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https://www.readbyqxmd.com/read/28097501/efficient-production-of-free-fatty-acids-from-ionic-liquid-based-acid-or-enzyme-catalyzed-bamboo-hydrolysate
#1
Le Mi, Dandan Qin, Jie Cheng, Dan Wang, Sha Li, Xuetuan Wei
Two engineered Escherichia coli strains, DQ101 (MG1655 fadD (-))/pDQTES and DQ101 (MG1655 fadD (-))/pDQTESZ were constructed to investigate the free fatty acid production using ionic liquid-based acid- or enzyme-catalyzed bamboo hydrolysate as carbon source in this study. The plasmid, pDQTES, carrying an acyl-ACP thioesterase 'TesA of E. coli in pTrc99A was constructed firstly, and then (3R)-hydroxyacyl-ACP dehydratase was ligated after the TesA to give the plasmid pDQTESZ. These two strains exhibited efficient fatty acid production when glucose was used as the sole carbon source, with a final concentration of 2...
January 17, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28096844/influence-of-an-extended-education-program-on-the-knowledge-of-cardiovascular-risk-factors-among-subjects-undergoing-rehabilitation-following-acute-coronary-syndrome
#2
Wojciech S Kapko, Łukasz J Krzych
INTRODUCTION: Health education is a component of complex cardiac rehabilitation (CCR). AIM: To evaluate the influence of an authorial extended educational program on the knowledge of cardiovascular risk factors among subjects undergoing early in-hospital rehabilitation following acute coronary syndrome treated with percutaneous intervention. MATERIAL AND METHODS: This prospective study covered 205 consecutive subjects (153 men and 52 women, aged 62 ±9 years) undergoing CCR...
December 2016: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28090488/excellent-outcome-of-medical-treatment-for-kasabach-merritt-syndrome-a-single-center-experience
#3
Jin Ah Kim, Young Bae Choi, Eun Sang Yi, Ji Won Lee, Ki Woong Sung, Hong Hoe Koo, Keon Hee Yoo
BACKGROUND: Kasabach-Merritt syndrome (KMS) is a rare but life-threatening illness. The purpose of this study is to report our single-center experience with KMS. METHODS: We reviewed the medical records of 13 patients who were diagnosed with KMS between 1997 and 2012 at Samsung Medical Center. Treatment response was defined as follows: 1) hematologic complete response (HCR) - platelet count >130×10(9)/L without transfusion; 2) clinical complete response (CCR) - complete tumor disappearance or small residual vascular tumor displaying lack of proliferation for at least 6 months after treatment discontinuation...
December 2016: Blood Research
https://www.readbyqxmd.com/read/28086793/methicillin-resistance-and-virulence-genes-in-invasive-and-nasal-staphylococcus-epidermidis-isolates-from-neonates
#4
Vivian Carolina Salgueiro, Natalia Lopes Pontes Iorio, Marcelle Cristina Ferreira, Raiane Cardoso Chamon, Kátia Regina Netto Dos Santos
BACKGROUND: Staphylococcus epidermidis is an opportunistic pathogen involved in hospital-acquired infections, particularly in those related to medical devices. This study characterized 50 genetically unrelated S. epidermidis isolates from bloodstream infections (BSIs, n = 31) and nares (n = 19) of neonates in relation to staphylococcal chromosomal cassette mec (SCCmec) type, biofilm production and associated genes, and the arginine catabolic mobile elements (ACME), in order to detect virulence factors that could discriminate a potential invasiveness isolate or predict an increasing pathogenicity...
January 13, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28074152/optimal-dosage-of-cefmetazole-for-intraoperative-antimicrobial-prophylaxis-in-patients-undergoing-surgery-for-colorectal-cancer
#5
Atsushi Tomizawa, Takatoshi Nakamura, Toshiaki Komatsu, Hiroshi Inano, Rumiko Kondo, Masahiko Watanabe, Koichiro Atsuda
BACKGROUND: Few studies have reported the dosage of cefmetazole (CMZ) for intraoperative antimicrobial prophylaxis in patients underwent surgery for colorectal cancer. We therefore examined the optimal intraoperative dosage of CMZ according to pharmacokinetic/pharmacodynamic (PK/PD) theory in patients who undergoing surgery for colorectal cancer. METHODS: The study group comprised 23 patients with colorectal cancer who underwent surgery, using CMZ as antimicrobial treatment to prevent postoperative infection...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28057910/arthroscopic-detection-of-medial-meniscal-injury-in-small-breed-dogs-with-the-use-of-a-joint-distractor
#6
Joo-Ho Kim, Su-Young Heo, Hae-Beom Lee
The goal of the present study was to evaluate the diagnostic value of a joint distractor in arthroscopy in small-breed dogs. Sixty stifle joints, which were collected from thirty cadavers, were used in this study. To simulate different injuries, no medial meniscal tear, a full-thickness vertical longitudinal tear, a partial-thickness vertical longitudinal tear, full- and partial-thickness vertical longitudinal tears, or a peripheral detachment were made on the caudal horn of the medial meniscus of each stifle joint along with cranial cruciate ligament (CrCL) rupture...
January 4, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28050651/primary-transoral-robotic-surgery-with-concurrent-neck-dissection-for-early-stage-oropharyngeal-squamous-cell-carcinoma-implemented-at-a-danish-head-and-neck-cancer-center-a-phase-ii-trial-on-feasibility-and-tumour-margin-status
#7
Niclas Rubek, Hani Ibrahim Channir, Birgitte Wittenborg Charabi, Christel Bræmer Lajer, Katalin Kiss, Hans Ulrik Nielsen, Jens Bentzen, Jeppe Friborg, Christian von Buchwald
There is an increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) in the western world due to human papillomavirus (HPV). According to the Danish Head and Neck Cancer Group guidelines, the current recommended treatment of patients with OPSCC in Denmark is primary radiation therapy (RT) with or without concomitant chemotherapy. This is the first study in Scandinavia from a head and neck cancer centre that aims to demonstrate the feasibility of performing primary transoral robotic surgery (TORS) and concurrent neck dissection for patients with early stage OPSCC...
January 3, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28046757/mo-de-207b-04-impact-of-reconstruction-field-of-view-on-radiomics-features-in-computed-tomography-ct-using-a-texture-phantom
#8
M Shafiq Ul Hassan, G Zhang, K Latifi, J Oliver, D Hunt, R Guzman, Y Balagurunathan, D Mackin, L Court, R Gillies, E Moros
PURPOSE: To investigate the impact of reconstruction Field of View on Radiomics features in computed tomography (CT) using a texture phantom. METHODS: A rectangular Credence Cartridge Radiomics (CCR) phantom, composed of 10 different cartridges, was scanned on four different CT scanners from two manufacturers. A pre-defined scanning protocol was adopted for consistency. The slice thickness and reconstruction interval of 1.5 mm was used on all scanners. The reconstruction FOV was varied to result a voxel size ranging from 0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045072/induced-pluripotent-stem-cell-generation-from-a-man-carrying-a-complex-chromosomal-rearrangement-as-a-genetic-model-for-infertility-studies
#9
Aurélie Mouka, Vincent Izard, Gérard Tachdjian, Sophie Brisset, Frank Yates, Anne Mayeur, Loïc Drévillon, Rafika Jarray, Philippe Leboulch, Leila Maouche-Chrétien, Lucie Tosca
Despite progress in human reproductive biology, the cause of male infertility often remains unknown, due to the lack of appropriate and convenient in vitro models of meiosis. Induced pluripotent stem cells (iPSCs) derived from the cells of infertile patients could provide a gold standard model for generating primordial germ cells and studying their development and the process of spermatogenesis. We report the characterization of a complex chromosomal rearrangement (CCR) in an azoospermic patient, and the successful generation of specific-iPSCs from PBMC-derived erythroblasts...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28043160/validation-of-a-dynamic-measure-of-current-cognitive-reserve-in-a-longitudinally-assessed-sample-of-healthy-older-adults
#10
Mathew J Summers, Megan E Thow, David D Ward, Nichole L Saunders, Shannon Z Klekociuk, Abbie-Rose Imlach, Jeffery J Summers, James C Vickers
Cognitive reserve (CR) is a theoretical construct describing the underlying cognitive capacity of an individual that confers differential levels of resistance to, and recovery from, brain injuries of various types. To date, estimates of an individual's level of CR have been based on single proxy measures that are retrospective and static in nature. To develop a measure of dynamic change in CR across a lifetime, we previously identified a latent factor, derived from an exploratory factor analysis of a large sample of healthy older adults, as current CR (cCR)...
January 1, 2017: Assessment
https://www.readbyqxmd.com/read/28040464/metabolic-engineering-of-clostridium-tyrobutyricum-for-enhanced-butyric-acid-production-from-glucose-and-xylose
#11
Hongxin Fu, Le Yu, Meng Lin, Jufang Wang, Zhilong Xiu, Shang-Tian Yang
Clostridium tyrobutyricum is a promising microorganism for butyric acid production. However, its ability to utilize xylose, the second most abundant sugar found in lignocellulosic biomass, is severely impaired by glucose-mediated carbon catabolite repression (CCR). In this study, CCR in C. tyrobutyricum was eliminated by overexpressing three heterologous xylose catabolism genes (xylT, xylA and xlyB) cloned from C. acetobutylicum. Compared to the parental strain, the engineered strain Ct-pTBA produced more butyric acid (37...
December 28, 2016: Metabolic Engineering
https://www.readbyqxmd.com/read/28039808/analysis-of-amino-acid-and-monoamine-neurotransmitters-and-their-metabolites-in-rat-urine-of-alzheimer-s-disease-using-in-situ-ultrasound-assisted-derivatization-dispersive-liquid-liquid-microextraction-with-uhplc-ms-ms
#12
Xian-En Zhao, Yongrui He, Meng Li, Guang Chen, Na Wei, Xiao Wang, Jing Sun, Shuyun Zhu, Jinmao You
Neurotransmitters (NTs) may play an important role in neurodegenerative disorders such as Alzheimer's disease (AD). In order to investigate the potential links, a new simple, fast, accurate and sensitive analytical method, based on in situ ultrasound-assisted derivatization dispersive liquid-liquid microextraction (in situ UA-DDLLME) coupled with ultra high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS), has been developed and validated. The quantitation of amino acid neurotransmitters (AANTs) and monoamine neurotransmitters (MANTs) in urine of AD rats were performed in this work...
December 26, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28029303/e1308-phase-ii-trial-of-induction-chemotherapy-followed-by-reduced-dose-radiation-and-weekly-cetuximab-in-patients-with-hpv-associated-resectable-squamous-cell-carcinoma-of-the-oropharynx-ecog-acrin-cancer-research-group
#13
Shanthi Marur, Shuli Li, Anthony J Cmelak, Maura L Gillison, Weiqiang J Zhao, Robert L Ferris, William H Westra, Jill Gilbert, Julie E Bauman, Lynne I Wagner, David R Trevarthen, Jahagirdar Balkrishna, Barbara A Murphy, Nishant Agrawal, A Dimitrios Colevas, Christine H Chung, Barbara Burtness
Purpose Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is treatment-responsive. Definitive chemoradiation results in high cure rates but causes long-term toxicity and may represent overtreatment of some patients. This phase II trial evaluated whether complete clinical response (cCR) to induction chemotherapy (IC) could select patients with HPV-associated OPSCC for reduced radiation dose as a means of sparing late sequelae. Methods Patients with HPV16 and/or p16-positive, stage III-IV OPSCC received three cycles of IC with cisplatin, paclitaxel, and cetuximab...
December 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28027515/organ-or-sphincter-preservation-for-rectal-cancer-the-role-of-contact-x-ray-brachytherapy-in-a-monocentric-series-of-112-patients
#14
Anne Claire Frin, Ludovic Evesque, Jocelyn Gal, Karène Benezery, Eric François, Jean Gugenheim, Emmanuel Benizri, Yan Château, Serge Marcié, Jérome Doyen, Jean-Pierre Gérard
BACKGROUND: Contact X-ray brachytherapy (CXB) has been used at Centre Antoine Lacassagne since 2002 to increase the chance of conservative treatment (organ or sphincter preservation) in rectal cancer. A consecutive series of 112 patients (pts) is reported. METHODS: Three protocols were used in selected rectal adenocarcinomas. Group 1: T1 N0 treated with local excision (LE) followed by adjuvant CXB. Group 2: T2 or 'early' T3 N0 treated with CXB combined with chemoradiotherapy (CRT) followed by surveillance or LE...
December 24, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/28008457/arterial-hypertension-treated-with-angiotensin-converting-enzyme-inhibitors-and-glucocorticoids-are-independent-risk-factors-associated-with-decreased-glomerular-filtration-rate-in-systemic-sclerosis
#15
Predrag Ostojic, Natasa Stojanovski
The aim of this study was to estimate prevalence and severity of renal insufficiency in systemic sclerosis (SSc) and to assess risk factors associated with reduced glomerular filtration rate (GFR) in SSc patients. Seventy-three consecutive patients with SSc (67 women and 6 men), mean age 56.2 years, mean disease duration 6.7 years, were included in this cross-sectional study. GFR was measured by creatinine clearance (CCr) in all patients, as well as 24-h proteinuria. We assessed frequency and severity of renal insufficiency in our patients with SSc and estimated the association of renal insufficiency with age, disease duration, subtype of the disease, earlier diagnosed arterial hypertension, and medications for which we assumed to affect renal function-cytostatics, nonsteroidal anti-inflammatory drugs, glucocorticoids, ACE inhibitors, diuretics, and calcium channel blockers (CCB)...
December 22, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27990558/comparative-proteomic-analysis-of-hemolymph-from-uninfected-and-candidatus-liberibacter-asiaticus-infected-diaphorina-citri
#16
T A Gill, C Chu, K S Pelz-Stelinski
Hemolymph was characterized from Diaphorina citri adults infected with the phytopathogen, Candidatus Liberibacter asiaticus (CLas), and compared with that from uninfected psyllids. This study identified 5531 and 3220 peptides within infected and uninfected hemolymph using nano-LC-MS/MS. A reduced number of proteins were detected for D. citri and all known endosymbionts within infected hemolymph as compared to uninfected hemolymph. A large number of immune defense proteins were absent from D. citri hemolymph; however, a single recognition protein (PGRP), two serine protease inhibitors, three prophenoloxidase (proPO) enzymes, and a single serine protease in an uninfected D...
December 19, 2016: Amino Acids
https://www.readbyqxmd.com/read/27956488/structural-and-biochemical-characterization-of-cinnamoyl-coa-reductases
#17
Steven A Sattler, Alexander M Walker, Wilfred Vermerris, Scott E Sattler, ChulHee Kang
Cinnamoyl-CoA reductase (CCR) catalyzes the reduction of hydroxycinnamoyl-CoA esters using NADPH to produce hydroxycinnamyl aldehyde precursors in lignin synthesis. The catalytic mechanism and substrate specificity of cinnamoyl-CoA reducases from Sorghum bicolor, a strategic plant for the bioenergy production, were deduced from crystal structures, site-directed mutagenesis, and kinetic and thermodynamic analyses. Although SbCCR1 displayed higher affinity for caffeoyl-CoA or p-coumaroyl-CoA than for feruloyl-CoA, the enzyme showed significantly higher activity for the latter substrate...
December 12, 2016: Plant Physiology
https://www.readbyqxmd.com/read/27936044/comparison-of-reef-fish-survey-data-gathered-by-open-and-closed-circuit-scuba-divers-reveals-differences-in-areas-with-higher-fishing-pressure
#18
Andrew E Gray, Ivor D Williams, Kostantinos A Stamoulis, Raymond C Boland, Kevin C Lino, Brian B Hauk, Jason C Leonard, John J Rooney, Jacob M Asher, Keolohilani H Lopes, Randall K Kosaki
Visual survey by divers using open-circuit (OC) SCUBA is the most widely used approach to survey coral reef fishes. Therefore, it is important to quantify sources of bias in OC surveys, such as the possibility that avoidance of OC divers by fishes can lead to undercounting in areas where targeted species have come to associate divers with a risk of being speared. One potential way to reduce diver avoidance is to utilize closed circuit rebreathers (CCRs), which do not produce the noise and bubbles that are a major source of disturbance associated with OC diving...
2016: PloS One
https://www.readbyqxmd.com/read/27932553/normalization-matters-tracking-the-best-strategy-for-sperm-mirna-quantification
#19
Celia Corral-Vazquez, Joan Blanco, Albert Salas-Huetos, Francesca Vidal, Ester Anton
STUDY QUESTION: What is the most reliable normalization strategy for sperm microRNA (miRNA) quantitative Reverse Transcription Polymerase Chain Reactions (qRT-PCR) using singleplex assays? SUMMARY ANSWER: The use of the average expression of hsa-miR-100-5p and hsa-miR-30a-5p as sperm miRNA qRT-PCR data normalizer is suggested as an optimal strategy. WHAT IS KNOWN ALREADY: Mean-centering methods are the most reliable normalization strategies for miRNA high-throughput expression analyses...
December 8, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27931292/circulating-follicular-t-helper-cell-subset-distribution-in-patients-with-asthma
#20
Fang Gong, Chunyan Qian, HuaYan Zhu, Jie Zhu, Yuhong Pan, QiaoJing Dong, DongLin Jiang
BACKGROUND: The pathogenesis of allergic asthma is primarily characterized by abnormality in the immunoglobulin E (IgE) pathway, suggesting a possible role for follicular T-helper cells (Tfh) in the genesis of excessive IgE accumulation. The blood chemokine (C-X-C motif) receptor 5 (CXCR5)+CD4+ T cells, known as circulating Tfh, share common functional characteristics with Tfh cells from germinal centers. There are three subsets of circulating Tfh cells: Tfh1 (CXCR3+CC chemokine receptor [CCR] 6), Tfh2 (CXCR3CCR6) and Tfh17 (CXCR3CCR6+)...
November 2016: Allergy and Asthma Proceedings:
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