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migratory Dendritic cells

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https://www.readbyqxmd.com/read/29229919/migratory-dendritic-cells-acquire-and-present-lymphatic-endothelial-cell-archived-antigens-during-lymph-node-contraction
#1
Ross M Kedl, Robin S Lindsay, Jeffrey M Finlon, Erin D Lucas, Rachel S Friedman, Beth A Jirón Tamburini
Antigens derived from viral infection or vaccination can persist within a host for many weeks after resolution of the infection or vaccine responses. We previously identified lymphatic endothelial cells (LEC) as the repository for this antigen archival, yet LECs are unable to present their archived antigens to CD8+ T cells, and instead transfer their antigens to CD11c+ antigen-presenting cells (APC). Here we show that the exchange of archived antigens between LECs and APCs is mediated by migratory dendritic cells (DC)...
December 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/29216332/voltage-dependent-calcium-channel-signaling-mediates-gabaa-receptor-induced-migratory-activation-of-dendritic-cells-infected-by-toxoplasma-gondii
#2
Sachie Kanatani, Jonas M Fuks, Einar B Olafsson, Linda Westermark, Benedict Chambers, Manuel Varas-Godoy, Per Uhlén, Antonio Barragan
The obligate intracellular parasite Toxoplasma gondii exploits cells of the immune system to disseminate. Upon T. gondii-infection, γ-aminobutyric acid (GABA)/GABAA receptor signaling triggers a hypermigratory phenotype in dendritic cells (DCs) by unknown signal transduction pathways. Here, we demonstrate that calcium (Ca2+) signaling in DCs is indispensable for T. gondii-induced DC hypermotility and transmigration in vitro. We report that activation of GABAA receptors by GABA induces transient Ca2+ entry in DCs...
December 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29196450/migratory-cd11b-conventional-dendritic-cells-induce-t-follicular-helper-cell-dependent-antibody-responses
#3
Jayendra Kumar Krishnaswamy, Uthaman Gowthaman, Biyan Zhang, Johan Mattsson, Louis Szeponik, Dong Liu, Renee Wu, Theresa White, Samuele Calabro, Lan Xu, Magalie A Collet, Marina Yurieva, Samuel Alsén, Per Fogelstrand, Anne Walter, William R Heath, Scott N Mueller, Ulf Yrlid, Adam Williams, Stephanie C Eisenbarth
T follicular helper (Tfh) cells are a subset of CD4+ T cells that promote antibody production during vaccination. Conventional dendritic cells (cDCs) efficiently prime Tfh cells; however, conclusions regarding which cDC instructs Tfh cell differentiation have differed between recent studies. We found that these discrepancies might exist because of the unusual sites used for immunization in murine models, which differentially bias which DC subsets access antigen. We used intranasal immunization as a physiologically relevant route of exposure that delivers antigen to all tissue DC subsets...
December 1, 2017: Science Immunology
https://www.readbyqxmd.com/read/29138056/skin-specific-cd301b-dermal-dendritic-cells-drive-il-17-mediated-psoriasis-like-immune-response-in-mice
#4
Tae-Gyun Kim, Sung Hee Kim, Jeyun Park, Wanho Choi, Moah Sohn, Hye Young Na, Minseok Lee, Jae Won Lee, Soo Min Kim, Do-Young Kim, Hyoung-Pyo Kim, Jae-Hoon Choi, Chae Gyu Park, Min-Geol Lee
Conventional dendritic cells (cDCs) are composed of heterogeneous subsets commonly arising from DC-committed progenitors. A population of CD301b-expressing DCs has recently been identified in non-lymphoid barrier tissues such as skin. However, whether CD301b(+) DCs in the skin represent ontogenetically unique subpopulation of migratory cDCs has not been fully addressed. Here, we demonstrated that CD301b(+) dermal DCs were distinct subpopulation of FLT3L-dependent CD11b(+) cDC2 lineage which required an additional GM-CSF cue for the adequate development...
November 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29118754/critical-role-of-plasmacytoid-dendritic-cells-in-regulating-gene-expression-and-innate-immune-responses-to-human-rhinovirus-16
#5
Yang Xi, Niamh M Troy, Denise Anderson, Olga M Pena, Jason P Lynch, Simon Phipps, Anthony Bosco, John W Upham
Though human rhinoviruses (HRVs) are usually innocuous viruses, they can trigger serious consequences in certain individuals, especially in the setting of impaired interferon (IFN) synthesis. Plasmacytoid dendritic cells (pDCs) are key IFN producing cells, though we know little about the role of pDC in HRV-induced immune responses. Herein, we used gene expression microarrays to examine HRV-activated peripheral blood mononuclear cells (PBMCs) from healthy people, in combination with pDC depletion, to assess whether observed gene expression patterns were pDC dependent...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29109732/ccl3-enhances-antitumor-immune-priming-in-the-lymph-node-via-ifn%C3%AE-with-dependency-on-natural-killer-cells
#6
Frederick Allen, Peter Rauhe, David Askew, Alexander A Tong, Joseph Nthale, Saada Eid, Jay T Myers, Caryn Tong, Alex Y Huang
Lymph node (LN) plays a critical role in tumor cell survival outside of the primary tumor sites and dictates overall clinical response in many tumor types (1, 2). Previously, we and others have demonstrated that CCL3 plays an essential role in orchestrating T cell-antigen-presenting cell (APC) encounters in the draining LN following vaccination, and such interactions enhance the magnitude of the memory T cell pool (3-5). In the current study, we investigate the cellular responses in the tumor-draining lymph nodes (TDLNs) of a CCL3-secreting CT26 colon tumor (L3TU) as compared to wild-type tumor (WTTU) during the priming phase of an antitumor response (≤10 days)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29091760/a-discrete-subset-of-monocyte-derived-cells-among-typical-conventional-type-2-dendritic-cells-can-efficiently-cross-present
#7
Jianpeng Sheng, Qi Chen, Irene Soncin, See Liang Ng, Klaus Karjalainen, Christiane Ruedl
Dendritic cells (DCs) and macrophages (Mϕs) share close developmental pathways and functional features, leading to blurring of the boundaries between these two cell lineages. However, a deeper understanding of DC and Mϕ ontogeny and more refined phenotypic and functional characterizations have helped to delineate pre-DC-derived conventional DCs (cDCs), including cDC1s and cDC2s, from monocyte-derived Mϕs. Here, we further refine DC/Mϕ cell classification and report that classically defined cDC2s contain a discrete population of monocyte-derived migratory antigen-presenting cells with Mϕ phenotype but functional DC features, including cross-presentation...
October 31, 2017: Cell Reports
https://www.readbyqxmd.com/read/29079750/skin-dendritic-cell-and-t-cell-activation-associated-with-dengue-shock-syndrome
#8
Huynh Thi Le Duyen, Daniela Cerny, Dinh The Trung, Jassia Pang, Sumathy Velumani, Ying Xiu Toh, Phan Tu Qui, Nguyen Van Hao, Cameron Simmons, Muzlifah Haniffa, Bridget Wills, Katja Fink
The pathogenesis of severe dengue remains unclear, particularly the mechanisms underlying the plasma leakage that results in hypovolaemic shock in a small proportion of individuals. Maximal leakage occurs several days after peak viraemia implicating immunological pathways. Skin is a highly vascular organ and also an important site of immune reactions with a high density of dendritic cells (DCs), macrophages and T cells. We obtained skin biopsies and contemporaneous blood samples from patients within 24 hours of onset of dengue shock syndrome (DSS), and from healthy controls...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29073194/change-in-the-immune-function-of-porcine-iliac-artery-endothelial-cells-infected-with-porcine-circovirus-type-2-and-its-inhibition-on-monocyte-derived-dendritic-cells-maturation
#9
Ning Yang, Jinzeng Qiao, Shiyu Liu, Zhanming Zou, Linlin Zhu, Xinyu Liu, Shuanghai Zhou, Huanrong Li
Porcine circovirus-associated disease is caused by porcine circovirus type 2 (PCV2) infection, which targets iliac artery endothelial cells (PIECs); it leads to severe immunopathologies and is associated with major economic losses in the porcine industry. Here, we report that in vitro PCV2 infection of PIECs causes cell injury, which affects DC function as well as adaptive immunity. Specifically, PCV2 infection downregulated PIEC antigen-presenting molecule expression, upregulated cytokines involved in the immune and inflammatory response causing cell damage and repair, and altered the migratory capacity of PIECs...
2017: PloS One
https://www.readbyqxmd.com/read/28935649/melanoma-sequentially-suppresses-different-dc-subsets-in-the-sentinel-lymph-node-affecting-disease-spread-and-recurrence
#10
Mari F C M van den Hout, Bas D Koster, Berbel J R Sluijter, Barbara G Molenkamp, Rieneke van de Ven, Alfons J M van den Eertwegh, Rik J Scheper, Paul A M van Leeuwen, M Petrousjka van den Tol, Tanja D de Gruijl
Melanoma exerts immune-suppressive effects to facilitate tumor progression and metastatic spread. We studied these effects on dendritic cell (DC) and T-cell subsets in 36 melanoma sentinel lymph node (SLN) from 28 stage I-III melanoma patients and determined their clinical significance. Four conventional DC subsets, plasmacytoid DCs, and CD4(+), CD8(+), and regulatory T cells (Tregs), were analyzed by flow cytometry. We correlated these data to clinical parameters and determined their effect on local and distant melanoma recurrence, with a median follow-up of 75 months...
September 21, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28917953/migratory-capacity-and-function-of-dendritic-cells-from-mesenteric-afferent-lymph-nodes-after-feeding-a-single-dose-of-vitamin-a
#11
Ivanna Novotny Nuñez, Bibiana E Barrios, Lisa Macció-Maretto, Silvia G Correa
Lamina propria dendritic cells (DCs) have a permanent turnover with constitutive migration to mesenteric lymph nodes and replenishment by progenitors. Luminal bacteria and dietary constituents provide key signals that endow DCs their unique properties in vivo. Taking into account that the intestinal immune system is greatly influenced by retinoids, we evaluated in B6 mice 3, 8, 16 and 24 h after feeding a single dose of vitamin A phenotype and function of cells present in mesenteric afferent lymph nodes as well as signals involved in migration...
November 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28865053/dc-sign-promotes-japanese-encephalitis-virus-transmission-from-dendritic-cells-to-t-cells-via-virological-synapses
#12
Ping Wang, Mei Li, Wei Lu, Di Zhang, Qinxue Hu, Yalan Liu
Skin-resident dendritic cells (DCs) likely encounter incoming viruses in the first place, and their migration to lymph nodes following virus capture may promote viral replication. However, the molecular mechanisms underlying these processes remain unclear. In the present study, we found that compared to cell-free viruses, DC-bound viruses showed enhanced capture of JEV by T cells. Additionally, JEV infection was increased by co-culturing DCs and T cells. Blocking the C-type lectin receptor DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) with neutralizing antibodies or antagonists blocked JEV transmission to T cells...
August 31, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28845904/spreading-the-load-antigen-transfer-between-migratory-and-lymph-node-resident-dendritic-cells-promotes-t-cell-priming
#13
Scott N Mueller
Dendritic cells (DC) are specialized in the processing and presentation of antigen for the activation of lymphocytes. Multiple subsets of DCs exist with distinct functions and roles in the initiation of immune responses. DCs found within tissues acquire antigens or become infected by pathogens and migrate to local draining lymph nodes (LN) where they can directly stimulate T cells. These migratory DCs can also transfer antigens to LN-resident DCs and may indirectly enhance T cell priming. In this issue of the European Journal of Immunology, Gurevich et al...
October 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28843293/langerhans-cells-orchestrate-tfh-dependent-humoral-immunity
#14
REVIEW
Trupti Vardam, Niroshana Anandasabapathy
T follicular helper cells contribute to the development of long-lasting humoral immunity by germinal center formation. Somatic hypermutation and affinity maturation take place in germinal centers leading to the generation of memory B cells and plasma cells. As such, T follicular helper cells impact immunodeficiencies, autoimmunity, and cancer. This necessitates further understanding of how T follicular helper cells are regulated in health and disease. The current study by Levin et al. builds on prior work to further substantiate a critical role for skin migratory dendritic cells and in particular Langerhans cells at governing T follicular helper and germinal center formation after intradermal immunization with HIV p24-coated polylactic acid nanoparticles...
September 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28833685/drebrin-e-regulates-neuroblast-proliferation-and-chain-migration-in-the-adult-brain
#15
Yuki Kajita, Nobuhiko Kojima, Noriko Koganezawa, Hiroyuki Yamazaki, Kenji Sakimura, Tomoaki Shirao
F-actin-binding protein drebrin has two major isoforms: drebrin A and drebrin E. Drebrin A is the major isoform in the adult brain and is highly concentrated in dendritic spines, regulating spine morphology and synaptic plasticity. Conversely, drebrin E is the major isoform in the embryonic brain and regulates neuronal morphological differentiation, but it is also expressed in neurogenic regions of the adult brain. The subventricular zone (SVZ) is one of the brain regions where adult neurogenesis occurs. Neuroblasts migrate to the olfactory bulb (OB) and integrate into existing neuronal networks, after which drebrin expression changes from E to A, suggesting that drebrin E plays a specific role in neuroblasts in the adult brain...
August 22, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28783680/arc-arg3-1-governs-inflammatory-dendritic-cell-migration-from-the-skin-and-thereby-controls-t-cell-activation
#16
Friederike Ufer, Pablo Vargas, Jan Broder Engler, Joseph Tintelnot, Benjamin Schattling, Hana Winkler, Simone Bauer, Nina Kursawe, Anne Willing, Oliver Keminer, Ora Ohana, Gabriela Salinas-Riester, Ole Pless, Dietmar Kuhl, Manuel A Friese
Skin-migratory dendritic cells (migDCs) are pivotal antigen-presenting cells that continuously transport antigens to draining lymph nodes and regulate immune responses. However, identification of migDCs is complicated by the lack of distinguishing markers, and it remains unclear which molecules determine their migratory capacity during inflammation. We show that, in the skin, the neuronal plasticity molecule activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) was strictly confined to migDCs...
September 23, 2016: Science Immunology
https://www.readbyqxmd.com/read/28777538/microinjection-for-the-ex-vivo-modification-of-cells-with-artificial-organelles
#17
Peter Tiefenboeck, Jong Ah Kim, Ferdinand Trunk, Tamara Eicher, Erica Russo, Alvaro Teijeira, Cornelia Halin, Jean-Christophe Leroux
Microinjection is extensively used across fields to deliver material intracellularly. Here we address the fundamental aspects of introducing exogenous organelles into cells to endow them with artificial functions. Nanocarriers encapsulating biologically active cargo or extreme intraluminal pH were injected directly into the cytosol of cells, where they bypassed subcellular processing pathways and remained intact for several days. Nanocarriers' size was found to dictate their intracellular distribution pattern upon injection, with larger vesicles adopting polarized agglomerated distributions and smaller colloids spreading evenly in the cytosol...
August 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28732748/controlling-the-pro-inflammatory-function-of-6-sulfo-lacnac-slan-dendritic-cells-with-dimethylfumarate
#18
Stephanie Oehrl, Florina Olaru, Anja Kunze, Michael Maas, Silvia Pezer, Marc Schmitz, Knut Schäkel
BACKROUND: The fumaric acid ester (FAE) dimethylfumarate (DMF) is a small molecule immunomodulator successfully used for the treatment of psoriasis and multiple sclerosis (MS). DMF is thought to inhibit pathogenic immune responses with Th17/Th1T cells, and IL-23/IL-12 producing dendritic cells (DCs). 6-sulfo LacNAc expressing dendritic cells (slanDCs) are a human pro-inflammatory cell type found frequently among the infiltrating leukocytes in skin lesions of psoriasis and brain lesions of MS...
June 24, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28710250/near-infrared-1064-nm-laser-modulates-migratory-dendritic-cells-to-augment-the-immune-response-to-intradermal-influenza-vaccine
#19
Kaitlyn Morse, Yoshifumi Kimizuka, Megan P K Chan, Mai Shibata, Yusuke Shimaoka, Shu Takeuchi, Benjamin Forbes, Christopher Nirschl, Binghao Li, Yang Zeng, Roderick T Bronson, Wataru Katagiri, Ayako Shigeta, Ruxandra F Sîrbulescu, Huabiao Chen, Rhea Y Y Tan, Kosuke Tsukada, Timothy Brauns, Jeffrey Gelfand, Ann Sluder, Joseph J Locascio, Mark C Poznansky, Niroshana Anandasabapathy, Satoshi Kashiwagi
Brief exposure of skin to near-infrared (NIR) laser light has been shown to augment the immune response to intradermal vaccination and thus act as an immunologic adjuvant. Although evidence indicates that the NIR laser adjuvant has the capacity to activate innate subsets including dendritic cells (DCs) in skin as conventional adjuvants do, the precise immunological mechanism by which the NIR laser adjuvant acts is largely unknown. In this study we sought to identify the cellular target of the NIR laser adjuvant by using an established mouse model of intradermal influenza vaccination and examining the alteration of responses resulting from genetic ablation of specific DC populations...
August 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28704477/comparative-phenotypic-and-functional-analysis-of-migratory-dendritic-cell-subsets-from-human-oral-mucosa-and-skin
#20
COMPARATIVE STUDY
Ilona Jennifer Kosten, Rieneke van de Ven, Maria Thon, Susan Gibbs, Tanja D de Gruijl
Antigen exposure to oral mucosa is generally thought to lead to immune tolerance induction. However, very little is known about the subset composition and function of dendritic cells (DC) migrating from human oral mucosa. Here we show that migratory DC from healthy human gingival explants consist of the same phenotypic subsets in the same frequency distribution as DC migrating from human skin. The gingival CD1a+ Langerhans cell and interstitial DC subsets lacked CXCR4 expression in contrast to their cutaneous counterparts, pointing to different migration mechanisms, consistent with previous observations in constructed skin and gingival equivalents...
2017: PloS One
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