Read by QxMD icon Read

maternal separation

Sarah M Holmen, Tiki Bakhshi, Maria M Molina, Larissa F Weir
BACKGROUND: Chorioamniotic membrane separation (CMS) is a rare finding that is commonly preceded by invasive fetal procedures. The presence of CMS can also be associated with uncommon maternal or fetal conditions as well as preterm delivery, amniotic band syndrome, umbilical cord complications, and fetal and neonatal death. It is classified as a high-risk antepartum condition due to the significant fetal morbidity and mortality that may ensue. CASE REPORT: A 40-year-old gravida 5 para 1212 at 35 weeks presented for antepartum fetal testing...
October 2016: Military Medicine
Annamagreth M Mukwenda, Columba K Mbekenga, Andrea B Pembe, Pia Olsson
BACKGROUND: Eclampsia is a major cause of maternal and perinatal mortality that requires advanced care and long hospital stays with uncertain outcomes for mother and baby. Care of eclamptic women is particularly challenging in low-income settings. Standards for medical care for eclampsia are established but the psychosocial needs of women are under-researched. AIM: To explore and describe women's experiences of having had, and recovered from, eclampsia at a tertiary hospital in Tanzania...
October 14, 2016: Women and Birth: Journal of the Australian College of Midwives
C K Hughes, M M Xie, S R McCoski, A D Ealy
Leptin is involved in various reproductive processes in humans and rodents, including placental development and function. The specific ways that leptin influences placental development and function in cattle are poorly understood. This work was completed to explore how leptin regulates hormone, cytokine and metalloprotease transcript abundance, and cell proliferation in cultured bovine trophoblast cells. In the first set of studies, cells were cultured in the presence of graded recombinant bovine leptin concentrations (0, 10, 50, 250 ng/mL) for 6 or 24 h...
September 13, 2016: Domestic Animal Endocrinology
Liga Blyholder, Elizabeth Chumanov, Kathleen Carr, Bryan Heiderscheit
BACKGROUND: With a recent increase in running popularity, more women choose to run during and after pregnancy. Little research has examined exercise behaviors and postpartum health conditions of runners. HYPOTHESIS: Antenatal and postpartum exercise is beneficial in reducing certain postpartum health conditions. STUDY DESIGN: Cross-sectional study. LEVEL OF EVIDENCE: Level 5. METHODS: A self-administered, online survey was developed that consisted of questions regarding antenatal and postpartum exercise behaviors, maternal history, and postpartum health conditions...
October 14, 2016: Sports Health
Sudipa Sarkar, Lindsay A Bischoff
Hyperthyroidism can occur during pregnancy and the postpartum period, and the treatment of hyperthyroidism should be considered in the preconception phase. Pregnancy has multiple normal physiologic effects on thyroid hormone, which is a separate process distinct from syndromes such as transient hyperthyroidism of hyperemesis gravidarum. The rationale regarding antithyroid drug use during different stages of pregnancy is reviewed, including the literature regarding adverse neonatal outcomes such as aplasia cutis and methimazole embryopathy in the setting of first trimester maternal methimazole use...
October 14, 2016: Seminars in Reproductive Medicine
Sara Moukarzel, Roger A Dyer, Bernd O Keller, Rajavel Elango, Sheila M Innis
BACKGROUND: Human milk contains unique glycerophospholipids, including ethanolamine-containing plasmalogens (Pls-PEs) in the milk fat globule membrane, which have been implicated in infant brain development. Brain Pls-PEs accumulate postnatally and are enriched in long-chain polyunsaturated fatty acids (LC-PUFAs), particularly docosahexaenoic acid (DHA). Fatty acid (FA) composition of Pls-PEs in milk is poorly understood because of the analytical challenges in separating Pls-PEs from other phospholipids in the predominating presence of triacylglycerols...
October 12, 2016: Journal of Nutrition
Jessica Pepe, Emmanuel Biver, Nicolas Bonnet, François R Herrmann, René Rizzoli, Thierry Chevalley, Serge Livio Ferrari
CONTEXT: The maternal heritability of bone microarchitecture according to the sex of the offspring is not known. OBJECTIVE: To explore gender difference and influence of mother menopausal status on the heritability of bone microarchitecture between mothers and their offspring. SUBJECTS AND METHODS: In 102 mother-daughter and 161 mother-son pairs, volumetric BMD and bone microarchitecture were measured at distal radius and tibia by high-resolution peripheral quantitative computed tomography (HR-pQCT)...
October 12, 2016: Journal of Clinical Endocrinology and Metabolism
Jorge Soliz, Rose Tam, Richard Kinkead
Perinatal exposure to adverse experiences disrupts brain development, including the brainstem network that regulates breathing. At adulthood, rats previously subjected to stress (in the form of neonatal maternal separation; NMS) display features reported in patients suffering from sleep disordered breathing, including an increased hypoxic ventilatory response and hypertension. This effect is also sex-specific (males only). Based on these observations, we hypothesized that NMS augments the carotid body's O2-chemosensitivity...
2016: Frontiers in Physiology
Janis Baird, Mary Barker, Nicholas C Harvey, Wendy Lawrence, Christina Vogel, Megan Jarman, Rufia Begum, Tannaze Tinati, Pamela Mahon, Sofia Strommer, Taylor Rose, Hazel Inskip, Cyrus Cooper
BACKGROUND: The nutritional status and health of mothers influence the growth and development of infants during pregnancy and postnatal life. Interventions that focus on improving the nutritional status and lifestyle of mothers have the potential to optimise the development of the fetus as well as improve the health of mothers themselves. Improving the diets of women of childbearing age is likely to require complex interventions that are delivered in a socially and culturally appropriate context...
October 12, 2016: Trials
Robert D Levitan, Pauline Jansen, Barbara Wendland, Henning Tiemeier, Vincent W Jaddoe, Patricia P Silveira, James L Kennedy, Leslie Atkinson, Alison Fleming, Marla Sokolowski, Helene Gaudreau, Meir Steiner, Laurette Dubé, Jill Hamilton, Ellen Moss, Ashley Wazana, Michael Meaney
BACKGROUND: Recent evidence suggests that early exposure to low maternal sensitivity is a risk factor for obesity in children and adolescents. A separate line of study shows that the seven-repeat (7R) allele of the dopamine-4 receptor gene (DRD4) increases susceptibility to environmental factors including maternal sensitivity. The current study integrates these lines of work by examining whether preschoolers carrying the 7R allele are more vulnerable to low maternal sensitivity as it relates to overweight/obesity risk...
October 11, 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
Natividade de Sá Couto-Pereira, Charles Francisco Ferreira, Carine Lampert, Danusa Mar Arcego, Ana Paula Toniazzo, Juliana Rombaldi Bernardi, Diego Carrilho da Silva, Eduardo Von Poser Toigo, Luisa Amalia Diehl, Rachel Krolow, Patrícia Pelufo Silveira, Carla Dalmaz
Neonatal handling (H) and maternal separation (MS) both induce changes in maternal care, but the contribution of these changes to the behavioral and neurochemical outcomes of the offspring remains unclear, as studies often find opposite results concerning the frequency of maternal behaviors, particularly in the MS paradigm. In this study, behavior displayed by H, MS and non-handled (NH) Wistar rat dams were observed during the first 10days after birth. A tentative assessment of the quality of maternal care was made, using a previously reported score that reflects behavior fragmentation and inconsistency...
October 4, 2016: International Journal of Developmental Neuroscience
Mohammad Charehsaz, Karin Sørig Hougaard, Hande Sipahi, Asiye Işın Doğan Ekici, Çiğdem Kaspar, Mustafa Culha, Ülkü Ündeğer Bucurgat, Ahmet Aydin
BACKGROUND: Evaluations of silver in both nanoparticle (Ag-NPs) and ionic forms indicate some adverse effects on living organisms, but little is known about their potential for developmental toxicity. In this study, developmental toxicity of Ag-NPs (from 0.2 to 20 mg/kg/day) and ionic Ag (AgNO3, 20 mg Ag/kg/day) were investigated in rats. METHODS: Animals were dosed by gavage from gestation day 7 - 20. The day after parturition, dams and pups were sacrificed and Ag level assessed in several maternal and pup organs...
October 6, 2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Mark R Hobbs, Susan Mb Morton, Polly Atatoa-Carr, Stephen R Ritchie, Mark G Thomas, Rajneeta Saraf, Carol Chelimo, Anthony Harnden, Carlos A Camargo, Cameron C Grant
AIM: Infectious disease (ID) hospitalisation rates are increasing in New Zealand (NZ), especially in pre-school children, and Māori and Pacific people. We aimed to identify risk factors for ID hospitalisation in infancy within a birth cohort of NZ children, and to identify differences in risk factors between ethnic groups. METHODS: We investigated an established cohort of 6846 NZ children, born in 2009-2010, with linkage to a national data set of hospitalisations...
October 7, 2016: Journal of Paediatrics and Child Health
Naixue Cui, Jianghong Liu
BACKGROUND: It has been well established that child physical abuse is a risk factor for cognitive deficits and behavioral problems. However, the possible link between cognitive deficits and behavioral problems placing children at a higher risk of physical abuse has been overlooked. Using a prospective design, the present study aims to examine whether previously measured cognition indicated by intelligence quotient (IQ), including performance IQ (PIQ) and verbal IQ (VIQ), and behavioral problems reported by multiple informants (i...
2016: Child and Adolescent Psychiatry and Mental Health
Ingrid Nylander, Aniruddha Todkar, Linnea Granholm, Maria Vrettou, Megha Bendre, Wout Boon, Henrik Andershed, Catherine Tuvblad, Kent W Nilsson, Erika Comasco
Alcohol misuse has been linked to dysregulation of stress, emotion, and reward brain circuitries. A candidate key mediator of this association is the FK506-binding protein (FKBP5), a negative regulator of the glucocorticoid receptor. The aim of the present study was to further understand the Fkbp5/FKBP5-related genetic underpinnings underlying the relationship between early life social relations and alcohol drinking. The effect of maternal separation and voluntary alcohol drinking on Fkbp5 expression was investigated in the brain of young adult rats, whereas the interaction effect of the functional FKBP5 single nucleotide polymorphism rs1360780 genotype and parent-child relationship on problematic drinking was examined in young adult humans...
October 5, 2016: Molecular Neurobiology
W Teng, H Chen, F Guo, X Du, X Fu, Y Fang, H Zhang, M Fang, M Ding
Neurokinin-1 receptor (NK1R) is a high affinity Substance P (SP) receptor and plays a key role in visceral hypersensitivity in irritable bowel syndrome (IBS). Early life stress is a significant risk factor in IBS. The aim of the present study was to investigate the influence of neonatal maternal separation on the expression and distribution of SP and its receptor along the brain-gut axis in a neonatal maternally separated rat model with visceral hypersensitivity. Male neonatal Sprague-Dawley rats, 2-21-day old, were randomly distributed into maternal separation groups of 3 h daily maternal separation (MS) or non-handling (NH)...
August 30, 2016: Genetics and Molecular Research: GMR
C R Villa, J Chen, B Wen, S M Sacco, A Taibi, W E Ward, E M Comelli
BACKGROUND/OBJECTIVES: Vitamin D is an anti-inflammatory nutrient and a determinant of bone health. Some prospective studies suggest that maternal vitamin D status is positively associated with offspring bone mass. We found that serum concentrations of lipopolysaccharide (LPS), an inflammatory molecule related to adiposity, insulin resistance and bone resorption, is lower in healthy mouse offspring exposed to high dietary vitamin D during pregnancy and lactation. LPS reaches the circulation via the gut...
October 4, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Rikke Thaarup Wesselhöft
Major depressive disorder (MDD) is a frequent and painful mental disorder considered among the five leading causes of disability in Western countries by the World Health Organization. MDD occurs at all ages, but childhood onset MDD has a more severe course with longer depressive episodes, more suicidality, and more frequent hospitalization, than later onset MDD. Childhood seems to be a window of opportunity for prevention of mental disorders, and subsequently prevention of MDD onset in childhood is recommended...
October 2016: Danish Medical Journal
Jaak Panksepp
During the past half century of research with preclinical animal models, affective neuroscience has helped identify and illuminate the functional neuroanatomies and neurochemistries of seven primary process, i.e., genetically provided emotional systems of mammalian brains. All are subcortically localized, allowing animal models to guide the needed behavioral and neuroscientific analyses at levels of detail that cannot be achieved through human research, including modern brain imaging. They consist of the following neuronal processes: SEEKING/Enthusiasm, RAGE/Anger, FEAR/Anxiety, sexual LUST/Passion, maternal CARE/Nurturance, separation-distress PANIC/Grief and PLAY/Social Joy...
October 2, 2016: Current Topics in Behavioral Neurosciences
Yoav Litvin, Cortney A Turner, Mariel B Rios, Pamela M Maras, Sraboni Chaudhury, Miriam R Baker, Peter Blandino, Stanley J Watson, Huda Akil, Bruce McEwen
We aimed to determine the short-term effects of early-life stress in the form of maternal separation (MS) on anxiety-like behavior in male rat pups. In order to assess anxiety, we measured 40kHz separation-induced ultrasonic vocalizations (USV) on postnatal day (PND) 11. We further aimed to evaluate the potential involvement of two neurochemical systems known to regulate social and anxiety-like behaviors throughout life: oxytocin (OT) and fibroblast growth factor 2 (FGF2). For these purposes, we tested the effects of neonatal administration (on PND1) of an acute dose of FGF2 on USV and its potential interaction with MS...
September 28, 2016: Hormones and Behavior
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"