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https://www.readbyqxmd.com/read/29471517/the-role-of-the-ground-glass-opacity-ratio-in-resected-lung-adenocarcinoma
#1
Tsai-Wang Huang, Kuan-Hsun Lin, Hsu-Kai Huang, Yi-I Chen, Kai-Hsiung Ko, Cheng-Kuang Chang, Hsian-He Hsu, Hung Chang, Shih-Chun Lee
OBJECTIVES: The goal of this study was to investigate the role of the ground-glass opacity (GGO) ratio in lung adenocarcinoma in predicting surgical outcomes. METHODS: Patients who underwent surgical resection for pulmonary adenocarcinoma between January 2004 and December 2013 were reviewed. The clinical data, imaging characteristics of nodules, surgical approaches and outcomes were analysed with a mean follow-up of 87 months. RESULTS: Of 789 enrolled patients, 267 cases were categorized as having a GGO ratio ≥0...
February 19, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29465823/differential-expression-of-various-clones-of-estrogen-receptor-in-cell-block-preparation-of-lung-adenocarcinoma
#2
Laleh Hakima, Kathie Schlesinger, Jaya Sunkara, Rouzan G Karabakhtsian
BACKGROUND: Women treated for breast cancer are at increased risk of developing pulmonary nodules which could represent new primary lung carcinomas or metastatic breast carcinoma. The FNA biopsy is frequently the first diagnostic choice in determining the primary site of the tumor. Estrogen receptor (ER) positivity in diagnostic tissue is generally used to favor breast over lung primary. However, the recent studies have shown a wide range of ER antibody cross reactivity with lung adenocarcinoma...
February 21, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29464077/complement-c4d-specific-antibodies-for-the-diagnosis-of-lung-cancer
#3
Daniel Ajona, Marcin Okrój, María J Pajares, Jackeline Agorreta, María D Lozano, Javier J Zulueta, Carla Verri, Luca Roz, Gabriella Sozzi, Ugo Pastorino, Pierre P Massion, Luis M Montuenga, Anna M Blom, Ruben Pio
Development of molecular markers that help to identify high-risk individuals or diagnose indeterminate pulmonary nodules could have a major impact on lung cancer clinical management. In this study, we evaluated the diagnostic potential of a newly-developed ELISA that specifically detects complement C4d. We measured this marker in five independent cohorts of plasma and bronchoalveolar lavage samples from lung cancer patients and controls. In case-control studies, the area under the ROC curve for the diagnosis of lung cancer was 0...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29463557/the-airway-transcriptome-as-a-biomarker-for-early-lung-cancer-detection
#4
Ehab Billatos, Jessica L Vick, Marc E Lenburg, Avrum E Spira
Lung cancer remains the leading cause of cancer-related death due to its advanced stage at diagnosis. Early detection of lung cancer can be improved by better defining who should be screened radiographically, and determining which imaging-detected pulmonary nodules are malignant. Gene expression biomarkers measured in normal-appearing airway epithelium provide an opportunity to use lung cancer associated molecular changes in this tissue for early detection of lung cancer. Molecular changes in the airway may result from an etiologic field of injury and/or field cancerization...
February 20, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29463465/secondary-pulmonary-syphilis-case-report-and-review-of-literature
#5
H Kassem Youssef, A Blind, F Chouta Ngaha, B Drenou, H Nojavan, C Michel
INTRODUCTION: Syphilis is a sexually transmitted disease that can affect numerous organs in its secondary or tertiary stages. We describe a case of secondary syphilis with pulmonary involvement and we present a literature review. PATIENTS AND METHODS: A 69-year-old male patient was admitted to hospital for dyspnoea and extended papular exanthema with palmoplantar involvement. The serological test for syphilis was positive. Ocular examination showed bilateral papillitis and retinal haemorrhage...
February 17, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29461911/small-cell-lung-cancer-transformation-from-egfr-mutated-lung-adenocarcinoma-a-case-report-and-literatures-review
#6
Yangyang Liu
Epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have markedly improved the response of non-small cell lung cancer (NSCLC) with EGFR-mutant patients. However, these patients inevitably come cross acquired resistance to EGFR-TKIs. The transformation of lung adenocarcinoma to small cell lung cancer (SCLC) following treatment with EGFR-TKIs is rare, which leads to resistance to EGFR-TKIs. The present case concerns a case of a 38-year-old man presenting with cough and dyspnea. Radical resection was performed and confirmed an EGFR exon 21 L858R lung adenocarcinoma...
February 20, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29457229/radiomics-analysis-of-pulmonary-nodules-in-low-dose-ct-for-early-detection-of-lung-cancer
#7
Wookjin Choi, Jung Hun Oh, Sadegh Riyahi, Chia-Ju Liu, Feng Jiang, Wengen Chen, Charles White, Andreas Rimner, James G Mechalakos, Joseph O Deasy, Wei Lu
PURPOSE: To develop a radiomics prediction model to improve pulmonary nodule (PN) classification in low-dose CT. To compare the model with the American College of Radiology (ACR) Lung CT Screening Reporting and Data System (Lung-RADS) for early detection of lung cancer. METHODS: We examined a set of 72 PNs (31 benign and 41 malignant) from the Lung Image Database Consortium image collection (LIDC-IDRI). 103 CT radiomic features were extracted from each PN. Before the model building process, distinctive features were identified using a hierarchical clustering method...
February 19, 2018: Medical Physics
https://www.readbyqxmd.com/read/29455962/needle-localization-of-small-pulmonary-nodules-lessons-learned
#8
Patricia A Thistlethwaite, Jonathan R Gower, Moises Hernandez, Yu Zhang, Andrew C Picel, Anne C Roberts
BACKGROUND: Lung nodules that are small and deep within lung parenchyma, and have semisolid characteristics are often challenging to localize with video-assisted thoracoscopic surgery (VATS). We describe our cumulative experience using needle localization of small nodules before surgical resection. We report procedural tips, operative results, and lessons learned over time. METHODS: A retrospective review of all needle localization cases between July 1, 2006, and December 30, 2016, at a single institution was performed...
January 17, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29455176/late-diagnosis-a-case-of-rapidly-progressive-extranodal-nk-t-cell-lymphoma-nasal-type
#9
Hiroyuki Mori, Kei Ebisawa, Mitsushige Nishimura, Kenji Kanazawa
Extranodal natural killer (NK)/T cell lymphoma, nasal type is a condition that has poor prognosis. Accurate diagnosis of lymphoma is made by pathological findings. We report a case of extranodal NK/T cell lymphoma, nasal type affecting the lung and liver and which was difficult to diagnose because of negative biopsy results from multiple sites. A 39-year-old man who had dry cough and fever for 1 month was referred to our hospital. He had pancytopenia and elevated serum levels of lactate dehydrogenase and soluble interleukin-2 receptor...
February 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29454587/comparison-of-ct-radiogenomic-and-clinical-characteristics-between-egfr-and-kras-mutations-in-lung-adenocarcinomas
#10
J Lv, H Zhang, J Ma, Y Ma, G Gao, Z Song, Y Yang
AIM: To compare computed tomography (CT) radiogenomic and clinical characteristics between patients with epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) mutations in lung adenocarcinomas. MATERIALS AND METHODS: This study was a retrospective analysis of patients with histopathologically confirmed lung adenocarcinoma, who had complete clinical and imaging data, and were tested for EGFR and KRAS mutations. Of the 313 included patients, 116 had effective EGFR mutations (EGFR group), 31 had KRAS mutations (KRAS group), and 166 had no EGFR or KRAS mutations (control group)...
February 14, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29451344/a-case-of-microscopic-multiple-sclerosing-pneumocytoma
#11
Hitomi Kawai, Norio Takayashiki, Haruo Otani, Shingo Sakashita, Masayuki Noguchi
Sclerosing pneumocytoma is a rare tumor of the lung, commonly affecting middle-aged women, and is mostly isolated. Although this tumor is thought to be derived from primitive respiratory epithelial cells, the characteristics of the precursor cells are still unknown. A 19-year-old woman presented with multiple nodules in the right lung. Partial resection of the right middle lobe was performed, and seven sclerosing pneumocytomas, including four that were microscopic, were detected. The latter showed a simple papillary pattern, and three of them consisted of only round cell-like cells (single population)...
February 16, 2018: Pathology International
https://www.readbyqxmd.com/read/29450699/consolidation-tumor-ratio-on-chest-computed-tomography-as-predictor-of-postoperative-nodal-upstaging-in-clinical-t1n0-lung-cancer
#12
Youngkyu Moon, Jae Kil Park, Kyo Young Lee, Min Namkoong, Seha Ahn
BACKGROUND: In clinical T1N0 peripheral lung cancers, lymph node upstaging is occasionally encountered postoperatively. However, nodal upstaging is rare in lung cancers presenting as ground-glass opacities. The aim of this study was to determine if lymph node upstaging could be reliably extrapolated from parameters such the consolidation/tumor ratio of chest computed tomography. METHODS: We conducted a retrospective study of 486 patients treated for peripheral clinical T1N0 non-small cell lung cancer, each undergoing lobectomy with mediastinal lymph node dissection...
February 15, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29446832/an-assessment-of-18-f-fdg-pet-ct-for-thoracic-screening-and-risk-stratification-of-pulmonary-nodules-in-multiple-endocrine-neoplasia-type-1
#13
Alvin So, Owen Pointon, Richard Hodgson, John Burgess
CONTEXT: Bronchopulmonary neuroendocrine tumours (bpNETs) and thymic carcinoid (ThC) are features of Multiple Endocrine Neoplasia Type 1 (MEN 1) and surveillance guidelines recommend periodic thoracic imaging. The optimal thoracic imaging modality and screening frequency remains uncertain as does the prognosis of small lung nodules when identified. OBJECTIVES: To evaluate fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) for identification and prognostic assessment of thoracic lesions in MEN 1...
February 15, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29446758/localized-thin-section-ct-with-radiomics-feature-extraction-and-machine-learning-to-classify-early-detected-pulmonary-nodules-from-lung-cancer-screening
#14
Shu-Ju Tu, Chih-Wei Wang, Kuang-Tse Pan, Yi-Cheng Wu, Chen-Te Wu
Lung cancer screening aims to detect small pulmonary nodules and decrease the mortality rate. However, studies from large-scale clinical trials of lung cancer screening showed false-positive rate is high and positive predictive value is low. To address these problems, it is highly needed to have a technical approach for accurate malignancy differentiation among these early-detected nodules. We studied the clinical feasibility of an additional protocol of localized thin-section CT for further assessment on these recalled patients from lung cancer screening tests...
February 15, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29445290/molecular-features-of-giant-cell-carcinoma-of-the-lung-a-case-report-and-literature-review
#15
Xin Li, Zihe Zhang, Jinghao Liu, Dan Wang, Sen Wei, Jun Chen
Giant-cell carcinoma of the lung (GCCL) is a rare histological form of poorly differentiated non-small-cell lung cancer, which is classified as a subtype of pulmonary sarcomatoid carcinomas. In this case report, we describe the case of a 50-year-old Chinese male who presented with a pulmonary nodule in the right upper lobe of his lung. After thoracoscopic lobectomy, a histopathologic diagnosis of GCCL was made. He did well postoperatively, showing no local recurrence or distal disease in a 7-year follow-up period...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29438443/visual-discrimination-of-screen-detected-persistent-from-transient-subsolid-nodules-an-observer-study
#16
Kaman Chung, Francesco Ciompi, Ernst T Scholten, Jin Mo Goo, Mathias Prokop, Colin Jacobs, Bram van Ginneken, Cornelia M Schaefer-Prokop
PURPOSE: To evaluate whether, and to which extent, experienced radiologists are able to visually correctly differentiate transient from persistent subsolid nodules from a single CT examination alone and to determine CT morphological features to make this differentiation. MATERIALS AND METHODS: We selected 86 transient and 135 persistent subsolid nodules from the National Lung Screening Trial (NLST) database. Four experienced radiologists visually assessed a predefined list of morphological features and gave a final judgment on a continuous scale (0-100)...
2018: PloS One
https://www.readbyqxmd.com/read/29437732/fatal-air-embolism-following-local-anaesthetisation-does-needle-size-matter
#17
Faiza Khalid, Sofiya Rehman, Rania AbdulRahman, Shikha Gupta
A 76--year--old male cigarette smoker presented with a 2-week history of cough and haemoptysis. Chest CT on admission revealed multiple new lung nodules concerning for malignancy. CT--guided biopsy of the nodule in left lower lobe was attempted in prone oblique position for tissue diagnosis. Local anaesthetic (lidocaine) was administered using a 25--gauge (1.5-inch) needle to anaesthetise the skin and subcutaneous tissue. This was followed by insertion of a 25-gauge (3.5-inch) Whitacre needle to anaesthetise deeper tissues and parietal pleura...
February 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29437031/underexpression-of-mir-486-5p-but-not-overexpression-of-mir-155-is-associated-with-lung-cancer-stages
#18
Marwa A Mohamed, Ehab I Mohamed, Samir A Abd El-Kaream, Mohamed I Badawi, Samy H Darwish
BACKGROUND: Evidence is increasing that microRNAs (miR) are particularly important in lung homeostasis and development and have been shown to be involved in many pulmonary diseases such as asthma, chronic obstructive pulmonary disease, sarcoidosis, lung cancer (LC) and other smoking-related diseases. OBJECTIVE: The objective of this study was to investigate the expression of miR-155 and miR-486-5p in tissues from LC patients and healthy endobronchial mucosa as prognostic biomarkers for diagnosing LC...
February 12, 2018: MicroRNA
https://www.readbyqxmd.com/read/29435285/significance-of-lung-biopsy-for-the-definitive-diagnosis-of-lung-nodules-in-breast-cancer-patients
#19
Kazuo Matsuura, Toshiyuki Itamoto, Midori Noma, Masahiro Ohara, Etsushi Akimoto, Mihoko Doi, Takashi Nishisaka, Koji Arihiro, Takayuki Kadoya, Morihito Okada
The aim of the present study was to evaluate the significance of lung biopsy for the modification of the treatment strategy in breast cancer patients who develop lung nodules during follow-up after breast surgery. Of 53 consecutive patients who underwent lung biopsies in two institutions (Hiroshima University Hospital and Hiroshima Prefectural Hospital, Hiroshima, Japan) between 1997 and 2014, 45 underwent lung surgery and 8 underwent percutaneous or transbronchial tumor biopsy for lung nodules developing after curative surgery for breast cancer...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29434948/granulocyte-colony-stimulating-factor-producing-mucinous-cystic-neoplasm-with-an-associated-invasive-carcinoma-of-the-pancreas
#20
Kazuhide Shimamatsu, Yoshiki Naito, Yutaro Mihara, Masamichi Nakayama, Masahiko Tanigawa, Yushi Abe, Ken Nakamura, Toshihiro Araki, Kenji Sakata, Kazunori Noguchi, Jun Akiba, Hirohisa Yano, Osamu Nakashima
The present case study documents an autopsy case of granulocyte-colony stimulating factor (G-CSF)-producing mucinous cystic neoplasm (MCN), with an associated invasive carcinoma of the pancreas. A 65-year-old woman presented to Omuta City Hospital (Omuta Japan) with a primary complaint of abdominal pain. Multiple liver nodules and a pancreatic cyst were detected upon abdominal computed tomography. Initially, liver abscess was suspected as the patient exhibited leukocytosis and elevated C-reactive protein level...
February 2018: Oncology Letters
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