keyword
https://read.qxmd.com/read/38537162/advancing-bone-targeted-drug-delivery-leveraging-biological-factors-and-nanoparticle-designs-to-improve-therapeutic-efficacy
#1
JOURNAL ARTICLE
Baixue Xiao, Marian A Ackun-Farmmer, Emmanuela Adjei-Sowah, Yuxuan Liu, Indika Chandrasiri, Danielle S W Benoit
Designing targeted drug delivery systems to effectively treat bone diseases ranging from osteoporosis to nonunion bone defects remains a significant challenge. Previously, nanoparticles (NPs) self-assembled from diblock copolymers of poly(styrene- alt -maleic anhydride)- b -poly(styrene) (PSMA- b -PS) delivering a Wnt agonist were shown to effectively target bone and improve healing via the introduction of a peptide with high affinity to tartrate-resistant acid phosphatase (TRAP), an enzyme deposited by the osteoclasts during bone remodeling...
March 27, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38535706/static-magnetic-field-enhances-the-bone-remodelling-capacity-of-human-demineralized-bone-matrix-in-a-rat-animal-model-of-cranial-bone-defects
#2
JOURNAL ARTICLE
SeyedJamal Hosseini, Houman Parsaei, MirJavad Moosavifar, Narjes Tavakoli, Reza Ahadi, Kaveh Roshanbinfar
The regeneration of bone defects that exceed 2 cm is a challenge for the human body, necessitating interventional therapies. Demineralized bone matrices (DBM) derived from biological tissues have been employed for bone regeneration and possess notable osteoinductive and osteoconductive characteristics. Nevertheless, their efficiency in regenerating critically sized injuries is limited, and therefore additional signaling cues are required. Thanks to the piezoelectric properties of the bone, external physical stimulation is shown to accelerate tissue healing...
March 27, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38535259/bone-marrow-derived-mesenchymal-stem-cell-laden-nanocomposite-scaffolds-enhance-bone-regeneration-in-rabbit-critical-size-segmental-bone-defect-model
#3
JOURNAL ARTICLE
Elangovan Kalaiselvan, Swapan Kumar Maiti, Shivaraju Shivaramu, Shajahan Amitha Banu, Khan Sharun, Divya Mohan, Sangeetha Palakkara, Sadhan Bag, Monalisa Sahoo, Suresh Ramalingam, Jürgen Hescheler
Bone regeneration poses a significant challenge in the field of tissue engineering, prompting ongoing research to explore innovative strategies for effective bone healing. The integration of stem cells and nanomaterial scaffolds has emerged as a promising approach, offering the potential to enhance regenerative outcomes. This study focuses on the application of a stem cell-laden nanomaterial scaffold designed for bone regeneration in rabbits. The in vivo study was conducted on thirty-six healthy skeletally mature New Zealand white rabbits that were randomly allocated into six groups...
March 10, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535247/active-and-passive-mineralization-of-bio-gide-%C3%A2-membranes-in-rat-calvaria-defects
#4
JOURNAL ARTICLE
Karol Ali Apaza Alccayhuaman, Patrick Heimel, Stefan Tangl, Stefan Lettner, Carina Kampleitner, Layla Panahipour, Ulrike Kuchler, Reinhard Gruber
Bio-Gide® is a collagen membrane routinely used in guided bone regeneration. Recent studies have shown that this collagen membrane has osteoconductive properties, meaning that it can support the growth of new bone. However, it has also been observed that the collagen membrane has areas of mineralized fibers which can occur spontaneously and independently of osteoblasts. To better understand how this works, we established a model using minced collagen membranes to reduce the active mineralization of intact collagen membranes in favor of passive mineralization...
February 21, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535015/congenital-heart-defects-in-patients-with-molecularly-confirmed-sotos-syndrome
#5
JOURNAL ARTICLE
Giulio Calcagni, Federica Ferrigno, Alessio Franceschini, Maria Lisa Dentici, Rossella Capolino, Lorenzo Sinibaldi, Chiara Minotti, Alessia Micalizzi, Viola Alesi, Antonio Novelli, Anwar Baban, Giovanni Parlapiano, Domenico Coviello, Paolo Versacci, Carolina Putotto, Marcello Chinali, Fabrizio Drago, Andrea Bartuli, Bruno Marino, Maria Cristina Digilio
Sotos syndrome is an autosomal dominant condition characterized by overgrowth with advanced bone age, macrodolicocephaly, motor developmental delays and learning difficulties, and characteristic facial features caused by heterozygous pathogenetic variants in the NSD1 gene located on chromosome 5q35. The prevalence of heart defects (HDs) in individuals with Sotos syndrome is estimated to be around 15-40%. Septal defects and patent ductus arteriosus are the most commonly diagnosed malformations, but complex defects have also been reported...
March 11, 2024: Diagnostics
https://read.qxmd.com/read/38534838/recent-advances-in-scaffolds-for-guided-bone-regeneration
#6
REVIEW
Theodoros-Filippos Valamvanos, Xanthippi Dereka, Hector Katifelis, Maria Gazouli, Nefeli Lagopati
The rehabilitation of alveolar bone defects of moderate to severe size is often challenging. Currently, the therapeutic approaches used include, among others, the guided bone regeneration technique combined with various bone grafts. Although these techniques are widely applied, several limitations and complications have been reported such as morbidity, suboptimal graft/membrane resorption rate, low structural integrity, and dimensional stability. Thus, the development of biomimetic scaffolds with tailor-made characteristics that can modulate cell and tissue interaction may be a promising tool...
March 1, 2024: Biomimetics
https://read.qxmd.com/read/38534561/the-impact-of-defect-size-on-bone-healing-in-critical-size-bone-defects-investigated-on-a-rat-femur-defect-model-comparing-two-treatment-methods
#7
JOURNAL ARTICLE
Andreas Kammerer, Frederik Alexander Hartmann, Christoph Nau, Maximilian Leiblein, Alexander Schaible, Jonas Neijhoft, Dirk Henrich, René Verboket, Maren Janko
Critical-size bone defects up to 25 cm can be treated successfully using the induced membrane technique established by Masquelet. To shorten this procedure, human acellular dermis (HAD) has had success in replacing this membrane in rat models. The aim of this study was to compare bone healing for smaller and larger defects using an induced membrane and HAD in a rat model. Using our established femoral defect model in rats, the animals were placed into four groups and defects of 5 mm or 10 mm size were set, either filling them with autologous spongiosa and surrounding the defect with HAD or waiting for the induced membrane to form around a cement spacer and filling this cavity in a second operation with a cancellous bone graft...
March 19, 2024: Bioengineering
https://read.qxmd.com/read/38534533/three-dimensional-printing-of-drug-eluting-implantable-plga-scaffolds-for-bone-regeneration
#8
JOURNAL ARTICLE
Manjusha Annaji, Nur Mita, Ishwor Poudel, Sai H S Boddu, Oladiran Fasina, R Jayachandra Babu
Despite rapid progress in tissue engineering, the repair and regeneration of bone defects remains challenging, especially for non-homogenous and complicated defects. We have developed and characterized biodegradable drug-eluting scaffolds for bone regeneration utilizing direct powder extrusion-based three-dimensional (3D) printing techniques. The PLGA scaffolds were fabricated using poly (lactic-co-glycolic acid) (PLGA) with inherent viscosities of 0.2 dl/g and 0.4 dl/g and ketoprofen. The effect of parameters such as the infill, geometry, and wall thickness of the drug carrier on the release kinetics of ketoprofen was studied...
March 6, 2024: Bioengineering
https://read.qxmd.com/read/38534489/comparative-analysis-of-bone-regeneration-according-to-particle-type-and-barrier-membrane-for-octacalcium-phosphate-grafted-into-rabbit-calvarial-defects
#9
JOURNAL ARTICLE
Se-Wook Pyo, Jeong-Won Paik, Da-Na Lee, Young-Wook Seo, Jin-Young Park, Sunjai Kim, Seong-Ho Choi
This animal study was aimed to evaluate the efficacy of new bone formation and volume maintenance according to the particle type and the collagen membrane function for grafted octacalcium phosphate (OCP) in rabbit calvarial defects. The synthetic bone substitutes were prepared in powder form with 90% OCP and granular form with 76% OCP, respectively. The calvarial defects were divided into four groups according to the particle type and the membrane application. All specimens were acquired 2 weeks (n = 5) and 8 weeks (n = 5) after surgery...
February 24, 2024: Bioengineering
https://read.qxmd.com/read/38534300/in-vivo-evaluation-of-regenerative-osteogenic-potential-using-a-human-demineralized-dentin-matrix-for-dental-application
#10
JOURNAL ARTICLE
Nessma Sultan, Soher Nagi Jayash
BACKGROUND: The use of a demineralized dentin matrix (DDM) has garnered substantial importance in dentistry. This study was carried out to evaluate the osteoinductive performance of DDM in comparison to nano-hydroxyapatite (n-HA) on calvarial critical-sized bone defect. METHODS: Two critical-sized defects (CSDs) were bilaterally trephined in the calvarium of sixteen healthy white rabbits. The rabbits were categorized into four groups: in group 1, the defect was left empty; in group 2, defects were filled with sodium alginate (SA) hydrogel as a sole material; in group 3, defects were treated with nano-hydroxyapatite hydrogel (NHH); in group 4, defects were treated using demineralized dentin matrix hydrogel (DDMH)...
March 18, 2024: Dentistry Journal
https://read.qxmd.com/read/38534275/biological-effects-of-orthodontic-tooth-movement-on-the-periodontium-in-regenerated-bone-defects-a-scoping-review
#11
REVIEW
Alessio Verdecchia, Carlota Suárez-Fernández, Andrea Miquel, Giulia Bardini, Enrico Spinas
The aim of this scoping review is to analyse the biological effects of the orthodontic tooth movement (OTM) in areas with bone defects that are undergoing regeneration using different types of regenerative materials and techniques. The electronic research was performed on four databases as follows: PubMed, Scopus, EMBASE, and Web of Science. Data were extracted according to publication information, study design, sample characteristics, parameters of OTM, biological repercussions on the periodontium complex, methods of analysis, and conclusions...
February 26, 2024: Dentistry Journal
https://read.qxmd.com/read/38534217/development-of-aav-mediated-gene-therapy-approaches-to-treat-skeletal-diseases
#12
JOURNAL ARTICLE
Chujiao Lin, Matthew Greenblatt, Guangping Gao, Jae-Hyuck Shim
Adeno-associated viral (AAV) vectors have emerged as crucial tools in advancing gene therapy for skeletal diseases, offering the potential for sustained expression with low post-infection immunogenicity and pathogenicity. Preclinical studies support both the therapeutic efficacy and safety of these vectors, illustrating the promise of AAV-mediated gene therapy. Emerging technologies and innovations in AAV-mediated gene therapy strategies, such as gene addition, gene replacement, gene silencing, and gene editing, offer new approaches to clinical application...
March 27, 2024: Human Gene Therapy
https://read.qxmd.com/read/38534197/additive-manufacturing-of-wet-spun-poly-3-hydroxybutyrate-co-3-hydroxyvalerate-based-scaffolds-loaded-with-hydroxyapatite
#13
JOURNAL ARTICLE
Gianni Pecorini, Simona Braccini, Stefano Simoni, Andrea Corti, Gianluca Parrini, Dario Puppi
Tissue engineering represents an advanced therapeutic approach for the treatment of bone tissue defects. Polyhydroxyalkanoates (PHAs) is a promising class of natural polymers in this context thanks to their biocompatibility, processing versatility, and mechanical properties. The aim of this study is the development by computer-aided wet-spinning of novel poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)-based composite scaffolds for bone engineering. In particular, PHBV scaffolds are loaded with hydroxyapatite (HA), an osteoinductive ceramic, in order to tailor their biological activity and mechanical properties...
March 27, 2024: Macromolecular Bioscience
https://read.qxmd.com/read/38533771/head-and-neck-reconstruction-with-the-superficial-circumflex-iliac-artery-perforator-scip-free-flap-lessons-learned-after-73-cases
#14
JOURNAL ARTICLE
Mario F Scaglioni, Matteo Meroni, Patrick E Tomasetti, Gunesh P Rajan
BACKGROUND: Head and neck tissue defects after ablative surgery often require complex and composite reconstructions. The superficial circumflex iliac artery perforator (SCIP) flap is an extremely versatile perforator-based flap with minimal donor site morbidity, which may represent the optimal procedure in this setting. Over the last 5 years, we collected a large base of experience, including both simple and chimeric SCIP-based reconstruction, making this flap our first choice for head and neck reconstructions...
March 27, 2024: Head & Neck
https://read.qxmd.com/read/38533625/aspirin-loaded-anti-inflammatory-zno-sio-2-aerogel-scaffolds-for-bone-regeneration
#15
JOURNAL ARTICLE
Yue Zhao, Caiqi Cheng, Xinyi Wang, Zhengchao Yuan, Binbin Sun, Mohamed El-Newehy, Meera Moydeen Abdulhameed, Bing Fang, Xiumei Mo
The increasing aging of the population has elevated bone defects to a significant threat to human life and health. Aerogel, a biomimetic material similar to an extracellular matrix (ECM), is considered an effective material for the treatment of bone defects. However, most aerogel scaffolds suffer from immune rejection and poor anti-inflammatory properties and are not well suited for human bone growth. In this study, we used electrospinning to prepare flexible ZnO-SiO2 nanofibers with different zinc concentrations and further assembled them into three-dimensional composite aerogel scaffolds...
March 27, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38533146/less-is-more-a-case-report-on-all-on-4-prosthesis
#16
Dhanashree A Minase, Seema Sathe, Anjali Borle, Ankita Pathak, Tanvi Jaiswal
Severe alveolar ridge atrophy following tooth removal poses a common and worsening issue in edentulous jaws, affecting patient comfort and quality of life. The All-on-4 approach involves axially positioning two anterior implants and distally orienting two posterior implants, reducing cantilever length and enabling prostheses with 12 teeth. This less invasive option, utilizing distal tilting of implants at 30°, offers biomechanical advantages and has shown short-term success, though long-term research is limited...
February 2024: Curēus
https://read.qxmd.com/read/38532711/infection-microenvironment-responsive-coating-on-titanium-surfaces-for-on-demand-release-of-therapeutic-gas-and-antibiotic
#17
JOURNAL ARTICLE
Kun Wang, Fan Rong, Haowei Peng, Zhang Yuan, Jingjing Huo, Pengxiang Liu, Rui Ding, Cuiping Yan, Guming Liu, Tengjiao Wang, Peng Li
Aseptic loosening and bacterial infection pose significant challenges in the clinical application of titanium (Ti) orthopedic implants, which are primarily caused by insufficient osseointegration and bacterial contamination. To address these issues, we constructed a responsive coating on Ti surface, which achieved enhanced osseointegration and infection elimination by on-demand release of therapeutic gas hydrogen sulfide (H2 S) and antibiotic. TiO2 nanotubes (TNT) were anodized on the Ti surface to enhance its bioactivity and serve as reservoirs for the antibiotic...
March 27, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38532349/inhibition-of-zdhhc16-promoted-osteogenic-differentiation-and-reduced-ferroptosis-of-dental-pulp-stem-cells-by-creb
#18
JOURNAL ARTICLE
Wei Liu, Wenwei Yu, Lili Zhou, Danhua Ling, Yangbo Xu, Fuming He
BACKGROUND: The repair of bone defects caused by periodontal diseases is a difficult challenge in clinical treatment. Dental pulp stem cells (DPSCs) are widely studied for alveolar bone repair. The current investigation aimed to examine the specific mechanisms underlying the role of Zinc finger DHHC-type palmitoyl transferases 16 (ZDHHC16) in the process of osteogenic differentiation (OD) of DPSCs. METHODS: The lentiviral vectors ZDHHC16 or si-ZDHHC16 were introduced in the DPSCs and then the cells were induced by an odontogenic medium for 21 days...
March 26, 2024: BMC Oral Health
https://read.qxmd.com/read/38532155/customised-pre-operative-cranioplasty-to-achieve-maximal-surgical-resection-of-tumours-with-osseous-involvement-a-case-series
#19
JOURNAL ARTICLE
Swati Jain, Adel Helmy, Thomas Santarius, Nicola Owen, Kirsty Grieve, Peter Hutchinson, Ivan Timofeev
PURPOSE: Surgical resection with bony margins would be the treatment of choice for tumours with osseous involvement such as meningiomas and metastasis. By developing and designing pre-operative customised 3D modelled implants, the patient can undergo resection of meningioma and repair of bone defect in the same operation. We present a generalisable method for designing pre-operative cranioplasty in patients to repair the bone defect after the resection of tumours. MATERIALS AND METHODS: We included six patients who presented with a tumour that was associated with overlying bone involvement...
March 27, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38531790/mechanical-stretch-induced-atp-release-from-osteocytes-promotes-osteogenesis-of-bone-marrow-mesenchymal-stem-cells
#20
JOURNAL ARTICLE
Yiwen Ru, Hong Gu, Lian Sun, WeiBing Zhang, Lin Wang
BACKGROUND: Mandibular distraction osteogenesis (MDO) is a highly effective method for bone regeneration, commonly employed in treating craniofacial defects and deformities. Osteocytes sense mechanical forces in the pericellular space, relay external stimuli to biochemical changes, and send signals to other effector cells, including bone marrow mesenchymal stem cells (BM-MSCs), to regulate bone resorption and formation. Piezo1 potentially affects the secretion signal molecules of bone cells under mechanical stretch...
March 2024: Discovery Medicine
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