-animal-study-in-rats
#20
Philipp Lingohr, Jonas Dohmen, Hanno Matthaei, Timo Schwandt, Kathy Stein, Gun-Soo Hong, Julia Steitz, Thomas Longerich, Edwin Bölke, Sven Wehner, Jörg C Kalff
PURPOSE: Laparoscopic surgery (LS) has proved superior compared to conventional surgery (CS) regarding morbidity, length of hospital stay, rate of wound infection and time until recovery. An improved preservation of the postoperative immune function is assumed to contribute to these benefits though the role of the local peritoneal immune response is still poorly understood. Our study investigates the peritoneal immune response subsequent to abdominal surgery and compares it between laparoscopic and conventional surgery to find an immunological explanation for the clinically proven benefits of LS...
October 19, 2016: Langenbeck's Archives of Surgery
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