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https://www.readbyqxmd.com/read/29332092/early-life-stress-activates-glial-cells-in-the-hippocampus-but-attenuates-cytokine-secretion-in-response-to-an-immune-challenge-in-rat-pups
#1
Luis Miguel Saavedra, Bertha Fenton Navarro, Luz Torner
OBJECTIVE: Early life stress (ELS) increases the vulnerability to developing psychopathological disorders in adulthood that are accompanied by brain inflammatory processes. However, it is not known how a combined double hit (stress and immune) at an early age affects the response of the neuroimmune system. Here we investigated the effect of periodic maternal separation (MS) followed by administration of lipopolysaccharide (LPS) on glial cells in the CA3 region and hilus of the hippocampus and on cytokine release on postnatal day (PN) 15...
January 13, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29328035/assessment-of-neurodevelopmental-outcomes-in-infants-6-12-months-of-age-according-to-impact-of-perinatal-risk-factors
#2
N Tskimanauri, N Khachapuridze, P Imnadze, T Chanadiri, S Bakhtadze
The purpose of this research was to investigate the developmental follow-up of infants (at age of 6 month and 12 month), exposed to separate and combination impact of perinatal risk factors, compared with not exposed cases, within the prospective cohort study. Between January 2015 and January 2017, in this research we prospectively enrolled 1018 live-born infants from the medical reports of the participating clinics in Tbilisi (capital of Republic of Georgia) and Mtskheta, Dusheti (districts of Georgia). Within postnatal follow-up, the children from whole population were assessed at 6 and 12 months of age by family doctors using the Denver Developmental Screening Test (Denver II)...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29326182/variations-in-childbirth-interventions-in-high-income-countries-protocol-for-a-multinational-cross-sectional-study
#3
Anna Seijmonsbergen-Schermers, Ank de Jonge, Thomas van den Akker, Katrien Beeckman, Annick Bogaerts, Monalisa Barros, Patricia Janssen, Lorena Binfa, Eva Rydahl, Lucy Frith, Mechthild Gross, Berglind Hálfdánsdóttir, Deirdre Daly, Jean Calleja-Agius, Patricia Gillen, Anne Britt Vika Nilsen, Eugene Declercq
INTRODUCTION: There are growing concerns about the increase in rates of commonly used childbirth interventions. When indicated, childbirth interventions are crucial for preventing maternal and perinatal morbidity and mortality, but their routine use in healthy women and children leads to avoidable maternal and neonatal harm. Establishing ideal rates of interventions can be challenging. This study aims to describe the range of variations in the use of commonly used childbirth interventions in high-income countries around the world, and in outcomes in nulliparous and multiparous women...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29325572/modeling-the-relationship-between-women-s-perceptions-and-future-intention-to-use-institutional-maternity-care-in-the-western-highlands-of-guatemala
#4
Emily Peca, John Sandberg
BACKGROUND: Despite global gains, women in hard-to-reach areas are at a relatively higher risk of death and disability related to childbirth. Traditional methods of measuring satisfaction may mask negative experiences (such as disrespect and abuse) that can drive down demand for institutional care. Better measurement of women's perceptions of care quality, especially among marginalized populations with historically low utilization of institutional care, are needed to inform how to improve services and foster greater utilization of (potentially life-saving) clinical care...
January 11, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29325428/mother-child-coregulation-of-parasympathetic-processes-differs-by-child-maltreatment-severity-and-subtype
#5
Erika Lunkenheimer, Alex Busuito, Kayla M Brown, Elizabeth A Skowron
Parasympathetic processes appear to underlie maladaptive parent-child interactions in maltreating families, but it is unknown whether parent-child coregulation of respiratory sinus arrhythmia (RSA) differs by child maltreatment severity and subtype. RSA coregulation in maltreating and nonmaltreating mother-child dyads ( N = 146; age 3-5 years) during two dyadic tasks was analyzed using dynamic time series modeling. Nonmaltreating dyads showed positive RSA concordance but maltreating dyads (when examined as one group) did not...
January 1, 2018: Child Maltreatment
https://www.readbyqxmd.com/read/29310603/characteristics-of-positive-interaction-parenting-style-among-primiparous-teenage-optimal-age-and-advanced-age-mothers-in-canada
#6
Theresa H M Kim, Jennifer A Connolly, Michael Rotondi, Hala Tamim
BACKGROUND: Positive-interaction parenting early in childhood is encouraged due to its association with behavioural development later in life. The objective of this study was to examine if the level of positive-interaction parenting style differs among teen, optimal age, and advanced age mothers in Canada, and to identify the characteristics associated with positive-interaction parenting style separately for each age group. METHODS: This was a cross-sectional secondary analysis of the National Longitudinal Survey of Children and Youth...
January 8, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29302748/like-mother-like-daughter-like-father-like-son-intergenerational-transmission-of-internalizing-symptoms-at-early-school-age-a-longitudinal-study
#7
Anna Andreas, Lars O White, Susan Sierau, Sonja Perren, Kai von Klitzing, Annette M Klein
Despite the well-established link between parental depressive symptoms and children's internalizing symptoms, studies that divide transmission into gender-specific components remain scarce. Therefore, the present study focused on gender-specific associations between internalizing symptoms of parents and children over the course of early school age, a key stage where gender-specific roles are increasingly adopted. Participants were 272 children (49.6% girls) oversampled for internalizing symptoms. Parents completed questionnaires twice during early school age (mean age time 1 = 7...
January 4, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29302206/maternal-separation-does-not-produce-a-significant-behavioral-change-in-mice
#8
Shawn Tan, Hin San Ho, Anna Yoonsu Song, Joey Low, Hyunsoo Shawn Je
Early life adversities together with genetic predispositions have been associated with elevated risks of neuropsychiatric disorders during later life. In order to investigate the underlying mechanisms, many chronic, early-life stress paradigms in multiple animal models have been developed. Previously, studies reported that maternal separation (MS) in the early postnatal stages triggers depression-and/or anxiety-like behaviors in rats. However, similar studies using mice have reported inconsistent behavioral outcomes...
December 2017: Experimental Neurobiology
https://www.readbyqxmd.com/read/29301333/experimental-models-of-irritable-bowel-syndrome-and-the-role-of-the-enteric-neurotransmission
#9
REVIEW
Maria Giuliana Vannucchi, Stefano Evangelista
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal diseases in humans. It is characterized by visceral pain and/or discomfort, hypersensitivity and abnormal motor responses along with change in gut habits. Although the etio-pathogenesis of IBS is only partially understood, a main role has been attributed to psychosocial stress of different origin. Animal models such as neonatal maternal separation, water avoidance stress and wrap restraint stress have been developed as psychosocial stressors in the attempt to reproduce the IBS symptomatology and identify the cellular mechanisms responsible for the disease...
January 3, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29300195/expressing-human-milk-in-the-nicu-coping-mechanisms-and-challenges-shape-the-complex-experience-of-closeness-and-separation
#10
Maude Bujold, Nancy Feeley, Anna Axelin, Claudia Cinquino
BACKGROUND: Human milk has multiple benefits for human health; however, rates of infants receiving human milk at discharge in Canadian neonatal intensive care units (NICUs) are far below recommendations of the Baby Friendly Hospital Initiative supported by the Canadian Pediatric Association. Mothers of infants requiring NICU care usually need to express their milk, especially mothers of premature infants, since for some time their infant is unable to feed directly at the breast. Expressing human milk for an extended period can be challenging for mothers...
January 3, 2018: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/29298662/influence-of-weight-gain-according-to-institute-of-medicine-2009-recommendation-on-spontaneous-preterm-delivery-in-twin-pregnancies
#11
Paola Algeri, Francesca Pelizzoni, Davide Paolo Bernasconi, Francesca Russo, Maddalena Incerti, Sabrina Cozzolino, Salvatore Andrea Mastrolia, Patrizia Vergani
BACKGROUNDS: Maternal total weight gain during pregnancy influences adverse obstetric outcomes in singleton pregnancies. However, its impact in twin gestation is less understood. Our objective was to estimate the influence of total maternal weight gain on preterm delivery in twin pregnancies. METHODS: We conducted a retrospective cohort study including diamniotic twin pregnancies with spontaneous labor delivered at 28 + 0 weeks or later. We analyzed the influence of total weight gain according to Institute of Medicine (IOM) cut-offs on the development of preterm delivery (both less than 34 and 37 weeks)...
January 3, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29298162/prenatal-maternal-serum-concentrations-of-per-and-polyfluoroalkyl-substances-in-association-with-autism-spectrum-disorder-and-intellectual-disability
#12
Kristen Lyall, Vincent M Yau, Robin Hansen, Martin Kharrazi, Cathleen K Yoshida, Antonia M Calafat, Gayle Windham, Lisa A Croen
BACKGROUND: Emerging work has examined neurodevelopmental outcomes following prenatal exposure to per- and polyfluoroalkyl substances (PFAS), but few studies have assessed associations with autism spectrum disorder (ASD). OBJECTIVES: Our objective was to estimate associations of maternal prenatal PFAS concentrations with ASD and intellectual disability (ID) in children. METHODS: Participants were from a population-based nested case-control study of children born from 2000 to 2003 in southern California, including children diagnosed with ASD (n=553), ID without autism (n=189), and general population (GP) controls (n=433)...
January 2, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29291495/prenatal-and-early-postnatal-stress-and-later-life-inflammation
#13
Jolene Masters Pedersen, Erik Lykke Mortensen, Dinne Skjærlund Christensen, Maarten Rozing, Helle Brunsgaard, Rikke Hodal Meincke, Gitte Lindved Petersen, Rikke Lund
BACKGROUND: Evidence suggests that maternal psychological and social stress during the prenatal period and in childhood represent an important condition that may adversely impact the anatomy and physiology of the developing child with implications for a number of health-related conditions and disorders. In a large prospective study, we aim to address if social stressors in the prenatal and early postnatal periods, as individual exposures as well as their accumulation, are associated with a range of inflammatory markers in late middle-aged offspring...
December 21, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29288748/abandoned-prairie-vole-mothers-show-normal-maternal-care-but-altered-emotionality-potential-influence-of-the-brain-corticotropin-releasing-factor-system
#14
Oliver J Bosch, Tobias T Pohl, Inga D Neumann, Larry J Young
When fathers leave the family, mothers are at increased risk of developing depression and anxiety disorders. In biparental, socially monogamous prairie voles (Microtus ochrogaster), sudden bond disruption increases passive stress-coping, indicative of depressive-like behavior, and acts as chronic stressor in both males and females. However, the consequences of separation in lactating prairie vole mothers are unknown. In the present study, following 18 days of cohousing, half of the prairie vole pairs were separated by removing the male...
December 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29288745/a-translational-approach-to-the-genetics-of-anxiety-disorders
#15
N W McGregor, J J Dimatelis, P J Van Zyl, S M J Hemmings, C Kinnear, V A Russell, D J Stein, C Lochner
There have been important advances in our understanding of the genetic architecture of anxiety disorders. At the same time, relatively few genes have reached genome wide significance in anxiety disorders, and there is relatively little work on how exposure to an adverse environment impacts on gene expression in either animal models or human clinical populations. Here we assessed differential expression of genes of the dorsal striatum involved in synaptic transmission in an animal models of early adversity (maternal separation followed by restraint stress), and investigated whether variants in these genes were associated with risk for anxiety disorders, particularly in the presence of environmental stressors...
December 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29286418/using-fluorescence-in-situ-hybridization-fish-to-monitor-the-state-of-arm-cohesion-in-prometaphase-and-metaphase-i-drosophila-oocytes
#16
Adrienne T Perkins, Sharon E Bickel
In humans, chromosome segregation errors in oocytes are responsible for the majority of miscarriages and birth defects. Moreover, as women age, their risk of conceiving an aneuploid fetus increases dramatically and this phenomenon is known as the maternal age effect. One requirement for accurate chromosome segregation during the meiotic divisions is maintenance of sister chromatid cohesion during the extended prophase period that oocytes experience. Cytological evidence in both humans and model organisms suggests that meiotic cohesion deteriorates during the aging process...
December 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29281747/understanding-the-connection-between-attachment-trauma-and-maternal-self-efficacy-in-depressed-mothers
#17
Natalie Brazeau, Samantha Reisz, Deborah Jacobvitz, Carol George
Maternal self-efficacy predicts sensitive and responsive caregiving. Low maternal self-efficacy is associated with a higher incidence of postpartum depression. Maternal self-efficacy and postpartum depression can both be buffered by social support. Maternal self-efficacy and postpartum depression have both been linked independently, albeit in separate studies, to the experience of violent trauma, childhood maltreatment, and spousal abuse. This study proposed a model in which postpartum depression mediates the relation between attachment trauma and maternal self-efficacy, with emotional support as a moderator...
December 27, 2017: Infant Mental Health Journal
https://www.readbyqxmd.com/read/29276736/maternal-separation-stress-leads-to-resilience-against-neuropathic-pain-in-adulthood
#18
Julien Genty, Milène Tetsi Nomigni, Fernand Anton, Ulrike Hanesch
Early life stress (ELS) leads to a permanent reprogramming of biochemical stress response cascades that may also be relevant for the processing of chronic pain states such as neuropathy. Despite clinical evidence, little is known about ELS-related vulnerability for neuropathic pain and the possibly underlying etiology. In the framework of experimental studies aimed at investigating the respective relationships we used the established ELS model of maternal separation (MS). Rat dams and neonates were separated for 3 h/day from post-natal day 2-12...
February 2018: Neurobiology of Stress
https://www.readbyqxmd.com/read/29275445/issues-on-the-diagnosis-and-etiopathogenesis-of-mood-disorders-reconsidering-dsm-5
#19
REVIEW
Kazuyoshi Ogasawara, Yukako Nakamura, Hiroyuki Kimura, Branko Aleksic, Norio Ozaki
The authors present a narrative review from the diagnostic and nosologic viewpoints of mood disorders (bipolar and depressive ones) by revisiting the revision from the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders, Text Revision to DSM-5, including the following: the separation of the bipolar and depressive sections; the addition of increased energy and continuation of symptoms to the hypo/manic criteria; the elimination of mixed episodes; the creation of new categories and specifiers ("other specified bipolar and related disorder", "disruptive mood dysregulation disorder", "with anxious distress", "with mixed features", "with peripartum onset"); the categorization of hypo/manic episodes during antidepressant treatment into bipolar disorder; the elimination of the "bereavement exclusion"; the ambiguous separation between bipolar I and II; the insufficient distinction between "other specified bipolar and related disorders" and major depressive disorder; the differentiation regarding borderline personality disorder; agitation; premenstrual dysphoric disorder; and society and psychiatry...
December 23, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29261691/do-experiences-and-perceptions-about-quality-of-care-differ-among-social-groups-in-nepal-a-study-of-maternal-healthcare-experiences-of-women-with-and-without-disabilities-and-dalit-and-non-dalit-women
#20
Hridaya Raj Devkota, Andrew Clarke, Emily Murray, Nora Groce
BACKGROUND: Suboptimal quality of care and disparities in services by healthcare providers are often reported in Nepal. Experience and perceptions about quality of care may differ according to women's socio-cultural background, individual characteristics, their exposure and expectations. This study aimed to compare perceptions of the quality of maternal healthcare services between two groups that are consistently considered vulnerable, women with disabilities from both the non-Dalit population and Dalit population and their peers without disabilities from both non-Dalit and Dalit communities...
2017: PloS One
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