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https://www.readbyqxmd.com/read/28699518/nano-sized-ultrasound-contrast-agents-for-cancer-therapy-and-theranostics
#1
Hao Li, Shenglong Gan, Shi-Ting Feng, Guofu Zhou, Zhi Dong, Rongqin Zheng, Zi-Ping Li
Ultrasound contrast agents (UCA) represented by gas-filled microbubble, can provide simultaneous and co-localized enhancement on image contrast to help disease diagnosis by highlighting tissue borders. Nowadays, Some UCAs (e.g. Levovist®, Optison®, Definity®, and Sonovue®) are commercially available, and have been clinically utilized for enhanced ultrasonography in the US, Canada, Europe, Asia and so on. However, their large diameters (1~10 μm) mainly hinder more precise and deeper applications in the imaging of capillary-abundant organs or tissues (e...
July 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28643665/sonographic-landmarks-to-differentiate-false-labor-and-early-true-labor-as-a-possible-new-application-of-ultrasound-in-labor-ward
#2
A Bouzid, M Kehila, H Trabelsi, H S Abouda, R Ben Hmid, M B Chanoufi
OBJECTIVE: To evaluate discrimination of clinical parameters and ultrasound examination to differentiate "false labor" and "true labor". METHODS: In a prospective study during a period of 6 months, a total of 178 patients in term (37-41 weeks) consulting our obstetric unit for uterine contraction, were enrolled. Patients were examined separately by a midwife and a resident and separated into "true labor group" and "false labor group". The clinical characteristics of true versus false labor patients were compared...
April 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28598386/a-noise-removal-method-for-uniform-circular-arrays-in-complex-underwater-noise-environments-with-low-snr
#3
Huijun Xia, Kunde Yang, Yuanliang Ma, Yong Wang, Yaxiong Liu
Generally, many beamforming methods are derived under the assumption of white noise. In practice, the actual underwater ambient noise is complex. As a result, the noise removal capacity of the beamforming method may be deteriorated considerably. Furthermore, in underwater environment with extremely low signal-to-noise ratio (SNR), the performances of the beamforming method may be deteriorated. To tackle these problems, a noise removal method for uniform circular array (UCA) is proposed to remove the received noise and improve the SNR in complex noise environments with low SNR...
June 9, 2017: Sensors
https://www.readbyqxmd.com/read/28589835/fears-double-dose-of-debt-is-deterring-mature-students
#4
Erin Dean
With the end of bursaries for nursing students in England a matter of weeks away, academics have told Nursing Standard of the need to ensure mature students are not put off by funding changes. About 6,000 fewer mature students have applied to start nursing courses this coming autumn compared with last year. Figures from the university admissions service UCAS show a 28% drop in the number of over-25s applying in England.
June 7, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28574467/research-and-analysis-on-the-localization-of-a-3-d-single-source-in-lossy-medium-using-uniform-circular-array
#5
Bing Xue, Xiaodong Qu, Guangyou Fang, Yicai Ji
In this paper, the methods and analysis for estimating the location of a three-dimensional (3-D) single source buried in lossy medium are presented with uniform circular array (UCA). The mathematical model of the signal in the lossy medium is proposed. Using information in the covariance matrix obtained by the sensors' outputs, equations of the source location (azimuth angle, elevation angle, and range) are obtained. Then, the phase and amplitude of the covariance matrix function are used to process the source localization in the lossy medium...
June 2, 2017: Sensors
https://www.readbyqxmd.com/read/28552267/recent-advances-in-ultrasound-based-diagnosis-and-therapy-with-micro-and-nanometer-sized-formulations
#6
REVIEW
Nihan Güvener, Lia Appold, Federica de Lorenzi, Susanne K Golombek, Larissa Y Rizzo, Twan Lammers, Fabian Kiessling
Ultrasound (US) is one of the most frequently used imaging methods in the clinic. The broad spectrum of its applications can be increased by the use of gas-filled microbubbles (MB) as ultrasound contrast agents (UCA). In recent years, also nanoscale UCA like nanobubbles (NB), echogenic liposomes (ELIP) and nanodroplets have been developed, which in contrast to MB, are able to extravasate from the vessels into the tissue. New disease-specific UCA have been designed for the assessment of tissue biomarkers and advanced US to a molecular imaging modality...
May 24, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28515326/semantic-closure-demonstrated-by-the-evolution-of-a-universal-constructor-architecture-in-an-artificial-chemistry
#7
Edward B Clark, Simon J Hickinbotham, Susan Stepney
We present a novel stringmol-based artificial chemistry system modelled on the universal constructor architecture (UCA) first explored by von Neumann. In a UCA, machines interact with an abstract description of themselves to replicate by copying the abstract description and constructing the machines that the abstract description encodes. DNA-based replication follows this architecture, with DNA being the abstract description, the polymerase being the copier, and the ribosome being the principal machine in expressing what is encoded on the DNA...
May 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28514880/the-uterocervical-angle-and-its-relationship-with-preterm-birth
#8
Alba Farràs Llobet, Laia Regincós Martí, Teresa Higueras, Inés Zulema Calero Fernández, Andrea Gascón Portalés, María M Goya Canino, Elena Carreras Moratonas
OBJECTIVES: The objective of this study is to determine whether the uterocervical angle (UCA) correlates with the risk of spontaneous preterm birth (sPTB) < 34 weeks and assess its interobserver variability. STUDY DESIGN: Case-control study of 275 women including 34 who started labor spontaneously and gave birth before 34 weeks of gestation (preterm group) and 241 who gave birth at term (control group). Images used to report cervical length were re-measured for UCA...
June 6, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28495870/early-life-experience-drives-short-term-acclimation-of-metabolic-and-osmoregulatory-traits-in-the-leaf-eared-mouse
#9
G Cavieres, M Nuñez-Villegas, F Bozinovic, P Sabat
We studied the putative effect of early experience on the physiological flexibility of metabolic and osmoregulatory traits in the leaf-eared mouse Phyllotis darwini, an altricial rodent inhabiting seasonal mediterranean environments. Adult individuals were collected in central Chile and maintained in breeding pairs. Pups were isolated after weaning and acclimated to different temperature (cold or warm) and water availability (unrestricted and restricted) until adulthood. Subsequently, individuals were re-acclimated to the opposite treatment...
May 11, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28492475/ambiguity-resolution-for-phase-based-3-d-source-localization-under-fixed-uniform-circular-array
#10
Xin Chen, Zhen Liu, Xizhang Wei
Under fixed uniform circular array (UCA), 3-D parameter estimation of a source whose half-wavelength is smaller than the array aperture would suffer from a serious phase ambiguity problem, which also appears in a recently proposed phase-based algorithm. In this paper, by using the centro-symmetry of UCA with an even number of sensors, the source's angles and range can be decoupled and a novel algorithm named subarray grouping and ambiguity searching (SGAS) is addressed to resolve angle ambiguity. In the SGAS algorithm, each subarray formed by two couples of centro-symmetry sensors can obtain a batch of results under different ambiguities, and by searching the nearest value among subarrays, which is always corresponding to correct ambiguity, rough angle estimation with no ambiguity is realized...
May 11, 2017: Sensors
https://www.readbyqxmd.com/read/28487935/folate-receptor-targeted-ultrasonic-pfob-nanoparticles-synthesis-characterization-and-application-in-tumor-targeted-imaging
#11
Keshi Li, Yahui Liu, Shengmin Zhang, Youfeng Xu, Jianshuai Jiang, Fengying Yin, Yue Hu, Baosan Han, Shuxiong Ge, Li Zhang, Yong Wang
In this study, we aimed to determine an effective strategy for the synthesis of folate receptor (FR) targeted-nanoparticles (FRNPs). The nanoparticles used as ultrasound contrast agents (UCAs) were composed of a liquid core of perfluorooctyl bromide (PFOB) liposome and a targeted shell chemically conjugated with folic acid (FA) and polyethylene glycol (PEG). This was done in order to avoid recognition and clearance by the mononuclear phagocyte system [also known as the reticuloendothelial system (RES)] and enhance the targeting capability of the nanoparticles to tumors overexpressing folate receptor (FR)...
June 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28480544/resolving-nmr-signals-of-short-chain-fatty-acid-mixtures-using-unsupervised-component-analysis
#12
Jorge Costa Pereira, Ivana Jarak, Rui Albuquerque Carvalho
Nuclear magnetic resonance (NMR) is a very powerful instrumental technique suited to identify and characterize organic compounds. NMR has been successfully used in the analysis of complex biological and environmental samples; however, these applications are still rather limited. In this work, we describe unsupervised component analysis as a multivariate unsupervised method suited to identify the number of relevant NMR signal contributions and to deconvolve mixed signals into signal individual sources and respective contributions...
May 8, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/28465560/increased-cis-to-trans-urocanic-acid-ratio-in-the-skin-of-chronic-spontaneous-urticaria-patients
#13
Duy Le Pham, Kyung-Min Lim, Kyung-Mi Joo, Hae-Sim Park, Donald Y M Leung, Young-Min Ye
Increased filaggrin expression was found to be correlated with severity scores in chronic spontaneous urticaria (CSU); however, the role of filaggrin breakdown products (FBPs) in CSU has not been studied. We collected stratum corneum (SC) specimens from the volar forearms of 10 CSU patients, 10 AD patients, and 10 healthy normal controls (NCs) and measured contents of FBPs (pyrrolidone carboxylic acid [PCA] and urocanic acid [UCA]) using UPLC-MS/MS, transepidermal water loss (TEWL) and epidermal pH. Compared to NCs, cis-UCA level was increased in CSU lesions (P < 0...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28465130/urothelial-carcinoma-involving-the-ureteral-orifice-a-clinicopathologic-analysis-of-93-cases
#14
Anand C Annan, Keith A Stevens, Adeboye O Osunkoya
Although tumors involving the bladder and ureter have been well described, there are only few studies in the pathology literature specifically analyzing tumors involving the ureteral orifice (UO). A search was performed for biopsy and resection specimens (transurethral resection, radical cystectomy/cystoprostatectomy, nephroureterectomy and bladder cuff resection) of urothelial carcinoma (UCa) involving the UO. Ninety three cases were identified. Sixty two (67%) patients were male. Mean patient age was 71years (range: 43-91years)...
April 29, 2017: Human Pathology
https://www.readbyqxmd.com/read/28461155/akaryotes-and-eukaryotes-are-independent-descendants-of-a-universal-common-ancestor
#15
Ajith Harish, Charles G Kurland
We reconstructed a global tree of life (ToL) with non-reversible and non-stationary models of genome evolution that root trees intrinsically. We implemented Bayesian model selection tests and compared the statistical support for four conflicting ToL hypotheses. We show that reconstructions obtained with a Bayesian implementation (Klopfstein et al., 2015) is consistent with reconstructions obtained with an empirical Sankoff parsimony (ESP) implementation (Harish et al. 2013). Both are based on the genome contents of coding sequences for protein domains (superfamilies) from hundreds of genomes...
April 28, 2017: Biochimie
https://www.readbyqxmd.com/read/28445533/influence-of-temperature-on-daily-locomotor-activity-in-the-crab-uca-pugilator
#16
Audrey M Mat, Gideon P Dunster, Valerio Sbragaglia, Jacopo Aguzzi, Horacio O de la Iglesia
Animals living in the intertidal zone are exposed to prominent temperature changes. To cope with the energetic demands of environmental thermal challenges, ectotherms rely mainly on behavioral responses, which may change depending on the time of the day and seasonally. Here, we analyze how temperature shapes crabs' behavior at 2 different times of the year and show that a transition from constant cold (13.5°C) to constant warm (17.5°C) water temperature leads to increased locomotor activity levels throughout the day in fiddler crabs (Uca pugilator) collected during the summer...
2017: PloS One
https://www.readbyqxmd.com/read/28438436/effects-of-dextran-sulfate-sodium-induced-experimental-colitis-on-cytochrome-p450-activities-in-rat-liver-kidney-and-intestine
#17
Nan Hu, Yanjuan Huang, Xuejiao Gao, Sai Li, Zhixiang Yan, Bin Wei, Ru Yan
Dextran sulfate sodium (DSS) induced experimental colitis presents a histologic resemblance to human ulcerative colitis (UC). Altered cytochrome P450s (CYPs) have been reported in this model and patients with UC. In this study, six CYPs activities were quantitatively determined in microsomes of liver (RLMs), kidney (RRMs) and intestine (RIMs) from rats with colitis at acute (5% DSS for 7 days, UCA) and remission (7-day DSS treatment followed by 7-day cessation, UCR) phases and compared with normal rats. Generally, CYPs activities varied with isoform, organ, and disease status...
June 1, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28436861/uncorrelated-component-analysis-based-hashing
#18
Sungryull Sohn, Hyunwoo Kim, Junmo Kim
The approximate nearest neighbor (ANN) search problem is important in applications such as information retrieval. Several hashing-based search methods that provide effective solutions to the ANN search problem have been proposed. However, most of these focus on similarity preservation and coding error minimization, and pay little attention to optimizing the precision-recall curve or receiver operating characteristic curve. In this paper, we propose a novel projection-based hashing method that attempts to maximize precision and recall...
April 18, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28428448/unruptured-cerebral-aneurysms-in-elderly-patients
#19
Tomohito Hishikawa, Isao Date
The prevalence of unruptured cerebral aneurysms (UCAs) in elderly patients is increasing in our aging population. UCA management in elderly patients has some difficulties, such as reduced life expectancy, increased comorbidities and treatment risks, and poor prognosis in case of rupture. In this review article, we summarize the most recent findings on the natural history, therapeutic options and treatment results for UCAs exclusively in elderly patients, and describe possible medical treatments for patients with UCAs...
April 19, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28405396/multimodal-communication-in-courting-fiddler-crabs-reveals-male-performance-capacities
#20
Sophie L Mowles, Michael Jennions, Patricia R Y Backwell
Courting males often perform different behavioural displays that demonstrate aspects of their quality. Male fiddler crabs, Uca sp., are well known for their repetitive claw-waving display during courtship. However, in some species, males produce an additional signal by rapidly stridulating their claw, creating a 'drumming' vibrational signal through the substrate as a female approaches, and even continue to drum once inside their burrow. Here, we show that the switch from waving to drumming might provide additional information to the female about the quality of a male, and the properties of his burrow (multiple message hypothesis)...
March 2017: Royal Society Open Science
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