keyword
https://read.qxmd.com/read/38217697/correction-chaotic-aging-intrinsically-disordered-proteins-in-aging-related-processes
#21
Vladimir D Manuylov, Nikolay S Ilyinsky, Semen V Nesterov, Baraa M G A Saqr, Guy W Dayhoff, Egor V Zinovev, Simon S Matrenok, Alexander V Fonin, Irina M Kuznetsova, Konstantin K Turoverov, Valentin Ivanovich, Vladimir N Uversky
No abstract text is available yet for this article.
January 13, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38176503/the-distal-proximal-relationships-among-the-human-moonlighting-proteins-evolutionary-hotspots-and-darwinian-checkpoints
#22
JOURNAL ARTICLE
Debaleena Nawn, Sk Sarif Hassan, Moumita Sil, Ankita Ghosh, Arunava Goswami, Pallab Basu, Guy W Dayhoff, Kenneth Lundstrom, Vladimir N Uversky
Moonlighting proteins, known for their ability to perform multiple, often unrelated functions within a single polypeptide chain, challenge the traditional "one gene, one protein, one function" paradigm. As organisms evolved, their genomes remained relatively stable in size, but the introduction of post-translational modifications and sub-strategies like protein promiscuity and intrinsic disorder enabled multifunctionality. Enzymes, in particular, exemplify this phenomenon, engaging in unrelated processes alongside their primary catalytic roles...
January 2, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38160960/autoimmune-response-after-sars-cov-2-infection-and-sars-cov-2-vaccines
#23
REVIEW
Altijana Hromić-Jahjefendić, Kenneth Lundstrom, Muhamed Adilović, Alaa A A Aljabali, Murtaza M Tambuwala, Ángel Serrano-Aroca, Vladimir N Uversky
The complicated relationships between autoimmunity, COVID-19, and COVID-19 vaccinations are described, giving insight into their intricacies. Antinuclear antibodies (ANA), anti-Ro/SSA, rheumatoid factor, lupus anticoagulant, and antibodies against interferon (IFN)-I have all been consistently found in COVID-19 patients, indicating a high prevalence of autoimmune reactions following viral exposure. Furthermore, the discovery of human proteins with structural similarities to SARS-CoV-2 peptides as possible autoantigens highlights the complex interplay between the virus and the immune system in initiating autoimmunity...
December 29, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/38158298/do-vaccines-increase-or-decrease-susceptibility-to-diseases-other-than-those-they-protect-against
#24
REVIEW
Alberto Rubio-Casillas, Cesar Manuel Rodriguez-Quintero, Elrashdy M Redwan, Munishwar Nath Gupta, Vladimir N Uversky, Mikolaj Raszek
Contrary to the long-held belief that the effects of vaccines are specific for the disease they were created; compelling evidence has demonstrated that vaccines can exert positive or deleterious non-specific effects (NSEs). In this review, we compiled research reports from the last 40 years, which were found based on the PubMed search for the epidemiological and immunological studies on the non-specific effects (NSEs) of the most common human vaccines. Analysis of information showed that live vaccines induce positive NSEs, whereas non-live vaccines induce several negative NSEs, including increased female mortality associated with enhanced susceptibility to other infectious diseases, especially in developing countries...
January 25, 2024: Vaccine
https://read.qxmd.com/read/38147698/stress-granules-p-bodies-and-cell-aging-a-bioinformatics-study
#25
JOURNAL ARTICLE
Yakov I Mokin, Nikolay S Ilyinsky, Semen V Nesterov, Eugene Y Smirnov, Olga S Sergeeva, Anna E Romanovich, Irina M Kuznetsova, Konstantin K Turoverov, Vladimir N Uversky, Alexander V Fonin
At the molecular level, aging is often accompanied by dysfunction of stress-induced membrane-less organelles (MLOs) and changes in their physical state (or material properties). In this work, we analyzed the proteins included in the proteome of stress granules (SGs) and P-bodies for their tendency to transform the physical state of these MLOs. Particular attention was paid to the proteins whose gene expression changes during replicative aging. It was shown that the proteome of the studied MLOs consists of intrinsically disordered proteins, 30-40% of which are potentially capable of liquid-liquid phase separation (LLPS)...
December 21, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38141525/small-angle-x-ray-scattering-structural-insights-into-alternative-pathway-of-actin-oligomerization-associated-with-inactivated-state
#26
JOURNAL ARTICLE
Yury L Ryzhykau, Olga I Povarova, Elizaveta A Dronova, Daria D Kuklina, Iuliia A Antifeeva, Nikolay S Ilyinsky, Ivan S Okhrimenko, Yury S Semenov, Alexander I Kuklin, Valentin Ivanovich, Alexander V Fonin, Vladimir N Uversky, Konstantin K Turoverov, Irina M Kuznetsova
In addition to the well-known monomeric globular (G-actin) and polymeric fibrillar (F-actin) forms, actin can exist in the so-called inactivated form (I-actin). Hsp70 chaperon, prefoldin, and CCT chaperonin are required to obtain native globular state. In contrast, I-actin is spontaneously formed in the absence of intracellular folding machinery. I-actin can be obtained from G-actin by elimination of divalent ion, incubation in presence of small concentrations of denaturants, and by heat exposure. Since G-actin is a quasi-stationary, thermodynamically unstable form, it can gradually transform into inactivated state in the absence of chelating/denaturating agents or heat exposure, but the transition is much slower...
November 29, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38136675/on-the-prevalence-and-roles-of-proteins-undergoing-liquid-liquid-phase-separation-in-the-biogenesis-of-pml-bodies
#27
JOURNAL ARTICLE
Sergey A Silonov, Yakov I Mokin, Eugene M Nedelyaev, Eugene Y Smirnov, Irina M Kuznetsova, Konstantin K Turoverov, Vladimir N Uversky, Alexander V Fonin
The formation and function of membrane-less organelles (MLOs) is one of the main driving forces in the molecular life of the cell. These processes are based on the separation of biopolymers into phases regulated by multiple specific and nonspecific inter- and intramolecular interactions. Among the realm of MLOs, a special place is taken by the promyelocytic leukemia nuclear bodies (PML-NBs or PML bodies), which are the intranuclear compartments involved in the regulation of cellular metabolism, transcription, the maintenance of genome stability, responses to viral infection, apoptosis, and tumor suppression...
December 18, 2023: Biomolecules
https://read.qxmd.com/read/38136611/protective-properties-of-s-layer-protein-2-from-lactobacillus-crispatus-2029-against-candida-albicans-infections
#28
JOURNAL ARTICLE
Vyacheslav M Abramov, Igor V Kosarev, Andrey V Machulin, Tatiana V Priputnevich, Evgenia I Deryusheva, Alexander N Panin, Irina O Chikileva, Tatiana N Abashina, Vyacheslav G Melnikov, Nataliya E Suzina, Ilia N Nikonov, Anna A Akhmetzyanova, Valentin S Khlebnikov, Vadim K Sakulin, Raisa N Vasilenko, Vladimir A Samoilenko, Alexey B Gordeev, Gennady T Sukhikh, Vladimir N Uversky, Andrey V Karlyshev
Previously, the protective role of the S-layer protein 2 (Slp2) of the vaginal Lactobacillus crispatus 2029 (LC2029) strain against foodborne pathogens Campylobacter jejuni , Salmonella enterica serovar Enteritidis, and Escherichia coli O157:H was demonstrated. We demonstrate the new roles of the Slp2-positive LC2029 strain and soluble Slp2 against C. albicans infections. We show that LC2029 bacteria can adhere to the surface of the cervical epithelial HeLa cells, prevent their contact with C. albicans , and block yeast transition to a pathogenic hyphal form...
December 4, 2023: Biomolecules
https://read.qxmd.com/read/38113978/the-role-of-the-gut-microbiome-in-gastrointestinal-cancers
#29
REVIEW
Yachana Mishra, Abhigyan Ranjan, Vijay Mishra, Aditi Chattaraj, Alaa A A Aljabali, Mohamed El-Tanani, Altijana Hromić-Jahjefendić, Vladimir N Uversky, Murtaza M Tambuwala
The gut microbiota present in the human digestive system is incredibly varied and is home to trillions of microorganisms. The gut microbiome is shaped at birth, while numerous genetic, dietary, and environmental variables primarily influence the microbiome composition. The importance of gut microbiota on host health is becoming more widely acknowledged. Digestion, intestinal permeability, and immunological and metabolism responses can all be affected by changes in the composition and function of the gut microbiota...
December 17, 2023: Cellular Signalling
https://read.qxmd.com/read/38098317/intrinsic-factors-behind-long-covid-iii-persistence-of-sars-cov-2-and-its-components
#30
REVIEW
Nawal Abd El-Baky, Amro A Amara, Vladimir N Uversky, Elrashdy M Redwan
Considerable research has been done in investigating SARS-CoV-2 infection, its characteristics, and host immune response. However, debate is still ongoing over the emergence of post-acute sequelae of SARS-CoV-2 infection (PASC). A multitude of long-lasting symptoms have been reported several weeks after the primary acute SARS-CoV-2 infection that resemble several other viral infections. Thousands of research articles have described various post-COVID-19 conditions. Yet, the evidence around these ongoing health problems, the reasons behind them, and their molecular underpinnings are scarce...
December 14, 2023: Journal of Cellular Biochemistry
https://read.qxmd.com/read/38061507/biological-importance-of-arginine-a-comprehensive-review-of-the-roles-in-structure-disorder-and-functionality-of-peptides-and-proteins
#31
REVIEW
Munishwar Nath Gupta, Vladimir N Uversky
Arginine shows Jekyll and Hyde behavior in several respects. It participates in protein folding via ionic and H-bonds and cation-pi interactions; the charge and hydrophobicity of its side chain makes it a disorder-promoting amino acid. Its methylation in histones; RNA binding proteins; chaperones regulates several cellular processes. The arginine-centric modifications are important in oncogenesis and as biomarkers in several cardiovascular diseases. The cross-links involving arginine in collagen and cornea are involved in pathogenesis of tissues but have also been useful in tissue engineering and wound-dressing materials...
December 5, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38035951/investigating-the-effect-of-ph-on-the-interaction-of-cypermethrin-with-human-serum-albumin-insights-from-spectroscopic-and-molecular-dynamics-simulation-studies
#32
JOURNAL ARTICLE
Mohammad Ali Mohammadi, Behzad Shareghi, Sadegh Farhadian, Vladimir N Uversky
To efficiently combat the negative consequences of the utilization of pesticides and hazardous substances with biomolecules, it is crucial to comprehend the features of the corresponding compounds. In this study, interactions between cypermethrin (CYP) and HSA at neutral and acidic pH were investigated using a set of spectroscopic and computational tools, such as UV/VIS's absorption spectroscopy, fluorescence, Fourier-transform infrared (FTIR) spectroscopy, molecular docking, and molecular dynamics. Furthermore, the effect of CYP on the HSA thermal stability was investigated...
November 28, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37992221/intrinsically-disordered-proteins-and-liquid-liquid-phase-separation-in-sars-cov-2-interactomes
#33
JOURNAL ARTICLE
Lazar M Vasović, Gordana M Pavlović-Lažetić, Jovana J Kovačević, Miloš V Beljanski, Vladimir N Uversky
This paper discusses the properties of proteins and their relations in the interactomes of the selected subsets of SARS-CoV-2 proteome-the membrane protein, nonstructural proteins, and, finally, full proteome. Protein disorder according to several measures, liquid-liquid phase separation probabilities, and protein node degrees in the interaction networks were singled out as the features of interest. Additionally, viral interactomes were combined with the interactome of human lung tissue so as to examine if the new connections in the resulting viral-host interactome are linked to protein disorder...
November 22, 2023: Journal of Cellular Biochemistry
https://read.qxmd.com/read/37987564/a-conserved-ribosomal-protein-has-entirely-dissimilar-structures-in-different-organisms
#34
JOURNAL ARTICLE
Léon Schierholz, Charlotte R Brown, Karla Helena-Bueno, Vladimir N Uversky, Robert P Hirt, Jonas Barandun, Sergey V Melnikov
Ribosomes from different species can markedly differ in their composition by including dozens of ribosomal proteins that are unique to specific lineages but absent in others. However, it remains unknown how ribosomes acquire new proteins throughout evolution. Here, to help answer this question, we describe the evolution of the ribosomal protein msL1/msL2 that was recently found in ribosomes from the parasitic microorganism clade, microsporidia. We show that this protein has a conserved location in the ribosome but entirely dissimilar structures in different organisms: in each of the analyzed species, msL1/msL2 exhibits an altered secondary structure, an inverted orientation of the N- and C-termini on the ribosomal binding surface, and a completely transformed three-dimensional fold...
November 21, 2023: Molecular Biology and Evolution
https://read.qxmd.com/read/37890707/microproteins-transitioning-into-a-new-phase-defining-the-undefined
#35
JOURNAL ARTICLE
Aayushi Sahgal, Vladimir Uversky, Vrushank Davé
Recent advancements in omics technologies have unveiled a hitherto unknown group of short polypeptides called microproteins (miPs). Despite their size, accumulating evidence has demonstrated that miPs exert varied and potent biological functions. They act in paracrine, juxtracrine, and endocrine fashion, maintaining cellular physiology and driving diseases. The present study focuses on biochemical and biophysical analysis and characterization of twenty-four human miPs using distinct computational methods, including RIDAO, AlphaFold2, D2 P2 , FuzDrop, STRING, and Emboss Pep wheel...
October 25, 2023: Methods: a Companion to Methods in Enzymology
https://read.qxmd.com/read/37887236/-ligilactobacillus-salivarius-7247-strain-probiotic-properties-and-anti-salmonella-effect-with-prebiotics
#36
JOURNAL ARTICLE
Vyacheslav M Abramov, Igor V Kosarev, Andrey V Machulin, Evgenia I Deryusheva, Tatiana V Priputnevich, Alexander N Panin, Irina O Chikileva, Tatiana N Abashina, Ashot M Manoyan, Anna A Ahmetzyanova, Olga E Ivanova, Tigran T Papazyan, Ilia N Nikonov, Nataliya E Suzina, Vyacheslav G Melnikov, Valentin S Khlebnikov, Vadim K Sakulin, Vladimir A Samoilenko, Alexey B Gordeev, Gennady T Sukhikh, Vladimir N Uversky
The Ligilactobacillus salivarius 7247 (LS7247) strain, originally isolated from a healthy woman's intestines and reproductive system, has been studied for its probiotic potential, particularly against Salmonella Enteritidis (SE) and Salmonella Typhimurium (ST) as well as its potential use in synbiotics. LS7247 showed high tolerance to gastric and intestinal stress and effectively adhered to human and animal enterocyte monolayers, essential for realizing its probiotic properties. LS7247 showed high anti- Salmonella activity...
October 12, 2023: Antibiotics
https://read.qxmd.com/read/37845006/a-cell-penetrant-peptide-disrupting-the-transcription-factor-cp2c-complexes-induces-cancer-specific-synthetic-lethality
#37
JOURNAL ARTICLE
Seung Han Son, Min Young Kim, Sungwoo Choi, Ji Sook Kim, Yong Sang Lee, Sangwon Lee, Yeon Ju Lee, Jin Youn Lee, Seol Eui Lee, Young Su Lim, Dae Hyun Ha, Eonju Oh, Young-Bin Won, Chang-Jun Ji, Mi Ae Park, Boram Kim, Kyu Tae Byun, Min Sung Chung, Jaemin Jeong, Dongho Choi, Eun Jung Baek, Eung-Ho Cho, Sang-Bum Kim, A Reum Je, Hee-Seok Kweon, Hyun Sook Park, Dongsun Park, June Sung Bae, Se Jin Jang, Chae-Ok Yun, Ji Hyung Chae, Jin-Won Lee, Su-Jae Lee, Chan Gil Kim, Ho Chul Kang, Vladimir N Uversky, Chul Geun Kim
Despite advances in precision oncology, cancer remains a global public health issue. In this report, proof-of-principle evidence is presented that a cell-penetrable peptide (ACP52C) dissociates transcription factor CP2c complexes and induces apoptosis in most CP2c oncogene-addicted cancer cells through transcription activity-independent mechanisms. CP2cs dissociated from complexes directly interact with and degrade YY1, leading to apoptosis via the MDM2-p53 pathway. The liberated CP2cs also inhibit TDP2, causing intrinsic genome-wide DNA strand breaks and subsequent catastrophic DNA damage responses...
October 16, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/37828519/correction-intrinsic-disorder-in-prame-and-its-role-in-uveal-melanoma
#38
Michael Antonietti, David J Taylor Gonzalez, Mak Djulbegovic, Guy W Dayhoff, Vladimir N Uversky, Carol L Shields, Carol L Karp
No abstract text is available yet for this article.
October 12, 2023: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/37812573/implications-of-intrinsic-disorder-and-functional-proteomics-in-the-merkel-cell-polyomavirus-life-cycle
#39
JOURNAL ARTICLE
Nathan Lanclos, Peter Radulovic, Jackson Bland, Valentin Oganisyan, Kelton Radefeld, Vladimir N Uversky
Infection with merkel cell polyomavirus (MCPyV) is implicated in the development of merkel cell carcinoma (MCC), a rare but aggressive skin cancer. MCC has a mortality rate near 50%, and incidence has been rapidly increasing in recent decades, making development of improved treatment strategies critical to addressing its growing social burden. The parallel increasing necessity for novel research to better understand MCPyV pathogenesis has prompted numerous studies in recent years, yet the role of intrinsic disorder in MCPyV proteins remains unexplored...
October 9, 2023: Journal of Cellular Biochemistry
https://read.qxmd.com/read/37801299/intrinsic-factors-behind-long-covid-ii-sars-cov-2-extracellular-vesicles-and-neurological-disorders
#40
REVIEW
Yousra A El-Maradny, Alberto Rubio-Casillas, Kareem I Mohamed, Vladimir N Uversky, Elrashdy M Redwan
With the decline in the number of new Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections, the World Health Organization announced the end of the SARS-CoV-2 pandemic. However, the repercussions of this viral pandemic may remain with us for a longer period of time, as it has remodeled the lives of humankind in many ways, including social and economic. Of course, its most important repercussions remain on the human health level. Long-coronavirus disease (COVID) or post-COVID is a state for which we do not have a concrete definition, a specific international classification of diseases Code, clear diagnostic tools, or well-known effective cures as of yet...
October 6, 2023: Journal of Cellular Biochemistry
keyword
keyword
76386
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.