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https://www.readbyqxmd.com/read/28198322/nursingstandard-com
#1
(no author information available yet)
1 The number of applicants from England making at least one choice for a nursing course fell by 10,000, data released by the Universities and Colleges Admissions Service revealed. The RCN said it 'consistently warned' the government that removing the bursary would result in fewer applications. Read more: rcni.com/ucas-figures.
February 15, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28184060/do-high-tuition-fees-make-a-difference-characteristics-of-applicants-to-uk-medical-and-dental-schools-before-and-after-the-introduction-of-high-tuition-fees-in-2012
#2
J E Gallagher, A Calvert, V Niven, L Cabot
Aim To compare trends in the volume, socio-demography and academic experience of UK applicants and entrants to medicine and dentistry in the UK with university in general, before and after the major increase in university fees in England in 2012.Methods Descriptive trend analyses of University and College Admissions Services (UCAS) data for focused (preferred subject was medicine or dentistry) and accepted applicants, 2010-14, compared with university in general in relation to socio-demography (age, sex, ethnicity, POLAR 2, region) and academic experience (school type)...
February 10, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28182764/phylogenetic-patterns-and-the-adaptive-evolution-of-osmoregulation-in-fiddler-crabs-brachyura-uca
#3
Samuel Coelho Faria, Diogo Borges Provete, Carl Leo Thurman, John Campbell McNamara
Salinity is the primary driver of osmoregulatory evolution in decapods, and may have influenced their diversification into different osmotic niches. In semi-terrestrial crabs, hyper-osmoregulatory ability favors sojourns into burrows and dilute media, and provides a safeguard against hemolymph dilution; hypo-osmoregulatory ability underlies emersion capability and a life more removed from water sources. However, most comparative studies have neglected the roles of the phylogenetic and environmental components of inter-specific physiological variation, hindering evaluation of phylogenetic patterns and the adaptive nature of osmoregulatory evolution...
2017: PloS One
https://www.readbyqxmd.com/read/28113618/uniform-projection-for-multi-view-learning
#4
Zhenyue Zhang, Zheng Zhai, Limin Li
Multi-view learning aims to integrate multiple data information from different views to improve the learning performance. The key problem is to handle the unconformities or distortions among viewspecific samples or measurements of similarity or dissimilarity. This paper models the view-specific samples as a nonlinear mapping of uniform but latent intact samples for all the views, and the viewspecific dissimilarity matrices or similarity matrices are estimated in terms of the uniform latent one. Two methods are then developed for multi-view clustering...
August 19, 2016: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28113312/microbubble-composition-and-preparation-for-high-frequency-contrast-enhanced-ultrasound-imaging-in-vitro-and-in-vivo-evaluation
#5
Verya Daeichin, Tom van Rooij, Ilya Skachkov, Bulent Ergin, Patricia A C Specht, Alexandre Lima, Can Ince, Johan G Bosch, Antonius F W van der Steen, Nico de Jong, Klazina Kooiman
Although high-frequency ultrasound imaging is gaining attention in various applications, hardly any ultrasound contrast agents (UCAs) dedicated to such frequencies (>15 MHz) are available for contrast-enhanced ultrasound imaging (CEUS). Moreover, the composition of the limited commercially available UCAs for high-frequency CEUS (hfCEUS) is largely unknown, while shell properties have been shown to be an important factor for their performance. The aim of our study was to produce UCAs in-house for hfCEUS. Twelve different UCA formulations A-L were made by either sonication or mechanical agitation...
December 15, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28056806/suppression-of-experimental-autoimmune-encephalomyelitis-by-ultraviolet-light-is-not-mediated-by-isomerization-of-urocanic-acid
#6
Amy A Irving, Steven J Marling, Lori A Plum, Hector F DeLuca
BACKGROUND: Ultraviolet B irradiation confers strong resistance against experimental autoimmune encephalomyelitis, a model of multiple sclerosis. This protection by ultraviolet B is independent of vitamin D production but causes isomerization of urocanic acid, a naturally occurring immunosuppressant. METHODS: To determine whether UCA isomerization from trans to cis is responsible for the protection against experimental autoimmune encephalomyelitis afforded by ultraviolet B, trans- or cis-urocanic acid was administered to animals and their disease progression was monitored...
January 5, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28055026/anterior-uterocervical-angle-measurement-improves-prediction-of-cerclage-failure
#7
J C Knight, E Tenbrink, J Sheng, A S Patil
OBJECTIVE: To compare the anterior uterocervical angle and cervical length as predictors of spontaneous preterm delivery in patients with transvaginal cerclage. STUDY DESIGN: We retrospectively evaluated a cohort of 142 pregnant women with transvaginal cerclage placed over a 5-year period (2010 to 2015) were evaluated. Cervical morphology characteristics were measured from endovaginal imaging, including cervical length, cerclage height, funnel volume and anterior uterocervical angle prior to cerclage placement (UCA 1), shortly after cerclage placement (UCA 2) and the last image prior to delivery (UCA 3)...
January 5, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28052386/ecosystem-engineers-drive-creek-formation-in-salt-marshes
#8
Huy D Vu, Kazimierz Wie Ski, Steven C Pennings
Ecosystem engineers affect different organisms and processes in multiple ways at different spatial scales. Moreover, similar species may differ in their engineering effects for reasons that are not always clear. We examined the role of four species of burrowing crabs (Sesarma reticulatum, Eurytium limosum, Panopeus herbstii, Uca pugnax) in engineering tidal creek networks in salt marshes experiencing sea level rise. In the field, crab burrows were associated with heads of eroding creeks and the loss of plant (Spartina alterniflora) stems...
January 2017: Ecology
https://www.readbyqxmd.com/read/28050135/the-risk-of-colorectal-cancer-is-not-increased-after-a-diagnosis-of-urothelial-cancer-a-population-based-study
#9
C H Harlos, H Singh, Z Nugent, A Demers, S M Mahmud, P M Czaykowski
BACKGROUND: The data about whether patients with a prior urothelial cancer (uca) are at increased risk of colorectal cancer (crc) are conflicting. We used a competing risks analysis to determine the risk of crc after uca. METHODS: Historical cohorts were assembled by record linkage of Manitoba Cancer Registry and Manitoba Health databases. The incidence of crc for individuals with uca as their first cancer between 1987 and 2009 was compared with the incidence for randomly selected age-and sex-matched individuals without a cancer diagnosis at the index date (uca diagnosis date)...
December 2016: Current Oncology
https://www.readbyqxmd.com/read/28044473/synthesis-characterization-and-in-vitro-evaluation-of-targeted-gold-nanoshelled-poly-d-l-lactide-co-glycolide-nanoparticles-carrying-anti-p53-antibody-as-a-theranostic-agent-for-ultrasound-contrast-imaging-and-photothermal-therapy
#10
Li Xu, Caifeng Wan, Jing Du, Hongli Li, Xuesong Liu, Hong Yang, Fenghua Li
Breast cancer is the leading cause of cancer-related deaths in women and earlier detection can substantially reduce deaths from breast cancer. Polymers with targeted ligands are widely used in the field of molecular ultrasound imaging and targeted tumor therapy. In our study, the nanotheranostic agent was fabricated through filling perfluoropropane (C3F8) into poly(d,l-lactic-co-glycolic acid) nanoparticles (PLGA NPs), followed by the formation of gold nanoshell on the surface, then conjugated with anti p53 antibody which has high specificity with the p53 protein overexpressing in breast cancer...
January 16, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28000971/safety-and-tolerability-of-sonovue%C3%A2-in-patients-with-large-artery-anterior-circulation-acute-stroke
#11
Claudio Baracchini, Federica Viaro, Silvia Favaretto, Anna Palmieri, Caterina Kulyk, Francesco Causin, Filippo Farina, Enzo Ballotta
BACKGROUND AND PURPOSE: Ultrasound contrast agents (UCAs) are routinely used to improve the visualization of intracranial arteries. Since a higher rate of intracranial hemorrhage (ICH) has been observed in patients undergoing sonothrombolysis in combination with UCAs, we conducted this study with the aim of assessing safety and tolerability of SonoVue® in patients with acute ischemic stroke due to anterior circulation large artery occlusion (LAO) and eligible to intravenous thrombolysis and/or mechanical thrombectomy...
December 21, 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/27990422/premature-destruction-of-microbubbles-during-voiding-urosonography-in-children-and-possible-underlying-mechanisms-post-hoc-analysis-from-the-prospective-study
#12
Maciej Piskunowicz, Dominik Swieton, Dorota Rybczynska, Arkadiusz Szarmach, Edyta Szurowska, Menno Pruijm
The aim of this study is to describe premature microbubbles destruction with contrast-enhanced voiding urosonography (ce-VUS) in children using 2nd-generation ultrasound contrast agents (UCA) and to hypothesize about the reason. 141 children (61 females and 80 males) were included in the study, with mean age of 3.3 years (range 4 weeks-16.0 years), who underwent ce-VUS examination between 2011 and 2014. Premature destruction of the microbubbles in the urinary bladder during ce-VUS was observed in 11 children (7...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27916815/changes-in-biochemical-parameters-of-the-calcium-phosphorus-homeostasis-in-relation-to-nutritional-intake-in-very-low-birth-weight-infants
#13
Viola Christmann, Charlotte J W Gradussen, Michelle N Körnmann, Nel Roeleveld, Johannes B van Goudoever, Arno F J van Heijst
Preterm infants are at significant risk to develop reduced bone mineralization based on inadequate supply of calcium and phosphorus (Ca-P). Biochemical parameters can be used to evaluate the nutritional intake. The direct effect of nutritional intake on changes in biochemical parameters has not been studied. Our objective was to evaluate the effect of Ca-P supplementation on biochemical markers as serum (s)/urinary (u) Ca and P; alkaline phosphatase (ALP); tubular reabsorption of P (TrP); and urinary ratios for Ca/creatinin (creat) and P/creatinin in Very-Low-Birth-Weight infants on Postnatal Days 1, 3, 5, 7, 10, and 14...
November 29, 2016: Nutrients
https://www.readbyqxmd.com/read/27914983/neuropeptide-y-y1-receptor-mediated-biodegradable-photoluminescent-nanobubbles-as-ultrasound-contrast-agents-for-targeted-breast-cancer-imaging
#14
Juan Li, Yuchen Tian, Dingying Shan, An Gong, Leyong Zeng, Wenzhi Ren, Lingchao Xiang, Ethan Gerhard, Jinshun Zhao, Jian Yang, Aiguo Wu
Targeted molecular imaging has attracted great attention in cancer diagnosis and treatment. However, most clinically used ultrasound contrast agents (UCAs) are non-targeted microbubbles seldom used for cancer imaging. Here, we fabricated fluorescent nanobubbles (NBs) by encapsulation of liquid tetradecafluorohexane (C6F14) within biodegradable photoluminescent polymers (BPLPs) through an emulsion-evaporation process and conjugation of PNBL-NPY ligand for specific targeting of Y1 receptors overexpressed in breast tumors...
February 2017: Biomaterials
https://www.readbyqxmd.com/read/27901181/evaluation-of-preoperative-ultrasonographic-and-biochemical-features-of-patients-with-aggressive-parathyroid-disease-is-there-a-reliable-predictive-marker
#15
Bekir Cakir, Sefika Burcak Polat, Mehmet Kilic, Didem Ozdemir, Cevdet Aydin, Nuran Süngü, Reyhan Ersoy
Objective: Parathyroid cancer (PC) represents < 1% of cases of PHPT. Tumors demonstrating atypical histopathologic features and don't fulfill criteria for carcinoma are classified as atypical adenomas (APA). The purpose of this study was to determine a biochemical or ultrasonographic feature that can predict aggressive disease requiring more extensive surgery and closer follow-up. Subjects and methods: Twenty eight patients operated for PHPT and diagnosed with atypical adenoma (23 patients) or carcinoma (5 patients) were enrolled in this study...
November 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27896329/myasthenia-gravis-with-acute-respiratory-failure-in-the-emergency-department
#16
Hasan Huseyin Kozak, Ali Ulvi Uca, Turgut Teke, Mustafa Altas, Emine Karatas
Acute respiratory failure (ARF) is defined as a sudden malfunction in the ability of respiratory system to maintain adequate gas exchange. Acute hypercapnic respiratory failure develops as a result of ventilation deficiency and it is defined as an increase of PaCO2 above 45 mmHg. Myasthenia Gravis (MG) is a sporadically developing auto-immune deficiency where the neuro-muscular transmission is affected and it is one of the important reasons for neurologically-induced respiratory distress. Here, we report a case of a 75-year-old male patient previously undiagnosed MG, who presented with ARF...
June 2016: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27892760/microbubble-mediated-ultrasound-drug-delivery-and-therapeutic-monitoring
#17
Charles A Sennoga, Emma Kanbar, Laurent Auboire, Paul-Armand Dujardin, Damien Fouan, Jean-Michel Escoffre, Ayache Bouakaz
Recent developments in ultrasound imaging and ultrasound contrast agents (UCAs) improved diagnostic confidence in echography and set into motion their combined use as a tool for drug delivery and therapeutic monitoring. Non-invasive, precise and targeted delivery of drug molecules to pathological tissues by employing different mechanisms of drug release is becoming feasible. Areas covered: We sought to describe: the nature and features of UCAs; outline current contrast-specific imaging modes; before describing a variety of strategies for using ultrasound and microbubbles as a drug delivery system...
December 11, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27860550/contrast-enhanced-us-guided-interventions-improving-success-rate-and-avoiding-complications-using-us-contrast-agents
#18
Dean Y Huang, Gibran T Yusuf, Mohammad Daneshi, Mohammad Ali Husainy, Raymond Ramnarine, Maria E K Sellars, Paul S Sidhu
Ultrasonography (US) is an established modality for intervention. The introduction of microbubble US contrast agents (UCAs) has the potential to further improve US imaging for intervention. According to licensing, UCAs are currently approved for clinical use in restricted situations, but many additional indications have become accepted as having clinical value. The use of UCAs has been shown to be safe, and there is no risk of renal toxic effects, unlike with iodinated or gadolinium contrast medium. Broadly speaking, UCAs can be injected into the bloodstream (intravascular use) or instilled into almost any accessible body cavity (endocavitary use), either in isolation or synchronously...
November 18, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27858294/sleep-quality-morningness-eveningness-preference-mood-profile-and-levels-of-serum-melatonin-in-migraine-patients-a-case-control-study
#19
Hasan Hüseyin Kozak, Murat Boysan, Ali Ulvi Uca, Adem Aydın, İbrahim Kılınç, Emine Genç, Mustafa Altaş, Dilara Cari Güngör, Keziban Turgut, Nejla Özer
The melatonin as the pineal gland's secretory product is implicated in the pathophysiology of migraine. Melatonin has critical functions in human physiology, and research underscores the importance of melatonin in circadian rhythm, sleep, and mood regulation. Clinical observations have indicated that migraine attacks have a seasonal, menstrual, and circadian timing, suggesting that chronobiological mechanisms and their alterations may causally involve in the etiology of the disease. However, the topic has received relatively little attention in the migraine literature...
November 17, 2016: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/27836683/fiddler-crabs-uca-spp-as-model-hosts-for-laboratory-infections-of-hematodinium-perezi
#20
Patricia A O'Leary, Jeffrey D Shields
The parasitic dinoflagellate, Hematodinium perezi, negatively impacts the commercially important blue crab, Callinectes sapidus. The parasite is a host generalist, but it has not been reported from littoral fiddler crabs living within a few meters of habitat known to harbor infected blue crabs. In the first study, populations of three species of fiddler crab were screened for natural infections. The infection status of field-collected and lab-inoculated crabs was determined by screening fresh hemolymph with a 0...
November 9, 2016: Journal of Invertebrate Pathology
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