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https://www.readbyqxmd.com/read/28515326/semantic-closure-demonstrated-by-the-evolution-of-a-universal-constructor-architecture-in-an-artificial-chemistry
#1
Edward B Clark, Simon J Hickinbotham, Susan Stepney
We present a novel stringmol-based artificial chemistry system modelled on the universal constructor architecture (UCA) first explored by von Neumann. In a UCA, machines interact with an abstract description of themselves to replicate by copying the abstract description and constructing the machines that the abstract description encodes. DNA-based replication follows this architecture, with DNA being the abstract description, the polymerase being the copier, and the ribosome being the principal machine in expressing what is encoded on the DNA...
May 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28514880/the-uterocervical-angle-and-its-relationship-with-preterm-birth
#2
Alba Farràs Llobet, Laia Regincós Martí, Teresa Higueras, Inés Zulema Calero Fernández, Andrea Gascón Portalés, María M Goya Canino, Elena Carreras Moratonas
OBJECTIVES: To determine whether the uterocervical angle (UCA) correlates with the risk of spontaneous preterm birth (sPTB) <34 weeks and assess its interobserver variability. STUDY DESIGN: Case-control study of 275 women including 34 who started labor spontaneously and gave birth before 34 weeks of gestation (preterm group) and 241 who gave birth at term (control group). Images used to report cervical length were re-measured for UCA. RESULTS: Mean UCA in the second trimester was wider in the preterm group (105...
May 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28495870/early-life-experience-drives-short-term-acclimation-of-metabolic-and-osmoregulatory-traits-in-the-leaf-eared-mouse
#3
G Cavieres, M Nuñez-Villegas, F Bozinovic, P Sabat
We studied the putative effect of early experience on the physiological flexibility of metabolic and osmoregulatory traits in the leaf-eared mouse Phyllotis darwini, an altricial rodent inhabiting seasonal mediterranean environments. Adult individuals were collected in central Chile and maintained in breeding pairs. Pups were isolated after weaning and acclimated to different temperature (cold or warm) and water availability (unrestricted and restricted) until adulthood. Subsequently, individuals were re-acclimated to the opposite treatment...
May 11, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28492475/ambiguity-resolution-for-phase-based-3-d-source-localization-under-fixed-uniform-circular-array
#4
Xin Chen, Zhen Liu, Xizhang Wei
Under fixed uniform circular array (UCA), 3-D parameter estimation of a source whose half-wavelength is smaller than the array aperture would suffer from a serious phase ambiguity problem, which also appears in a recently proposed phase-based algorithm. In this paper, by using the centro-symmetry of UCA with an even number of sensors, the source's angles and range can be decoupled and a novel algorithm named subarray grouping and ambiguity searching (SGAS) is addressed to resolve angle ambiguity. In the SGAS algorithm, each subarray formed by two couples of centro-symmetry sensors can obtain a batch of results under different ambiguities, and by searching the nearest value among subarrays, which is always corresponding to correct ambiguity, rough angle estimation with no ambiguity is realized...
May 11, 2017: Sensors
https://www.readbyqxmd.com/read/28487935/folate-receptor-targeted-ultrasonic-pfob-nanoparticles-synthesis-characterization-and-application-in-tumor-targeted-imaging
#5
Keshi Li, Yahui Liu, Shengmin Zhang, Youfeng Xu, Jianshuai Jiang, Fengying Yin, Yue Hu, Baosan Han, Shuxiong Ge, Li Zhang, Yong Wang
In this study, we aimed to determine an effective strategy for the synthesis of folate receptor (FR) targeted-nanoparticles (FRNPs). The nanoparticles used as ultrasound contrast agents (UCAs) were composed of a liquid core of perfluorooctyl bromide (PFOB) liposome and a targeted shell chemically conjugated with folic acid (FA) and polyethylene glycol (PEG). This was done in order to avoid recognition and clearance by the mononuclear phagocyte system [also known as the reticuloendothelial system (RES)] and enhance the targeting capability of the nanoparticles to tumors overexpressing folate receptor (FR)...
June 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28480544/resolving-nmr-signals-of-short-chain-fatty-acid-mixtures-using-unsupervised-component-analysis
#6
Jorge Costa Pereira, Ivana Jarak, Rui Albuquerque Carvalho
Nuclear Magnetic Resonance (NMR) is a very powerful instrumental technique suited to identify and characterize organic compounds. NMR has been successfully used in the analysis of complex biological and environmental samples, however these applications are still rather limited. In this work we describe Unsupervised Component Analysis (UCA) as a multivariate unsupervised method suited to identify the number of relevant NMR signal contributions and to deconvolve mixed signals into signal individual sources and respective contributions...
May 8, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/28465560/increased-cis-to-trans-urocanic-acid-ratio-in-the-skin-of-chronic-spontaneous-urticaria-patients
#7
Duy Le Pham, Kyung-Min Lim, Kyung-Mi Joo, Hae-Sim Park, Donald Y M Leung, Young-Min Ye
Increased filaggrin expression was found to be correlated with severity scores in chronic spontaneous urticaria (CSU); however, the role of filaggrin breakdown products (FBPs) in CSU has not been studied. We collected stratum corneum (SC) specimens from the volar forearms of 10 CSU patients, 10 AD patients, and 10 healthy normal controls (NCs) and measured contents of FBPs (pyrrolidone carboxylic acid [PCA] and urocanic acid [UCA]) using UPLC-MS/MS, transepidermal water loss (TEWL) and epidermal pH. Compared to NCs, cis-UCA level was increased in CSU lesions (P < 0...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28465130/urothelial-carcinoma-involving-the-ureteral-orifice-a-clinicopathologic-analysis-of-93-cases
#8
Anand C Annan, Keith A Stevens, Adeboye O Osunkoya
Although tumors involving the bladder and ureter have been well described, there are only few studies in the pathology literature specifically analyzing tumors involving the ureteral orifice (UO). A search was performed for biopsy and resection specimens (transurethral resection, radical cystectomy/cystoprostatectomy, nephroureterectomy and bladder cuff resection) of urothelial carcinoma (UCa) involving the UO. Ninety three cases were identified. Sixty two (67%) patients were male. Mean patient age was 71years (range: 43-91years)...
April 29, 2017: Human Pathology
https://www.readbyqxmd.com/read/28461155/akaryotes-and-eukaryotes-are-independent-descendants-of-a-universal-common-ancestor
#9
Ajith Harish, Charles G Kurland
We reconstructed a global tree of life (ToL) with non-reversible and non-stationary models of genome evolution that root trees intrinsically. We implemented Bayesian model selection tests and compared the statistical support for four conflicting ToL hypotheses. We show that reconstructions obtained with a Bayesian implementation (Klopfstein et al., 2015) is consistent with reconstructions obtained with an empirical Sankoff parsimony (ESP) implementation (Harish et al. 2013). Both are based on the genome contents of coding sequences for protein domains (superfamilies) from hundreds of genomes...
April 28, 2017: Biochimie
https://www.readbyqxmd.com/read/28445533/influence-of-temperature-on-daily-locomotor-activity-in-the-crab-uca-pugilator
#10
Audrey M Mat, Gideon P Dunster, Valerio Sbragaglia, Jacopo Aguzzi, Horacio O de la Iglesia
Animals living in the intertidal zone are exposed to prominent temperature changes. To cope with the energetic demands of environmental thermal challenges, ectotherms rely mainly on behavioral responses, which may change depending on the time of the day and seasonally. Here, we analyze how temperature shapes crabs' behavior at 2 different times of the year and show that a transition from constant cold (13.5°C) to constant warm (17.5°C) water temperature leads to increased locomotor activity levels throughout the day in fiddler crabs (Uca pugilator) collected during the summer...
2017: PloS One
https://www.readbyqxmd.com/read/28438436/effects-of-dextran-sulfate-sodium-induced-experimental-colitis-on-cytochrome-p450-activities-in-rat-liver-kidney-and-intestine
#11
Nan Hu, Yanjuan Huang, Xuejiao Gao, Sai Li, Zhixiang Yan, Bin Wei, Ru Yan
Dextran sulfate sodium (DSS) induced experimental colitis presents a histologic resemblance to human ulcerative colitis (UC). Altered cytochrome P450s (CYPs) have been reported in this model and patients with UC. In this study, six CYPs activities were quantitatively determined in microsomes of liver (RLMs), kidney (RRMs) and intestine (RIMs) from rats with colitis at acute (5% DSS for 7 days, UCA) and remission (7-day DSS treatment followed by 7-day cessation, UCR) phases and compared with normal rats. Generally, CYPs activities varied with isoform, organ, and disease status...
April 21, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28436861/uncorrelated-component-analysis-based-hashing
#12
Sungryull Sohn, Hyunwoo Kim, Junmo Kim
The approximate nearest neighbor (ANN) search problem is important in applications such as information retrieval. Several hashing-based search methods that provide effective solutions to the ANN search problem have been proposed. However, most of these focus on similarity preservation and coding error minimization, and pay little attention to optimizing the precision-recall curve or receiver operating characteristic curve. In this paper, we propose a novel projection-based hashing method that attempts to maximize precision and recall...
April 18, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28428448/unruptured-cerebral-aneurysms-in-elderly-patients
#13
Tomohito Hishikawa, Isao Date
The prevalence of unruptured cerebral aneurysms (UCAs) in elderly patients is increasing in our aging population. UCA management in elderly patients has some difficulties, such as reduced life expectancy, increased comorbidities and treatment risks, and poor prognosis in case of rupture. In this review article, we summarize the most recent findings on the natural history, therapeutic options and treatment results for UCAs exclusively in elderly patients, and describe possible medical treatments for patients with UCAs...
April 19, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28405396/multimodal-communication-in-courting-fiddler-crabs-reveals-male-performance-capacities
#14
Sophie L Mowles, Michael Jennions, Patricia R Y Backwell
Courting males often perform different behavioural displays that demonstrate aspects of their quality. Male fiddler crabs, Uca sp., are well known for their repetitive claw-waving display during courtship. However, in some species, males produce an additional signal by rapidly stridulating their claw, creating a 'drumming' vibrational signal through the substrate as a female approaches, and even continue to drum once inside their burrow. Here, we show that the switch from waving to drumming might provide additional information to the female about the quality of a male, and the properties of his burrow (multiple message hypothesis)...
March 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28376483/long-non-coding-rnas-in-cardiac-remodeling
#15
Shutong Shen, Huimin Jiang, Yihua Bei, Junjie Xiao, Xinli Li
Cardiac remodeling occurs after stress to the heart, manifested as pathological processes, including hypertrophy and apoptosis of cardiomyocytes, dysfunction of vascular endothelial cells and vascular smooth muscle cells as well as differentiation and proliferation of fibroblasts, ultimately resulting in progression of cardiovascular diseases. Emerging evidence has revealed that long non-coding RNAs (lncRNAs) acted as powerful and dynamic modifiers of cardiac remodeling. LncRNAs including Chaer, Chast, Mhrt, CHRF, ROR, H19, and MIAT have been implicated in cardiac hypertrophy while NRF, H19, APF, CARL, UCA, Mhrt and several other lncRNAs (n379599, n379519, n384640, n380433 and n410105) in cardiomyocyte loss and extracellular matrix remodeling...
April 3, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28365722/ocappi-db-an-oligonucleotide-probe-database-for-pathogen-identification-through-hybridization-capture
#16
Cyrielle Gasc, Antony Constantin, Faouzi Jaziri, Pierre Peyret
The detection and identification of bacterial pathogens involved in acts of bio- and agroterrorism are essential to avoid pathogen dispersal in the environment and propagation within the population. Conventional molecular methods, such as PCR amplification, DNA microarrays or shotgun sequencing, are subject to various limitations when assessing environmental samples, which can lead to inaccurate findings. We developed a hybridization capture strategy that uses a set of oligonucleotide probes to target and enrich biomarkers of interest in environmental samples...
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/28346377/impact-of-beamforming-on-the-path-connectivity-in-cognitive-radio-ad-hoc-networks
#17
Le The Dung, Tran Dinh Hieu, Seong-Gon Choi, Byung-Seo Kim, Beongku An
This paper investigates the impact of using directional antennas and beamforming schemes on the connectivity of cognitive radio ad hoc networks (CRAHNs). Specifically, considering that secondary users use two kinds of directional antennas, i.e., uniform linear array (ULA) and uniform circular array (UCA) antennas, and two different beamforming schemes, i.e., randomized beamforming and center-directed to communicate with each other, we study the connectivity of all combination pairs of directional antennas and beamforming schemes and compare their performances to those of omnidirectional antennas...
March 27, 2017: Sensors
https://www.readbyqxmd.com/read/28290353/image-interpretation-performance-a-longitudinal-study-from-novice-to-professional
#18
C Wright, P Reeves
PURPOSE: Universities need to deliver educational programmes that create radiography graduates who are ready and able to participate in abnormality detection schemes, ultimately delivering safe and reliable performance because junior doctors are exposed to the risk of misdiagnosis if unsupported by other healthcare professionals. Radiographers are ideally suited to this role having the responsibility for conducting the actual X-ray examination. METHOD: The image interpretation performance of one cohort of student radiographers was measured upon enrolment from UCAS in the first week of university education and then again prior to graduation using RadBench (n = 23)...
February 2017: Radiography
https://www.readbyqxmd.com/read/28282792/effects-of-kinesio-taping-and-exercise-on-forward-head-posture
#19
Hsu-Sheng Shih, Shu-Shi Chen, Su-Chun Cheng, Hsun-Wen Chang, Pei-Rong Wu, Jin-Shiou Yang, Yi-Shuang Lee, Jui-Yi Tsou
BACKGROUND: Little is known about the effects of Kinesio taping and therapeutic exercise on correcting forward head posture. OBJECTIVE: To compare Kinesio taping versus therapeutic exercise for forward head posture on static posture, dynamic mobility and functional outcomes. METHODS: Sixty subjects (31 women, 29 men) with forward head postures participated in this study. They were randomly assigned to either one of the three groups: (1) exercise group (n = 20), (2) taping group (n = 20), and (3) control groups (n = 20)...
March 3, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28280560/territorial-battles-between-fiddler-crab-species
#20
H L Clark, P R Y Backwell
Many species worldwide are impacted by habitat loss. This may result in increased competition both within species and between species. Many studies have demonstrated that when two previously non-overlapping species are forced to compete over a resource, one species is likely to become dominant over the other. This study explores the impact a larger species of fiddler crab (Tabuca elegans-previously known as Uca elegans) has when invading an area previously used solely by a smaller species (Austruca mjoebergi-previously known as Uca mjoebergi)...
January 2017: Royal Society Open Science
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