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https://www.readbyqxmd.com/read/28637341/assessment-of-workers-exposure-to-grain-dust-and-bioaerosols-during-the-loading-of-vessels-hold-an-example-at-a-port-in-the-province-of-qu%C3%A3-bec
#1
Geneviève Marchand, Marie Gardette, Kiet Nguyen, Valérie Amano, Eve Neesham-Grenon, Maximilien Debia
Longshoremen are exposed to large amounts of grain dust while loading of grain into the holds of vessels. Grain dust inhalation has been linked to respiratory diseases such as chronic bronchitis, hypersensitivity, pneumonitis, and toxic pneumonitis. Our objective was to characterize the exposure of longshoremen to inhalable and total dust, endotoxins, and cultivable bacteria and fungi during the loading of grain in a vessel's hold at the Port of Montreal in order to assess the potential health risks. Sampling campaigns were conducted during the loading of two different types of grain (wheat and corn)...
June 15, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28635648/deoxyelephantopin-and-isodeoxyelephantopin-as-potential-anticancer-agents-with-effects-on-multiple-signaling-pathways
#2
REVIEW
Tahir Mehmood, Amara Maryam, Hamed A Ghramh, Muhammad Khan, Tonghui Ma
Cancer is the 2nd leading cause of death worldwide. The development of drugs to target only one specific signaling pathway has limited therapeutic success. Developing chemotherapeutics to target multiple signaling pathways has emerged as a new prototype for cancer treatment. Deoxyelephantopin (DET) and isodeoxyelephantopin (IDET) are sesquiterpene lactone components of "Elephantopus scaber and Elephantopus carolinianus", traditional Chinese medicinal herbs that have long been used as folk medicines to treat liver diseases, diabetes, diuresis, bronchitis, fever, diarrhea, dysentery, cancer, and inflammation...
June 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28633386/oral-administration-of-tea-saponins-to-relive-oxidative-stress-and-immune-suppression-in-chickens
#3
X Chi, S Bi, W Xu, Y Zhang, S Liang, S Hu
The present study was designed to evaluate the effects of tea saponins on oxidative stress induced by cyclophosphamide in chickens. One hundred twenty chickens were randomly divided into 5 groups. Groups 3 to 4 received intramuscular injection of cyclophosphamide to induce oxidative stress and immunosuppression. After that, groups 2 and 4 were orally administered tea saponins in drinking water for 7 d. Then, groups 1 to 4 were immunized with a live, bivalent vaccine of Newcastle disease virus and infectious bronchitis virus...
June 15, 2017: Poultry Science
https://www.readbyqxmd.com/read/28632331/the-validity-of-register-data-to-identify-children-with-atopic-dermatitis-asthma-or-allergic-rhinoconjunctivitis
#4
Lone Graff Stensballe, Lotte Klansø, Andreas Jensen, Ann Haerskjold, Simon Francis Thomsen, Jacob Simonsen
BACKGROUND: The incidence of atopic dermatitis, wheezing, asthma and allergic rhinoconjunctivitis have been increasing. Register-based studies are essential for research in subpopulations with specific diseases, and facilitate epidemiological studies to identify causes and evaluate interventions. Algorithms have been developed to identify children with atopic dermatitis, asthma or allergic rhinoconjunctivitis using register information on disease-specific dispensed prescribed medication and hospital contacts, but the validity of the algorithms has not been evaluated...
June 20, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28631126/a-comparative-study-of-hospital-admissions-for-respiratory-diseases-during-normal-and-dusty-days-in-iran
#5
Sahar Geravandi, Pierre Sicard, Yusef Omidi Khaniabadi, Alessandra De Marco, Ali Ghomeishi, Gholamreza Goudarzi, Mohammad Mahboubi, Ahmad Reza Yari, Sina Dobaradaran, Ghasem Hassani, Mohammad Javad Mohammadi, Shahram Sadeghi
During the last century, most of people around the world moved from communicable to non-communicable diseases, mainly due to air pollution. Air pollutants and dust storm increase risk of morbidity, for cardiovascular and respiratory diseases, and increase the number of deaths. The city of Ahvaz is considered as the focal point of air pollution and dust storm in Iran. The aim of this study was to determine the number of Hospital Admission Respiratory Disease (HARD) including asthma attacks, acute bronchitis and chronic obstructive pulmonary disease attributed to PM10 by a descriptive study during normal and dust event days in Ahvaz during the time period 2010-2012...
June 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28626902/haemophilus-influenzae-oral-vaccination-for-preventing-acute-exacerbations-of-chronic-bronchitis-and-chronic-obstructive-pulmonary-disease
#6
REVIEW
Edward Teo, Kathleen Lockhart, Sai Navya Purchuri, Jennifer Pushparajah, Allan W Cripps, Mieke L van Driel
BACKGROUND: Chronic bronchitis and chronic obstructive pulmonary disease (COPD) are serious conditions in which patients are predisposed to viral and bacterial infections resulting in potentially fatal acute exacerbations. Chronic obstructive pulmonary disease is defined as a lung disease characterised by obstruction to lung airflow that interferes with normal breathing. Antibiotic therapy has not been particularly useful in eradicating bacteria such as non-typeable Haemophilus influenzae (NTHi) because they are naturally occurring flora of the upper respiratory tract in many people...
June 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28626858/antibiotics-for-acute-bronchitis
#7
REVIEW
Susan M Smith, Tom Fahey, John Smucny, Lorne A Becker
BACKGROUND: The benefits and risks of antibiotics for acute bronchitis remain unclear despite it being one of the most common illnesses seen in primary care. OBJECTIVES: To assess the effects of antibiotics in improving outcomes and to assess adverse effects of antibiotic therapy for people with a clinical diagnosis of acute bronchitis. SEARCH METHODS: We searched CENTRAL 2016, Issue 11 (accessed 13 January 2017), MEDLINE (1966 to January week 1, 2017), Embase (1974 to 13 January 2017), and LILACS (1982 to 13 January 2017)...
June 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28624716/seizure-related-hospital-admissions-readmissions-and-costs-comparisons-with-asthma-and-diabetes-in-south-australia
#8
Michelle L Bellon, Christopher Barton, Nikki McCaffrey, Denise Parker, Claire Hutchinson
PURPOSE: Seizures are listed as an Ambulatory Care Sensitive Condition (ACSC), where, in some cases, hospitalisation may be avoided with appropriate preventative and early management in primary care. We examined the frequencies, trends and financial costs of first and subsequent seizure-related hospital admissions in the adult and paediatric populations, with comparisons to bronchitis/asthma and diabetes admissions in South Australia between 2012 and 2014. METHODS: De-identified hospital separation data from five major public hospitals in metropolitan South Australia were analysed to determine the number of children and adults admitted for the following Australian Refined Diagnosis Related Groups: seizure related conditions; bronchitis/asthma; and diabetes...
June 10, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28620439/living-well-with-copd
#9
(no author information available yet)
COPD is a group of conditions that includes chronic bronchitis and emphysema.
June 2017: Breathe
https://www.readbyqxmd.com/read/28619140/decreased-egg-production-in-laying-hens-associated-with-infection-with-genotype-3-avian-hepatitis-e-virus-strain-from-china
#10
Qin Zhao, Baoyuan Liu, Yani Sun, Taofeng Du, Yiyang Chen, Xinjie Wang, Huixia Li, Yuchen Nan, Gaiping Zhang, En-Min Zhou
To determine the relationship between decreased egg production and avian HEV infection, thirty healthy 23-week-old Hy-Line Variety Brown layer hens were randomly divided into 3 groups with 10 hens per group. Next, a genotype 3 avian HEV strain from China was used to inoculate laying hens via oronasal or intravenous routes using a 50% chicken infectious dose of 500. All hens were necropsied at 14 weeks postinoculation (wpi). Fecal virus shedding, viremia, seroconversion, serum alanine aminotransferase (ALT) increases and liver lesions showed that after intravenous (i...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28619139/analysis-of-antigenicity-and-pathogenicity-reveals-major-differences-among-qx-like-infectious-bronchitis-viruses-and-other-serotypes
#11
Shihong Yan, Xiaoyu Liu, Jing Zhao, Gang Xu, Ye Zhao, Guozhong Zhang
Avian coronavirus infectious bronchitis virus (IBV) causes considerable damage to the poultry industry worldwide and the proportion of QX-like genotype isolates have increased over time. Here, to better understand the antigenicity and pathogenicity of this genotype, we conducted sequence analyses, cross neutralization tests, and also examined the pathogenicity of two strains, SD and SZ. Sequence analyses revealed that SD and SZ isolates belong to the QX-like IBV genotype and share high homology in their full-length genomes...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28619134/genetic-antigenic-and-pathogenic-characteristics-of-avian-infectious-bronchitis-viruses-genotypically-related-to-793-b-in-china
#12
Zongxi Han, Wenjun Zhao, Yuqiu Chen, Qianqian Xu, Junfeng Sun, Tingting Zhang, Yan Zhao, Shuling Liang, Mengying Gao, Qiuling Wang, Xiangang Kong, Shengwang Liu
In this study, 20 infectious bronchitis virus (IBV) strains, which were genotypically related to 793/B, as assessed by an S1 gene comparison and a complete genomic sequence analysis, were isolated and identified from 2009 to 2014 in China. Phylogenetic analysis, network tree, similarity plot analysis, Recombination Detection Program 4(RDP4) and sequence comparison revealed that 12 of the 20 isolates were likely the reisolated vaccine virus. One isolate, ck/CH/LSD/110857, was shown to have originated from recombination events between H120- and 4/91-like vaccine strains that did not result in changes of antigenicity and pathogenicity...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28619132/co-infection-of-h9n2-subtype-avian-influenza-virus-and-infectious-bronchitis-virus-decreases-sp-a-expression-level-in-chickens
#13
Qi Huang, Kai Wang, Ling Pan, Kezong Qi, Hongmei Liu, Hongjun Chen
Chicken surfactant protein A (cSP-A) is a collectin believed to play an important role in antiviral immunity. However, cSP-A expression in the respiratory tract of chickens after viral co-infection remains unclear. The aim of this study was the detection and characterization of cSP-A in co-infected chickens. For this purpose, four-week-old specific pathogen-free (SPF) chickens were divided into five groups and inoculated intranasally with H9N2 subtype avian influenza virus (AIV), infectious bronchitis virus (IBV), or Newcastle disease virus (NDV)...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28614052/safety-of-the-neprilysin-renin-angiotensin-system-inhibitor-lcz696
#14
REVIEW
Bo Li, Yunhe Zhao, Bo Yin, Mengfei Helian, Xinmei Wang, Feng Chen, Hongxia Zhang, Hui Sun, Bin Meng, Fengshuang An
OBJECTIVES: The combined neprilysin/rennin-angiotensin system inhibitor sacubitril/valsartan (LCZ696) has shown its superiority over ACEI/ARB therapy. In view of the existing concern of its adverse effects, we aimed to provide evidence of the safety of the new drug. RESULTS: A total of 6 randomized trials with 11,821 subjects were included in this analysis. No significant differences were found in any adverse effects between LCZ696 and ACEI/ARB or placebo groups...
May 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28606324/serological-lessons-from-the-bovine-lungworm-dictyocaulus-viviparus-antibody-titre-development-is-independent-of-the-infection-dose-and-reinfection-shortens-seropositivity
#15
Christina Strube, Andrea Springer, Anne-Marie Schunn, Andrew B Forbes
Infections with the bovine lungworm Dictyocaulus viviparus, the causative agent of parasitic bronchitis, are accompanied by substantial economic losses due to impacts on production, clinical respiratory disease or even death of diseased cattle. To detect lungworm antibodies in cattle, an enzyme-linked immunosorbent assay (ELISA) based on recombinant major sperm protein (MSP) has been developed. However, it remained unknown whether the infection dose influences antibody levels, and how acquired immunity influences antibody level patterns during reinfections...
August 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28606144/a-reverse-genetics-system-for-avian-coronavirus-infectious-bronchitis-virus-based-on-targeted-rna-recombination
#16
Steven J van Beurden, Alinda J Berends, Annika Krämer-Kühl, Dieuwertje Spekreijse, Gilles Chénard, Hans-Christian Philipp, Egbert Mundt, Peter J M Rottier, M Hélène Verheije
BACKGROUND: Avian coronavirus infectious bronchitis virus (IBV) is a respiratory pathogen of chickens that causes severe economic losses in the poultry industry worldwide. Major advances in the study of the molecular biology of IBV have resulted from the development of reverse genetics systems for the highly attenuated, cell culture-adapted, IBV strain Beaudette. However, most IBV strains, amongst them virulent field isolates, can only be propagated in embryonated chicken eggs, and not in continuous cell lines...
June 12, 2017: Virology Journal
https://www.readbyqxmd.com/read/28605262/chronic-obstructive-pulmonary-disease-from-injury-to-genomic-stability
#17
Luiz Philippe da Silva Sergio, Flavia de Paoli, Andre Luiz Mencalha, Adenilson de Souza da Fonseca
Chronic obstructive pulmonary disease (COPD) is the fourth cause of death in the world and it is currently presenting a major global public health challenge, causing premature death from pathophysiological complications and rising economic and social burdens. COPD develops from a combination of factors following exposure to pollutants and cigarette smoke, presenting a combination of both emphysema and chronic obstructive bronchitis, which causes lung airflow limitations that are not fully reversible by bronchodilators...
June 12, 2017: COPD
https://www.readbyqxmd.com/read/28603519/antigen-sparing-and-enhanced-efficacy-of-multivalent-vaccines-adjuvanted-with-immunopotentiators-in-chickens
#18
Peipei Wu, Jihu Lu, Lei Feng, Hongzhuan Wu, Xuehua Zhang, Mei Mei, Jibo Hou, Xiufan Liu, Yinghua Tang
We previously described that immunopotentiators, CVCVA5, increased the efficacy of H5 and H9 subtype avian influenza vaccines in chickens, ducks, and geese. In this study, we further investigated the effects of the CVCVA5 for improving the efficacy of other univalent or multivalent inactivated vaccines. The immune response administrated with half-dose of monovalent vaccine plus CVCVA5 were higher than those of one dose of monovalent vaccine without immunopotentiators as measured by levels of antibodies from serum, tears and bronchoalveolar lavage fluids, and cytokines of IFNγ and IL-4 from serum...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28598050/consensus-document-on-home-nebulization-for-maintenance-treatment-of-obstructive-airway-diseases-a-joint-initiative-by-the-national-allergy-asthma-bronchitis-institute-naabi-and-chest-research-foundation-crf
#19
Aloke G Ghoshal, Sundeep Salvi, Raja Dhar, Randeep Guleria, Ashok Mahashur, Anshuman Mukhopadhyay, Rmpl Ramanathan
Recent years have seen an increase in the use of nebulizers for delivering maintenance therapy in obstructive airway diseases (OADs) such as asthma and chronic obstructive pulmonary disease (COPD). The probable factors associated with this increase at home are: convenience of drug delivery, technological advances making the nebulizer equipment more efficient and portable, increase in the prevalence of OADs and the ageing population which may impact the optimal use of handheld inhalers such as pressurized metered dose inhalers (pMDIs) and dry powder inhalers (DPIs)...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28592581/the-stop-ab-trial-protocol-efficacy-and-safety-of-discontinuing-patient-antibiotic-treatment-when-physicians-no-longer-consider-it-necessary
#20
Carl Llor, Ana Moragas, Carolina Bayona, Josep M Cots, José M Molero, Joana Ribas, Julio Francisco Fóthy, Isabel Gutiérrez, Coro Sánchez, Jesús Ortega, Javier Arranz, Jenifer Botanes, Purificación Robles
INTRODUCTION: Since 2011, the Spanish Society of Family Medicine has recommended general practitioners (GPs) to ask their patients to stop taking antibiotics when they suspect a viral infection. However, this practice is seldom used because uncertainty about diagnosis, and fear of consequences of discontinuing antibiotic therapy, as well as perceived pressure to continue prescribing antibiotics and potential conflict with patients are more of a concern for GPs than antibiotic resistance...
June 6, 2017: BMJ Open
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