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https://www.readbyqxmd.com/read/27916745/transcatheter-non-contact-microwave-ablation-may-enable-circumferential-renal-artery-denervation-while-sparing-the-vessel-intima-and-media
#1
Pierre C Qian, Michael A Barry, Sara Al-Raisi, Pramesh Kovoor, Jim Pouliopoulos, Chrishan Nalliah, Abhishek Bhaskaran, William Chik, Rahul Kurup, Virginia James, Winny Varikatt, Alistair McEwan, Aravinda Thiagalingam, Stuart P Thomas
AIMS: Trials of transcatheter renal artery denervation (RDN) have failed to show consistent antihypertensive efficacy. Procedural factors and limitations of radiofrequency ablation can lead to incomplete denervation. We hypothesized that non-contact microwave catheter ablation could produce deep circumferential perivascular heating while avoiding the renal artery intima and media injury. METHOD AND RESULTS: A novel microwave catheter was designed and tested in a renal artery model consisting layers of phantom materials embedded with a thermochromic liquid crystal sheet, colour range 50-78°C...
December 6, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27912130/acidity-triggered-charge-convertible-nanoparticles-that-can-cause-bacterium-specific-aggregation-in-situ-to-enhance-photothermal-ablation-of-focal-infection
#2
Chiranjeevi Korupalli, Chieh-Cheng Huang, Wei-Chih Lin, Wen-Yu Pan, Po-Yen Lin, Wei-Lin Wan, Meng-Ju Li, Yen Chang, Hsing-Wen Sung
Focal infections that are caused by antibiotic-resistant bacteria are becoming an ever-growing challenge to human health. To address this challenge, a pH-responsive amphiphilic polymer of polyaniline-conjugated glycol chitosan (PANI-GCS) that can self-assemble into nanoparticles (NPs) in situ is developed. The PANI-GCS NPs undergo a unique surface charge conversion that is induced by their local pH, favoring bacterium-specific aggregation without direct contact with host cells. Following conjugation onto GCS, the optical-absorbance peak of PANI is red-shifted toward the near-infrared (NIR) region, enabling PANI-GCS NPs to generate a substantial amount of heat, which is emitted to their neighborhood...
November 24, 2016: Biomaterials
https://www.readbyqxmd.com/read/27909522/safety-and-necessity-of-thermal-esophageal-probes-during-radiofrequency-ablation-for-the-treatment-of-atrial-fibrillation
#3
Antonio Fasano, Prof Emeritus, Luca Anfuso Md, Stefano Bozzi Md, Claudio Pandozi Prof
BACKGROUND: Radiofrequency ablation is extensively used to achieve pulmonary veins isolation for the cure of atrial fibrillation. Luminal esophageal temperature can be monitored by means of suitable probes to prevent the onset of lesions. OBJECTIVE: To compute the thermal field generated by the ablation, to investigate the interaction between the electromagnetic field and the probe sensors, and to provide a safe interpretation of the temperature detected by the probe, supported by clinical data...
June 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27892715/incorporation-of-chemotherapeutic-agent-and-photosensitizer-in-a-low-temperature-sensitive-liposome-for-effective-chemo-hyperthermic-anticancer-activity
#4
Hanh Thuy Nguyen, Tuan Hiep Tran, Raj Kumar Thapa, Tung Thanh Pham, Jee-Heon Jeong, Yu Seok Youn, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
OBJECTIVES: In this study, we combined chemo- and hyperthermia therapy in a low temperature-sensitive liposome (LTSL) for potential cancer treatment. METHODS: Docetaxel (DOC) and indocyanine green (ICG) as a therapeutic agent and photosensitizer, respectively, were incorporated in a low temperature-sensitive liposome (LTSL/DI). Nanoparticles were evaluated for the physicochemical characterizations, in vitro uptake and cytotoxicity, and furthermore in vivo anticancer activity...
November 28, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27885739/analysis-of-factors-affecting-outcome-of-ultrasound-guided-radiofrequency-heat-ablation-for-treatment-of-primary-hyperparathyroidism-in-dogs
#5
Daniel Bucy, Rachel Pollard, Richard Nelson
Radiofrequency (RF) parathyroid ablation is a noninvasive treatment for hyperparathyroidism in dogs. There are no published data assessing factors associated with RF parathyroid ablation success or failure in order to guide patient selection and improve outcome. The purpose of this retrospective analytical study was to determine whether imaging findings, biochemical data, or concurrent diseases were associated with RF heat ablation treatment failure. For inclusion in the study, dogs must have had a clinical diagnosis of primary hyperparathyroidism, undergone cervical ultrasound and RF ablation of abnormal parathyroid tissue, and must have had at least 3 months of follow-up information available following the date of ultrasound-guided parathyroid ablation...
November 24, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27882240/t2-based-temperature-monitoring-in-bone-marrow-for-mr-guided-focused-ultrasound
#6
Eugene Ozhinsky, Misung Han, Matthew Bucknor, Roland Krug, Viola Rieke
BACKGROUND: Current clinical protocols for MR-guided focused ultrasound (MRgFUS) treatment of osseous lesions, including painful bone metastases and osteoid osteomas, rely on measurement of the temperature change in adjacent muscle to estimate the temperature of the bone. The goal of this study was to determine if T2-based thermometry could be used to monitor the temperature change in bone marrow during focused ultrasound ablation of bone lesions. METHODS: We investigated the dependence of T2 on temperature in ex vivo bovine yellow bone marrow at 3T and studied the influence of acquisition parameters on the T2 measurements...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27877239/nir-laser-controlled-drug-release-from-dox-ir-780-loaded-temperature-sensitive-liposomes-for-chemo-photothermal-synergistic-tumor-therapy
#7
Fei Yan, Wanlu Duan, Yekuo Li, Hao Wu, Yuli Zhou, Min Pan, Hongmei Liu, Xin Liu, Hairong Zheng
NIR laser-induced photothermal therapy (PTT) through near-infrared agents has demonstrated the great potential in solid tumor ablation. However, the nonuniform heat distribution over tumors from PTT makes it insufficient to kill all tumor cells, resulting in tumor recurrence and inferior outcomes. To improve the tumor treatment efficacy, it is highly desirable to develop the combinational treatment of PTT with other modalities, especially with chemotherapeutic agents. Here we report a smart DOX/IR-780-loaded temperature-sensitive-liposome (DITSL) which can achieve NIR-laser-controlled drug release for chemo-photothermal synergistic tumor therapy...
2016: Theranostics
https://www.readbyqxmd.com/read/27875978/near-infrared-light-responsive-polymeric-nanocomposites-for-cancer-therapy
#8
Cong Min, Xueqing Zou, Quanzhu Yang, Liqiong Liao, Guofu Zhou, Lijian Liu
Inorganic nanoparticles, which can absorb and convert near infrared (NIR) light to heat to ablate cancer cells, have been widely investigated in photothermal therapy. However, the inherent poor solubility and acute systemic toxicity of these inorganic particles hinder their application in clinical practice. Polymeric nnanocomposites materials containing both inorganic nanoparticles and polymers could be harnessed to achieve enhanced photothermal therapeutic effect as well as improved biocompatibility and multi-responsiveness...
November 22, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27875011/characterization-of-tin-ethylene-glycol-solar-nanofluids-synthesized-by-laser
#9
Omar Torres-Mendieta, Rosa Mondragron, Verónica Puerto-Belda, Omel Mendoza-Yero, Jesús Lancis, J Enrique Bolivar, Gladys Mínguez-Vega
Solar energy is extended over wide geographical areas and is becoming an essential tool to keep the ever-increasing demand of energy with minimal environmental impact. A solar nanofluid is a novel solar receiver concept for efficient harvesting of solar radiation based on volumetric absorption of directly irradiated nanoparticles in a heat transfer fluid. Herein, the fabrication of a solar nanofluid by pulsed laser ablation in liquids was explored. This study was conducted with the ablation of bulk tin immersed in ethylene glycol with a femtosecond laser...
November 22, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27869644/hydrogen-gas-sensors-from-polysilicon-nanobelt-devices-selectively-modified-with-sensing-materials
#10
Nhan Ai Tran, Fu-Ming Pan, Jeng-Tzong Sheu
Double-junction n(+)/n(-)/n(+) polysilicon nanobelts featuring selectively deposited sensing materials have been investigated for application as H2 gas sensors. The selective modification of the devices was performed through a combination of localized ablation of a resist and lift-off of a previous catalyst material deposited through e-beam evaporation. Four nanobelt devices, differentiated by their doping concentrations at the n(-) region (from 2.5 × 10(13) to 2.5 × 10(14) cm(-2)), were analyzed in terms of the responses to H2 and their self-heating effects...
December 16, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27867681/local-ablative-treatments-for-hepatocellular-carcinoma-an-updated-review
#11
REVIEW
Antonio Facciorusso, Gaetano Serviddio, Nicola Muscatiello
Ablative treatments currently represent the first-line option for the treatment of early stage unresectable hepatocellular carcinoma (HCC). Furthermore, they are effective as bridging/downstaging therapies before orthotopic liver transplantation. Contraindications based on size, number, and location of nodules are quite variable in literature and strictly dependent on local expertise. Among ablative therapies, radiofrequency ablation (RFA) has gained a pivotal role due to its efficacy, with a reported 5-year survival rate of 40%-70%, and safety...
November 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27867582/central-airway-tumors-interventional-bronchoscopy-in-diagnosis-and-management
#12
REVIEW
Chun-Yu Lin, Fu-Tsai Chung
The diagnosis of central airway tumors is usually challenging because of the vague presentations. Advances in visualization technology in bronchoscopy aid early detection of bronchial lesion. Cryotechnology has great impact on endobronchial lesion sampling and provides better diagnostic yield. Airway tumor involvements result in significant alteration in life quality and lead to poor life expectancy. Timely and efficiently use ablation techniques by heat or cold energy provide symptoms relief for central airway obstruction...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27860435/porous-pt-nanoparticles-with-high-near-infrared-photothermal-conversion-efficiencies-for-photothermal-therapy
#13
Xiao-Ming Zhu, Hong-Ye Wan, Henglei Jia, Liang Liu, Jianfang Wang
Plasmonic nanostructures are of potential in acting as a type of optical agents for cancer photothermal therapy. To effectively function as photothermal therapy agents, plasmonic nanostructures are strongly desired to have good biocompatibility and high photothermal conversion efficiencies. In this study, poly(diallyldimethylammonium chloride)-coated porous Pt nanoparticles are synthesized for photothermal therapy. The Pt nanoparticles possess broadband near-infrared light absorption in the range from 650 to 1200 nm, therefore allowing for selecting different laser wavelengths for photothermal therapy...
November 17, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27853990/multi-parametric-study-of-temperature-and-thermal-damage-of-tumor-exposed-to-high-frequency-nanosecond-pulsed-electric-fields-based-on-finite-element-simulation
#14
Yan Mi, Shaoqin Rui, Chengxiang Li, Chenguo Yao, Jin Xu, Changhao Bian, Xuefeng Tang
High-frequency nanosecond-pulsed electric fields were recently introduced for tumor or abnormal tissue ablation to solve some problems of conventional electroporation. However, it is necessary to study the thermal effects of high-field-intensity nanosecond pulses inside tissues. The multi-parametric analysis performed here is based on a finite element model of liver tissue with a tumor that has been punctured by a pair of needle electrodes. The pulse voltage used in this study ranges from 1 to 4 kV, the pulse width ranges from 50 to 500 ns, and the repetition frequency is between 100 kHz and 1 MHz...
November 16, 2016: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/27847290/image-guided-radiofrequency-ablation-for-small-renal-masses
#15
REVIEW
Emily F Kelly, Raymond J Leveillee
The diagnosis of incidental small renal masses (SRM) has increased during the past two decades secondary to the increased use of various abdominal imaging modalities. In the past decade there has been a shift from radical nephrectomy to nephron sparing surgery techniques where partial nephrectomy has become the standard of care. Thermal ablation (TA) modalities such as freezing or heating delivered percutaneously for the treatment of small renal masses (SRM) is now offered in many Institutions as a treatment option...
November 12, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27837451/percutaneous-image-guided-cryoablation-current-applications-and-results-in-the-oncologic-field
#16
Roberto Luigi Cazzato, Julien Garnon, Nitin Ramamurthy, Guillaume Koch, Georgia Tsoumakidou, Jean Caudrelier, Francesco Arrigoni, Luigi Zugaro, Antonio Barile, Carlo Masciocchi, Afshin Gangi
Percutaneous imaging-guided cryoablation (PICA) is a recently developed technique, which applies extreme hypothermia to destroy tumours under close imaging surveillance. It is minimally invasive, safe, repeatable, and does not interrupt or compromise other oncologic therapies. It presents several advantages over more established heat-based thermal ablation techniques (e.g. radiofrequency ablation; RFA) including intrinsic analgesic properties, superior monitoring capability on multi-modal imaging, ability to treat larger tumours, and preservation of tissue collagenous architecture...
December 2016: Medical Oncology
https://www.readbyqxmd.com/read/27795996/photothermal-therapy-of-glioblastoma-multiforme-using-multiwalled-carbon-nanotubes-optimized-for-diffusion-in-extracellular-space
#17
Brittany N Eldridge, Brian W Bernish, Cale D Fahrenholtz, Ravi Singh
Glioblastoma multiforme (GBM) is the most common and most lethal primary brain tumor with a 5 year overall survival rate of approximately 5%. Currently, no therapy is curative and all have significant side effects. Focal thermal ablative therapies are being investigated as a new therapeutic approach. Such therapies can be enhanced using nanotechnology. Carbon nanotube mediated thermal therapy (CNMTT) uses lasers that emit near infrared radiation to excite carbon nanotubes (CNTs) localized to the tumor to generate heat needed for thermal ablation...
June 13, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/27795298/fabp4-ap2-regulates-macrophage-redox-signaling-and-inflammasome-activation-via-control-of-ucp2
#18
Kaylee A Steen, Hongliang Xu, David A Bernlohr
Obesity-linked metabolic disease is mechanistically associated with the accumulation of proinflammatory macrophages in adipose tissue leading to increased reactive oxygen species (ROS) production and low-grade, chronic inflammation. Previous work has demonstrated that deletion of the adipocyte fatty acid-binding protein (FABP4/aP2) uncouples obesity from inflammation via up-regulation of the uncoupling protein 2 (UCP2). Herein we demonstrate that ablation of FABP4/aP2 regulates systemic redox capacity, reduces cellular protein sulfhydryl oxidation and in particular, oxidation of mitochondrial protein cysteine residues...
October 17, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27785974/gold-nanoprism-nanorod-face-off-comparing-the-heating-efficiency-cellular-internalization-and-thermoablation-capacity
#19
Gabriel Alfranca, Álvaro Artiga, Grazyna Stepien, María Moros, Scott G Mitchell, Jesús M de la Fuente
AIM: This work compares the synthesis, heating capability, cellular internalization and thermoablation capacity of two different types of anisotropic gold nanoparticles: gold nanorods (NRs) and nanoprisms (NPrs). METHODS: Both particles possess surface plasmon resonance absorption bands in the near-IR, and their heating efficiency upon irradiation with a continuous near-IR laser (1064 nm) was evaluated. The cellular internalization, location and toxicity of these PEG-stabilized NPrs and NRs were then assessed in the Vero cell line by transmission electron microscopy and inductively coupled plasma mass spectrometry analysis, and their ability to induce cell death upon laser irradiation was then evaluated and compared...
October 27, 2016: Nanomedicine
https://www.readbyqxmd.com/read/27782630/time-resolved-study-of-laser-initiated-shock-wave-propagation-in-superfluid-4-he
#20
Allan Garcia, Xavier Buelna, Evgeny Popov, Jussi Eloranta
Intense shock waves in superfluid (4)He between 1.7 and 2.1 K are generated by rapidly expanding confined plasma from laser ablation of a metal target immersed in the liquid. The resulting shock fronts in the liquid with initial velocities up to ca. Mach 10 are visualized by time-resolved shadowgraph photography. These high intensity shocks decay within 500 ns into less energetic shock waves traveling at Mach 2, which have their lifetime in the microsecond time scale. Based on the analysis using the classical Rankine-Hugoniot theory, the shock fronts created remain in the solid phase up to 1 μs and the associated thermodynamic state appears outside the previously studied region...
September 28, 2016: Journal of Chemical Physics
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