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https://www.readbyqxmd.com/read/29653369/biocompatible-fe-3-ta-coordination-complex-with-high-photothermal-conversion-efficiency-for-ablation-of-cancer-cells
#1
Pei-Ying Liu, Zhao-Hua Miao, Kai Li, Huanjie Yang, Liang Zhen, Cheng-Yan Xu
Near-infrared (NIR) light absorbing nanomaterials, which can convert light to heat energy, have great prospects in biomedical applications. In the current work, Fe3+ -TA (Tannic Acid) coordination complex formed by simple mixing of tannic acid and FeCl3 solutions was explored as a novel photothermal agent. Due to the strong absorbance in the near-infrared region induced by the coordination effect between TA molecule and Fe3+ ion, the as-prepared Fe3+ -TA complex exhibited excellent photothermal performance with high photothermal conversion efficiency of 77...
March 22, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29652390/integrated-catheter-for-simultaneous-radio-frequency-ablation-and-optoacoustic-monitoring-of-lesion-progression
#2
Johannes Rebling, Francisco Javier Oyaga Landa, Xosé Luís Deán-Ben, Alexandre Douplik, Daniel Razansky
Radio frequency (RF) catheter ablation is commonly used to eliminate dysfunctional cardiac tissue by heating via an alternating current. Clinical outcomes are highly dependent on careful anatomical guidance, electrophysiological mapping, and careful RF power titration during the procedure. Yet, current treatments rely mainly on the expertise of the surgeon to assess lesion formation, causing large variabilities in the success rate. We present an integrated catheter design suitable for simultaneous RF ablation and real-time optoacoustic monitoring of the forming lesion...
April 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29619610/ultrasound-thermal-monitoring-with-an-external-ultrasound-source-for-customized-bipolar-rf-ablation-shapes
#3
Younsu Kim, Chloé Audigier, Jens Ziegle, Michael Friebe, Emad M Boctor
PURPOSE: Thermotherapy is a clinical procedure which delivers thermal energy to a target, and it has been applied for various medical treatments. Temperature monitoring during thermotherapy is important to achieve precise and reproducible results. Medical ultrasound can be used for thermal monitoring and is an attractive medical imaging modality due to its advantages including non-ionizing radiation, cost-effectiveness and portability. We propose an ultrasound thermal monitoring method using a speed-of-sound tomographic approach coupled with a biophysical heat diffusion model...
April 4, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29618475/novel-measure-of-local-impedance-predicts-catheter-tissue-contact-and-lesion-formation
#4
Matthew S Sulkin, Jacob I Laughner, Sebastian Hilbert, Suraj Kapa, Jedrzej Kosiuk, Paul Younan, Iñaki Romero, Allan Shuros, Jason J Hamann, Gerhard Hindricks, Andreas Bollmann
BACKGROUND: Coupling between the ablation catheter and myocardium is critical to resistively heat tissue with radiofrequency ablation. The objective of this study was to evaluate whether a novel local impedance (LI) measurement on an ablation catheter identifies catheter-tissue coupling and is predictive of lesion formation. METHODS AND RESULTS: LI was studied in explanted hearts (n=10 swine) and in vivo (n=10; 50-70 kg swine) using an investigational electroanatomic mapping system that measures impedance from an ablation catheter with mini-electrodes incorporated in the distal electrode (Rhythmia and IntellaNav MiFi OI, Boston Scientific)...
April 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29582583/a-cascade-targeting-nanocapsule-for-enhanced-photothermal-tumor-therapy-with-aid-of-autophagy-inhibition
#5
Xilong Wu, Yundi Wu, Zhiyong Wang, Lixin Liu, Chengxin Sun, Yongming Chen, Chun Wang
Autophagy is a homeostatic lysosome-dependent metabolic process to eliminate damaged or dysfunctional cellular organelles, which is closely associated with tumor progression. Indocyanine green (ICG) can convert NIR light energy to localized heat for cancer cell and tissue ablation. However, the effect of autophagy modulation on ICG-mediated photothermal therapy remains unknown. In this study, it is found that primaquine (PQ) suppresses autophagy flux at a late stage through the impeding fusion of the autophagosome with the lysosome to form an autophagolysosome, leading to cell apoptosis or necrosis...
March 27, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29580951/modality-specific-peripheral-antinociceptive-effects-of-%C3%AE-opioid-agonists-on-heat-and-mechanical-stimuli-contribution-of-sigma-1-receptors
#6
Ángeles Montilla-García, Gloria Perazzoli, Miguel Á Tejada, Rafael González-Cano, Cristina Sánchez-Fernández, Enrique J Cobos, José M Baeyens
Morphine induces peripherally μ-opioid-mediated antinociception to heat but not to mechanical stimulation. Peripheral sigma-1 receptors tonically inhibit μ-opioid antinociception to mechanical stimuli, but it is unknown whether they modulate μ-opioid heat antinociception. We hypothesized that sigma-1 receptors might play a role in the modality-specific peripheral antinociceptive effects of morphine and other clinically relevant μ-opioid agonists. Mechanical nociception was assessed in mice with the paw pressure test (450 g), and heat nociception with the unilateral hot plate (55 °C) test...
March 23, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29578166/the-effect-of-temperature-control-microwave-on-hela-and-mg-63-cells
#7
Zhenwei Ji, Yunlei Ma, Haien Zhao, Wei Li, Xiaoxiang Li, Zhe Yun, Guangyi Zhao, Baoan Ma, Qingyu Fan
Context: Hyperthermia has now been used to treat many kinds of solid malignancies. However, the applied thermal parameters about heat temperature and time varied all over the world, and no consensus about the optimal formula had been reached. Microwave ablation, as one of thermal ablation methods, is usually applied based on the fixed parameters of power and duration. As a result, too high temperature or overheating might not be avoided and excessive heating might cause some additional side effects to normal tissues...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29578086/batio-3-core-au-shell-nanoparticles-for-photothermal-therapy-and-bimodal-imaging
#8
Yanfei Wang, Aoune Barhoumi, Rong Tong, Weiping Wang, Tianjiao Ji, Xiaoran Deng, Lele Li, Sophie A Lyon, Gally Reznor, David Zurakowski, Daniel S Kohane
We report sub-100 nm metal-shell (Au) dielectric-core (BaTiO3 ) nanoparticles with bimodal imaging abilities and enhanced photothermal effects. The nanoparticles efficiently absorb light in the near infrared range of the spectrum and convert it to heat to ablate tumors. Their BaTiO3 core, a highly ordered non-centrosymmetric material, can be imaged by second harmonic generation, and their Au shell generates two-photon luminescence. The intrinsic dual imaging capability allows investigating the distribution of the nanoparticles in relation to the tumor vasculature morphology during photothermal ablation...
March 22, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29577893/participation-of-transient-receptor-potential-vanilloid-1-in-paclitaxel-induced-acute-visceral-and-peripheral-nociception-in-rodents
#9
Mateus Fortes Rossato, Flavia Karine Rigo, Sara Marchesan Oliveira, Gustavo Petri Guerra, Cássia Regina Silva, Thiago Mattar Cunha, Marcus Vinícius Gomez, Juliano Ferreira, Gabriela Trevisan
The clinical use of paclitaxel as a chemotherapeutic agent is limited by the severe acute and chronic hypersensitivity caused when it is administered via intraperitoneal or intravenous routes. Thus far, evidence has suggested that transient receptor potential vanilloid-1 (TRPV1) has a key role in the chronic neuropathy induced by paclitaxel. Despite this, the role of TRPV1 in paclitaxel -related acute nociception, especially the development of visceral nociception, has not been evaluated. Thus, the goal of this study was to evaluate the participation of TRPV1 in a model of acute nociception induced by paclitaxel in rats and mice...
March 22, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29566612/defeating-cancers-adaptive-defensive-strategies-using-thermal-therapies-examining-cancer-s-therapeutic-resistance-ablative-and-computational-modeling-strategies-as-a-means-for-improving-therapeutic-outcome
#10
John M Baust, Yoed Rabin, Thomas J Polascik, Kimberly L Santucci, Kristi K Snyder, Robert G Van Buskirk, John G Baust
BACKGROUND: Diverse thermal ablative therapies are currently in use for the treatment of cancer. Commonly applied with the intent to cure, these ablative therapies are providing promising success rates similar to and often exceeding "gold standard" approaches. Cancer-curing prospects may be enhanced by deeper understanding of thermal effects on cancer cells and the hosting tissue, including the molecular mechanisms of cancer cell mutations, which enable resistance to therapy...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29559743/stress-induced-phosphoprotein-1-mediates-hepatocellular-carcinoma-metastasis-after-insufficient-radiofrequency-ablation
#11
Tianhong Su, Junbin Liao, Zihao Dai, Lixia Xu, Shuling Chen, Yifei Wang, Zhenwei Peng, Qiuyang Zhang, Sui Peng, Ming Kuang
Recent studies indicated that insufficient radiofrequency ablation (RFA) could endow hepatocellular carcinoma (HCC) with higher aggressive potential. Stress-induced phosphoprotein 1 (STIP1), which was found highly expressed in HCC, is a chaperone molecule mediating cell homeostasis under thermal stress. We aimed to explore the role of STIP1 on the metastasis of residual HCC after RFA. Mice model with orthotopic HCC implants or caudal vein injection were employed to assess potential of lung metastasis and/or intrahepatic metastasis (IHM) of HCC cells...
March 21, 2018: Oncogene
https://www.readbyqxmd.com/read/29548342/an-efficient-antimicrobial-depot-for-infectious-site-targeted-chemo-photothermal-therapy
#12
Menglong Liu, Danfeng He, Tao Yang, Wei Liu, Li Mao, Yang Zhu, Jun Wu, Gaoxing Luo, Jun Deng
BACKGROUND: Silver and photothermal therapy (PTT) have been widely used for eradicating the drug-resistant bacteria. However, the risks of excess of silver for humans and the low efficiency of PTT still limit their in vivo therapeutic application. Integration of two distinctive bactericides into one entity is a promising platform to improve the efficiency of antimicrobial agents. RESULTS: In this study, a chemo-photothermal therapeutic platform based on polydopamine (PDA)-coated gold nanorods (GNRs) was developed...
March 16, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29533788/biomaterial-scaffolds-for-non-invasive-focal-hyperthermia-as-a-potential-tool-to-ablate-metastatic-cancer-cells
#13
Francisco Pelaez, Navid Manuchehrabadi, Priyatanu Roy, Harishankar Natesan, Yiru Wang, Emilian Racila, Heather Fong, Kevin Zeng, Abby M Silbaugh, John C Bischof, Samira M Azarin
Currently, there are very few therapeutic options for treatment of metastatic disease, as it often remains undetected until the burden of disease is too high. Microporous poly(ε-caprolactone) biomaterials have been shown to attract metastasizing breast cancer cells in vivo early in tumor progression. In order to enhance the therapeutic potential of these scaffolds, they were modified such that infiltrating cells could be eliminated with non-invasive focal hyperthermia. Metal disks were incorporated into poly(ε-caprolactone) scaffolds to generate heat through electromagnetic induction by an oscillating magnetic field within a radiofrequency coil...
February 28, 2018: Biomaterials
https://www.readbyqxmd.com/read/29531966/lesion-modeling-characterization-and-visualization-for-image-guided-cardiac-ablation-therapy-monitoring
#14
Cristian A Linte, Jon J Camp, Maryam E Rettmann, Dieter Haemmerich, Mehmet K Aktas, David T Huang, Douglas L Packer, David R Holmes
In spite of significant efforts to improve image-guided ablation therapy, a large number of patients undergoing ablation therapy to treat cardiac arrhythmic conditions require repeat procedures. The delivery of insufficient thermal dose is a significant contributor to incomplete tissue ablation, in turn leading to the arrhythmia recurrence. Ongoing research efforts aim to better characterize and visualize RF delivery to monitor the induced tissue damage during therapy. Here, we propose a method that entails modeling and visualization of the lesions in real-time...
April 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29525229/automated-geometric-optimization-for-robotic-hifu-treatment-of-liver-tumors
#15
Tom Williamson, Scott Everitt, Sunita Chauhan
BACKGROUND: High intensity focused ultrasound (HIFU) represents a non-invasive method for the destruction of cancerous tissue within the body. Heating of targeted tissue by focused ultrasound transducers results in the creation of ellipsoidal lesions at the target site, the locations of which can have a significant impact on treatment outcomes. Towards this end, this work describes a method for the optimization of lesion positions within arbitrary tumors, with specific anatomical constraints...
February 26, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29515702/mid-term-report-on-the-safety-and-effectiveness-of-endovenous-radiofrequency-ablation-for-varicose-veins
#16
Kiyoshi Tamura, Toshiyuki Maruyama
Objective : Endovenous radiofrequency ablation (RFA), a relatively new technique for treating great saphenous varicose veins, is less invasive compared with stripping surgery. This study examined the mid-term safety and effectiveness of RFA for varicose veins. Materials and Methods : We enrolled 104 patients (147 limbs) who underwent RFA for varicose veins of the lower extremities (females, 67; 64.4%). The mean age was 68.9±9.2 years (39-85 years). In 121 limbs (82.3%), there were great saphenous veins. All patients were observed as outpatients for 12 months after the procedure...
December 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29506903/a-comparison-of-bleeding-complications-in-patients-undergoing-percutaneous-renal-cryoablation-using-cryoprobes-with-and-without-heat-based-track-ablation
#17
Collin H Schmit, Matthew R Callstrom, Stephen A Boorjian, Matthew P Johnson, Thomas D Atwell, A Nicholas Kurup, Georgianna R Schultz, R Houston Thompson, Grant D Schmit
PURPOSE: To determine if the use of heat-based track ablation with new-generation cryoprobes is associated with decreased renal cryoablation bleeding complications. MATERIALS AND METHODS: Eighty-nine patients who underwent percutaneous cryoablation for treatment of a solitary renal mass with the use of cryoprobes with track ablation (CwTA) from October 29, 2015, to May 18, 2017, were compared with a propensity score-matched control group of 178 patients who underwent treatment with the use of cryoprobes without track ablation (Cw/oTA) from January 5, 2012, to October 28, 2015...
March 3, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29501175/laser-assisted-in-situ-synthesis-of-graphene-based-magnetic-responsive-hybrids-for-multimodal-imaging-guided-chemo-photothermal-synergistic-therapy
#18
Mei-Ling Chen, Zhi-Wen Gao, Xue-Min Chen, Shu-Chao Pang, Yi Zhang
Magnetic graphene-based hybrids are being increasing recognized as an effective nanotheranostic agent in biomedicine. Conventional technologies for their synthesis have drawbacks not only from a synthetic standpoint, mainly requiring high temperatures and multi-step processes, but also from a biological perspective, chemical precursors or surfactants involved in the chemical process are toxic to cells. Herein, we report a novel approach for one-step fabricating magnetic graphene hybrid nanocomposites based on laser irradiation of an Fe target in GO-PEG aqueous solution at room temperature without using any other chemical reagent...
May 15, 2018: Talanta
https://www.readbyqxmd.com/read/29490524/high-power-microwave-ablation-of-normal-swine-lung-impact-of-duration-of-energy-delivery-on-adverse-event-and-heat-sink-effects
#19
Hiroshi Kodama, Eisuke Ueshima, Song Gao, Sebastien Monette, Lee-Ronn Paluch, Kreg Howk, Joseph P Erinjeri, Stephen B Solomon, Govindarajan Srimathveeravalli
PURPOSE: To assess the impact of duration of energy delivery on adverse events (AEs) and heat sink effects during high power microwave ablation (MWA) of normal swine lung. MATERIALS AND METHODS: High power (100 Watts) MWA was performed with short (2 minutes, 18 ablations) or long (10 minutes, 9 ablations) duration of energy delivery in unilateral lung of swine (n = 10). CT imaging was done prior to sacrifice at 2 or 28 days post-treatment, with additional imaging at 7 and 14 days for the latter cohort...
February 28, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29469827/investigations-on-surface-morphology-and-bandgap-engineering-of-single-crystal-boron-doped-silicon-irradiated-by-a-nanosecond-laser
#20
Maryam Sardar, Chen Jun, Zaka Ullah, Aasma Tabassum, Mohsan Jelani, Ju Cheng, Yuxiang Sun, Xueming Lv, Lu Jian
We irradiate the single crystal boron-doped silicon (Si) at various laser fluences with 100 laser shots in ambient air at room temperature using an Nd:YAG laser and investigate its surface morphology and optical properties. The optical microscopy gives evidence of the formation of a crater and reveals that the heat-affected zone and melted area are increased with increase in laser fluence from 1.1 to 15.4  J/cm2 . The micrographs obtained by scanning electron microscopy (SEM) show that the micro- and nano-structures such as microcracks, bubbles, nucleation sites, clusters, redeposited layered material, nanoparticles, and alike water droplet structures are formed on a laser-exposed Si surface...
February 20, 2018: Applied Optics
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