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https://www.readbyqxmd.com/read/28945013/pro-regenerative-hydrogel-restores-scarless-skin-during-cutaneous-wound-healing
#1
Guoming Sun
The transformation of fibrotic healing process to regenerative one has great potential to fully restore wounded skin. The M2 macrophage phenotype promotes constructive tissue remodeling and instructs tissue repair in a regenerative manner. It is hypothesized that hydrogels that can establish robustness of endogenous cells to regulate M2 phenotype will promote constructive dermal remodeling. Toward this end, a series of dextran-based bioabsorbable hydrogels are developed and self-crosslinkable dextran-isocyanatoethyl methacrylate-ethylamine (DexIEME) is identified as the potential scaffold...
September 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28944921/inhibition-of-microrna%C3%A2-155-ameliorates-cardiac-fibrosis-in-the-process-of-angiotensin-ii%C3%A2-induced-cardiac-remodeling
#2
Yuzhen Wei, Xiaofei Yan, Lianhua Yan, Fen Hu, Wenhan Ma, Ya Wang, Shuai Lu, Qiutang Zeng, Zhaohui Wang
Cardiac fibrosis triggered by pressure overload represents one of the major challenges in the treatment of cardiovascular diseases. MicroRNA (miRNA/miR)‑155, a member of the small RNA family, has previously been demonstrated to be associated with cardiac inflammation. However, the effect of miR‑155 on cardiac fibrosis induced by angiotensin II (Ang II), particularly in cardiac fibroblasts, requires further investigation. The present study aimed to investigate the effect of miR‑155 in Ang II‑induced cardiac fibrosis using animal models and cardiac fibroblasts...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944892/-retracted-cathepsin-b-inhibition-attenuates-cardiac-dysfunction-and-remodeling-following-myocardial-infarction-by-inhibiting-the-nlrp3-pathway
#3
Aiguo Liu, Xuan Gao, Qingbin Zhang, Lianqun Cui
An interested reader drew to our attention the fact that Figs. 4 and 5 in the above-mentioned article had already been published as Figs. 4 and  5 in the following paper [Boyle AJ, Kelly DJ, Zhang Y, Cox AJ, Gow RM, Way K, Itescu S, Krum H and Gilbert RE: Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction. J Mol Cell Cardiol 39: 213-221, 2005]. Following an investigation, the Journal was able to confirm that this accusation of plagiarism is well-founded...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944862/ing2-a-tumor-associated-gene-enhances-pai%C3%A2-1-and-hspa1a-expression-with-hdac1-and-msin3a-through-the-phd-domain-and-c%C3%A2-terminal
#4
Chiyo Ohkouchi, Kensuke Kumamoto, Motonobu Saito, Teruhide Ishigame, Shin-Ichi Suzuki, Seiichi Takenoshita, Cutis C Harris
Inhibitor of growth 2 (ING2) is involved in chromatin remodeling and it has previously been suggested that ING2 may regulate gene expression. The authors previously identified matrix metalloproteinase 13 (MMP13) as a target gene of ING2 in colorectal cancer. The aim of the present study was to identify novel genes regulated by ING2 and histone deacetylase 1 (HDAC1) and to clarify the biological significance of the ING2 structure. The present study generated the point mutant constructs of ING2 and deletion constructs consisting of partial ING2 to investigate the effect on gene expression and verify the interaction with HDAC1, mSin3A and sap30...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944821/transplantation-of-periodontal-ligament-cell-sheets-expressing-human-%C3%AE-%C3%A2-defensin%C3%A2-3-promotes-anti%C3%A2-inflammation-in-a-canine-model-of-periodontitis
#5
Minwen Zhu, Bo Miao, Jianhua Zhu, Haiyan Wang, Zengtong Zhou
Periodontitis is a chronic oral inflammatory disease caused by microorganisms. Human β‑defensin‑3 (HBD‑3) is an endogenous antimicrobial peptide that inhibits a broad spectrum of microorganisms. Cell sheet technology has been widely applied in tissue and organ reconstructions. In the current study, it was aimed to investigate the anti‑inflammatory effect of periodontal tissue engineered by HBD‑3 gene‑modified periodontal ligament cell (PDLC) sheets, and to identify a suitable method of promoting the regeneration of periodontal tissues...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944671/prioritizing-popular-proteins-in-liver-cancer-remodelling-one-carbon-metabolism
#6
María Isabel Mora, Manuela Molina, Leticia Odriozola, Felix Elortza, Jose M Mato, Barbara Sitek, Pumin Zhang, Fuchu He, Maria Uxue Latasa, Matías Avila, Fernando Corrales
Primary liver cancer (HCC) is recognized as the fifth most common neoplasm and the second leading cause of cancer deaths worldwide. Most risk factors are known and the molecular pathogenesis has been widely studied in the last decade; however, the underlying molecular mechanisms remain to be unveiled, as they will facilitate definition of novel biomarkers and clinical targets for more effective patient management. In this study, we utilize the B/D-HPP popular protein strategy. We report a list of popular proteins that have been highly co-cited with the expression "liver cancer"...
September 25, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28944359/crestal-sinus-lift-using-an-implant-with-an-internal-l-shaped-channel-1-year-after-loading-results-from-a-prospective-cohort-study
#7
Marco Tallarico, David L Cochran, Erta Xhanari, Claudia Dellavia, Elena Canciani, Eitan Mijiritsky, Silvio Mario Meloni
PURPOSE: To evaluate the clinical and radiographic outcomes of a one-stage crestal sinus elevation procedure using a self-tapping endosseous implant system (iRaise, Maxillent, Herzliya, Israel) developed for sinus augmentation, 1 year after loading. MATERIALS AND METHODS: Patients needing restoration in the posterior maxilla with a residual alveolar crest of 3 to 8 mm in height and 5 mm in width distal to the canine as measured on CBCT scan were treated using the iRaise sinus lift system...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28944344/irf4-couples-anabolic-metabolism-to-th1-cell-fate-determination
#8
Radomir Kratchmarov, Simone A Nish, Wen-Hsuan W Lin, William C Adams, Yen-Hua Chen, Bonnie Yen, Nyanza J Rothman, Ulf Klein, Steven L Reiner
Anabolic metabolism in lymphocytes promotes plasmablast and cytotoxic T cell differentiation at the expense of self-renewal. Heightened expression and function of the transcription factor IFN regulatory factor 4 (IRF4) accompany enhanced anabolic induction and full commitment to functional differentiation in B cells and CD8(+) T cells. In this study, we used a genetic approach to determine whether IRF4 plays an analogous role in Th1 cell induction. Our findings indicate that IRF4 promotes determined Th1 cell differentiation in tandem with anabolic metabolism of CD4(+) T cells...
September 1, 2017: Immunohorizons
https://www.readbyqxmd.com/read/28944227/neonatal-enterovirus-myocarditis-with-severe-dystrophic-calcification-novel-treatment-with-pocapavir
#9
Samuel G Wittekind, Catherine C Allen, John L Jefferies, Mantosh S Rattan, Peace C Madueme, BreAnn N Taylor, Ryan A Moore
Dystrophic myocardial calcification occurs in the setting of myocardial injury and normal serum calcium. We present a case of a neonate with prominent dystrophic calcification and severe left ventricular systolic dysfunction in the setting of enterovirus myocarditis. These findings are superbly illustrated by multiple imaging modalities. The patient was treated with the novel antiviral, pocapavir, in addition to a standard heart failure regimen. The dystrophic calcification persisted but the left ventricle remodeled significantly...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28943640/exercise-dependent-regulation-of-the-tumour-microenvironment
#10
REVIEW
Graeme J Koelwyn, Daniela F Quail, Xiang Zhang, Richard M White, Lee W Jones
The integrity and composition of the tumour microenvironment (TME) is highly plastic, undergoing constant remodelling in response to instructive signals derived from alterations in the availability and nature of systemic host factors. This 'systemic milieu' is directly modulated by host exposure to modifiable lifestyle factors such as exercise. Host exposure to regular exercise markedly reduces the risk of the primary development of several cancers and might improve clinical outcomes following a diagnosis of a primary disease...
September 25, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28943533/incidence-and-significance-of-spontaneous-st-segment-re-elevation-after-reperfused-anterior-acute-myocardial-infarction%C3%A3-relationship-with-infarct-size-adverse-remodeling-and-events-at-1-year
#11
Léo Cuenin, Sophie Lamoureux, Mathieu Schaaf, Thomas Bochaton, Jean-Pierre Monassier, Marc J Claeys, Gilles Rioufol, Gérard Finet, David Garcia-Dorado, Denis Angoulvant, Meyer Elbaz, Nicolas Delarche, Pierre Coste, Marc Metge, Thibault Perret, Pascal Motreff, Eric Bonnefoy-Cudraz, Gérald Vanzetto, Olivier Morel, Inesse Boussaha, Michel Ovize, Nathan Mewton
BACKGROUND: Up to 25% of patients with ST elevation myocardial infarction (STEMI) have ST segment re-elevation after initial regression post-reperfusion and there are few data regarding its prognostic significance.Methods and Results:A standard 12-lead electrocardiogram (ECG) was recorded in 662 patients with anterior STEMI referred for primary percutaneous coronary intervention (PPCI). ECGs were recorded 60-90 min after PPCI and at discharge. ST segment re-elevation was defined as a ≥0...
September 23, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28943493/the-european-collaborative-project-on-inflammation-and-vascular-wall-remodeling-in-atherosclerosis-intravascular-ultrasound-atheroremo-ivus-study
#12
Sanneke P M de Boer, Yael Baran, Hector M Garcia-Garcia, Itamar Eskin, Mattie Lenzen, Marcus E Kleber, Evelyn Regar, Peter J de Jaegere, Jurgen M Ligthart, Robert Jan van Geuns, Tehro Lehtimäki, Reijo Laaksonen, Eric Boersma, Winfried März, Erin Halperin, Patrick W Serruys, Wolfgang Koenig
AIMS: The European Collaborative Project on Inflammation and Vascular Wall Remodelling in Atherosclerosis - Intravascular Ultrasound (ATHEROREMO-IVUS) study has been designed as an exploratory clinical study to investigate the associations between genetic variation, coronary atherosclerosis phenotypes, and plaque vulnerability as determined by IVUS. METHODS AND RESULTS: The ATHEROREMO-IVUS study is a prospective, observational study of 581 patients with stable angina pectoris or acute coronary syndrome (ACS) who were referred for coronary angiography to the Thoraxcenter, Rotterdam, enriched with 265 IBIS-2 participants (total population, n=846)...
September 26, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28943314/the-chd1-chromatin-remodeler-shifts-nucleosomal-dna-bidirectionally-as-a-monomer
#13
Yupeng Qiu, Robert F Levendosky, Srinivas Chakravarthy, Ashok Patel, Gregory D Bowman, Sua Myong
Chromatin remodelers catalyze dynamic packaging of the genome by carrying out nucleosome assembly/disassembly, histone exchange, and nucleosome repositioning. Remodeling results in evenly spaced nucleosomes, which requires probing both sides of the nucleosome, yet the way remodelers organize sliding activity to achieve this task is not understood. Here, we show that the monomeric Chd1 remodeler shifts DNA back and forth by dynamically alternating between different segments of the nucleosome. During sliding, Chd1 generates unstable remodeling intermediates that spontaneously relax to a pre-remodeled position...
September 20, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28942966/haploinsufficiency-of-the-chromatin-remodeler-bptf-causes-syndromic-developmental-and-speech-delay-postnatal-microcephaly-and-dysmorphic-features
#14
Paweł Stankiewicz, Tahir N Khan, Przemyslaw Szafranski, Leah Slattery, Haley Streff, Francesco Vetrini, Jonathan A Bernstein, Chester W Brown, Jill A Rosenfeld, Surya Rednam, Sarah Scollon, Katie L Bergstrom, Donald W Parsons, Sharon E Plon, Marta W Vieira, Caio R D C Quaio, Wagner A R Baratela, Johanna C Acosta Guio, Ruth Armstrong, Sarju G Mehta, Patrick Rump, Rolph Pfundt, Raymond Lewandowski, Erica M Fernandes, Deepali N Shinde, Sha Tang, Juliane Hoyer, Christiane Zweier, André Reis, Carlos A Bacino, Rui Xiao, Amy M Breman, Janice L Smith, Nicholas Katsanis, Bret Bostwick, Bernt Popp, Erica E Davis, Yaping Yang
Bromodomain PHD finger transcription factor (BPTF) is the largest subunit of nucleosome remodeling factor (NURF), a member of the ISWI chromatin-remodeling complex. However, the clinical consequences of disruption of this complex remain largely uncharacterized. BPTF is required for anterior-posterior axis formation of the mouse embryo and was shown to promote posterior neuroectodermal fate by enhancing Smad2-activated wnt8 expression in zebrafish. Here, we report eight loss-of-function and two missense variants (eight de novo and two of unknown origin) in BPTF on 17q24...
September 19, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28942576/how-i-do-it-3d-endoscopic-treatment-of-metopic-craniosynostosis-through-a-single-incision
#15
Juan Delgado-Fernández, Mónica Rivero-Garvía, Javier Márquez-Rivas
BACKGROUND: Endoscopic approaches for craniosynostosis are a growing field in pediatric neurosurgery. In metopic synostosis, previous reports for complete fronto-orbital remodeling have proposed an intervention with multiple incisions (bregmatic, tarsal, and preauricular) to open frontonasal and frontoethmoidal synostotic sutures, and orbital roof. METHODS: We propose a technique to complete all these osteotomies with a unique incision anterior to the bregmatic fontanel under 3D endoscopic vision, and review possible complications, limits, and pitfalls...
September 24, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28942458/diabetic-retinopathy-hyperglycaemia-oxidative-stress-and-beyond
#16
REVIEW
Hans-Peter Hammes
Diabetic retinopathy remains a relevant clinical problem. In parallel with diagnostic and therapeutic improvements, the role of glycaemia and reactive metabolites causing cell stress and biochemical abnormalities as treatment targets needs continuous re-evaluation. Furthermore, the basic mechanisms of physiological angiogenesis, remodelling and pruning give important clues about the origins of vasoregression during the very early stages of diabetic retinopathy and can be modelled in animals. This review summarises evidence supporting a role for the neurovascular unit-composed of neuronal, glial and vascular cells-as a responder to the biochemical changes imposed by reactive metabolites and high glucose...
September 24, 2017: Diabetologia
https://www.readbyqxmd.com/read/28942269/echocardiographic-strain-analysis-for-the-early-detection-of-myocardial-structural-abnormality-and-initiation-of-drug-therapy-in-a-mouse-model-of-dilated-cardiomyopathy
#17
Minjuan Zheng, Feng Pan, Ying Liu, Zhenzhou Li, Xiaodong Zhou, Xin Meng, Liwen Liu, Shuping Ge
This study aimed to evaluate the role of echocardiography-based strain analysis in the early diagnosis and guidance for management of dilated cardiomyopathy (DCM). Muscular dystrophy mice (which spontaneously develop DCM) and control (C57 BL/6 J) mice were sequentially evaluated by ultrasound biomicroscopy, conventional left ventricle (LV) measurement, two-dimensional (2-D) strain analysis and myocardial histologic analysis for 12 consecutive months. Significant alternation of LV remodeling and dysfunction could be detected by conventional echocardiography after 9 mo, by strain analysis after 5 mo and by histologic analysis after 4 mo...
September 20, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28942147/arabidopsis-pecp1-and-ps2-are-phosphate-starvation-inducible-phosphocholine-phosphatases
#18
Artik Elisa Angkawijaya, Yuki Nakamura
Phosphate-starved plants reduce phosphatidylcholine content presumably to provide an internal phosphate source while replacing membrane phospholipids by galactolipids, a process termed membrane lipid remodeling. However, whether the metabolic fate of released phosphocholine is a phosphate source remains elusive because primary phosphocholine phosphatases in vivo are unknown in seed plants. Here, we show that PECP1 and PS2 are the primary phosphocholine phosphatases in Arabidopsis and function redundantly under phosphate starvation...
September 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28942102/skov3-cells-containing-a-truncated-arid1a-protein-have-a-restricted-genome-wide-response-to-glucocorticoids
#19
F E Stubbs, M T Birnie, S C Biddie, S L Lightman, B L Conway-Campbell
AT-rich interacting domain subunit 1a (ARID1a) is an essential SWI/SNF component frequently mutated in human cancers. ARID1a mutations have also been associated with glucocorticoid resistance, potentially related to the well-established role of the SWI/SNF complex in glucocorticoid target gene regulation. Glucocorticoids are steroid hormones important for regulating many physiological processes through the activation of the glucocorticoid receptor (GR). As GR interacts directly with ARID1a, we hypothesized that a truncating ARID mutation would interfere with GR-dependent gene regulation...
September 20, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28941985/stimulation-of-ganglionated-plexus-attenuates-cardiac-neural-remodeling-and-heart-failure-progression-in-a-canine-model-of-acute-heart-failure-post-myocardial-infarction
#20
Da Luo, Huihui Hu, Zhiliang Qin, Shan Liu, Xiaomei Yu, Ruisong Ma, Wenbo He, Jing Xie, Zhibing Lu, Bo He, Hong Jiang
BACKGROUND: Heart failure (HF) is associated with autonomic dysfunction. Vagus nerve stimulation has been shown to improve cardiac function both in HF patients and animal models of HF. The purpose of this present study is to investigate the effects of ganglionated plexus stimulation (GPS) on HF progression and autonomic remodeling in a canine model of acute HF post-myocardial infarction. METHODS AND RESULTS: Eighteen adult mongrel male dogs were randomized into the control (n=8) and GPS (n=10) groups...
September 18, 2017: Autonomic Neuroscience: Basic & Clinical
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