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https://www.readbyqxmd.com/read/29774137/saudi-anti-human-cancer-plants-database-sacpd-a-collection-of-plants-with-anti-human-cancer-activities
#1
Ateeq Ahmed Al-Zahrani
Several anticancer drugs have been developed from natural products such as plants. Successful experiments in inhibiting the growth of human cancer cell lines using Saudi plants were published over the last three decades. Up to date, there is no Saudi anticancer plants database as a comprehensive source for the interesting data generated from these experiments. Therefore, there was a need for creating a database to collect, organize, search and retrieve such data. As a result, the current paper describes the generation of the Saudi anti-human cancer plants database (SACPD)...
January 30, 2018: Oncology Reviews
https://www.readbyqxmd.com/read/29769480/5-hydroxy-4-nitro-7-propionyloxy-genistein-inhibited-invasion-and-metastasis-via-inactivating-wnt-b-catenin-signal-pathway-in-human-endometrial-carcinoma-ji-endometrial-cells
#2
Jun Bai, Xin Luo
BACKGROUND Chemotherapy has been assuring more important roles in the treatment of carcinoma. Developing new types of drugs with less adverse effects and low drug resistance has become an important researching focus. The present study aimed to investigate the anticancer effects of 5-hydroxy-4'-nitro-7-propionyloxy-genistein (HNPG) and to elucidate its underlying molecular mechanism. MATERIAL AND METHODS The inhibitory effects of cell viability of HNPG were detected using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay, flat plate clone formation method, and Transwell assay...
May 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29768877/decoration-of-a-poly-methyl-vinyl-ether-co-maleic-anhydride-shelled-selol-nanocapsule-with-folic-acid-increases-its-activity-against-different-cancer-cell-lines-in-vitro
#3
Rayane Ganassin, Ludmilla Regina de Souza, Karen Rapp Py-Daniel, João Paulo Figueiró Longo, Janaína Moreira Coelho, Mosar Correa Rodrigues, Cheng-Shi Jiang, Jinsong Gu, Paulo César de Morais, Ewa Mosiniewicz-Szablewska, Piotr Suchocki, Sônia Nair Báo, Ricardo Bentes Azevedo, Luis Alexandre Muehlmann
Due to the low therapeutic index of different chemotherapeutic drugs used for cancer treatment, the development of new anticancer drugs remains an intense field of research. A recently developed mixture of selenitetriacylglycerides, selol, was shown to be active against different cancer cells in vitro. As this compound is highly hydrophobic, it was encapsulated, in a previous study, into poly(methyl vinyl ether-co-maleic anhydride)-shelled nanocapsules in order to improve its dispersibility in aqueous media...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29766787/nanocrystal-technology-as-a-strategy-to-improve-drug-bioavailability-and-antitumor-efficacy-for-the-cancer-treatment
#4
Mingxue Fan, Sicong Geng, Yang Liu, Jing Wang, Yiting Wang, Jian Zhong, Zhiqiang Yan, Lei Yu
BACKGROUND AND OBJECTIVE: Nanocrystal technology is an effective approach which can increase the dissolution rate of poorly water-soluble drugs by raising their saturation solubility, thus improving the drug bioavailability. With the development of nanocrystals, its preparation approaches have gradually matured, which can be generally divided into Bottom-up, Top-down and Combinative technologies. METHODS: A systematic literature review in the field of nanocrystal technology for the cancer treatment was scanned and collected data was detailedly analyzed and summarized...
May 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29765461/anticancer-properties-of-essential-oils-and-other-natural-products
#5
REVIEW
K Blowman, M Magalhães, M F L Lemos, C Cabral, I M Pires
Essential oils are secondary metabolites with a key-role in plants protection, consisting primarily of terpenes with a volatile nature and a diverse array of chemical structures. Essential oils exhibit a wide range of bioactivities, especially antimicrobial activity, and have long been utilized for treating various human ailments and diseases. Cancer cell prevention and cytotoxicity are exhibited through a wide range of mechanisms of action, with more recent research focusing on synergistic and antagonistic activity between specific essential oils major and minor components...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29764209/next-gen-therapeutics-for-skin-cancer-nutraceuticals
#6
Annapoorna Sreedhar, Jun Li, Yunfeng Zhao
Growing modernization and lifestyle changes with limited physical activity have impacted diet and health, leading to an increased cancer mortality rate worldwide. As a result, there is a greater need than before to develop safe and novel anticancer drugs. Current treatment options such as chemotherapy, radiotherapy and surgery, induce unintended side effects, compromising patient's quality of life, and physical well-being. Therefore, there has been an increased global interest in the use of dietary supplements and traditional herbal medicines for treatment of cancer...
May 15, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29757973/a-new-strategy-to-control-and-eradicate-undruggable-oncogenic-k-ras-driven-pancreatic-cancer-molecular-insights-and-core-principles-learned-from-developmental-and-evolutionary-biology
#7
REVIEW
Robert E Van Sciver, Michael P Lee, Caroline Dasom Lee, Alex C Lafever, Elizaveta Svyatova, Kevin Kanda, Amber L Colliver, Lauren L Siewertsz van Reesema, Angela M Tang-Tan, Vasilena Zheleva, Monicah N Bwayi, Minglei Bian, Rebecca L Schmidt, Lynn M Matrisian, Gloria M Petersen, Amy H Tang
Oncogenic K-RAS mutations are found in virtually all pancreatic cancers, making K-RAS one of the most targeted oncoproteins for drug development in cancer therapies. Despite intense research efforts over the past three decades, oncogenic K-RAS has remained largely "undruggable". Rather than targeting an upstream component of the RAS signaling pathway (i.e., EGFR/HER2) and/or the midstream effector kinases (i.e., RAF/MEK/ERK/PI3K/mTOR), we propose an alternative strategy to control oncogenic K-RAS signal by targeting its most downstream signaling module, Seven-In-Absentia Homolog (SIAH)...
May 14, 2018: Cancers
https://www.readbyqxmd.com/read/29755619/molecularly-targeted-therapy-for-the-oral-cancer-stem-cells
#8
REVIEW
Yuichi Ohnishi, Hiroki Yasui, Masami Nozaki, Masahiro Nakajima
Human cancer tissues are heterogeneous in nature and become differentiated during expansion of cancer stem cells (CSCs). CSCs initiate tumorigenesis, and are involved in tumor recurrence and metastasis. Furthermore, data show that CSCs are highly resistant to anticancer drugs. Cetuximab, a specific anti-epidermal growth factor receptor (EGFR) monoclonal antibody, is used in cancer treatment. Although development of resistance to cetuximab is well recognized, the underlying mechanisms remain unclear. Lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR)/ErbB2, has antiproliferative effects and is used to treat patients with ErbB2-positive metastatic breast cancer...
May 2018: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29755542/design-synthesis-and-antitubercular-evaluation-of-novel-series-of-pyrazinecarboxamide-metal-complexes
#9
Mohsin Ali, Mansoor Ahmed, Saleem Hafiz, Mustafa Kamal, Majid Mumtaz, Seyed Abdulmajid Ayatollahi
The interest in the synthesis of metallic complexes of different drugs to make them more efficient in biological environment of the human body is seen for the last few decades. Wide range of metal complexes are already used in clinical practice which encourages additional research for innovating new metal based drugs, such as metal-mediated antibiotics, anti-parasitic, antiviral, antibacterial, and anticancer compounds. Tuberculosis has been known as one of the most disastrous disease putting burden on health system worldwide...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29749524/multifaceted-regulation-and-functions-of-yap-taz-in-tumors-review
#10
Huirong Liu, Suya Du, Tiantian Lei, Hailian Wang, Xia He, Rongsheng Tong, Yi Wang
The Hippo pathway, initially identified through screenings for mutant tumor suppressors in Drosophila, is an evolutionarily conserved signaling pathway that controls organ size by regulating cell proliferation and apoptosis. Abnormal regulation of the Hippo pathway may lead to cancer in mammals. As the major downstream effectors of the Hippo pathway, unphosphorylated Yes-associated protein (YAP) and its homolog transcriptional co-activator TAZ (also called WWTR1) (hereafter called YAP/TAZ) are translocated into the nucleus...
May 8, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29745324/internal-and-external-triggering-mechanism-of-smart-nanoparticle-based-ddss-in-targeted-tumor-therapy
#11
Xian-Ling Qiana, Jun Li, Ran Wei, Hui Lin, Li-Xia Xiong
BACKGROUND: Anticancer chemotherapeutics have a lot of problems via conventional drug delivery systems (DDSs), including non-specificity, burst release, severe side-effects, and damage to normal cells. Owing to its potential to circumventing these problems, nanotechnology has gained increasing attention in targeted tumor therapy. Chemotherapeutic drugs or genes encapsulated in nanoparticles could be used to target therapies to the tumor site in three ways: "passive", "active", and "smart" targeting...
May 9, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29737298/a-preliminary-study-on-the-anticancer-efficacy-of-caulis-spatholobi-compound-1802
#12
Yingnan Cao, Qiling Tang, Lan Luo, Ziying Gao, Suzhong Zhang
In recent years, antitumor and antiviral effect of Caulis spatholobi becomes a hot topic of medical drug research. Experiment shows that the water extract of Caulis spatholobi compound 1802 showed the effect of inhibiting tumor growth, the difference was statistically significant (P<0.05); the rate of tumor inhibition was highest in the high dose group of compound 1802, which could reach 41.99%. Anti tumor drugs generally have high toxicity, therefore, low toxicity is the significant characteristic of Caulis spatholobi...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29736277/why-miltefosine-a-life-saving-drug-for-leishmaniasis-is-unavailable-to-people-who-need-it-the-most
#13
REVIEW
Temmy Sunyoto, Julien Potet, Marleen Boelaert
Miltefosine, the only oral drug approved for the treatment of leishmaniasis-a parasitic disease transmitted by sandflies-is considered as a success story of research and development (R&D) by a public-private partnership (PPP). It epitomises the multiple market failures faced by a neglected disease drug: patients with low ability to pay, neglect by authorities and uncertain market size. Originally developed as an anticancer agent in the 1990s, the drug was registered in India in 2002 to treat the fatal visceral leishmaniasis...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29735465/a-preliminary-study-on-the-anticancer-efficacy-of-caulis-spatholobi-compound-1802
#14
Yingnan Cao, Qiling Tang, Lan Luo, Ziying Gao, Suzhong Zhang
In recent years, antitumor and antiviral effect of Caulis spatholobi becomes a hot topic of medical drug research. Experiment shows that the water extract of Caulis spatholobi compound 1802 showed the effect of inhibiting tumor growth, the difference was statistically significant (P<0.05); the rate of tumor inhibition was highest in the high dose group of compound 1802, which could reach 41.99%. Anti tumor drugs generally have high toxicity, therefore, low toxicity is the significant characteristic of Caulis spatholobi...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29728233/multifunctional-chitosan-capped-gold-nanoparticles-for-enhanced-cancer-chemo-radiotherapy-an-invitro-study
#15
Mohamed Mahmoud Fathy, Fayrouz S Mohamed, NihalSaad Elbialy, Wael M Elshemey
Over the last decade, chemo-radiotherapy represented a well-established paradigm for cancer treatment. Developing new strategies to promote the therapeutic efficacy while reducing toxic side effects of chemo-radiotherapy is a main research objective in cancer therapy. A promising new oncological strategy for enhancing chemo-radiotherapy against cancer involves the utilization of multifunctional nanoparticles (nanocarriers and radiosensitizers). In this work, Chitosan-Capped Gold Nanoparticles (CS-GNPs) were synthesized and loaded with an anticancer agent, Doxorubicin (CS-GNPs-DOX)...
April 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29725260/micrornas-associated-with-therapy-of-non-small-cell-lung-cancer
#16
REVIEW
Junmi Lu, Yuting Zhan, Juan Feng, Jiadi Luo, Songqing Fan
The incidence of non-small cell lung cancer (NSCLC) has been rising over the past several decades. Despite various therapeutic regimens and modern diagnostic techniques are developed, NSCLC still have an extremely poor prognosis due to drug resistance. Therefore, it is critical to find a novel precise diagnosis and effective treatment approach for NSCLC patients. MicroRNAs (MiRNAs) are a class of 18-25nt non-coding small RNAs, which have been shown to be involved profoundly in the pathogenesis such as cellular proliferation, differentiation, development, apoptosis and tumorigenesis in many human tumors including of NSCLC...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29722635/recent-and-future-advances-in-anticancer-drug-delivery-an-interview-with-khaled-greish
#17
Khaled Greish
Khaled Greish speaks to Hannah Makin, Commissioning Editor: Khaled Greish is Associate Professor of Molecular Medicine, and head of the Nano-research unit, at Princes Al-Jawhara Center, Arabian Gulf University, Kingdom of Bahrain. His previous appointments included Senior lecturer of Pharmacology at the University of Otago, New Zealand, and Assistant Professor of Pharmaceutical Chemistry at University of Utah (UT, USA). He has published >70 peer reviewed papers, and ten book chapters in the field of targeted anticancer drug delivery...
May 1, 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29721403/nanostructured-surfaces-for-analysis-of-anticancer-drug-and-cell-diagnosis-based-on-electrochemical-and-sers-tools
#18
REVIEW
Waleed A El-Said, Jinho Yoon, Jeong-Woo Choi
Discovering new anticancer drugs and screening their efficacy requires a huge amount of resources and time-consuming processes. The development of fast, sensitive, and nondestructive methods for the in vitro and in vivo detection of anticancer drugs' effects and action mechanisms have been done to reduce the time and resources required to discover new anticancer drugs. For the in vitro and in vivo detection of the efficiency, distribution, and action mechanism of anticancer drugs, the applications of electrochemical techniques such as electrochemical cell chips and optical techniques such as surface-enhanced Raman spectroscopy (SERS) have been developed based on the nanostructured surface...
2018: Nano Convergence
https://www.readbyqxmd.com/read/29719138/mannose-and-mannose-6-phosphate-receptor-targeted-drug-delivery-systems-and-their-application-in-cancer-therapy
#19
REVIEW
Elena Dalle Vedove, Gabriella Costabile, Olivia M Merkel
In order to overcome the main disadvantages of conventional cancer therapies, which prove to be inadequate because of their lack of selectivity, the development of targeted delivery systems is one of the main focuses in anticancer research. It is repeatedly shown that decorating the surface of nanocarriers with high-affinity targeting ligands, such as peptides or small molecules, is an effective way to selectively deliver therapeutics by enhancing their specific cellular uptake via the binding between a specific receptor and the nanosystems...
May 2, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29717305/in-situ-semi-quantitative-assessment-of-single-cell-viability-by-resonance-raman-spectroscopy
#20
Zhu Mao, Zhuo Liu, Jin Yang, Xiaoxia Han, Bing Zhao, Chun Zhao
Currently, studies are increasingly focusing on the cytotoxic effects of anticancer drugs. Such investigations urgently warrant the assessment of single-cell viability. Here, we developed a novel method for quantifying single-cell viability with high selectivity by resonance Raman scattering. We report on this powerful tool that will allow researchers to study cellular metabolism at the level of a single cell.
May 2, 2018: Chemical Communications: Chem Comm
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