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Gustavo J Bondulich
This is a report of the first three days Uniportal VATS International Meeting. The conference included oral presentations at the Universidad Catolica Argentina (UCA), on the first day. Live Surgery from Shanghai Pulmonary Hospital, Tongji University, China, and Clinica San Camilo. Bs As, Argentina on the second day and a Wet lab in Fundación Triada Mininvasiva, Fatima Pilar on the final day.
2018: Journal of Visualized Surgery
Tian Zhou, Wenbin Cai, Hengli Yang, Huizhong Zhang, Minghua Hao, Lijun Yuan, Jie Liu, Li Zhang, Yilin Yang, Xi Liu, Jianling Deng, Ping Zhao, Guodong Yang, Yunyou Duan
In vivo assessment of apoptotic response to cancer therapy is believed to be very important for optimizing management of treatment. However, few noninvasive strategies are currently available to monitor the therapeutic response in vivo. Ultrasonography has been used to detect apoptotic cell death in vivo, but a high-frequency transducer is needed. Fortunately, the capability of ultrasound contrast agents (UCAs) to exit the leaky vasculature of tumors enables ultrasound-targeted imaging of molecular events in response to cancer therapy...
March 6, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Wui K Chong, Virginie Papadopoulou, Paul A Dayton
Microbubble ultrasound contrast agents (UCAs) were recently approved by the Food and Drug administration for non-cardiac imaging. The physical principles of UCAs, methods of administration, dosage, adverse effects, and imaging techniques both current and future are described. UCAs consist of microbubbles in suspension which strongly interact with the ultrasound beam and are readily detectable by ultrasound imaging systems. They are confined to the blood pool when administered intravenously, unlike iodinated and gadolinium contrast agents...
March 5, 2018: Abdominal Radiology
Jing Du, Xiao-Yu Li, He Hu, Li Xu, Shi-Ping Yang, Feng-Hua Li
Molecularly-targeted contrast enhanced ultrasound (US) imaging is a promising imaging strategy with large potential for improving diagnostic accuracy of conventional US imaging in breast cancer detection. Therefore, we constructed a novel dual-targeted nanosized US contrast agent (UCA) directed at both vascular endothelial growth factor receptor 2 (VEGFR2) and human epidermal growth factor receptor 2 (HER2) based on perfluoropropane (C3 F8 )-filled poly(lactic-co-glycolic acid) (PLGA) (NBs) for breast cancer detection...
March 1, 2018: Scientific Reports
Leigh M Damare, Kristin N Bridges, Matthew M Alloy, Thomas E Curran, Brianne K Soulen, Heather P Forth, Claire R Lay, Jeffrey M Morris, James A Stoeckel, Aaron P Roberts
The 2010 explosion of the Deepwater Horizon (DWH) oil rig led to the release of millions of barrels of oil in the Gulf of Mexico. Oil in aquatic ecosystems exerts toxicity through multiple mechanisms, including photo-induced toxicity following co-exposure with UV radiation. The timing and location of the spill coincided with both fiddler crab reproduction and peak yearly UV intensities, putting early life stage fiddler crabs at risk of injury due to photo-induced toxicity. The present study assessed sensitivity of fiddler crab larvae to photo-induced toxicity during co-exposure to a range of environmentally relevant dilutions of high-energy water accommodated fractions of DWH oil, and either <10, 50, or 100% ambient sunlight, achieved with filters that allowed for variable UV penetration...
February 20, 2018: Ecotoxicology
L Tripto-Shkolnik, A Jaffe, Y Liel
Background: There is ample evidence associating vitamin D deficiency in primary hyperparathyroidism (PHP) patients with more severe disease manifestations and increased risk of postoperative hypocalcemia. Yet, there is limited data regarding the safety of vitamin D repletion in these patients. Aim: To assess the safety of vitamin D repletion in PHP patients in a real-world setting. Design: We included patients with asymptomatic PHP and few symptomatic patients who declined surgery, followed in our clinic, and treated on a routine basis with 2000 IU/day of vitamin D3...
February 1, 2018: QJM: Monthly Journal of the Association of Physicians
Ben Kumwenda, Jennifer Cleland, Rachel Greatrix, Rhoda Katharine MacKenzie, Gordon Prescott
INTRODUCTION: Attracting graduates was recommended as a means of diversifying the UK medical student population. Graduates now make up nearly a quarter of the total medical student population. Research to date has focused on comparing the sociodemographic characteristics of applicants to and/or students on traditional and graduate entry programmes (GEMs), yet GEMs account for only 40% of the graduate medical student population. Thus, we aimed to compare the sociodemographic characteristic and outcomes of graduates and non-graduate applicants across a range of programmes...
February 14, 2018: BMJ Open
Yidong Xu, Wenjing Shang, Lili Guo, Junwei Qi, Yingsong Li, Wei Xue
This article proposes a novel active localization method based on the mixed polarization multiple signal classification (MP-MUSIC) algorithm for positioning a metal target or an insulator target in the underwater environment by using a uniform circular antenna (UCA). The boundary element method (BEM) is introduced to analyze the boundary of the target by use of a matrix equation. In this method, an electric dipole source as a part of the locating system is set perpendicularly to the plane of the UCA. As a result, the UCA can only receive the induction field of the target...
February 11, 2018: Sensors
Christoph F Dietrich, Michalakis Averkiou, Michael Bachmann Nielsen, Richard G Barr, Peter N Burns, Fabrizio Calliada, Vito Cantisani, Byung Choi, Maria C Chammas, Dirk-André Clevert, Michel Claudon, Jean-Michel Correas, Xin-Wu Cui, David Cosgrove, Mirko D'Onofrio, Yi Dong, JohnR Eisenbrey, Teresa Fontanilla, Odd Helge Gilja, Andre Ignee, Christian Jenssen, Yuko Kono, Masatoshi Kudo, Nathalie Lassau, Andrej Lyshchik, Maria Franca Meloni, Fuminori Moriyasu, Christian Nolsøe, Fabio Piscaglia, Maija Radzina, Adrian Saftoiu, Paul S Sidhu, Ioan Sporea, Dagmar Schreiber-Dietrich, Claude B Sirlin, Maria Stanczak, Hans-Peter Weskott, Stephanie R Wilson, Juergen Karl Willmann, Tae Kyoung Kim, Hyun-Jung Jang, Alexandar Vezeridis, Sue Westerway
"How to perform contrast-enhanced ultrasound (CEUS)" provides general advice on the use of ultrasound contrast agents (UCAs) for clinical decision-making and reviews technical parameters for optimal CEUS performance. CEUS techniques vary between centers, therefore, experts from EFSUMB, WFUMB and from the CEUS LI-RADS working group created a discussion forum to standardize the CEUS examination technique according to published evidence and best personal experience. The goal is to standardise the use and administration of UCAs to facilitate correct diagnoses and ultimately to improve the management and outcomes of patients...
January 2018: Ultrasound International Open
Le Zuo, Jin Pan, Boyuan Ma
This paper presents an analytic algorithm for estimating three-dimensional (3-D) localization of a single source with uniform circular array (UCA) interferometers. Fourier transforms are exploited to expand the phase distribution of a single source and the localization problem is reformulated as an equivalent spectrum manipulation problem. The 3-D parameters are decoupled to different spectrums in the Fourier domain. Algebraic relations are established between the 3-D localization parameters and the Fourier spectrums...
February 6, 2018: Sensors
Kate Swanson, William A Grobman, Emily S Miller
OBJECTIVE:  Prediction of gestational latency after placement of physical exam indicated cerclage (PEIC) is limited. Uterocervical angle (UCA) has been associated with spontaneous preterm delivery in the general population. Our objective was to examine whether UCA is associated with gestational latency in women with PEIC. STUDY DESIGN:  This retrospective cohort included women with a singleton gestation who had PEIC placed at a single tertiary care center between January 2010 and September 2015...
January 24, 2018: American Journal of Perinatology
Sophie L Mowles, Michael D Jennions, Patricia R Y Backwell
Males often produce dynamic, repetitive courtship displays that can be demanding to perform and might advertise male quality to females. A key feature of demanding displays is that they can change in intensity: escalating as a male increases his signalling effort, but de-escalating as a signaller becomes fatigued. Here, we investigated whether female fiddler crabs, Uca mjoebergi, are sensitive to changes in male courtship wave rate. We performed playback experiments using robotic male crabs that had the same mean wave rate, but either escalated, de-escalated or remained constant...
January 2018: Biology Letters
Xiaolong Su, Zhen Liu, Xin Chen, Xizhang Wei
Due to its widespread application in communications, radar, etc., the orthogonal frequency division multiplexing (OFDM) signal has become increasingly urgent in the field of localization. Under uniform circular array (UCA) and near-field conditions, this paper presents a closed-form algorithm based on phase difference for estimating the three-dimensional (3-D) location (azimuth angle, elevation angle, and range) of the OFDM signal. In the algorithm, considering that it is difficult to distinguish the frequency of the OFDM signal's subcarriers and the phase-based method is always affected by errors of the frequency estimation, this paper employs sparse representation (SR) to obtain the super-resolution frequencies and the corresponding phases of subcarriers...
January 14, 2018: Sensors
Jacob M Taylor, Lyanne M Kieneker, Martin H de Borst, Sipke T Visser, Ido P Kema, Stephan J L Bakker, Ron T Gansevoort
Introduction: High urinary calcium excretion (UCaE) has been shown to lead to accelerated renal function decline in individuals with renal tubular diseases. It is not known whether this association also exists in the general population. Therefore, we investigated whether high UCaE is associated with risk of developing chronic kidney disease (CKD) in community-dwelling subjects. Methods: Urine samples of 5491 subjects who were free of CKD at baseline and participated in the Prevention of Renal and Vascular End-Stage Disease study (a prospective, observational, general population-based cohort of Dutch men and women aged 28-75 years) were examined for UCaE...
May 2017: KI Reports
Jesús Sánchez-Márquez, David Zorrilla, Víctor García, Manuel Fernández
In the present work, a new methodology defined for obtaining reactivity indices (philicities) is proposed. This is based on reactivity functions such as the Fukui function or the dual descriptor, and makes it possible to project the information from reactivity functions onto molecular orbitals, instead of onto the atoms of the molecule (atomic reactivity indices). The methodology focuses on the molecules' natural bond orbitals (bond reactivity indices) because these orbitals have the advantage of being localized, allowing the reaction site of an electrophile or nucleophile to be determined within a very precise molecular region...
December 22, 2017: Journal of Molecular Modeling
Guang-Qian Xiao, Mary M Barrett, Qi Yang, Pamela D Unger
Muscle invasive bladder cancer, an aggressive disease with heterogeneous molecular profiles, has recently been subclassified into three major molecular subtypes -basal, luminal and "p53-like" urothelial carcinomas (UCas), which bear prognostic and therapeutic implication. Similar to breast cancer, basal and luminal subtype UCas are designated by basal (CK5/14) and luminal (CK20) markers. The "p53-like" subtype presents with wild-type p53 gene with upregulated p53 pathways and is implicated in chemoresistance...
December 16, 2017: Pathology Oncology Research: POR
Bastian Joffroy, Yavuz O Uca, Domen Prešern, Jonathan P K Doye, Thorsten L Schmidt
Biophysical properties of DNA such as its longitudinal and torsional persistence length govern many processes and phenomena in biology, DNA nanotechnology and biotechnology. It has, for example, long been known that the circularization efficiency of short DNA fragments shows a periodic pattern where fragments with integer helical turns circularize much more efficiently than those with odd helical half turns due to stronger stacking of duplex ends. Small DNA circles can serve as templates for rolling circle amplification (RCA), which is a common and extremely robust amplification mechanism for nucleic acids...
December 9, 2017: Nucleic Acids Research
Er-Jiao Xu, Man Zhang, Kai Li, Zhong-Zhen Su, Ying-Lin Long, Qing-Jin Zeng, Huan-Yi Guo, Rong-Qin Zheng
The goal of this study was to investigate intracavitary contrast-enhanced ultrasound (IC-CEUS) measures in the management of post-surgical gastrointestinal (GI) fistula throughout detection, treatment and follow-up. From June 2010 to August 2016, patients who were administered ultrasound contrast agent (UCA) via a drainage tube for IC-CEUS were enrolled and retrospectively analyzed. They were suspected of having GI anastomotic fistulas or had been found to have fluid collections with ultrasound that were accompanied by abdominal pain or fever after surgical procedures...
February 2018: Ultrasound in Medicine & Biology
Mustafa Zafer Temiz, Emrah Yuruk, Kasim Ertas, Oguzhan Zengi, Atilla Semercioz
PURPOSE: To investigate whether atorvastatin has favorable effects on urinary metabolic risk factors associated with urolithiasis. METHODS: Sixteen male Sprague-Dawley rats were randomly divided into two groups, and baseline spot and 24-h urine samples were collected. Distilled water and atorvastatin were administered to rats during 4 weeks in the control and atorvastatin groups, respectively. At the end of the experimental procedure, spot and 24-h urine samples were collected again...
February 2018: International Urology and Nephrology
Himanshu Shekhar, Nathaniel J Smith, Jason L Raymond, Christy K Holland
Physical characterization of an ultrasound contrast agent (UCA) aids in its safe and effective use in diagnostic and therapeutic applications. The goal of this study was to investigate the impact of temperature on the size distribution, shell properties, and stability of Definity® , a U.S. Food and Drug Administration-approved UCA used for left ventricular opacification. A Coulter counter was modified to enable particle size measurements at physiologic temperatures. The broadband acoustic attenuation spectrum and size distribution of Definity® were measured at room temperature (25 °C) and physiologic temperature (37 °C) and were used to estimate the viscoelastic shell properties of the agent at both temperatures...
February 2018: Ultrasound in Medicine & Biology
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