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https://www.readbyqxmd.com/read/28526968/computer-aided-diagnosis-of-lung-nodules-in-computed-tomography-by-using-phylogenetic-diversity-genetic-algorithm-and-svm
#1
Antonio Oseas de Carvalho Filho, Aristófanes Corrêa Silva, Anselmo Cardoso de Paiva, Rodolfo Acatauassú Nunes, Marcelo Gattass
Lung cancer is pointed as the major cause of death among patients with cancer throughout the world. This work is intended to develop a methodology for diagnosis of lung nodules using images from the Image Database Consortium and Image Database Resource Initiative (LIDC-IDRI). The proposed methodology uses image processing and pattern recognition techniques. In order to differentiate between the patterns of malignant and benign nodules, we used phylogenetic diversity by means of particular indexes, that are: intensive quadratic entropy, extensive quadratic entropy, average taxonomic distinctness, total taxonomic distinctness, and pure diversity indexes...
May 19, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28523350/comparison-of-a-radiomic-biomarker-with-volumetric-analysis-for-decoding-tumour-phenotypes-of-lung-adenocarcinoma-with-different-disease-specific-survival
#2
Mei Yuan, Yu-Dong Zhang, Xue-Hui Pu, Yan Zhong, Hai Li, Jiang-Fen Wu, Tong-Fu Yu
OBJECTIVES: To compare a multi-feature-based radiomic biomarker with volumetric analysis in discriminating lung adenocarcinomas with different disease-specific survival on computed tomography (CT) scans. METHODS: This retrospective study obtained institutional review board approval and was Health Insurance Portability and Accountability Act (HIPAA) compliant. Pathologically confirmed lung adenocarcinoma (n = 431) manifested as subsolid nodules on CT were identified...
May 18, 2017: European Radiology
https://www.readbyqxmd.com/read/28523171/uniportal-video-assisted-thoracoscopic-combined-segmentectomy-for-lung-cancer-with-incomplete-fissure
#3
Ding-Pei Han, Kai Chen, Ya-Jie Zhang, Dan-Nong He, He-Cheng Li
This video clip demonstrated a performance of uniportal video-assisted thoracoscopic surgery combined segmentectomy. The patient had a potential invasive nodule located near the bifurcation of right bronchus, 3-dimensional reconstruction image showed the fissure between posterior segment of upper lobe and superior segment of lower lobe was incomplete. An up-to-down approach was applied in this operation with the en bloc resection of the two segments. Pathological report was adenocarcinoma with negative margin (TNM stage: T1aN0M0)...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28523166/a-novel-hybrid-technique-for-localization-of-subcentimeter-lung-nodules
#4
Xuguang Pang, Liang Xue, Jiemin Chen, Jianyong Ding
BACKGROUND: It is technically challenging to locate non-visible, non-palpable subcentimeter ground-glass nodules (GGNs) of lung during video-assisted thoracic surgery (VATS). Computed tomography (CT)-guided marking of small pulmonary nodules using microcoils has been reported to be a practical method of preoperative localization, whereas dislodgement of microcoils remains to be a bothersome complication. The objective of this study was to assess the viability and effectiveness of a newly developed hybrid technique, which combines induced controllable pneumothorax and CT-guided microcoil marking procedure to reduce the risk of microcoil dislodgement...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28523157/impact-of-maximum-standardized-uptake-value-of-non-small-cell-lung-cancer-on-detecting-lymph-node-involvement-in-potential-stereotactic-body-radiotherapy-candidates
#5
Shanyuan Zhang, Shaolei Li, Yuquan Pei, Miao Huang, Fangliang Lu, Qingfeng Zheng, Nan Li, Yue Yang
BACKGROUND: The retrospective study investigated the association between the maximum standardized uptake value (SUVmax) of primary tumor and lymph node involvement in potential stereotactic body radiotherapy (SBRT) candidates. METHODS: A total of 185 patients with clinical stage I NSCLC were enrolled in the current study. All patients underwent lobectomy with systematic lymph node dissection following preoperative FDG-PET/CT scanning. The association between clinicopathological variables and lymph node involvement was analyzed by univariate and multivariate analysis...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28522279/-stereotactic-lung-radiotherapy-technical-setting-up-on-novalis-tx-%C3%A2-and-single-centre-prospective-study-of-the-100-first-malignant-pulmonary-nodules-treated-at-centre-jean-perrin
#6
A Bellière-Calandry, G Dupic, F Magnier, V Chassin, V Dedieu, M Lapeyre
PURPOSE: Description of the treatment technique of stereotactic lung radiotherapy on Novalis Tx(®) and prospective study of the first 100 pulmonary nodules treated at centre Jean-Perrin (France). MATERIAL AND METHODS: From October 2012 to December 2015, 100 inoperable pulmonary nodules (62 stage I non-small-cell lung cancer and 38 metastases) of 90 patients with a mean age of 68.2 years (range: 46-89 years) were prospectively treated with dynamic arctherapy on Novalis Tx(®)...
May 15, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28521651/miliary-metastases-are-associated-with-epidermal-growth-factor-receptor-mutations-in-non-small-cell-lung-cancer-a-population-based-study
#7
Fred Hsu, Alan Nichol, Ted Toriumi, Alex De Caluwe
BACKGROUND: Miliary metastases are characterized by metastatic nodules that are diffuse, innumerable and small. The purpose of this study was to examine the incidence, prognostic significance and impact of epidermal growth factor receptor (EGFR) mutations for miliary metastases from non-small cell lung cancer (NSCLC). MATERIAL AND METHODS: Patients were identified from a Provincial cancer registry (British Columbia, Canada) for the period 2010-2012. Inclusion criteria were stage IV NSCLC at presentation and conclusive EGFR mutation testing...
May 19, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28516395/thoracoscopic-partial-resection-without-using-a-stapler-complete-republication
#8
Toshiya Toyazaki, Yasuaki Tomioka, Naohisa Chiba, Yuichiro Ueda, Yasuto Sakaguchi, Masashi Gotoh, Shinya Ishikawa, Tatsuo Nakagawa
Thoracoscopic partial pulmonary resection for small peripheral nodules without using a stapler has been introduced to our hospital. After partial resection was performed with electrocautery, two different methods of surface sealing were used: a coagulation method (C method) with Soft Coagulation alone, and a coagulation-suturing method (CS method) with Soft Coagulation combined with continuous suturing. The clinical outcomes of the two methods were retrospectively compared in this study. The C method was used in 19 lesions of 18 cases, and the CS method was used in 20 lesions of 19 cases...
May 17, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28515042/radiology-in-diffuse-parenchymal-lung-disease-and-lung-nodules
#9
EDITORIAL
Nicola Sverzellati, Sujal Desai
No abstract text is available yet for this article.
June 30, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28512000/computed-tomography-ct-compatible-remote-center-of-motion-needle-steering-robot-fusing-ct-images-and-electromagnetic-sensor-data
#10
Navid Shahriari, Wout Heerink, Tim van Katwijk, Edsko Hekman, Matthijs Oudkerk, Sarthak Misra
Lung cancer is the most common cause of cancer-related death, and early detection can reduce the mortality rate. Patients with lung nodules greater than 10 mm usually undergo a computed tomography (CT)-guided biopsy. However, aligning the needle with the target is difficult and the needle tends to deflect from a straight path. In this work, we present a CT-compatible robotic system, which can both position the needle at the puncture point and also insert and rotate the needle. The robot has a remote-center-of-motion arm which is achieved through a parallel mechanism...
May 13, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28505359/thoracoscopic-anatomical-lung-segmentectomy-using-3d-computed-tomography-simulation-without-tumour-markings-for-non-palpable-and-non-visualized-small-lung-nodules%C3%A2
#11
Hirohisa Kato, Hiroyuki Oizumi, Jun Suzuki, Akira Hamada, Hikaru Watarai, Mitsuaki Sadahiro
OBJECTIVES: Although wedge resection can be curative for small lung tumours, tumour marking is sometimes required for resection of non-palpable or visually undetectable lung nodules as a method for identification of tumours. Tumour marking sometimes fails and occasionally causes serious complications. We have performed many thoracoscopic segmentectomies using 3D computed tomography simulation for undetectable small lung tumours without any tumour markings. The aim of this study was to investigate whether thoracoscopic segmentectomy planned with 3D computed tomography simulation could precisely remove non-palpable and visually undetectable tumours...
May 12, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28503520/pulmonary-sarcoidosis-that-developed-during-the-treatment-of-a-patient-with-crohn-disease-by-using-infliximab
#12
Tae Kyun Kim, Sun Hyung Kang, Hee Seok Moon, Jae Kyu Sung, Hyun Yong Jeong, Hyuk Soo Eun
For inflammatory bowel disease (IBD), antitumor necrosis factor treatment offers a new direction for both patients and medical doctors. This treatment has dramatically improved the quality of life for patients with ulcerative colitis and Crohn disease (CD). However, with increasing usage and longer follow-up periods, a wider range of possible adverse effects may be encountered. We report an unusual case of pulmonary sarcoidosis developed during the treatment of a patient with CD by using infliximab. A 30-year-old male who had been treated for CD with infliximab for 18 months was admitted due to abnormal opacities on chest radiography...
April 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/28503304/clinico-pathologic-presentation-of-hypersensitivity-pneumonitis-in-egyptian-patients-a-multidisciplinary-study
#13
Dalia Abd El-Kareem, Yosri M Akl, Gina A Nakhla, Ali A Elhindawi, Mahmoud A Eltorky
BACKGROUND: Hypersensitivity pneumonitis (HP) is a common diffuse parenchymal lung disease in Egypt which can be difficult to recognize due to the dynamic symptoms & associated environmental factors. METHODS: Forty-three Egyptian patients were enrolled in this study, presenting with dyspnea and cough, predominant ground-glass opacity (GGO) in high-resolution computed tomography (HRCT) where lung biopsy was needed to establish the diagnosis. RESULTS: The age range was 15 to 60 years...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28501942/pulmonary-nodule-classification-with-deep-residual-networks
#14
Aiden Nibali, Zhen He, Dennis Wollersheim
PURPOSE  : Lung cancer has the highest death rate among all cancers in the USA. In this work we focus on improving the ability of computer-aided diagnosis (CAD) systems to predict the malignancy of nodules from cropped CT images of lung nodules. METHODS: We evaluate the effectiveness of very deep convolutional neural networks at the task of expert-level lung nodule malignancy classification. Using the state-of-the-art ResNet architecture as our basis, we explore the effect of curriculum learning, transfer learning, and varying network depth on the accuracy of malignancy classification...
May 13, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28498365/inhibition-of-twist1-mediated-invasion-by-chk2-promotes-premature-senescence-in-p53-defective-cancer-cells
#15
Debasis Nayak, Anmol Kumar, Souneek Chakraborty, Reyaz Ur Rasool, Hina Amin, Archana Katoch, Veena Gopinath, Vidushi Mahajan, Mahesh K Zilla, Bilal Rah, Sumit G Gandhi, Asif Ali, Lekha Dinesh Kumar, Anindya Goswami
Twist1, a basic helix-loop-helix transcription factor is implicated as a key mediator of epithelial-mesenchymal transition (EMT) and metastatic dissemination in p53-deficient cancer cells. On the other hand, checkpoint kinase 2 (Chk2), a major cell cycle regulatory protein provides a barrier to tumorigenesis due to DNA damage response by preserving genomic stability of the cells. Here we demonstrate that Chk2 induction proficiently abrogates invasion, cell scattering and invadopodia formation ability of p53-mutated invasive cells by suppressing Twist1, indicating Chk2 confers vital role in metastasis prevention...
May 12, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28496082/-slowly-progressive-basaloid-squamous-cell-carcinoma-of-the-lung
#16
Kazuma Kobayashi, Koutaro Abe, Naoya Ishibashi, Nobuyuki Sato, Yoshinori Okada
Basaloid squamous cell carcinoma (BSC) of the lung is a rare variant of squamous cell carcinoma (SCC) and is reported to show poor prognosis. A 70-year-old man presented to the clinic complaining of a productive cough. Computed tomography( CT) of the chest revealed a nodule in the left lower lobe of the lung. A bronchoscopy and transbronchial lung biopsy(TBB) were performed twice;no evidence of malignancy was found. So we followed up by periodic chest CT. One year and 4 months after the 1st visit, the nodule increased in size from 14 to 19 mm...
May 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28495060/hot-nodules-and-histologic-features-the-emerging-story-of-stage-ia-lung-adenocarcinoma
#17
EDITORIAL
Yusuke Takahashi, Prasad S Adusumilli
No abstract text is available yet for this article.
April 19, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28495056/a-novel-minimally-invasive-near-infrared-thoracoscopic-localization-technique-of-small-pulmonary-nodules-a-phase-i-feasibility-trial
#18
Hideki Ujiie, Tatsuya Kato, Hsin-Pei Hu, Priya Patel, Hironobu Wada, Kosuke Fujino, Robert Weersink, Elsie Nguyen, Marcelo Cypel, Andrew Pierre, Marc de Perrot, Gail Darling, Thomas K Waddell, Shaf Keshavjee, Kazuhiro Yasufuku
OBJECTIVES: Localization and resection of nonvisible, nonpalpable pulmonary nodules during video-assisted thoracoscopic surgery are challenging. Our study was to determine the feasibility and safety of indocyanine green fluorescence localization and resection of small nodules using a near-infrared fluorescence thoracoscope. METHODS: Twenty patients with undiagnosed peripheral nodules smaller than 3 cm scheduled for computed tomography-guided microcoil placement followed by video-assisted thoracoscopic surgery wedge resection were enrolled...
April 13, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28494836/pulmonary-toxicity-in-rats-caused-by-exposure-to-intratracheal-instillation-of-sio2-nanoparticles
#19
Hong Yang, Qiu Yun Wu, Ming Yue Li, Can Shan Lao, Ying Jian Zhang
OBJECTIVE: The effect of the silica nanoparticles (SNs) on lungs injury in rats was investigated to evaluate the toxicity and possible mechanisms for SNs. METHODS: Male Wistar rats were instilled intratracheally with 1 mL of saline containing 6.25, 12.5, and 25.0 mg of SNs or 25.0 mg of microscale SiO2 particles suspensions for 30 d, were then sacrificed. Histopathological and ultrastructural change in lungs, and chemical components in the urine excretions were investigated by light microscope, TEM and EDS...
April 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28494807/concordant-clear-cell-mesonephric-carcinoma-of-the-bladder-and-lung-adenocarcinoma-with-clear-cell-features-multiple-primaries-versus-metastatic-neoplasms-a-case-report
#20
Sarmad H Jassim, Amer Khiyami, Jane K Nguyen, Santhi Ganesan, Joseph Tomashefski, Joram Sawady
BACKGROUND: Clear cell carcinoma of the bladder is a rare variant of urinary bladder adenocarcinoma. We report a case of a patient with clear cell carcinoma of the bladder and a concordant right upper lobe pulmonary adenocarcinoma with clear cell features, and we address the role of immunohistochemistry and cytogenetic analysis in distinguishing the two primary malignancies. CASE PRESENTATION: Our patient was a 59-year-old African American woman who presented with hematuria...
May 12, 2017: Journal of Medical Case Reports
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