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https://www.readbyqxmd.com/read/28221731/identifying-a-conceptual-shift-in-child-and-adolescent-reported-treatment-decision-making-having-a-say-as-i-need-at-this-time
#1
Katherine Patterson Kelly, Catriona Mowbray, Kimberly Pyke-Grimm, Pamela S Hinds
BACKGROUND: Professional organizations and governments recommend child and adolescent involvement in cancer treatment decision making (TDM) despite minimal evidence that children prefer involvement, how best to include them, and the result of doing so. PROCEDURE: Using descriptive qualitative research methods, we interviewed 20 children ages 9-17 years about their TDM preferences and experiences. We shifted our conceptualizations as findings emerged about how children with cancer viewed their decisional experiences...
April 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28199895/a-rapid-and-robust-uhplc-dad-method-for-the-quantification-of-amphotericin-b-in-human-plasma
#2
Sebastiano Barco, Alessia Zunino, Antonio D'Avolio, Laura Barbagallo, Angelo Maffia, Gino Tripodi, Elio Castagnola, Giuliana Cangemi
Amphotericin B is an antifungal drug widely used in Intensive Care Units. Therapeutic drug monitoring (TDM) of amphotericin B is recommended for the assessment of toxicity surveillance and treatment optimization. In this paper we described the development and validation of a new Ultra High Performance Liquid Chromatography coupled to Diode Array Detection (UHPLC-DAD) method for the quantification of Amphotericin B in 200μL human plasma over a wide range of concentrations (0.125-10mg/L). The new method has been validated following international guidelines on bioanalytical method validation and showed high selectivity, high accuracy and precision and high process efficiency...
February 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28198096/treated-dentin-matrix-paste-as-a-novel-pulp-capping-agent-for-dentin-regeneration
#3
Jinlong Chen, Caiyun Cui, Xiangchen Qiao, Bo Yang, Mei Yu, Weihua Guo, Weidong Tian
Regenerating dentin and preserving pulp vitality are the two key targets for the treatment of dental pulp exposure. Calcium hydroxide (CH), the widely used capping agent, may induce potential tunnel defect in reparative dentin and cause inflammation or even necrosis in pulp tissues. This study aimed to produce a novel pulp capping agent with better bioactivities. Treated dentin matrix (TDM) paste (TDMP) was fabricated consisting of TDM powder and aqueous TDM extract. The chemical and biological characteristics of TDMP were investigated, and its effect on the odontogenic differentiation of dental pulp stem cells explored at gene and protein level; the therapeutic effect for pulp exposure in miniature swine was further verified...
February 15, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28183252/pharmacological-profile-and-pharmacogenomics-of-anti-cancer-drugs-used-for-targeted-therapy
#4
Raffaele Di Francia, Angela De Monaco, Mariangela Saggese, Giancarla Iaccarino, Stefania Crisci, Ferdinando Frigeri, Rosaria De Filippi, Massimiliano Berretta, Antonio Pinto
Drugs for targeted therapies are primarily Small Molecules Inhibitors (SMIs), monoclonal antibodies (mAbs), interfering RNA molecules and microRNA. The use of these new agents generates a multifaceted step in the pharmacokinetics (PK) of these drugs. Individual PK variability is often large, and unpredictability observed in the response to the pharmacogenetic profile of the patient (e.g. cytochome P450 enzyme), patient characteristics such as adherence to treatment and environmental factors. Objective This review aims to overview the latest anticancer drugs eligible for targeted therapies and the most recent finding in pharmacogenomics related to toxicity/resistance because either individual gene polymorphisms or acquired mutation in a cancer cell...
February 8, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28182078/difference-in-antibody-responses-to-mycobacterium-tuberculosis-antigens-in-japanese-tuberculosis-patients-infected-with-the-beijing-non-beijing-genotype
#5
Jingge Zhao, Beata Shiratori, Masao Okumura, Hideki Yanai, Makoto Matsumoto, Chie Nakajima, Kazue Mizuno, Kenji Ono, Tetsuya Oda, Haorile Chagan-Yasutan, Yugo Ashino, Takashi Matsuba, Takashi Yoshiyama, Yasuhiko Suzuki, Toshio Hattori
The Beijing genotype Mycobacterium tuberculosis (MTB), notorious for its virulence and predisposition to relapse, could be identified by spoligotyping based on genetic heterogeneity. The plasma samples from 20 cases of Beijing and 16 cases of non-Beijing MTB infected individuals and 24 healthy controls (HCs) were collected, and antibodies against 11 antigens (Rv0679c142Asn, Rv0679c142Lys, Ag85B, Ag85A, ARC, TDM-M, TDM-K, HBHA, MDP-1, LAM, and TBGL) were measured by ELISA. Compared to the HCs, the MTB infected subjects showed higher titers of anti-Ag85B IgG (positivity 58...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28177134/the-influence-of-combination-use-of-cyp450-inducers-on-the-pharmacokinetics-of-voriconazole-a-systematic-review
#6
REVIEW
T-Y Li, W Liu, K Chen, S-Y Liang, F Liu
WHAT IS KNOWN AND OBJECTIVES: Voriconazole is a triazole antifungal agent and is extensively metabolized via cytochrome P450 (CYP450); therefore, special precautions need to be taken when co-administered with a known CYP450 inducer, which may lead to treatment failure. The influence of some CYP450 inducers on the pharmacokinetics of voriconazole has been described in previous studies, but a systematic review was lacking. In this study, we carried out a systematic review to assess the influence of CYP450 inducers on the pharmacokinetic (PK) parameters of voriconazole...
February 8, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28169862/quantification-of-acetaminophen-and-its-metabolites-in-plasma-using-uplc-ms-doors-open-to-therapeutic-drug-monitoring-in-special-patient-populations
#7
Robert B Flint, Paola Mian, Bart van der Nagel, Nuria Slijkhuis, Birgit C P Koch
BACKGROUND: Acetaminophen (APAP, paracetamol) is the most commonly used drug for pain and fever in both the United States and Europe and considered safe when used at registered dosages. Nevertheless, differences between specific populations lead to remarkable changes in exposure to potentially toxic metabolites. Furthermore, extended knowledge is required on metabolite formation following intoxication, to optimize antidote treatment. Therefore, the authors aimed to develop and validate a quick and easy analytical method for simultaneous quantification of APAP, APAP-glucuronide, APAP-sulfate, APAP-cysteine, APAP-glutathione, APAP-mercapturate, and protein-derived APAP-cysteine in human plasma by ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-MS/MS)...
February 6, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28167419/comparative-pharmacokinetic-profiles-of-selected-irreversible-tyrosine-kinase-inhibitors-neratinib-and-pelitinib-with-apigenin-in-rat-plasma-by-uplc-ms-ms
#8
Hadir M Maher, Nourah Z Alzoman, Shereen M Shehata, Ashwag O Abahussain
Neratinib (NER) and pelitinib (PEL) are irreversible tyrosine kinase inhibitors (TKIs) that have been recently employed in cancer treatment. Apigenin (API), among other flavonoids, is known to have antioxidant, anti-proliferative, and carcinogenic effect. API can potentiate the antitumor effect of chemotherapeutic agents and/or alleviate the side effects of many anticancer agents. Since TKIs are mostly metabolized by CYP3A4 enzymes and that API could alter the enzymatic activity, potential drug interactions could be expected following their co-aministration...
January 31, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28165282/oral-recombinant-human-or-mouse-lactoferrin-reduces-mycobacterium-tuberculosis-tdm-induced-granulomatous-lung-pathology
#9
Shen-An Hwang, Marian L Kruzel, Jeffrey K Actor
Trehalose 6'6-dimycolate (TDM) is the most abundant glycolipid on the cell wall of Mycobacterium tuberculosis (MTB). TDM is capable of inducing granulomatous pathology in mouse models that resembles those induced by MTB infection. Using the acute TDM model, this work investigates the effect of recombinant human and mouse lactoferrin to reduce granulomatous pathology. C57BL/6 mice were injected intravenously with TDM at a dose of 25 μg·mouse(-1). At day 4 and 6, recombinant human or mouse lactoferrin (1 mg·(100 μL)(-1)·mouse(-1)) were delivered by gavage...
February 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28159368/estimation-of-adsorption-isotherm-and-mass-transfer-parameters-in-protein-chromatography-using-artificial-neural-networks
#10
Gang Wang, Till Briskot, Tobias Hahn, Pascal Baumann, Jürgen Hubbuch
Mechanistic modeling has been repeatedly successfully applied in process development and control of protein chromatography. For each combination of adsorbate and adsorbent, the mechanistic models have to be calibrated. Some of the model parameters, such as system characteristics, can be determined reliably by applying well-established experimental methods, whereas others cannot be measured directly. In common practice of protein chromatography modeling, these parameters are identified by applying time-consuming methods such as frontal analysis combined with gradient experiments, curve-fitting, or combined Yamamoto approach...
March 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28157956/tdm-interrogation-of-intensity-modulated-usfbgs-network-based-on-multichannel-lasers
#11
Jalal Rohollahnejad, Li Xia, Rui Cheng, Yanli Ran, Udaya Rahubadde, Jiaao Zhou, Lin Zhu
We report a large-scale multi-channel fiber sensing network, where ultra-short FBGs (USFBGs) instead of conventional narrow-band ultra-weak FBGs are used as the sensors. In the time division multiplexing scheme of the network, each grating response is resolved as three adjacent discrete peaks. The central wavelengths of USFBGs are tracked with the differential detection, which is achieved by calculating the peak-to-peak ratio of two maximum peaks. Compared with previous large-scale hybrid multiplexing sensing networks (e...
January 23, 2017: Optics Express
https://www.readbyqxmd.com/read/28153282/utilizing-online-dual-spe-lc-with-hrms-for-the-simultaneous-quantification-of-amphotericin-b-fluconazole-and-fluorocytosine-in-human-plasma-and-cerebrospinal-fluid
#12
Lihua Qu, Jing Qian, Ping Ma, Zheng Yin
Amphotericin B (AMB), fluconazole (FZ), and fluorocytosine (FC) are recommended for HIV-associated cryptococcal meningitis (CM) patients as preferred antibiotics. This study presents a fast and automated online-dual-solid phase extraction (SPE)-LC coupled with high resolution mass spectrometer (HRMS) method to simultaneously measure the concentrations of AMB, FZ, and FC in human plasma and cerebrospinal fluid (CSF). Automated sample clean-up was performed on the human plasma and CSF samples with stop-flow heart-cutting two dimensional (2D) separation using a online-dual-SPE system, allowing retention and accumulation of AMB, FZ, and carbamazepine (CBZ, Internal standard (IS)) by the Oasis(®)HLB cartridge, and retention and accumulation of FC and 5-methylcytosine hydrochloride (MC, IS) by the HyperSep Hypercarb cartridge respectively...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28152826/patient-and-clinician-perspectives-on-treatment-decision-making-for-african-american-men-with-prostate-cancer
#13
Sarah Abramson, Daniel Walker, Lindsey Sova, Jenny J Lin, Kezhen Fei, Rebeca Franco, Ann Scheck McAlearney
: 186 Background: Prostate cancer is the most common cancer for men in the US, yet the burden of this disease falls disproportionately on African Americans (AAs). The disparity's etiology is complex. Surgery and radiotherapy offer similar survival but historically have different rates of performance with younger and white men more likely to undergo surgery and AAs more likely to experience underuse. This study aims to examine treatment decision-making (TDM) processes for AA men from patient and physician perspectives...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28145574/drug-drug-interaction-between-valproic-acid-and-meropenem-a-retrospective-analysis-of-electronic-medical-records-from-neurosurgery-inpatients
#14
Z-P Wen, S-S Fan, C Du, T Yin, B-T Zhou, Z-F Peng, Y-Y Xie, W Zhang, Y Chen, J Xiao, X-P Chen
WHAT IS KNOWN AND OBJECTIVE: A series of studies have indicated that valproic acid (VPA) plasma concentration decreased rapidly when used concomitantly with carbapenem antibiotics, including meropenem (MEPM), imipenem and panipenem, which may increase the risk of seizure breakthrough. However, the cause for the change in VPA pharmacokinetics is unclear. A retrospective analysis of VPA therapeutic drug monitoring (TDM) records was performed to investigate this VPA pharmacokinetics drug-drug interaction...
February 1, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28143591/a-case-report-of-intravenous-posaconazole-in-hepatic-and-renal-impairment-patient-with-invasive-aspergillus-terreus-infection-safety-and-role-of-therapeutic-drug-monitoring
#15
Pitchaya Dilokpattanamongkol, Panadda Panusitthikorn, Rasda Boonprasert, Methee Chayakulkeeree, Porpon Rotjanapan
BACKGROUND: Invasive aspergillosis (IA) is a fatal infectious complication among immunocompromised patients. Aspergillus terreus, the fourth common species can be difficult to treat due to a unique resistance pattern. To date, there has been no report on safety and dose adjustment when intravenous posaconazole is selected in hepatic and renal impairment patient. We present a rare case of intravenous posaconazole use in a hepatic and renal impairment patient with invasive A. terreus pulmonary infection...
January 31, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28140598/modulation-of-the-la-lb-mixing-in-an-indole-derivative-a-position-dependent-study-using-4-5-and-6-fluoroindole
#16
Josefin Wilke, Martin Wilke, Christian Brand, J Dominik Spiegel, Christel M Marian, Michael Schmitt
The lowest two electronically excited singlet states of indole and its derivatives are labeled as La or Lb, based on the orientation of the transition dipole moment (TDM) and the magnitude of the permanent electric dipole moment. Rotationally resolved electronic Stark spectroscopy in combination with high level ab initio calculations offers the possibility to determine these characteristics and thus the electronic nature of the excited states. In the present contribution this approach was pursued for the systems 4- and 6-fluoroindole and the results compared to the previously investigated system 5-fluoroindole...
February 14, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28131674/milrinone-therapeutic-drug-monitoring-in-a-pediatric-population-development-and-validation-of-a-quantitative-liquid-chromatography-tandem-mass-spectrometry-method
#17
Joshua E Raizman, Katherine Taylor, Christopher Parshuram, David A Colantonio
BACKGROUND: Milrinone is a potent selective phosphodiesterase type III inhibitor which stimulates myocardial function and improves myocardial relaxation. Although therapeutic monitoring is crucial to maintain therapeutic outcome, little data is available. A proof-of-principle study has been initiated in our institution to evaluate the clinical impact of optimizing milrinone dosing through therapeutic drug monitoring (TDM) in children following cardiac surgery. We developed a robust LC-MS/MS method to quantify milrinone in serum from pediatric patients in real-time...
January 25, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28126443/quantification-of-meropenem-in-human-plasma-by-hilic-tandem-mass-spectrometry
#18
Jens Martens-Lobenhoffer, Stefanie M Bode-Böger
Meropenem is a substance from the carbapenem class of antibiotics. It is widely used in intensive care units to treat a broad range of severe bacterial infections. In this critically ill patient group therapeutic drug monitoring (TDM) is highly advisable in order to avoid under- as well as over-dosing. Here, we describe a HILIC-MS/MS method for the quantification of meropenem in human plasma which is suitable for TDM. After simple protein precipitation, the polar analyte was chromatographically separated by the HILIC mechanism on a silica based stationary phase with polyethylenimide coating...
January 19, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28125504/therapeutic-drug-monitoring-of-everolimus-comparability-of-concentrations-determined-by-two-immunoassays-and-a-lc-ms-ms-method
#19
Maria Shipkova, Sonja Rapp, Raül Rigo-Bonnin, Eberhard Wieland, Andreas Peter
BACKGROUND: Therapeutic drug monitoring (TDM) is recommended to guide therapy with the immunosuppressant Everolimus (EVL) in solid organ transplantation to prevent rejections and to limit toxicity. For TDM, pre-dose EVL concentrations are measured in whole blood mainly by liquid chromatography tandem mass spectrometry (LC-MS/MS). In addition, two immunoassays (QMS® Everolimus and Elecsys® Everolimus) are commercially available. The aim of this study was to evaluate the comparability of EVL results determined with the two immunoassays and a validated LC-MS/MS test using samples from kidney (KT)-liver (LT)- and heart (HT) transplant recipients...
January 24, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28125503/measurement-of-clozapine-norclozapine-and-amisulpride-in-plasma-and-in-oral-fluid-obtained-using-two-different-sampling-systems
#20
Danielle S Fisher, Chad Beyer, Gerrit van Schalkwyk, Soraya Seedat, Robert J Flanagan
BACKGROUND: There is a poor correlation between total concentrations of proton-accepting compounds (most basic drugs) in unstimulated oral fluid and in plasma. The aim of this study was to compare clozapine, norclozapine, and amisulpride concentrations in plasma and in oral fluid collected using commercially available collection devices [ThermoFisher Scientific Oral-Eze and Greiner Bio-One (GBO)]. METHODS: Oral-Eze and GBO samples and plasma were collected in that order from patients prescribed clozapine...
January 24, 2017: Therapeutic Drug Monitoring
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