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Ibd surveillance

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https://www.readbyqxmd.com/read/28631086/nearly-a-third-of-high-grade-dysplasia-and-colorectal-cancer-is-undetected-in-patients-with-inflammatory-bowel-disease
#1
Swathi Eluri, Alyssa M Parian, Berkeley N Limketkai, Christina Y Ha, Steven R Brant, Sharon Dudley-Brown, Jonathan E Efron, Sandy G Fang, Susan L Gearhart, Michael R Marohn, Stephen J Meltzer, Safar Bashar, Brindusa Truta, Elizabeth A Montgomery, Mark G Lazarev
BACKGROUND: It is unclear whether intensive surveillance protocols have resulted in a decreased incidence of colorectal cancer (CRC) in inflammatory bowel disease (IBD). AIMS: To determine the prevalence and characteristics of IBD associated high-grade dysplasia (HGD) or CRC that was undetected on prior colonoscopy. METHODS: This is a single-center, retrospective study from 1994 to 2013. All participants had a confirmed IBD diagnosis and underwent a colectomy with either HGD or CRC found in the colectomy specimen...
June 19, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28566881/inflammatory-bowel-disease-in-liver-transplanted-patients
#2
REVIEW
Tajana Filipec Kanizaj, Maja Mijic
Most common hepatobiliary manifestation of inflammatory bowel disease (IBD) are primary sclerosing cholangitis (PSC) and autoimmune hepatitis, ranking them as the main cause of liver transplantation (LT) in IBD setting. Course of pre-existing IBD after LT differs depending on many transplant related factors. Potential risk factors related to IBD deterioration after LT are tacrolimus-based immunosuppressive regimens, active IBD and cessation of 5-aminosalicylates at the time of LT. About 30% patients experience improvement of IBD after LT, while approximately the same percentage of patients worsens...
May 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28548906/beyond-the-bowel-extraintestinal-manifestations-of-inflammatory-bowel-disease
#3
Jeffrey D Olpin, Brett P Sjoberg, Sarah E Stilwill, Leif E Jensen, Maryam Rezvani, Akram M Shaaban
Inflammatory bowel disease (IBD) is a chronic, relapsing immune-mediated inflammation of the gastrointestinal tract. IBD includes two major disease entities: Crohn disease and ulcerative colitis. Imaging plays an important role in the diagnosis and surveillance of these complex disorders. Computed tomographic and magnetic resonance enterographic techniques have been refined in recent years to provide a superb means of evaluating the gastrointestinal tract for suspected IBD. Although the intestinal imaging manifestations of IBD have been extensively discussed in the radiology literature, extraintestinal imaging manifestations of IBD have received less attention...
May 26, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28511617/secondary-procedures-following-iliac-branch-device-treatment-of-aneurysms-involving-the-iliac-bifurcation-the-pelvis-registry
#4
Piergiorgio Cao, Konstantinos P Donas, Ciro Ferrer, Mirjam Inchingolo, Gianbattista Parlani, Georgios A Pitoulias, Carlo Pratesi, Giovanni Pratesi, Giovanni Torsello, Fabio Verzini
PURPOSE: To evaluate the incidence and reasons for secondary procedures in patients treated with iliac branch devices (IBDs) for isolated iliac aneurysm or aortoiliac aneurysms involving the iliac bifurcation. METHODS: Between January 2005 and December 2015, 575 surgical-high-risk patients (mean age 72.0±8.4 years; 558 men) with isolated iliac aneurysms (n=79) or aortoiliac aneurysms involving the iliac bifurcation (n=496) were treated with placement of 650 ZBIS or Gore IBDs (75 bilateral) in 6 European centers...
June 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28475382/dysplasia-and-colorectal-cancer-surveillance-in-inflammatory-bowel-disease
#5
Samba Siva Reddy Pulusu, Ian C Lawrance
Inflammatory bowel disease (IBD) patients are at an increased risk of developing colorectal cancer (CRC), a devastating complication of which intestinal dysplasia is the precursor. Considerable progress has been made to determine CRC risk in IBD, identification & management of dysplasia and preventative methods. Traditionally, surveillance colonoscopies with random colonic biopsies was used. However recent data suggests that chromoendoscopy is a better method of surveillance. Using 5-aminosalicylic acid agents primarily for chemoprevention is an ongoing debate however, when prescribed along with other strategies to control inflammation, their use is considered of benefit...
May 16, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28379306/anal-neoplasia-in-inflammatory-bowel-disease-classification-proposal-epidemiology-carcinogenesis-and-risk-management-perspectives
#6
Andrew Wisniewski, Jean-Francois Fléjou, Laurent Siproudhis, Laurent Abramowitz, Magali Svrcek, Laurent Beaugerie
Patients with inflammatory bowel disease [IBD] may develop, similarly to individuals from general population, rare cases of human papilloma virus [HPV]-related anal canal squamous cell carcinoma [SCC] and intra-epithelial precursor lesions, as well as very rare cases of anal canal adenocarcinoma. Patients with chronic perianal Crohn's disease [CD] are at substantial risk of developing SCC or adenocarcinoma from the fistula-lining epithelium, as well as SCC or adenocarcinoma arising from chronic anorectal ulcerations or strictures...
March 30, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28376583/inflammatory-bowel-disease-and-primary-sclerosing-cholangitis-a-review-of-the-phenotype-and-associated-specific-features
#7
REVIEW
Carolina Palmela, Farhad Peerani, Daniel Castaneda, Joana Torres, Steven H Itzkowitz
Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic disease that is associated with inflammatory bowel disease (IBD) in approximately 70% of cases. Although the pathogenesis is still unknown for both diseases, there is increasing evidence to indicate that they share a common underlying predisposition. Herein, we review the epidemiology, diagnosis, disease pathogenesis, and specific clinical features of the PSC-IBD phenotype. Patients with PSC-IBD have a distinct IBD phenotype with an increased incidence of pancolitis, backwash ileitis, and rectal sparing...
April 6, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28369329/vedolizumab-induces-long-term-mucosal-healing-in-patients-with-crohn-s-disease-and-ulcerative-colitis
#8
Maja Noman, Marc Ferrante, Raf Bisschops, Gert De Hertogh, Karolien Van den Broeck, Karen Rans, Paul J Rutgeerts, Séverine Vermeire, Gert Van Assche
Introduction.: Vedolizumab has proven efficacy in IBD, but long term mucosal healing in Crohn's disease (CD), as well as the incidence of colorectal neoplasia in IBD, among patients treated with vedolizumab have not been studied. We aimed to document mucosal healing and to explore the risk of colorectal neoplasia with vedolizumab maintenance therapy. Methods.: Surveillance colonoscopy was prospectively scheduled for patients with longstanding UC or CD at a tertiary referral center in the open label extension phase (vedolizumab 300 mg IV q 4 wks) of the Gemini studies (GEMINI LTS, study number NCT00790933)...
March 24, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28333258/immunoglobulin-and-infliximab-concentrations-in-dichorionic-twins-exposed-to-infliximab-in-utero
#9
Thea Vestergaard, Heidi Kammerlander, Birgitte Brock, Mette Julsgaard
No abstract text is available yet for this article.
March 10, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28333202/risk-of-rectal-neoplasia-after-colectomy-and-ileorectal-anastomosis-for-ulcerative-colitis
#10
Mathieu Uzzan, Julien Kirchgesner, Nadia Oubaya, Aurélien Amiot, Jean-Marc Gornet, Philippe Seksik, Stéphane Nancey, Eddy Cotte, Matthieu Allez, Gilles Boschetti, David Laharie, Nicola de Angelis, Maria Nachury, Anne-Laure Pelletier, Vered Abitbol, Mathurin Fumery, Antoine Brouquet, Anthony Buisson, Romain Altwegg, Jacques Cosnes, Yves Panis, Xavier Treton
Introduction-: Colectomy can be required in the management of ulcerative colitis (UC). While ileal pouch anal-anastomosis (IPAA) is the recommended reconstruction technique, ileorectal anastomosis (IRA) is still performed and might present some advantages. However, the risk of rectal neoplasia might limit its indication. The aims of our study were to determine the incidence of rectal neoplasias following IRA for UC and to identify risk factors associated with rectal carcinomas. Methods-: We performed a multicenter retrospective study including patients who underwent IRA for UC from 1960 to 2014 in 13 centers...
February 21, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28193515/infliximab-is-not-associated-with-increased-risk-of-malignancy-or-hemophagocytic-lymphohistiocytosis-in-pediatric-patients-with-inflammatory-bowel-disease
#11
Jeffrey S Hyams, Marla C Dubinsky, Robert N Baldassano, Richard B Colletti, Salvatore Cucchiara, Johanna Escher, William Faubion, John Fell, Benjamin D Gold, Anne Griffiths, Sibylle Koletzko, Subra Kugathasan, James Markowitz, Frank M Ruemmele, Gigi Veereman, Harland Winter, Nicholas Masel, Chu Ri Shin, Kezhen L Tang, Meena Thayu
BACKGROUND AND AIMS: Immunosuppressive therapy for inflammatory bowel disease (IBD) in pediatric patients is thought to increase the risk of malignancy and lymphoproliferative disorders, including hemophagocytic lymphohistiocytosis (HLH). We compared unadjusted incidence rates of malignancy and HLH in pediatric patients with IBD exposed to infliximab (IFX) with patients not exposed to biologics and calculated standardized incidence ratios (SIRs). METHODS: We collected and analyzed data from 5766 participants in a prospective study of long-term outcomes of pediatric patients with IBD (NCT00606346), from May 31, 2007 through June 30, 2016...
June 2017: Gastroenterology
https://www.readbyqxmd.com/read/28187737/evaluation-of-a-web-based-registry-of-inherited-bleeding-disorders-a-descriptive-study-of-the-brazilian-experience-with-hemovidaweb-coagulopatias
#12
Suely Meireles Rezende, Silvia Helena Lacerda Rodrigues, Kelly Neves Pinheiro Brito, Diego Lima Quintino da Silva, Marcos Lázaro Santo, Bárbara de Jesus Simões, Guilherme Genovez, Helder Teixeira Melo, João Paulo Baccara Araújo, Danila Augusta Accioly Varella Barca
BACKGROUND: Inherited bleeding disorders (IBD) consist of a group of rare heterogeneous diseases, which require treatment for life. Management of these disorders is complex and costly. Therefore, good quality data of the affected population is crucial to guide policy planning. The aim of this manuscript is to describe the impact of a national, web-based registry - the Hemovidaweb Coagulopatias (HWC) - in the management of the IBD in Brazil. METHODS: The system was developed in PHP 5...
February 10, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28174420/clonal-evolution-of-colorectal-cancer-in-ibd
#13
REVIEW
Chang-Ho R Choi, Ibrahim Al Bakir, Ailsa L Hart, Trevor A Graham
Optimizing the management of colorectal cancer (CRC) risk in IBD requires a fundamental understanding of the evolutionary process underpinning tumorigenesis. In IBD, clonal evolution begins long before the development of overt neoplasia, and is probably accelerated by the repeated cycles of epithelial wounding and repair that are characteristic of the condition. Here, we review the biological drivers of mutant clone selection in IBD with particular reference to the unique histological architecture of the intestinal epithelium coupled with the inflammatory microenvironment in IBD, and the unique mutation patterns seen in IBD-driven neoplasia when compared with sporadic adenomas and CRC...
April 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28172862/p220-current-practices-in-ileal-pouch-surveillance-for-ulcerative-colitis-patients-in-three-london-ibd-referral-centres
#14
M Kabir, S Morgan, M A Samaan, K Forsyth, J P Segal, S Elkady, A P Z Arenaza, K Kok, E Seward, R Vega, S Di Caro, E Westcott, S Mehta, F Rahman, S McCartney, S L Bloom, M Northover, A Darakhshan, A Williams, S Anderson, J Sanderson, A Hart, P M Irving
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28147349/leukocyte-anti-trafficking-strategies-current-status-and-future-directions
#15
REVIEW
Bruce E Sands
BACKGROUND: In inflammatory bowel diseases (IBD), a pivotal step in the initiation and perpetuation of mucosal inflammation entails the recruitment of inflammatory leukocytes to the gut. Understanding the carefully coordinated series of molecular events that culminate in the recruitment of leukocytes to the gut has resulted in novel interventions with new capabilities in treating both Crohn's disease and ulcerative colitis. Key Messages: Natalizumab, an anti-α4 integrin antibody, was the first agent to demonstrate the efficacy of this approach for the induction and maintenance of response and remission in Crohn's disease...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28126349/full-spectrum-endoscopy-improves-surveillance-for-dysplasia-in-patients-with-inflammatory-bowel-diseases
#16
Rupert W Leong, Marie Ooi, Crispin Corte, Yunki Yau, Melissa Kermeen, Peter H Katelaris, Charles McDonald, Meng Ngu
BACKGROUND & AIMS: Inflammatory bowel diseases (IBDs) increase the risk of colorectal cancer. Surveillance colonoscopy with chromoendoscopy is recommended, but conventional forward-viewing colonoscopy (FVC) detects dysplasia with low levels of sensitivity. Full-spectrum endoscopy (FUSE) incorporates 2 additional lateral cameras to the forward camera of the colonoscope, allowing endoscopists to view behind folds and in blind spots, which might increase dysplasia detection. We compared FUSE vs FVC in the detection of dysplasia in patients with IBDs...
May 2017: Gastroenterology
https://www.readbyqxmd.com/read/28115492/are-random-biopsies-still-useful-for-the-detection-of-neoplasia-in-patients-with-ibd-undergoing-surveillance-colonoscopy-with-chromoendoscopy
#17
Driffa Moussata, Matthieu Allez, Dominique Cazals-Hatem, Xavier Treton, David Laharie, Jean-Marie Reimund, Philippe Bertheau, Arnaud Bourreille, Anne Lavergne-Slove, Hedia Brixi, Julien Branche, Jean-Marc Gornet, Carmen Stefanescu, Jacques Moreau, Philippe Marteau, Anne-Laure Pelletier, Franck Carbonnel, Philippe Seksik, Marion Simon, Jean-François Fléjou, Jean-Fréderic Colombel, Anne-Laure Charlois, Xavier Roblin, Stéphane Nancey, Yoram Bouhnik, Françoise Berger, Bernard Flourié
BACKGROUND: Colonoscopy with pan-chromoendoscopy (CE) is superior to standard colonoscopy in detecting neoplasia in patients with IBD. Performing random biopsies in unsuspicious mucosa after CE remains controversial. METHODS: Consecutive patients with IBD who underwent surveillance colonoscopy using CE were prospectively included. The standardised procedure used CE, performed targeted biopsies or endoscopic resection on suspicious lesions and then quadrant random biopsies every 10 cm...
January 23, 2017: Gut
https://www.readbyqxmd.com/read/28081040/azathioprine-therapy-in-a-pediatric-tpmt-deficient-patient-still-an-option
#18
S A W van Moorsel, N Bevers, M Meurs, L K van Rossum, P M Hooymans, D R Wong
We describe the case of a pediatric patient on azathioprine therapy with previously undiagnosed homozygote thiopurine S-methyltransferase (TPMT) deficiency, resulting in myelotoxic thiopurine metabolite levels. The patient was successfully treated with a very low azathioprine dose of 50 mg once a week (4% of standard dose), guided by frequent thiopurine metabolite measurement and a close clinical surveillance. We demonstrate that azathioprine therapy still might be an effective and safe therapeutic option in pediatric thiopurine S-methyltransferase-deficient IBD patients...
February 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28070659/diagnosis-treatment-and-consequences-of-anastomotic-leakage-in-colorectal-surgery
#19
Bodil Gessler, Olle Eriksson, Eva Angenete
PURPOSE: The aim of this study was to explore the choice of modality for diagnosis, treatments, and consequences of anastomotic leakage. METHODS: This is a retrospective study of consecutive patients who underwent surgery that included a colorectal anastomosis due to colorectal cancer, diverticulitis, inflammatory bowel disease (IBD), or benign polyps. RESULTS: A total of 600 patients were included during 2010-2012, and 60 (10%) had an anastomotic leakage...
April 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28042386/endoscopic-evaluation-in-diagnosis-and-management-of-inflammatory-bowel-disease
#20
REVIEW
Carthage P Moran, Barra Neary, Glen A Doherty
Endoscopy is a keystone in the management of patients with inflammatory bowel disease (IBD). It is the fundamental diagnostic tool for IBD, and can help discern between ulcerative colitis and Crohn's disease. Endoscopic assessment provides an objective end point in clinical trials, and identifies patients in clinical practice who may benefit from treatment escalation and may assist risk stratification in patients seeking to discontinue therapy. Recent advances in endoscopic assessment of patients with IBD include video capsule endoscopy, and chromoendoscopy...
December 16, 2016: World Journal of Gastrointestinal Endoscopy
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