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https://www.readbyqxmd.com/read/29456098/arf-excimer-laser-debrides-burns-without-destruction-of-viable-tissue-a-pilot-study
#1
Atulya Prasad, Katarzyna M Sawicka, Kelly B Pablo, Lauren K Macri, Jerome Felsenstein, James J Wynne, Richard A F Clark
INTRODUCTION: Recent evidence indicates that early removal of eschar by tangential debridement can promote healing. Laser debridement can be used for debridement of areas that prove challenging for debridement using tangential excision. In particular, irradiation with an ArF excimer laser ablates desiccated eschar and is self-terminating, preserving hydrated or viable tissue. METHODS: Thermal burns were created on the flanks of two outbred, female Yorkshire pigs using aluminum bars heated to 70°C and applied for different lengths of time...
February 15, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29451124/copper-oxide-loaded-plga-nanospheres-towards-a-multifunctional-nanoscale-platform-for-ultrasound-based-imaging-and-therapy
#2
Or Perlman, Iris S Weitz, Sarit Sivan, Hiba Abu-Khalla, Madeleine Benguigui, Yuval Shaked, Haim Azhari
Copper oxide nanoparticles (CuO-NPs) are increasingly investigated for diagnostic and therapeutic purposes. Recent work have demonstrated their anticancer potential as well as contrast agent capabilities for magnetic resonance imaging (MRI) and through-transmission ultrasound. However, no capabilities of CuO-NPS were demonstrated using conventional ultrasound systems, which, unlike the formers, are widely deployed in the clinic. Furthermore, in spite of their potential as multifunctional nano-based materials for diagnosis and therapy, CuO-NPs were delayed from further clinical translation due to their inherent toxicity...
February 16, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29448895/the-outcome-of-anticoagulation-on-endovenous-laser-therapy-for-superficial-venous-incompetence
#3
Jamie Vatish, Nusrat Iqbal, Viswa Retnasingam Rajalingam, Alok Tiwari
OBJECTIVES: The purpose of this study was to evaluate whether anticoagulation (warfarin or direct oral inhibitors) affected the success of endovenous treatment. METHODS: Patients taking anticoagulation (warfarin or direct oral inhibitors) undergoing endovenous treatment in the form of endovenous laser ablation (EVLA) were matched against controls for sex, age, leg, and vein. Data were collected prospectively between January 2012 and March 2017. The primary endpoint was failure of treatment at 6-week postoperative duplex scan...
January 1, 2018: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29441813/understanding-the-nuances-of-microwave-ablation-for-more-accurate-post-treatment-assessment
#4
Christy Kim
Microwave ablation (MWA) is a relatively new thermal modality for minimally invasive procedures compared with radiofrequency ablation. Although MWA and radiofrequency ablation are thermal modalities, their underlying physics and principles greatly differ. Consequently, it is imperative that clinicians be aware of how these differences impact realized ablation volumes to consistently ensure technical success and better patient outcomes. This paper will review the nuances specific to MWA technology (i.e., tissue properties, perfusion/heat sink effect, ablation assessment, imaging accuracy and tissue contraction) that are often overlooked based on familiarity with conventional thermal modalities to guide more accurate assessment of post-treatment MWA volumes...
February 14, 2018: Future Oncology
https://www.readbyqxmd.com/read/29435018/thermographic-real-time-monitoring-of-surgical-radiofrequency-and-microwave-ablation-in-a-perfused-porcine-liver-model
#5
Florian Primavesi, Stefan Swierczynski, Eckhard Klieser, Tobias Kiesslich, Tarkan Jäger, Romana Urbas, Jörg Hutter, Daniel Neureiter, Dietmar Öfner, Stefan Stättner
Radiofrequency ablation (RFA) and microwave ablation (MWA) are currently the dominant modalities to treat unresectable liver tumors. Monitoring the ablation process with b-mode-sonography is often hampered by artefacts. Furthermore, vessels may cause cooling in the adjacent tumor target (heat-sink-effect) with risk of local recurrence. The present study evaluated infrared-thermography to monitor surgical RFA/MWA and detect heat-sink-effects in real-time. RFA and MWA of perfused porcine livers was conducted at peripheral and central-vessel-adjacent locations, and monitored by real-time thermography...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434428/evaluation-of-endovenous-laser-ablation-for-varicose-veins-using-a-computer-simulation-model-secondary-publication
#6
REVIEW
Hisanao Hazama, Masato Yoshimori, Norihiro Honda, Kunio Awazu
Background and aims: Endovenous laser ablation (EVLA) has been well-reported as a minimally invasive method to deal with varices of the lower extremities. The lasers used fall into two categories: pigment, i.e., hemoglobin-specific lasers in the visible and near-infrared (near-IR) wavebands and longer wavelength mid-infrared lasers where the chromophore is water. The fiber used to deliver the laser energy is also important, and not enough attention has been paid to this element of EVLA...
December 31, 2017: Laser Therapy
https://www.readbyqxmd.com/read/29433909/heat-shock-protein-90-inhibitor-enhances-apoptosis-by-inhibiting-the-akt-pathway-in-thermal-stimulated-sk-mel-2-human-melanoma-cell-line
#7
Min Kyung Shin, Ki-Heon Jeong, Hyeongwon Choi, Hye-Jin Ahn, Mu-Hyoung Lee
BACKGROUND: Heat shock proteins (Hsps) are chaperone proteins, which are upregulated after various stresses. Hsp90 inhibitors have been investigated as adjuvant therapies for the treatment of melanoma. Thermal ablation could be a treatment option for surgically unresectable melanoma or congenital nevomelanocytic nevi, however, there is a limitation such as the possibility of recurrence. OBJECTIVE: We evaluated apoptosis in a melanoma cell line treated with the Hsp90 inhibitor 17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), in hyperthermic conditions...
February 8, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29433060/dual-tumor-targeted-multifunctional-magnetic-hyaluronic-acid-micelles-for-enhanced-mr-imaging-and-combined-photothermal-chemotherapy
#8
Shaohui Zheng, Jiwon Han, Zhen Jin, Chang-Sei Kim, Sukho Park, Kyu-Pyo Kim, Jong-Oh Park, Eunpyo Choi
Multifunctional polymeric micelles were developed as a promising dual tumor-targeted drug delivery platform for magnetic resonance (MR) imaging and combined photothermal-chemotherapy. HA-C16 copolymers were synthesized via peptide formation process with subsequent co-encapsulation of therapeutic agent docetaxel (DTX) and superparamagnetic iron oxide nanoparticles (SPIONs) to form the multifunctional micelles. The micelles exhibited uniform nanosize and remarkable colloidal stability in aqueous solution. The sustained drug release behavior from HA micelles was observed over the test period...
February 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29429934/immune-or-genetic-mediated-disruption-of-caspr2-causes-pain-hypersensitivity-due-to-enhanced-primary-afferent-excitability
#9
John M Dawes, Greg A Weir, Steven J Middleton, Ryan Patel, Kim I Chisholm, Philippa Pettingill, Liam J Peck, Joseph Sheridan, Akila Shakir, Leslie Jacobson, Maria Gutierrez-Mecinas, Jorge Galino, Jan Walcher, Johannes Kühnemund, Hannah Kuehn, Maria D Sanna, Bethan Lang, Alex J Clark, Andreas C Themistocleous, Noboru Iwagaki, Steven J West, Karolina Werynska, Liam Carroll, Teodora Trendafilova, David A Menassa, Maria Pia Giannoccaro, Ester Coutinho, Ilaria Cervellini, Damini Tewari, Camilla Buckley, M Isabel Leite, Hendrik Wildner, Hanns Ulrich Zeilhofer, Elior Peles, Andrew J Todd, Stephen B McMahon, Anthony H Dickenson, Gary R Lewin, Angela Vincent, David L Bennett
Human autoantibodies to contactin-associated protein-like 2 (CASPR2) are often associated with neuropathic pain, and CASPR2 mutations have been linked to autism spectrum disorders, in which sensory dysfunction is increasingly recognized. Human CASPR2 autoantibodies, when injected into mice, were peripherally restricted and resulted in mechanical pain-related hypersensitivity in the absence of neural injury. We therefore investigated the mechanism by which CASPR2 modulates nociceptive function. Mice lacking CASPR2 (Cntnap2-/- ) demonstrated enhanced pain-related hypersensitivity to noxious mechanical stimuli, heat, and algogens...
February 1, 2018: Neuron
https://www.readbyqxmd.com/read/29425144/fully-solution-processable-fabrication-of-multi-layered-circuits-on-a-flexible-substrate-using-laser-processing
#10
Seok Young Ji, Wonsuk Choi, Hoon-Young Kim, Jin-Woo Jeon, Sung-Hak Cho, Won Seok Chang
The development of printing technologies has enabled the realization of electric circuit fabrication on a flexible substrate. However, the current technique remains restricted to single-layer patterning. In this paper, we demonstrate a fully solution-processable patterning approach for multi-layer circuits using a combined method of laser sintering and ablation. Selective laser sintering of silver (Ag) nanoparticle-based ink is applied to make conductive patterns on a heat-sensitive substrate and insulating layer...
February 9, 2018: Materials
https://www.readbyqxmd.com/read/29410693/intra-renal-splenosis-mimicking-a-solid-renal-mass
#11
Ethan A Neufeld, Simran Sekhon, Eugenio O Gerscovich
We present the case of a young woman found to have an exophytic solid renal mass who was referred to our institution for ablation of said mass versus partial nephrectomy. The patient had a history of splenectomy. Ultrasound demonstrated a homogeneous solid left renal mass, and the diagnosis of intra-renal splenosis was considered based on the patient's history. The diagnosis was confirmed using Tc-99 m heat-damaged red blood cell scintigraphy, obviating the need for an invasive procedure. The diagnosis of intra-renal splenosis should be considered for a solid renal mass with an appropriate history of prior splenic trauma or splenectomy...
August 2017: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/29402074/multifunctional-porous-iron-oxide-nanoagents-for-mri-and-photothermal-chemo-synergistic-therapy
#12
Yayun Hu, Hai Hu, Jun Yan, Chao Zhang, Yonggang Li, Mengyun Wang, Weiyi Tan, Jian Liu, Yue Pan
Nanoagents of integrating multiple imaging and therapeutic modalities have attracted tremendous attention for biomedical applications. Herein, we synthesize porous hollow Fe3O4 as a theranostic agent for combined photothermal/chemo cancer therapy and MRI. The as-prepared porous iron oxide nanoagents allow for T2-weighted MR imaging. Interestingly, we demonstrate that the porous structure endows the nanoagents an outstanding photothermal property for cancer cell killing, in comparison with other types of iron oxide nanomaterials...
February 5, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29397741/biomimetic-nanovesicles-for-enhanced-antitumor-activity-of-combinational-photothermal-and-chemotherapy
#13
Tingting Wu, Dan Zhang, Qi Qiao, Xianya Qin, Conglian Yang, Miao Kong, Huan Deng, Zhiping Zhang
Combination of multiple modalities has shown great potential in cancer treatment with improved therapeutic effects and minimized side effects. Here we fabricated a kind of doxorubicin encapsulated biomimetic nanovesicles (NVs) by a facile method with near-infrared dye insertion in the membrane for combinatorial photothermal and chemotherapy. With innate biomimetic properties, NVs enhanced the uptake by tumor cells while reduced the phagocytosis of macrophages. Upon laser irradiation, NVs can convert the absorbed fluorescent energy into heat for effective tumor killing...
February 4, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29385917/a-meta-analysis-of-outcomes-and-complications-of-magnetic-resonance-guided-focused-ultrasound-in-the-treatment-of-essential-tremor
#14
Nasser Mohammed, Devi Patra, Anil Nanda
OBJECTIVE Magnetic resonance-guided focused ultrasound (MRgFUS) is a novel technique that uses high-intensity focused ultrasound to achieve target ablation. Like a lens focusing the sun's rays, the ultrasound waves are focused to generate heat. This therapy combines the noninvasiveness of Gamma Knife thalamotomy and the real-time ablation of deep brain stimulation with acceptable complication rates. The aim of this study was to analyze the overall outcomes and complications of MRgFUS in the treatment of essential tremor (ET)...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29383144/insufficient-microwave-ablation-induced-promotion-of-distant-metastasis-is-suppressed-by-%C3%AE-catenin-pathway-inhibition-in-breast-cancer
#15
Peng Kong, Hong Pan, Muxin Yu, Lie Chen, Han Ge, Jin Zhu, Ge Ma, Li Li, Qiang Ding, Wenbin Zhou, Shui Wang
Microwave ablation (MWA), a thermal ablation, is an effective treatment for breast cancer. However, residual breast cancer is still detected. The biological characteristics of residual breast cancer after thermal ablation remain unknown. To mimic insufficient MWA in vitro, breast cancer cells were treated at 37°C, 42°C, 45°C, 47°C and 50°C for 10 mins, the 37°C as control group. Insufficient MWA induced EMT-like changes of residual breast cancer by down-regulation of E-cadherin and up-regulation of vimentin and N-cadherin in vitro and in vivo...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29382332/nanographene-oxide-methylene-blue-as-phototherapies-platform-for-breast-tumor-ablation-and-metastasis-prevention-in-a-syngeneic-orthotopic-murine-model
#16
Mayara Simonelly Costa Dos Santos, Ana Luisa Gouvêa, Ludmilla David de Moura, Leonardo Giordano Paterno, Paulo Eduardo Narcizo de Souza, Ana Paula Bastos, Emanuel Adelino Medeiros Damasceno, Fabiane Hiratsuka Veiga-Souza, Ricardo Bentes de Azevedo, Sônia Nair Báo
BACKGROUND: In the photodynamic therapy (PDT), the photosensitizer absorbs light and transfers the energy of the excited state to the oxygen in the cell environment producing reactive oxygen species (ROS), that in its turn, may cause cell damage. In the photothermal therapy (PTT), light also is responsible for activating the photothermal agent, which converts the absorbed energy in heat. Graphene oxide is a carbon-based material that presents photothermal activity. Its physical properties allow the association with the photosensitizer methylene blue and consequently the production of ROS when submitted to light irradiation...
January 30, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29374599/ph-triggered-charge-reversible-of-glycol-chitosan-conjugated-carboxyl-graphene-for-enhancing-photothermal-ablation-of-focal-infection
#17
Wei Qian, Chang Yan, Danfeng He, Yunzhou Yu, Long Yuan, Menglong Liu, Gaoxing Luo, Jun Deng
Subcutaneous abscesses infected by multidrug-resistant bacteria are becoming an increasing challenge to human health. To address this challenge, a surface-adaptive and biocompatible glycol chitosan conjugated carboxyl graphene (GCS-CG) is developed, which exhibits unique self-adaptive target to the acidic microenvironment of abscess (∼ pH 6.3) and no damage to the healthy tissue (pH 7.4) around the abscess. Originally, following conjugated with GCS, the absorbance of CG obviously increased in the near-infrared (NIR) region, enabling GCS-CG to generate an increment amount of heat...
January 24, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29350645/developments-in-the-management-of-bone-metastases-with-interventional-radiology
#18
Francesco Arrigoni, Federico Bruno, Luigi Zugaro, Raffaele Natella, Salvatore Cappabianca, Umberto Russo, Vito Roberto Papapietro, Alessandra Splendiani, Ernesto Di Cesare, Carlo Masciocchi, Antonio Barile
Interventional radiology has known an exponential growth in the last years. Technological advances of the last decades, have made it possible to use new treatments on a larger scale, with safe and effective results. They could be considered as palliative treatments for painful lesions but also curative procedures, as single treatment or specially in combination with other techniques (surgery, radiation and oncology therapies, etc.).The main diffuse techniques are those of thermal ablation that destroy the target lesion through the heat; however there are also endovascular therapies that destroy the target tissue thanks to devascularization...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29349469/dopant-dependent-crystallization-and-photothermal-effect-of-sb-doped-sno2-nanoparticles-as-stable-theranostic-nanoagents-for-tumor-ablation
#19
Nuo Yu, Chen Peng, Zhaojie Wang, Zixiao Liu, Bo Zhu, Zhigao Yi, Meifang Zhu, Xiaogang Liu, Zhigang Chen
Ideal theranostic nanoagents should be "all-in-one" type nanocrystals that have a single-semiconductor component and all-required properties (such as imaging and photothermal effects), but most semiconductor nanocrystals do not have these required properties. With SnO2 as a model of a typical wide-band semiconductor, we report the tuning from UV-responsive SnO2 to blue SnO2 nanocrystals with imaging ability and a Sb-doping-dependent photothermal effect. Sb-Doped SnO2 nanocrystals were prepared by heating SbCl3 and SnCl4 in benzyl alcohol solution through a facile solvothermal route...
January 19, 2018: Nanoscale
https://www.readbyqxmd.com/read/29347378/interfacial-mixing-in-high-energy-density-matter-with-a-multiphysics-kinetic-model
#20
Jeffrey R Haack, Cory D Hauck, Michael S Murillo
We have extended a recently developed multispecies, multitemperature Bhatnagar-Gross-Krook model [Haack et al., J. Stat. Phys. 168, 822 (2017)JSTPBS0022-471510.1007/s10955-017-1824-9], to include multiphysics capabilities that enable modeling of a wider range of physical conditions. In terms of geometry, we have extended from the spatially homogeneous setting to one spatial dimension. In terms of the physics, we have included an atomic ionization model, accurate collision physics across coupling regimes, self-consistent electric fields, and degeneracy in the electronic screening...
December 2017: Physical Review. E
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