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heat ablation

Nathan McDannold, Margaret Livingstone, Can Barış Top, Jonathan Sutton, Nick Todd, Natalia Vykhodtseva
This study investigated thermal ablation and skull-induced heating with a 230 kHz transcranial MRI-guided focused ultrasound (TcMRgFUS) system in nonhuman primates. We evaluated real-time acoustic feedback and aimed to understand whether cavitation contributed to the heating and the lesion formation. In four macaques, we sonicated thalamic targets at acoustic powers of 34-560 W (896-7590 J). Tissue effects evaluated with MRI and histology were compared to MRI-based temperature and thermal dose measurements, acoustic emissions recorded during the experiments, and acoustic and thermal simulations...
October 14, 2016: Physics in Medicine and Biology
Atsushi Tabuchi, Hisao Masaki, Yasuhiro Yunoki, Yoshiko Watanabe, Hiroshi Furukawa, Takahiko Yamasawa, Hiroki Takiuchi, Takeshi Honda, Noriaki Kuwada, Kenji Kojima, Kazuo Tanemoto
We performed a comparative study of surgical outcomes and venous functions between endovenous laser ablation with a 980-nm diode laser (EV group) and thigh stripping (ST group). There were no severe complications and initial success rates were 100% in both groups. In the EV group, preoperative symptoms improved in 94.3% of cases, the venous occlusion rate was 98%, and endovenous heat induced thrombosis had occurred in 11.9% (Class 3: 0.7%) at 12 months after the operation. Although comparative study of postoperative venous function by air plethysmography showed significant improvement in both groups, there was less recovery of postoperative venous function in the EV than in the ST group...
2016: Annals of Vascular Diseases
Sheetal Parida, Chiranjit Maiti, Y Rajesh, Kaushik K Dey, Ipsita Pal, Aditya Parekh, Rusha Patra, Dibakar Dhara, Pranab Kumar Dutta, Mahitosh Mandal
BACKGROUND: Gold nanorods, by virtue of surface plasmon resonance, convert incident light energy (NIR) into heat energy which induces hyperthermia. We designed unique, multifunctional, gold nanorod embedded block copolymer micelle loaded with GW627368X for targeted drug delivery and photothermal therapy. METHODS: Glutathione responsive diblock co-polymer was synthesized by RAFT process forming self-assembled micelle on gold nanorods prepared by seed mediated method and GW627368X was loaded on to the reduction responsive gold nanorod embedded micelle...
October 6, 2016: Biochimica et Biophysica Acta
Bin Duan, Rong Wen, Yabo Fu, Kian-Jon Chua, Chee-Kong Chui
A challenging problem of radiofrequency ablation (RFA) in liver surgery is to accurately estimate the shapes and sizes of RFA lesions whose formation depends on intrinsic variations of the thermal-electrical properties of soft tissue. Large tumors, which can be as long as 10 cm or more, further complicate the problem. In this paper, a probabilistic bio-heating finite element (FE) model is proposed and developed to predict RFA lesions. Uncertainties of RFA lesions are caused by the probabilistic nature of five thermal-electrical liver properties: thermal conductivity, liver tissue density, specific heat, blood perfusion rate and electrical conductivity...
October 4, 2016: Medical Engineering & Physics
Natalie Lucchina, Dimitrios Tsetis, Anna Maria Ierardi, Francesca Giorlando, Edoardo Macchi, Elias Kehagias, Ejona Duka, Federico Fontana, Lorenzo Livraghi, Gianpaolo Carrafiello
Percutaneous radiofrequency ablation (RFA) can be as effective as surgical resection in terms of overall survival and recurrence-free survival rates in patients with small hepatocellular carcinoma (HCC). Effectiveness of RFA is adversely influenced by heat-sink effect. Other ablative therapies could be considered for larger tumors or for tumors located near the vessels. In this regard, recent improvements in microwave energy delivery systems seem to open interesting perspectives to percutaneous ablation, which could become the ablation technique of choice in the near future...
October 2016: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Marc Napoleone, Ania Z Kielar, Rebecca Hibbert, Sameh Saif, Benjamin Y M Kwan
PURPOSE: We aimed to evaluate patterns of local tumor progression (LTP) after radiofrequency ablation (RF ablation) of colorectal cancer liver metastases (CRCLM) and to highlight the percentage of LTP not attributable to lesion size or RF ablation procedure-related factors (heat sink or insufficient ablation margin). METHODS: CRCLM treated by RF ablation at a single tertiary care center from 2004-2012, with a minimum of six months of post-procedure follow-up, were included in this retrospective study...
October 3, 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
C Corbin, E R Heyworth, J Ferrari, G D D Hurst
Heritable microbes represent an important component of the biology, ecology and evolution of many plants, animals and fungi, acting as both parasites and partners. In this review, we examine how heritable symbiont-host interactions may alter host thermal tolerance, and how the dynamics of these interactions may more generally be altered by thermal environment. Obligate symbionts, those required by their host, are considered to represent a thermally sensitive weak point for their host, associated with accumulation of deleterious mutations...
October 5, 2016: Heredity
Vivian Huynh, Zachary J Sasiene, Phillip M Mach, Teresa D Golden, Guido F Verbeck
Laser ablation has been applied to redacted documents, where the text has been concealed by other ink. This technique strips the redacting ink revealing the text that was once redacted. Once removed, a nanomanipulation technique is used to extract the ink of the underlying text where mass spectrometry is then implemented to analyze its ink chemistry. In order to facilitate microscopy with direct analyte-probed nanoextraction coupled to nanospray ionization mass spectrometry (DAPNe-NSI-MS), laser ablation must be executed prior to ink extraction...
September 2016: Science & Justice: Journal of the Forensic Science Society
Xin Li, Yongmin Zhong, Julian Smith, Chengfan Gu
Prediction of tissue damage under thermal loads plays important role for thermal ablation planning. A new methodology is presented in this paper by combing non-Fourier bio-heat transfer, constitutive elastic mechanics as well as non-rigid motion of dynamics to predict and analyze thermal distribution, thermal-induced mechanical deformation and thermal-mechanical damage of soft tissues under thermal loads. Simulations and comparison analysis demonstrate that the proposed methodology based on the non-Fourier bio-heat transfer can account for the thermal-induced mechanical behaviors of soft tissues and predict tissue thermal damage more accurately than classical Fourier bio-heat transfer based model...
September 30, 2016: Bioengineered
Nick Frazier, Allison Payne, Joshua de Bever, Christopher Dillon, Apoorva Panda, Nithya Subrahmanyam, Hamidreza Ghandehari
Mild hyperthermia has been used in combination with polymer therapeutics to further increase delivery to solid tumors and enhance efficacy. An attractive method for generating heat is through non-invasive high intensity focused ultrasound (HIFU). HIFU is often used for ablative therapies and must be adapted to produce uniform mild hyperthermia in a solid tumor. In this work a magnetic resonance imaging guided HIFU (MRgHIFU) controlled feedback system was developed to produce a spatially uniform 43°C heating pattern in a subcutaneous mouse tumor...
November 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
Nirmala Jagadish, Sumit Agarwal, Namita Gupta, Rukhsar Fatima, Sonika Devi, Vikash Kumar, Vaishali Suri, Rajive Kumar, Vitusha Suri, Trilok Chand Sadasukhi, Anju Gupta, Abdul S Ansari, Nirmal Kumar Lohiya, Anil Suri
BACKGROUND: Breast cancer is one of the leading cause of cancer-related deaths in women worldwide and increasing rapidly in developing countries. In the present study, we investigated the potential role and association of HSP70-2 with breast cancer. METHODS: HSP70-2 expression was examined in 154 tumor and 103 adjacent non-cancerous tissue (ANCT) specimens and breast cancer cell lines (MCF7, BT-474, SK-BR-3 and MDA-MB-231) by RT-PCR, quantitative-PCR, immunohistochemistry, Western blotting, flow cytometry and indirect immunofluorescence...
2016: Journal of Experimental & Clinical Cancer Research: CR
Montree Chaichanyut, Supan Tungjitkusolmun
This research is concerned with microwave ablation analyses using a 2.45 GHz four-tine (4T) antenna for hepatic cancer tissue. In the study, three-dimensional finite-element models were utilized to examine the tissue temperature distributions during and after MW ablation. A preliminary study was first carried out with regard to the specific absorption rates along the 4T antenna insertion depths and the temperature distributions inside the solid and porous liver models with either 3 cm-in-diameter tumor or 5 cm-in-diameter tumor...
2016: Computational and Mathematical Methods in Medicine
Sneha S Kelkar, Eleanor McCabe-Lankford, Richard Albright, Phil Harrington, Nicole H Levi-Polyachenko
BACKGROUND AND OBJECTIVE: Photothermal therapy (PTT) has several applications in the areas of wound healing, pain management, bacterial infection control, and cancer treatment dependent on the temperature that is generated. PTT is often used exclusively with near infrared (NIR) light and most nanoparticles (NP) used for PTT are designed to absorb within one narrow range of wavelengths. We have developed a dual-wavelength photothermal therapy by capitalizing on the dual absorption of nanoparticles in the blue and NIR range...
September 16, 2016: Lasers in Surgery and Medicine
Vasanth S Murali, Ruhung Wang, Carole A Mikoryak, Paul Pantano, Rockford K Draper
Single-walled carbon nanotubes (SWNTs) are used in the near infrared (NIR)-mediated thermal ablation of tumor cells because they efficiently convert absorbed NIR light into heat. Despite the therapeutic potential of SWNTs, there have been no published studies that directly quantify how many SWNTs need be associated with a cell to achieve a desired efficiency of killing, or what is the most efficient subcellular location of SWNTs for killing cells. Herein we measured dose response curves for the efficiency of killing correlated to the measured amounts of folate-targeted SWNTs that were either on the surface or within the vacuolar compartment of normal rat kidney cells...
October 21, 2016: Nanotechnology
Haiming Cheng, Changqing Hong, Xinghong Zhang, Huafei Xue, Songhe Meng, Jiecai Han
The desire for lightweight nanoporous materials with high-performance thermal insulation and efficient anti-ablation resistance for energy conservation and thermal protection/insulation has greatly motivated research and development recently. The main challenge to synthesize such lightweight materials is how to balance the relationship of low thermal conductivity and flame retardancy. Herein, we propose a new concept of lightweight "rime-like" structured carbon-phenolic nanocomposites to solve this problem, where the 3D chopped network-structured carbon fiber (NCF) monoliths are incorporated with nanoporous phenolic aerogel to retain structural and functional integrity...
2016: Scientific Reports
Shushovan Chakrabortty, Sanjeev Kumar, Deepak Gupta, Sruthi Rudraraju
As many as 62% low back pain patients can have sacroiliac joint (SIJ) pain. There is limited (to poor) evidence in regards to long-term pain relief with therapeutic intra-articular injections and/or conventional (heat or pulsed) radiofrequency ablations (RFAs) for SIJ pain. We report our pain-clinic experience with peripheral nerve field stimulation (PNFS) for two patients of intractable SIJ pain. They had reported absence of long-term pain relief (pain relief >50% for at least 2 weeks postinjection and at least 3 months post-RFA) with SIJ injections and SIJ RFAs...
July 2016: Journal of Anaesthesiology, Clinical Pharmacology
Scott M Thompson, Matthew R Callstrom, Danielle E Jondal, Kim A Butters, Bruce E Knudsen, Jill L Anderson, Karen R Lien, Shari L Sutor, Ju-Seog Lee, Snorri S Thorgeirsson, Joseph P Grande, Lewis R Roberts, David A Woodrum
Thermal ablative therapies are important treatment options in the multidisciplinary care of patients with hepatocellular carcinoma (HCC), but lesions larger than 2-3 cm are plagued with high local recurrence rates and overall survival of these patients remains poor. Currently no adjuvant therapies exist to prevent local HCC recurrence in patients undergoing thermal ablation. The molecular mechanisms mediating HCC resistance to thermal ablation induced heat stress and local recurrence remain unclear. Here we demonstrate that the HCC cells with a poor prognostic hepatic stem cell subtype (Subtype HS) are more resistant to heat stress than HCC cells with a better prognostic hepatocyte subtype (Subtype HC)...
2016: PloS One
Gan Li, Mousen Cheng, Xiaokang Li
Polyoxymethylene (POM) decomposes gradually as it is heated up by the irradiation of CO<sub>2</sub> laser; the long-chain molecules of POM are broken into short chains, which leads to the lowering of the melting point and the critical temperature of the ablation products. When the product temperature is above the melting point, ablation comes up in the way of vaporization; when the product temperature is higher than the critical temperature, all liquid products are transformed into gas instantly and the ablation mechanism is changed...
September 1, 2016: Applied Optics
Qing-Yu Fan, Yong Zhou, Minghua Zhang, Baoan Ma, Tongtao Yang, Hua Long, Zhe Yu, Zhao Li
BACKGROUND: The current application of limb salvage process has some unsolved problems, such as prosthesis loosening, which severely limits the function of the preserved limbs. Innovative approaches are needed to further improve functional outcome. PATIENTS AND METHODS: Instead of en-bloc resection of tumor-bearing bone, it is dissected from the surrounding normal tissues, followed by devitalizing the bone segment and the extra-cortical bulk by microwave induced hyperthermia in situ through the antenna array...
2016: SpringerPlus
Marwan Moussa, S Nahum Goldberg, Gaurav Kumar, Tatyana Levchenko, Vladimir Torchilin, Muneeb Ahmed
PURPOSE: The aim of this study was to evaluate the effect of different radio-frequency ablation (RFA) thermal doses on coagulation and heat shock protein (HSP) response with and without adjuvant nanotherapies. MATERIALS AND METHODS: First, Fischer rats were assigned to nine different thermal doses of hepatic RFA (50-90 °C, 2-20 min, three per group) or no treatment (n = 3). Next, five of these RF thermal doses were combined with liposomal-doxorubicin (Lipo-Dox, 1 mg intravenously) in R3230 breast tumours, or no tumour treatment (five per group)...
December 2016: International Journal of Hyperthermia
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