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https://www.readbyqxmd.com/read/27883116/zabofloxacin-for-chronic-bronchitis
#1
B Kocsis, D Szabo
Treatment of lower respiratory tract infection poses as an ongoing challenge among respiratory tract diseases. Bacterial infections are causes of acute exacerbations in chronic bronchitis and indications for antibacterial therapy. Several antibiotics were applied to treat bacterial infections in chronic bronchitis, among them fluoroquinolones are considered potent, broad-spectrum agents with excellent tissue penetration. This monograph focuses on zabofloxacin, a novel fluoroquinolone agent recently approved and launched in South Korea, and summarizes the drug's antibacterial efficacy, pharmacokinetic properties and toxicity...
September 2016: Drugs of Today
https://www.readbyqxmd.com/read/27857841/relationship-between-sleep-characteristics-and-measures-of-body-size-and-composition-in-a-nationally-representative-sample
#2
Qian Xiao, Fangyi Gu, Neil Caporaso, Charles E Matthews
BACKGROUND: Short sleep has been linked to obesity. However, sleep is a multidimensional behavior that cannot be characterized solely by sleep duration. There is limited study that comprehensively examined different sleep characteristics in relation to obesity. METHODS: We examined various aspects of sleep in relation to adiposity in 2005-2006 NHANES participants who were 18 or older and free of cardiovascular disease, cancer, emphysema, chronic bronchitis and depression (N = 3995)...
2016: BMC Obesity
https://www.readbyqxmd.com/read/27855145/potentially-preventable-deaths-among-the-five-leading-causes-of-death-united-states-2010-and-2014
#3
Macarena C García, Brigham Bastian, Lauren M Rossen, Robert Anderson, Arialdi Miniño, Paula W Yoon, Mark Faul, Greta Massetti, Cheryll C Thomas, Yuling Hong, Michael F Iademarco
Death rates by specific causes vary across the 50 states and the District of Columbia.* Information on differences in rates for the leading causes of death among states might help state health officials determine prevention goals, priorities, and strategies. CDC analyzed National Vital Statistics System data to provide national and state-specific estimates of potentially preventable deaths among the five leading causes of death in 2014 and compared these estimates with estimates previously published for 2010...
November 18, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27855141/announcement-national-chronic-obstructive-pulmonary-disease-awareness-month-november-2016
#4
(no author information available yet)
Approximately 15.7 million U.S. adults have received a diagnosis of chronic obstructive pulmonary disease (COPD), which includes chronic bronchitis and emphysema (1). However, many more adults with symptoms of COPD, including frequent coughing, shortness of breath, excess phlegm or sputum production, wheezing, or difficulty taking a deep breath, might not be aware that they have COPD, or they may not be receiving treatment for COPD because they have never received a diagnosis. Geographic variations in the availability of primary care physicians and COPD specialists for the U...
November 18, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27843852/prevalence-of-chronic-respiratory-disorders-in-a-rural-area-of-north-west-india-a-population-based-study
#5
Vinod Sharma, Rajiv Kumar Gupta, D S Jamwal, Sunil Kumar Raina, Bhavana Langer, Rashmi Kumari
INTRODUCTION: Chronic respiratory diseases are an important cause of disability across the globe. The global burden of these diseases is showing a discernible upward trend. It is estimated that 500 million people suffer from them. MATERIALS AND METHODS: The study was conducted with the aim to estimate the prevalence of chronic obstructive pulmonary disease (COPD) in a rural Indian population. For this, a population-based survey was conducted using modified British Medical Research Council questionnaire...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27836541/substituted-e-2-2-benzylidenehydrazinyl-4-methylthiazole-5-carboxylates-as-dual-inhibitors-of-15-lipoxygenase-carbonic-anhydrase-ii-synthesis-biological-evaluation-and-docking-studies
#6
Aamer Saeed, Shafi Ullah Khan, Parvez Ali Mahesar, Pervaiz Ali Channar, Ghulam Shabir, Jamshed Iqbal
15-Lipoxygenase (15-LOX) plays a major role in many inflammatory lung diseases including chronic obstructive pulmonary disease (COPD), asthma and chronic bronchitis. Over-expression of 15-LOX is related with some specific carcinomas including pancreatic, gastric and brain tumor. Similarly among different isozymes of carbonic anhydrase (CA), CA II is expressed in pancreatic, gastric carcinomas as well as in brain tumors. Therefore, novel potent inhibitors of both 15-LOX and CA II are required to explore the role of these enzymes further and to enable the drug discovery efforts...
November 8, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27826883/cigarette-smoking-and-respiratory-system-diseases-in-adolescents
#7
REVIEW
Agnieszka Saracen
Respiratory system diseases are common in youngsters, smoking being one of the main cause of them. In this article, results are presented of a survey-type study on smoking and respiratory malady conducted in 3108 high school students from the Mazovian Region in Poland. The questionnaire made for this study contained questions concerning the health status, chronic diseases, and the cigarette smoking habit. The subjects were high school student aged 15-19. Overall, 1694 males and 1414 females were enrolled in the study...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27821620/tnf-up-regulates-st3gal4-and-sialyl-lewisx-expression-in-lung-epithelial-cells-through-an-intronic-atf2-responsive-element
#8
Florent Colomb, Marie-Ange Krzewinski-Recchi, Agata Steenackers, Audrey Vincent, Anne Harduin-Lepers, Philippe Delannoy, Sophie Groux-Degroote
We have previously shown that TNF induced the up-regulation of the sialyltransferase gene ST3GAL4 BX transcript through mitogen- and stress-activated kinase 1/2 (MSK1/2), extracellular-signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) signaling pathways. This up-regulation resulted in sialyl-Lewis(x) (sLe(x)) over-expression on high-molecular weight glycoproteins in inflamed airway epithelium and increased the adhesion of Pseudomonas aeruginosa PAO1 and PAK strains to lung epithelial cells...
November 7, 2016: Biochemical Journal
https://www.readbyqxmd.com/read/27806211/electronic-cigarette-use-and-respiratory-symptoms-in-adolescents
#9
Rob McConnell, Jessica L Barrington-Trimis, Kejia Wang, Robert Urman, Hanna Hong, Jennifer Unger, Jonathan Samet, Adam Leventhal, Kiros Berhane
BACKGROUND: Rates of adolescent electronic (e-) cigarette use are increasing, but there has been little study of the chronic effects of use. Components of e-cigarette aerosol have known pulmonary toxicity. METHODS: Associations of self-reported use of e-cigarettes with chronic bronchitic symptoms (chronic cough, phlegm or bronchitis) and of wheeze in the previous 12 months were examined in 2086 Southern California Children's Health Study participants completing questionnaires in 11th and 12th grade in 2014...
November 2, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27795984/pulmonary-predictors-of-incident-diabetes-in-smokers
#10
Gregory L Kinney, Emma H Baker, Oana L Klein, Jennifer L Black-Shinn, Emily S Wan, Barry Make, Elizabeth Regan, Russell P Bowler, Sharon M Lutz, Kendra A Young, Lindsey M Duca, George R Washko, Edwin K Silverman, James D Crapo, John E Hokanson
BACKGROUND: Diabetes mellitus and its complications are a large and increasing burden for health care worldwide. Reduced pulmonary function has been observed in diabetes (both type 1 and type 2), and this reduction is thought to occur prior to diagnosis. Other measures of pulmonary health are associated with diabetes, including lower exercise tolerance, greater dyspnea, lower quality of life (as measured by the St. George's Respiratory Questionaire [SGRQ]) and susceptibility to lung infection and these measures may also predate diabetes diagnosis...
2016: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://www.readbyqxmd.com/read/27794529/bronchiectasis-and-aspergillus-how-are-they-linked
#11
Anthony De Soyza, Stefano Aliberti
Bronchiectasis is a chronic airway infection syndrome, distinct from cystic fibrosis that is rising in prevalence and is associated with significant morbidity and mortality. It can be caused by many etiologies including post-infectious effects or be seen in common lung diseases such as chronic obstructive pulmonary disease (COPD) or severe asthma. Bronchiectasis is associated with many Aspergillus-associated syndromes: allergic bronchopulmonary aspergillosis (ABPA) may complicate asthma, thus leading to bronchiectasis as part of the diagnostic criteria of ABPA or can complicate preexisting bronchiectasis due to another etiology...
October 28, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27790272/a-mitochondrial-perspective-of-chronic-obstructive-pulmonary-disease-pathogenesis
#12
REVIEW
Min-Jong Kang, Gerald S Shadel
Chronic obstructive pulmonary disease (COPD) encompasses several clinical syndromes, most notably emphysema and chronic bronchitis. Most of the current treatments fail to attenuate severity and progression of the disease, thereby requiring better mechanistic understandings of pathogenesis to develop disease-modifying therapeutics. A number of theories on COPD pathogenesis have been promulgated wherein an increase in protease burden from chronic inflammation, exaggerated production of reactive oxygen species and the resulting oxidant injury, or superfluous cell death responses caused by enhanced cellular injury/damage were proposed as the culprit...
October 2016: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27788254/microorganisms-causing-community-acquired-acute-bronchitis-the-role-of-bacterial-infection
#13
Ji Young Park, Sunghoon Park, Sun Hwa Lee, Myung Goo Lee, Yong Bum Park, Kil Chan Oh, Jae-Myung Lee, Do Il Kim, Ki-Hyun Seo, Kyeong-Cheol Shin, Kwang Ha Yoo, Yongchun Ko, Seung Hun Jang, Ki-Suck Jung, Yong Il Hwang
BACKGROUND: Although acute bronchitis is quite common, there is relatively limited information regarding the microorganisms that are involved in this illness. METHODS: We performed a prospective study of acute bronchitis at 31 hospitals and clinics in Korea from July 2011 to June 2012. Sputum specimens were collected for polymerase chain reaction (PCR) and culture of microorganisms. RESULTS: Of the 811 enrolled patients, 291 had acceptable sputum specimens that were included for analysis of the etiologic distribution...
2016: PloS One
https://www.readbyqxmd.com/read/27780090/a-case-of-obturator-hernia-leading-to-right-thigh-abscess-in-china
#14
Zhen Shen, Chen-Yang Zhi, Ruo-Nan Wang, Hai-Cheng Gao
The purpose of this case is to investigate a case of obturator hernia leading to right thigh abscess on 68-year-old woman of China. A 68-year-old Chinese woman was referred to China-Japan Friendship Hospital of Jilin University with abdominal pain, bloating, exhaust, stop defecation in 2011. She had chronic bronchitis, emphysema with a history of 20 years. This patient did not have any bad habits, such as smoking, alcohol consumption, etc. In this surgery, CT was used to diagnose the basic condition of the patient...
October 19, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27778272/urinary-polyaromatic-hydrocarbons-are-associated-with-adult-emphysema-chronic-bronchitis-asthma-and-infections-us-nhanes-2011-2012
#15
Ivy Shiue
Links between environmental chemicals and human health have emerged over the last few decades, but the effects from polyaromatic hydrocarbons were less studied, compared to other commonly known environmental chemicals such as heavy metals, phthalates, arsenic, phenols, pesticides, etc. Therefore, the aim of the study was to examine the relationships of urinary polyaromatic hydrocarbons and adult respiratory health conditions using a large human sample in a national and population-based setting in recent years...
October 24, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27778265/synchronous-dynamic-research-on-respiratory-and-intestinal-microflora-of-chronic-bronchitis-rat-model
#16
Xiu-Li Zheng, Yu Yang, Bao-Jia Wang, Ju Wang, Hong-Qu Tang
OBJECTIVE: To investigate the mechanism of the Chinese medicine theory that Fei (Lung) and Dachang (Large Intestine) are exteriorly and interiorly related via synchronous observation on the dynamic changes of the respiratory and intestinal microflora. METHODS: Forty specific pathogen free Sprague-Dawley rats were selected and randomly divided into blank (10 rats) and chronic bronchitis model groups (30 rats). The blank group rats were put into the smoke-free environment and the model group rats were put into the smoke environment in order to establish pulmonary disease (chronic bronchitis) model...
October 24, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27770532/impact-of-some-environmental-factors-on-human-health
#17
N Lomtatidze, G Dumbadze, M Chkhaidze, R Khakhnelidze
This paper presents statistical data of 2012-2015 on the diseases caused by the atmospheric air and water pollutions in Ajara region. The research on the content of dust, sulfur dioxide and nitrogen dioxide as well as carbon monoxide in the atmospheric air was held together with the National Environment Agency Ajara Monitoring Service. The results of the research have shown that the average content of the dust reached its maximum in 2012 (0.60 mg/m3) and it dropped to the minimum in 2015 (0.441 mg/m3). As for average content of carbon monoxide the maximum was observed in 2013 (3...
September 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27766323/development-of-a-functional-point-of-need-diagnostic-for-myeloperoxidase-detection-to-identify-neutrophilic-bronchitis
#18
Michael G Wolfe, Qiang Zhang, Christy Hui, Katherine Radford, Parameswaran Nair, John D Brennan
With over 4.8 million Canadians suffering from chronic airway diseases, respiratory exacerbations are currently the leading cause of hospitalization in Canada. In cases of bacterial infection, neutrophil cell density increases from ∼10 million cells per gram to over 15 million cells per gram. As sputum is a direct discharge from the primarily affected areas of respiratory diseases, quantification of granulocytes (including neutrophils) can be used to effectively determine a course of patient treatment. Unfortunately this quantification is currently limited to labour-intensive and time-consuming cell counts...
October 21, 2016: Analyst
https://www.readbyqxmd.com/read/27763599/effect-of-cannabis-smoking-on-lung-function-and-respiratory-symptoms-a-structured-literature-review
#19
Luis Ig Ribeiro, Philip W Ind
As cannabis use increases, physicians need to be familiar with the effects of both cannabis and tobacco on the lungs. However, there have been very few long-term studies of cannabis smoking, mostly due to legality issues and the confounding effects of tobacco. It was previously thought that cannabis and tobacco had similar long-term effects as both cause chronic bronchitis. However, recent large studies have shown that, instead of reducing forced expiratory volume in 1 s and forced vital capacity (FVC), marijuana smoking is associated with increased FVC...
October 20, 2016: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/27758989/long-term-efficacy-of-macrolide-treatment-in-idiopathic-pulmonary-fibrosis-a-retrospective-analysis
#20
Naoyuki Kuse, Shinji Abe, Hiroki Hayashi, Koichiro Kamio, Yoshinobu Saito, Jiro Usuki, Arata Azuma, Shoji Kudoh, Akihiko Gemma
BACKGROUND AND OBJECTIVE: There is growing evidence for anti-inflammatory activities of macrolides in chronic respiratory diseases, such as diffuse panbronchiolitis, cystic fibrosis, or chronic bronchitis. The long-term effect of macrolides in idiopathic pulmonary fibrosis (IPF) is unknown. This study was aimed to investigate the effect of macrolide therapy on the frequency of acute exacerbation (AE) and the mortality in IPF. METHODS: A total 52 IPF patients who were treated by combination of conventional agents with or without macrolides were retrospectively reviewed...
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
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