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https://www.readbyqxmd.com/read/28647287/microwave-thermal-ablation-effects-of-tissue-properties-variations-on-predictive-models-for-treatment-planning
#1
Vanni Lopresto, Rosanna Pinto, Laura Farina, Marta Cavagnaro
Microwave thermal ablation (MTA) therapy for cancer treatments relies on the absorption of electromagnetic energy at microwave frequencies to induce a very high and localized temperature increase, which causes an irreversible thermal damage in the target zone. Treatment planning in MTA is based on experimental observations of ablation zones in ex vivo tissue, while predicting the treatment outcomes could be greatly improved by reliable numerical models. In this work, a fully dynamical simulation model is exploited to look at effects of temperature-dependent variations in the dielectric and thermal properties of the targeted tissue on the prediction of the temperature increase and the extension of the thermally coagulated zone...
June 21, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28646043/an-efficient-flp-based-toolkit-for-spatiotemporal-control-of-gene-expression-in-caenorhabditis-elegans
#2
Celia María Muñoz-Jiménez, Cristina Ayuso, Agnieszka Dobrzynska, Antonio Torres, Patricia de la Cruz Ruiz, Peter Askjaer
Site-specific recombinases are potent tools to regulate gene expression. In particular, the Cre and FLP enzymes are widely used to either activate or inactivate genes in a precise spatiotemporal manner. Both recombinases work efficiently in the popular model organism Caenorhabditis elegans but their use in this nematode is still only sporadic. To increase the utility of the FLP system in C. elegans we have generated a series of single-copy transgenic strains that stably express an optimized version of FLP in specific tissues or by heat induction...
June 23, 2017: Genetics
https://www.readbyqxmd.com/read/28643045/validation-of-a-mathematical-model-for-laser-induced-thermotherapy-in-liver-tissue
#3
F Hübner, C Leithäuser, B Bazrafshan, N Siedow, T J Vogl
The purpose of the study was to develop a simulation approach for laser-induced thermotherapy (LITT) that is based on mathematical models for radiation transport, heat transport, and tissue damage. The LITT ablation was applied to ex vivo pig liver tissue. Experiments were repeated with different laser powers, i.e., 22-34 W, and flow rates of the cooling water in the applicator system, i.e., 47-92 ml/min. During the procedure, the temperature was measured in the liver sample at different distances to the applicator as well as in the cooling circuit using a fiber optic thermometer...
June 22, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28642202/engineering-of-multifunctional-temperature-sensitive-liposomes-for-synergistic-photothermal-photodynamic-and-chemotherapeutic-effects
#4
Tuan Hiep Tran, Hanh Thuy Nguyen, Nam Van Le, Thi Thu Phuong Tran, Jong Seong Lee, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Heterogeneity of cancer cells and drug resistance require multiple therapeutic approaches for comprehensive treatment. In this study, temperature-sensitive liposomes containing anti-cancer agent tanespimycin (17-AAG) and photosensitizer IR 820 were developed for combination of phototherapy and chemotherapy. The temperature-sensitive liposomes composed of DPPC, cholesterol, DSPE-PEG, 17-AAG, and IR 820 (LP-AI) at weight ratio of 35/15/3/2/2 were formulated as a thin film using extrusion and evaluated for particle size, morphology and drug release profile...
June 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28640198/experimental-investigation-of-magnetic-nanoparticle-enhanced-microwave-hyperthermia
#5
Brogan T McWilliams, Hongwang Wang, Valerie J Binns, Sergio Curto, Stefan H Bossmann, Punit Prakash
The objective of this study was to evaluate microwave heating enhancements offered by iron/iron oxide nanoparticles dispersed within tissue-mimicking media for improving efficacy of microwave thermal therapy. The following dopamine-coated magnetic nanoparticles (MNPs) were considered: 10 and 20 nm diameter spherical core/shell Fe/Fe₃O₄, 20 nm edge-length cubic Fe₃O₄, and 45 nm edge-length/10 nm height hexagonal Fe₃O₄. Microwave heating enhancements were experimentally measured with MNPs dissolved in an agar phantom, placed within a rectangular waveguide...
June 22, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28633589/laser-induced-thermal-ablation-of-cancerous-cell-organelles
#6
Renat R Letfullin, Scott A Szatkowski
AIM: By exploiting the physical changes experienced by cancerous organelles, we investigate the feasibility of destroying cancerous cells by single and multipulse modes of laser heating. MATERIALS & METHODS: Our procedure consists of two primary steps: determining the normal and cancerous organelles optical properties and simulating the heating of all of the major organelles in the cell to find the treatment modes for the laser ablation of cancerous organelles without harming healthy cells...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28623988/rivaroxaban-for-thrombosis-prophylaxis-in-endovenous-laser-ablation-with-and-without-phlebectomy
#7
Heiko Uthoff, Daniel Holtz, Pavel Broz, Daniel Staub, Luca Spinedi
OBJECTIVE: Endovenous heat-induced thrombosis (EHIT) is a well-described complication of endovenous laser ablation (EVLA). We report our centers' experience on the efficacy (EHIT level ≥2 according to the Kabnick classification) and safety (observed major and minor bleeding events) of rivaroxaban for EHIT prophylaxis in EVLA with and without concomitant phlebectomy. METHODS: Demographic, procedural, and outcome data of all patients with EVLA of the great, accessory, or small saphenous vein and EHIT prophylaxis with 10 mg/d rivaroxaban between 2012 and 2014 were reviewed and analyzed in this investigator-initiated multicenter retrospective observational single-arm study...
July 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28614293/histone-deacetylase-3-prepares-brown-adipose-tissue-for-acute-thermogenic-challenge
#8
Matthew J Emmett, Hee-Woong Lim, Jennifer Jager, Hannah J Richter, Marine Adlanmerini, Lindsey C Peed, Erika R Briggs, David J Steger, Tao Ma, Carrie A Sims, Joseph A Baur, Liming Pei, Kyoung-Jae Won, Patrick Seale, Zachary Gerhart-Hines, Mitchell A Lazar
Brown adipose tissue is a thermogenic organ that dissipates chemical energy as heat to protect animals against hypothermia and to counteract metabolic disease. However, the transcriptional mechanisms that determine the thermogenic capacity of brown adipose tissue before environmental cold are unknown. Here we show that histone deacetylase 3 (HDAC3) is required to activate brown adipose tissue enhancers to ensure thermogenic aptitude. Mice with brown adipose tissue-specific genetic ablation of HDAC3 become severely hypothermic and succumb to acute cold exposure...
June 14, 2017: Nature
https://www.readbyqxmd.com/read/28611532/progress-towards-a-more-predictive-model-for-hohlraum-radiation-drive-and-symmetry
#9
O S Jones, L J Suter, H A Scott, M A Barrios, W A Farmer, S B Hansen, D A Liedahl, C W Mauche, A S Moore, M D Rosen, J D Salmonson, D J Strozzi, C A Thomas, D P Turnbull
For several years, we have been calculating the radiation drive in laser-heated gold hohlraums using flux-limited heat transport with a limiter of 0.15, tabulated values of local thermodynamic equilibrium gold opacity, and an approximate model for not in a local thermodynamic equilibrium (NLTE) gold emissivity (DCA_2010). This model has been successful in predicting the radiation drive in vacuum hohlraums, but for gas-filled hohlraums used to drive capsule implosions, the model consistently predicts too much drive and capsule bang times earlier than measured...
May 2017: Physics of Plasmas
https://www.readbyqxmd.com/read/28610455/non-fourier-thermal-transport-induced-structural-hierarchy-and-damage-to-collagen-ultrastructure-subjected-to-laser-irradiation
#10
Nilamani Sahoo, Arunn Narasimhan, Purbarun Dhar, Sarit Kumar Das
Comprehending the mechanism of thermal transport through biological tissues is an important factor for optimal ablation of cancerous tissues and minimising collateral tissue damage. The present study reports detailed mapping of the rise in internal temperature within the tissue mimics due to NIR (1064 nm) laser irradiation, both for bare mimics and with gold nanostructures infused. Gold nanostructures such as mesoflowers and nano spheres have been synthesized and used as photothermal converters to enhance the temperature rise, resulting in achieving the desired degradation of malignant tissue in targeted region...
June 13, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28606782/role-of-peripheral-and-central-trpv1-receptors-in-facial-heat-hyperalgesia-in-streptozotocin-induced-diabetic-rats
#11
Erika IvannaAraya, Carina Fernanda MattediNones, Luiz Eduardo Nunes Ferreira, Caroline Machado Kopruszinski, Joice Maria da Cunha, Juliana GeremiasChichorro
There is increasing evidence that diabetes may be related to sensory changes in the trigeminal system. Long lasting facial heat hyperalgesia has been described in diabetic rats, but the mechanisms remain to be elucidated. Herein, the contribution of peripheral and central TRPV1 receptors to facial heat hyperalgesia in diabeticrats was investigated. Diabetes was induced in male Wistar rats by streptozotocin (60 mg/kg, i.p) and facial heat hyperalgesia was assessed once a week up to four weeks. The role of TRPV1 receptors in the heat hyperalgesia in diabetic rats was evaluated through: 1) the ablation of TRPV1 receptors by resiniferatoxin (RTX) treatment and 2) injection of the TRPV1 antagonist,capsazepine, into the upper lip, trigeminal ganglion or medullary subarachnoid space, at doses that completed prevented the heat hyperalgesia induced by capsaicin in naïve rats...
June 9, 2017: Brain Research
https://www.readbyqxmd.com/read/28604815/temperature-sensitive-liposomes-combined-with-thermal-ablation-effects-of-duration-and-timing-of-heating-in-mathematical-models-and-in-vivo
#12
Christian Rossmann, M A McCrackin, Kent E Armeson, Dieter Haemmerich
BACKGROUND: Temperature sensitive liposomes (TSL) are nanoparticles that rapidly release the contained drug at hyperthermic temperatures, typically above ~40°C. TSL have been combined with various heating modalities, but there is no consensus on required hyperthermia duration or ideal timing of heating relative to TSL administration. The goal of this study was to determine changes in drug uptake when heating duration and timing are varied when combining TSL with radiofrequency ablation (RF) heating...
2017: PloS One
https://www.readbyqxmd.com/read/28590837/regulation-and-measurement-of-the-heat-generated-by-automatic-tooth-preparation-in-a-confined-space
#13
Fusong Yuan, Jianqiao Zheng, Yuchun Sun, Yong Wang, Peijun Lyu
OBJECTIVE: The aim of this study was to assess and regulate heat generation in the dental pulp cavity and circumambient temperature around a tooth during laser ablation with a femtosecond laser in a confined space. BACKGROUND DATA: The automatic tooth preparing technique is one of the traditional oral clinical technology innovations. In this technique, a robot controlled an ultrashort pulse laser to automatically complete the three-dimensional teeth preparing in a confined space...
June 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28582774/a-giant-planet-undergoing-extreme-ultraviolet-irradiation-by-its-hot-massive-star-host
#14
B Scott Gaudi, Keivan G Stassun, Karen A Collins, Thomas G Beatty, George Zhou, David W Latham, Allyson Bieryla, Jason D Eastman, Robert J Siverd, Justin R Crepp, Erica J Gonzales, Daniel J Stevens, Lars A Buchhave, Joshua Pepper, Marshall C Johnson, Knicole D Colon, Eric L N Jensen, Joseph E Rodriguez, Valerio Bozza, Sebastiano Calchi Novati, Giuseppe D'Ago, Mary T Dumont, Tyler Ellis, Clement Gaillard, Hannah Jang-Condell, David H Kasper, Akihiko Fukui, Joao Gregorio, Ayaka Ito, John F Kielkopf, Mark Manner, Kyle Matt, Norio Narita, Thomas E Oberst, Phillip A Reed, Gaetano Scarpetta, Denice C Stephens, Rex R Yeigh, Roberto Zambelli, B J Fulton, Andrew W Howard, David J James, Matthew Penny, Daniel Bayliss, Ivan A Curtis, D L DePoy, Gilbert A Esquerdo, Andrew Gould, Michael D Joner, Rudolf B Kuhn, Jonathan Labadie-Bartz, Michael B Lund, Jennifer L Marshall, Kim K McLeod, Richard W Pogge, Howard Relles, Christopher Stockdale, T G Tan, Mark Trueblood, Patricia Trueblood
The amount of ultraviolet irradiation and ablation experienced by a planet depends strongly on the temperature of its host star. Of the thousands of extrasolar planets now known, only six have been found that transit hot, A-type stars (with temperatures of 7,300-10,000 kelvin), and no planets are known to transit the even hotter B-type stars. For example, WASP-33 is an A-type star with a temperature of about 7,430 kelvin, which hosts the hottest known transiting planet, WASP-33b (ref. 1); the planet is itself as hot as a red dwarf star of type M (ref...
June 22, 2017: Nature
https://www.readbyqxmd.com/read/28577771/cryotherapy-for-barrett-s-esophagus
#15
REVIEW
Marcia Irene Canto
Cryotherapy or cryoablation involves the freezing of tissues to destroy unwanted tissue or to control bleeding. Endoscopic cryotherapy has been developed for gastrointestinal application by through-the-scope noncontact delivery of compressed carbon dioxide gas or liquid nitrogen (cryospray) or contact balloon cryoablation. The mechanism of cryotherapy ablative effects includes immediate injury as well as coagulation necrosis occurring over several hours and days, unlike heat-based thermal ablation. This article reviews the basis, technique, safety, efficacy, and durability for the use of endoscopic cryotherapy in Barrett's esophagus and esophageal adenocarcinoma...
July 2017: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/28566498/thermal-combination-therapies-for-local-drug-delivery-by-magnetic-resonance-guided-high-intensity-focused-ultrasound
#16
Nicole Hijnen, Esther Kneepkens, Mariska de Smet, Sander Langereis, Edwin Heijman, Holger Grüll
Several thermal-therapy strategies such as thermal ablation, hyperthermia-triggered drug delivery from temperature-sensitive liposomes (TSLs), and combinations of the above were investigated in a rhabdomyosarcoma rat tumor model (n = 113). Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) was used as a noninvasive heating device with precise temperature control for image-guided drug delivery. For the latter, TSLs were prepared, coencapsulating doxorubicin (dox) and [Gd(HPDO3A)(H2O)], and injected in tumor-bearing rats before MR-HIFU treatment...
June 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28557798/thermal-ablation-of-a-confluent-lesion-in-the-porcine-kidney-with-a-clinically-available-mr-hifu-system
#17
J M M van Breugel, M de Greef, J W Wijlemans, G Schubert, M A A J van den Bosch, C T W Moonen, M G Ries
The incidence of small renal masses (SRMs) sized  <4 cm has increased over the decades (as co-findings/or due to introduction of cross sectional imaging). Currently, partial nephrectomy (PN) or watchful waiting is advised in these patients. Ultimately, 80-90% of these SRMs require surgical treatment and PN is associated with a 15% complication rate. In this aging population, with possible comorbidities and poor health condition, both PN and watchful waiting are non-ideal treatment options. This resulted in an increased need for early, non-invasive treatment strategies such as MR-guided high intensity focused ultrasound (MR-HIFU)...
July 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28554243/functional-interactions-between-transient-receptor-potential-m8-and-transient-receptor-potential-v1-in-the-trigeminal-system-relevance-to-migraine-pathophysiology
#18
Yohei Kayama, Mamoru Shibata, Tsubasa Takizawa, Keiji Ibata, Toshihiko Shimizu, Taeko Ebine, Haruki Toriumi, Michisuke Yuzaki, Norihiro Suzuki
Background Recent genome-wide association studies have identified transient receptor potential M8 ( TRPM8) as a migraine susceptibility gene. TRPM8 is a nonselective cation channel that mediates cool perception. However, its precise role in migraine pathophysiology is elusive. Transient receptor potential V1 (TRPV1) is a nonselective cation channel activated by noxious heat. Both TRPM8 and TRPV1 are expressed in trigeminal ganglion (TG) neurons. Methods We investigated the functional roles of TRPM8 and TRPV1 in a meningeal inflammation-based migraine model by measuring the effects of facial TRPM8 activation on thermal allodynia and assessing receptor coexpression changes in TG neurons...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28554240/numerical-analysis-of-thermal-impact-of-intramyocardial-capillary-blood-flow-during-radiofrequency-cardiac-ablation
#19
Juan J Pérez, Ana González-Suárez, Enrique Berjano
PURPOSE: The thermal effect of the intramyocardial blood perfusion on the size of lesions created by radiofrequency cardiac ablation (RFCA) has not been adequately studied to date. Our objective was to assess the impact of including this phenomenon in RFCA computer modelling in terms of the thermal lesion depth created. METHODS: A computer model was built and computer simulations were conducted to assess the effect of including the blood perfusion term in the bioheat equation...
June 18, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28545303/a-thermoelastic-deformation-model-of-tissue-contraction-during-thermal-ablation
#20
Chang Sub Park, Cong Liu, Sheldon K Hall, Stephen J Payne
PURPOSE: Thermal ablation is an energy-based ablation technique widely used during minimally invasive cancer treatment. Simulations are used to predict the dead tissue post therapy. However, one difficulty with the simulations is accurately predicting the ablation zone in post-procedural images due to the contraction of tissue as a result of exposure to elevated temperatures. MATERIALS AND METHODS: A mathematical model of the thermoelastic deformation for an elastic isotropic material was coupled with a three state thermal denaturation model to determine the contraction of tissue during thermal ablation...
June 14, 2017: International Journal of Hyperthermia
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