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https://www.readbyqxmd.com/read/28330765/hsp90-and-pcreb-alterations-are-linked-to-mancozeb-dependent-behavioral-and-neurodegenerative-effects-in-a-marine-teleost
#1
Merylin Zizza, Mariana Di Lorenzo, Vincenza Laforgia, Emilia Furia, Giovanni Sindona, Marcello Canonaco, Rosa Maria Facciolo
The pesticide mancozeb (mz) is recognized as a potent inducer of oxidative stress due to its ability to catalyze the production of reactive oxygen species plus inhibiting mitochondrial respiration thus becoming an environmental risk for neurodegenerative diseases. Despite numerous toxicological studies on mz have been directed to mammals, attention on marine fish is still lacking. Thus, it was our intention to evaluate neurobehavioral activities of ornate wrasses (Thalassoma pavo) exposed to 0.2mg/l of mz after a preliminary screening test (0...
March 19, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28318326/optimal-use-of-polyethylene-glycol-for-preparation-of-small-bowel-video-capsule-endoscopy-a-network-meta-analysis
#2
Shan Wu, Yun-Jie Gao, Zhi-Zheng Ge
OBJECTIVE: Standardized strategy of bowel preparation before video capsule endoscopy (VCE) remains controversial. We aimed to assess the ideal dose of PEG based on small bowel visualization quality (SBVQ), diagnostic yield (DY) and complete rate (CR) of VCE using a network meta-analysis (NMA) of randomized controlled trials (RCTs). METHODS: This NMA included RCTs comparing any of the following bowel preparation interventions for VCE: fasting overnight ('Fast'), 1 liter PEG ('PEG 1L'), 2-liter PEG ('PEG 2L'), or 4-liter PEG ('PEG 4L')...
March 20, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28286191/increased-intestinal-permeability-in-relatives-of-patients-with-crohn-s-disease-is-not-associated-with-small-bowel-ulcerations
#3
Christopher W Teshima, Karen J Goodman, Mohamed El-Kalla, Samina Turk, Wael El-Matary, Rosica Valcheva, Ronda Danchak, Marilyn Gordon, Peter Ho, Amanda Mullins, Daniel Wong, Dina Kao, Jonathan Meddings, Hien Huynh, Levinus A Dieleman
BACKGROUND & AIMS: Many first-degree relatives of patients with Crohn's disease (CD) have increased intestinal permeability. Video capsule endoscopy (VCE) is the most sensitive imaging test to identify small bowel mucosal lesions that indicate subclinical CD. We aimed to estimate the association of increased intestinal permeability with small bowel ulcerations detectable by VCE in healthy first-degree relatives of patients with CD. METHODS: We conducted a cross-sectional study of 223 healthy, asymptomatic first-degree relatives of patients with CD (parents, siblings, and children; 9-45 years old) enrolled at the University of Alberta between 2009 and 2012...
March 7, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28216967/assessment-of-multi-modality-evaluations-of-obscure-gastrointestinal-bleeding
#4
Ryan Law, Jithinraj E Varayil, Louis M WongKeeSong, Jeff Fidler, Joel G Fletcher, John Barlow, Jeffrey Alexander, Elizabeth Rajan, Stephanie Hansel, Brenda Becker, Joseph J Larson, Felicity T Enders, David H Bruining, Nayantara Coelho-Prabhu
AIM: To determine the frequency of bleeding source detection in patients with obscure gastrointestinal bleeding (OGIB) who underwent double balloon enteroscopy (DBE) after pre-procedure imaging [multiphase computed tomography enterography (MPCTE), video capsule endoscopy (VCE), or both] and assess the impact of imaging on DBE diagnostic yield. METHODS: Retrospective cohort study using a prospectively maintained database of all adult patients presenting with OGIB who underwent DBE from September 1(st), 2002 to June 30(th), 2013 at a single tertiary center...
January 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28193167/helicobacter-pylori-prevalence-and-clinical-significance-in-patients-with-quiescent-crohn-s-disease
#5
Adi Lahat, Uri Kopylov, Sandra Neuman, Nina Levhar, Doron Yablecovitch, Benjamin Avidan, Batia Weiss, Shomron Ben-Horin, Rami Eliakim
BACKGROUND: Helicobacter pylori (HP) infection is present in about 50% of the global population, and is associated with chronic gastritis, peptic disease and gastric malignancies. HP prevalence in Crohn's disease (CD) patients was shown to be low compared to the general population, and its influence on disease activity is yet to be determined. Our aims were to determine the prevalence of HP in a selected group of CD patients with quiescent disease, and to assess the influence of its eradication on disease activity and endoscopic and laboratory activity measures...
February 13, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28183152/genetic-correlations-between-male-reproductive-traits-and-growth-traits-in-growth-performance-tested-duroc-landrace-and-yorkshire-breed-boars
#6
Hsiu-Luan Chang, Yung-Yu Lai, Ming-Che Wu, Osamu Sasaki
Male-related traits at 180-225 days of age for 6464 grow-finish performance tested boars were measured from 2000 to 2016. Heritability estimates and genetic correlations among average daily gain, feed efficiency, back fat thickness, teat counts, mounting libido, leg locomotion, penile length, sperm motility, sperm concentration and total sperm counts were estimated by VCE software using a multiple traits animal model in each breed. Growth-tested boars had heritability estimates of male reproductive traits in 0...
February 9, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28103205/is-the-use-of-agile-patency-capsule-prior-to-videocapsule-endoscopy-useful-in-all-patients-with-spondyloarthritis
#7
Andrada Gheorghe, Denise Carmen Mihaela Zahiu, Theodor Alexandru Voiosu, Bogdan Radu Mateescu, Mihail Radu Voiosu, Mihai Rimbaş
BACKGROUND AND AIMS: As already known, spondyloarthritis patients present a striking resemblance in intestinal inflammation with early Crohn's disease. Moreover, the frequent use of nonsteroidal anti-inflammatory drugs is an important part of their treatment. Both conditions could lead to intestinal stenoses. Therefore we proposed to investigate the usefulness of the patency capsule test in patients with spondyloarthritis. MATERIAL AND METHODS: 64 consecutive patients (33 males; mean age 38 ± 11 years) that fulfilled the AMOR criteria for seronegative spondyloarthropathy (59...
January 18, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28076941/double-balloon-endoscopy-in-overt-and-occult-small-bowel-bleeding-results-complications-and-correlation-with-prior-videocapsule-endoscopy-in-a-tertiary-referral-center
#8
Carlijn Hermans, Arnold Stronkhorst, Annemarie Tjhie-Wensing, Jan Kamphuis, Bas van Balkom, Rob Dahlmans, Lennard Gilissen
BACKGROUND/AIMS: Videocapsule endoscopy (VCE) and double-balloon endoscopy (DBE) allow deep exploration in patients with suspected small bowel pathology. VCE is often performed as an initial small bowel examination to explore whether an intervention by DBE is indicated and to determine insertion route. The study aim was to evaluate the correlation between DBE and VCE in patients with obscure or overt bleeding or anemia, as well as intervention frequency, and complications. METHODS: Retrospective observational study...
January 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28069475/retention-associated-with-video-capsule-endoscopy-systematic-review-and-meta-analysis
#9
REVIEW
Mona Rezapour, Chidi Amadi, Lauren Gerson
BACKGROUND: Video capsule endoscopy (VCE) has become a major diagnostic tool for small-bowel evaluation. However, retention of the video capsule endoscope remains a major concern. METHODS: We performed a systematic review of VCE retention rates using Pubmed and SCOPUS (1995-2015). We included studies that enrolled at least 10 subjects, included VCE retention rates, and separated retention rates by indication. We used Comprehensive Meta-Analysis (Version 3.0) to calculate pooled prevalence rates with 95% confidence intervals and assessed heterogeneity using Cochran's Q statistic...
January 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28018097/contraindications-for-video-capsule-endoscopy
#10
REVIEW
Dirk Bandorski, Niehls Kurniawan, Peter Baltes, Reinhard Hoeltgen, Matthias Hecker, Dominik Stunder, Martin Keuchel
Video capsule endoscopy (VCE) has been applied in the last 15 years in an increasing field of applications. Although many contraindications have been put into perspective, some precautions still have to be considered. Known stenosis of the gastrointestinal tract is a clear contraindication for VCE unless surgery is already scheduled or at least has been considered as an optional treatment modality. In patients with a higher incidence of stenosis, as in an established diagnosis of Crohn's disease, clinical signs of obstruction, prior radiation or surgical small bowel resection, a preceding test with the self-dissolving patency capsule can override this contraindication...
December 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27990484/initial-experience-of-video-capsule-endoscopy-after-intestinal-transplantation
#11
Jonas Varkey, Mihai Oltean, Andreas Bernd Pischel, Magnus Simrén, Gustaf Herlenius
BACKGROUND: Intestinal transplantation is a procedure which inflicts immunological and infectious complications that affect the transplanted graft, posing both diagnostic and therapeutic challenges. Video capsule endoscopy (VCE) offers easy access to the entire small intestine and presents itself as an interesting option. However, at present, no studies evaluating the usefulness of video capsule endoscopies in this setting have been published. Our aim was to evaluate the usefulness of VCE in detecting complications that arise after intestinal transplantation...
December 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27908514/video-capsule-endoscopy-technology-reading-and-troubleshooting
#12
REVIEW
Jodie A Barkin, Jamie S Barkin
Video capsule endoscopy (VCE) has completed the endoscopic visualization of the entire luminal gastrointestinal tract. VCE can be performed in inpatients and outpatients, requires appropriate bowel preparation before the study, and can be administered via oral swallowing or endoscopic device placement into the small bowel based on outlined patient-dependent factors. Current commercially available VCE systems were reviewed and compared for individual features and attributes. This article focuses on preparation for VCE, currently available VCE technology, how to read a VCE study, and risks and contraindications to VCE...
January 2017: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/27775952/a-13-year-time-trend-analysis-of-3724-small-bowel-video-capsule-endoscopies-and-a-forecast-model-during-the-financial-crisis-in-greece
#13
Konstantinos Triantafyllou, Paraskevas Gkolfakis, Nikos Viazis, Panagiotis Tsibouris, Athanasios Tsigaridas, Periklis Apostolopoulos, John Anastasiou, Eleni Hounda, Ioannis Skianis, Konstantina Katopodi, Xhoela Ndini, George Alexandrakis, Demetrios G Karamanolis
INTRODUCTION: Since its introduction, small bowel video capsule endoscopy (VCE) use has evolved considerably. AIM: Evaluation of the temporal changes of small bowel VCE utilization in three tertiary centers in Greece in Era 1 (2002-2009) and Era 2 (2010-2014) and the development a forecast model for future VCE use during 2015-2017. MATERIALS AND METHODS: Data from all small bowel VCE examinations were retrieved and analyzed in terms of the annual number of the performed examinations, their indications and the significance of their findings...
February 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27652171/double-balloon-endoscopy-was-effective-in-diagnosing-small-intestinal-duplication-a-case-report
#14
Yuji Nadatani, Toshio Watanabe, Takashi Sugawa, Shinpei Eguchi, Sunao Shimada, Koji Otani, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Kazunari Tominaga, Yasuhiro Fujiwara, Tetsuo Arakawa
INTRODUCTION: Ileal duplications are encountered infrequently in adults, because symptoms including abdominal pain, intussusception, hemorrhage, and perforation usually present in early childhood. In this report, we present an adult case of ileal duplication that was revealed by double-balloon endoscopy (DBE). CASE DESCRIPTION: A 73-year-old Japanese man presented with anemia and melena. Anal DBE detected the narrow opening of an extra lumen in the ileum about 100 cm proximal to the ileocecal valve...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27638037/early-life-low-intensity-stress-experience-modifies-acute-stress-effects-on-juvenile-brain-cell-proliferation-of-european-sea-bass-d-labrax
#15
S Fokos, M Pavlidis, T Yiotis, A Tsalafouta, N Papandroulakis, C R Dermon
Early life adversity may be critical for the brain structural plasticity that in turn would influence juvenile behaviour. To address this, we questioned whether early life environment has an impact on stress responses latter in life, using European sea bass, Dicentrarchus labrax, as a model organism. Unpredictable chronic low intensity stress (UCLIS), using a variety of moderate intensity stressors, was applied during two early ontogenetic stages, flexion or formation all fins. At juvenile stage, fish were exposed to acute stress and plasma cortisol, brain mRNA expression of corticosteroid receptors' genes (gr1, gr2, mr) and brain cell proliferation (using BrdU immunohistochemistry) were determined in experimental and matched controls...
September 13, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27582877/magnetic-resonance-enterography-versus-capsule-endoscopy-activity-indices-for-quantification-of-small-bowel-inflammation-in-crohn-s-disease
#16
Uri Kopylov, Eyal Klang, Doron Yablecovitch, Adi Lahat, Benjamin Avidan, Sandra Neuman, Nina Levhar, Tomer Greener, Noa Rozendorn, Arkadi Beytelman, Henit Yanai, Iris Dotan, Yehuda Chowers, Batya Weiss, Shomron Ben-Horin, Marianne M Amitai, Rami Eliakim
BACKGROUND: Video capsule endoscopy (VCE) and magnetic resonance enterography (MRE) are the prime modalities for the evaluation of small bowel (SB) Crohn's disease (CD). Mucosal inflammation on VCE is quantified using the Lewis score (LS). Diffusion-weighted (DW) magnetic resonance imaging (MRI) allows for accurate assessment of SB inflammation without administration of intravenous contrast material. The Magnetic Resonance Index of Activity (MaRiA) and the Clermont index are quantitative activity indices validated for contrast-enhanced MRE and DW-MRE, respectively...
September 2016: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/27548727/a-prospective-blinded-comparison-of-video-capsule-endoscopy-versus-computed-tomography-enterography-in-potential-small-bowel-bleeding-clinical-utility-of-computed-tomography-enterography
#17
Julajak Limsrivilai, Sitthipong Srisajjakul, Supot Pongprasobchai, Somchai Leelakusolvong, Tawesak Tanwandee
GOALS: To compare the efficacy of video capsule endoscopy (VCE) with computed tomography enterography (CTE) in potential small bowel (SB) bleeding, and to identify factors predictive of a high diagnostic yield for CTE. BACKGROUND: In potential SB bleeding, CTE potentially detects some lesions missed by VCE, but few data have determined its clinical utility. STUDY: Consecutive patients with potential SB bleeding were prospectively enrolled...
August 19, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27542424/the-approach-to-occult-gastrointestinal-bleed
#18
REVIEW
Edgar R Naut
Occult gastrointestinal bleeding is not visible and may present with a positive fecal occult blood test or iron deficiency anemia. Obscure bleeding can be overt or occult, with no source identified despite an appropriate diagnostic workup. A stepwise approach to this evaluation after negative upper and lower endoscopy has been shown to be cost effective. This includes repeat endoscopies if warranted, followed by video capsule endoscopy (VCE) if no obstruction is present. If the VCE is positive then specific endoscopic intervention may be possible...
September 2016: Medical Clinics of North America
https://www.readbyqxmd.com/read/27540577/evaluation-of-performance-of-the-omni-mode-for-detecting-video-capsule-endoscopy-images-a-multicenter-randomized-controlled-trial
#19
Naoki Hosoe, Kenji Watanabe, Takako Miyazaki, Masaaki Shimatani, Takahiro Wakamatsu, Kazuichi Okazaki, Motohiro Esaki, Takayuki Matsumoto, Takayuki Abe, Takanori Kanai, Kazuo Ohtsuka, Mamoru Watanabe, Keiichi Ikeda, Hisao Tajiri, Naoki Ohmiya, Masanao Nakamura, Hidemi Goto, Tomoyuki Tsujikawa, Haruhiko Ogata
BACKGROUND AND STUDY AIMS: Olympus recently developed a new algorithm called Omni mode that discards redundant video capsule endoscopy (VCE) images. The current study aimed to demonstrate the non-inferiority of the Omni mode in terms of true positives (TPs) and the superiority of the Omni mode with regard to reading time against a control (ordinary ES-10 system). PATIENTS AND METHODS: This multicenter prospective study included 40 patients with various small bowel diseases...
August 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27515212/novel-capsules-for-potential-theranostics-of-obscure-gastrointestinal-bleedings
#20
Bayram Çolak, Hüseyin Şakalak, Halit Çavuşoğlu, Mustafa Selman Yavuz
Obscure gastrointestinal (GI) bleeding is identified as persistent or repeated bleeding from the gastrointestinal tract which could not be defined by conventional gastrointestinal endoscopy and radiological examinations. These GI bleedings are assessed through invasive diagnostic and treatment methods including enteroscopy, angiography and endoscopy. In addition, video capsule endoscopy (VCE) is a non-invasive method used to determine the location of the bleeding, however, this does not provide any treatment...
September 2016: Medical Hypotheses
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