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https://www.readbyqxmd.com/read/29775159/bioinformatics-functional-analysis-of-let-7a-mir-34a-and-mir-199a-b-reveals-novel-insights-into-immune-system-pathways-and-cancer-hallmarks-for-hepatocellular-carcinoma
#1
Bangly Soliman, Ahmed Salem, Mohamed Ghazy, Nourhan Abu-Shahba, Mahmoud El Hefnawi
Let-7a, miR-34a, and miR-199 a/b have gained a great attention as master regulators for cellular processes. In particular, these three micro-RNAs act as potential onco-suppressors for hepatocellular carcinoma. Bioinformatics can reveal the functionality of these micro-RNAs through target prediction and functional annotation analysis. In the current study, in silico analysis using innovative servers (miRror Suite, DAVID, miRGator V3.0, GeneTrail) has demonstrated the combinatorial and the individual target genes of these micro-RNAs and further explored their roles in hepatocellular carcinoma progression...
May 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29767266/inhibition-of-sox4-induces-melanoma-cell-apoptosis-via-downregulation-of-nf-%C3%AE%C2%BAb-p65-signaling
#2
Qiong Cheng, Juan Du, Lin Xie, Xiao Liu, Zheng Li, Fuguo Zuo, Jinfeng Wu, Jinhua Xu
SOX4 (SRY Box 4) has attracted attention due to its important effects on cell growth, proliferation and apoptosis, among other cellular processes. However, the role of SOX4 in melanoma cell apoptosis remains unclear. In the present study, we investigated whether inhibition of SOX4 induces melanoma cell apoptosis, and explored the possible mechanism involving the NF-κB signaling pathway. SOX4 was knocked down using a lentivirus in melanoma A2058 and SK-MEL-5 cell lines. Cell proliferation was measured by MTT assay...
May 16, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29762675/rxr-ligands-modulate-thyroid-hormone-signaling-competence-in-young-xenopus-laevis-tadpoles
#3
Brenda J Mengeling, Michael L Goodson, J David Furlow
Appropriate thyroid hormone (TH) signaling through thyroid hormone receptors (TRs) is essential for vertebrate development. Amphibian metamorphosis is initiated and sustained through the action of TH on TRs which are conserved across vertebrates. TRs heterodimerize with retinoid-X receptors (RXRs) on thyroid hormone-response elements (TREs) in the genome, yet in most cell line and adult animal studies, RXR ligands do not affect expression of TR target genes. We used a quantitative, precocious metamorphosis assay to interrogate the effects of the RXR agonist bexarotene (Bex) and the RXR antagonist UVI 3003 (UVI) on T3-induced resorption phenotypes in Xenopus laevis tadpoles one-week post-fertilization...
May 11, 2018: Endocrinology
https://www.readbyqxmd.com/read/29760954/the-p53-activator-overcomes-resistance-to-alk-inhibitors-by-regulating-p53-target-selectivity-in-alk-driven-neuroblastomas
#4
Makoto Miyazaki, Ryo Otomo, Yuko Matsushima-Hibiya, Hidenobu Suzuki, Ayana Nakajima, Naomi Abe, Arata Tomiyama, Koichi Ichimura, Koichi Matsuda, Toshiki Watanabe, Takahiro Ochiya, Hitoshi Nakagama, Ryuichi Sakai, Masato Enari
Anaplastic lymphoma kinase (ALK) is an oncogenic receptor tyrosine kinase that is activated by gene amplification and mutation in neuroblastomas. ALK inhibitors can delay the progression of ALK-driven cancers, but are of limited use owing to ALK inhibitor resistance. Here, we show that resistance to ALK inhibitor in ALK-driven neuroblastomas can be attenuated by combination treatment with a p53 activator. Either ALK inhibition or p53 activator treatment induced cell cycle arrest, whereas combination treatment induced apoptosis, and prevented tumour relapse both in vitro and in vivo...
2018: Cell Death Discovery
https://www.readbyqxmd.com/read/29760557/uca1-promotes-cell-proliferation-and-invasion-and-inhibits-apoptosis-through-regulation-of-the-mir129-sox4-pathway-in-renal-cell-carcinoma
#5
Qian Liu, Yang Li, Weiling Lv, Guangwei Zhang, Xin Tian, Xiaodong Li, Hepeng Cheng, Chaoyang Zhu
Background: Renal cell carcinoma (RCC) is the most common cancer in kidney malignancies. UCA1 has been identified as an oncogenic lncRNA in multiple cancers, including RCC. However, the underlying molecular mechanism of UCA1 involved in RCC progression is far from being addressed. Methods: Reverse-transcription quantitative polymerase chain reaction (RT-qPCR) assays were used to measure expressions of UCA1, miR129, and SOX4 mRNA. Western blot assays were employed to detect SOX4 protein expression...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29749639/the-homeodomain-transcription-factor-prox1-is-a-direct-target-of-soxc-proteins-during-developmental-vertebrate-neurogenesis
#6
Anne Jacob, Hannah M Wüst, Johannes M Thalhammer, Franziska Fröb, Melanie Küspert, Simone Reiprich, Elli-Anna Balta, D Chichung Lie, Michael Wegner, Elisabeth Sock
The high-mobility-group-domain containing SoxC transcription factors Sox4 and Sox11 are expressed and required in the vertebrate central nervous system in neuronal precursors and neuroblasts. To identify genes that are widely regulated by SoxC proteins during vertebrate neurogenesis we generated expression profiles from developing mouse brain and chicken neural tube with reduced SoxC expression and found the transcription factor Prox1 strongly downregulated under both conditions. This led us to hypothesize that Prox1 expression depends on SoxC proteins in the developing central nervous system of mouse and chicken...
May 11, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29749512/mir%C3%A2-188-suppresses-tumor-progression-by-targeting-sox4-in-pediatric-osteosarcoma
#7
Lu Pan, Lingxin Meng, Feng Liang, Li Cao
microRNA‑188 (miR‑188) acts as a tumor suppressor in various types of human cancer, including glioma, oral squamous cell carcinoma and hepatocellular carcinoma. However, the function and mechanism of miR‑188 in pediatric osteosarcoma (OS) have yet to be investigated. In the present study reverse transcription‑quantitative polymerase chain reaction revealed that miR‑188 expression was significantly downregulated in pediatric OS tissues and cell lines. miR‑188 overexpression markedly suppressed OS cell proliferation, migration and invasion, and induced cellular apoptosis...
May 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29734873/whole-exome-sequencing-of-sinonasal-small-cell-carcinoma-arising-within-a-papillary-schneiderian-carcinoma-in-situ
#8
Joshua Smith, Aditi Kulkarni, Andrew C Birkeland, Jonathan B McHugh, J Chad Brenner
Objective The pathogenetic underpinnings of extrapulmonary small cell carcinomas (EPSCCs) of the head and neck are poorly understood. We sought to describe the clinical case and whole-exome DNA sequencing data of a patient with sinonasal Schneiderian carcinoma in situ whose tumor progressed to small cell carcinoma (SCC). Study Design Case report and whole-exome sequencing of tumor DNA. Setting Academic medical center. Subjects and Methods A 52-year-old man with sinonasal Schneiderian carcinoma in situ whose tumor progressed to small cell carcinoma...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29731815/oral-lichen-planus-and-malignant-transformation-the-role-of-p16-ki-67-bub-3-and-sox4-in-assessing-precancerous-potential
#9
Eduardo Augusto Rosa, Aura Maria Hurtado-Puerto, Denise Pinheiro Falcão, Aline Patricia Brietzke, Luiz Eduardo De Almeida Prado Franceschi, Florlorêncio Figueiredo Cavalcanti Neto, Valdenize Tiziane, Fabiana Pirani Carneiro, Evelyn Mikaela Kogawa, Heitor Moreno, Rivadávio Fernandes Batista Amorim
The association of oral lichen planus (OLP) lesions with malignant transformation risk has remained a controversial topic and is of clinical importance. Therefore, the present study evaluated the expression levels of p16, Ki-67, budding uninhibited by benzimidazoles 3 (Bub-3) and sex-determining region Y-related high mobility group box 4 (SOX4), and their roles as precancerous biomarkers in OLP. A retrospective study was performed, in which tissue blocks of OLP, oral dysplasia (OD), cutaneous lichen planus (CLP) and oral fibrous hyperplasia (OFH) were used (n=120)...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29693704/lncsox4-serves-an-oncogenic-role-in-the-tumorigenesis-of-epithelial-ovarian-cancer-by-promoting-cell-proliferation-and-inhibiting-apoptosis
#10
Yulan Liu, Yan Wang, Dongmei Yao, Diansheng Cui
Epithelial ovarian cancer is one of the primary causes of gynecological cancer mortality. Increasing evidence has suggested that long non‑coding RNAs (lncRNAs) may serve a pivotal role in cancer development. To determine whether Lnc SRY‑box 4 (SOX4), an lncRNA, promotes the self‑renewal of liver tumor cells and contributes to the development of epithelial ovarian cancer, the present study investigated the expression of LncSOX4 in clinical epithelial ovarian cancer tissues and non‑cancer controls by reverse transcription‑quantitative polymerase chain reaction analysis...
April 18, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29684587/trpm7-controls-mesenchymal-features-of-breast-cancer-cells-by-tensional-regulation-of-sox4
#11
Arthur J Kuipers, Jeroen Middelbeek, Kirsten Vrenken, Carlos Pérez-González, Geert Poelmans, Jeffrey Klarenbeek, Kees Jalink, Xavier Trepat, Frank N van Leeuwen
Mechanically induced signaling pathways are important drivers of tumor progression. However, if and how mechanical signals affect metastasis or therapy response remains poorly understood. We previously found that the channel-kinase TRPM7, a regulator of cellular tension implicated in mechano-sensory processes, is required for breast cancer metastasis in vitro and in vivo. Here, we show that TRPM7 contributes to maintaining a mesenchymal phenotype in breast cancer cells by tensional regulation of the EMT transcription factor SOX4...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29676203/-5p-and-3p-strands-of-mir-145-and-mir-140-during-mesenchymal-stem-cell-chondrogenic-differentiation
#12
Jonathan D Kenyon, Olga Sergeeva, Rodrigo A Somoza, Ming Li, Arnold I Caplan, Ahmad M Khalil, Zhenghong Lee
The chondrogenic differentiation of mesenchymal stem cells (MSCs) is mediated by transcription factors and small non-coding RNAs such as micro-RNAs (miRNAs). Each miRNA is initially transcribed as a long transcript, which matures to produce -5p and -3p strands. It is widely believed that the mature and functional miRNA from any given pre-miRNA, usually the -5p strand, is functional, while the opposing -3p strand is degraded. However, recent cartilage literature started to show functional -3p stands for a few miRNAs...
April 20, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29490000/propofol-inhibits-proliferation-migration-and-invasion-but-promotes-apoptosis-by-regulation-of-sox4-in-endometrial-cancer-cells
#13
Qing Du, Jia Liu, Xuezhi Zhang, Xin Zhang, He Zhu, Ming Wei, Shilei Wang
Propofol is an intravenous sedative hypnotic agent of which the growth-inhibitory effect has been reported on various cancers. However, the roles of propofol in endometrial cancer (EC) remain unclear. This study aimed to explore the effects of propofol on EC in vitro and in vivo. Different concentrations of propofol were used to treat Ishikawa cells. Colony number, cell viability, cell cycle, apoptosis, migration, and invasion were analyzed by colony formation, MTT, flow cytometry, and Transwell assays. In addition, the pcDNA3...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29484115/transcriptomes-define-distinct-subgroups-of-salivary-gland-adenoid-cystic-carcinoma-with-different-driver-mutations-and-outcomes
#14
Candace A Frerich, Kathryn J Brayer, Brandon M Painter, Huining Kang, Yoshitsugu Mitani, Adel K El-Naggar, Scott A Ness
The relative rarity of salivary gland adenoid cystic carcinoma (ACC) and its slow growing yet aggressive nature has complicated the development of molecular markers for patient stratification. To analyze molecular differences linked to the protracted disease course of ACC and metastases that form 5 or more years after diagnosis, detailed RNA-sequencing (RNA-seq) analysis was performed on 68 ACC tumor samples, starting with archived, formalin-fixed paraffin-embedded (FFPE) samples up to 25 years old, so that clinical outcomes were available...
January 26, 2018: Oncotarget
https://www.readbyqxmd.com/read/29471893/mir-363-3p-inhibits-osteosarcoma-cell-proliferation-and-invasion-via-targeting-sox4
#15
Kejun Wang, Lin Yan, Fen Lu
MiR-363-3p has been proven to suppress tumor growth and metastasis in various human cancers. However, the function of miR-363-3p in osteosarcoma (OS) has not been determined. In our study, we found that the expression of miR-363-3p was significantly downregulated in OS tissues compared with adjacent normal tissues. And miR-363-3p expression was associated with the poor overall survival rate of OS patients. Moreover, we found that overexpression of miR-363-3p markedly inhibited the proliferation, migration and invasion of U2OS and MG63 cells...
February 22, 2018: Oncology Research
https://www.readbyqxmd.com/read/29442040/lidocaine-sensitizes-the-cytotoxicity-of-5-fluorouacil-in-melanoma-cells-via-upregulation-of-microrna-493
#16
Yingbin Wang, Jianqin Xie, Wei Liu, Rongzhi Zhang, Shenghui Huang, Yanhong Xing
Lidocaine is a well-documented local anesthetic that has been reported to sensitize the cytotoxicity of cisplatin in cancer cells. However, little information is available concerning whether lidocaine sensitizes the cytotoxicity of 5-fluorouracil (5-FU) in melanoma cells. The study was aimed to explore the effects and mechanisms of lidocaine on the sensitivity to 5-FU in the melanoma cell line SK-MEL-2. Cell viability and apoptosis were analyzed after administration of different concentrations of lidocaine, 5-FU, or the combinations...
November 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441981/long-non-coding-rna-sox4-promotes-proliferation-and-migration-by-activating-wnt-%C3%AE-catenin-signaling-pathway-in-osteosarcoma
#17
Zhoubin Tian, Guang Yang, Peng Jiang, Laibo Zhang, Jian Wang, Shui Sun
Osteosarcoma is a bone tumor without effective treatment in the world. Recently, long non-coding RNAs (lncRNAs) are considered as essential regulators in cancer progression. LncSox4 plays crucial roles in liver tumor-initiating cells self-renewal and tumor initiation. However, the effect of lncSox4 in osteosarcoma remains largely unclear. Quantitative real-time PCR (qRT-PCR) and Northern blot were performed to detect lncSox4 expressions in osteosarcoma. The functions of lncSox4 in osteosarcoma were determined using cell viability and migration assays...
September 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29436190/long-non-coding-rna-tug1-promotes-proliferation-and-inhibits-apoptosis-of-osteosarcoma-cells-by-sponging-mir-132-3p-and-upregulating-sox4-expression
#18
Gang Li, Keyu Liu, Xinhui Du
PURPOSE: Long non-coding RNA taurine upregulated gene 1 (TUG1) is reported to be a vital regulator of the progression of various cancers. This study aimed to explore the exact roles and molecular mechanisms of TUG1 in osteosarcoma (OS) development. MATERIALS AND METHODS: Real-time quantitative PCR was applied to detect the expressions of TUG1 and microRNA-132-3p (miR-132-3p) in OS tissues and cells. Western blot was performed to measure protein levels of sex determining region Y-box 4 (SOX4)...
March 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29403086/association-of-cdkal1-nucleotide-variants-with-the-risk-of-non-syndromic-cleft-lip-with-or-without-cleft-palate
#19
Agnieszka Gaczkowska, Kacper Żukowski, Barbara Biedziak, Kamil K Hozyasz, Piotr Wójcicki, Małgorzata Zadurska, Margareta Budner, Agnieszka Lasota, Anna Szponar-Żurowska, Paweł P Jagodziński, Adrianna Mostowska
Although the aetiology of non-syndromic cleft lip with or without cleft palate (nsCL/P) has been studied extensively, knowledge regarding the role of genetic factors in the pathogenesis of this common craniofacial anomaly is still limited. We conducted a follow-up association study to confirm that CDKAL1 nucleotide variants identified in our genome-wide association study (GWAS) for nsCL/P are associated with the risk of this anomaly. In addition, we performed a sequence analysis of the selected CDKAL1 exons...
April 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29398692/lncrna-bg981369-inhibits-cell-proliferation-migration-and-invasion-and-promotes-cell-apoptosis-by-sry-related-high-mobility-group-box-4-sox4-signaling-pathway-in-human-gastric-cancer
#20
Xiuli Dong, Renpin Chen, Haihua Lin, Tiesu Lin, Shuang Pan
BACKGROUND Human gastric cancer (GC) is a leading primary cause of cancer-associated deaths in both males and females worldwide. However, there are few effective diagnostic and therapeutic measures for GC patients due to the complicated underlying mechanisms of GC. Recently, increasing research has indicated that lncRNAs may play a critical role in the progression of GC. MATERIAL AND METHODS AI769947, AK054978, DB077273, BG981369, AK054588, and AF131784 expressions were analyzed by qRT-PCR assay in GC tissues and corresponding normal tissues (n=44)...
February 5, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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