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migratory Dendritic cells

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https://www.readbyqxmd.com/read/28423181/mesenteric-lymph-node-cd11b-cd103-pd-l1-high-dendritic-cells-highly-induce-regulatory-t-cells
#1
Aya Shiokawa, Ryutaro Kotaki, Tomohiro Takano, Haruyo Nakajima-Adachi, Satoshi Hachimura
Dendritic cells (DCs) in mesenteric lymph nodes (MLNs) induce Foxp3(+) regulatory T cells to regulate immune responses to beneficial or non-harmful agents in the intestine, such as commensal bacteria and foods. Several studies in MLN DCs have revealed that CD103(+) DC subset highly induces regulatory T cells, and another study has reported that MLN DCs from PD-L1-deficient mice could not induce regulatory T cells. Thus, the present study investigated expression of these molecules on MLN CD11c(+) cells. Four distinct subsets expressing CD103 and/or PD-L1 were identified, namely CD11b(+) CD103(+) PD-L1(High) , CD11b(-) CD103(+) PD-L1(High) , CD11b(-) CD103(+) PD-L1(Low) , and CD11b(+) CD103(-) PD-L1(Int...
April 19, 2017: Immunology
https://www.readbyqxmd.com/read/28393074/adenovirus-mediated-ccr7-and-btla-overexpression-enhances-immune-tolerance-and-migration-in-immature-dendritic-cells
#2
Haiming Xin, Jinhong Zhu, Hongcheng Miao, Zhenyu Gong, Xiaochen Jiang, Xiaoyan Feng, Yalin Tong
Our previous report revealed that immature dendritic cells (imDCs) with adenovirus-mediated CCR7 overexpression acquired an enhanced migratory ability but also exhibited the lower immune tolerance observed in more mature cells. In the present study, we aimed to investigate whether BTLA overexpression was sufficient to preserve immune tolerance in imDCs with exogenous CCR7 overexpression. Scanning electron microscopy and surface antigens analysis revealed that BTLA overexpression suppressed DC maturation, an effect further potentiated in CCR7 and BTLA cooverexpressing cells...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28378805/neonatal-mice-possess-two-phenotypically-and-functionally-distinct-lung-migratory-cd103-dendritic-cell-populations-following-respiratory-infection
#3
T J Ruckwardt, K M Morabito, E Bar-Haim, D Nair, B S Graham
The CD103(+) subset of lung-migratory dendritic cells (DCs) plays an important role in the generation of CD8(+) T cell responses following respiratory infection. Here, we demonstrate that the dependence on CD103(+) DCs for stimulation of RSV-specific T cells is both epitope and age-dependent. CD103(+) DCs in neonatal mice develop two phenotypically and functionally distinct populations following respiratory infection. Neonatal CD103(+) DCs expressing low levels of CD103 (CD103lo DCs) and other lineage and maturation markers including costimulatory molecules are phenotypically immature and functionally limited...
April 5, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28364278/the-development-and-function-of-dendritic-cell-populations-and-their-regulation-by-mirnas
#4
REVIEW
Haibo Zhou, Li Wu
Dendritic cells (DCs) are important immune cells linking innate and adaptive immune responses. DCs encounter various self and non-self antigens present in the environment and induce different types of antigen specific adaptive immune responses. DCs can be classified into lymphoid tissue-resident DCs, migratory DCs, non-lymphoid resident DCs, and monocyte derived DCs (moDCs). Recent work has also established that DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function...
March 31, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28342908/intestinal-dendritic-cell-licensing-through-toll-like-receptor-4-is-required-for-oral-tolerance-in-patients-with-allergic-contact-dermatitis
#5
Feriel Hacini-Rachinel, Mercedes Gomez de Agüero, Reem Kanjarawi, Ludovic Moro-Sibilot, Jean-Benoit Le Luduec, Claire Macari, Gilles Boschetti, Emilie Bardel, Philippe Langella, Bertrand Dubois, Dominique Kaiserlian
BACKGROUND: Induction of oral tolerance to haptens is an efficient way to prevent allergic contact dermatitis (ACD) in mice. Toll-like receptor (TLR)-mediated sensing of the microbiota contributes to gut homeostasis, yet whether it contributes to induction of oral tolerance has not been documented. OBJECTIVE: We examined whether oral tolerance to the contact sensitizer 2,4-dinitro-fluorobenzene (DNFB) depends on microbiota/TLRs and evaluated the role of TLR4 on the tolerogenic function of intestinal dendritic cells (DCs)...
March 22, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28341057/histone-deacetylase-inhibitors-suppress-immature-dendritic-cell-s-migration-by-regulating-cc-chemokine-receptor-1-expression
#6
Young-Hoon Kim, Jae Kwon Lee
The modulation of immature dendritic cells (iDCs), which involves processes such as phagocytosis, migration, and maturation, is considered a beneficial research theme. Once activated by an antigen, iDCs turn to mature DCs (mDCs) and migrate towards secondary lymphoid organs, and initiate the progress of cellular immunity. Histone deacetylase inhibitors (HDACis) are also thought to be a major modulator of cellular immunity. Herein, we demonstrate that HDACis (trichostatin-A (TSA), sodium butylate (SB), scriptaid (ST)) play a central regulatory role in the migratory activity of iDCs...
February 28, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28329707/dendritic-cells-display-subset-and-tissue-specific-maturation-dynamics-over-human-life
#7
Tomer Granot, Takashi Senda, Dustin J Carpenter, Nobuhide Matsuoka, Joshua Weiner, Claire L Gordon, Michelle Miron, Brahma V Kumar, Adam Griesemer, Siu-Hong Ho, Harvey Lerner, Joseph J C Thome, Thomas Connors, Boris Reizis, Donna L Farber
Maturation and migration to lymph nodes (LNs) constitutes a central paradigm in conventional dendritic cell (cDC) biology but remains poorly defined in humans. Using our organ donor tissue resource, we analyzed cDC subset distribution, maturation, and migration in mucosal tissues (lungs, intestines), associated lymph nodes (LNs), and other lymphoid sites from 78 individuals ranging from less than 1 year to 93 years of age. The distribution of cDC1 (CD141(hi)CD13(hi)) and cDC2 (Sirp-α(+)CD1c(+)) subsets was a function of tissue site and was conserved between donors...
March 21, 2017: Immunity
https://www.readbyqxmd.com/read/28329699/of-human-dc-migrants-and-residents
#8
Elodie Segura, Vassili Soumelis
Migration from peripheral tissues to lymph nodes is a key feature of dendritic cells (DCs), but little is known about the migration patterns of human DCs. By analyzing multiple lymphoid organs and tissues from the same donors, Granot et al. propose that the two main subsets of human DCs display different migratory capacity.
March 21, 2017: Immunity
https://www.readbyqxmd.com/read/28291135/depletion-of-epidermal-langerhans-cells-in-the-skin-lesions-of-pellagra-patients
#9
Sayaka Yamaguchi, Takuya Miyagi, Yoko Sogabe, Masahito Yasuda, Nobuo Kanazawa, Atsushi Utani, Seiichi Izaki, Hiroshi Uezato, Kenzo Takahashi
Pellagra is a nutrient deficiency disease caused by insufficient niacin levels. Recent studies have shown that numbers of epidermal Langerhans cells decreased in other diseases caused by nutritional deficiencies, including necrolytic migratory erythema and acrodermatitis enteropathica. Epidermal Langerhans cells are capable of modulating or even halting the inflammatory reaction. The aim of this study was to examine changes in the number of Langerhans cells and other dendritic cells, and maturation of epidermal Langerhans cells in the lesional and adjacent non-lesional skin in pellagra patients...
February 28, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28276533/immunogenicity-is-preferentially-induced-in-sparse-dendritic-cell-cultures
#10
Aikaterini Nasi, Vishnu Priya Bollampalli, Meng Sun, Yang Chen, Sylvie Amu, Susanne Nylén, Liv Eidsmo, Antonio Gigliotti Rothfuchs, Bence Réthi
We have previously shown that human monocyte-derived dendritic cells (DCs) acquired different characteristics in dense or sparse cell cultures. Sparsity promoted the development of IL-12 producing migratory DCs, whereas dense cultures increased IL-10 production. Here we analysed whether the density-dependent endogenous breaks could modulate DC-based vaccines. Using murine bone marrow-derived DC models we show that sparse cultures were essential to achieve several key functions required for immunogenic DC vaccines, including mobility to draining lymph nodes, recruitment and massive proliferation of antigen-specific CD4+ T cells, in addition to their TH1 polarization...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28256637/ebola-virus-infection-kinetics-in-chimeric-mice-reveal-a-key-role-of-t-cells-as-barriers-for-virus-dissemination
#11
Anja Lüdtke, Paula Ruibal, David M Wozniak, Elisa Pallasch, Stephanie Wurr, Sabrina Bockholt, Sergio Gómez-Medina, Xiangguo Qiu, Gary P Kobinger, Estefanía Rodríguez, Stephan Günther, Susanne Krasemann, Juliana Idoyaga, Lisa Oestereich, César Muñoz-Fontela
Ebola virus (EBOV) causes severe systemic disease in humans and non-human primates characterized by high levels of viremia and virus titers in peripheral organs. The natural portals of virus entry are the mucosal surfaces and the skin where macrophages and dendritic cells (DCs) are primary EBOV targets. Due to the migratory properties of DCs, EBOV infection of these cells has been proposed as a necessary step for virus dissemination via draining lymph nodes and blood. Here we utilize chimeric mice with competent hematopoietic-driven immunity, to show that EBOV primarily infects CD11b(+) DCs in non-lymphoid and lymphoid tissues, but spares the main cross-presenting CD103(+) DC subset...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28245396/-effect-of-thrombocytopenia-on-migration-and-homing-pattern-of-dendritic-cells
#12
Man Zhao, Qian-Qian Zhou, Yu-Long Zhang, Cong Ma, Chu-Lin He, Xiao-Hui Wang, Lin-Sheng Zhan
OBJECTIVE: To investigate the effect of thrombocytopenia on the migration patterns of adoptive dendritic cell(DC) in vivo. METHODS: The mouse model of thrombocytopenia was established by intraperitoneal administration of anti-CD41 mAb MWReg30. Mouse bone marrow(BM)-derived DC were injected into thrombocytopenia mouse by footpad infusion and intravenous infusion. The DC migration and distribution pattern were detected by bioluminescence imaging. RESULTS: More than 80% platelets were cleared in the experimental group which was infused with anti-CD41 antibody...
February 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28228109/fms-like-tyrosine-kinase-3-ligand-increases-resistance-to-burn-wound-infection-through-effects-on-plasmacytoid-dendritic-cells
#13
Leon Bae, Julia K Bohannon, Weihua Cui, Monika Vinish, Tracy Toliver-Kinsky
BACKGROUND: Patients experiencing large thermal injuries are susceptible to opportunistic infections that can delay recovery and lead to sepsis. Dendritic cells (DC) are important for the detection of pathogens and activation of the innate and acquired immune responses. DCs are significantly decreased in burn patients early after injury, and the development of sepsis is associated with persistent DC depletion. In a murine model of burn wound infection, the enhancement of DCs after injury by treatment with the DC growth factor Fms-like tyrosine kinase-3 ligand (FL) enhances neutrophil migration to infection, improves bacterial clearance, and increases survival in a DC-dependent manner...
February 22, 2017: BMC Immunology
https://www.readbyqxmd.com/read/28223923/embryonic-and-postnatal-expression-of-aryl-hydrocarbon-receptor-mrna-in-mouse-brain
#14
Eiki Kimura, Chiharu Tohyama
Aryl hydrocarbon receptor (AhR), a member of the basic helix-loop-helix-Per-Arnt-Sim transcription factor family, plays a critical role in the developing nervous system of invertebrates and vertebrates. Dioxin, a ubiquitous environmental pollutant, avidly binds to this receptor, and maternal exposure to dioxin has been shown to impair higher brain functions and dendritic morphogenesis, possibly via an AhR-dependent mechanism. However, there is little information on AhR expression in the developing mammalian brain...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28182950/pseudogenization-of-the-secreted-effector-gene-ssei-confers-rapid-systemic-dissemination-of-s-typhimurium-st313-within-migratory-dendritic-cells
#15
Sarah E Carden, Gregory T Walker, Jared Honeycutt, Kyler Lugo, Trung Pham, Amanda Jacobson, Donna Bouley, Juliana Idoyaga, Renee M Tsolis, Denise Monack
Genome degradation correlates with host adaptation and systemic disease in Salmonella. Most lineages of the S. enterica subspecies Typhimurium cause gastroenteritis in humans; however, the recently emerged ST313 lineage II pathovar commonly causes systemic bacteremia in sub-Saharan Africa. ST313 lineage II displays genome degradation compared to gastroenteritis-associated lineages; yet, the mechanisms and causal genetic differences mediating these infection phenotypes are largely unknown. We find that the ST313 isolate D23580 hyperdisseminates from the gut to systemic sites, such as the mesenteric lymph nodes (MLNs), via CD11b(+) migratory dendritic cells (DCs)...
February 8, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28179507/intestinal-commensal-bacteria-mediate-lung-mucosal-immunity-and-promote-resistance-of-newborn-mice-to-infection
#16
Jerilyn Gray, Katherine Oehrle, George Worthen, Theresa Alenghat, Jeffrey Whitsett, Hitesh Deshmukh
Immature mucosal defenses contribute to increased susceptibility of newborn infants to pathogens. Sparse knowledge of age-dependent changes in mucosal immunity has hampered improvements in neonatal morbidity because of infections. We report that exposure of neonatal mice to commensal bacteria immediately after birth is required for a robust host defense against bacterial pneumonia, the leading cause of death in newborn infants. This crucial window was characterized by an abrupt influx of interleukin-22 (IL-22)-producing group 3 innate lymphoid cells (IL-22(+)ILC3) into the lungs of newborn mice...
February 8, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28087664/human-blood-cd1c-dendritic-cells-encompass-cd5high-and-cd5low-subsets-that-differ-significantly-in-phenotype-gene-expression-and-functions
#17
Xiangyun Yin, Haisheng Yu, Xiaoyang Jin, Jingyun Li, Hao Guo, Quanxing Shi, Zhao Yin, Yong Xu, Xuefei Wang, Rong Liu, Shouli Wang, Liguo Zhang
There are three major dendritic cell (DC) subsets in both humans and mice, that is, plasmacytoid DCs and two types of conventional DCs (cDCs), cDC1s and cDC2s. cDC2s are important for polarizing CD4(+) naive T cells into different subsets, including Th1, Th2, Th17, Th22, and regulatory T cells. In mice, cDC2s can be further divided into phenotypically and functionally distinct subgroups. However, subsets of human cDC2s have not been reported. In the present study, we showed that human blood CD1c(+) cDCs (cDC2s) can be further separated into two subpopulations according to their CD5 expression status...
January 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28081153/dermal-%C3%AE-%C3%AE-t-cells-do-not-freely-re-circulate-out-of-skin-and-produce-il-17-to-promote-neutrophil-infiltration-during-primary-contact-hypersensitivity
#18
Xiaodong Jiang, Chang Ook Park, Jenna Geddes Sweeney, Min Jae Yoo, Olivier Gaide, Thomas Seth Kupper
The role of mouse dermal γδ T cells in inflammatory skin disorders and host defense has been studied extensively. It is known that dendritic epidermal T cells (DETC) have a monomorphic γδ T cell receptor (TCR) and reside in murine epidermis from birth. We asked if dermal γδ cells freely re-circulated out of skin, or behaved more like dermal resident memory T cells (TRM) in mice. We found that, unlike epidermal γδ T cells (DETC), dermal γδ cells are not homogeneous with regard to TCR, express the tissue resident T cell markers CD69 and CD103, bear skin homing receptors, and produce IL-17 and IL-22...
2017: PloS One
https://www.readbyqxmd.com/read/28063036/visualization-of-the-t-cell-response-in-contact-hypersensitivity
#19
Gyohei Egawa, Kenji Kabashima
Contact hypersensitivity (CHS) is the most basic murine model for type IV hypersensitivity. This dermatitis model is mediated by hapten-sensitized, skin-infiltrating T cells. Recent intravital imaging studies have demonstrated the dynamic migratory property of skin-infiltrating T cells and the orchestrated interaction of T cells with dermal dendritic cells. Multiphoton microscopy enables the direct, three-dimensional, and minimally invasive imaging of in vivo skin samples with high spatiotemporal resolution...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28024184/serpinb9-is-a-marker-of-antigen-cross-presenting-dendritic-cells
#20
M S Mangan, J Vega-Ramos, L T Joeckel, A J Mitchell, A Rizzitelli, B Roediger, D Kaiserman, W W Weninger, J A Villadangos, P I Bird
Serpinb9 (Sb9, also called Spi6) is an intracellular inhibitor of granzyme B (grB) that protects cytotoxic lymphocytes from grB-mediated death. In addition, Sb9 is also expressed in accessory immune cells, including dendritic cells (DCs), although its role is debated. Recently, we have demonstrated that Sb9 plays a grB-independent role in cross-presentation of antigens by CD8(+) DCs. Here, using a mouse line expressing green fluorescent protein knocked in under the control of the Sb9 promoter, we demonstrate that Sb9 expression is highest in those tissue-resident and migratory DC subsets capable of cross-presentation...
December 23, 2016: Molecular Immunology
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