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https://www.readbyqxmd.com/read/28214487/radiofrequency-ablation-with-concomitant-stab-phlebectomy-increases-risk-of-endovenous-heat-induced-thrombosis
#1
Caitlin W Hicks, Sandra R DiBrito, J Trent Magruder, M Libby Weaver, Cathy Barenski, Jennifer A Heller
OBJECTIVE: Endovenous heat-induced thrombosis (EHIT) is a well-documented phenomenon that follows endovenous ablation, but the treatment, surveillance, and risk factors for EHIT have yet to be comprehensively elucidated. We sought to identify characteristics that may put patients at higher risk for development of EHIT after radiofrequency ablation (RFA) for the treatment of symptomatic superficial venous insufficiency. METHODS: A retrospective review was performed of all consecutive patients undergoing treatment with RFA to the great saphenous vein by a single surgeon from July 2013 through October 2015...
March 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28213926/association-of-hypercalcemia-before-treatment-with-hypocalcemia-after-treated-in-dogs-with-primary-hyperparathyroidism
#2
J D Dear, P H Kass, A M Della Maggiore, E C Feldman
BACKGROUND: Development of hypocalcemia after treatment of hyperparathyroidism results in increased costs and risk of poorer outcomes. Previous studies have shown conflicting data about predictors of hypocalcemia after these procedures. HYPOTHESIS/OBJECTIVES: The objective of this study was to investigate whether ionized calcium (iCa) concentrations before treatment are predictive of hypocalcemia or its clinical signs after surgical removal or heat ablation in dogs with primary hyperparathyroidism...
February 18, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28204456/the-relationship-between-oesophageal-heating-during-left-atrial-posterior-wall-ablation-and-the-durability-of-pulmonary-vein-isolation
#3
V Nam Tran, Shigeki Kusa, Jeffrey Smietana, Wen-Chi Tsai, Kabir Bhasin, Andrew Teh, George Syros, Anurag Singh, Subbaro Choudry, Marc A Miller, Jacob Koruth, Andre D'Avila, Srinivas D Dukkipati, Vivek Y Reddy
No abstract text is available yet for this article.
February 15, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28185304/dual-echo-z-shimmed-proton-resonance-frequency-shift-magnetic-resonance-thermometry-near-metallic-ablation-probes-technique-and-temperature-precision
#4
Yuxin Zhang, Megan E Poorman, William A Grissom
PURPOSE: To improve the precision of proton resonance frequency-shift magnetic resonance thermometry near ablation probes by recovering near-probe image signals that are typically lost due to magnetic susceptibility-induced field distortions. METHODS: A dual-echo gradient-recalled echo sequence was implemented, in which the first echo was under- or over-refocused in the slice dimension to recover image signal and temperature precision near a probe, and the second echo was fully refocused to obtain image signal everywhere else in the slice...
February 10, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28182306/effect-of-a-hypoxic-microenvironment-after-radiofrequency-ablation-on-residual-hepatocellular-cell-migration-and-invasion
#5
Yuyang Tong, Haiyun Yang, Xiaolin Xu, Jingliang Ruan, Ming Liang, Jiayi Wu, Baoming Luo
Clinical observations have shown that the boundary of tumor ablation is often less than safe border and that the use of radiofrequency ablation (RFA) in the treatment of hepatocellular carcinoma (HCC) may probably accelerate its recurrence and metastasis. RFA can cause the formation of a transition zone between normal liver tissues and necrotic coagulation, where blood stagnation and thrombosis expose residual cancer cells to a hypoxic microenvironment. As the blocked vessels are slowly reperfused, the oxygen supply is gradually restored...
February 9, 2017: Cancer Science
https://www.readbyqxmd.com/read/28167318/temperature-monitoring-by-channel-data-delays-feasibility-based-on-estimated-delays-magnitude-for-cardiac-ablation
#6
Margot Pasternak, Eigil Samset, Jan D'hooge, Geir U Haugen
Ultrasound thermometry is based on measuring tissue temperature by its impact on ultrasound wave propagation. This study focuses on the use of transducer array channel data (not beamformed) and examines how a layer of increased velocity (heat induced) affects the travel-times of the ultrasound backscatter signal. Based on geometric considerations, a new equation was derived for the change in time delay as a function of temperature change. The resulting expression provides insight into the key factors that link change in temperature to change in travel time...
January 16, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28155684/the-comparison-of-lesion-outline-and-temperature-field-determined-by-different-ways-in-atrial-radiofrequency-ablation
#7
Zhen Tian, Qun Nan, Xiaohui Nie, Tong Dong, Ruirui Wang
BACKGROUND: The aim of this study is to research the lesion outline and temperature field in different ways in atrial radiofrequency ablation by using finite element method. METHODS: This study used the method which considered the thermal dosage to determine the boundary between viable and dead tissue, and compared to the 50 °C isotherm results in analyzing lesion outline. Besides, we used Hyperbolic equation which considered the relaxation time to calculate the temperature field and contrasted it with Pennes' bioheat transfer equation...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28151729/numerical-simulation-of-microwave-ablation-incorporating-tissue-contraction-based-on-thermal-dose
#8
Dong Liu, Christopher L Brace
Tissue contraction plays an important role during high temperature tumor ablation, particularly during device characterization, treatment planning and imaging follow up. We measured such contraction in 18 ex vivo bovine liver samples during microwave ablation by tracking fiducial motion on CT imaging. Contraction was then described using a thermal dose dependent model and a negative thermal expansion coefficient based on the empirical data. FEM simulations with integrated electromagnetic wave propagation, heat transfer, and structural mechanics were evaluated using temperature-dependent dielectric properties and the negative thermal expansion models...
February 2, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28146314/how-coagulation-zone-size-is-underestimated-in-computer-modeling-of-rf-ablation-by-ignoring-the-cooling-phase-just-after-rf-power-is-switched-off
#9
Ramiro M Irastorza, Macarena Trujillo, Enrique Berjano
All the numerical models developed for radiofrequency (RF) ablation so far have ignored the possible effect of the cooling phase (just after RF power is switched off) on the dimensions of the coagulation zone. Our objective was thus to quantify the differences in the minor radius of the coagulation zone computed by including and ignoring the cooling phase. We built models of RF tumor ablation with two needle-like electrodes: a dry electrode (5 mm long and 17G in diameter) with a constant temperature protocol (70 °C) and a cooled electrode (30 mm long and 17G in diameter) with a protocol of impedance control...
February 1, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28127181/non-surgical-ablative-therapy-for-management-of-small-renal-masses-current-status-and-future-trends
#10
REVIEW
K Farrag, S Sriprasad
A large number of small renal masses (SRMs) with size less than 4 cm are being identified due to advances in diagnostic imaging. As the natural history of these tumours remains unknown, there is no reliable way to predict their behaviour or future growth. Although, partial nephrectomy is the gold standard for treatment of these tumours, ablative non-surgical therapies such as cryoablation and radiofrequency ablation provide a less invasive option of treatment with comparable oncological outcomes. In this systematic review, the principle, indications, methods of treatment, oncological control, complication and renal function of ablative therapies are critically reviewed...
March 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28122204/to-heat-or-not-to-heat-challenges-with-clinical-translation-of-thermosensitive-liposomes
#11
REVIEW
Yannan Dou, Kullervo Hynynen, Christine Allen
Thermosensitive liposomes have been put forward as a strategy to improve upon the limited tumor drug availability associated with conventional non-thermosensitive liposomes. ThermoDox® is the first and only thermosensitive liposome formulation to reach clinical development. The initial Phase III clinical trial on ThermoDox® (i.e. HEAT trial) evaluating the combination of ThermoDox® and radiofrequency ablation (RFA) in comparison to RFA alone for treatment of inoperable hepatocellular carcinoma (HCC) failed to reach its primary endpoint in progression-free survival (PFS)...
January 22, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28117172/skin-vaccination-via-fractional-infrared-laser-ablation-optimization-of-laser-parameters-and-adjuvantation
#12
Sandra Scheiblhofer, Anna Strobl, Veronika Hoepflinger, Theresa Thalhamer, Martin Steiner, Josef Thalhamer, Richard Weiss
BACKGROUND: Methods to deliver an antigen into the skin in a painless, defined, and reproducible manner are essential for transcutaneous immunization (TCI). Here, we employed an ablative fractional infrared laser (P.L.E.A.S.E. Professional) to introduce clinically relevant vaccines into the skin. To elicit the highest possible antibody titers with this system, we optimized different laser parameters, such as fluence and pore number per area, and tested various adjuvants. METHODS: BALB/c mice were immunized with Hepatitis B surface antigen (HBsAg) by laser-microporation...
January 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28114383/immunogenicity-of-isogenic-igg-in-aggregates-and-immune-complexes
#13
J Benjamin St Clair, Thiago Detanico, Katja Aviszus, Greg A Kirchenbaum, Merry Christie, John F Carpenter, Lawrence J Wysocki
A paradox in monoclonal antibody (mAb) therapy is that despite the well-documented tolerogenic properties of deaggregated IgG, most therapeutic IgG mAb induce anti-mAb responses. To analyze CD4 T cell reactions against IgG in various physical states, we developed an adoptive transfer model using CD4+ T cells specific for a Vκ region-derived peptide in the hapten-specific IgG mAb 36-71. We found that heat-aggregated or immune complexes (IC) of mAb 36-71 elicited anti-idiotypic (anti-Id) antibodies, while the deaggregated form was tolerogenic...
2017: PloS One
https://www.readbyqxmd.com/read/28114116/combination-of-principal-component-analysis-and-optical-flow-motion-compensation-for-improved-cardiac-mr-thermometry
#14
S Toupin, B Denis de Senneville, V Ozenne, P Bour, M Lepetit-Coiffe, M Boissenin, P Jais, B Quesson
The use of magnetic resonance (MR) thermometry for the monitoring of thermal ablation is rapidly expanding. However, this technique remains challenging for the monitoring of the treatment of cardiac arrhythmia by radiofrequency ablation due to the heart displacement with respiration and contraction. Recent studies have addressed this problem by compensating in-plane motion in real-time with optical-flow based tracking technique. However, these algorithms are sensitive to local variation of signal intensity on magnitude images associated with tissue heating...
February 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28113196/an-electrochemistry-study-of-cryoelectrolysis-in-frozen-physiological-saline
#15
Thomas Manuel, Pujita Munnangi, Boris Rubinsky
Cryoelectrolysis is a new minimally invasive tissue ablation surgical technique that combines the processes of electrolysis and solid/liquid phase transformation (freezing). This study investigated this new technique by measuring the pH front propagation and the changes in resistance in a tissue simulant made of physiological saline gel with a pH dye as a function of the sample temperature in the high subzero range above the eutectic. Results demonstrated that effective electrolysis can occur in a high subzero freezing milieu and that the propagation of the pH front is only weakly dependent on temperature...
December 15, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28103663/biological-photothermal-nanodots-based-on-self-assembly-of-peptide-porphyrin-conjugates-for-antitumor-therapy
#16
Qianli Zou, Manzar Abbas, Luyang Zhao, Shukun Li, Guizhi Shen, Xuehai Yan
Photothermal agents can harvest light energy and convert it into heat, offering a targeted and remote-controlled way to destroy carcinomatous cells and tissues. Inspired by the biological organization of polypeptides and porphyrins in living systems, here we have developed a supramolecular strategy to fabricate photothermal nanodots through peptide-modulated self-assembly of photoactive porphyrins. The self-assembling nature of porphyrins induces the formation of J-aggregates as substructures of the nanodots, and thus enables the fabrication of nanodots with totally inhibited fluorescence emission and singlet oxygen production, leading to a high light-to-heat conversion efficiency of the nanodots...
January 30, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28098184/infrared-laser-induced-gene-expression-for-tracking-development-and-function-of-single-c-elegans-embryonic-neurons
#17
Anupriya Singhal, Shai Shaham
Visualizing neural-circuit assembly in vivo requires tracking growth of optically resolvable neurites. The Caenorhabditis elegans embryonic nervous system, comprising 222 neurons and 56 glia, is attractive for comprehensive studies of development; however, embryonic reporters are broadly expressed, making single-neurite tracking/manipulation challenging. We present a method, using an infrared laser, for reproducible heat-dependent gene expression in small sublineages (one to four cells) without radiation damage...
January 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28097603/comprehensive-preclinical-evaluation-of-a-multi-physics-model-of-liver-tumor-radiofrequency-ablation
#18
Chloé Audigier, Tommaso Mansi, Hervé Delingette, Saikiran Rapaka, Tiziano Passerini, Viorel Mihalef, Marie-Pierre Jolly, Raoul Pop, Michele Diana, Luc Soler, Ali Kamen, Dorin Comaniciu, Nicholas Ayache
PURPOSE: We aim at developing a framework for the validation of a subject-specific multi-physics model of liver tumor radiofrequency ablation (RFA). METHODS: The RFA computation becomes subject specific after several levels of personalization: geometrical and biophysical (hemodynamics, heat transfer and an extended cellular necrosis model). We present a comprehensive experimental setup combining multimodal, pre- and postoperative anatomical and functional images, as well as the interventional monitoring of intra-operative signals: the temperature and delivered power...
January 17, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28096667/hyaluronan-modified-superparamagnetic-iron-oxide-nanoparticles-for-bimodal-breast-cancer-imaging-and-photothermal-therapy
#19
Rui-Meng Yang, Chao-Ping Fu, Jin-Zhi Fang, Xiang-Dong Xu, Xin-Hua Wei, Wen-Jie Tang, Xin-Qing Jiang, Li-Ming Zhang
Theranostic nanoparticles with both imaging and therapeutic abilities are highly promising in successful diagnosis and treatment of the most devastating cancers. In this study, the dual-modal imaging and photothermal effect of hyaluronan (HA)-modified superparamagnetic iron oxide nanoparticles (HA-SPIONs), which was developed in a previous study, were investigated for CD44 HA receptor-overexpressing breast cancer in both in vitro and in vivo experiments. Heat is found to be rapidly generated by near-infrared laser range irradiation of HA-SPIONs...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28095539/a-proposed-method-for-upper-eyelid-and-infrabrow-tightening-using-a-transcutaneous-temperature-controlled-radiofrequency-device-with-opaque-plastic-eye-shields
#20
Douglas J Key, Lauren Boudreaux
BACKGROUND: Laxity of the eyelid and periorbital area, a common manifestation of aging, is usually addressed via blepharoplasty and/ or fat transfer. Given the trend toward safer, less invasive treatments preferred by those patients reticent to undergo more invasive procedures, viable alternatives have been sought. Transcutaneous temperature controlled radiofrequency (TTCRF) integrates non- invasive super cial RF treatment with automatic temperature feedback control of energy deposition, as a stimulator of overall collagen remodeling; however, the globe of the eye is particularly sensitive to RF energy...
November 1, 2016: Journal of Drugs in Dermatology: JDD
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