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https://www.readbyqxmd.com/read/28921675/altered-cav1-2-function-in-the-timothy-syndrome-mouse-model-produces-ascending-serotonergic-abnormalities
#1
Daniel G Ehlinger, Kathryn G Commons
Polymorphism in the gene CACNA1C, encoding the pore-forming subunit of Cav1.2 L-type calcium channels, has one of the strongest genetic linkages to schizophrenia, bipolar disorder, and major depressive disorder: psychopathologies in which serotonin signaling has been implicated. Additionally, a gain-of-function mutation in CACNA1C is responsible for the neurodevelopmental disorder Timothy Syndrome that presents with prominent behavioral features on the autism spectrum. Given an emerging role for serotonin in the etiology of autism spectrum disorders, we investigate the relationship between Cav1...
September 16, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28921589/susceptibility-behaviour-and-retention-of-the-parasitic-salmon-louse-lepeophtheirus-salmonis-differ-with-atlantic-salmon-population-origin
#2
S Bui, S Dalvin, T Dempster, O F Skulstad, R B Edvardsen, A Wargelius, F Oppedal
Atlantic salmon populations across the world have diverse ecological and evolutionary histories, from wild anadromous or landlocked, to domestication and genetic modification. The natural host behaviours confer protection from infestation by ectoparasitic salmon lice Lepeophtheirus salmonis, yet whether genetic origin results in different behaviours and thus susceptibility to infestation is unknown. In common garden experiments, we tested antiparasite behaviours, susceptibility and retention of salmon lice in wild anadromous, wild landlocked, domesticated and genetically modified domesticated strains...
September 17, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28921570/behavioural-responses-of-infective-stage-copepodids-of-the-salmon-louse-lepeophtheirus-salmonis-copepoda-caligidae-to-host-related-sensory-cues
#3
D M Fields, A B Skiftesvik, H I Browman
The salmon louse (Lepeophtheirus salmonis [Krøyer]) is an ectoparasitic copepod that causes disease in farmed Atlantic salmon (Salmo salar) and may play a role in the decline of some wild salmonid populations. Controlling lice infestations is a major cost for the salmon industry; this has stimulated the pursuit of alternative approaches to controlling them. One such approach involves determining, and then disrupting, the sensory cues used by the parasite to find its host. In this context, we examined the behavioural responses of lice copepodids to light flicker-simulating light reflecting from the sides of the salmon host and/or the shadows cast by fish passing overhead-and water-soluble chemicals released from the skin of the salmon...
September 17, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28920966/-prevention-of-cardiovascular-diseases-prophylactic-program-in-a-selected-enterprise
#4
Jadwiga Siedlecka, Elżbieta Gadzicka, Agata Szyjkowska, Patryk Siedlecki, Wiesław Szymczak, Teresa Makowiec-Dąbrowska, Alicja Bortkiewicz
BACKGROUND: In Poland cardiovascular diseases (CVD), classified as work-related diseases, are responsible for 25% of disability and cause 50% of all deaths, including 26.9% of deaths in people aged under 65 years. The aim of the study was to analyze employee expectations regarding CVD- oriented prophylactic activities in the selected enterprise. MATERIAL AND METHODS: A questionnaire, developed for this study, consists of: socio-demographic data, job characteristics, occupational factors, and questions about the respondents' expectations concerning the prevention program...
September 18, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28920103/existence-of-brain-5-ht1a-5-ht2a-isoreceptor-complexes-with-antagonistic-allosteric-receptor-receptor-interactions-regulating-5-ht1a-receptor-recognition
#5
Dasiel O Borroto-Escuela, Xiang Li, Alexander O Tarakanov, David Savelli, Manuel Narváez, Kirill Shumilov, Yuniesky Andrade-Talavera, Antonio Jimenez-Beristain, Bartosz Pomierny, Zaida Díaz-Cabiale, Riccardo Cuppini, Patrizia Ambrogini, Maria Lindskog, Kjell Fuxe
Studies on serotonin-selective reuptake inhibitors have established that disturbances in the ascending 5-HT neuron systems and their 5-HT receptor subtypes and collateral networks to the forebrain contribute to the etiology of major depression and are targets for treatment. The therapeutic action of serotonin-selective reuptake inhibitors is of proven effectiveness, but the mechanisms underlying their effect are still unclear. There are many 5-HT subtypes involved; some need to be blocked (e.g., 5-HT2A, 5-HT3, and 5-HT7), whereas others need to be activated (e...
August 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/28919863/oxygen-uptake-kinetics-is-slower-in-swimming-than-arm-cranking-and-cycling-during-heavy-intensity
#6
Ana Sousa, Fabio Borrani, Ferran A Rodríguez, Grégoire P Millet
Oxygen uptake ([Formula: see text]) kinetics has been reported to be influenced by the activity mode. However, only few studies have compared [Formula: see text]O2 kinetics between activities in the same subjects in which they were equally trained. Therefore, this study compared the [Formula: see text]O2 kinetics response to swimming, arm cranking, and cycling within the same group of subjects within the heavy exercise intensity domain. Ten trained male triathletes (age 23.2 ± 4.5 years; height 180.8 ± 8...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28919494/shoulder-injury-in-water-polo-a-systematic-review-of-incidence-and-intrinsic-risk-factors
#7
REVIEW
Andrea H Miller, Kerrie Evans, Roger Adams, Gordon Waddington, Jeremy Witchalls
OBJECTIVES: Water polo is a popular water-based contact sport that involves swimming, throwing and defending. Cumulatively, these repetitive overhead activities are thought to increase the risk of shoulder injury and, subsequently to affect players' physical conditioning as well as team performance. The purpose of this review was to examine available evidence relating to shoulder injury rates and risk factors for shoulder injury in water polo. DESIGN: Systematic review METHODS: CINAHL, AUSPORT, Pubmed, Pedro and SPORTDiscus databases were searched for original research papers using the predefined terms ("water polo") AND (shoulder OR glenohumeral* OR arm OR "upper limb")...
August 31, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28919044/susceptibility-of-colistin-resistant-pathogens-to-predatory-bacteria
#8
Sonal Dharani, Dong Hyun Kim, Robert M Q Shanks, Yohei Doi, Daniel E Kadouri
The increase in multidrug-resistant Gram-negative bacterial infections has forced the reintroduction of antibiotics such as colistin. However, the spread of plasmid-borne mcr-1 colistin resistance genes have moved us closer to an era of untreatable Gram-negative infections. To evaluate whether predatory bacteria could be used as a potential therapeutic to treat this upcoming threat, the ability of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus to prey on several clinically relevant mcr-1-positive, colistin-resistant isolates was evaluated...
September 14, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28918338/a-short-term-swimming-speed-alteration-test-with-nauplii-of-artemia-franciscana
#9
Silvia Morgana, Noelia Estévez-Calvar, Chiara Gambardella, Marco Faimali, Francesca Garaventa
The presence of toxicant needs to be assessed within short time in order to effectively protect the aquatic environment from serious threat. Based on the observation that at high temperatures aquatic organisms become more vulnerable to stressors than those maintained at room temperature, a new test was developed. The proposed bioassay consisted in the evaluation of the swimming speed alteration (SSA) of nauplii of Artemia franciscana incubated at 39°C (± 1) for 6h, using a Swimming Behavior Recorder system (SBR)...
September 14, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28917709/in-vitro-interactions-of-acanthamoeba-castellanii-neff-and-vibrio-harveyi
#10
María Reyes-Batlle, Alberto J Martín-Rodríguez, Atteneri López-Arencibia, Ines Sifaoui, Aitor Rizo Liendo, Carlos J Bethencourt Estrella, Ana B García Méndez, Olfa Chiboub, Soumaya Hajaji, Basilio Valladares, Enrique Martínez-Carretero, José E Piñero, Jacob Lorenzo-Morales
Free-living amoebae (FLA) are opportunistic protozoa widely distributed in the environment. They are frequently found in water and soil samples, but they have also been reported to be associated with bacterial human pathogens such as Legionella spp. Campylobacter spp or Vibrio cholerae among others. Including within Vibrio spp. V. harveyi (Johnson and Shunk, 1936) is a bioluminescent marine bacteria which has been found swimming freely in tropical marine waters, being part of the stomach and intestine microflora of marine animals, and as both a primary and opportunistic pathogen of marine animals...
September 13, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28917361/immediate-effects-of-pilates-based-therapeutic-exercise-on-postural-control-of-young-individuals-with-non-specific-low-back-pain-a-randomized-controlled-trial
#11
Susana Lopes, Christophe Correia, Gonçalo Félix, Mário Lopes, Ana Cruz, Fernando Ribeiro
OBJECTIVES: Low back pain affects the person's ability to keep balance, especially in challenging conditions. The purpose of this study was to determine the immediate effects of Pilates exercises on postural sway and dynamic balance of young individuals with non-specific low back pain. DESIGN: Controlled laboratory design. SETTINGS AND MAIN OUTCOME MEASURES: Forty-six participants with non-specific low back pain were randomized to a Pilates (n=23, 10 males; age: 21...
October 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28916706/the-expression-of-ldh-c-in-the-skeletal-muscle-of-plateau-pika-ochotona-curzoniae-enhances-adaptation-to-a-hypoxic-environment
#12
Zhi F An, Deng B Wei, Lian Wei, Yang Wang, Lin N Wei
The plateau pika (Ochotona curzoniae) is a species of sprint-running alpine animals in the Qinghai-Tibet Plateau, which is a harsh highland hypoxic environment. Ldh-c is expressed in the testis, sperm and somatic tissues of plateau pika. To reveal the role and physiological mechanisms of sperm-specific lactate dehydrogenase (LDH-C4), in plateau pika to adapt to hypoxic environment, an adenoviral line of pMultiRNAi-Ldhc was constructed and injected into the bilateral biceps femoris of the hind legs. The swimming times of the pikas, and the Ldh-c expression levels, total LDH activities and ATP levels in skeletal muscle, were measured after the pikas were raised in the trapped site for 5 days...
September 15, 2017: Biology Open
https://www.readbyqxmd.com/read/28916452/symbolic-dynamics-of-animal-interaction
#13
Maurizio Porfiri, Manuel Ruiz Marín
Since its introduction nearly two decades ago, transfer entropy has contributed to an improved understanding of cause-and-effect relationships in coupled dynamical systems from raw time series. In the context of animal behavior, transfer entropy might help explain the determinants of leadership in social groups and elucidate escape response to predator attacks. Despite its promise, the potential of transfer entropy in animal behavior is yet to be fully tested, and a number of technical challenges in information theory and statistics remain open...
September 12, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28916441/monoamine-involvement-in-the-antidepressant-like-effect-induced-by-p2-blockade
#14
Cassiano Raf Diniz, Murilo Rodrigues, Plínio C Casarotto, Vítor S Pereira, Carlos C Crestani, Sâmia Rl Joca
Depression is a common mental disorder that affects millions of individuals worldwide. Available monoaminergic antidepressants are far from ideal since they show delayed onset of action and are ineffective in approximately 40% of patients, thus indicating the need of new and more effective drugs. ATP signaling through P2 receptors seems to play an important role in neurophatological mechanisms involved in depression, since their pharmacological or genetic inactivation induce antidepressant-like effects in the forced swimming test (FST)...
September 12, 2017: Brain Research
https://www.readbyqxmd.com/read/28916358/the-functional-characterization-and-comparison-of-two-single-crd-containing-c-type-lectins-with-novel-and-typical-key-motifs-from-portunus-trituberculatus
#15
Mengmeng Huang, Changkao Mu, Yuehong Wu, Fei Ye, Dan Wang, Cong Sun, Zhengbing Lv, Bingnan Han, Chunlin Wang, Xue-Wei Xu
C-type lectins are a superfamily of Ca(2+)-dependent carbohydrate-recognition proteins, which play crucial roles in innate immunity including nonself-recognition and pathogen elimination. In the present study, two single-CRD containing C-type lectins were identified from swimming crab Portunus trituberculatus (designated as PtCTL-2 and PtCTL-3). The open reading frame (ORF) of PtCTL-2 encoded polypeptides of 485 amino acids with a signal peptide and a single carbohydrate-recognition domain (CRD), while PtCTL-3's ORF encoded polypeptides of 241 amino acids with a coiled-coil region and a single-CRD...
September 12, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28916331/depressive-like-phenotype-induced-by-prenatal-dexamethasone-in-mice-is-reversed-by-desipramine
#16
Mirko Conti, Stefan Spulber, Marilena Raciti, Sandra Ceccatelli
Exposure to prenatal insults has been associated with an increased risk for neuropsychiatric disorders, including depression, but the mechanisms are still poorly understood. Persistent alterations of the HPA axis feedback mechanism as well as adult impaired neurogenesis are believed to play a relevant role in the etiology of depression. In addition, growing evidence points at epigenetic reprogramming as a key factor. We have previously shown that prenatal exposure to the synthetic glucocorticoid dexamethasone (DEX) impairs neurogenesis and leads to late onset of depression-like behavior that does not respond to the SSRI antidepressant fluoxetine (FLX)...
September 12, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28916283/deuterated-d6-dextromethorphan-elicits-antidepressant-like-effects-in-mice
#17
Linda Nguyen, Anna L Scandinaro, Rae R Matsumoto
The over-the-counter antitussive dextromethorphan (DM) may have rapid antidepressant actions based on its overlapping pharmacology with ketamine, which has shown fast antidepressant effects but whose widespread use remains limited by problematic side effects. We have previously shown that DM produces antidepressant-like effects in the forced swim test (FST) and tail suspension test (TST) that are mediated in part through α-amino-3-hydroxy-5-methyl-4-isoxazole propionic (AMPA) and sigma-1 receptors, two protein targets associated with a faster onset of antidepressant efficacy...
September 12, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28915388/epa-and-dha-but-not-ala-have-antidepressant-effects-with-17%C3%AE-estradiol-injection-via-regulation-of-a-neurobiological-system-in-ovariectomized-rats
#18
Jeong-Eun Choi, Yongsoon Park
Our previous studies found that n-3 polyunsaturated fatty acids (PUFAs) and estrogen had synergistic antidepressant-like effects. The purpose of the present study was to investigate the hypothesis that three major n-3 PUFAs, α-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), individually had antidepressant effects combined with 17β-estradiol-3-benzoate (E) through a neurobiological pathway in ovariectomized rats. Rats were fed a modified American Institute of Nutrition-93G diet with 0% n-3 PUFAs and 1% ALA, EPA and DHA relative to total energy intake for 12 weeks and were injected with corn oil or E every 4 days during the last 3 weeks...
August 5, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28915131/body-mass-index-and-saltwater-drowning
#19
Roger W Byard
Comparison of body mass index (BMI) was undertaken between 30 cases of salt water drowning and 30 age- and sex-matched controls randomly selected from the autopsy files of Forensic Science SA, Adelaide, Australia, during the period 2000 to 2017. The age range of drowning cases and controls was 18 to 80 (average, 49) years, with a male to female ratio of 19:11. The BMIs of the drowning cases ranged from 15.5 to 37.5 (average, 25.4; median, 23). The control cases had higher BMIs ranging from 22.9 to 44.3 (average, 29...
September 14, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28914562/the-effect-of-regular-aquatic-exercise-on-blood-pressure-a-meta-analysis-of-randomized-controlled-trials
#20
Yutaka Igarashi, Yoshie Nogami
Background No meta-analysis has examined the effect of regular aquatic exercise on blood pressure. The purpose of this study was to perform a meta-analysis to evaluate the effects of regular aquatic exercise on blood pressure. Design A meta-analysis of randomized controlled trials. Methods Databases were searched for literature published up to April 2017. The randomized controlled trials analysed involved healthy adults, an intervention group that only performed aquatic exercise and a control group that did not exercise, no other intervention, and trials indicated mean systolic blood pressure or diastolic blood pressure...
January 1, 2017: European Journal of Preventive Cardiology
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