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Persistent chronic pain

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https://www.readbyqxmd.com/read/29149149/decreased-regional-grey-matter-volume-in-women-with-chronic-whiplash-associated-disorders-relationships-with-cognitive-deficits-and-disturbed-pain-processing
#1
Iris Coppieters, Robby De Pauw, Karen Caeyenberghs, Lieven Danneels, Jeroen Kregel, Astrid Pattyn, Mira Meeus, Barbara Cagnie
BACKGROUND: Patients with chronic whiplash-associated disorders (CWAD) are characterized by pain of traumatic origin, cognitive deficits, and central sensitization (CS). Previous neuroimaging studies revealed altered grey matter volume (GMV) in mild traumatic brain injury patients and chronic pain conditions also characterized by CS. It can therefore be hypothesized that GMV alterations also play a role in the persistent complaints of CWAD. However, brain alterations remain poorly investigated in these patients...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29146590/camkii%C3%AE-mediates-the-effect-of-il-17-to-promote-ongoing-spontaneous-and-evoked-pain-in-multiple-sclerosis
#2
Xiaoyu Hu, Fang Huang, Zaijie Jim Wang
Pain is a common and severe symptom in multiple sclerosis (MS), a chronic inflammatory and demyelinating disease of the central nervous system. The neurobiological mechanism underlying MS pain is poorly understood. In this study, we investigated the role of Ca(2+)/calmodulin dependent kinase type IIα (CaMKIIα) in driving chronic pain in MS using a mouse experimental autoimmune encephalomyelitis (EAE) model. We found that spinal CaMKIIα activity was enhanced in EAE correlating with the development of ongoing spontaneous pain and evoked hypersensitivity to mechanical and thermal stimuli...
November 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29145239/two-case-reports-colorectal-adenocarcinoma-in-children
#3
Chang Hoon Ahn, Soon Chul Kim
RATIONALE: Colorectal cancer in children is rare, with delayed diagnosis and advanced stage at presentation in high mortality. Early detection of colorectal cancer is, therefore, important for better prognosis. PATIENT CONCERNS: Thirteen-year-old boy presented with symptoms of melena, vomiting, and abdominal pain for 6 months. 18-year-old girl was hospitalized due to the symptoms of hematochezia, and persistent abdominal pain for 6 months. They have no chronic disease or familial history of malignancy...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145033/is-chronic-postsurgical-pain-surgery-induced-a-study-of-persistent-postoperative-pain-following-breast-reconstruction
#4
Randy S Roth, Ji Qi, Jennifer B Hamill, Hyungjin M Kim, Tiffany N S Ballard, Andrea L Pusic, Edwin G Wilkins
BACKGROUND: Chronic postsurgical pain (CPSP) is a reported risk for women undergoing breast reconstruction, but it remains unclear that such persistent pain is induced by reconstructive surgery. To address this concern, this prospective cohort study examined the prevalence of and risk factors associated with CPSP among women undergoing breast reconstruction. MATERIALS AND METHODS: Women (n = 1996) recruited for the Mastectomy Reconstruction Outcomes Consortium (MROC) Study were assessed preoperatively and at two-years postoperatively for relevant medical/...
November 13, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29145012/the-gut-brain-interaction-in-opioid-tolerance
#5
REVIEW
Hamid I Akbarali, William L Dewey
The prevailing opioid crisis has necessitated the need to understand mechanisms leading to addiction and tolerance, the major contributors to overdose and death and to develop strategies for developing drugs for pain treatment that lack abuse liability and side-effects. Opioids are commonly used for treatment of pain and symptoms of inflammatory bowel disease. The significant effect of opioids in the gut, both acute and chronic, includes persistent constipation and paradoxically may also worsen pain symptoms...
November 13, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29141716/hansen-s-disease-and-rheumatoid-arthritis-crossover-of-clinical-symptoms-a-case-series-of-18-patients-in-the-united-states
#6
Sarah M Labuda, John S Schieffelin, Jeffrey G Shaffer, Barbara M Stryjewska
Hansen's Disease (HD) is a rare, chronic granulomatous infection of the skin and peripheral nerves caused by the noncultivable organism Mycobacterium leprae. Arthritis is the third most common symptom of HD. Subjects with both confirmed HD on skin biopsy and chronic arthritis were identified at the National Hansen's Disease Program (NHDP). We conducted a series of medical chart reviews and extracted and logged personally deidentified data into a database and carried out descriptive analyses. Eighteen of 261 subjects presented to the NDHP with both HD and chronic arthritis between 2001 and 2015...
October 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29140934/response-of-symptomatic-persistent-chronic-disseminated-candidiasis-to-corticosteroid-therapy-in-immunosuppressed-pediatric-patients-case-study-and-review-of-the-literature
#7
Vered Shkalim-Zemer, Itzhak Levi, Salvador Fischer, Hannah Tamary, Joanne Yakobovich, Gali Avrahami, Gil Gilad, Sara Elitzur, Isaac Yaniv, Ronit Elhasid, Michal Manistersky, Itamar Shalit
BACKGROUND: Chronic disseminated candidiasis (CDC) is a severe invasive fungal infection principally observed during neutrophil recovery in patients with acute leukemia treated with intensive chemotherapy. Its pathophysiology remains unclear. We describe the management of six children with symptomatic CDC who did not respond to antifungal therapy. METHODS: The databases of the hematology-oncology departments of two tertiary pediatric medical centers were searched for all patients diagnosed with CDC from 2003 to 2015 who responded to corticosteroids after failing antifungal therapy...
November 14, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29139566/patient-reported-rates-of-chronic-pain-and-recurrence-after-groin-hernia-repair
#8
K-J Lundström, H Holmberg, A Montgomery, P Nordin
BACKGROUND: The effectiveness of different procedures in routine surgical practice for hernia repair with respect to chronic postoperative pain and reoperation rates is not clear. METHODS: This was prospective cohort study based on a unique combination of patient-reported outcomes and national registry data. Virtually all patients with a groin hernia repair in Sweden between September 2012 and April 2015 were sent a questionnaire 1 year after surgery. Persistent pain, defined as at least 'pain present, cannot be ignored, and interferes with concentration on everyday activities' in the past week was the primary outcome...
November 15, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29138961/blastocystis-subtypes-isolated-from-irritable-bowel-syndrome-patients-and-co-infection-with-helicobacter-pylori
#9
Ayman A El-Badry, Wegdan M Abd El Wahab, Doaa A Hamdy, Alaa Aboud
Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disease presenting clinically by abdominal pain with alteration of bowel habits. Although IBS has uncertain etiology, chronic gut inflammation due to persistent exposure to an infectious agent including Blastocystis sp. was proposed. The aim of this study was to detect the prevalence of Blastocystis sp. subtype (ST) isolated from stool of IBS patients and to assess Blastocystis sp. and H. pylori co-infection in IBS patients from Beni-Suef Governorate, Egypt...
November 14, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29136315/deficient-pain-modulation-in-patients-with-a-chronic-hemiplegic-shoulder-pain
#10
Yafit Kashi, Motti Ratmansky, Ruth Defrin
BACKGROUND: Hemiplegic Shoulder Pain (HSP) following stroke significantly affects the individual's function and quality of life. The mechanism of HSP is not clearly understood, hence it is unclear why HSP resolves spontaneously or following routine care in some patients, while in others it becomes persistent. The aim was therefore, to study whether HSP is associated with deficient pain modulation. METHODS: Thirty post-stroke patients; 16 with HSP and 14 without HSP, and 20 matched controls participated...
November 14, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29130879/vascularized-medial-femoral-condyle-graft-for-manubrium-nonunion-case-report-and-review-of-the-literature
#11
William R Aibinder, Michael E Torchia, Allen T Bishop, Alexander Y Shin
Fractures of the sternum are rare. Persistent nonunions, however, can lead to chronic pain and significant functional limitations. The vascularized medial femoral condyle is a versatile tool in the surgeon's armamentarium. Traditionally, it has been used as a thin corticoperiosteal graft in the treatment of nonunion of tubular bones. Its use as a structural corticocancellous graft has also been expanding. This report presents a case of a patient with a recalcitrant symptomatic nonunion of the manubrium treated with the unique combined corticoperiosteal and corticocancellous vascularized bone graft from the medial femoral condyle and reviews the literature concerning these uncommon nonunions...
October 2017: Journal of Surgical Orthopaedic Advances
https://www.readbyqxmd.com/read/29127574/biologic-treatment-for-chronic-recurrent-multifocal-osteomyelitis-report-of-four-cases-and-review-of-the-literature
#12
REVIEW
Elena Tronconi, Angela Miniaci, Michelangelo Baldazzi, Laura Greco, Andrea Pession
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare non-infectious inflammatory disorder with unpredictable clinical course, characterized by acute exacerbations and spontaneous remissions. There are no randomized-controlled trials about treatment options. Non-steroidal anti-inflammatory drugs (NSAID) are the first-line treatment option; glucocorticoids seem to be effective; positive outcomes have been obtained with bisphosphonates. In the last few years successful use of biologic agents like anti-TNF agents has been reported...
November 11, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29126847/visualization-of-painful-inflammation-in-patients-with-pain-after-traumatic-ankle-sprain-using-11-c-d-deprenyl-pet-ct
#13
Mikko Aarnio, Lieuwe Appel, Mats Fredrikson, Torsten Gordh, Olof Wolf, Jens Sörensen, Måns Thulin, Magnus Peterson, Clas Linnman
BACKGROUND AND AIMS: Positron emission tomography (PET) with the radioligand [(11)C]-D-deprenyl has shown increased signal at location of pain in patients with rheumatoid arthritis and chronic whiplash injury. The binding site of [(11)C]-D-deprenyl in peripheral tissues is suggested to be mitochondrial monoamine oxidase in cells engaged in post-traumatic inflammation and tissue repair processes. The association between [(11)C]-D-deprenyl uptake and the transition from acute to chronic pain remain unknown...
November 7, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29124418/the-effect-of-pre-transplant-pain-and-chronic-disease-self-efficacy-on-quality-of-life-domains-in-the-year-following-hematopoietic-stem-cell-transplantation
#14
Madeline L O'Sullivan, Rebecca A Shelby, Caroline S Dorfman, Sarah A Kelleher, Hannah M Fisher, Krista A Rowe Nichols, Francis J Keefe, Anthony D Sung, Tamara J Somers
PURPOSE: Pain is common for hematopoietic stem cell transplant (HSCT) patients and may be experienced pre-transplant, acutely post-transplant, and for months or years following transplant. HSCT patients with persistent pain may be at risk for poor quality of life following transplant; however, the impact of pre-transplant pain on quality of life post-transplant is not well understood. Self-efficacy for chronic disease management is associated with quality of life among cancer patients and may impact quality of life for HSCT patients...
November 9, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29123662/chronic-postsurgical-pain-is-there-a-possible-genetic-link
#15
Sabu Kumar James
Persistent or chronic postsurgical pain (CPSP) has been defined as 'pain persisting beyond 2 months'. The cut-off limit of 2 months has been controversial, and some researchers argue for a 3-month period for the definition of CPSP. Multiple mechanisms, including both patient and surgical, have been shown to influence this transition. Patient factors include age, gender, anxiety, depression, somatisation, catastrophising, pre-existing pain anywhere and pain at the site of surgery. The various surgical factors include site and nature of surgery, infection, inflammation and repeat surgery...
November 2017: British Journal of Pain
https://www.readbyqxmd.com/read/29121961/a-multicomponent-intervention-for-the-management-of-chronic-pain-in-older-adults-study-protocol-for-a-randomized-controlled-trial
#16
Sheung-Tak Cheng, Ka Long Chan, Rosanna W L Lam, Monique H T Mok, Phoon Ping Chen, Yu Fat Chow, Joanne W Y Chung, Alexander C B Law, Jenny S W Lee, Edward M F Leung, Cindy W C Tam
BACKGROUND: Studies have shown that physical interventions and psychological methods based on the cognitive behavioral approach are efficacious in alleviating pain and that combining both tends to yield more benefits than either intervention alone. In view of the aging population with chronic pain and the lack of evidence-based pain management programs locally, we developed a multicomponent intervention incorporating physical exercise and cognitive behavioral techniques and examined its long-term effects against treatment as usual (i...
November 9, 2017: Trials
https://www.readbyqxmd.com/read/29121583/a-case-report-of-gastric-lymphocytic-phlebitis-a-rare-mimic-for-malignancy
#17
Daniel L Chan, Praveen Ravindran, Dorothy Chua, Jason D Smith, King S Wong, Michael A Ghusn
INTRODUCTION: Lymphocytic phlebitis is a benign condition characterised by inflammation of the veins and rarely affects the gastrointestinal tract. Reported cases present as acute abdomen and involve the colon or small intestine. We report the fourth case of gastric lymphocytic phlebitis in the literature. PRESENTATION OF CASE: A 74-year-old female presented with eight weeks of abdominal pain. Findings at endoscopy were suggestive of a malignant ulcer on the greater curvature of antrum, while biopsies showed chronic gastritis without malignancy...
November 2, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29120944/targeted-genotyping-identifies-susceptibility-locus-in-brain-derived-neurotrophic-factor-gene-for-chronic-postsurgical-pain
#18
Yuanyuan Tian, Xiaodong Liu, Mingzhong Jia, Hui Yu, Peter Lichtner, Yujian Shi, Zhaoyu Meng, Shanglong Kou, Idy H T Ho, Bo Jia, Benny C P Cheng, Carmen K M Lam, Sharon Tsang, Sunny H Wong, Jun Yu, Christopher H K Cheng, Tony Gin, William K K Wu, Zheyu Chen, Matthew T V Chan
BACKGROUND: The purpose of this study was to evaluate the association between single-nucleotide polymorphisms and chronic postsurgical pain. METHODS: Using GoldenGate genotyping assays, we genotyped 638 polymorphisms within 54 pain-related genes in 1,152 surgical patients who were enrolled in our Persistent Pain after Surgery Study. Patients were contacted by phone to determine whether they had chronic postsurgical pain at 12 months. Polymorphisms identified were validated in a matched cohort of 103 patients with chronic postsurgical pain and 103 patients who were pain free...
November 9, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29114418/stop-being-so-sensitive-an-exceptionally-rare-report-of-ustekinumab-induced-sub-acute-hypersensitivity-pneumonitis
#19
Azka Ali, Jason Chertoff, Christopher Harden, Dara Wakefield, James Wynne
Hypersensitivity pneumonitis (HSP) is a rare syndrome characterised by granulomatous inflammatory lung disease due to repeated sensitisation from a specific antigen. We present the case of a 61-year old male veteran with a history of nodular eczema who presented with 2 weeks of progressive dyspnoea on exertion and pleuritic chest pain. The patient was started on ustekinumab 5 weeks prior to presentation. Initial workup revealed ground-glass opacities on computed tomography (CT) scan of the chest. Cardiac workup was unrevealing with a normal myocardial perfusion stress test...
October 2017: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/29105908/the-research-gap-in-chronic-paediatric-pain-a-systematic-review-of-randomised-controlled-trials
#20
REVIEW
R Boulkedid, A Y Abdou, E Desselas, M Manégat, T G de Leeuw, J Avez-Couturier, S Dugue, C Mareau, B Charron, C Alberti, F Kaguelidou
BACKGROUND AND OBJECTIVE: Chronic pain is associated with significant functional and social impairment. The objective of this review was to assess the characteristics and quality of randomized controlled trials (RCTs) evaluating pain management interventions in children and adolescents with chronic pain. METHODS: We performed a systematic search of PubMed, Embase and the Cochrane Library up to July 2017. We included RCTs that involved children and adolescents (3 months-18 years) and evaluated the use of pharmacological or non-pharmacological intervention(s) in the context of pain persisting or re-occurring for more than 3 months...
November 5, 2017: European Journal of Pain: EJP
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