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Jacob M Taylor, Lyanne M Kieneker, Martin H de Borst, Sipke T Visser, Ido P Kema, Stephan J L Bakker, Ron T Gansevoort
Introduction: High urinary calcium excretion (UCaE) has been shown to lead to accelerated renal function decline in individuals with renal tubular diseases. It is not known whether this association also exists in the general population. Therefore, we investigated whether high UCaE is associated with risk of developing chronic kidney disease (CKD) in community-dwelling subjects. Methods: Urine samples of 5491 subjects who were free of CKD at baseline and participated in the Prevention of Renal and Vascular End-Stage Disease study (a prospective, observational, general population-based cohort of Dutch men and women aged 28-75 years) were examined for UCaE...
May 2017: KI Reports
Jesús Sánchez-Márquez, David Zorrilla, Víctor García, Manuel Fernández
In the present work, a new methodology defined for obtaining reactivity indices (philicities) is proposed. This is based on reactivity functions such as the Fukui function or the dual descriptor, and makes it possible to project the information from reactivity functions onto molecular orbitals, instead of onto the atoms of the molecule (atomic reactivity indices). The methodology focuses on the molecules' natural bond orbitals (bond reactivity indices) because these orbitals have the advantage of being localized, allowing the reaction site of an electrophile or nucleophile to be determined within a very precise molecular region...
December 22, 2017: Journal of Molecular Modeling
Guang-Qian Xiao, Mary M Barrett, Qi Yang, Pamela D Unger
Muscle invasive bladder cancer, an aggressive disease with heterogeneous molecular profiles, has recently been subclassified into three major molecular subtypes -basal, luminal and "p53-like" urothelial carcinomas (UCas), which bear prognostic and therapeutic implication. Similar to breast cancer, basal and luminal subtype UCas are designated by basal (CK5/14) and luminal (CK20) markers. The "p53-like" subtype presents with wild-type p53 gene with upregulated p53 pathways and is implicated in chemoresistance...
December 16, 2017: Pathology Oncology Research: POR
Bastian Joffroy, Yavuz O Uca, Domen Prešern, Jonathan P K Doye, Thorsten L Schmidt
Biophysical properties of DNA such as its longitudinal and torsional persistence length govern many processes and phenomena in biology, DNA nanotechnology and biotechnology. It has, for example, long been known that the circularization efficiency of short DNA fragments shows a periodic pattern where fragments with integer helical turns circularize much more efficiently than those with odd helical half turns due to stronger stacking of duplex ends. Small DNA circles can serve as templates for rolling circle amplification (RCA), which is a common and extremely robust amplification mechanism for nucleic acids...
December 9, 2017: Nucleic Acids Research
Er-Jiao Xu, Man Zhang, Kai Li, Zhong-Zhen Su, Ying-Lin Long, Qing-Jin Zeng, Huan-Yi Guo, Rong-Qin Zheng
The goal of this study was to investigate intracavitary contrast-enhanced ultrasound (IC-CEUS) measures in the management of post-surgical gastrointestinal (GI) fistula throughout detection, treatment and follow-up. From June 2010 to August 2016, patients who were administered ultrasound contrast agent (UCA) via a drainage tube for IC-CEUS were enrolled and retrospectively analyzed. They were suspected of having GI anastomotic fistulas or had been found to have fluid collections with ultrasound that were accompanied by abdominal pain or fever after surgical procedures...
December 8, 2017: Ultrasound in Medicine & Biology
Mustafa Zafer Temiz, Emrah Yuruk, Kasim Ertas, Oguzhan Zengi, Atilla Semercioz
PURPOSE: To investigate whether atorvastatin has favorable effects on urinary metabolic risk factors associated with urolithiasis. METHODS: Sixteen male Sprague-Dawley rats were randomly divided into two groups, and baseline spot and 24-h urine samples were collected. Distilled water and atorvastatin were administered to rats during 4 weeks in the control and atorvastatin groups, respectively. At the end of the experimental procedure, spot and 24-h urine samples were collected again...
December 2, 2017: International Urology and Nephrology
Himanshu Shekhar, Nathaniel J Smith, Jason L Raymond, Christy K Holland
Physical characterization of an ultrasound contrast agent (UCA) aids in its safe and effective use in diagnostic and therapeutic applications. The goal of this study was to investigate the impact of temperature on the size distribution, shell properties, and stability of Definity®, a U.S. Food and Drug Administration-approved UCA used for left ventricular opacification. A Coulter counter was modified to enable particle size measurements at physiologic temperatures. The broadband acoustic attenuation spectrum and size distribution of Definity® were measured at room temperature (25 °C) and physiologic temperature (37 °C) and were used to estimate the viscoelastic shell properties of the agent at both temperatures...
November 22, 2017: Ultrasound in Medicine & Biology
Tiffany F Mao, Ata Bajwa, Preetham Muskula, Tina R Coggins, Kevin Kennedy, Anthony Magalski, David G Skolnick, Michael L Main
Previous studies using 2-dimensional non-contrast echocardiography have reported a post-ST segment elevation myocardial infarction (STEMI) left ventricular (LV) thrombus incidence of 3% to 24%. However, these studies were not performed with ultrasound contrast agents (UCAs), which improve accuracy in the diagnosis of LV thrombus. We aimed to determine the early incidence and clinical correlates of LV thrombus in a large consecutive cohort of patients with STEMI. This study included consecutive patients admitted to Saint Luke's Mid America Heart Institute with STEMI who also underwent early percutaneous coronary intervention (PCI) and an echocardiogram...
October 10, 2017: American Journal of Cardiology
Marie-Elisa Pinson, Romain Pogorelcnik, Franck Court, Philippe Arnaud, Catherine Vaurs-Barriere
Abstract: L1 Chimeric Transcripts (LCTs) are initiated by repeated LINE-1 element antisense promoters and include the L1 5'UTR sequence in antisense orientation followed by the adjacent genomic region. LCTs have been characterized mainly using bioinformatics approaches to query dbEST. To take advantage of NGS data to unravel the transcriptome composition, we developed Chimeric LIne Finder (CLIFinder), a new bioinformatics tool. Using oriented paired-end RNA-seq data, we demonstrated that CLIFinder can identify genome-wide transcribed chimera sequences corresponding to potential LCTs...
October 23, 2017: Bioinformatics
Chad W Washington, L Ian Taylor, Robert J Dambrino, Paul R Clark, Gregory J Zipfel
OBJECTIVE The Agency of Healthcare Research and Quality (AHRQ) has defined Patient Safety Indicators (PSIs) for assessments in quality of inpatient care. The hypothesis of this study is that, in the treatment of unruptured cerebral aneurysms (UCAs), PSI events are less likely to occur in hospitals meeting the volume thresholds defined by The Joint Commission for Comprehensive Stroke Center (CSC) certification. METHODS Using the 2002-2011 National (Nationwide) Inpatient Sample, patients treated electively for a nonruptured cerebral aneurysm were selected...
October 20, 2017: Journal of Neurosurgery
Thomas E Moody, Curtis L Spraitzar, Elizabeth Eisenhart, Scott Tully
To determine the impact of the American Urological Association's (AUA) guideline for early detection of prostate cancer that recommends against routine screening in men aged 40 to 54 years at average risk (eg, white men without a family history of prostate cancer), we undertook a study of 973 men who previously underwent a prostate biopsy at Urology Centers of Alabama (UCA) over the 5-year period from 2010 to 2014. We retrospectively reviewed the results of the prostate biopsies performed by urologists at UCA-and, where applicable, the final surgical pathology results and compared the results by race and family history...
2017: Reviews in Urology
Zhiyan Li, Renzhi Hu, Pinhua Xie, Haichao Wang, Keding Lu, Dan Wang
Dinitrogen pentoxide (N2O5) is one of the basic trace gases which plays a key role in nighttime atmosphere. An intercomparison and validation of different N2O5 measurement methods is important for determining the true accuracy of these methods. Cavity ring down spectroscopy (CRDS) and cavity enhanced absorption spectrometer (CEAS) were used to measure N2O5 at the campus of the University of Chinese Academy of Sciences (UCAS) from February 21, 2016 to March 4, 2016. The detection limits were 1.6ppt (1σ) at 30s intervals for the CEAS instrument and 3...
February 1, 2018: Science of the Total Environment
Marco E Franco, Bruce E Felgenhauer, Paul L Klerks
The intensive drilling and extraction of fossil fuels in the Gulf of Mexico result in a considerable risk for oil spills impacting its coastal ecosystems. Impacts are more likely to be far-reaching if the oil affects ecosystem engineers like fiddler crabs, whose activities modify biogeochemical processes in the sediment. The present study investigated effects of oil on the fiddler crabs Uca longisignalis and Uca panacea; important as ecosystem engineers and as prey for a wide variety of species. The present study used mesocosms and microcosms to investigate effects of crude oil on fiddler crab burrowing and to assess cellular and tissue damage by the oil...
September 11, 2017: Environmental Toxicology and Chemistry
Lu Xu, Jianjun Zhou, Jingyu Liu, Yong Liu, Lei Wang, Ruiwei Jiang, Zhenyu Diao, Guijun Yan, Bruno Pèault, Haixiang Sun, Lijun Ding
Human mesenchymal stem cells derived from the umbilical cord (UC) are a favorable source for allogeneic cell therapy. Here, we successfully isolated the stem cells derived from three different compartments of the human UC, including perivascular stem cells derived from umbilical arteries (UCA-PSCs), perivascular stem cells derived from umbilical vein (UCV-PSCs), and mesenchymal stem cells derived from Wharton's jelly (WJ-MSCs). These cells had the similar phenotype and differentiation potential toward adipocytes, osteoblasts, and neuron-like cells...
2017: Stem Cells International
Hanna-Mari Jauhonen, Jarmo Laihia, Olli Oksala, Johanna Viiri, Reijo Sironen, Päivi Alajuuma, Kai Kaarniranta, Lasse Leino
PURPOSE: Our purpose was to investigate the effect of locally administered cis-urocanic (cis-UCA) in two experimental models of allergic conjunctivitis. METHODS: The compound 48/80 (C48/80)-induced ocular irritation model (IgE-independent) and the ovalbumin (OA)-induced ocular allergy model (IgE-mediated) were used to test and compare the effect of cis-UCA on dexamethasone, ketotifen and olopatadine. In the C48/80 model, clinical severity scoring from photographs, immunohistochemical analysis of nuclear Ki-67 antigen to quantify actively proliferating epithelial cells and of caspase-3 enzyme to identify apoptotic activity in the conjunctival tissue were used...
August 24, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
Keith J Petrie, Kate MacKrill, Christina Derksen, Nicola Dalbeth
OBJECTIVE: Inaccurate lay views of an illness can lead to the adoption of unhelpful coping strategies and treatments. Gout is an example of an illness where the popular view of the condition conflicts with a modern understanding of the illness by overemphasizing the role of diet and alcohol in the development and management of the disease. In this study we investigated the effect of renaming gout as urate crystal arthritis on the perceptions of the illness. METHOD: One-hundred and 89 supermarket shoppers participated in a study examining the perceptions of different types of arthritis...
August 24, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Laurent Pierot, Matthias Gawlitza, Sébastien Soize
Unruptured intracranial aneurysms (UIA) have a high prevalence (3.2%) and are increasingly diagnosed with modern imaging tools. The main risk of UIA is their rupture associated with intracranial bleeding with often severe clinical consequences. Areas covered: This review discusses the management strategy of UIAs, based on the large series of the literature (ISUIA, ATENA, UCAS, …), knowing that no randomized controlled trial is available to compare different strategies. The different endovascular treatments are described...
October 2017: Expert Review of Neurotherapeutics
Donald R Deis, John W Fleeger, Stefan M Bourgoin, Irving A Mendelssohn, Qianxin Lin, Aixin Hou
Salt marshes in northern Barataria Bay, Louisiana, USA were oiled, sometimes heavily, in the aftermath of the Deepwater Horizon oil spill. Previous studies indicate that fiddler crabs (in the genus Uca) and the salt marsh periwinkle (Littoraria irrorata) were negatively impacted in the short term by the spill. Here, we detail longer-term effects and recovery from moderate and heavy oiling over a 3-year span, beginning 30 months after the spill. Although neither fiddler crab burrow density nor diameter differed between oiled and reference sites when combined across all sampling events, these traits differed among some individual sampling periods consistent with a pattern of lingering oiling impacts...
2017: PeerJ
Ke-Han Yao, Jehn-Ruey Jiang, Chung-Hsien Tsai, Zong-Syun Wu
This paper investigates how to efficiently charge sensor nodes in a wireless rechargeable sensor network (WRSN) with radio frequency (RF) chargers to make the network sustainable. An RF charger is assumed to be equipped with a uniform circular array (UCA) of 12 antennas with the radius λ, where λ is the RF wavelength. The UCA can steer most RF energy in a target direction to charge a specific WRSN node by the beamforming technology. Two evolutionary algorithms (EAs) using the evolution strategy (ES), namely the Evolutionary Beamforming Optimization (EBO) algorithm and the Evolutionary Beamforming Optimization Reseeding (EBO-R) algorithm, are proposed to nearly optimize the power ratio of the UCA beamforming peak side lobe (PSL) and the main lobe (ML) aimed at the given target direction...
August 20, 2017: Sensors
Alexa Tullis, Corinne H T Straube
Models proposed to explain sexually selected structures assume that these traits are costly. However, studies investigating the impact of such structures on locomotory costs have produced inconsistent results. Male fiddler crabs possess a large sexually selected claw and are ideal for assessing the impact of a sexually selected trait on the cost of locomotion. Here, we measured the energy expenditure of clawed, declawed and artificially loaded crabs during sustained exercise by measuring oxygen consumption and blood lactate levels...
October 15, 2017: Journal of Experimental Biology
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