keyword
MENU ▼
Read by QxMD icon Read
search

anticancer drug research

keyword
https://www.readbyqxmd.com/read/28804913/on-bh3-mimetics-and-ca-2-signaling
#1
Pawel E Ferdek, Monika A Jakubowska
Preclinical Research BH3 mimetics are anticancer agents that reproduce the spatial arrangement of the BH3 domain of Bcl-2 family proteins. Just like the BH3-only proteins, these compounds bind to the hydrophobic cleft of the pro-survival Bcl-2 members such as Bcl-2 or Bcl-xL, and disrupt their heterodimerization with pro-apoptotic Bax or Bak, sensitizing cells to chemotherapy. In recent years, it has become clear that Bcl-2 family proteins are engaged in regulation of intracellular Ca(2+) homeostasis, including Ca(2+) release from the intracellular stores as well as Ca(2+) fluxes across the plasma membrane...
August 13, 2017: Drug Development Research
https://www.readbyqxmd.com/read/28803677/indole-fused-azepines-and-analogues-as-anticancer-lead-molecules-privileged-findings-and-future-directions
#2
REVIEW
Ashok K Singh, Vinit Raj, Sudipta Saha
The search for new lead compounds of simple structure, displaying highest quality anti-tumor potency with new mechanisms of action and least adverse effects is the major intention of cancer drug discovery now a days. For the time being, indole-fused azepines emerged as a simple class of compounds prolifically designed with strong pharmacological significances in particular of cancer protecting ability. In the recent years from the efforts of our research group, indole-fused heteroazepines, a simple structural class achieved by fusion of indole with oxygen, sulphur and nitrogen containing heteroazepine rings, have known for its superior outcomes in cancer treatment...
August 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28802167/induction-of-senescence-in-cancer-cells-by-5-aza-2-deoxycytidine-bioinformatics-and-experimental-insights-to-its-targets
#3
Jayarani F Putri, Nashi Widodo, Kazuichi Sakamoto, Sunil C Kaul, Renu Wadhwa
5'-Aza-2'-deoxycytidine (5-Aza-dC) is a demethylating drug that causes genome-wide hypomethylation resulting in the expression of several tumor suppressor genes causing growth arrest of cancer cells. Cancer is well established as a multifactorial disease and requires multi-module therapeutics. Search for new drugs and their approval by FDA takes a long time. Keeping this in view, research on new functions of FDA-approved anticancer drugs is desired to expand the list of multi-module functioning drugs for cancer therapy...
August 2, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28800308/cancer-stem-cells-as-functional-biomarkers
#4
Vito D'Andrea, Alessandra Panarese, Maya Tonda, Marco Biffoni, Massimo Monti
According to the American Association of Cancer Research (AACR), a Cancer Stem Cell is a cell within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that constitutes the tumor [1]. Cancer Stem Cells (CSCs) are involved in the metastatic process, in the resistance to therapeutic treatments of many types of human cancers and consequently in the onset of recurrences. Numerous translational studies have been conducted to understand CSC characteristics and evaluate association between CSC-related biomarkers and clinical outcomes...
July 31, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28795851/selective-induction-of-apoptosis-in-mcf7-cancer-cell-by-targeted-liposomes-functionalized-with-mannose-6-phosphate
#5
Cristina Minnelli, Laura Cianfruglia, Emiliano Laudadio, Roberta Galeazzi, Michela Pisani, Emanuela Crucianelli, Davide Bizzaro, Tatiana Armeni, Giovanna Mobbili
Liposomes are versatile platforms to carry anticancer drugs in targeted drug delivery; they can be surface modified by different strategies and, when coupled with targeting ligands, are able to increase cellular internalization and organelle-specific drug delivery. An interesting strategy of antitumoral therapy could involve the use of lysosomotropic ligand-targeted liposomes loaded with molecules, which can induce lysosomal membrane permeabilization (LMP), leakage of cathepsins into the cytoplasm and subsequent apoptosis...
August 10, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28782482/drug-combination-in-clinical-cancer-treatments
#6
Da-Yong Lu, Ting-Ren Lu, Nagendra Sastry Yarla, Hong-Ying Wu, Bin Xu, Jian Ding, Hong Zhu
AIM: The modality of anticancer drug combinations needs to be renovated from empirical into technical-supportive systems. METHODS: To challenge past therapeutic routines, the new landscape may be established. Among the different areas of anticancer drug combination study, research in the fields of medical study is the most important one-including disciplinary of therapeutics in different cancer stages, modern genetic/molecular diagnostics, cancer bioinformatics, traditional Chinese medicine, mathematical data analysis, therapeutic toxicity monitor, personalized cancer medicine and so on...
August 3, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28782352/cornus-mas-a-review-on-traditional-uses-and-pharmacological-properties
#7
Fatemeh Hosseinpour-Jaghdani, Tahoora Shomali, Sajedeh Gholipour-Shahraki, Mohammad Rahimi-Madiseh, Mahmoud Rafieian-Kopaei
Medicinal plants that are used today have been known by people of ancient cultures around the world and have largely been considered due to their medicinal properties. Cornus mas L. (Cornelian cherry) is one of these medicinal plants with high level of antioxidant activity. Cornelian cherry is an attractive ornamental plant with delicious fruit having nutritional and therapeutic values. The main purpose of this paper is to present and summarize the pharmacological and therapeutic effects from researches done on Cornelian cherry in studies from 2000 to 2016...
March 31, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28781808/treatment-of-metastatic-refractory-colorectal-cancer-following-regorafenib-failure
#8
Nobumichi Takeuchi, Kumiko Koike, Sonomi Yoshida, Akiko Kudo, Nodoka Sekiguchi, Ataru Nakayama, Kouji Kubota, Takashi Rokuhara, Masayuki Kitahara
At present, there is no set strategy for the treatment of patients with colorectal cancer subsequent to the failure of standard treatment, other than the use of regorafenib (RGR) and TAS-102. The best order in which to use these drugs, and their safety and efficacy in combination with other drugs, are currently under investigation. It has been reported that RGR has a resensitizing effect on tumors that have previously failed to respond to anticancer drugs; this makes it a promising salvage therapy for colorectal cancer...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28771722/co-administration-of-a-tumor-penetrating-peptide-improves-the-therapeutic-efficacy-of-paclitaxel-in-a-novel-air-grown-lung-cancer-3d-spheroid-model
#9
Sweta K Gupta, Elisa A Torrico Guzmán, Samantha A Meenach
Three-dimensional (3D) cell culture platforms are increasingly being used in cancer research and drug development since they mimic avascular tumors in vitro. In the present study, we focused on the development of a novel air-grown multicellular spheroid (MCS) model to mimic in vivo tumors for understanding lung cancer biology and improvement in the evaluation of aerosol anticancer therapeutics. 3D MCS were formed using A549 lung adenocarcinoma cells, comprising cellular heterogeneity with respect to different proliferative and metabolic gradients...
August 2, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28768489/improved-anticancer-drug-response-prediction-in-cell-lines-using-matrix-factorization-with-similarity-regularization
#10
Lin Wang, Xiaozhong Li, Louxin Zhang, Qiang Gao
BACKGROUND: Human cancer cell lines are used in research to study the biology of cancer and to test cancer treatments. Recently there are already some large panels of several hundred human cancer cell lines which are characterized with genomic and pharmacological data. The ability to predict drug responses using these pharmacogenomics data can facilitate the development of precision cancer medicines. Although several methods have been developed to address the drug response prediction, there are many challenges in obtaining accurate prediction...
August 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28767041/multifunctional-halloysite-nanotubes-for-targeted-delivery-and-controlled-release-of-doxorubicin-i-in-vitro-i-and-i-in-vivo-i-studies
#11
Yuwei Hu, Jian Chen, Xiufang Li, Yanhua Sun, Shen Huang, Yuqing Li, Hui Liu, Jiangfeng Xu, Shian Zhong
The current state of cancer therapy encourages researchers to develop novel efficient nanocarriers. Halloysite nanotubes (HNTs) are good nanocarrier candidates due to their unique nanoscale (40-80 nm in diamter and 200-1500 nm in length) and hollow lumen, as well as good biocompatibility and low cost. In our study, we prepared a type of folate-mediated targeting and redox-triggered anticancer drug delivery system, so that Doxorubicin (DOX) can be specifically transported to tumor sites due to the over-expressed folate-receptors on the surface of cancer cells...
August 2, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28763458/synthesis-of-novel-coumarin-nucleus-based-dpa-drug-like-molecular-entity-in-vitro-dna-cu-ii-binding-dna-cleavage-and-pro-oxidant-mechanism-for-anticancer-action
#12
Saman Khan, Ali Mohammed Malla, Atif Zafar, Imrana Naseem
Despite substantial research on cancer therapeutics, systemic toxicity and drug-resistance limits the clinical application of many drugs like cisplatin. Therefore, new chemotherapeutic strategies against different malignancies are needed. Targeted cancer therapy is a new paradigm for cancer therapeutics which targets pathways or chemical entities specific to cancer cells than normal ones. Unlike normal cells, cancer cells contain elevated copper which plays an integral role in angiogenesis. Copper is an important metal ion associated with chromatin DNA, particularly with guanine...
2017: PloS One
https://www.readbyqxmd.com/read/28762580/mnal-layered-double-hydroxide-nanoparticles-as-a-dual-functional-platform-for-magnetic-resonance-imaging-and-sirna-delivery
#13
Huali Zuo, Weiyu Chen, Bei Li, Kewei Xu, Helen Cooper, Zi Gu, Zhi Ping Xu
Multifunctional nanoparticles for cancer theranosis have been widely explored for effective cancer detection and therapy. In this research, dually functionalised manganese-based layered double hydroxide nanoparticles (Mn-LDHs) have been examined as an effective anticancer drug/gene delivery system and T1-weighted magnetic resonance imaging (MRI) modality for brain cancer theranostics. Such Mn-LDHs have been shown to accommodate dsDNA/siRNAs and efficiently deliver to Neuro-2a cells (N2a). Mn-LDHs have also shown high biocompatibility with low cytotoxicity...
August 1, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28761744/discussing-and-prescribing-expensive-unfunded-anticancer-drugs-in-australia
#14
Deme John Karikios, Linda Mileshkin, Andrew Martin, Danielle Ferraro, Martin R Stockler
OBJECTIVE: Australia has a publicly funded universal healthcare system which heavily subsidises the cost of most registered anticancer drugs. The use of anticancer drugs that are unfunded, that is, not subsidised by the government, entails substantial out-of-pocket costs for patients. We sought to determine how frequently Australian medical oncologists discuss and prescribe unfunded anticancer drugs, and their attitudes and beliefs about their use. METHODS: Members of the Medical Oncology Group of Australia (MOGA) completed an online survey about their clinical practices over a recent 3-month period...
2017: ESMO Open
https://www.readbyqxmd.com/read/28760313/recent-advances-2015-2016-in-anticancer-hybrids
#15
REVIEW
Nagaraju Kerru, Parvesh Singh, Neil Koorbanally, Raghu Raj, Vipan Kumar
In spite of the development of a large number of novel anticancer drugs over the years, Cancer remains as a prominent cause of death, worldwide. Numerous drugs that are currently in clinical practice have developed multidrug resistance along with fatal side effects. Therefore, the utilization of single-target therapy is incapable of providing an effective control on the malignant process. Molecular hybridization, involving a combination of two or more pharmacophores of bioactive scaffolds to generate a single molecular architecture with improved affinity and activity, in comparison to their parent molecules, has emerged as a promising strategy in recent drug discovery research...
July 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28754470/oleanane-ursane-and-quinone-methide-friedelane-type-triterpenoid-derivatives-recent-advances-in-cancer-treatment
#16
REVIEW
Jorge A R Salvador, Ana S Leal, Ana S Valdeira, Bruno M F Gonçalves, Daniela P S Alho, Sandra A C Figueiredo, Samuel M Silvestre, Vanessa I S Mendes
Natural pentacyclic triterpenoids (PTs) have been often reported to exhibit a wide range of biological activities. Among them, the anticancer and anti-inflammatory activities are the most studied. Over the last two decades, the number of publications reporting the anticancer effects of PTs has risen exponentially, reflecting the increasing interest in these natural products for the development of new antineoplastic drugs. Among of the most investigated PTs regarding their anticancer properties are oleanane-, ursane and friedelane-types, including oleanolic, glycyrrhetinic, ursolic and asiatic acids, and celastrol, among others...
July 14, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28753268/microscale-mass-spectrometry-analysis-of-extracellular-metabolites-in-live-multicellular-tumor-spheroids
#17
Mei Sun, Xiang Tian, Zhibo Yang
Extracellular compounds in tumors play critical roles in intercellular communication, tumor proliferation, and cancer cell metastasis. However, the lack of appropriate techniques leads to limited studies of extracellular metabolite. Here, we introduced a microscale collection device, the Micro-funnel, fabricated from biocompatible fused silica capillary. With a small probe size (∼25 μm), the Micro-funnel can be implanted into live multicellular tumor spheroids to accumulate the extracellular metabolites produced by cancer cells...
August 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28743635/molecular-imaging-in-drug-development-update-and-challenges-for-radiolabeled-antibodies-and-nanotechnology
#18
REVIEW
Ilaria Colombo, Marta Overchuk, Juan Chen, Raymond M Reilly, Gang Zheng, Stephanie Lheureux
Despite the significant advancement achieved in understanding the molecular mechanisms responsible for cancer transformation and aberrant proliferation, leading to novel targeted cancer therapies, significant effort is still needed to "personalize" cancer treatment. Molecular imaging is an emerging field that has shown the ability to characterize in vivo the molecular pathways present at the cancer cell level, enabling diagnosis and personalized treatment of malignancies. These technologies, particularly SPECT and PET also permit the development of novel radiotheranostic probes, which provide capabilities for diagnosis and treatment with the same agent...
July 22, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28734001/control-of-reversible-activation-dynamics-of-ru-%C3%AE-%C3%A2-%C3%AE%C2%BA%C3%A2-c%C3%A2-h%C3%A2-c%C3%A2-h%C3%A2-nh%C3%A2-xy-n-and-the-effect-of-chelate-ligand-variation
#19
Francisco Martínez-Peña, Ana M Pizarro
The potential use of organometallic ruthenium complexes as anticancer drugs is well known. Here we show a family of activatable tethered ruthenium(II) arene complexes of general formula [Ru(η⁶:κ¹-C₆H₅(C₆H₄)NH₂)(XY)]n+ (closed tether-ring) bearing different chelating XY ligands (XY = aliphatic diamine, phenylenediamine, oxalato, bis(phosphino)ethane). The activation of these complexes (closed-to-open tether conversion) occurs in methanol and dimethylsulfoxide at different rates, and to different reaction extents at equilibrium...
July 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28732807/pharmacology-and-toxicology-of-%C3%AE-and-%C3%AE-asarone-a-review-of-preclinical-evidence
#20
REVIEW
Ranjithkumar Chellian, Vijayapandi Pandy, Zahurin Mohamed
BACKGROUND: Asarone is one of the most researched phytochemicals and is mainly present in the Acorus species and Guatteria gaumeri Greenman. In preclinical studies, both α- and β-asarone have been reported to have numerous pharmacological activities and at the same time, many studies have also revealed the toxicity of α- and β-asarone. PURPOSE: The purpose of this comprehensive review is to compile and analyze the information related to the pharmacokinetic, pharmacological, and toxicological studies reported on α- and β-asarone using preclinical in vitro and in vivo models...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
keyword
keyword
76359
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"