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Toenail fungus

Hari Pankaj Vanam, P Narsimha Rao, Kalyani Mohanram, Prakash Peralam Yegneswaran, Shiva Prakash Mandya Rudramurthy
The genus Tritirachium is a mitosporic fungus which inhabits in soil and decaying plant material and also a notable insect pathogen. Human infections with Tritirachium species though rare were previously reported to cause corneal ulcers, otomycosis, onychomycosis, and dermatomycosis of the scalp and hence may be considered as a potential pathogen. Here we report a case of distal lateral subungual onychomycosis involving right great toenail in a 22-year-old female, wherein direct potassium hydroxide preparations, fungal cultures, and molecular sequencing of the isolate established Tritirachium oryzae as the etiological agent...
April 2018: Mycopathologia
Antonio Zalacain, Alejandra Merlos, Elena Planell, Erica G Cantadori, Teresa Vinuesa, Miguel Viñas
Onychomycoses are fungal infections of the fingernails or toenails having a prevalence of 3% among adults and accounts for 50% of nail infections. It is caused by dermatophytes, non-dermatophyte filamentous fungi, and yeasts. Compressions and microtraumas significantly contribute to onychomycosis. Laser and photodynamic therapies are being proposed to treat onychomycosis. Laser light (1064 nm) was used to treat onychomycosis in 156 affected toenails. Patients were clinically followed up for 9 months after treatment...
May 2018: Lasers in Medical Science
Marvlyn Eba, Anna Longdoh Njunda, Rene Njikam Mouliom, Emmanuel Tebit Kwenti, Anold Nsoh Fuh, Gordon Takop Nchanji, Julius Atashili
BACKGROUND: Onychomycosis is an infection of the nail unit by a fungus. This is a very common infection amongst diabetics. Its occurrence among diabetics in Fako division is unknown. In this study we provide information on the characteristics of onychomycosis in diabetics in Fako division, Cameroon. METHODS: A cross-sectional descriptive and analytical hospital-based study was conducted in two diabetic clinics in the Buea and Limbe regional hospitals. We recruited 152 consenting diabetics into the study...
November 22, 2016: BMC Research Notes
Yasemin Oz, Iman Qoraan, Ali Oz, Ilknur Balta
BACKGROUND: Diabetes patients are particularly susceptible to fungal infections because their vascular and immunological systems are compromised. OBJECTIVES: The present study aimed to determine prevalences of tinea pedis and onychomycosis, factors predisposing to their development, and antifungal susceptibilities of causative fungal species against fluconazole, itraconazole, and terbinafine in patients with type 2 diabetes mellitus (DM). METHODS: Study groups were defined according to hemoglobin A1C rates of ≥6...
January 2017: International Journal of Dermatology
Chi-Ching Tsang, Teresa W S Hui, Kim-Chung Lee, Jonathan H K Chen, Antonio H Y Ngan, Emily W T Tam, Jasper F W Chan, Andrea L Wu, Mei Cheung, Brian P H Tse, Alan K L Wu, Christopher K C Lai, Dominic N C Tsang, Tak-Lun Que, Ching-Wan Lam, Kwok-Yung Yuen, Susanna K P Lau, Patrick C Y Woo
Thirteen Aspergillus isolates recovered from nails of 13 patients (fingernails, n=2; toenails, n=11) with onychomycosis were characterized. Twelve strains were identified by multilocus sequencing as Aspergillus spp. (Aspergillus sydowii [n=4], Aspergillus welwitschiae [n=3], Aspergillus terreus [n=2], Aspergillus flavus [n=1], Aspergillus tubingensis [n=1], and Aspergillus unguis [n=1]). Isolates of A. terreus, A. flavus, and A. unguis were also identifiable by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry...
February 2016: Diagnostic Microbiology and Infectious Disease
Vit Hubka, Christoffer V Nissen, Rasmus Hare Jensen, Maiken C Arendrup, Adela Cmokova, Alena Kubatova, Magdalena Skorepova, Miroslav Kolarik
Trichophyton onychocola is a recently described geophilic dermatophyte that has been isolated from a toenail of Czech patient with a history of onychomycosis due to T. rubrum and clinical suspicion of relapse. In this study, we report a similar case from Denmark in an otherwise healthy 56-year-old man. The patient had a history of great toenail infection caused by T. rubrum in 2004 and presented with suspected relapse in 2011 and 2013. Trichophyton onychocola was the only microbial agent isolated at the second visit in 2013 and the identification was confirmed by DNA sequencing...
November 2015: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
M Soltani, A R Khosravi, H Shokri, A Sharifzadeh, A Balal
OBJECTIVE: To determine the incidence of onychomycosis based on age and sex, morphological pattern of the disease, predisposing factors and identification of fungus by direct microscopy and culture methods. METHODS: A prospective study was conducted on 140 patients with nail disorders. A detailed history and thorough examination was done in all patients. The samples were taken from patients clinically suspected of fingernails and toenails infections attending a dermatology center in Tehran, Iran...
June 2015: Journal de Mycologie Médicale
Pravesh Yadav, Archana Singal, Deepika Pandhi, Shukla Das
INTRODUCTION: There is a constant need to define the epidemiological and mycological characteristics of onychomycosis (OM) for optimal management strategies. OBJECTIVES: To define the epidemiological and mycological characteristics of patients with dermatophyte toenail OM in a tertiary care hospital. MATERIALS AND METHODS: Hundred consecutive patients of KOH and culture-positive dermatophyte toenail OM were subjected to detailed history, clinical examination and investigations...
March 2015: Indian Journal of Dermatology
S Nouripour-Sisakht, H Mirhendi, M R Shidfar, B Ahmadi, A Rezaei-Matehkolaei, M Geramishoar, F Zarei, N Jalalizand
BACKGROUND: Onychomycosis is a common nail infection caused by dermatophytes, non-dermatophyte molds (NDM), and yeasts. Aspergillus species are emerging as increasing causes of toenail onychomycosis. The purpose of this study was species delineation of Aspergillus spp. isolated from patients with onychomycosis. METHODS: During a period of one year (2012-2013), nail samples were collected from patients clinically suspected of onychomycosis and subjected to microscopic examination and culture...
June 2015: Journal de Mycologie Médicale
Yuka Miura, Kimie Takehara, Gojiro Nakagami, Ayumi Amemiya, Toshiki Kanazawa, Nao Kimura, Chihiro Kishi, Yuiko Koyano, Nao Tamai, Tetsuro Nakamura, Makoto Kawashima, Yuichiro Tsunemi, Hiromi Sanada
AIM: The purpose of the present study was to assess the difference in foot temperature between tinea unguium-positive older adults with subungual hyperkeratosis and tinea unguium-negative older adults with subungual hyperkeratosis to develop a temperature-based screening method for tinea unguium. METHODS: The present cross-sectional, observational study investigated 51 residents with subungual hyperkeratosis in two facilities covered by long-term care insurance between October 2011 and December 2011...
August 2015: Geriatrics & Gerontology International
Thomas Jansen
No abstract text is available yet for this article.
September 11, 2014: MMW Fortschritte der Medizin
Yasushi Suga, Utako Kimura, Masataro Hiruma
Onychomycosis is a common disease seen in dermatology practice. Most patients with onychomycosis opt for treatment due to the social stigma attached to the unsightly appearance, as well as the pain that can at times make walking difficult. However, in many cases, onychomycosis is resistant to oral antifungal medication, which is the first-line therapy for this disease. In recent years, we have attempted a new treatment method using a long-pulsed 1,064nm Nd :YAG laser (Cutera Inc., Brisbane, CA, USA) in refractory cases with onychomycosis...
2014: Medical Mycology Journal
B Sigurgeirsson, R Baran
BACKGROUND: Onychomycosis is a common disorder, and high prevalence figures are commonly cited in the literature. OBJECTIVES: Evaluate the prevalence of onychomycosis based on published studies. METHODS: Relevant studies were identified in Medline by using specific search criteria. RESULTS: Eleven population-based and 21 hospital-based studies were identified. The mean prevalence in Europe and North America was 4.3% [95% Confidence Interval (CI): 1...
November 2014: Journal of the European Academy of Dermatology and Venereology: JEADV
Boni E Elewski, Phoebe Rich, Antonella Tosti, David M Pariser, Richard Scher, Ralph C Daniel, Aditya K Gupta
Onychomycosis is a fungal infection of the nail unit, more common in toenails than in fingernails, and caused by a variety of fungi including dermatophytes, nondermatophyte molds, and <em>Candida.</em> There are 4 to 5 subtypes related to the method of fungal invasion of the nail unit, the most common being distal lateral subungual onychomycosis. Here the fungus enters the distal lateral part of the nail bed, the region of the hyponychium, often as an extension of tinea pedis. Hyperkeratosis occurs under the nail plate, resulting in detachment of the nail plate from the nail bed (onycholysis), with subungual thickening...
July 1, 2013: Journal of Drugs in Dermatology: JDD
Dong Min Kim, Myung Hoon Lee, Moo Kyu Suh, Gyoung Yim Ha, Heesoo Kim, Jong Soo Choi
Onychomycosis is usually caused by dermatophytes, but some nondermatophytic molds and yeasts are also associated with invasion of nails. The genus Chaetomium is a dematiaceous nondermatophytic mold found in soil and plant debris as a saprophytic fungus. We report the first Korean case of onychomycosis caused by Chaetomium globosum in a 35-year-old male. The patient showed brownish-yellow discoloration and subungual hyperkeratosis on the right toenails (1st and 5th) and left toenails (1st and 4th). Direct microscopic examination of scraping on the potassium hydroxide preparation revealed septate hyphae and repeated cultures on Sabouraud's dextrose agar (SDA) without cycloheximide slants showed the same fast-growing colonies, which were initially velvety white then turned to dark gray to brown...
May 2013: Annals of Dermatology
Flávia Maria Lamb, Cheila Denise Ottonelli Stopiglia, Gerson Vetoratto, João Carlos Goldani, Maria Lúcia Scroferneker
Onychomycosis is one of the most frequent infections affecting the fingernails or the toenails and it is caused mainly by dermatophytes. The aim of the study was to assess the frequency of onychomycoses in hemodialysis patients and to relate sex, age, duration of hemodialysis and causes of renal failure to the development of nail disorders. The study included 100 patients with chronic renal failure undergoing hemodialysis. The patients underwent detailed clinical examination of the toenails and those with any kind of clinical finding had nail scraping for mycological testing...
2013: Acta Dermatovenerologica Croatica: ADC
T Jones, A Tavakkol
The study objective was to evaluate the safety, tolerability, systemic exposure, and pharmacokinetics (PK) of 10% luliconazole solution (luliconazole) when topically applied once daily to all 10 toenails and periungual areas in patients with moderate to severe distal subungual onychomycosis. In this single-center, open-label study, 24 patients applied 20 mg/ml of luliconazole (twice the clinical dose) for 29 days with a 7-day follow-up. Complete PK profiles were determined on days 1, 8, 15, and 29. Safety/tolerability assessments included application site reactions, adverse events, vital signs, clinical laboratory findings, and electrocardiograms...
June 2013: Antimicrobial Agents and Chemotherapy
Ayako Yamada, Hiromitsu Noguchi, Hitoko Sakae, Takashi Sugita, Midori Hiruma, Masataro Hiruma
Onychomyosis caused by Aspergillus sydowii is rare and difficult to diagnose. We report a case in which this disease was diagnosed by molecular-biological methods. The patient was a 53-year-old woman without any notable past history. She visited our hospital complaining of itching around the right first toenail in June 2010, although she had noticed nail opacification for 4 years. Opaque thickening of the nail, covering 57.3% of the normal nail area, was observed. Direct microscopic examination revealed thick mycelia with septa and black spores...
2012: Medical Mycology Journal
Nardo Zaias, Gerbert Rebell, German Casal, Jason Appel
The aim of this investigation was to resolve a diagnostic problem and report toenail unit changes attributable to shoe friction that resemble onychomycosis, but that are fungus-negative, and identify common skeletal causes in patients with an asymmetric walking gait. X-ray and clinical feet inspections were performed to evaluate skeletal components that change normal foot biodynamics. Forty-nine patients, all dermatophyte-negative, were reviewed. All patients were those seen in our private practice who demonstrated skeletal and toenail unit abnormalities such as onycholysis, nail bed keratosis resembling distal subungual onychomycosis, nail plate surface abnormalities, distal toe skin keratosis, a diagnostic nail plate shape, as well as several skeletal abnormalities...
July 2012: Skinmed
(no author information available yet)
No abstract text is available yet for this article.
July 2012: Johns Hopkins Medical Letter Health After 50
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