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https://www.readbyqxmd.com/read/29222418/heb-is-required-for-the-specification-of-fetal-il-17-producing-%C3%AE-%C3%AE-t-cells
#1
Tracy S H In, Ashton Trotman-Grant, Shawn Fahl, Edward L Y Chen, Payam Zarin, Amanda J Moore, David L Wiest, Juan Carlos Zúñiga-Pflücker, Michele K Anderson
IL-17-producing γδ T (γδT17) cells are critical components of the innate immune system. However, the gene networks that control their development are unclear. Here we show that HEB (HeLa E-box binding protein, encoded by Tcf12) is required for the generation of a newly defined subset of fetal-derived CD73- γδT17 cells. HEB is required in immature CD24+CD73- γδ T cells for the expression of Sox4, Sox13, and Rorc, and these genes are repressed by acute expression of the HEB antagonist Id3. HEB-deficiency also affects mature CD73+ γδ T cells, which are defective in RORγt expression and IL-17 production...
December 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29218242/long-noncoding-rna-lncbrm-facilitates-the-proliferation-migration-and-invasion-of-ovarian-cancer-cells-via-upregulation-of-sox4
#2
Jie Xi, Jing Feng, Saitian Zeng
Ovarian cancer (OC) is one of the most fatal gynecological cancer in women worldwide. Long noncoding RNA (lncRNA) lncBRM was found to be associated with the progression and prognosis of hepatocellular carcinoma (HCC). However, the expression level, clinical significance and functions in OC tumorigenesis and progression remain unclear. Our present research demonstrated that lncBRM expression was significantly increased in OC tissues. Upregulation of lncBRM expression was correlated with histological grade, FIGO stages, lymph node metastasis and poor prognosis of patients with OC...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29201237/microrna-338-3p-targets-sox4-and-inhibits-cell-proliferation-and-invasion-of-renal-cell-carcinoma
#3
Zhigang Tong, Xianfeng Meng, Jinsong Wang, Lixin Wang
MicroRNA (miR)-338-3p has been reported to be involved in tumor progression and development in various types of cancer. However, the biological function of miR-338-3p and its related molecular pathways involved in the progression of renal cell carcinoma (RCC) are unknown. The present study aimed to investigate the biological role and underlying mechanism of miR-338-3p in RCC cells. It was demonstrated that miR-338-3p expression level was significantly downregulated (P<0.05) in RCC tissues and cell lines...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29193895/inflammatory-cytokines-stabilize-soxc-transcription-factors-to-mediate-the-transformation-of-fibroblast-like-synoviocytes-in-arthritic-disease
#4
Pallavi Bhattaram, George Muschler, Viktor Wixler, Véronique Lefebvre
OBJECTIVES: Fibroblast-like synoviocytes (FLS) produce key synovial fluid and tissue components to ensure joint integrity under healthy conditions, whereas they become cancer-like and aggressively contribute to joint degeneration in inflammatory arthritis. Here we asked whether the SOXC transcription factors SOX4 and SOX11, whose functions are critical in joint development and many cancer types, contribute to FLS activities under normal and inflammatory conditions. METHODS: We inactivated the SOXC genes in FLS of adult mice and studied consequences on joint homeostasis and tumor necrosis factor-alpha (TNFα)-induced arthritis...
November 28, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29180230/glucocorticoids-genes-and-brain-function
#5
REVIEW
Grzegorz R Juszczak, Adrian M Stankiewicz
The identification of key genes in transcriptomic data constitutes a huge challenge. Our review of microarray reports revealed 88 genes whose transcription is consistently regulated by glucocorticoids (GCs), such as cortisol, corticosterone and dexamethasone, in the brain. Replicable transcriptomic data were combined with biochemical and physiological data to create an integrated view of the effects induced by GCs. The most frequently reported genes were Errfi1 and Ddit4. Their up-regulation was associated with the altered transcription of genes regulating growth factor and mTORC1 signaling (Gab1, Tsc22d3, Dusp1, Ndrg2, Ppp5c and Sesn1) and progression of the cell cycle (Ccnd1, Cdkn1a and Cables1)...
November 24, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29131257/long-noncoding-rna-casc2-inhibits-metastasis-and-epithelial-to-mesenchymal-transition-of-lung-adenocarcinoma-via-suppressing-sox4
#6
D Wang, Z-M Gao, L-G Han, F Xu, K Liu, Y Shen
OBJECTIVE: Recently, long non-coding RNAs (lncRNAs) have caught more attention for their role in tumor progression. Lung adenocarcinoma (LAC) is one of these ordinary malignant tumors. This study aims to identify whether lncRNA CASC2 (cancer susceptibility candidate 2) can regulate the metastasis of LAC, and find out its potential mechanism. PATIENTS AND METHODS: RT-qPCR was conducted to detect CASC2 expression level in 63 LAC tissues and 4 LAC cells. Besides, statistical methods were applied to analyze clinical data and prognosis in the 63 patients...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29079881/soxc-transcription-factors-multifunctional-regulators-of-neurodevelopment
#7
REVIEW
Atria Kavyanifar, Soeren Turan, D Chichung Lie
During development, generation of neurons is coordinated by the sequential activation of gene expression programs by stage- and subtype-specific transcription factor networks. The SoxC group transcription factors, Sox4 and Sox11, have recently emerged as critical components of this network. Initially identified as survival and differentiation factors for neural precursors, SoxC factors have now been linked to a broader array of developmental processes including neuronal subtype specification, migration, dendritogenesis and establishment of neuronal projections, and are now being employed in experimental strategies for neuronal replacement and axonal regeneration in the diseased central nervous system...
October 27, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29072699/cited2-affects-leukemic-cell-survival-by-interfering-with-p53-activation
#8
Katharina Mattes, Gerbrig Berger, Marjan Geugien, Edo Vellenga, Hein Schepers
CITED2 (CBP/p300-interacting-transactivator-with-an-ED-rich-tail 2) is a regulator of the acetyltransferase CBP/p300 and elevated CITED2 levels are shown in a number of acute myeloid leukemia (AML). To study the in vivo role of CITED2 in AML maintenance, AML cells were transduced with a lentiviral construct for RNAi-mediated knockdown of CITED2. Mice transplanted with CITED2-knockdown AML cells (n=4) had a significantly longer survival compared to mice transplanted with control AML cells (P<0.02). In vitro, the reduction of CITED2 resulted in increased p53-mediated apoptosis and CDKN1A expression, whereas BCL2 levels were reduced...
October 26, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29039454/sox4-arrests-lung-development-in-rats-with-hyperoxia%C3%A2-induced-bronchopulmonary-dysplasia-by-controlling-ezh2-expression
#9
Bingting Pan, Xindong Xue, Dan Zhang, Mengyun Li, Jianhua Fu
Bronchopulmonary dysplasia (BPD) is currently the most common severe complication in premature infants and is characterized by the arrest of alveolar and vascular growth. Alveolar type II cells play an important role in the pathological foundation of BPD. An association of BPD with epithelial‑to‑mesenchymal transition (EMT) in type II cells exposed to hyperoxia was previously identified. SOX4, a transcription factor that is indispensable to embryogenesis, including lung development, participates in regulating EMT and cell survival, affecting tumorigenesis...
October 3, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29038881/downregulated-sox4-expression-suppresses-cell-proliferation-migration-and-induces-apoptosis-in-osteosarcoma-in-vitro-and-in-vivo
#10
Dong Chen, Chuanzhen Hu, Gen Wen, Qingcheng Yang, Changqing Zhang, Huilin Yang
The SOX4 transcription factor is involved in various cellular processes, such as embryonic development and differentiation. Deregulated expression of Sox4 in several human cancers has been reported to date, but its biological functions in the progression of osteosarcoma remain unclear. In this study, we found that the expression levels of SOX4 protein were significantly higher in high-grade osteosarcoma tissues and metastatic osteosarcoma tissues. Its overexpression was associated with poor prognosis in osteosarcoma...
October 16, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29031500/transcription-and-signaling-regulators-in-developing-neuronal-subtypes-of-mouse-and-human-enteric-nervous-system
#11
Fatima Memic, Viktoria Knoflach, Khomgrit Morarach, Rebecca Sadler, Catia Laranjeira, Jens Hjerling-Leffler, Erik Sundström, Vassilis Pachnis, Ulrika Marklund
BACKGROUND AND AIMS: The enteric nervous system (ENS) regulates gastrointestinal function via different subtypes of neurons, organized into fine-tuned neural circuits. It is not clear how cell diversity is created within the embryonic ENS-information required for development of cell-based therapies and models of enteric neuropathies. We aimed to identify proteins that regulate ENS differentiation and network formation. METHODS: We generated and compared RNA expression profiles of the entire ENS, ENS progenitor cells, and non-ENS gut cells of mice, collected at embryonic days 11...
October 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29020498/lncrna-ccat1-mir-130a-3p-axis-increases-cisplatin-resistance-in-non-small-cell-lung-cancer-cell-line-by-targeting-sox4
#12
Baoli Hu, Haifeng Zhang, Zuopei Wang, Feng Zhang, Haitao Wei, Li Li
BACKGROUND: Colon cancer-associated transcript-1 (CCAT1) has been demonstrated to act as an oncogene and promote chemoresistance in several cancers. However, little is known about the underlying mechanism of CCAT1 in cisplatin (DDP) resistance of non-small-cell lung cancer (NSCLC) cells. METHODS: qRT-PCR was performed to detect the expression levels of CCAT, miR-130a-3p, or sex-determining region Y-box 4 (SOX4) mRNA. Luciferase reporter assay, RNA immunoprecipitation (RIP), and qRT-PCR analysis were carried out to explore the potential targets of CCAT1 or miR-130a-3p...
October 11, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28927144/mir-381-inhibits-migration-and-invasion-in-human-gastric-carcinoma-through-downregulatedting-sox4
#13
Mingming Zhang, Shishu Huang, Dan Long
Aberrant expression of microRNAs (miRs) serves essential roles in the generation and progression of various types of human cancer. In the present study, the expression and biological functions of miR-381 in human gastric carcinoma (GC) were focused upon. The results of reverse transcription-quantitative polymerase chain reaction analysis revealed that the expression of miR-381 was significantly downregulated in GC tissue samples. Furthermore, low expression of miR-381 was identified to be associated with lymphatic metastasis and advanced tumor-node-metastasis stage (III+IV)...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28901467/aberrantly-expressed-transcription-factors-c-ebp-and-sox4-have-positive-effects-in-the-development-of-chronic-myeloid-leukemia
#14
Fei Dong, Guili Zhang, Xia Zhang, Xuena Liu, Na Wang, Chengming Sun
The aim of the present study was to examine the expression and significance of CCAAT/enhancer binding protein α (C/EBPα) and SRY‑related high mobility group box containing transcription factor 4 (SOX4) in chronic myeloid leukemia (CML). Bone marrow samples were collected from patients with CML, and peripheral blood mononuclear cells were collected from healthy controls. Protein and mRNA were extracted from the collected samples, and analyzed using western blotting and reverse transcription‑quantitative polymerase chain reaction analyses, respectively...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28892663/hepatic-transcriptome-analysis-of-juvenile-gift-tilapia-oreochromis-niloticus-fed-diets-supplemented-with-different-concentrations-of-resveratrol
#15
Yao Zheng, Wei Wu, Gengdong Hu, Zhixiang Zhao, Shunlong Meng, Limin Fan, Chao Song, Liping Qiu, Jiazhang Chen
The GIFT (Genetically Improved Farmed Tilapia) tilapia, Oreochromis niloticus, is cultured widely for the production of freshwater fish in China. Streptococcosis, which is related to pathogenic infections, occurs frequently in juvenile and adult female GIFT individuals. Resveratrol (RES) has been used in feed to control these infections in freshwater tilapia. To address the effects of RES on tilapia, we used high-throughput RNA sequencing technology (RNA-Seq, HiSeq. 2500) to explore the global transcriptomic response and specific involvement of hepatic mRNA of juvenile O...
January 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28861152/microrna-138-attenuates-epithelial-to-mesenchymal-transition-by-targeting-sox4-in-clear-cell-renal-cell-carcinoma
#16
Feng Liu, Linfeng Wu, Anping Wang, Yajun Xu, Xiaodong Luo, Xing Liu, Yi Hua, Deying Zhang, Shengde Wu, Tao Lin, Dawei He, Guanghui Wei, Shanwen Chen
MicroRNAs (miRNAs) are small, non-coding RNAs which can serve as oncogenes or tumor suppressor genes in human cancers. Herein, the transcriptomic differences of miRNAs in ccRCC were globally assessed using publicly available microarray dataset (GSE71302) from Gene Expression Omnibus (GEO) and we identified miR-138 as a potential onco-suppressive miRNA. We further found that the expression of miR-138 was dramatically decreased in ccRCC cell lines and clinical ccRCC tissue samples, and the low miR-138 expression was closely correlated with tumor progression and prognosis in ccRCC patients...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28852381/soxc-transcription-factors-in-retinal-development-and-regeneration
#17
REVIEW
Kun-Che Chang, Jonathan Hertz
Glaucoma and other optic neuropathies result in optic nerve degeneration and the loss of retinal ganglion cells (RGCs) through complex signaling pathways. Although the mechanisms that regulate RGC development remain unclear, uncovering novel developmental pathways may support new strategies to regenerate the optic nerve or replace RGCs. Here we review recent studies that provide strong evidence that the Sry-related high-mobility-group C (SoxC) subfamily of transcription factors (TFs) are necessary and sufficient for axon guidance and RGC fate specification...
July 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28841206/overexpression-of-sox4-correlates-with-poor-prognosis-of-acute-myeloid-leukemia-and-is-leukemogenic-in-zebrafish
#18
J-W Lu, M-S Hsieh, H-A Hou, C-Y Chen, H-F Tien, L-I Lin
The SOX4 transcription factor is a key regulator of embryonic development, cell-fate decision, cellular differentiation and oncogenesis. Abnormal expression of SOX4 is related to malignant tumor transformation and cancer metastasis. However, no reports are available regarding the clinical significance of SOX4 in acute myeloid leukemia (AML) and the role of SOX4 in leukemogenesis. In the current study, we found that AML patients with low bone marrow (BM) SOX4 expression had higher remission rates and longer overall survival than those with high SOX4 expression, regardless of age, white blood cell count at diagnosis, karyotype profile and NPM1/FLT3-ITD status...
August 25, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28837676/alk-signaling-cascade-confers-multiple-advantages-to-glioblastoma-cells-through-neovascularization-and-cell-proliferation
#19
Risako Chiba, Masashi Akiya, Miki Hashimura, Yasuko Oguri, Madoka Inukai, Atsuko Hara, Makoto Saegusa
Anaplastic lymphoma kinase (ALK), which is a receptor tyrosine kinase, is essentially and transiently expressed in the developing nervous system. Here we examined the functional role of the ALK gene in glioblastomas (GBMs). In clinical samples of GBMs, high ALK expression without gene rearrangements or mutations was frequently observed in perivascular lesions, in contrast to the relatively low expression in the perinecrotic areas, which was positively correlated with N-myc and phosphorylated (p) Stat3 scores and Ki-67 labeling indices...
2017: PloS One
https://www.readbyqxmd.com/read/28810927/stat3-mediated-upregulation-of-lncrna-hoxd-as1-as-a-cerna-facilitates-liver-cancer-metastasis-by-regulating-sox4
#20
Hui Wang, Xisong Huo, Xin-Rong Yang, Jia He, Lijun Cheng, Na Wang, Xuan Deng, Haojie Jin, Ning Wang, Cun Wang, Fangyu Zhao, Jingyuan Fang, Ming Yao, Jia Fan, Wenxin Qin
BACKGROUND: Several of the thousands of human long noncoding RNAs (lncRNAs) have been functionally characterized, yet their potential involvement in hepatocellular carcinoma (HCC) remains poorly understood. METHODS: LncRNA-HOXD-AS1 was identified by microarray and validated by real-time PCR. The clinicopathological significance of HOXD-AS1 was analyzed by Kaplan-Meier method. Chromatin immunoprecipitation was conducted to examine the mechanism of HOXD-AS1 upregulation...
August 14, 2017: Molecular Cancer
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