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https://www.readbyqxmd.com/read/28822698/staphylococcus-aureus-from-atopic-dermatitis-skin-alters-cytokine-production-triggered-by-monocyte-derived-langerhans-cell
#1
Kazumasa Iwamoto, Masaya Moriwaki, Yoshie Niitsu, Masachika Saino, Shunsuke Takahagi, Junzo Hisatsune, Motoyuki Sugai, Michihiro Hide
BACKGROUND: Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases. The skin of patients with AD presents as a disbalance of the microbiome with a strong colonization by Staphylococcus aureus, which positively correlates with the severity of the disease. However, the effect of colonized S. aureus on the skin immune system has not been fully elucidated. OBJECTIVE: The aim of this study is to explore whether S. aureus isolated from AD skin is able to skew T cell responses via Langerhans cells (LC) as compared to a standard strain of S...
August 5, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28814567/cbf%C3%AE-2-deficiency-preserves-langerhans-cell-precursors-by-lack-of-selective-tgf%C3%AE-receptor-signaling
#2
Mari Tenno, Katsuyuki Shiroguchi, Sawako Muroi, Eiryo Kawakami, Keita Koseki, Kirill Kryukov, Tadashi Imanishi, Florent Ginhoux, Ichiro Taniuchi
The mouse Langerhans cell (LC) network is established through the differentiation of embryonic LC precursors. BMP7 and TGFβ1 initiate cellular signaling that is essential for inducing LC differentiation and preserving LCs in a quiescent state, respectively. Here we show that loss of Cbfβ2, one of two RNA splice variants of the Cbfb gene, results in long-term persistence of embryonic LC precursors after their developmental arrest at the transition into the EpCAM(+) stage. This phenotype is caused by selective loss of BMP7-mediated signaling essential for LC differentiation, whereas TGFβR signaling is intact, maintaining cells in a quiescent state...
August 16, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28807051/mesenchymal-stromal-cells-ameliorate-oxidative-stress-induced-islet-endothelium-apoptosis-and-functional-impairment-via-wnt4-%C3%AE-catenin-signaling
#3
Lingshu Wang, Li Qing, He Liu, Na Liu, Jingting Qiao, Chen Cui, Tianyi He, Ruxing Zhao, Fuqiang Liu, Fei Yan, Chuan Wang, Kai Liang, Xinghong Guo, Ying H Shen, Xinguo Hou, Li Chen
BACKGROUND: Islet dysfunction and destruction are the common cause for both type 1 and type 2 diabetes mellitus (T2DM). The islets of Langerhans are highly vascularized miniorgans, and preserving the structural integrity and full function of the microvascular endothelium is vital for protecting the islets from the infiltration of immune cells and secondary inflammatory attack. Mesenchymal stromal cell (MSC)-based therapies have been proven to promote angiogenesis of the islets; however, the underlying mechanism for the protective role of MSCs in the islet endothelium is still vague...
August 14, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28803660/multiple-sclerosis-skin-induced-antigen-specific-immune-tolerance
#4
REVIEW
Paula Wildner, Krzysztof W Selmaj
Multiple sclerosis (MS) is a highly prevalent demyelinating disorder, presumed to be driven by an autoimmune response toward the central nervous system (CNS) components. All currently available treatments modulate the immune system globally and besides the reduction of disease activity, they may also impose considerable disturbances on the immune protective mechanisms. Thus, induction of antigen-specific immune tolerance remains the ultimate goal of MS therapy. Such approach carries promising therapeutic perspectives and, above all, a desirable safety profile...
August 2, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28802389/cholesteatoma-as-a-complication-of-langerhans-cell-histiocytosis-of-the-temporal-bone-a-nationwide-cross-sectional-analysis
#5
Jonathan C Simmonds, Mark Vecchiotti
OBJECTIVE: To determine if patients with Langerhans Cell Histiocytosis (LCH) of the temporal bone have a higher risk of developing cholesteatoma. METHODS: Review of literature and cross-sectional weighted analysis of patients under 19 with a diagnosis of LCH from the National Inpatient Sample (NIS) and Kids' Inpatient Database (KID) from 2000 to 2013. ICD-9 codes and demographics were analyzed; pairwise comparisons and multivariate analyses were performed. RESULTS: Only seven cases of cholesteatoma after the treatment for LCH of the temporal bone have been documented in the literature...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28797508/hematopoietic-tumors-primarily-presenting-in-bone
#6
REVIEW
Arjen H G Cleven, Pancras C W Hogendoorn
Hematologic neoplasms that primarily present in bone are rare; this article describes the most common examples of hematologic tumors primarily presenting in bone, including plasma cell myeloma, solitary plasmacytoma of bone, primary non-Hodgkin lymphoma of bone, acute lymphoblastic leukemia/lymphoma, and Langerhans cell histiocytosis. The macroscopic and microscopic features, differential diagnosis, diagnostic workup, and prognosis of all these different entities are discussed, with special emphasis on common differential diagnosis...
September 2017: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/28796320/congenital-cutaneous-lymphadenoma
#7
Angel Fernandez-Flores, Ina Nicklaus-Wollenteit, Dharshini Sathishkumar, Vicky Diba, Bruce Richard, Richard Carr, Celia Moss, Anita Nagy, Malobi Ogboli, Isabel Colmenero
Cutaneous lymphadenoma is an uncommon benign neoplasm often considered to be an adamantinoid variant of trichoblastoma. Lesions present in both sexes, between 14 and 87 years of age, and are mainly located on the head and neck. Cases in children are rare and there is only one previous case of a congenital lymphadenoma. An 8-year-old Asian girl presented with a congenital lesion on her forehead comprising four pink papules, the largest 5 mm in diameter. Microscopy revealed a well circumscribed tumor within the dermis and subcutis comprising well demarcated epithelial lobules of basaloid and clear cells with subtle peripheral palisading, growing in a collagenous stroma but lacking retraction artefact...
August 10, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28794143/differential-diagnosis-of-granulomatous-lung-disease-clues-and-pitfalls-number-4-in-the-series-pathology-for-the-clinician-edited-by-peter-dorfm%C3%A3-ller-and-alberto-cavazza
#8
Shinichiro Ohshimo, Josune Guzman, Ulrich Costabel, Francesco Bonella
Granulomatous lung diseases are a heterogeneous group of disorders that have a wide spectrum of pathologies with variable clinical manifestations and outcomes. Precise clinical evaluation, laboratory testing, pulmonary function testing, radiological imaging including high-resolution computed tomography and often histopathological assessment contribute to make a confident diagnosis of granulomatous lung diseases. Differential diagnosis is challenging, and includes both infectious (mycobacteria and fungi) and noninfectious lung diseases (sarcoidosis, necrotising sarcoid granulomatosis, hypersensitivity pneumonitis, hot tub lung, berylliosis, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, rheumatoid nodules, talc granulomatosis, Langerhans cell histiocytosis and bronchocentric granulomatosis)...
September 30, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28791997/-eosinophilic-granuloma-of-the-parietal-bone-of-an-adult-patient-with-braf-mutation
#9
O V Dolzhansky, E M Paltseva, A A Bukaeva, E V Zaklyazminskaya, I A Spivak, D N Fedorov
The paper describes a case of eosinophilic granuloma of the parietal bone in a 32-year-old man. Histological examination revealed a large number of bean-shaped Langerhans cell histiocytes with lobed nuclei and nuclear grooves. The histiocytes alternated with the foci of obvious eosinophilic infiltration and with eosinophilic microabscesses. There were osteoclast-like multinucleated giant cells, bone resorption, and numerous bone rods covered with osteoblast chains. The histiocytes expressed CD1α, langerin, CD68, S100, and p53 (in 90...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28777886/lower-levels-of-il-1%C3%AE-gene-expression-are-associated-with-impaired-langerhans-cell-migration-in-aged-human-skin
#10
Suzanne M Pilkington, Stephanie Ogden, Laura Eaton, Rebecca J Dearman, Ian Kimber, Christopher Em Griffiths
Langerhans' cells (LC) play pivotal roles in skin immune responses, linking innate and adaptive immunity. In aged skin there are fewer LC and migration is impaired compared with young skin. These changes may contribute to declining skin immunity in the elderly, including increased skin infections and skin cancer. Interleukin (IL)-1β and tumour necrosis factor (TNF)-α are mandatory signals for LC migration and previous studies suggest IL-1β signalling may be dysregulated in aged skin. Therefore, we sought to explore the mechanisms underlying these phenomena...
August 4, 2017: Immunology
https://www.readbyqxmd.com/read/28768873/human-herpesvirus-8-infects-and-replicates-in-langerhans-cells-and-interstitial-dermal-dendritic-cells-and-impairs-their-function
#11
Giovanna Rappocciolo, Mariel Jais, Paolo A Piazza, Diana C DeLucia, Frank J Jenkins, Charles R Rinaldo
The predominant types of dendritic cells (DC) in the skin and mucosa are Langerhans cells (LC) and interstitial dermal DC (iDDC). LC and iDDC process cutaneous antigens and migrate out of the skin and mucosa to the draining lymph nodes to present antigens to T and B cells. Because of the strategic location of LC and iDDC and the ability of these cells to capture and process pathogens, we hypothesized that they could be infected with human herpesvirus 8 (HHV-8; Kaposi's sarcoma-associated herpesvirus) and have an important role in the development of Kaposi's sarcoma (KS)...
August 2, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28767266/paul-langerhans-a-prilgrim-traveling-from-functional-histology-to-marine-biology
#12
REVIEW
Marius Raica, Anca Maria Cimpean
The nineteenth century was the time of a real revolution in science and medicine. A lot of seminal discoveries in medicine and biology were done in this time, and many of them were coincident with the introduction of the compound microscope by Hermann van Deijl and the standard histological technique by Paul Ehrlich. The main tissue types and individual cells were characterized and originally classified more than hundred years ago, although less attention was paid to their basic functions. This was mainly due to the modality of tissue specimen processing that allowed particularly detailed descriptive studies...
June 2017: Acta Medico-historica Adriatica: AMHA
https://www.readbyqxmd.com/read/28766996/temporally-and-spatially-regulated-expression-of-the-linker-histone-h1fx-during-mouse-development
#13
Keiko Ichihara-Tanaka, Kenji Kadomatsu, Satoshi Kishida
The linker histone H1fx is the least characterized member of the H1 family. To investigate the developmental changes of H1fx, we performed an immunohistochemical analysis of its expression pattern from embryos to adult mice. We found that H1fx was highly expressed during gastrulation, and was positive in all embryonic germ layers between E8.5 and E10.5, which mostly overlapped with the expression of the proliferation marker Ki-67. Neural and mesenchyme tissues strongly expressed H1fx at E10.5. H1fx expression began to be restricted at around E12...
August 1, 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/28763212/cafestol-a-bioactive-substance-in-coffee-has-antidiabetic-properties-in-kkay-mice
#14
Fredrik Brustad Mellbye, Per Bendix Jeppesen, Pedram Shokouh, Christoffer Laustsen, Kjeld Hermansen, Søren Gregersen
Daily coffee consumption is inversely associated with risk of type-2 diabetes (T2D). Cafestol, a bioactive substance in coffee, increases glucose-stimulated insulin secretion in vitro and increases glucose uptake in human skeletal muscle cells. We hypothesized that cafestol can postpone development of T2D in KKAy mice. Forty-seven male KKAy mice were randomized to consume chow supplemented daily with either 1.1 (high), 0.4 (low), or 0 (control) mg of cafestol for 10 weeks. We collected blood samples for fasting glucose, glucagon, and insulin as well as liver, muscle, and fat tissues for gene expression analysis...
August 1, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28762130/modelling-coupled-within-host-and-population-dynamics-of-formula-see-text-and-formula-see-text-hiv-infection
#15
Edna Chilenje Manda, Faraimunashe Chirove
Most existing models have considered the immunological processes occurring within the host and the epidemiological processes occurring at population level as decoupled systems. We present a new model using continuous systems of non linear ordinary differential equations by directly linking the within host dynamics capturing the interactions between Langerhans cells, CD4[Formula: see text] T-cells, R5 HIV and X4 HIV and the without host dynamics of a basic compartmental HIV/AIDS model. The model captures the biological theories of the cells that take part in HIV transmission...
July 31, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28761697/cardiorespiratory-fitness-and-physical-function-in-children-with-cancer-from-diagnosis-throughout-treatment
#16
Troels Thorsteinsson, Hanne Baekgaard Larsen, Kjeld Schmiegelow, Lone Friis Thing, Peter Krustrup, Mogens Theisen Pedersen, Karl Bang Christensen, Pernille Rudebeck Mogensen, Anne Sofie Helms, Lars Bo Andersen
BACKGROUND: Children with cancer experience severe reductions in physical fitness and functionality during and following intensive treatment. This may negatively impact their quality of life. PURPOSE: To describe the physical capacity and functionality of children with cancer during and after treatment as well as the feasibility of physical activity intervention in the Rehabilitation including Social and Physical activity and Education in Children and Teenagers with Cancer study...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28759391/case-report-of-a-hypobaric-chamber-fitness-to-fly-test-in-a-child-with-severe-cystic-lung-disease
#17
Sarah Loo, Andrew Campbell, Julian Vyas, Naveen Pillarisetti
Patients with severe cystic lung disease are considered to be at risk for cyst rupture during air travel because of the possibility of increase in cyst size and impaired equilibration of pressure between the cysts and other parts of the lung. This may have clinically devastating consequences for the patient but may also result in significant costs for emergency alteration of flight schedule. We report the use of a hypobaric chamber to simulate cabin pressure changes encountered on a commercial flight to assess the safety to fly of a child with severe cystic lung disease secondary to Langerhans cell histiocytosis...
July 2017: Pediatrics
https://www.readbyqxmd.com/read/28757768/langerhans-cell-histiocytosis-of-the-bone
#18
Wen-Chih Huang, Ta-Pin Lee, Min-En Chou, Chien-Chen Tsai
No abstract text is available yet for this article.
January 2017: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/28757697/corneal-ring-infiltration-in-contact-lens-wearers
#19
Seyed Ali Tabatabaei, Mohammad Soleimani, Mohammadkarim Johari
To report a case of atypical sterile ring infiltrates during wearing soft silicone hydrogel contact lens due to poor lens care. A 29-year-old woman presented with complaints of pain, redness, and morning discharge. She was wearing soft silicone hydrogel contact lens previously; her current symptoms began 1 week before presentation. On examination, best-corrected visual acuity was 20/40 in that eye. Slit-lamp examination revealed dense, ring-shaped infiltrate involving both the superficial and deep stromal layers with lucid interval to the limbus, edema of the epithelium, epithelial defect, and vascularization of the superior limbus...
May 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28757081/geographic-tongue-assessment-of-peripheral-nerve-status-langerhans-cell-and-hla-dr-expression
#20
Mark Roger Darling, Nan Su, Sherry Masen, Paul Kwon, Daniel Fortino, Taylor McKerlie, Miriam Grushka
OBJECTIVES: The objectives of this study were to determine whether geographic tongue (GT) is an antigen-driven condition by assessing Langerhans cell numbers and the expression of human leukocyte antigen (HLA)-DP, -DQ, and -DR in the epithelium of GT and to assess peripheral nerve status for any possible damage/injury association by quantifying neurite area in connective tissue in GT. STUDY DESIGN: Randomly selected samples of GT were examined by using routine immunoperoxidase staining methods to S100 protein, neurofilament, CD1a, and HLA class II...
June 7, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
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