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https://www.readbyqxmd.com/read/28056806/suppression-of-experimental-autoimmune-encephalomyelitis-by-ultraviolet-light-is-not-mediated-by-isomerization-of-urocanic-acid
#1
Amy A Irving, Steven J Marling, Lori A Plum, Hector F DeLuca
BACKGROUND: Ultraviolet B irradiation confers strong resistance against experimental autoimmune encephalomyelitis, a model of multiple sclerosis. This protection by ultraviolet B is independent of vitamin D production but causes isomerization of urocanic acid, a naturally occurring immunosuppressant. METHODS: To determine whether UCA isomerization from trans to cis is responsible for the protection against experimental autoimmune encephalomyelitis afforded by ultraviolet B, trans- or cis-urocanic acid was administered to animals and their disease progression was monitored...
January 5, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28055026/anterior-uterocervical-angle-measurement-improves-prediction-of-cerclage-failure
#2
J C Knight, E Tenbrink, J Sheng, A S Patil
OBJECTIVE: To compare the anterior uterocervical angle and cervical length as predictors of spontaneous preterm delivery in patients with transvaginal cerclage. STUDY DESIGN: We retrospectively evaluated a cohort of 142 pregnant women with transvaginal cerclage placed over a 5-year period (2010 to 2015) were evaluated. Cervical morphology characteristics were measured from endovaginal imaging, including cervical length, cerclage height, funnel volume and anterior uterocervical angle prior to cerclage placement (UCA 1), shortly after cerclage placement (UCA 2) and the last image prior to delivery (UCA 3)...
January 5, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28052386/ecosystem-engineers-drive-creek-formation-in-salt-marshes
#3
Huy D Vu, Kazimierz Wie Ski, Steven C Pennings
Ecosystem engineers affect different organisms and processes in multiple ways at different spatial scales. Moreover, similar species may differ in their engineering effects for reasons that are not always clear. We examined the role of four species of burrowing crabs (Sesarma reticulatum, Eurytium limosum, Panopeus herbstii, Uca pugnax) in engineering tidal creek networks in salt marshes experiencing sea level rise. In the field, crab burrows were associated with heads of eroding creeks and the loss of plant (Spartina alterniflora) stems...
January 2017: Ecology
https://www.readbyqxmd.com/read/28050135/the-risk-of-colorectal-cancer-is-not-increased-after-a-diagnosis-of-urothelial-cancer-a-population-based-study
#4
C H Harlos, H Singh, Z Nugent, A Demers, S M Mahmud, P M Czaykowski
BACKGROUND: The data about whether patients with a prior urothelial cancer (uca) are at increased risk of colorectal cancer (crc) are conflicting. We used a competing risks analysis to determine the risk of crc after uca. METHODS: Historical cohorts were assembled by record linkage of Manitoba Cancer Registry and Manitoba Health databases. The incidence of crc for individuals with uca as their first cancer between 1987 and 2009 was compared with the incidence for randomly selected age-and sex-matched individuals without a cancer diagnosis at the index date (uca diagnosis date)...
December 2016: Current Oncology
https://www.readbyqxmd.com/read/28044473/synthesis-characterization-and-in-vitro-evaluation-of-targeted-gold-nanoshelled-poly-d-l-lactide-co-glycolide-nanoparticles-carrying-anti-p53-antibody-as-a-theranostic-agent-for-ultrasound-contrast-imaging-and-photothermal-therapy
#5
Li Xu, Caifeng Wan, Jing Du, Hongli Li, Xuesong Liu, Hong Yang, Fenghua Li
Breast cancer is the leading cause of cancer-related deaths in women and earlier detection can substantially reduce deaths from breast cancer. Polymers with targeted ligands are widely used in the field of molecular ultrasound imaging and targeted tumor therapy. In our study, the nanotheranostic agent was fabricated through filling perfluoropropane (C3F8) into poly(d,l-lactic-co-glycolic acid) nanoparticles (PLGA NPs), followed by the formation of gold nanoshell on the surface, then conjugated with anti p53 antibody which has high specificity with the p53 protein overexpressing in breast cancer...
January 16, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28000971/safety-and-tolerability-of-sonovue%C3%A2-in-patients-with-large-artery-anterior-circulation-acute-stroke
#6
Claudio Baracchini, Federica Viaro, Silvia Favaretto, Anna Palmieri, Caterina Kulyk, Francesco Causin, Filippo Farina, Enzo Ballotta
BACKGROUND AND PURPOSE: Ultrasound contrast agents (UCAs) are routinely used to improve the visualization of intracranial arteries. Since a higher rate of intracranial hemorrhage (ICH) has been observed in patients undergoing sonothrombolysis in combination with UCAs, we conducted this study with the aim of assessing safety and tolerability of SonoVue® in patients with acute ischemic stroke due to anterior circulation large artery occlusion (LAO) and eligible to intravenous thrombolysis and/or mechanical thrombectomy...
December 21, 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/27990422/premature-destruction-of-microbubbles-during-voiding-urosonography-in-children-and-possible-underlying-mechanisms-post-hoc-analysis-from-the-prospective-study
#7
Maciej Piskunowicz, Dominik Swieton, Dorota Rybczynska, Arkadiusz Szarmach, Edyta Szurowska, Menno Pruijm
The aim of this study is to describe premature microbubbles destruction with contrast-enhanced voiding urosonography (ce-VUS) in children using 2nd-generation ultrasound contrast agents (UCA) and to hypothesize about the reason. 141 children (61 females and 80 males) were included in the study, with mean age of 3.3 years (range 4 weeks-16.0 years), who underwent ce-VUS examination between 2011 and 2014. Premature destruction of the microbubbles in the urinary bladder during ce-VUS was observed in 11 children (7...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27916815/changes-in-biochemical-parameters-of-the-calcium-phosphorus-homeostasis-in-relation-to-nutritional-intake-in-very-low-birth-weight-infants
#8
Viola Christmann, Charlotte J W Gradussen, Michelle N Körnmann, Nel Roeleveld, Johannes B van Goudoever, Arno F J van Heijst
Preterm infants are at significant risk to develop reduced bone mineralization based on inadequate supply of calcium and phosphorus (Ca-P). Biochemical parameters can be used to evaluate the nutritional intake. The direct effect of nutritional intake on changes in biochemical parameters has not been studied. Our objective was to evaluate the effect of Ca-P supplementation on biochemical markers as serum (s)/urinary (u) Ca and P; alkaline phosphatase (ALP); tubular reabsorption of P (TrP); and urinary ratios for Ca/creatinin (creat) and P/creatinin in Very-Low-Birth-Weight infants on Postnatal Days 1, 3, 5, 7, 10, and 14...
November 29, 2016: Nutrients
https://www.readbyqxmd.com/read/27914983/neuropeptide-y-y1-receptor-mediated-biodegradable-photoluminescent-nanobubbles-as-ultrasound-contrast-agents-for-targeted-breast-cancer-imaging
#9
Juan Li, Yuchen Tian, Dingying Shan, An Gong, Leyong Zeng, Wenzhi Ren, Lingchao Xiang, Ethan Gerhard, Jinshun Zhao, Jian Yang, Aiguo Wu
Targeted molecular imaging has attracted great attention in cancer diagnosis and treatment. However, most clinically used ultrasound contrast agents (UCAs) are non-targeted microbubbles seldom used for cancer imaging. Here, we fabricated fluorescent nanobubbles (NBs) by encapsulation of liquid tetradecafluorohexane (C6F14) within biodegradable photoluminescent polymers (BPLPs) through an emulsion-evaporation process and conjugation of PNBL-NPY ligand for specific targeting of Y1 receptors overexpressed in breast tumors...
February 2017: Biomaterials
https://www.readbyqxmd.com/read/27901181/evaluation-of-preoperative-ultrasonographic-and-biochemical-features-of-patients-with-aggressive-parathyroid-disease-is-there-a-reliable-predictive-marker
#10
Bekir Cakir, Sefika Burcak Polat, Mehmet Kilic, Didem Ozdemir, Cevdet Aydin, Nuran Süngü, Reyhan Ersoy
Objective: Parathyroid cancer (PC) represents < 1% of cases of PHPT. Tumors demonstrating atypical histopathologic features and don't fulfill criteria for carcinoma are classified as atypical adenomas (APA). The purpose of this study was to determine a biochemical or ultrasonographic feature that can predict aggressive disease requiring more extensive surgery and closer follow-up. Subjects and methods: Twenty eight patients operated for PHPT and diagnosed with atypical adenoma (23 patients) or carcinoma (5 patients) were enrolled in this study...
November 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27896329/myasthenia-gravis-with-acute-respiratory-failure-in-the-emergency-department
#11
Hasan Huseyin Kozak, Ali Ulvi Uca, Turgut Teke, Mustafa Altas, Emine Karatas
Acute respiratory failure (ARF) is defined as a sudden malfunction in the ability of respiratory system to maintain adequate gas exchange. Acute hypercapnic respiratory failure develops as a result of ventilation deficiency and it is defined as an increase of PaCO2 above 45 mmHg. Myasthenia Gravis (MG) is a sporadically developing auto-immune deficiency where the neuro-muscular transmission is affected and it is one of the important reasons for neurologically-induced respiratory distress. Here, we report a case of a 75-year-old male patient previously undiagnosed MG, who presented with ARF...
June 2016: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27892760/microbubble-mediated-ultrasound-drug-delivery-and-therapeutic-monitoring
#12
Charles A Sennoga, Emma Kanbar, Laurent Auboire, Paul-Armand Dujardin, Damien Fouan, Jean-Michel Escoffre, Ayache Bouakaz
Recent developments in ultrasound imaging and ultrasound contrast agents (UCAs) improved diagnostic confidence in echography and set into motion their combined use as a tool for drug delivery and therapeutic monitoring. Non-invasive, precise and targeted delivery of drug molecules to pathological tissues by employing different mechanisms of drug release is becoming feasible. Areas covered: We sought to describe: the nature and features of UCAs; outline current contrast-specific imaging modes; before describing a variety of strategies for using ultrasound and microbubbles as a drug delivery system...
December 11, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27860550/contrast-enhanced-us-guided-interventions-improving-success-rate-and-avoiding-complications-using-us-contrast-agents
#13
Dean Y Huang, Gibran T Yusuf, Mohammad Daneshi, Mohammad Ali Husainy, Raymond Ramnarine, Maria E K Sellars, Paul S Sidhu
Ultrasonography (US) is an established modality for intervention. The introduction of microbubble US contrast agents (UCAs) has the potential to further improve US imaging for intervention. According to licensing, UCAs are currently approved for clinical use in restricted situations, but many additional indications have become accepted as having clinical value. The use of UCAs has been shown to be safe, and there is no risk of renal toxic effects, unlike with iodinated or gadolinium contrast medium. Broadly speaking, UCAs can be injected into the bloodstream (intravascular use) or instilled into almost any accessible body cavity (endocavitary use), either in isolation or synchronously...
November 18, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27858294/sleep-quality-morningness-eveningness-preference-mood-profile-and-levels-of-serum-melatonin-in-migraine-patients-a-case-control-study
#14
Hasan Hüseyin Kozak, Murat Boysan, Ali Ulvi Uca, Adem Aydın, İbrahim Kılınç, Emine Genç, Mustafa Altaş, Dilara Cari Güngör, Keziban Turgut, Nejla Özer
The melatonin as the pineal gland's secretory product is implicated in the pathophysiology of migraine. Melatonin has critical functions in human physiology, and research underscores the importance of melatonin in circadian rhythm, sleep, and mood regulation. Clinical observations have indicated that migraine attacks have a seasonal, menstrual, and circadian timing, suggesting that chronobiological mechanisms and their alterations may causally involve in the etiology of the disease. However, the topic has received relatively little attention in the migraine literature...
November 17, 2016: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/27836683/fiddler-crabs-uca-spp-as-model-hosts-for-laboratory-infections-of-hematodinium-perezi
#15
Patricia A O'Leary, Jeffrey D Shields
The parasitic dinoflagellate, Hematodinium perezi, negatively impacts the commercially important blue crab, Callinectes sapidus. The parasite is a host generalist, but it has not been reported from littoral fiddler crabs living within a few meters of habitat known to harbor infected blue crabs. In the first study, populations of three species of fiddler crab were screened for natural infections. The infection status of field-collected and lab-inoculated crabs was determined by screening fresh hemolymph with a 0...
November 9, 2016: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/27835907/biodegradable-double-targeted-ptx-mpeg-plga-nanoparticles-for-ultrasound-contrast-enhanced-imaging-and-antitumor-therapy-in-vitro
#16
Jing Ma, Ming Shen, Chang Song Xu, Ying Sun, You Rong Duan, Lian Fang Du
A porous-structure nano-scale ultrasound contrast agent (UCA) was made of monomethoxypoly (ethylene glycol)-poly (lactic-co-glycolic acid) (mPEG-PLGA), and modified by double-targeted antibody: anti-carcinoembryonic antigen (CEA) and anti-carbohydrate antigen 19-9 (CA19-9), as a double-targeted nanoparticles (NPs). Anti-tumor drug paclitaxel (PTX) was encapsulated in the double-targeted nanoparticles (NPs). The morphor and release curve were characterized. We verified a certain anticancer effect of PTX-NPs through cytotoxicity experiments...
November 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27829697/experiments-with-claw-models-explain-the-function-of-the-waving-display-of-ilyoplax-pusilla-brachyura-dotillidae
#17
Daichi Izumi, Yoko Kawano, Yasuhisa Henmi
Males of the dotillid crab, Ilyoplax pusilla, perform waving displays during the reproductive season. Unlike many fiddler crabs (genus Uca), however, the function of the waving display is unclear for this species. Experiments using waving and static claw models over short (10 cm) and long (25 cm) distances were conducted to investigate responses by wandering females to artificial waving signals. In long-distance choice experiments, presuming undirected waving to unseen females as broadcast waving, females were equally likely to approach the waving and static claw sections during the non-reproductive season, but significantly more females (65 %) chose the waving claw section during the reproductive season...
2016: Journal of Ethology
https://www.readbyqxmd.com/read/27824024/ultrasound-contrast-agents
#18
REVIEW
Andre Ignee, Nathan S S Atkinson, Gudrun Schuessler, Christoph F Dietrich
Endoscopic ultrasound (EUS) plays an important role in imaging of the mediastinum and abdominal organs. Since the introduction of US contrast agents (UCA) for transabdominal US, attempts have been made to apply contrast-enhanced US techniques also to EUS. Since 2003, specific contrast-enhanced imaging was possible using EUS. Important studies have been published regarding contrast-enhanced EUS and the characterization of focal pancreatic lesions, lymph nodes, and subepithelial tumors. In this manuscript, we describe the relevant UCA, their application, and specific image acquisition as well as the principles of image tissue characterization using contrast-enhanced EUS...
November 2016: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/27816188/delirium-in-patients-with-acute-ischemic-stroke-admitted-to-the-non-intensive-stroke-unit-incidence-and-association-between-clinical-features-and-inflammatory-markers
#19
Hasan Hüseyin Kozak, Faruk Uğuz, İbrahim Kılınç, Ali Ulvi Uca, Osman Serhat Tokgöz, Zehra Akpınar, Nejla Özer
BACKGROUND: Stroke patients with development of delirium have unfavorable outcomes, higher mortality, longer hospitalizations, and a greater degree of dependence after discharge. Studies suggest that delirium is associated with abnormal immunological responses and a resultant increase in inflammatory markers. OBJECTIVE: Our aim was to determine whether there is an entity relationship between delirium, inflammation and acute ischemic stroke (AIS). METHODS: Sixty AIS patients admitted to the hospital were consecutively recruited...
October 24, 2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27807499/nanomaterials-incorporated-ultrasound-contrast-agents-for-cancer-theranostics
#20
Lei Fu, Heng-Te Ke
Nanotechnology provides various nanomaterials with tremendous functionalities for cancer diagnostics and therapeutics. Recently, theranostics has been developed as an alternative strategy for efficient cancer treatment through combination of imaging diagnosis and therapeutic interventions under the guidance of diagnostic results. Ultrasound (US) imaging shows unique advantages with excellent features of real-time imaging, low cost, high safety and portability, making US contrast agents (UCAs) an ideal platform for construction of cancer theranostic agents...
September 2016: Cancer Biology & Medicine
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