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Ibd surveillance

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https://www.readbyqxmd.com/read/29351318/invasive-bacterial-disease-trends-and-characterization-of-group-b-streptococcal-isolates-among-young-infants-in-southern-mozambique-2001-2015
#1
Betuel Sigaúque, Miwako Kobayashi, Delfino Vubil, Ariel Nhacolo, Alberto Chaúque, Benild Moaine, Sérgio Massora, Inácio Mandomando, Tacilta Nhampossa, Quique Bassat, Fabiana Pimenta, Clara Menéndez, Maria da Gloria Carvalho, Eusebio Macete, Stephanie J Schrag
BACKGROUND: Maternal group B streptococcal (GBS) vaccines under development hold promise to prevent GBS disease in young infants. Sub-Saharan Africa has the highest estimated disease burden, although data on incidence and circulating strains are limited. We described invasive bacterial disease (IBD) trends among infants <90 days in rural Mozambique during 2001-2015, with a focus on GBS epidemiology and strain characteristics. METHODS: Community-level birth and mortality data were obtained from Manhiça's demographic surveillance system...
2018: PloS One
https://www.readbyqxmd.com/read/29342165/increased-colon-cancer-risk-after-severe-salmonella-infection
#2
Lapo Mughini-Gras, Michael Schaapveld, Jolanda Kramers, Sofie Mooij, E Andra Neefjes-Borst, Wilfrid van Pelt, Jacques Neefjes
BACKGROUND: Colon cancer constitutes one of the most frequent malignancies. Previous studies showed that Salmonella manipulates host cell signaling pathways and that Salmonella Typhimurium infection facilitates colon cancer development in genetically predisposed mice. This epidemiological study examined whether severe Salmonella infection, usually acquired from contaminated food, is associated with increased colon cancer risk in humans. METHODS AND FINDINGS: We performed a nationwide registry-based study to assess colon cancer risk after diagnosed Salmonella infection...
2018: PloS One
https://www.readbyqxmd.com/read/29313389/multi-target-stool-dna-test-in-the-surveillance-of-inflammatory-bowel-disease-a-cross-sectional-cohort-study
#3
Pasquale Klepp, John B Kisiel, Milada Cvancarova Småstuen, Arne Røseth, Solveig N Andersen, Morten H Vatn, David A Ahlquist, Bjørn A Moum, Stephan Brackmann
BACKGROUND AND AIM: Colonoscopic surveillance is recommended in patients with longstanding inflammatory bowel disease (IBD) as they are at increased risk of colorectal cancer (CRC). Non-invasive surveillance may improve compliance and access. Multi-target stool DNA (MT-sDNA) has been validated for screening of sporadic CRC but has not been assessed in IBD. Our aim was to assess the performance of a MT-sDNA test in a real-life surveillance setting of patients with longstanding IBD. MATERIAL AND METHODS: A total of 192 IBD patients enrolled from two prospective cohorts submitted an EDTA buffered stool sample and underwent chromo- or white light colonoscopy...
January 9, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29261447/serologic-surveillance-of-wild-and-pen-reared-ring-necked-pheasants-phasianus-colchicus-as-a-method-of-understanding-disease-reservoirs
#4
Ian A Dwight, Peter S Coates, Simone T Stoute, C Gabriel Senties-Cue, Radhika V Gharpure, Maurice E Pitesky
We investigated exposure to infectious diseases in wild ( n=33) and pen-reared ( n=12) Ring-necked Pheasants ( Phasianus colchicus) in the Central Valley of California during 2014 and 2015. Serologic tests were positive for antibodies against hemorrhagic enteritis (HE), infectious bursal disease (IBD), and Newcastle disease (ND) viruses in both wild and pen-reared pheasants.
December 20, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29260278/role-of-contrast-enhanced-ultrasound-in-evaluation-of-the-bowel
#5
Alexandra Medellin, Christina Merrill, Stephanie R Wilson
Contrast-enhanced ultrasound (CEUS) of the gastrointestinal tract provides vascular information helpful for characterizing masses and other pathologies in and around the bowel, similar to contrast applications in other solid organs. However, the use of microbubble contrast agents for the bowel provides additional unique contributions as it gives both subjective and objective information about mural and mesenteric blood flow, invaluable for the determination of disease activity in those many patients affected by inflammatory bowel disease (IBD)...
December 19, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29242771/sentinels-at-the-frontline-the-role-of-intraepithelial-lymphocytes-in-inflammatory-bowel-disease
#6
Madeleine D Hu, Karen L Edelblum
Purpose of review: Intestinal mucosal immunity is tightly regulated to ensure effective host defense against invasive microorganisms while limiting the potential for aberrant damage. In inflammatory bowel disease (IBD), an imbalance between effector and regulatory T cell populations results in an uncontrolled inflammatory response to commensal bacteria. Intraepithelial lymphocytes (IEL) are perfectly positioned within the intestinal epithelium to provide the first line of mucosal defense against luminal microbes or rapidly respond to epithelial injury...
December 2017: Current Pharmacology Reports
https://www.readbyqxmd.com/read/29215479/major-abdominal-and-perianal-surgery-in-crohn-s-disease-long-term-follow-up-of-australian-patients-with-crohn-s-disease
#7
MULTICENTER STUDY
James W T Toh, Nelson Wang, Christopher J Young, Matthew J F X Rickard, Anil Keshava, Peter Stewart, Viraj Kariyawasam, Rupert Leong
BACKGROUND: Most patients with Crohn's disease still require surgery despite significant advances in medical therapy, surveillance, and management strategies. OBJECTIVE: The purpose of this study was to assess surgical strategies and outcomes in Crohn's disease, including surgical recurrence and emergency surgery. DESIGN: This was a multicenter, retrospective review of a prospectively collected database. SETTINGS: A specialist-referred cohort of patients with Crohn's disease between 1970 and 2009 was studied...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29170864/risk-of-malignancy-in-a-nationwide-cohort-of-elderly-inflammatory-bowel-disease-patients
#8
Nabeel Khan, Carlos Vallarino, Trevor Lissoos, Umar Darr, Michelle Luo
BACKGROUND: Management of elderly inflammatory bowel disease (IBD) patients (≥ 65 years of age) is complicated due to many factors, including a higher risk of cancer, which may impact therapeutic decisions. OBJECTIVE: The aim of this study was to determine the risk of cancer among elderly IBD patients compared with younger IBD patients. Additionally, the absolute risk of malignancy and factors contributing to it were evaluated, and therapeutic patterns among the elderly were assessed...
November 23, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29134964/a-randomized-trial-comparing-high-definition-colonoscopy-alone-with-high-definition-dye-spraying-and-electronic-virtual-chromoendoscopy-for-detection-of-colonic-neoplastic-lesions-during-ibd-surveillance-colonoscopy
#9
Marietta Iacucci, Gilaad G Kaplan, Remo Panaccione, Oluseyi Akinola, Brendan Cord Lethebe, Mark Lowerison, Yvette Leung, Kerri L Novak, Cynthia H Seow, Stefan Urbanski, Parham Minoo, Xianyong Gui, Subrata Ghosh
OBJECTIVES: Dye spraying chromoendoscopy (DCE) is recommended for the detection of colonic neoplastic lesions in inflammatory bowel disease (IBD). The majority of neoplastic lesions are visible endoscopically and therefore targeted biopsies are appropriate for surveillance colonoscopy. To compare three different techniques for surveillance colonoscopy to detect colonic neoplastic lesions in IBD patients: high definition (HD), (DCE), or virtual chromoendoscopy (VCE) using iSCAN image enhanced colonoscopy...
November 14, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29077712/quantifying-connectivity-between-local-plasmodium-falciparum-malaria-parasite-populations-using-identity-by-descent
#10
Aimee R Taylor, Stephen F Schaffner, Gustavo C Cerqueira, Standwell C Nkhoma, Timothy J C Anderson, Kanlaya Sriprawat, Aung Pyae Phyo, François Nosten, Daniel E Neafsey, Caroline O Buckee
With the rapidly increasing abundance and accessibility of genomic data, there is a growing interest in using population genetic approaches to characterize fine-scale dispersal of organisms, providing insight into biological processes across a broad range of fields including ecology, evolution and epidemiology. For sexually recombining haploid organisms such as the human malaria parasite P. falciparum, however, there have been no systematic assessments of the type of data and methods required to resolve fine scale connectivity...
October 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29072418/colitis-associated-colorectal-cancer-in-patients-with-inflammatory-bowel-disease
#11
Se-Jin Baek, Seon-Hahn Kim
Colitis-associated colorectal cancer (CACRC) is a major concern in patients with long-standing inflammatory bowel disease (IBD). CACRC can develop under the influence of several risk factors including longer duration and disease extent and shows clinical and molecular features different from those of sporadic CRC. Several academic societies have recommended surveillance guidelines for CACRC that develops in IBD patients. Patients are stratified according to risk for CRC and differentiated by surveillance colonoscopy and management...
December 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/29027468/serrated-polyposis-syndrome-associated-with-long-standing-inflammatory-bowel-disease
#12
Jesús Castro, Miriam Cuatrecasas, Francesc Balaguer, Elena Ricart, María Pellisé
Inflammatory bowel disease (IBD) patients are at an increased risk of developing colorectal cancer (CRC), which is thought to develop via the adenoma-carcinoma pathway. Since the discovery of the serrated carcinogenesis pathway and serrated polyposis syndrome (SPS), the incidence of carcinomas arising from serrated lesions in IBD patients has increased. We report three cases of long-standing IBD patients with associated serrated polyposis syndrome. At present, the pathophysiology of serrated lesions in IBD patients is not fully understood and there is a lack of strong evidence to confirm whether the manifestation of both conditions represents an increased risk of developing cancer...
November 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29023984/partial-to-complete-abrogation-of-the-sub-epithelial-macrophage-barrier-against-the-gut-microbiota-in-patients-with-ulcerative-colitis-and-crohn-s-colitis
#13
Carlos A Rubio, Cord Langner, Peter T Schmidt
AIMS: The integrity of the subepithelial band of indigenous macrophages in the lamina-propria (SLP-MΦ) is crucial in deterring the commensal gut-microbiota from host-assailment. The breakdown of the SLP-MΦ barrier results in microbiota inflow and improper immune responses; this might lead to IBD. During inflammation, the SLP-MΦ-barrier is reinforced by inflammation-elicited MΦ (IEMΦ, derived from blood-circulating monocytes). The aim was to explore the characteristics of the SLP-MΦ band in a cohort of biopsies without inflammation, in patients with ulcerative colitis-in remission (UCre), and in patients with right-sided Crohn's colitis (RCC)...
October 11, 2017: Histopathology
https://www.readbyqxmd.com/read/29019424/endoscopy-for-patients-affected-by-inflammatory-bowel-disease-bowel-preparation-and-sedation
#14
Cristina Bezzio, Paolo Andreozzi, Valentina Casini, Gianpiero Manes, Simone Saibeni
Endoscopy has a key role in the management of inflammatory bowel disease (IBD). It is helpful in the diagnosis, in case of relapse, refractoriness, before therapeutic changes, after surgery as well as in the assessment of mucosal healing and in the surveillance of colo-rectal cancer. IBD patients are intended to undergo several times the examination during their lifespan. Bowel preparation and sedation highly contribute to high-quality colonoscopy. Areas covered: Few studies addressed preparation and sedation in the field of IBD...
October 17, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29017290/role-of-advanced-endoscopic-imaging-techniques-in-the-management-of-inflammatory-bowel-disease
#15
REVIEW
Eun Soo Kim
Endoscopy plays a crucial role in the management of inflammatory bowel disease (IBD) in terms of diagnosis, monitoring of mucosal status, and surveillance of colitis-associated neoplasia. Mucosal healing evaluated by endoscopy has been recognized as the target of treatment in the era of powerful biologics therapy. The optimal modality for identifying dysplasia in IBD has yet to be well defined. Increasing progress has recently been made in endoscopic technologies to more accurately assess mucosal inflammation and more effectively detect dysplasia...
September 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28994306/pharmacological-treatments-and-infectious-diseases-in-pediatric-inflammatory-bowel-disease
#16
Valeria Dipasquale, Claudio Romano
The incidence of pediatric inflammatory bowel disease (IBD) is rising, as is the employment of immunosuppressive and biological drugs. Most patients with IBD receive immunosuppressive therapies during the course of the disease. These molecules are a double-edged sword; while they can help control disease activity, they also increase the risk of infections. Therefore, it is important that pediatricians involved in primary care, pediatric gastroenterologists, and infectious disease physicians have a thorough knowledge of the infections that can affect patients with IBD...
October 10, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28991855/cancer-risk-in-2621-chinese-patients-with-inflammatory-bowel-disease-a-population-based-cohort-study
#17
Jacqueline So, Whitney Tang, Wai Keung Leung, Michael Li, Fu Hang Lo, Marc T L Wong, Alex Shun Fung Sze, Chi Man Leung, Steven Woon Choy Tsang, Edwin Hok Shing Shan, Kam Hon Chan, Belsy C Y Lam, Aric J Hui, Wai Hung Chow, Tsz Yiu Lam, Vernon Lam, Tsz Wai Lee, Harris Ho Him Lo, Ching Man Tang, Cheuk Lau Wong, Justin C Y Wu, Francis K L Chan, Joseph J Y Sung, Marcus Harbord, Siew C Ng
BACKGROUND: Studies on cancer risk in inflammatory bowel disease (IBD) have yielded inconsistent results. We conducted a population-based study to determine the risk of cancer in patients with Crohn's disease (CD) and ulcerative colitis (UC). METHODS: Using a territory-wide IBD registry in Hong Kong, we identified 2621 patients with IBD and no history of cancer from 1990 to 2016. We followed them from diagnosis until either September 2016, cancer development, proctocolectomy, or death...
November 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28983504/perspectives-on-endoscopic-surveillance-of-dysplasia-in-inflammatory-bowel-disease-a-survey-of-academic-gastroenterologists
#18
Zane R Gallinger, Amir Rumman, Sanjay K Murthy, Geoffrey C Nguyen
BACKGROUND AND STUDY AIMS:  Dye-based chromoendoscopy (DBC) is the preferred method for endoscopic dysplasia surveillance in patients with inflammatory bowel disease (IBD). We sought to examine the uptake of, and perception toward DBC among academic gastroenterologists. METHODS:  We conducted an online survey of academic members of the Canadian Association of Gastroenterology to assess their current dysplasia surveillance practice, uptake of DBC, and perceived barriers to adoption of DBC...
October 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28981976/inflammatory-bowel-disease-in-chronic-granulomatous-disease-an-emerging-problem-over-a-twenty-years-experience
#19
Giulia Angelino, Paola De Angelis, Simona Faraci, Francesca Rea, Erminia Francesca Romeo, Filippo Torroni, Renato Tambucci, Alessia Claps, Paola Francalanci, Maria Chiriaco, Gigliola Di Matteo, Caterina Cancrini, Paolo Palma, Patrizia D'Argenio, Luigi Dall'Oglio, Paolo Rossi, Andrea Finocchi
BACKGROUND: Chronic granulomatous disease (CGD) is a primary immunodeficiency of phagocytes, characterized by life-threatening infections and hyperinflammation. Due to survival improvement, inflammatory bowel disease (IBD) is becoming increasingly relevant. Here, we report our 20 year experience. METHODS: We retrospectively analyzed clinic, endoscopic, and histologic features, as well as the management of CGD-IBD patients referred to the Bambino Gesù Children's Hospital in Rome, Italy...
December 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28965228/chromoendoscopy-narrow-band-imaging-or-white-light-endoscopy-for-neoplasia-detection-in-inflammatory-bowel-diseases
#20
REVIEW
Ofir Har-Noy, Lior Katz, Tomer Avni, Robert Battat, Talat Bessissow, Diana E Yung, Tal Engel, Anastasios Koulaouzidis, Rami Eliakim, Shomron Ben-Horin, Uri Kopylov
BACKGROUND: Studies have confirmed an increased risk of colorectal cancer in patients with ulcerative colitis; hence, surveillance is recommended. Optional modalities include white light endoscopy (WLE) or dye-spray chromoendoscopy. However, narrow-band imaging (NBI) is still not considered comparable to chromoendoscopy. AIM: The aim of this study was to compare the diagnostic yield (DY) of WLE, chromoendoscopy, NBI for detection of neoplasia in patients with inflammatory bowel disease (IBD) by performing a meta-analysis of the existing literature...
November 2017: Digestive Diseases and Sciences
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