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https://www.readbyqxmd.com/read/28814882/the-effect-of-lipiodol-deposition-in-hcc-after-tace-on-the-necrosis-range-of-pmct
#1
HongLiang Sun, JiaYan Ni, XiongYing Jiang, Dong Chen, YaoTing Chen, LinFeng Xu
OBJECTIVE: To study the impact of lipiodol deposition in the lesion of hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE) on the necrosis area of percutaneous microwave coagulation therapy (PMCT). MATERIALS AND METHODS: A total of 44 patients with HCC with 56 nodules, with a size ranging from 1.5 to 3.5 cm, was selected in our study. About 23 patients (26 nodules) underwent PMCT treatment only as Group A and 21 patients (30 nodules) were treated by PMCT-combined TACE as Group B...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28803873/neural-circuitry-that-evokes-escape-behavior-upon-activation-of-nociceptive-sensory-neurons-in-drosophila-larvae
#2
Jiro Yoshino, Rei K Morikawa, Eri Hasegawa, Kazuo Emoto
Noxious stimuli trigger a stereotyped escape response in animals. In Drosophila larvae, class IV dendrite arborization (C4 da) sensory neurons in the peripheral nervous system are responsible for perception of multiple nociceptive modalities, including noxious heat and harsh mechanical stimulation, through distinct receptors [1-9]. Silencing or ablation of C4 da neurons largely eliminates larval responses to noxious stimuli [10-12], whereas optogenetic activation of C4 da neurons is sufficient to provoke corkscrew-like rolling behavior similar to what is observed when larvae receive noxious stimuli, such as high temperature or harsh mechanical stimulation [10-12]...
August 4, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28799842/midterm-safety-and-efficacy-of-irreversible-electroporation-of-malignant-liver-tumors-located-close-to-major-portal-or-hepatic-veins
#3
Martina Distelmaier, Alexandra Barabasch, Philipp Heil, Nils A Kraemer, Peter Isfort, Sebastian Keil, Christiane K Kuhl, Philipp Bruners
Purpose To investigate the efficacy and safety of irreversible electroporation (IRE) in the treatment of hepatic tumors not suitable for thermal ablation (radiofrequency ablation [RFA] or microwave ablation). Materials and Methods This was an institutional review board-approved prospective study in 29 patients (15 men, 14 women; mean age, 63 years ± 12 [standard deviation]) with 43 primary (n = 8) or secondary (n = 35) malignant liver tumors who underwent computed tomography (CT)-guided IRE. All target tumors were located immediately adjacent to major hepatic veins, portal veins, or both; thus, they were not considered suitable for RFA or microwave ablation...
August 11, 2017: Radiology
https://www.readbyqxmd.com/read/28795419/simultaneous-mr-thermometry-and-acoustic-radiation-force-imaging-using-interleaved-acquisition
#4
Joshua T de Bever, Henrik Odéen, Lorne W Hofstetter, Dennis L Parker
PURPOSE: A novel and practical method for simultaneously performing MR acoustic radiation force imaging (ARFI) and proton resonance frequency (PRF)-shift thermometry has been developed and tested. This could be an important tool for evaluating the success of MR-guided focused ultrasound procedures for which MR-thermometry measures temperature and thermal dose and MR-ARFI detects changes in tissue mechanical properties. METHODS: MR imaging was performed using a gradient recalled echo segmented echo-planar imaging pulse sequence with bipolar motion encoding gradients (MEG)...
August 10, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28783035/combined-photothermal-chemotherapy-of-breast-cancer-by-near-infrared-light-responsive-hyaluronic-acid-decorated-nanostructured-lipid-carriers
#5
Shaohui Zheng, VAN DU Nguyen, Seung Yoon Song, Jiwon Han, Jong-Oh Park
In this study, a novel type of hyaluronic acid (HA)-decorated nanostructured lipid carrier (NLC) was prepared and investigated as a light-triggered drug release and combined photothermal-chemotherapy for cancer treatment. Polyhedral gold nanoparticles (Au NPs) with an average size of 10 nm were synthesized and co-encapsulated with doxorubicin (DOX) in the matrix of NLCs with a high drug loading efficiency (above 80%). HA decoration was achieved by the electrostatic interaction between HA and CTAB on the NLCs surface...
August 7, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28774822/browning-deficiency-and-low-mobilization-of-fatty-acids-in-gonadal-white-adipose-tissue-leads-to-decreased-cold-tolerance-of-transglutaminase-2-knock-out-mice
#6
András Mádi, Ixchelt Cuaranta-Monroy, Kinga Lénárt, Attila Pap, Zoltán András Mezei, Endre Kristóf, Anna Oláh, György Vámosi, Zsolt Bacsó, Péter Bai, László Fésüs
During cold-exposure 'beige' adipocytes with increased mitochondrial content are activated in white adipose tissue (WAT). These cells, similarly to brown adipocytes (BAT), dissipate stored chemical energy in the form of heat with the help of uncoupling protein 1 (UCP1). We investigated the effect of TG2 ablation on the function of ATs in mice. Although TG2(+/+) and TG2(-/-) mice had the same amount of WAT and BAT, we found that TG2(+/+) animals could tolerate acute cold exposure for 4h, whereas TG2(-/-) mice only for 3h...
July 31, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28774708/epileptologist-s-view-laser-interstitial-thermal-ablation-for-treatment-of-temporal-lobe-epilepsy
#7
Joon Y Kang, Michael R Sperling
A procedure called laser interstitial thermal ablation has been utilized to treat drug resistant epilepsy. With this technique, a probe is stereotactically inserted into a target structure responsible for seizures, such as mesial temporal lobe, hypothalamic hamartoma, or a small malformation of cortical development, and the tip is then heated by application of laser energy to ablate structures adjacent to the probe tip. This procedure has the advantage of selectively targeting small lesions responsible for seizures, and is far less invasive than open surgery with shorter hospitalization, less pain, and rapid return to normal activities...
July 25, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28773846/improved-ablation-resistance-of-silicone-rubber-composites-by-introducing-montmorillonite-and-silicon-carbide-whisker
#8
Guangwu Zhang, Fuzhong Wang, Zhixiong Huang, Jing Dai, Minxian Shi
Montmorillonite (MMT) was added to silicone rubber (SR) to improve the ablation resistance of the silicone. Following this, different quantities of silicon carbide whiskers (SiCw) were incorporated into the MMT/SR to yield a hybrid, ablative composite. The tensile strength and elongation at break of the composite increased after the addition of MMT. The ablation test results showed that MMT helped to form a covering layer by bonding with the silica and other components on the ablated surface. The linear and mass ablation rates exhibited decreases of 22...
August 24, 2016: Materials
https://www.readbyqxmd.com/read/28769092/unprecedented-heat-wave-in-december-2015-and-potential-for-winter-glacier-ablation-in-the-eastern-alps
#9
Renato R Colucci, Filippo Giorgi, Csaba Torma
We document the occurrence in December 2015 of unprecedented high monthly mean temperatures in the observational record of mountain sites in the eastern Alps. For the first time in the last 150 years mean December temperature exceeded 0 °C at elevations between 2100 and 2500 m, with December mean anomalies exceeding 6.5 °C with respect to the 1971-2000 mean. Along with the absence of snow cover, such temperatures might have lead to unprecedented winter ablation of glaciers in this elevation range. Smaller temperature anomalies occurred in surrounding low elevation sites, highlighting the key role of topography in this event...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28754659/stress-induced-sleep-after-exposure-to-ultraviolet-light-is-promoted-by-p53-in-caenorhabditis-elegans
#10
Hilary DeBardeleben, Lindsey E Lopes, Mark P Nessel, David M Raizen
Stress-induced sleep (SIS) in C. elegans is important for restoration of cellular homeostasis and is a useful model to study the function and regulation of sleep. SIS is triggered when epidermal growth factor (EGF) activates the ALA neuron, which then releases neuropeptides to promote sleep. To further understand this behavior, we established a new model of stress-induced sleep using irradiation by ultraviolet C (UVC) light. While UVC irradiation requires ALA signaling and leads to a sleep state similar to that induced by heat and other stressors, it does not induce the proteostatic stress seen with heat exposure...
July 28, 2017: Genetics
https://www.readbyqxmd.com/read/28750317/advantages-of-cooled-fiber-for-monitoring-laser-tissue-ablation-through-temporal-and-spectral-analysis-of-rf-ultrasound-signal-a-case-study
#11
Simona Granchi, Enrico Vannacci, Luca Breschi, Elena Biagi
The promising minimally invasive laser thermal therapy technique may be improved if thermal lesions induced into the tissue can be carefully monitored in extension and morphology during the treatment. According to results obtained in several recent experimentations, solutions that avoid tissue carbonization during the treatment have been proposed, in order to allow deeper and longer lasting light penetration in treated tissue and to reduce failures of the applicator tip and fiber optic, dangerous for patients...
July 19, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28741635/liposomes-loading-sodium-chloride-as-effective-thermo-seeds-for-microwave-ablation-of-hepatocellular-carcinoma
#12
Qunfang Zhou, Songsong Wu, Ningqiang Gong, Xin Li, Jianping Dou, Mengjuan Mu, Xiaoling Yu, Jie Yu, Ping Liang
Microwave ablation (MWA) is a promising minimally invasive therapy that has been widely used to treat hepatocellular carcinoma (HCC). However, the efficiency of MWA in treating HCC is evidently limited by the incomplete ablation of large tumors and tumors in high-risk locations. Here, we report the value of using liposomes packed with sodium chloride (NaCl-LPs) as effective thermo-seeds for MWA of HCC. The prepared liposomes exhibited excellent heat conversion ability by showing a more rapid temperature increase than free NaCl medium, blank liposomes or water under microwave irradiation...
July 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28732507/long-noncoding-rna-expression-profiles-in-sub-lethal-heat-treated-hepatoma-carcinoma-cells
#13
Qingsong Deng, Shihan Chen, Chunchuan Fu, Jiayun Jiang, Mengda Zou, Yunhua Tan, Xiaofei Wang, Feng Xia, Kai Feng, Kuansheng Ma, Ping Bie
BACKGROUND: Sub-lethal heat treatment characterizes a transition zone of radiofrequency ablation (RFA) which explains hepatocellular carcinoma (HCC) residual cancer occurrence in this area after RFA treatment. The biochemistry of residual cancer cell recurrence is poorly understood, but long noncoding RNAs (lncRNAs) may have aberrant expression that is associated with diverse cancers. Thus, we measured lncRNA gene expression in sub-lethally heat-treated HCC cells using microarray. METHOD: Differentially expressed lncRNA and mRNA were measured with an Agilent Human lncRNA + mRNA Array V4...
July 21, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28731366/chondromyxoid-fibroma-of-the-distal-fibula-treated-by-percutaneous-radiofrequency-ablation
#14
Tamar Berenstein-Weyel, Ehud Lebel, Daniela Katz, Yaakov Applbaum, Amos Peyser
BACKGROUND: Percutaneous radiofrequency ablation (RFA) has been shown to be an effective treatment for soft tissue lesions and also benign bone tumors, especially osteoid osteoma. There are limited data regarding this technique in other bone tumors, specifically larger and more aggressive ones. PURPOSES: To describe the use of RFA as a definitive treatment and an alternative to traditional open surgery for the treatment of chondromyxoid fibroma (CMF), a benign but locally aggressive bone tumor...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28721452/enhanced-efficacy-of-radiofrequency-ablation-for-hepatocellular-carcinoma-using-a-novel-vascular-disrupting-agent-ckd-516
#15
Su Jung Ham, YoonSeok Choi, Seul-I Lee, Jinil Kim, Young Il Kim, Jin Wook Chung, Kyung Won Kim
BACKGROUND: CKD-516 is a novel vascular disrupting agent that shuts down intratumoral blood flow. We therefore hypothesized that concomitant administration of CKD-516 would enhance the therapeutic efficacy of radiofrequency ablation (RFA) by reducing heat sink effects. We assessed the effects of the combination of CKD-516 and RFA in a rat orthotopic hepatocellular carcinoma (HCC) model. METHODS: Rat HCC cells (N1-S1) were engrafted into the hepatic lobe of Sprague-Dawley (SD) rats...
July 18, 2017: Hepatology International
https://www.readbyqxmd.com/read/28720001/differential-effects-of-heat-stress-on-fibre-capillarisation-in-tenotomised-soleus-and-plantaris-muscles
#16
Muthita Hirunsai, Ratchakrit Srikuea
PURPOSE: Capillary regression is commonly observed in response to disuse muscle atrophy. Heat stress is known to alleviate muscle atrophy, while effect of heat exposure on capillary adaptation following disuse atrophy is not defined. Here, we examined the effect of heat treatment on capillarisation and the associated signalling in slow-oxidative soleus and fast-glycolytic plantaris muscles following Achilles tendon ablation (tenotomy). MATERIALS AND METHODS: Male Wistar rats were assigned into control (CON), control with heat stress (CON + HEAT), tenotomy (TEN) and tenotomy with heat stress (TEN + HEAT) groups...
July 18, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28715202/antifouling-biomimetic-liquid-infused-stainless-steel-application-to-dairy-industrial-processing
#17
Sawsen Zouaghi, Thierry Six, Séverine Bellayer, Sona Moradi, Savvas G Hatzikiriakos, Thomas Dargent, Vincent Thomy, Yannick Coffinier, Christophe André, Guillaume Delaplace, Maude Jimenez
Fouling is a widespread and costly issue, faced by all food-processing industries. Particularly, in the dairy sector, where thermal treatments are mandatory to ensure product safety, heat-induced fouling represents up to 80% of the total production costs. Significant environmental impacts, due the massive consumption of water and energy, are also to deplore. Fouling control solutions are thus desperately needed, as they would lead to substantial financial gains as well as tremendous progress toward eco-responsible processes...
August 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28715071/the-influence-of-ablation-power-reduction-associated-with-esophagus-location-on-pulmonary-veins-isolation-results-in-patients-with-paroxysmal-atrial-fibrillation-six-month-follow-up
#18
Piotr Buchta, Krzysztof Myrda, Michał Skrzypek, Adam Wojtaszczyk, Barbara Budzyn, Mariusz Gąsior
BACKGROUND: Catheter ablation of atrial fibrillation (AF) could be associated with a thermal esophageal (EO) injury. To avoid this complication intraluminal esophageal temperature monitoring and ablation power reduction at the areas with excessive heating could be used. However, the reduced energy could limit the ablation lesion depth, without creation of consist transmural scar and influence on long-term ablation results. AIM: The primary goal was to evaluate the homogeneity of forced ablation power reduction due to excessive EO heating in different parts of left atrium...
July 17, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28713631/percutaneous-cervical-laser-diskectomy-thermoannuloplasty-and-thermonucleoplasty-comparable-results-without-surgery
#19
EDITORIAL
Nancy E Epstein
BACKGROUND: Utilizing the literature, the results of three different minimally invasive surgery (MIS) anterior cervical percutaneous operations for neck/mild radicular pain and magnetic resonance (MR)-documented "contained" (not extruded/sequestrated) discs were evaluated. Results were compared with patients treated nonsurgically for comparable/greater neurological compromise, and even more severe cervical disc disease. METHODS: There were three MIS percutaneous anterior cervical discectomy procedures...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28712919/an-innovative-mwcnts-dox-tc-nanosystem-for-chemo-photothermal-combination-therapy-of-cancer
#20
Xia Dong, Zhiting Sun, Xiaoxiao Wang, Xigang Leng
Chemotherapy and photothermal therapy can be efficiently integrated to achieve enhanced antitumor efficacy by using carbon nanotubes (CNTs) which are super in delivering drug and converting near infrared radiation (NIR) into heat. We previously developed an innovative TAT-chitosan functionalized MWCNTs (MWCNTs/TC) based drug delivery system for doxorubicin (DOX) and preliminarily investigated its release profile and antitumor effect. In the present study, the application potential of MWCNTs/DOX/TC in chemo-photothermal combination therapy was further explored...
July 13, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
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