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https://www.readbyqxmd.com/read/28527248/-clinical-and-demographic-profile-and-risk-factors-for-clostridium-difficile-infection
#1
Carlos Carvajal, Carlos Pacheco, Fabián Jaimes
INTRODUCTION: Clostridium difficile infection is the leading cause of nosocomial infectious diarrhea. The increasing incidence added to a lower rate of response to the initial treatment and higher rates of relapse has generated a higher burden of the disease. OBJECTIVE: To determine the clinical characteristics of hospitalized patients with C. difficile infection. MATERIALS AND METHODS: We made a nested case-cohort study. We reviewed medical records of the patients with nosocomial diarrhea for whom an assay for toxin A-B of C...
January 24, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28520887/apolipoprotein-c-iii-and-high-density-lipoprotein-subspecies-defined-by-apolipoprotein-c-iii-in-relation-to-diabetes-risk
#2
Sarah A Aroner, Ming Yang, Junlong Li, Jeremy D Furtado, Frank M Sacks, Anne Tjønneland, Kim Overvad, Tianxi Cai, Majken K Jensen
Apolipoprotein C-III (apoC-III) is a potential novel biomarker that may play an important role in the pathogenesis of diabetes, particularly when present on high-density lipoprotein (HDL). In a case-cohort design among 3,101 non-cases and 434 incident diabetes cases occurring before 2007 in the Danish Diet, Cancer, and Health study, we examined associations of baseline (1993-1997) plasma concentrations of apoC-III and subspecies of HDL defined by the presence or absence of apoC-III with risk of diabetes using Cox regression...
May 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28515065/neonatal-vitamin-d-status-from-archived-dried-blood-spots-and-future-risk-of-fractures-in-childhood-results-from-the-d-tect-study-a-population-based-case-cohort-study
#3
Mina Nicole Händel, Peder Frederiksen, Arieh Cohen, Cyrus Cooper, Berit Lilienthal Heitmann, Bo Abrahamsen
Background: Whether antenatal and neonatal vitamin D status have clinical relevance in fracture prevention has not been examined extensively, although observational studies indicate that fetal life may be a sensitive period in relation to bone growth and mineralization during childhood.Objective: We examined whether 25-hydroxyvitamin D3 [25(OH)D3] concentrations in stored neonatal dried blood spot (DBS) samples are associated with pediatric fracture risk. We hypothesized that in particular, low neonatal vitamin D status may be a risk factor for fracture incidence among children...
May 17, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28472285/associations-of-vitamin-d-binding-globulin-and-bioavailable-vitamin-d-concentrations-with-coronary-heart-disease-events-the-multi-ethnic-study-of-atherosclerosis-mesa
#4
Cassianne Robinson-Cohen, Leila R Zelnick, Andrew N Hoofnagle, Pamela L Lutsey, Gregory Burke, Erin D Michos, Steven J C Shea, Russell Tracy, David S Siscovick, Bruce Psaty, Bryan Kestenbaum, Ian H de Boer
Context: Low 25-hydroxyvitamin D (25(OH)D) is associated with a greater risk of coronary heart disease (CHD) in individuals who are white and Chinese, but not black or Hispanic. Vitamin D binding globulin (VDBG) avidly binds 25(OH)D, reducing its bioavailability, and differs in isoform and concentration by race/ethnicity. Objective: Evaluate associations of VDBG with CHD and whether accounting for VDBG or estimating bioavailable 25(OH)D explains the racial heterogeneity of the association of serum 25(OH)D with CHD...
May 3, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28467457/a-prognostic-model-for-development-of-significant-liver-fibrosis-in-hiv-hepatitis-c-co-infection
#5
Nasheed Moqueet, Cynthia Kanagaratham, M John Gill, Mark Hull, Sharon Walmsley, Danuta Radzioch, Sahar Saeed, Robert W Platt, Marina B Klein
BACKGROUND: Liver fibrosis progresses rapidly in HIV-Hepatitis C virus (HCV) co-infected individuals partially due to heightened inflammation. Immune markers targeting stages of fibrogenesis could aid in prognosis of fibrosis. METHODS: A case-cohort study was nested in the prospective Canadian Co-infection Cohort (n = 1119). HCV RNA positive individuals without fibrosis, end-stage liver disease or chronic Hepatitis B at baseline (n = 679) were eligible. A random subcohort (n = 236) was selected from those eligible...
2017: PloS One
https://www.readbyqxmd.com/read/28448975/validation-of-a-case-finding-algorithm-for-hidradenitis-suppurativa-using-administrative-coding-from-a-clinical-database
#6
Andrew Strunk, Margaretta Midura, Vassiliki Papagermanos, Allireza Alloo, Amit Garg
BACKGROUND: Requisite to the application of clinical databases for observational research in hidradenitis suppurativa (HS) is the identification of an accurate case cohort. OBJECTIVE: To assess the validity of utilizing administrative codes to establish the HS cohort from a large clinical database. METHODS: In this retrospective study using chart review as the reference standard, we calculated several estimates of the diagnostic accuracy of at least 1 ICD-9 code for HS...
April 28, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28444001/birth-weight-and-risk-of-childhood-solid-tumors-in-brazil-a-record-linkage-between-population-based-data-sets
#7
Neimar de Paula Silva, Rejane de Souza Reis, Rafael Garcia Cunha, Julio Fernando Oliveira, Fernanda Cristina da Silva de Lima, Maria Socorro Pombo-de-Oliveira, Marceli Oliveira Santos, Beatriz de Camargo
Objective: To analyze the relationship between the development of childhood solid tumors and 1) birth weight and 2) fetal growth, using two Brazilian population-based data sets. Methods: A case-cohort study was performed using two population-based data sets, and linkage between the Live Birth Information System (Sistema de Informação sobre Nascidos Vivos, SINASC) and 14 population-based cancer registries (PBCRs) was established. Four controls per case were chosen randomly from the SINASC data set...
April 20, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28434945/prognostic-biomarker-identification-through-integrating-the-gene-signatures-of-hepatocellular-carcinoma-properties
#8
Jialin Cai, Bin Li, Yan Zhu, Xuqian Fang, Mingyu Zhu, Mingjie Wang, Shupeng Liu, Xiaoqing Jiang, Jianming Zheng, XinXin Zhang, Peizhan Chen
Many molecular classification and prognostic gene signatures for hepatocellular carcinoma (HCC) patients have been established based on genome-wide gene expression profiling; however, their generalizability is unclear. Herein, we systematically assessed the prognostic effects of these gene signatures and identified valuable prognostic biomarkers by integrating these gene signatures. With two independent HCC datasets (GSE14520, N=242 and GSE54236, N=78), 30 published gene signatures were evaluated, and 11 were significantly associated with the overall survival (OS) of postoperative HCC patients in both datasets...
April 12, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28428221/circulating-levels-of-interleukin-1-receptor-antagonist-and-risk-of-cardiovascular-disease-meta-analysis-of-six-population-based-cohorts
#9
Christian Herder, Tonia de Las Heras Gala, Maren Carstensen-Kirberg, Cornelia Huth, Astrid Zierer, Simone Wahl, Julie Sudduth-Klinger, Kari Kuulasmaa, David Peretz, Symen Ligthart, Brenda W C Bongaerts, Abbas Dehghan, M Arfan Ikram, Antti Jula, Frank Kee, Arto Pietilä, Olli Saarela, Tanja Zeller, Stefan Blankenberg, Christa Meisinger, Annette Peters, Michael Roden, Veikko Salomaa, Wolfgang Koenig, Barbara Thorand
OBJECTIVE: Interleukin (IL)-1β represents a key cytokine in the development of cardiovascular disease (CVD). IL-1β is counter-regulated by IL-1 receptor antagonist (IL-1RA), an endogenous inhibitor. This study aimed to identify population-based studies on circulating IL-1RA and incident CVD in a systematic review, estimate the association between IL-1RA and incident CVD in a meta-analysis, and to test whether the association between IL-1RA and incident CVD is explained by other inflammation-related biomarkers in the MONICA/KORA Augsburg case-cohort study (Multinational Monitoring of Trends and Determinants in Cardiovascular Disease/Cooperative Health Research in the Region of Augsburg)...
April 20, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28420543/serum-persistent-organic-pollutants-pops-and-prostate-cancer-risk-a-case-cohort-study
#10
Jung-Eun Lim, Chungmo Nam, Jiyeon Yang, Koon Ho Rha, Kyung-Min Lim, Sun Ha Jee
It is still unclear whether persistent organic pollutants (POPs) exposure increases the prostate cancer incidence risk. This prospective cohort study evaluated the associations between serum POPs concentrations and prostate cancer risk. Within a case-cohort study, we identified 110 people diagnosed with prostate cancer and randomly selected 256 sub-cohort participants without prostate cancer. Serum concentrations of 32 polychlorinated biphenyl (PCB) congeners and 19 organochlorine pesticides (OCPs) were measured...
April 10, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28404607/interpreting-incidentally-identified-variants-in-genes-associated-with-catecholaminergic-polymorphic-ventricular-tachycardia-in-a-large-cohort-of-clinical-whole-exome-genetic-test-referrals
#11
Andrew P Landstrom, Andrew L Dailey-Schwartz, Jill A Rosenfeld, Yaping Yang, Margaret J McLean, Christina Y Miyake, Santiago O Valdes, Yuxin Fan, Hugh D Allen, Daniel J Penny, Jeffrey J Kim
BACKGROUND: The rapid expansion of genetic testing has led to increased utilization of clinical whole-exome sequencing (WES). Clinicians and genetic researchers are being faced with assessing risk of disease vulnerability from incidentally identified genetic variants which is typified by variants found in genes associated with sudden death-predisposing catecholaminergic polymorphic ventricular tachycardia (CPVT). We sought to determine whether incidentally identified variants in genes associated with CPVT from WES clinical testing represent disease-associated biomarkers...
April 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28393590/feasibility-of-extended-dosing-intervals-of-denosumab
#12
Jacob K Kettle, Puja B Patel
Purpose Denosumab is a crucial supportive care agent for patients with advanced cancers affecting the bone. Despite the importance of treatment, logistical and financial obstacles hinder the ability to maintain long-term adherence. This analysis was designed to provide preliminary data regarding the feasibility of extended denosumab dosing intervals. Methods This retrospective, case cohort study was conducted on patients receiving treatment with denosumab for malignancies with bone involvement. A total of 60 patients were identified for analysis and were divided into cohorts according to the average number of days between denosumab doses...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28393470/associations-of-coagulation-factors-ix-and-xi-levels-with-incident-coronary-heart-disease-and-ischemic-stroke-the-regards-study
#13
N C Olson, M Cushman, S E Judd, B M Kissela, M M Safford, G Howard, N A Zakai
BACKGROUND: Recent studies suggest the importance of coagulation factor IX (FIX) and FXI in cardiovascular disease (CVD) risk. OBJECTIVES: To determine whether basal levels of FIX or FXI antigen were associated with risk of incident coronary heart disease (CHD) or ischemic stroke. PATIENTS/METHODS: The REasons for Geographic And Racial Differences in Stroke (REGARDS) study recruited 30,239 participants across the contiguous U.S. between 2003-07...
April 10, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28391539/interactions-between-dietary-acrylamide-intake-and-genes-for-ovarian-cancer-risk
#14
Janneke G F Hogervorst, Piet A van den Brandt, Roger W L Godschalk, Frederik-Jan van Schooten, Leo J Schouten
Some epidemiological studies observed a positive association between dietary acrylamide intake and ovarian cancer risk but the causality needs to be substantiated. By analyzing gene-acrylamide interactions for ovarian cancer risk for the first time, we aimed to contribute to this. The prospective Netherlands Cohort Study on diet and cancer includes 62,573 women, aged 55-69 years. At baseline in 1986, a random subcohort of 2589 women was sampled from the total cohort for a case cohort analysis approach. Dietary acrylamide intake of subcohort members and ovarian cancer cases (n = 252, based on 20...
April 8, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28382514/intake-of-meat-and-fish-and-risk-of-head-neck-cancer-subtypes-in-the-netherlands-cohort-study
#15
Andy Perloy, Denise H E Maasland, Piet A van den Brandt, Bernd Kremer, Leo J Schouten
PURPOSE: To date, the role of meat and fish intake in head-neck cancer (HNC) etiology is not well understood and prospective evidence is limited. This prompted us to study the association between meat, fish, and HNC subtypes, i.e., oral cavity cancer (OCC), oro- and hypopharyngeal cancer (OHPC), and laryngeal cancer (LC), within the Netherlands Cohort Study (NLCS). METHODS: In 1986, 120,852 participants (aged 55-69 years) completed a baseline 150-item food frequency questionnaire (FFQ), from which daily meat and fish intake were calculated...
June 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28376216/urinary-cadmium-and-breast-cancer-a-prospective-danish-cohort-study
#16
Kirsten T Eriksen, Jane A McElroy, James M Harrington, Keith E Levine, Camilla Pedersen, Mette Sørensen, Anne Tjønneland, Jaymie R Meliker, Ole Raaschou-Nielsen
Background: Cadmium is a human lung carcinogen, and recent evidence suggests it may play a role in hormone-related cancers because of its estrogenic activity. Case-control studies consistently show higher cadmium concentrations in urine from women diagnosed with breast cancer compared with control women. Our aim was to investigate the association between urinary cadmium and breast cancer in a prospective design. Methods: We conducted a case-cohort study using the population-based Danish Diet Cancer and Health Cohort...
February 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28374930/physical-activity-and-the-risk-of-preterm-birth-a-systematic-review-and-meta-analysis-of-epidemiological-studies
#17
Dagfinn Aune, Sabrina Schlesinger, Tore Henriksen, Ola Didrik Saugstad, Serena Tonstad
BACKGROUND: Physical activity has been inconsistently associated with risk of preterm birth, and the strength of the association and the shape of the dose-response relationship needs clarification. OBJECTIVES: To conduct a systematic review and dose-response meta-analysis to clarify the association between physical activity and risk of preterm birth. SEARCH STRATEGY: PubMed, Embase and Ovid databases were searched for relevant studies up to February 9(th) 2017...
April 4, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28371433/urinary-markers-of-fibrosis-and-risk-of-cardiovascular-events-and-death-in-kidney-transplant-recipients-the-favorit-trial
#18
M Park, R Katz, M G Shlipak, D Weiner, R Tracy, V Jotwani, J Hughes-Austin, F Gabbai, C Y Hsu, M Pfeffer, N Bansal, A Bostom, O Gutierrez, M Sarnak, A Levey, J H Ix
Cardiovascular risk remains high in kidney transplant recipients (KTRs) despite improved kidney function after transplant. Urinary markers of kidney fibrosis and injury may help to reveal mechanisms of this risk. In a case-cohort study among stable KTRs who participated in the FAVORIT trial, we measured four urinary proteins known to correlate with kidney tubulointerstitial fibrosis on biopsy (urine alpha 1 microglobulin [α1m], monocyte chemoattractant protein-1 [MCP-1], procollagen type I [PINP] and type III [PIIINP] N-terminal amino peptide) and evaluated associations with cardiovascular disease (CVD) events (n = 300) and death (n = 371)...
March 29, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28365588/associations-of-anthropometry-and-lifestyle-factors-with-hdl-subspecies-according-to-apolipoprotein-c-iii
#19
Manja Koch, Jeremy D Furtado, Gordon Z Jiang, Brianna E Gray, Tianxi Cai, Frank Sacks, Anne Tjønneland, Kim Overvad, Majken K Jensen
The presence of apolipoprotein C-III (apoC-III) on high-density lipoproteins (HDL) impairs HDL's inverse association with coronary heart disease. Little is known about modifiable factors explaining variation in HDL subspecies defined according to apoC-III. Aim was to investigate cross-sectional associations of anthropometry and lifestyle with HDL subspecies in 3631 participants from the Diet Cancer and Health study originally selected for a case-cohort study (36% women; age 50-65 y) who were all free of CHD...
April 1, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28365572/cost-effectiveness-analysis-for-genotyping-before-allopurinol-treatment-to-prevent-severe-cutaneous-adverse-drug-reactions
#20
Ching-Hua Ke, Wen-Hung Chung, Yen-Hsia Wen, Yaw-Bin Huang, Hung-Yi Chuang, You-Lin Tain, Yu-Ching Lily Wang, Cheng-Chih Wu, Chien-Ning Hsu
OBJECTIVE: Patients with an HLA-B*58:01 allele have an increased risk of developing severe cutaneous adverse drug reactions (SCAR) when treated with allopurinol. Although one-off pharmacogenetic testing may prevent life-threatening adverse drug reactions, testing prior to allopurinol initiation incurs additional costs. The study objective was to evaluate the cost-effectiveness of HLA-B*58:01 screening compared with using other available urate-lowering agents (ULA). METHODS: A decision-analytical model was used to compare direct medical costs and effectiveness [including lifetime saved, quality-adjusted life-yrs (QALY) gained] in treating new patients with the following options: (1) genetic screening followed by allopurinol prescribing for noncarriers of HLAB* 58:01, (2) prescribing benzbromarone without screening, (3) prescribing febuxostat without screening, and (4) prescribing allopurinol without screening...
April 1, 2017: Journal of Rheumatology
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