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https://www.readbyqxmd.com/read/29334179/functionalized-nanoparticles-efficiently-enhancing-the-targeted-delivery-tumor-penetration-and-anticancer-activity-of-7-ethyl-10-hydroxycamptothecin
#1
Xun Liu, Jingxing Si, Qianzhi Zhang, Qian Huang, Danxia Gu, Hao Yang, Xu Chen, Youqing Shen, Meihua Sui
The enhanced permeability and retention (EPR) effect of tumors is much more complex than initially defined, and it alone is not sufficient for targeted delivery of nanosized agents. Meanwhile, poor tumor penetration is another major challenge for the treatment of solid tumors using nanoparticles. Development of delivery systems for SN38, the active metabolite of CPT-11 in human and a very potent anticancer molecule, has become an attractive research area. PEGx -p(HEMASN38)y (x and y are viable), a prodrug synthesized by using polyethylene glycol (PEG) as initiator and SN38 as monomer through atom transfer radical polymeration (ATRP) method, is previously reported...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29333657/gelatin-methacryloyl-hydrogels-in-the-absence-of-a-crosslinker-as-3d-glioblastoma-multiforme-gbm-mimetic-microenvironment
#2
Pelin Erkoc, Fidan Seker, Tugba Bagci-Onder, Seda Kizilel
3D platforms are important for monitoring tumor progression and screening drug candidates to eradicate tumors such as glioblastoma multiforme (GBM), a malignant type of human brain tumor. Here, a new strategy is reported that exploits visible-light-induced crosslinking of gelatin where the reaction is carried out in the absence of an additional crosslinker. Visible light-induced crosslinking promotes the design of cancer microenvironment-mimetic system without compromising the cell viability during the process and absence of crosslinker facilitates the synthesis of the unique construct...
January 15, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29333084/effects-of-%C3%AE-mangostin-on-viability-growth-and-cohesion-of-multicellular-spheroids-derived-from-human-breast-cancer-cell-lines
#3
Giuseppe Scolamiero, Claudia Pazzini, Francesca Bonafè, Carlo Guarnieri, Claudio Muscari
Background: α-Mangostin (αMG) is extracted from Garcinia mangostana Linn and exerts antiproliferative activities. Although several researches on αMG were performed using cell monolayers, the in vitro pharmacological effects on 3D cancer models have never been investigated. Aim of the present study was to find new anticancer properties of αMG by evaluating the changes that this compound provokes in multicellular tumour spheroids (MCTSs). Methods: MCTSs were generated from MDA-MB-231 and MCF-7 breast tumour cell lines and then treated with 0...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29333045/in-vitro-antiproliferative-effect-of-earthworm-coelomic-fluid-of-eudrilus-eugeniae-eisenia-foetida-and-perionyx-excavatus-on-squamous-cell-carcinoma-9-cell-line-a-pilot-study
#4
Dominic Augustine, Roopa S Rao, Jayaraman Anbu, K N Chidambara Murthy
Introduction: The earthworm coelomic fluid (ECF) has shown proven antiproliferative effect against breast, liver, gastrointestinal, and brain cancer, but it is least explored in oral cancer. The present in vitro study is an attempt to investigate the antiproliferative activity of ECF on oral cancer cell line squamous cell carcinoma (SCC)-9. Materials and Methods: ECF was collected from the species Eudrilus eugeniae (EE), Eisenia foetida (EF), and Perionyx excavatus (PE) stored at -80°C...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29332356/%C3%AE-aescin-shows-potent-antiproliferative-activity-in-osteosarcoma-cells-by-inducing-autophagy-ros-generation-and-mitochondrial-membrane-potential-loss
#5
Zhao-Rui Liu, Li-Zhi Sun, Tang-Hong Jia, Dao-Fu Jia
PURPOSE: Osteosarcoma is one of the frequent bone tumor affecting mainly children and is associated with considerable mortality. The limited availability of anticancer drugs and less efficacious treatment options have led to poor survival rates of patients with osteosarcoma. Therefore, there is need to look for more viable treatment options and against this backdrop, natural products may prove handy. Therefore the aim of the present study was to evaluate the anticancer activity of a natural product of plant origin, β-aescin, against U2OS human osteosarcoma cells...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29332340/imperatorin-shows-selective-antitumor-effects-in-sgc-7901-human-gastric-adenocarcinoma-cells-by-inducing-apoptosis-cell-cycle-arrest-and-targeting-pi3k-akt-m-tor-signalling-pathway
#6
J U Am, W J Gong, Y Su, Z B Mou
PURPOSE: The main purpose of the present study was to determine the anticancer properties of imperatorin - a naturally occurring coumarin compound - against SGC-7901 human gastric adenocarcinoma cells and the mouse fibroblast cell line 3T3 (normal cell line). METHODS: Imperatorin effects on apoptosis induction, cell cycle phase distribution and PI3K/Akt/m-TOR signalling pathways were studied. MTT cell viability assay examined the compound's cytotoxic potential, while inverted phase contrast microscopy and fluorescence microscopy techniques were used to study morphological changes induced in SGC-7901 cells by imperatorin...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29331315/ethnobotany-phytochemistry-and-pharmacology-of-arctotis-arctotoides-l-f-o-hoffm-a-review
#7
REVIEW
Md Moshfekus Saleh-E-In, Johannes Van Staden
ETHNOPHARMACOLOGICAL RELEVANCE: Arctotis arctotoides (Asteraceae) is part of the genus Arctotis. Arctotis is an African genus of approximately 70 species that occur widely in the African continent with diverse medicinal values. This plant is used for the treatment of indigestion and catarrh of the stomach, epilepsy, topical wounds and skin disorders among the ethnic groups in South Africa and reported to have a wide spectrum of pharmacological properties. AIM OF THE REVIEW: The aim of the present review is to appraise the botany, traditional uses, phytochemistry, pharmacological potential, analytical methods and safety issues of A...
January 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29329644/anticancer-carbazole-alkaloids-and-coumarins-from-clausena-plants-a-review
#8
REVIEW
Li Huang, Zhe-Ling Feng, Yi-Tao Wang, Li-Gen Lin
Pharmaceutical research has focused on the discovery and development of anticancer drugs. Clinical application of chemotherapy drugs is limited due to their severe side effects. In this regard, new naturally occurring anticancer drugs have gained increasing attention because of their potential effectiveness and safety. Fruits and vegetables are promising sources of anticancer remedy. Clausena (family Rutaceae) is a genus of flowering plants and includes several kinds of edible fruits and vegetables. Phytochemical and pharmacological studies show that carbazole alkaloids and coumarins from Clausena plants exhibit anticancer activity...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29316796/scutellaria-baicalensis-and-cancer-treatment-recent-progress-and-perspectives-in-biomedical-and-clinical-studies
#9
Chien-Shan Cheng, Jie Chen, Hor-Yue Tan, Ning Wang, Zhen Chen, Yibin Feng
Scutellaria baicalensis (Huangqin in Chinese) is a major traditional Chinese medicine (TCM) herb, which has a long history of use in the treatment of a variety of symptoms correlated with cancer. In the past decade, the potential of S. baicalensis and single compounds derived from it as anticancer agents targeting various pathways has received extensive research attention. Specifically, the proliferation and metastases inhibiting properties of the single compounds in cancer have been studied; however, the underlying mechanisms remain unclear...
January 9, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29315692/comprehensive-review-of-cardiovascular-toxicity-of-drugs-and-related-agents
#10
REVIEW
Přemysl Mladěnka, Lenka Applová, Jiří Patočka, Vera Marisa Costa, Fernando Remiao, Jana Pourová, Aleš Mladěnka, Jana Karlíčková, Luděk Jahodář, Marie Vopršalová, Kurt J Varner, Martin Štěrba
Cardiovascular diseases are a leading cause of morbidity and mortality in most developed countries of the world. Pharmaceuticals, illicit drugs, and toxins can significantly contribute to the overall cardiovascular burden and thus deserve attention. The present article is a systematic overview of drugs that may induce distinct cardiovascular toxicity. The compounds are classified into agents that have significant effects on the heart, blood vessels, or both. The mechanism(s) of toxic action are discussed and treatment modalities are briefly mentioned in relevant cases...
January 5, 2018: Medicinal Research Reviews
https://www.readbyqxmd.com/read/29303263/antineoplastic-agents-606-the-betulastatins
#11
George R Pettit, Noeleen Melody, Jean-Charles Chapuis
The medicinal potential of the plant pentacyclic triterpene betulin has generated long-term interest focused on various SAR research avenues. The present approach was based on producing further analogues (chimeras) arising from a studied modification of betulin bonded to the Dov-Val-Dil-Dap unit of the powerful anticancer drug dolastatin 10, which provided betulastatins 1 (7b), 2 (11b), 3 (16b), and 4 (18b). Betulastatin 1, 2, and 4 exhibited modest levels of cancer cell growth inhibition against six cancer cell lines...
January 5, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29298657/coumarin-derivatives-as-anticancer-agents-for-lung-cancer-therapy-a-review
#12
Manvendra Kumar, Ramit Singla, Jyoti Dandriyal, Vikas Jaitak
In worldwide lung cancer shares 14% among the newly diagnosed cancer cases. Currently, the numbers of drugs that are in clinical practice are having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand a suitable anticancer drug that has no MDR and side effect. Coumarin scaffold became an attractive subject due to their broad spectrum of pharmacological activities. Coumarin derivatives extensively explored for anticancer activities as it possesses minimum side effect along with multi-drug reversal activity...
December 29, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29288945/recent-advance-in-oxazole-based-medicinal-chemistry
#13
REVIEW
Hui-Zhen Zhang, Zhi-Long Zhao, Cheng-He Zhou
Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic ring are readily able to bind with a variety of enzymes and receptors in biological systems via diverse non-covalent interactions, and thus display versatile biological activities. The related researches in oxazole-based derivatives including oxazoles, isoxazoles, oxazolines, oxadiazoles, oxazolidones, benzoxazoles and so on, as medicinal drugs have been an extremely active topic, and numerous excellent achievements have been acquired...
December 14, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29285635/cellular-pharmacology-studies-of-anticancer-agents-recommendations-from-the-eortc-pamm-group
#14
REVIEW
Paola Perego, Georg Hempel, Stig Linder, Tracey D Bradshaw, Annette K Larsen, Godefridus J Peters, Roger M Phillips
An increasing number of manuscripts focus on the in vitro evaluation of established and novel anti-tumor agents in experimental models. Whilst the design of such in vitro assays is inherently flexible, some of these studies lack the minimum information necessary to critically evaluate their relevance or have been carried out under unsuitable conditions. The use of appropriate and robust methods and experimental design has important implications for generating results that are reliable, relevant, and reproducible...
December 28, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29285029/establishment-and-characterization-of-primary-cultures-from-iranian-oral-squamous-cell-carcinoma-patients-by-enzymatic-method-and-explant-culture
#15
Meysam Ganjibakhsh, Pouyan Aminishakib, Parvaneh Farzaneh, Abbas Karimi, Seyed Abolhassan Shahzadeh Fazeli, Moones Rajabi, Ahmad Nasimian, Fereshteh Baghai Naini, Hedieh Rahmati, Neda Sadat Gohari, Nazanin Mohebali, Masoumeh Asadi, Zahra Elyasi Gorji, Mehrnaz Izadpanah, Shiva Mohamadi Moghanjoghi, Sepideh Ashouri
Objectives: Oral Squamous Cell Carcinoma (OSCC) is the most frequent oral cancer worldwide. It is known as the eighth most common cancer in men and as the fifth most common cancer in women. Cytogenetic and biochemical studies in recent decades have emphasized the necessity of providing an appropriate tool for such researches. Cancer cell culture is a useful tool for investigations on biochemical, genetic, molecular and immunological characteristics of different cancers, including oral cancer...
July 2017: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/29283563/spatial-position-regulates-power-of-tryptophan-discovery-of-major-groove-specific-nuclear-localizing-cell-penetrating-tetrapeptide
#16
Debmalya Bhunia, Prasenjit Mondal, Gaurav Das, Abhijit Saha, Pallabi Sengupta, Jagannath Jana, Saswat Mohapatra, Subhrangsu Chatterjee, Surajit Ghosh
Identification of key amino acids is required for development of efficient cell penetrating peptides (CPPs) and has tremendous implications in medicine. Extensive research work enlightened us about the importance of two amino acids, arginine and tryptophan in the cell penetration. Here, we present a top-down approach to show how spatial po-sitions of two tryptophans regulate the cellular entry and nuclear localization. This enables us to develop short nontoxic tetrapeptides with excellent potential of cell penetration and nuclear localization...
December 28, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29279716/fraxinus-a-plant-with-versatile-pharmacological-and-biological-activities
#17
REVIEW
Iqra Sarfraz, Azhar Rasul, Farhat Jabeen, Tahira Younis, Muhammad Kashif Zahoor, Muhammad Arshad, Muhammad Ali
Fraxinus, a member of the Oleaceae family, commonly known as ash tree is found in northeast Asia, north America, east and western France, China, northern areas of Pakistan, India, and Afghanistan. Chemical constituents of Fraxinus plant include various secoiridoids, phenylethanoids, flavonoids, coumarins, and lignans; therefore, it is considered as a plant with versatile biological and pharmacological activities. Its tremendous range of pharmacotherapeutic properties has been well documented including anticancer, anti-inflammatory, antioxidant, antimicrobial, and neuroprotective...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29278781/isolation-structure-elucidation-and-anticancer-activity-from-brevibacillus-brevis-egs-9-that-combats-multi-drug-resistant-actinobacteria
#18
T Arumugam, P Senthil Kumar, R V Hemavathy, V Swetha, R Karishma Sri
Actinobacteria is the most widely distributed organism in the mangrove environment and produce a large amount of secondary metabolites. A new environmental actinobacterial stain exhibited strong antimicrobial activity against vancomycin and methicillin resistant actinobacteria. The active producer strain was found to be as Brevibacillus brevis EGS9, which was confirmed by its morphological, biochemical characteristics and 16S rRNA gene sequencing. It was deposited in NCBI GeneBank database and received with an accession number of KX388147...
December 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29276967/synergistic-effect-of-pyrazoles-derivatives-and-doxorubicin-in-claudin-low-breast-cancer-subtype
#19
Silvia Saueressig, Josiane Tessmann, Rosiane Mastelari, Liziane Pereira da Silva, Julieti Buss, Natalia Vieira Segatto, Karine Rech Begnini, Bruna Pacheco, Cláudio Martin Pereira de Pereira, Tiago Collares, Fabiana Kömmling Seixas
BACKGROUND: Breast cancer is a global public health problem. For some subtypes, such as Claudin-low, the prognosis is poorer and the treatment is still a challenge. Pyrazoles are an important class of heterocyclic compounds and are promising anticancer agents based on their chemical properties. The present study was aimed not only at testing pyrazoles previously prepared by our research group in two breast cancer cell lines characterized by intermediated response to conventional chemotherapy but also at analyzing the possible synergistic effect of these pyrazoles associated with doxorubicin...
December 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29273489/inflammatory-dermatoses-infections-and-drug-eruptions-are-the-most-common-skin-conditions-in-hospitalized-cancer-patients
#20
Gregory S Phillips, Azael Freites-Martinez, Meier Hsu, Anna Skripnik Lucas, Dulce M Barrios, Kathryn Ciccolini, Michael A Marchetti, Liang Deng, Patricia L Myskowski, Erica H Lee, Alina Markova, Mario E Lacouture
BACKGROUND: Dermatologic conditions cause morbidity and mortality among hospitalized cancer patients. An improved understanding is critical for implementing clinical and research programs in inpatient oncodermatology. OBJECTIVE: To characterize inpatient dermatology consultations at a large comprehensive cancer center. METHODS: Retrospective database query of new admissions and medical record review of initial inpatient dermatology consultations comparing consulted inpatients with non-consulted inpatients from January-December 2015...
December 19, 2017: Journal of the American Academy of Dermatology
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