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https://www.readbyqxmd.com/read/28226737/4d-lung-tumor-segmentation-via-shape-prior-and-motion-cues
#1
Jung Won Cha, Mohammad M Farhangi, Neal Dunlap, Amir Amini, Jung Won Cha, Mohammad M Farhangi, Neal Dunlap, Amir Amini, Jung Won Cha, Amir Amini, Neal Dunlap, Mohammad M Farhangi
Lung tumor segmentation is important for therapy in the radiation treatment of patients with thoracic malignancies. In this paper, we describe a 4D image segmentation method based on graph-cuts optimization, shape prior and optical flow. Due to small size, the location, and low contrast between the tumor and the surrounding tissue, tumor segmentation in 3D+t is challenging. We performed 4D lung tumor segmentation in 5 patients, and in each case compared the results with the expert-delineated lung nodules. In each case, 4D image segmentation took approximately ten minutes on a PC with AMD Phenom II and 32GB of memory for segmenting tumor in five phases of lung CT data...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223153/evaluations-of-implementation-at-early-adopting-lung-cancer-screening-programs-lessons-learned
#2
Yaron B Gesthalter, Elisa Koppelman, Rendelle Bolton, Christopher G Slatore, Sue H Yoon, Hilary C Cain, Nichole T Tanner, David H Au, Jack A Clark, Renda Soylemez Wiener
BACKGROUND: Guidelines recommend lung cancer screening and it is currently being adopted nationwide. The American College of Chest Physicians advises inclusion of specific programmatic components to ensure high-quality screening. However, little is known about how lung cancer screening has been implemented in practice. We sought to evaluate the experience of early-adopting programs, characterize barriers faced, and identify strategies to achieve successful implementation. METHODS: We performed qualitative evaluations of lung cancer screening implementation at three Veterans Health Administration facilities, conducting semi-structured interviews with key staff (n=29)...
February 18, 2017: Chest
https://www.readbyqxmd.com/read/28222740/dibutyryl-camp-attenuates-pulmonary-fibrosis-by-blocking-myofibroblast-differentiation-via-pka-creb-cbp-signaling-in-rats-with-silicosis
#3
Yan Liu, Hong Xu, Yucong Geng, Dingjie Xu, Lijuan Zhang, Yi Yang, Zhongqiu Wei, Bonan Zhang, Shifeng Li, Xuemin Gao, Ruimin Wang, Xianghong Zhang, Darrell Brann, Fang Yang
BACKGROUND: Myofibroblasts play a major role in the synthesis of extracellular matrix (ECM) and the stimulation of these cells is thought to play an important role in the development of silicosis. The present study was undertaken to investigate the anti-fibrotic effects of dibutyryl-cAMP (db-cAMP) on rats induced by silica. METHODS: A HOPE MED 8050 exposure control apparatus was used to create the silicosis model. Rats were randomly divided into 4 groups: 1)controls for 16 w; 2)silicosis for 16 w; 3)db-cAMP pre-treatment; 4) db-cAMP post-treatment...
February 21, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28222720/birt-hogg-dub%C3%A3-syndrome-a-literature-review-and-case-study-of-a-chinese-woman-presenting-a-novel-flcn-mutation
#4
Shengyu Hao, Fei Long, Fenglan Sun, Teng Liu, Daowei Li, Shujuan Jiang
BACKGROUND: The Birt-Hogg-Dubé (BHD) syndrome is a very rare autosomal dominant form of genodermatosis caused by germline mutations in the folliculin (FLCN) gene, which is mapped to the p11.2 region in chromosome 17. BHD commonly presents cutaneous fibrofolliculomas, pulmonary cysts, renal cell carcinoma, and recurrent pneumothoraxes. The disease is easily ignored or misdiagnosed as pneumothorax, pulmonary lymphangiomyomatosis (LAM), or emphysema. Follow-up and guidelines for managing recurrent pneumothoraxes in these patients are lacking...
February 21, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28219077/radiopathological-features-and-identification-of-mycobacterial-infections-in-granulomatous-nodules-resected-from-the-lung
#5
Yumi Sakakibara, Yoshimi Suzuki, Toshihide Fujie, Takumi Akashi, Tadatsune Iida, Yasunari Miyazaki, Yoshinobu Eishi, Naohiko Inase
BACKGROUND: Pulmonary granulomas are sometimes resected because they resemble lung cancer and false-positive findings come through from positron emission tomography (PET) using 18fluorine-fluorodeoxyglucose (18F-FDG). Mycobacterial infection is a common cause of granulomas. OBJECTIVE: The purpose of this study was to evaluate the radiopathological features and the methods for identifying mycobacterial infections in granulomatous nodules resected from the lung. METHODS: Thirty-five solitary lesions resected because of suspected lung cancer were enrolled, including 22 nonfungal granulomatous lesions and 13 benign lesions as controls...
February 21, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28217605/a-rare-cause-of-misdiagnosis-in-chest-x-ray
#6
Carlos Manuel Ortiz-Mendoza
Chest X-ray is a usual tool for family physicians; however, unexpected findings in chest X-ray are a frequent challenge. We present a rare case of pulmonary hilar nodule misdiagnosis in a chest X-ray. An 84-year-old woman was sent with a diagnosis of a right pulmonary hilum nodule. She had a history of chronic obstructive pulmonary disease; so in a chest X-ray, her family physician discovered a "nodule" in her right lung hilum. Her physical exam was not relevant. In our hospital, a thoracic computed tomography (CT) scan verified the mass in the right pulmonary hilum; nevertheless, in a coronal CT scan, the "hilum lump" was the tortuous descending aorta that created an angle...
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28216872/thyroid-mass-metastasis-from-nasopharyngeal-cancer-an-unusual-presentation
#7
Shirley C Lewis, Anil K D'cruz, Amit Joshi, Rajiv Kumar, Shubhada V Kane, Sarbani Ghosh Laskar
Thyroid gland is an uncommon site of metastasis, and metastasis to the gland secondary to nasopharyngeal carcinoma is seldom seen. We were only able to identify eight reported cases in the literature. A 61-year-old man, diagnosed case of nasopharyngeal cancer-second primary ( first primary-oropharynx), was found to have a thyroid nodule on routine follow-up positron emission tomography-computed tomography (PET-CT) scan. There was no evidence of metastases at any other sites. The thyroid nodule was confirmed as metastatic carcinoma by fine needle aspiration cytology...
January 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/28216527/usefulness-of-intraoperative-cone-beam-ct-images-on-video-assisted-thoracic-surgery
#8
Harutaka Hisano, Tohru Sakuragi, Yoshinobu Kakiuchi, Satoshi Takita, Yuuji Takeda, Shigeki Morita, Hiroyuki Irie
For the resection of pulmonary ground glass opacity (GGO) or non-palpable nodule on video-assisted thoracic surgery (VATS), preoperative computed tomography (CT)-guided VATS marker pricking is usually performed. Recently, air embolisms after VATS marker pricking have been reported to be serious problems. The purpose of this study was to evaluate the usefulness of intraoperative cone beam CT images on VATS to avoid preoperative VATS marker pricking. The CT number of the both GGO and nodule indicate the range from -200 to -800 HU in general...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/28214126/pulmonary-nodules-in-african-migrants-caused-by-chronic-schistosomiasis
#9
REVIEW
Federico Gobbi, Dora Buonfrate, Andrea Angheben, Anna Beltrame, Matteo Bassetti, Luca Bertolaccini, Giuseppe Bogina, Simone Caia, Silvia Duranti, Maria Gobbo, Valentina Marchese, Stefania Marocco, Maria Merelli, Geraldo Monteiro, Alberto Terzi, Zeno Bisoffi
Schistosomiasis is a neglected tropical disease that can cause mainly hepatic and genitourinary damage, depending on the species. Involvement of the lungs has been commonly described in acute infection (Katayama syndrome) and chronic infection (pulmonary hypertension). Although rarely reported in the scientific literature, cases of lung nodules due to chronic schistosome infection are also possible and are probably more frequent than commonly thought. Here we report seven cases of African migrants who were diagnosed with chronic schistosomiasis and pulmonary nodules due to deposition of schistosome eggs, and we compare our findings to the case reports found in the scientific literature...
February 14, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28212561/the-tlr7-agonist-imiquimod-induces-anti-cancer-effects-via-autophagic-cell-death-and-enhances-anti-tumoral-and-systemic-immunity-during-radiotherapy-for-melanoma
#10
Jeong Hyun Cho, Hyo-Ji Lee, Hyun-Jeong Ko, Byung-Il Yoon, Jongseon Choe, Keun-Cheol Kim, Tae-Wook Hahn, Jeong A Han, Sun Shim Choi, Young Mee Jung, Kee-Ho Lee, Yun-Sil Lee, Yu-Jin Jung
Toll-like receptor (TLR) ligands are strongly considered immune-adjuvants for cancer immunotherapy and have been shown to exert direct anti-cancer effects. This study was performed to evaluate the synergistic anti-cancer and anti-metastatic effects of the TLR7 agonist imiquimod (IMQ) during radiotherapy for melanoma. The pretreatment of B16F10 or B16F1 cells with IMQ combined with γ-ionizing radiation (IR) led to enhanced cell death via autophagy, as demonstrated by increased expression levels of autophagy-related genes, and an increased number of autophagosomes in both cell lines...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28203428/multiple-cavitating-pulmonary-nodules-rare-manifestation-of-benign-metastatic-leiomyoma
#11
Sa Ra Lee, Youn-I Choi, Seok Jeong Lee, Sung Shine Shim, Jin Hwa Lee, Yoo Kyung Kim, Soon Hee Sung
Benign metastasizing leiomyoma (BML) is a rare disease of pathologically benign, but the tumor metastasizes to other organs. The most common organ involved in BML is lung. Pulmonary involvement usually manifested as multiple nodules on chest X-ray, however we experienced an interesting case of a 52-year-old premenopausal woman who presented with multiple bilateral lung cavitations and nodules on a chest X-ray without any respiratory symptoms. Chest computed-tomography identified multiple cavitary lesions of 5-12 mm in diameter and well-defined nodules of 5-10 mm in diameter in both lung fields...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28202941/risk-of-pleural-recurrence-in-early-stage-lung-cancer-patients-after-percutaneous-transthoracic-needle-biopsy-a-meta-analysis
#12
Ting Wang, Lili Luo, Qinghua Zhou
Percutaneous transthoracic needle biopsies (PTNB) are widely used for the diagnosis of a peripheral pulmonary nodules, but the risk of pleural recurrence in lung cancer patients remains undetermined. Our meta-analysis aims to answer the question whether PTNB strategy increases the risk of recurrence. PubMed, EMBASE, The Cochrane Library, and China National Knowledge Infrastructure (CNKI) were searched from inception to January 9, 2016. A total of 1242 patients from 5 studies were included. The results showed that PTNB does not increase risk of total recurrence (Odds Ratio,0...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28197820/lung-cancer-screening-with-ultra-low-dose-ct-using-full-iterative-reconstruction
#13
Masayo Fujita, Toru Higaki, Yoshikazu Awaya, Toshio Nakanishi, Yuko Nakamura, Fuminari Tatsugami, Yasutaka Baba, Makoto Iida, Kazuo Awai
PURPOSE: To investigate the diagnostic capability of ultra-low-dose CT (ULDCT) with full iterative reconstruction (f-IR) for lung cancer screening. MATERIALS AND METHODS: All underwent ULDCT and/or low-dose CT (LD-CT) on a 320-detector scanner. ULDCT images were reconstructed with f-IR. We qualitatively and quantitatively studied 95 nodules in 69 subjects. Two radiologists classified the nodules on ULDCT images as solid-, part-solid-, and pure ground-glass (PGG) and recorded their mean size...
February 14, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28195907/solitary-psma-positive-pulmonary-metastasis-in-biochemical-relapse-of-prostate-cancer
#14
Nils Groe Hokamp, Carsten Kobe, Eric Linzenich, David Maintz, Alexander Drzezga
A 63-year-old man with a history of prostate cancer, treated with resection, radiation, and androgen-depriving therapy over 4 years, was referred to our department with suspicion of recurrence based on increased blood PSA levels (1.60 ng/mL). Ga PSMA PET/CT identified a solitary, PSMA-positive pulmonary nodule in the right lung. After resection, histologic analysis confirmed prostatic origin, and the blood PSA level decreased to 0.13 ng/mL. Solitary pulmonary metastasis from prostate cancer is rare. The benefits of local treatment of a single metastasis even in advanced disease are disputed among oncologists...
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28194229/circulating-and-tissue-biomarkers-in-early-stage-non-small-cell-lung-cancer
#15
Caterina Fumagalli, Fabrizio Bianchi, Paola Rafaniello Raviele, Davide Vacirca, Giovanni Bertalot, Cristiano Rampinelli, Matteo Lazzeroni, Bernardo Bonanni, Giulia Veronesi, Nicola Fusco, Massimo Barberis, Elena Guerini-Rocco
OBJECTIVE: We sought to characterise circulating and tissue tumour biomarkers of patients who developed early-stage non-small cell lung cancer (NSCLC) during long-term follow-up of a chemoprevention trial (NCT00321893). MATERIALS AND METHODS: Blood and sputum samples were collected from 202 high-risk asymptomatic individuals with CT-detected stable lung nodules. Real-time PCR was performed on plasma to quantify free circulating DNA. Baseline serum was investigated with a previously validated test based on 13 circulating miRNAs (miR-Test)...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28194087/occupational-bronchiolitis-induced-by-cotton-dust-exposure-in-a-nonsmoker
#16
Richa Mittal, Pawan Gupta, Sunil K Chhabra
The most well-known disease caused by cotton dust is byssinosis though it is also associated with chronic obstructive airways disease, and very rarely, interstitial lung disease. Obliterative bronchiolitis has never been reported in this setting. We report a 63-year-old, nonsmoker male, who presented with complaints of cough and exertional dyspnoea for 10 years. He had worked in textile industry for 35 years and symptoms had persisted even after quitting. Examination revealed prolonged expiration with expiratory wheeze, and pulmonary function tests revealed severe airflow limitation with air trapping and impaired diffusion capacity...
May 2016: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28192888/computed-tomography-morphologic-features-of-pulmonary-adenocarcinoma-with-brain-bone-metastasis
#17
Ki-Eun Hwang, Su-Jin Oh, Chul Park, Se-Jeong Jeon, Jeong-Mi Lee, Byong-Ki Cha, Kwon-Ha Yoon, Eun-Taik Jeong, Hak-Ryul Kim
Background/Aims: Brain and bone metastases are common in patients with lung cancer. The development of metastasis is associated with poor survival in lung cancer patients. Although tumor morphologic features on radiographs are routinely assessed for differentiation between benign and malignant lung nodules, they are not used to predict metastasis. We assessed morphologic features of pulmonary adenocarcinomas with brain/bone metastasis on computed tomography (CT) to identify related factors for metastasis...
February 15, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28191607/retrospective-study-of-the-clinical-characteristics-and-risk-factors-of-rheumatoid-arthritis-associated-interstitial-lung-disease
#18
Yongfeng Zhang, Hongbin Li, Nawei Wu, Xin Dong, Yi Zheng
This study aims to explore the clinical characteristics and risk factors of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD). This is a retrospective study of 550 patients with RA. All patients underwent chest high-resolution computed tomography (HRCT) scanning. (1) Two hundred thirty-seven out of five hundred fifty (43.1%) patients with RA were diagnose with ILD. 13.5% ILD occurred before RA onset, 69.6% ILD occurred within 10 years of RA onset, and 16.9% ILD occurred more than 10 years after RA onset...
February 12, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28188426/non-specific-benign-pathological-results-on-transthoracic-core-needle-biopsy-how-to-differentiate-false-negatives
#19
Jung Im Kim, Chang Min Park, Hyungjin Kim, Jong Hyuk Lee, Jin Mo Goo
OBJECTIVES: To determine the negative predictive value (NPV) of non-specific benign results from cone-beam CT (CBCT)-guided transthoracic core-needle biopsy (TTNB) and identify predicting factors for false-negative for malignancies. METHODS: From January 2009-December 2011, 1,108 consecutive patients with 1,116 lung lesions underwent CBCT-guided TTNB using an 18-gauge coaxial cutting needle. Among them, 226 patients with 226 TTNBs, initially diagnosed as non-specific benign, were included in this study...
February 10, 2017: European Radiology
https://www.readbyqxmd.com/read/28187776/mycobacterium-bovis-in-a-european-bison-bison-bonasus-raises-concerns-about-tuberculosis-in-brazilian-captive-wildlife-populations-a-case-report
#20
Cristina Kraemer Zimpel, Juliana Sperotto Brum, Antônio Francisco de Souza Filho, Alexander Welker Biondo, João Henrique Perotta, Cristina Corsi Dib, Marcelo Bonat, José Soares Ferreira Neto, Paulo Eduardo Brandão, Marcos Bryan Heinemann, Ana Marcia Sa Guimaraes
BACKGROUND: Tuberculosis caused by Mycobacterium bovis is an important worldwide zoonosis and has been reported to cause clinical disease in several animal species, including captive wildlife. This report describes a case of M. bovis infection in a European bison from a Brazilian zoo and compiles a number of literature reports that raise concern regarding tuberculosis among captive wildlife in Brazil. CASE PRESENTATION: A 13 year-old captive-born male bison (Bison bonasus) from a Brazilian zoo began presenting weight loss, diarrhea and respiratory symptoms, which inevitably led to his death...
February 10, 2017: BMC Research Notes
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