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three dimensional printing

Christen J Boyer, Jennifer E Woerner, Christopher Galea, Corbin A Gatlin, Ghali E Ghali, David K Mills, Jeffery A Weisman, Jonathan S Alexander
PURPOSE: After cleft lip and palate surgical procedures, patients often need nostril supports to help the reconstructed nostrils retain their shape during healing. Many postoperative nasal stents use a one-size-fits-all approach, in which a standard rubber tube retainer is trimmed and used to support the healing nares. The purpose of this study was to examine photogrammetry and 3-dimensional (3D) printing as a fabrication tool for postoperative patient-specific nasal supports that can be loaded with bioactive agents for localized delivery...
March 28, 2018: Journal of Oral and Maxillofacial Surgery
Qi Gu, Eva Tomaskovic-Crook, Gordon G Wallace, Jeremy M Crook
Bioprinting provides an opportunity to produce three-dimensional (3D) tissues for biomedical research and translational drug discovery, toxicology, and tissue replacement. Here we describe a method for fabricating human neural tissue by 3D printing human neural stem cells with a bioink, and subsequent gelation of the bioink for cell encapsulation, support, and differentiation to functional neurons and supporting neuroglia. The bioink uniquely comprises the polysaccharides alginate, water-soluble carboxymethyl-chitosan, and agarose...
2018: Methods in Molecular Biology
Astrid M Hoving, Joep Kraeima, Rutger H Schepers, Hildebrand Dijkstra, Jan Hendrik Potze, Bart Dorgelo, Max J H Witjes
BACKGROUND: MRI is the optimal method for sensitive detection of tumour tissue and pre-operative staging in oral cancer. When jawbone resections are necessary, the current standard of care for oral tumour surgery in our hospital is 3D virtual planning from CT data. 3D printed jawbone cutting guides are designed from the CT data. The tumour margins are difficult to visualise on CT, whereas they are clearly visible on MRI scans. The aim of this study was to change the conventional CT-based workflow by developing a method for 3D MRI-based lower jaw models...
2018: PloS One
Mojun Chen, Zhaoyi Xu, Jung Hyun Kim, Seung Kwon Seol, Ji Tae Kim
Exploiting a femtoliter liquid meniscus formed on a nanopipette is a powerful approach to spatially control mass transfer or chemical reaction at the nanoscale. However, the insufficient reliability of techniques for the meniscus formation still restricts its practical use. We report on a noncontact, programmable method to produce a femtoliter liquid meniscus that is utilized for parallel three-dimensional (3D) nanoprinting. The method based on electrohydrodynamic dispensing enables one to create an ink meniscus at a pipette-substrate gap without physical contact and positional feedback...
April 19, 2018: ACS Nano
Esmaeil Biazar, Masoumeh Najafi S, Saeed Heidari K, Meysam Yazdankhah, Ataollah Rafiei, Dariush Biazar
In the last decade, the use of new technologies in the reconstruction of body tissues has greatly developed. Utilising stem cell technology, nanotechnology and scaffolding design has created new opportunities in tissue regeneration. The use of accurate engineering design in the creation of scaffolds, including 3D printers, has been widely considered. Three-dimensional printers, especially high precision bio-printers, have opened up a new way in the design of 3D tissue engineering scaffolds. In this article, a review of the latest applications of this technology in this promising area has been addressed...
April 19, 2018: Journal of Medical Engineering & Technology
Peng Peng, Yafei Xu, Xintao Zhang, Meisong Zhu, Bingran Du, Wenrui Li, Wenhua Huang, Jun Song, Jianyi Li
BACKGROUND: This study aimed to develop patient-specific drill templates by computer numerical control or three-dimensional printing via two cortical bone trajectories (CBTs) and to evaluate their efficacies and accuracies in cervical anterior transpedicular insertion. METHODS: Preoperative CT images of 20 cadaveric cervical vertebrae (C3-C7) were obtained. After image processing, patient-specific drill templates were randomly assigned to be constructed via two CBTs (CBT0 and CBT0...
April 18, 2018: Journal of Orthopaedic Surgery and Research
Robert J Morrison, Hassan B Nasser, Khaled N Kashlan, David A Zopf, Derek J Milner, Colleen L Flanangan, Matthew B Wheeler, Glenn E Green, Scott J Hollister
OBJECTIVES/HYPOTHESIS: Reconstruction of craniofacial cartilagenous defects are among the most challenging surgical procedures in facial plastic surgery. Bioengineered craniofacial cartilage holds immense potential to surpass current reconstructive options, but limitations to clinical translation exist. We endeavored to determine the viability of utilizing adipose-derived stem cell-chondrocyte co-culture and three-dimensional (3D) printing to produce 3D bioscaffolds for cartilage tissue engineering...
April 18, 2018: Laryngoscope
(no author information available yet)
Shinoda K, Matsushita T, Nakamura Y, et al. HLA-DRB1*04:05 allele is associated with intracortical lesions on three-dimensional double inversion recovery images in Japanese patients with multiple sclerosis. Mult Scler. Epub ahead of print 5 May 2017. DOI: 10.1177/1352458517707067.
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
Ling Li, Jing Long, Long Li, Huijuan Cao, Tingting Tang, Xinghua Xi, Ling Qin, Yuxiao Lai, Xinluan Wang
Background/Objective: A novel porous scaffold poly (lactide- co -glycolide) and tricalcium phosphate (PLGA/TCP) was developed by three-dimensional printing technology for bone defect repair. As a Class 2 solvent with less severe toxicity, content of residual 1,4-dioxane in this newly developed scaffold should be rigorously controlled when it is translated to clinical use. In this study, a headspace gas chromatography-mass spectrometric (HS-GC-MS) method and related testing protocol were developed for quantitative determination of 1,4-dioxane in the PLGA/TCP composite scaffolds...
April 2018: Journal of Orthopaedic Translation
Hyun Jin Park, Chenyu Wang, Kyung Ho Choi, Hyong Nyun Kim
BACKGROUND: Training beginners of the pedicle screw instrumentation technique in the operating room is limited because of issues related to patient safety and surgical efficiency. Three-dimensional (3D) printing enables training or simulation surgery on a real-size replica of deformed spine, which is difficult to perform in the usual cadaver or surrogate plastic models. The purpose of this study was to evaluate the educational effect of using a real-size 3D-printed spine model for training beginners of the free-hand pedicle screw instrumentation technique...
April 16, 2018: Journal of Orthopaedic Surgery and Research
Yan Chang, Lin Deng, Xiaoyang Meng, Wen Zhang, Chunzhen Wang, Yuxin Wang, Song Zhao, Li Lin, John C Crittenden
Developing effective technologies for treatment of spent etchant in printed circuit boards industries is of paramount for sustainable copper reuse and reducing copper discharge. We developed a novel closed-loop electrochemical cell for on-site regeneration of spent acidic cupric chloride etchant. It does not have any emissions and recycles all the copper using a three-dimensional graphite felt anode decorated with carbon nanotube (CNT/GF). The CNT/GF anode oxidizes Cu(I) to Cu(II) so that the spent cuprous chloride can be converted to cupric chloride and reused...
April 16, 2018: Environmental Science & Technology
Shweta AnilKumar, Shane C Allen, Nishat Tasnim, Tahmina Akter, Shinhye Park, Alok Kumar, Munmun Chattopadhyay, Yoshihiro Ito, Laura J Suggs, Binata Joddar
Three-dimensional bioprinting is an innovative technique in tissue engineering, to create layer-by-layer structures, required for mimicking body tissues. However, synthetic bioinks do not generally possess high printability and biocompatibility at the same time. So, there is an urgent need for naturally derived bioinks that can exhibit such optimized properties. We used furfuryl-gelatin as a novel, visible-light crosslinkable bioink for fabricating cell-laden structures with high viability. Hyaluronic acid was added as a viscosity enhancer and either Rose Bengal or Riboflavin was used as a visible-light crosslinker...
April 15, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Nicolette S Birbara, James M Otton, Nalini Pather
BACKGROUND: A comprehensive knowledge of mitral valve (MV) anatomy is crucial in the assessment of MV disease. While the use of three-dimensional (3D) modelling and printing in MV assessment has undergone early clinical evaluation, the precision and usefulness of this technology requires further investigation. This study aimed to assess and validate 3D modelling and printing technology to produce patient-specific 3D MV models. METHODS: A prototype method for MV 3D modelling and printing was developed from computed tomography (CT) scans of a plastinated human heart...
November 10, 2017: Heart, Lung & Circulation
Xiao-Li Guo, Yan Wei, Qi Lou, Ying Zhu, Qun Fang
Herein, we developed an automated and flexible system for performing miniaturized liquid-liquid reactions and assays in the femtoliter to picoliter range, by combining the contact printing and the droplet-based microfluidics techniques. The system mainly consisted of solid pins and an oil-covered hydrophilic micropillar array chip fixed on an automated x- y- z translation stage. A novel droplet manipulation mode called "dipping-depositing-moving" (DDM) was proposed, which was based on the programmable combination of three basic operations, dipping liquids and depositing liquids with the solid pins and moving the two-dimensional oil-covered hydrophilic pillar microchip...
April 12, 2018: Analytical Chemistry
Sarah Bastawrous, Nicole Wake, Dmitry Levin, Beth Ripley
Improvements in technology and reduction in costs have led to widespread interest in three-dimensional (3D) printing. 3D-printed anatomical models contribute to personalized medicine, surgical planning, and education across medical specialties, and these models are rapidly changing the landscape of clinical practice. A physical object that can be held in one's hands allows for significant advantages over standard two-dimensional (2D) or even 3D computer-based virtual models. Radiologists have the potential to play a significant role as consultants and educators across all specialties by providing 3D-printed models that enhance clinical care...
April 4, 2018: Abdominal Radiology
Jonas Lölsberg, John Linkhorst, Arne Cinar, Alexander Jans, Alexander J C Kuehne, Matthias Wessling
Microfluidics is an established multidisciplinary research domain with widespread applications in the fields of medicine, biotechnology and engineering. Conventional production methods of microfluidic chips have been limited to planar structures, preventing the exploitation of truly three-dimensional architectures for applications such as multi-phase droplet preparation or wet-phase fibre spinning. Here the challenge of nanofabrication inside a microfluidic chip is tackled for the showcase of a spider-inspired spinneret...
April 5, 2018: Lab on a Chip
Chee Kai Chua, Wai Yee Yeong, Jia An
Only a handful of materials are well-established in three-dimensional (3D) printing and well-accepted in industrial manufacturing applications. However, recent advances in 3D printable materials have shown potential for enabling numerous novel applications in the future. This special issue, consisting of 2 reviews and 10 research articles, intends to explore the possible materials that could define next-generation 3D printing.
April 4, 2018: Materials
Ji-Young Sim, Yeon Jang, Woong-Chul Kim, Hae-Young Kim, Dong-Hwan Lee, Ji-Hwan Kim
PURPOSE: This study aimed to evaluate and compare the accuracy. METHODS: A reference model was prepared with three prepared teeth for three types of restorations: single crown, 3-unit bridge, and inlay. Stone models were fabricated from conventional impressions. Digital impressions of the reference model were created using an intraoral scanner (digital models). Physical models were fabricated using a three-dimensional (3D) printer. Reference, stone, and 3D printed models were subsequently scanned using an industrial optical scanner; files were exported in a stereolithography file format...
March 31, 2018: Journal of Prosthodontic Research
Xingwei Tang, Han Zhou, Zuocheng Cai, Dongdong Cheng, Peisheng He, Peiwen Xie, Di Zhang, Tongxiang Fan
Graphene-based mixed-dimensional materials hybridization is important for a myriad of applications. However, conventional manufacturing techniques face critical challenges in producing arbitrary geometries with programmable features, continuous interior networks, and multimaterials homogeneity. Here we propose a generalized three-dimensional (3D) printing methodology for graphene aerogels and graphene-based mixed-dimensional (2D + nD, where n is 0, 1, or 2) hybrid aerogels with complex architectures, by the development of hybrid inks and printing schemes to enable mix-dimensional hybrids printability, overcoming the limitations of multicomponents inhomogeneity and harsh post-treatments for additives removal...
April 5, 2018: ACS Nano
Badreddine Ratni, Jianjia Yi, Xumin Ding, André de Lustrac, Kuang Zhang, Gérard-Pascal Piau, Shah Nawaz Burokur
A metal-dielectric-metal gradient phase partially reflecting surface based on the combination of a gradient index dielectric substrate with an inductive and a capacitive grids, is designed at microwave frequencies for antenna applications. The gradient index is obtained by realizing air holes of different dimensions in a dielectric host material. A prototype of the gradient index dielectric substrate is fabricated through three-dimensional printing, an additive fabrication technology. It is then associated to two patterned metallic grids to realize a partially reflecting surface with a gradient phase behavior...
March 19, 2018: Optics Express
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