keyword
MENU ▼
Read by QxMD icon Read
search

migratory Dendritic cells

keyword
https://www.readbyqxmd.com/read/28615266/antitumor-effects-of-epidrug-ifnalpha%C3%A2-combination-driven-by-modulated-gene-signatures-in-both-colorectal-cancer-and-dendritic-cells
#1
Alessandra Fragale, Giulia Romagnoli, Valerio Licursi, Maria Buoncervello, Giorgia Del Vecchio, Caterina Giuliani, Stefania Parlato, Celeste Leone, Marta De Angelis, Irene Canini, Elena Toschi, Filippo Belardelli, Rodolfo Negri, Imerio Capone, Carlo Presutti, Lucia Gabriele
Colorectal cancer (CRC) results from progressive accumulation of genetic and epigenetic alterations. IFN signaling defects play an important role in the carcinogenesis process, in which the inability of IFN transcription regulatory factors (IRFs) to access regulatory sequences in IFN-stimulated genes (ISGs) in tumors and in immune cells may be pivotal. We reported that low-dose combination of two FDA-approved epidrugs, azacytidine (A) and romidepsin (R), with IFNa2 (ARI) hampers the aggressiveness of both CRC metastatic and stem cells in vivo and triggers immunogenic cell death signals that stimulate dendritic cell (DC) function...
June 14, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28611779/diametric-role-of-the-latency-associated-protein-acr1-of-mycobacterium-tuberculosis-in-modulating-the-functionality-of-pre-and-post-maturational-stages-of-dendritic-cells
#2
Mohammed Amir, Mohammad Aqdas, Sajid Nadeem, Kaneez F Siddiqui, Nargis Khan, Javaid A Sheikh, Javed N Agrewala
It is instrumental for the Mycobacterium tuberculosis (Mtb) to persist within its host in dormancy. Mtb represses most of its metabolic machinery during latency, but upregulates the expression of latency-associated protein alpha-crystallin protein (Acr1). Therefore, it is imperative to understand how throughout dormancy, Mtb employs Acr1 to regulate the host immunity. This study reveals that Acr1 exhibits divergent effect on the pre- and post-maturation stages of dendritic cells (DCs). In the current study, we demonstrate that early encounter of bone marrow cells with Acr1 while differentiating into DCs (AcrDC(pre)), leads to impairment in their maturation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28596977/different-forms-of-structural-plasticity-in-the-adult-olfactory-bulb
#3
REVIEW
Delphine Hardy, Armen Saghatelyan
The adult olfactory bulb (OB) continuously receives new interneurons that integrate into the functional neuronal network and that play an important role in odor information processing and olfactory behavior. Adult neuronal progenitors are derived from neural stem cells in the subventricular zone (SVZ) bordering the lateral ventricle. They migrate long distances along the rostral migratory stream (RMS) toward the OB where they differentiate into interneurons, mature, and establish synapses with tufted or mitral cells (MC), the principal neurons in the OB...
2017: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/28590032/epithelial-mesenchymal-transition-in-cancer-metastasis-through-the-lymphatic-system
#4
REVIEW
Mikael C Karlsson, Santiago F Gonzalez, Josefin Welin, Jonas Fuxe
It was already in the 18th century when the French surgeon Le Dran first noted that breast cancer patients with spread of tumor cells to their axillary lymph nodes had a drastically worse prognosis than patients without spread (leDran et al., 1752). Since then, metastatic spread of cancer cells to regional lymph nodes has been established as the most important prognostic factor in many types of cancer (Carter et al., 1989; Elston and Ellis, 1991). However, despite its clinical importance, lymph metastasis remains an underexplored area of tumor biology...
June 7, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28588454/reelin-signaling-inactivates-cofilin-to-stabilize-the-cytoskeleton-of-migrating-cortical-neurons
#5
REVIEW
Michael Frotscher, Shanting Zhao, Shaobo Wang, Xuejun Chai
Neurons are highly polarized cells. They give rise to several dendrites but only one axon. In addition, many neurons show a preferred orientation. For example, pyramidal neurons of the cerebral cortex extend their apical dendrites toward the cortical surface while their axons run in opposite direction toward the white matter. This characteristic orientation reflects the migratory trajectory of a pyramidal cell during cortical development: the leading process (the future apical dendrite) extends toward the marginal zone (MZ) and the trailing process (the future axon) toward the intermediate zone (IZ) while the cells migrate radially to reach their destination in the cortical plate (CP)...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28515363/lung-cd103-dendritic-cells-restrain-allergic-airway-inflammation-through-il-12-production
#6
Laura Conejero, Sofía C Khouili, Sarai Martínez-Cano, Helena M Izquierdo, Paola Brandi, David Sancho
DCs are necessary and sufficient for induction of allergic airway inflammation. CD11b+ DCs direct the underlying Th2 immunity, but debate surrounds the function of CD103+ DCs in lung immunity and asthma after an allergic challenge. We challenged Batf3-/- mice, which lacked lung CD103+ DCs, with the relevant allergen house dust mite (HDM) as a model to ascertain their role in asthma. We show that acute and chronic HDM exposure leads to defective Th1 immunity in Batf3-deficient mice. In addition, chronic HDM challenge in Batf3-/- mice results in increased Th2 and Th17 immune responses and exacerbated airway inflammation...
May 18, 2017: JCI Insight
https://www.readbyqxmd.com/read/28515356/licensing-delineates-helper-and-effector-nk-cell-subsets-during-viral-infection
#7
Anthony E Zamora, Ethan G Aguilar, Can M Sungur, Lam T Khuat, Cordelia Dunai, G Raymond Lochhead, Juan Du, Claire Pomeroy, Bruce R Blazar, Dan L Longo, Jeffrey M Venstrom, Nicole Baumgarth, William J Murphy
Natural killer (NK) cells can be divided into phenotypic subsets based on expression of receptors that bind self-MHC-I molecules, a concept termed licensing or education. Here we show NK cell subsets with different migratory, effector, and immunoregulatory functions in dendritic cell and antigen (ag)-specific CD8+ T cell responses during influenza and murine cytomegalovirus infections. Shortly after infection, unlicensed NK cells localized in draining lymph nodes and produced GM-CSF, which correlated with the expansion and activation of dendritic cells, and resulted in greater and sustained ag-specific T cell responses...
May 18, 2017: JCI Insight
https://www.readbyqxmd.com/read/28457909/critical-role-for-skin-derived-migratory-dcs-and-langerhans-cells-in-tfh-and-gc-responses-after-intradermal-immunization
#8
Clément Levin, Olivia Bonduelle, Charles Nuttens, Charlotte Primard, Bernard Verrier, Alexandre Boissonnas, Béhazine Combadière
Intradermal (ID) delivery of antigen represents a potent route of immunization that involves multiple blood- and skin-derived dendritic cell (DC) sub-populations endowed with specialized functions and dynamics in their ability to prime naïve CD4+ T cells in the draining lymph node (DLN). Yet, their individual contributions to the generation of CD4+ T follicular helper (TFH) cells and germinal centers (GCs) remain to be understood. We found that ID immunization of mice with a particle-based vaccine induced robust TFH and GC B cell responses in skin DLNs, which were completely abrogated when skin cell emigration was prevented...
April 27, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28457871/dendritic-cells-interpret-haptotactic-chemokine-gradients-in-a-manner-governed-by-signal-to-noise-ratio-and-dependent-on-grk6
#9
Jan Schwarz, Veronika Bierbaum, Kari Vaahtomeri, Robert Hauschild, Markus Brown, Ingrid de Vries, Alexander Leithner, Anne Reversat, Jack Merrin, Teresa Tarrant, Tobias Bollenbach, Michael Sixt
Navigation of cells along gradients of guidance cues is a determining step in many developmental and immunological processes. Gradients can either be soluble or immobilized to tissues as demonstrated for the haptotactic migration of dendritic cells (DCs) toward higher concentrations of immobilized chemokine CCL21. To elucidate how gradient characteristics govern cellular response patterns, we here introduce an in vitro system allowing to track migratory responses of DCs to precisely controlled immobilized gradients of CCL21...
May 8, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28457810/chronic-stress-suppresses-anti-tumor-tcd8-responses-and-tumor-regression-following-cancer-immunotherapy-in-a-mouse-model-of-melanoma
#10
Annette Sommershof, Lisa Scheuermann, Julia Koerner, Marcus Groettrup
Animal tumor models and human cancer studies have provided convergent evidence that chronic psychological stress plays a decisive role in modulating anti-tumor T cell immunity. However, whether chronic stress also affects anti-cancer vaccine strategies that rely on the induction of functional tumor-specific TCD8+ cells has not been investigated yet. In this study we provide direct evidence that chronic stress suppresses the therapeutic efficacy of a biodegradable poly(d,l-lactide-co-glycolide) microsphere (PLGA-MS) based cancer vaccine in a murine melanoma model...
April 27, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28423181/mesenteric-lymph-node-cd11b-cd103-pd-l1-high-dendritic-cells-highly-induce-regulatory-t-cells
#11
Aya Shiokawa, Ryutaro Kotaki, Tomohiro Takano, Haruyo Nakajima-Adachi, Satoshi Hachimura
Dendritic cells (DCs) in mesenteric lymph nodes (MLNs) induce Foxp3(+) regulatory T cells to regulate immune responses to beneficial or non-harmful agents in the intestine, such as commensal bacteria and foods. Several studies in MLN DCs have revealed that the CD103(+) DC subset highly induces regulatory T cells, and another study has reported that MLN DCs from programmed death ligand 1 (PD-L1) -deficient mice could not induce regulatory T cells. Hence, the present study investigated the expression of these molecules on MLN CD11c(+) cells...
April 19, 2017: Immunology
https://www.readbyqxmd.com/read/28393074/adenovirus-mediated-ccr7-and-btla-overexpression-enhances-immune-tolerance-and-migration-in-immature-dendritic-cells
#12
Haiming Xin, Jinhong Zhu, Hongcheng Miao, Zhenyu Gong, Xiaochen Jiang, Xiaoyan Feng, Yalin Tong
Our previous report revealed that immature dendritic cells (imDCs) with adenovirus-mediated CCR7 overexpression acquired an enhanced migratory ability but also exhibited the lower immune tolerance observed in more mature cells. In the present study, we aimed to investigate whether BTLA overexpression was sufficient to preserve immune tolerance in imDCs with exogenous CCR7 overexpression. Scanning electron microscopy and surface antigens analysis revealed that BTLA overexpression suppressed DC maturation, an effect further potentiated in CCR7 and BTLA cooverexpressing cells...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28378805/neonatal-mice-possess-two-phenotypically-and-functionally-distinct-lung-migratory-cd103-dendritic-cell-populations-following-respiratory-infection
#13
T J Ruckwardt, K M Morabito, E Bar-Haim, D Nair, B S Graham
The CD103(+) subset of lung-migratory dendritic cells (DCs) plays an important role in the generation of CD8(+) T cell responses following respiratory infection. Here, we demonstrate that the dependence on CD103(+) DCs for stimulation of RSV-specific T cells is both epitope and age-dependent. CD103(+) DCs in neonatal mice develop two phenotypically and functionally distinct populations following respiratory infection. Neonatal CD103(+) DCs expressing low levels of CD103 (CD103lo DCs) and other lineage and maturation markers including costimulatory molecules are phenotypically immature and functionally limited...
April 5, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28364278/the-development-and-function-of-dendritic-cell-populations-and-their-regulation-by-mirnas
#14
REVIEW
Haibo Zhou, Li Wu
Dendritic cells (DCs) are important immune cells linking innate and adaptive immune responses. DCs encounter various self and non-self antigens present in the environment and induce different types of antigen specific adaptive immune responses. DCs can be classified into lymphoid tissue-resident DCs, migratory DCs, non-lymphoid resident DCs, and monocyte derived DCs (moDCs). Recent work has also established that DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function...
March 31, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28342908/intestinal-dendritic-cell-licensing-through-toll-like-receptor-4-is-required-for-oral-tolerance-in-patients-with-allergic-contact-dermatitis
#15
Feriel Hacini-Rachinel, Mercedes Gomez de Agüero, Reem Kanjarawi, Ludovic Moro-Sibilot, Jean-Benoit Le Luduec, Claire Macari, Gilles Boschetti, Emilie Bardel, Philippe Langella, Bertrand Dubois, Dominique Kaiserlian
BACKGROUND: Induction of oral tolerance to haptens is an efficient way to prevent allergic contact dermatitis (ACD) in mice. Toll-like receptor (TLR)-mediated sensing of the microbiota contributes to gut homeostasis, yet whether it contributes to induction of oral tolerance has not been documented. OBJECTIVE: We examined whether oral tolerance to the contact sensitizer 2,4-dinitro-fluorobenzene (DNFB) depends on microbiota/TLRs and evaluated the role of TLR4 on the tolerogenic function of intestinal dendritic cells (DCs)...
March 22, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28341057/histone-deacetylase-inhibitors-suppress-immature-dendritic-cell-s-migration-by-regulating-cc-chemokine-receptor-1-expression
#16
Young-Hoon Kim, Jae Kwon Lee
The modulation of immature dendritic cells (iDCs), which involves processes such as phagocytosis, migration, and maturation, is considered a beneficial research theme. Once activated by an antigen, iDCs turn to mature DCs (mDCs) and migrate towards secondary lymphoid organs, and initiate the progress of cellular immunity. Histone deacetylase inhibitors (HDACis) are also thought to be a major modulator of cellular immunity. Herein, we demonstrate that HDACis (trichostatin-A (TSA), sodium butylate (SB), scriptaid (ST)) play a central regulatory role in the migratory activity of iDCs...
February 28, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28329707/dendritic-cells-display-subset-and-tissue-specific-maturation-dynamics-over-human-life
#17
Tomer Granot, Takashi Senda, Dustin J Carpenter, Nobuhide Matsuoka, Joshua Weiner, Claire L Gordon, Michelle Miron, Brahma V Kumar, Adam Griesemer, Siu-Hong Ho, Harvey Lerner, Joseph J C Thome, Thomas Connors, Boris Reizis, Donna L Farber
Maturation and migration to lymph nodes (LNs) constitutes a central paradigm in conventional dendritic cell (cDC) biology but remains poorly defined in humans. Using our organ donor tissue resource, we analyzed cDC subset distribution, maturation, and migration in mucosal tissues (lungs, intestines), associated lymph nodes (LNs), and other lymphoid sites from 78 individuals ranging from less than 1 year to 93 years of age. The distribution of cDC1 (CD141(hi)CD13(hi)) and cDC2 (Sirp-α(+)CD1c(+)) subsets was a function of tissue site and was conserved between donors...
March 21, 2017: Immunity
https://www.readbyqxmd.com/read/28329699/of-human-dc-migrants-and-residents
#18
Elodie Segura, Vassili Soumelis
Migration from peripheral tissues to lymph nodes is a key feature of dendritic cells (DCs), but little is known about the migration patterns of human DCs. By analyzing multiple lymphoid organs and tissues from the same donors, Granot et al. propose that the two main subsets of human DCs display different migratory capacity.
March 21, 2017: Immunity
https://www.readbyqxmd.com/read/28291135/depletion-of-epidermal-langerhans-cells-in-the-skin-lesions-of-pellagra-patients
#19
Sayaka Yamaguchi, Takuya Miyagi, Yoko Sogabe, Masahito Yasuda, Nobuo Kanazawa, Atsushi Utani, Seiichi Izaki, Hiroshi Uezato, Kenzo Takahashi
Pellagra is a nutrient deficiency disease caused by insufficient niacin levels. Recent studies have shown that numbers of epidermal Langerhans cells decreased in other diseases caused by nutritional deficiencies, including necrolytic migratory erythema and acrodermatitis enteropathica. Epidermal Langerhans cells are capable of modulating or even halting the inflammatory reaction. The aim of this study was to examine changes in the number of Langerhans cells and other dendritic cells, and maturation of epidermal Langerhans cells in the lesional and adjacent non-lesional skin in pellagra patients...
June 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28276533/immunogenicity-is-preferentially-induced-in-sparse-dendritic-cell-cultures
#20
Aikaterini Nasi, Vishnu Priya Bollampalli, Meng Sun, Yang Chen, Sylvie Amu, Susanne Nylén, Liv Eidsmo, Antonio Gigliotti Rothfuchs, Bence Réthi
We have previously shown that human monocyte-derived dendritic cells (DCs) acquired different characteristics in dense or sparse cell cultures. Sparsity promoted the development of IL-12 producing migratory DCs, whereas dense cultures increased IL-10 production. Here we analysed whether the density-dependent endogenous breaks could modulate DC-based vaccines. Using murine bone marrow-derived DC models we show that sparse cultures were essential to achieve several key functions required for immunogenic DC vaccines, including mobility to draining lymph nodes, recruitment and massive proliferation of antigen-specific CD4+ T cells, in addition to their TH1 polarization...
March 9, 2017: Scientific Reports
keyword
keyword
76361
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"