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https://www.readbyqxmd.com/read/28901467/aberrantly-expressed-transcription-factors-c-ebp-and-sox4-have-positive-effects-in-the-development-of-chronic-myeloid-leukemia
#1
Fei Dong, Guili Zhang, Xia Zhang, Xuena Liu, Na Wang, Chengming Sun
The aim of the present study was to examine the expression and significance of CCAAT/enhancer binding protein α (C/EBPα) and SRY‑related high mobility group box containing transcription factor 4 (SOX4) in chronic myeloid leukemia (CML). Bone marrow samples were collected from patients with CML, and peripheral blood mononuclear cells were collected from healthy controls. Protein and mRNA were extracted from the collected samples, and analyzed using western blotting and reverse transcription‑quantitative polymerase chain reaction analyses, respectively...
September 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28892663/hepatic-transcriptome-analysis-of-juvenile-gift-tilapia-oreochromis-niloticus-fed-diets-supplemented-with-different-concentrations-of-resveratrol
#2
Yao Zheng, Wei Wu, Gengdong Hu, Zhixiang Zhao, Shunlong Meng, Limin Fan, Chao Song, Liping Qiu, Jiazhang Chen
The GIFT (Genetically Improved Farmed Tilapia) tilapia, Oreochromis niloticus, is cultured widely for the production of freshwater fish in China. Streptococcosis, which is related to pathogenic infections, occurs frequently in juvenile and adult female GIFT individuals. Resveratrol (RES) has been used in feed to control these infections in freshwater tilapia. To address the effects of RES on tilapia, we used high-throughput RNA sequencing technology (RNA-Seq, HiSeq. 2500) to explore the global transcriptomic response and specific involvement of hepatic mRNA of juvenile O...
September 8, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28861152/microrna-138-attenuates-epithelial-to-mesenchymal-transition-by-targeting-sox4-in-clear-cell-renal-cell-carcinoma
#3
Feng Liu, Linfeng Wu, Anping Wang, Yajun Xu, Xiaodong Luo, Xing Liu, Yi Hua, Deying Zhang, Shengde Wu, Tao Lin, Dawei He, Guanghui Wei, Shanwen Chen
MicroRNAs (miRNAs) are small, non-coding RNAs which can serve as oncogenes or tumor suppressor genes in human cancers. Herein, the transcriptomic differences of miRNAs in ccRCC were globally assessed using publicly available microarray dataset (GSE71302) from Gene Expression Omnibus (GEO) and we identified miR-138 as a potential onco-suppressive miRNA. We further found that the expression of miR-138 was dramatically decreased in ccRCC cell lines and clinical ccRCC tissue samples, and the low miR-138 expression was closely correlated with tumor progression and prognosis in ccRCC patients...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28852381/soxc-transcription-factors-in-retinal-development-and-regeneration
#4
REVIEW
Kun-Che Chang, Jonathan Hertz
Glaucoma and other optic neuropathies result in optic nerve degeneration and the loss of retinal ganglion cells (RGCs) through complex signaling pathways. Although the mechanisms that regulate RGC development remain unclear, uncovering novel developmental pathways may support new strategies to regenerate the optic nerve or replace RGCs. Here we review recent studies that provide strong evidence that the Sry-related high-mobility-group C (SoxC) subfamily of transcription factors (TFs) are necessary and sufficient for axon guidance and RGC fate specification...
July 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28841206/overexpression-of-sox4-correlates-with-poor-prognosis-of-acute-myeloid-leukemia-and-is-leukemogenic-in-zebrafish
#5
J-W Lu, M-S Hsieh, H-A Hou, C-Y Chen, H-F Tien, L-I Lin
The SOX4 transcription factor is a key regulator of embryonic development, cell-fate decision, cellular differentiation and oncogenesis. Abnormal expression of SOX4 is related to malignant tumor transformation and cancer metastasis. However, no reports are available regarding the clinical significance of SOX4 in acute myeloid leukemia (AML) and the role of SOX4 in leukemogenesis. In the current study, we found that AML patients with low bone marrow (BM) SOX4 expression had higher remission rates and longer overall survival than those with high SOX4 expression, regardless of age, white blood cell count at diagnosis, karyotype profile and NPM1/FLT3-ITD status...
August 25, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28837676/alk-signaling-cascade-confers-multiple-advantages-to-glioblastoma-cells-through-neovascularization-and-cell-proliferation
#6
Risako Chiba, Masashi Akiya, Miki Hashimura, Yasuko Oguri, Madoka Inukai, Atsuko Hara, Makoto Saegusa
Anaplastic lymphoma kinase (ALK), which is a receptor tyrosine kinase, is essentially and transiently expressed in the developing nervous system. Here we examined the functional role of the ALK gene in glioblastomas (GBMs). In clinical samples of GBMs, high ALK expression without gene rearrangements or mutations was frequently observed in perivascular lesions, in contrast to the relatively low expression in the perinecrotic areas, which was positively correlated with N-myc and phosphorylated (p) Stat3 scores and Ki-67 labeling indices...
2017: PloS One
https://www.readbyqxmd.com/read/28810927/stat3-mediated-upregulation-of-lncrna-hoxd-as1-as-a-cerna-facilitates-liver-cancer-metastasis-by-regulating-sox4
#7
Hui Wang, Xisong Huo, Xin-Rong Yang, Jia He, Lijun Cheng, Na Wang, Xuan Deng, Haojie Jin, Ning Wang, Cun Wang, Fangyu Zhao, Jingyuan Fang, Ming Yao, Jia Fan, Wenxin Qin
BACKGROUND: Several of the thousands of human long noncoding RNAs (lncRNAs) have been functionally characterized, yet their potential involvement in hepatocellular carcinoma (HCC) remains poorly understood. METHODS: LncRNA-HOXD-AS1 was identified by microarray and validated by real-time PCR. The clinicopathological significance of HOXD-AS1 was analyzed by Kaplan-Meier method. Chromatin immunoprecipitation was conducted to examine the mechanism of HOXD-AS1 upregulation...
August 14, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28791372/microrna-212-functions-as-a-tumor-suppressor-in-human-non-small-cell-lung-cancer-by-targeting-sox4
#8
Tingting Tang, Liting Huan, Shujuan Zhang, Hui Zhou, Lei Gu, Xiaohui Chen, Liang Zhang
Increasing evidence has revealed that aberrant expression of miRNAs contributes to non-small cell lung cancer (NSCLC) development and progression. However, the roles and mechanisms of various miRNAs in NSCLC remain to be determined. In the present study, we confirmed that reduced miR-212 expression was present in NSCLC tissues and cell lines. Our clinical analysis revealed that the reduced miR-212 expression was significantly correlated with poor prognostic features including positive lymph node metastasis and advanced tumor-node-metastasis (TNM) stage...
August 7, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28780934/sox4-joining-the-master-regulators-of-epithelial-to-mesenchymal-transition
#9
REVIEW
Ana Rita Lourenço, Paul J Coffer
The epithelial-to-mesenchymal transition (EMT) is an important developmental program exploited by cancer cells to gain mesenchymal features. Transcription factors globally regulating processes during EMT are often referred as 'master regulators' of EMT, and include members of the Snail and ZEB transcription factor families. The SRY-related HMG box (SOX) 4 transcription factor can promote tumorigenesis by endowing cells with migratory and invasive properties, stemness, and resistance to apoptosis, thereby regulating key aspects of the EMT program...
August 2017: Trends in Cancer
https://www.readbyqxmd.com/read/28765961/upregulation-of-microrna-25-3p-inhibits-proliferation-migration-and-invasion-of-osteosarcoma-cells-in%C3%A2-vitro-by-directly-targeting-sox4
#10
Xiaolin Wu, Hongzhong Zhou, Bin Yue, Maohua Li, Fengxia Liu, Chensheng Qiu, Bohua Chen, Xuexiao Ma
Osteosarcoma (OS) is among the most common primary tumors of bone tissue, and occurs primarily in children and young adults. Despite the development of novel therapeutic approaches, the prognosis of OS remains poor. MicroRNAs (miRNAs) are involved in the development and progression of various types of human cancer and may have potential as novel therapeutic targets for cancer treatment. The present study aimed to investigate the expression and biological functions of miRNA‑25‑3p in OS, and explore the molecular mechanisms underlying its actions...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28760661/sox4-promotes-proliferative-signals-by-regulating-glycolysis-through-akt-activation-in-melanoma-cells
#11
Wei Dai, Xinyuan Xu, Shuli Li, Jingjing Ma, Qiong Shi, Sen Guo, Lin Liu, Weinan Guo, Peng Xu, Yuanmin He, Guannan Zhu, Liwen Wang, Rui Ge, Yu Liu, Zhe Jian, Gang Wang, Lan Shen, Tianwen Gao, Chunying Li
The sex-determining region Y-related high-mobility-group box transcription factor 4 (SOX4) plays a fundamental role during embryogenesis and controls cell fate and differentiation. Recently, increased SOX4 expression has been reported in various cancer types, contributing to the progression and survival of cancer cells. However, the distinct functions and downstream targets of SOX4 remain to be fully elucidated. In this study, we initially found elevated SOX4 expression in melanoma. SOX4 regulates apoptosis and cell cycle arrest, affects glucose consumption and lactate production, and consequently, promotes melanoma cell proliferation...
July 28, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28724437/the-lncrna-casc15-regulates-sox4-expression-in-runx1-rearranged-acute-leukemia
#12
Thilini R Fernando, Jorge R Contreras, Matteo Zampini, Norma I Rodriguez-Malave, Michael O Alberti, Jaime Anguiano, Tiffany M Tran, Jayanth K Palanichamy, Jasmine Gajeton, Nolan M Ung, Cody J Aros, Ella V Waters, David Casero, Giuseppe Basso, Martina Pigazzi, Dinesh S Rao
BACKGROUND: Long non-coding RNAs (lncRNAs) play a variety of cellular roles, including regulation of transcription and translation, leading to alterations in gene expression. Some lncRNAs modulate the expression of chromosomally adjacent genes. Here, we assess the roles of the lncRNA CASC15 in regulation of a chromosomally nearby gene, SOX4, and its function in RUNX1/AML translocated leukemia. RESULTS: CASC15 is a conserved lncRNA that was upregulated in pediatric B-acute lymphoblastic leukemia (B-ALL) with t (12; 21) as well as pediatric acute myeloid leukemia (AML) with t (8; 21), both of which are associated with relatively better prognosis...
July 19, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28705117/microrna-25-suppresses-proliferation-migration-and-invasion-of-osteosarcoma-by-targeting-sox4
#13
Bingpeng Chen, Jingjing Liu, Ji Qu, Yang Song, Yuxiang Li, Su Pan
Altered expression of the miR-25 has been implicated in many human malignant progression as oncogene or tumor suppressor. However, the precise role of miR-25 in osteosarcoma progression remains largely unclear. This study aimed to investigate the role and underlying mechanism of miR-25 in osteosarcoma. In this study, we demonstrated that miR-25 was significantly downregulated in osteosarcoma cell lines and tissues and that lower miR-25 was associated with advanced tumor-node-metastasis stage and lymph node metastasis...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28697535/cancer-stem-cells-and-epithelial-mesenchymal-transition-in-urothelial-carcinoma-possible-pathways-and-potential-therapeutic-approaches
#14
REVIEW
Dong Fang, Hiroshi Kitamura
There is growing evidence of the presence of cancer stem cells in urothelial carcinoma. Cancer stem cells have the ability to self-renew and to differentiate into all cell types of the original heterogeneous tumor. A panel of diverse cancer stem cell markers might be suitable for simulation studies of urothelial cancer stem cells and for the development of optimized treatment protocols. The present review focuses on the advances in recognizing the markers of urothelial cancer stem cells and possible therapeutic targets...
July 11, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28656304/mir-138-inhibits-gastric-cancer-growth-by-suppressing-sox4
#15
Lei Pang, Bai Li, Baisong Zheng, Liang Niu, Liang Ge
MicroRNA-138 (miR-138) has been reported to be downregulated and function as a tumor suppressor in several cancers. However, the role and molecular mechanisms of miR-138 in the progression of gastric cancer (GC) remain to be clarified. The aim of the present study was to determine the role of miR-138 in GC progression. In the present study we found that miR-138 expression was downregulated in GC tissues and cell lines. Statistical analysis demonstrated that low expression levels of miR-138 were associated with advanced tumor-node-metastasis (TNM) stage, and lymph node metastasis...
June 22, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28653608/microrna-138-inhibits-cell-growth-invasion-and-emt-of-non-small-cell-lung-cancer-via-sox4-p53-feedback-loop
#16
Dandan Li, Changjun He, Junfeng Wang, Yanbo Wang, Jianlong Bu, Xianglong Kong, Dawei Sun
Many studied have shown that down-regulated level of miR-138 is in a variety of cancers including non-small cell lung cancer (NSCLC). However, the precise mechanisms of miR-138 in NSCLC have not been well clarified. In this study, we investigated the biological functions and molecular mechanisms of miR-138 in NSCLC cell lines, discussing whether it could be a therapeutic biomarker of NSCLC in the future. In our study, we found that miR-138 is down-regulated in NSCLC tissues and cell lines. Moreover, the low level of miR-138 was associated with increased expression of SOX4 in NSCLC tissues and cell lines...
June 13, 2017: Oncology Research
https://www.readbyqxmd.com/read/28629960/molecular-cloning-and-mrna-expression-pattern-of-sox4-in-paramisgurnus-dabryanus
#17
Xiaohua Xia, Ruyan Wan, Weiran Huo, Linxia Zhang, Xiaopei Xia, Zhongjie Chang
Sox4 belonged to the SoxC subfamily of the Sox family, which play important roles in the development of the vertebrate gonad and nervous system. A Sox4 homologue was cloned from brain of Paramisgurnus dabryanus by using homologous cloning and rapid amplification of cDNA ends (RACE), designated as PdSox4. The full-length cDNA was 2163bp, containing the 759bp 5'-untranslated region, 267bp 3'-untranslated region and encoding a putative protein of 378 amino acids with a characteristic high mobility group box (HMG-box) DNA-binding domain of 79 amino acids with the specific motif (RPMNAFMVW)...
June 16, 2017: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/28627651/sox4-promotes-melanoma-cell-migration-and-invasion-though-the-activation-of-the-nf-%C3%AE%C2%BAb-signaling-pathway
#18
Qiong Cheng, Jinfeng Wu, Yaohua Zhang, Xiao Liu, Nan Xu, Fuguo Zuo, Jinhua Xu
SOX4 has been reported to be abnormally expressed in many types of cancer, including melanoma. However, its role in cell proliferation and metastasis remains controversial. In this study, SOX4 was downregulated or overexpressed in A375, A2058 and A875 melanoma cells by siRNA or lentivirus transfection, respectively. Cell metastasis was observed by Transwell assay. In an aim to elucidate the underlying mechanisms, we determined the expression of nuclear factor-κB (NF-κB) by real-time PCR assay and western blot analysis...
June 16, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28625800/arsenic-alters-transcriptional-responses-to-pseudomonas-aeruginosa-infection-and-decreases-antimicrobial-defense-of-human-airway-epithelial-cells
#19
Britton C Goodale, Erica J Rayack, Bruce A Stanton
Arsenic contamination of drinking water and food threatens the health of hundreds of millions of people worldwide by increasing the risk of numerous diseases. Arsenic exposure has been associated with infectious lung disease in epidemiological studies, but it is not yet understood how ingestion of low levels of arsenic increases susceptibility to bacterial infection. Accordingly, the goal of this study was to examine the effect of arsenic on gene expression in primary human bronchial epithelial (HBE) cells and to determine if arsenic altered epithelial cell responses to Pseudomonas aeruginosa, an opportunistic pathogen...
September 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28615725/transcriptome-analysis-reveals-similarities-between-human-blood-cd3-cd56-bright-cells-and-mouse-cd127-innate-lymphoid-cells
#20
David S J Allan, Ana Sofia Cerdeira, Anuisa Ranjan, Christina L Kirkham, Oscar A Aguilar, Miho Tanaka, Richard W Childs, Cynthia E Dunbar, Jack L Strominger, Hernan D Kopcow, James R Carlyle
For many years, human peripheral blood natural killer (NK) cells have been divided into functionally distinct CD3(-) CD56(bright) CD16(-) and CD3(-) CD56(dim) CD16(+) subsets. Recently, several groups of innate lymphoid cells (ILC), distinct from NK cells in development and function, have been defined in mouse. A signature of genes present in mouse ILC except NK cells, defined by Immunological Genome Project studies, is significantly over-represented in human CD56(bright) cells, by gene set enrichment analysis...
June 14, 2017: Scientific Reports
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