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https://www.readbyqxmd.com/read/29667749/effect-of-lysm-macrophage-depletion-on-lung-pathology-in-mice-with-chronic-bronchitis
#1
Yogesh Saini, Brandon W Lewis, Dongfang Yu, Hong Dang, Alessandra Livraghi-Butrico, Fabio Del Piero, Wanda K O'Neal, Richard C Boucher
Macrophages (MΦ) are key sentinels of respiratory exposure to inhaled environmental stimuli. In normal "healthy" tissues, MΦ are believed to be a dormant cell type that, upon exposure to stress-causing stimuli, may get activated to exhibit pro- or anti-inflammatory roles. To test whether stress present in chronic bronchitic (CB) airways triggers MΦ to manifest protective or detrimental responses, the DTA+ (LysM-regulated Diphtheria Toxin A expressing) strain with partial MΦ-deficiency was crossed with the Scnn1b-Tg mouse model of CB and the progenies were studied at 4-5 weeks of age...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29666814/digital-chest-tomosynthesis-the-2017-updated-review-of-an-emerging-application
#2
REVIEW
Arianna Ferrari, Luca Bertolaccini, Piergiorgio Solli, Paola Oriana Di Salvia, David Scaradozzi
Lung cancer is the leading cause of cancer death and second most common cancer among both men and women, but most of them are detected when patients become symptomatic and in late-stage. Chest radiography (CR) is a basic technique for the investigation of lung cancer and has the benefit of convenience and low radiation dose, but detection of malignancy is often difficult. The introduction of computed tomography (CT) for screening has increased the proportion of lung cancer detected but with higher exposure dose and higher costs...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29664842/incidental-thoracic-findings-on-routine-computed-tomography-in-epithelial-ovarian-cancer
#3
Bobby D OʼLeary, Teresa Treacy, Tony Geoghegan, Tom A Walsh, William D Boyd, Donal J Brennan
INTRODUCTION: Multidetector computed tomography (MDCT) is routinely used in the surveillance of epithelial ovarian cancer. The aim of this study was to determine the incidence of thoracic findings on routine MDCT surveillance imaging in patients with ovarian carcinoma. MATERIALS AND METHODS: Retrospective evaluation of 100 MDCT studies of patients with a diagnosis of epithelial ovarian cancer was performed at a university teaching hospital. The cross-sectional studies were reviewed by a consultant radiologist with subspeciality training in cross-sectional imaging...
April 16, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29664761/initial-clinical-experience-with-a-flexible-peripheral-21-g-needle-device
#4
Alain Tremblay, Renelle Myers, Eve-Lea Beaudoin, Martina Bonifazi, Antoine Delage, Marc Fortin, Christopher A Hergott, Paul R MacEachern, Tawimas Shaipanich, Benjamin Shieh, Stefano Gasparini, Stephen Lam
BACKGROUND: Bronchoscopic techniques can be used to safely sample peripheral lung nodules (PLN), and transbronchial needle aspiration (TBNA) can further increase the diagnostic yield. Current needle devices not necessarily designed for this indication have limitations. We report our initial experience with a new flexible nitinol peripheral TBNA needle specifically designed for such sampling. METHODS: Retrospective case review describing the first clinical cases performed with a commercially available 21-G peripheral TBNA device in 4 centers...
April 16, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29661918/characteristics-of-new-solid-nodules-detected-in-incidence-screening-rounds-of-low-dose-ct-lung-cancer-screening-the-nelson-study
#5
Joan E Walter, Marjolein A Heuvelmans, Geertruida H de Bock, Uraujh Yousaf-Khan, Harry J M Groen, Carlijn M van der Aalst, Kristiaan Nackaerts, Peter M A van Ooijen, Harry J de Koning, Rozemarijn Vliegenthart, Matthijs Oudkerk
PURPOSE: New nodules after baseline are regularly found in low-dose CT lung cancer screening and have a high lung cancer probability. It is unknown whether morphological and location characteristics can improve new nodule risk stratification by size. METHODS: Solid non-calcified nodules detected during incidence screening rounds of the randomised controlled Dutch-Belgian lung cancer screening (NELSON) trial and registered as new or previously below detection limit (15 mm3 ) were included...
April 16, 2018: Thorax
https://www.readbyqxmd.com/read/29661040/use-of-augmented-fluoroscopic-imaging-during-diagnostic-bronchoscopy
#6
D Kyle Hogarth
The single pulmonary nodule evaluation is a complex problem. In particular, attempts to biopsy peripheral nodules with bronchoscopy have been hampered by difficulty navigating to the correct airway and then confirming the instruments' proximity to the nodule. Virtual systems in use do not provide real-time feedback of a live image of the nodule in question. Fluoroscopy has traditionally offered limited assistance as often the nodule is not visible and provides no information on airways/pathways to the nodule...
April 17, 2018: Future Oncology
https://www.readbyqxmd.com/read/29659330/treatment-of-stage-iv-favorable-histology-wilms-tumor-with-lung-metastases-a-report-from-the-children-s-oncology-group-aren0533-study
#7
David B Dix, Nita L Seibel, Yueh-Yun Chi, Geetika Khanna, Eric Gratias, James R Anderson, Elizabeth A Mullen, James I Geller, John A Kalapurakal, Arnold C Paulino, Elizabeth J Perlman, Peter F Ehrlich, Marcio Malogolowkin, Julie M Gastier-Foster, Elizabeth Wagner, Paul E Grundy, Conrad V Fernandez, Jeffrey S Dome
Purpose The National Wilms Tumor Study (NWTS) treatment of favorable histology Wilms tumor with lung metastases was vincristine/dactinomycin/doxorubicin (DD4A) and lung radiation therapy (RT). The AREN0533 study applied a new risk stratification and treatment strategy to improve event-free survival (EFS) while reducing exposure to lung RT. Methods Patients with favorable histology Wilms tumor and isolated lung metastases showing complete lung nodule response (CR) after 6 weeks of DD4A continued receiving chemotherapy without lung RT...
April 16, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29659181/combination-of-anginex-gene-therapy-and-radiation-decelerates-the-growth-and-pulmonary-metastasis-of-human-osteosarcoma-xenografts
#8
Kai Zhao, Shang-You Yang, Jun Geng, Xuan Gong, Weiming Gong, Lin Shen, Bin Ning
Investigate whether rAAV-anginex gene therapy combined with radiotherapy could decrease growth and pulmonary metastasis of osteosarcoma in mice and examine the mechanisms involved in this therapeutic strategy. During in vitro experiment, multiple treatment regimes (rAAV-eGFP, radiotherapy, rAAV-anginex, combination therapy) were applied to determine effects on proliferation of endothelial cells (ECs) and G-292 osteosarcoma cells. During in vivo analysis, the same multiple treatment regimes were applied to osteosarcoma tumor-bearing mice...
April 16, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29658011/a-listeria-derived-polypeptide-promotes-in-vivo-activation-of-nk-cells-for-antitumor-therapy
#9
Amber L Ortiz, Laurel L Lenz
Immunotherapies have shown promise in treatment of cancer, but more potent and targeted therapies are needed. Natural killer (NK) cells are lymphocytes with innate ability to recognize and lyse tumor cells. When activated, they also produce type II interferon (IFNγ) to orchestrate the activity of other immune cells. Strategies to elicit NK cell activation in vivo have potential usefulness in anti-tumor immunotherapies. Here, we report on a strategy to stimulate NK cell activation and anti-tumor activity in mice with established B16...
June 1, 2017: ImmunoHorizons
https://www.readbyqxmd.com/read/29656749/tumor-associated-macrophages-support-the-growth-of-fgf9-induced-lung-adenocarcinoma-by-multiple-mechanisms
#10
Ahmed E Hegab, Mari Ozaki, Shizuko Kagawa, Junko Hamamoto, Hiroyuki Yasuda, Katsuhiko Naoki, Kenzo Soejima, Yongjun Yin, Tomonari Kinoshita, Tomonori Yaguchi, Yutaka Kawakami, David M Ornitz, Tomoko Betsuyaku
OBJECTIVES: Tumor-associated macrophages (TAMs) are known to promote tumorigenesis but the mechanism(s) remain elusive. We have developed a mouse model of lung cancer that is initiated through an inducible overexpression of fibroblast growth factor 9 (FGF9) in type-2 pneumocytes. Expression of FGF9 in adult lungs resulted in a rapid development of multiple adenocarcinoma-like tumor nodules, and is associated with an intense immunological reaction. The purpose of this study is to characterize the immune response to the FGF9-induced lung adenocarcinoma and to determine the contribution of TAMs to growth and survival of these tumors...
May 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29652577/lung-cancers-associated-with-cystic-airspaces-underrecognized-features-of-early-disease
#11
Sarah Sheard, Joanna Moser, Charlie Sayer, Konstantinos Stefanidis, Anand Devaraj, Ioannis Vlahos
Early lung cancers associated with cystic airspaces are increasingly being recognized as a cause of delayed diagnoses-owing to data gathered from screening trials and encounters in routine clinical practice as more patients undergo serial imaging. Several morphologic subtypes of cancers associated with cystic airspaces exist and can exhibit variable patterns of progression as the solid elements of the tumor grow. Current understanding of the pathogenesis of these malignancies is limited, and the numbers of cases reported in the literature are small...
April 13, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29651817/two-cases-of-chloromethylisothiazolinone-and-methylisothiazolinone-associated-toxic-lung-injury
#12
Eun Lee, Seung Kook Son, Jisun Yoon, Hyun Ju Cho, Song I Yang, Sungsu Jung, Kyung Hyun Do, Young Ah Cho, So Yeon Lee, Dong Uk Park, Soo Jong Hong
Previous animal studies have not conclusively determined the association between exposure to humidifier disinfectants (HDs) containing 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and/or 2-methyl-4-isothiazolin-3-one (MIT) and development of HD-associated lung injuries. Nonetheless, patients exposed to HDs containing only CMIT and/or MIT showed clinically similar lung injuries to those exposed to HDs containing polyhexamethylene guanidine (PHMG) or oligo (2-[2-ethoxy]ethoxyethyl) guanidinium chloride (PGH)...
April 16, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29650917/-a-case-of-primary-spinddle-cell-carcinoma-of-the-breast
#13
Hiroshi Kawai, Chihiro Yoshikawa, Kento Kawasaki, Norichika Iga, Ryosuke Yoshida, Naohisa Waki, Futoshi Uno, Masahiro Ishizaki, Hideyuki Nishi, Kazuki Yamashita, Shinichiro Miyoshi
A 76-year-old female underwent breast-conserving surgery of the right breast and sentinel lymph node biopsy for primary breast cancer. Three years later, mammography and ultrasonography showed a small nodule in the right breast. There was nothing abnormal in the left breast. Three months later, she complained of a huge and rapid growing mass in the left breast. Malignant cells were obtained on fine needle aspiration biopsy in the right breast tumor. But it was not possible to diagnose whether the left breast tumor was benign or malignant on fine needle aspiration biopsy and needle biopsy...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650547/-in-vivo-growth-of-60-non-screening-detected-lung-cancers-a-computed-tomography-study
#14
Onno M Mets, Kaman Chung, Pieter Zanen, Ernst T Scholten, Wouter B Veldhuis, Bram van Ginneken, Mathias Prokop, Cornelia M Schaefer-Prokop, Pim A de Jong
Current pulmonary nodule management guidelines are based on nodule volume doubling time, which assumes exponential growth behaviour. However, this is a theory that has never been validated in vivo in the routine-care target population. This study evaluates growth patterns of untreated solid and subsolid lung cancers of various histologies in a non-screening setting.Growth behaviour of pathology-proven lung cancers from two academic centres that were imaged at least three times before diagnosis (n=60) was analysed using dedicated software...
April 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29644341/uptake-of-99m-tc-mibi-by-sclerosing-pneumocytoma-raising-a-false-suspicion-of-metastasis-from-medullary-thyroid-carcinoma
#15
Georgios E Papadakis, Flavian Tabotta, Igor Levotanec, Michel Gonzalez, John O Prior, Stefano La Rosa, Gerasimos P Sykiotis
Technetium-99m methoxy isobutyl isonitrile (99m Tc-MIBI; sestamibi) single-photon emission computed tomography (SPECT)/computed tomography (CT) performed for preoperative localization of parathyroid adenomas or for other indications can reveal incidentalomas. Interpretation of such findings can be challenging, particularly when thyroid or other endocrine tumors are also present. Preoperative staging of a 59-year-old female patient with medullary thyroid carcinoma (MTC) showing moderate hypermetabolism on 18 F-fluorodeoxyglucose positron emission tomography/CT also detected a slightly hypermetabolic pulmonary nodule (standardized uptake value normalized by body weight max = 2...
April 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29627084/one-lung-flooding-enables-ultrasound-guided-transthoracic-needle-biopsy-of-pulmonary-nodules-with-high-sensitivity
#16
Thomas Günter Lesser, Iver Petersen, Frank Pölzing, Frank Wolfram
Ultrasound-guided transthoracic needle biopsy (USgTTNB) can only be used for peripheral tumours that contact the pleura. Sonographic accessibility of the entire lung can be achieved using one-lung flooding. In this study, feasibility, sensitivity and complication rate of USgTTNB of lung nodules after one-lung flooding in an ex vivo and in vivo lung tumour model were assessed. USgTTNB was performed ex vivo after one-lung flooding in 10 resected human lung lobes containing carcinoma or metastasis. USgTTNB after one-lung flooding and simulation of a lung nodule was conducted in vivo in 5 animals...
April 4, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29626973/a-64-year-old-woman-with-an-incidental-pulmonary-nodule
#17
Farah Kazzaz, Sujith V Cherian, Xiaohong Wang, Shahreen Billah, Rosa M Estrada-Y-Martin
A 64-year-old Latin American woman was referred for evaluation of an incidental pulmonary nodule. She had originally presented to her primary care physician with complaints of abdominal pain warranting a CT scan of the abdomen, which revealed a right lower lobe pulmonary nodule. She denied any complaints of shortness of breath or cough. Review of systems was unremarkable and medical history was significant for hypertension only. She also denied primary or secondary tobacco exposure or any recreational drug abuse...
April 2018: Chest
https://www.readbyqxmd.com/read/29622078/update-of-mr-imaging-for-evaluation-of-lung-cancer
#18
REVIEW
Mario Ciliberto, Yuji Kishida, Shinichiro Seki, Takeshi Yoshikawa, Yoshiharu Ohno
Since MR imaging was introduced for the assessment of thoracic and lung diseases, various limitations have hindered its widespread adoption in clinical practice. Since 2000, various techniques have been developed that have demonstrated the usefulness of MR imaging for lung cancer evaluation, and it is now reimbursed by health insurance companies in many countries. This article reviews recent advances in lung MR imaging, focusing on its use for lung cancer evaluation, especially with regard to pulmonary nodule detection, pulmonary nodule and mass assessment, lung cancer staging and detection of recurrence, postoperative lung function prediction, and therapeutic response evaluation and prediction...
May 2018: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/29622073/lung-cancer-biopsies
#19
REVIEW
Amita Sharma, Jo-Anne O Shepard
Image-guided percutaneous transthoracic needle biopsy (PTNB) is a well-established and minimally invasive technique for evaluating pulmonary nodules. Implementation of a national lung screening program and increased use of chest computed tomography have contributed to the frequent identification of indeterminate pulmonary nodules that may require tissue sampling. The advent of biomarker-driven lung cancer therapy has led to increased use of repeat PTNB after diagnosis. Percutaneous insertion of markers for preoperative localization of small nodules can aid in minimally invasive surgery and radiation treatment planning...
May 2018: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/29622071/pulmonary-nodule-management-in-lung-cancer-screening-a-pictorial-review-of-lung-rads-version-1-0
#20
REVIEW
Myrna C B Godoy, Erika G L C Odisio, Mylene T Truong, Patricia M de Groot, Girish S Shroff, Jeremy J Erasmus
The number of screening-detected lung nodules is expected to increase as low-dose computed tomography screening is implemented nationally. Standardized guidelines for image acquisition, interpretation, and screen-detected nodule workup are essential to ensure a high standard of medical care and that lung cancer screening is implemented safely and cost effectively. In this article, we review the current guidelines for pulmonary nodule management in the lung cancer screening setting.
May 2018: Radiologic Clinics of North America
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