keyword
https://read.qxmd.com/read/38493442/impact-of-a-quality-improvement-initiative-and-monthly-multidisciplinary-meetings-on-outcomes-after-posterior-spinal-fusion-for-adolescent-idiopathic-scoliosis
#1
JOURNAL ARTICLE
Astrid C Hengartner, Aladine A Elsamadicy, Anshu Jonnalagadda, Samuel Craft, Josiah J Z Sherman, Benjamin C Reeves, Tiana Fernandez, Joshua Hobbs, Andrew B Koo, Michael DiLuna, Dominick A Tuason
INTRODUCTION: Several studies have demonstrated the benefits of enhanced recovery after surgery (ERAS) protocols for patients with adolescent idiopathic scoliosis (AIS) undergoing posterior spinal instrumented fusion (PSIF). However, there are relatively few studies investigating the effect of regular multidisciplinary team meetings on level selection, surgical performance parameters, and patient outcomes after PSIF for AIS. The aim of this study was to assess changes in intra- and postoperative outcomes following multidisciplinary team meeting implementation for patients undergoing PSIF for AIS...
March 17, 2024: Spine Deformity
https://read.qxmd.com/read/38493247/a-new-model-using-deep-learning-to-predict-recurrence-after-surgical-resection-of-lung-adenocarcinoma
#2
JOURNAL ARTICLE
Pil-Jong Kim, Hee Sang Hwang, Gyuheon Choi, Hyun-Jung Sung, Bokyung Ahn, Ji-Su Uh, Shinkyo Yoon, Deokhoon Kim, Sung-Min Chun, Se Jin Jang, Heounjeong Go
This study aimed to develop a deep learning (DL) model for predicting the recurrence risk of lung adenocarcinoma (LUAD) based on its histopathological features. Clinicopathological data and whole slide images from 164 LUAD cases were collected and used to train DL models with an ImageNet pre-trained efficientnet-b2 architecture, densenet201, and resnet152. The models were trained to classify each image patch into high-risk or low-risk groups, and the case-level result was determined by multiple instance learning with final FC layer's features from a model from all patches...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38493228/the-italian-registry-of-families-at-risk-for-pancreatic-cancer-irfarpc-implementation-and-evolution-of-a-national-program-for-pancreatic-cancer-surveillance-in-high-risk-individuals
#3
REVIEW
Livia Archibugi, Fabio Casciani, Silvia Carrara, Erica Secchettin, Massimo Falconi, Gabriele Capurso, Salvatore Paiella
Screening programs for early detection and treatment of pancreatic cancer (PC) and its precursor lesions are increasingly implemented worldwide to reduce disease-specific lethality. Given the relatively low prevalence of the disease, the ideal target of such approaches is an enriched cohort of individuals harboring a lifetime risk of developing PC significantly higher compared to the general population, given either a substantial aggregation of PC cases in their family (i.e. familial pancreatic cancer) or a genomic landscape enriched with pathogenic variants associated with pancreatic carcinogenesis (i...
March 16, 2024: Familial Cancer
https://read.qxmd.com/read/38493220/mitochondrial-variants-of-complex-i-genes-associated-with-leprosy-clinical-subtypes
#4
JOURNAL ARTICLE
Felipe Gouvea de Souza, Caio S Silva, Gilderlanio S de Araújo, Mayara N Santana-da-Silva, Angélica Rita Gobbo, Moisés Batista da Silva, Pablo Pinto, Patrícia Fagundes da Costa, Claudio Guedes Salgado, Ândrea Ribeiro-Dos-Santos, Giovanna C Cavalcante
Leprosy is a chronic bacterial infection mainly caused by Mycobacterium leprae that primarily affects skin and peripheral nerves. Due to its ability to absorb carbon from the host cell, the bacillus became dependent on energy production, mainly through oxidative phosphorylation. In fact, variations in genes of Complex I of oxidative phosphorylation encoded by mtDNA have been associated with several diseases in humans, including bacterial infections, which are possible influencers in the host response to leprosy...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38493042/metabolic-etiologies-in-children-with-infantile-epileptic-spasm-syndrome-experience-at-a-tertiary-pediatric-neurology-center
#5
JOURNAL ARTICLE
Merve Feyza Yüksel, Neslihan Doğulu, Miraç Yıldırım, Engin Köse, Ömer Bektaş, Fatma Tuba Eminoğlu, Serap Teber
OBJECTIVE: Infantile epileptic spasm syndrome (IESS), including West syndrome (WS) and infantile spasm (IS), causes a challenging prognosis, particularly when associated with metabolic etiologies. METHODS: This study, conducted at a tertiary pediatric neurology center, explored the prevalence and clinical features of inborn errors of metabolism in 112 children with IESS over 10 years. RESULTS: Most patients presented with seizures, primarily flexor spasms, and the median age at onset was 5 months...
March 16, 2024: Brain & Development
https://read.qxmd.com/read/38492778/high-grade-non-sarcomatoid-chromophobe-renal-cell-carcinoma-a-series-of-22-cases-with-novel-molecular-features-on-a-subset
#6
JOURNAL ARTICLE
Ezra G Baraban, Roy Elias, Ming-Tseh Lin, Yasser Ged, Jing Zhu, Aparna Pallavajjala, Nirmish Singla, Tamara L Lotan, Pedram Argani, James R Eshleman, Jonathan I Epstein
Chromophobe renal cell carcinoma (ChRCC) is the third most common subtype of renal cell carcinoma, and typically exhibits indolent behavior, though a rare subset can exhibit high-grade morphological features and are associated with a poor prognosis. Although there is limited data on the molecular characteristics of metastatic and sarcomatoid ChRCC, the molecular features of high-grade non-sarcomatoid ChRCC remain unexplored. Herein, we characterize 22 cases of ChRCC with high-grade, non-sarcomatoid components...
March 14, 2024: Modern Pathology
https://read.qxmd.com/read/38492730/initial-outcomes-of-the-gore-tag-thoracic-branch-endoprosthesis-for-endovascular-repair-of-blunt-thoracic-aortic-injury
#7
JOURNAL ARTICLE
Elizabeth L Chou, Eileen Lu, Michael D Dake, Michael P Fischbein, Joseph E Bavaria, Gustavo Oderich, Michel S Makaroun, Kristofer M Charlton-Ouw, Thomas Naslund, Bjoern D Suckow, Jon S Matsumura, Himanshu J Patel, Ali Azizzadeh
OBJECTIVE: Endovascular repair of blunt thoracic aortic injury (BTAI) has dramatically reduced the morbidity and mortality of intervention. Injuries requiring zone 2 coverage of the aorta traditionally require left subclavian artery (LSA) sacrifice or open revascularization. Furthermore, these injuries are associated with increased risk of in-hospital mortality and long-term morbidity. Here we report 1-year outcomes of total endovascular repair of BTAI with the GORE® TAG® Thoracic Branch Endoprosthesis for LSA preservation...
March 14, 2024: Annals of Vascular Surgery
https://read.qxmd.com/read/38492616/a-review-regarding-the-article-the-cardioprotective-potential-of-sodium-glucose-cotransporter-2-inhibitors-in-breast-cancer-therapy-related-cardiac-dysfunction-a-systematic-review
#8
REVIEW
Gang Zhao, Lei Wang, Hong Fang, Liwei Wang
Breast cancer is one of the most common types of cancer, representing 15% of all new cancer cases in the United States. Approximately 12.4% of all women will be diagnosed with breast cancer during their lifetime. In the past decades, a decrease in cancer-related mortality is evident as a result of early screening and improved therapeutic options. Nonetheless, breast cancer survivors face long-term treatment side effects, with cardiotoxicity being the most significant one, which lead to increased morbidity and mortality...
March 14, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38492612/association-between-serum-beclin-1-level-and-cardiac-valvular-calcification-in-hemodialysis-patients
#9
REVIEW
Hayam Ahmed Hebah, Hadeer Moamen Kamel, Islam Mahmoud Bastawy, Fatma Abdelrahman Ahmed
BACKGROUND: Cardiovascular calcification is a pervasive issue throughout chronic kidney disease (CKD) progression. Autophagy, a fundamental cellular process, exerts significant influence on various cardiac pathologies, including arrhythmias, atherosclerosis, heart failure, and notably, valvular, and vascular calcifications. Beclin-1, a crucial eukaryotic protein, plays a major regulatory role in autophagy as part of the phosphatidylinositol-3-kinase (PI3K) complex. Recent evidence suggests a protective role for Beclin-1-mediated autophagy in CKD vascular calcification, raising its potential as a novel therapeutic target in this context...
March 14, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38492551/on-punctate-white-matter-lesions-in-preterm-infants-is-ultrasound-diagnosis-feasible
#10
JOURNAL ARTICLE
Philippe Quétin, Nicolas Leboucq, Charlotte Boyer, Françoise Crozier, Philippe Delachartre, Marilyne Grinand, Philippe Masson, Olivier Claris
OBJECTIVES: To observe hyperechoic nodular or punctate white matter lesions (HNPL) in a population of preterm infants using routine cranial ultrasound (cUS), to describe the characteristics of HNPL, and to compare them with punctate white matter lesions (PWML) detected in magnetic resonance imaging (MRI). DESIGN: Retrospective observational single-center cohort study. SETTING: Level 2B neonatal unit in France. PATIENTS: 307 infants born <33 weeks gestation undergoing routine cUS with a total of 961 cUS performed...
March 1, 2024: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/38492534/comprehensive-analysis-of-transcription-factor-based-molecular-subtypes-and-their-correlation-to-clinical-outcomes-in-small-cell-lung-cancer
#11
JOURNAL ARTICLE
Sehhoon Park, Tae Hee Hong, Soohyun Hwang, Simon Heeke, Carl M Gay, Jiyeon Kim, Hyun-Ae Jung, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Jong Ho Cho, Yong Soo Choi, Jhingook Kim, Young Mog Shim, Hong Kwan Kim, Lauren Averett Byers, John V Heymach, Yoon-La Choi, Se-Hoon Lee, Keunchil Park
BACKGROUND: Recent studies have reported the predictive and prognostic value of novel transcriptional factor-based molecular subtypes in small-cell lung cancer (SCLC). We conducted an in-depth analysis pairing multi-omics data with immunohistochemistry (IHC) to elucidate the underlying characteristics associated with differences in clinical outcomes between subtypes. METHODS: IHC (n = 252), target exome sequencing (n = 422), and whole transcriptome sequencing (WTS, n = 189) data generated from 427 patients (86...
March 15, 2024: EBioMedicine
https://read.qxmd.com/read/38492254/different-measures-of-alcohol-use-as-predictors-of-dsm-5-alcohol-use-disorder-among-adolescents-a-cohort-study-from-sweden
#12
JOURNAL ARTICLE
Jonas Raninen, Patrik Karlsson, Sarah Callinan, Thor Norström
BACKGROUND AND AIMS: This study addresses a significant gap in existing research by investigating the longitudinal relationship between various measures of alcohol use and the development of alcohol use disorders (AUDs) in a cohort of Swedish adolescents. METHODS: A prospective longitudinal survey was conducted on 3999 adolescents in Sweden who were in 9th grade in 2017 and were followed up in 2019. Baseline assessments included lifetime alcohol use, recent use (past 30 days), risky drinking (AUDIT-C), and heavy episodic drinking (HED)...
March 12, 2024: Drug and Alcohol Dependence
https://read.qxmd.com/read/38492196/incidence-and-risk-factors-for-hiv-tuberculosis-coinfection-in-the-cologne-bonn-region-a-retrospective-cohort-study
#13
JOURNAL ARTICLE
Isabelle Suárez, Dominic Rauschning, Cora Schüller, Anna Hagemeier, Melanie Stecher, Clara Lehmann, Philipp Schommers, Stefan Schlabe, Jörg-Janne Vehreschild, Carolin Koll, Carolynne Schwarze-Zander, Jan-Christian Wasmuth, Angela Klingmüller, Jürgen Kurt Rockstroh, Gerd Fätkenheuer, Christoph Boesecke, Jan Rybniker
PURPOSE: The risk of developing active tuberculosis (TB) is considerably increased in people living with HIV/AIDS (PLWH). However, incidence of HIV/TB coinfection is difficult to assess as surveillance data are lacking in many countries. Here, we aimed to perform a quantitative analysis of HIV/TB coinfections within the Cologne/Bonn HIV cohort and to determine risk factors for active TB. METHODS: We systematically evaluated data of patients with HIV/TB coinfection between 2006 and 2017...
March 16, 2024: Infection
https://read.qxmd.com/read/38492115/diabetes-and-the-risk-of-bladder-cancer-subtypes-in-men-and-women-results-from-the-netherlands-cohort-study
#14
JOURNAL ARTICLE
Piet A van den Brandt
Meta-analyses have shown modest positive associations between diabetes mellitus (DM) and bladder cancer risk, but results are heterogeneous. This might be due to lack of distinction between bladder cancer subtypes, between sexes, and possibly between Type 2 and Type 1 DM (T2DM and T1DM). The relationship of T2DM (and secondarily T1DM) characteristics with risk of bladder cancer subtypes (invasive versus noninvasive) was investigated in the Netherlands Cohort Study. In 1986, 120,852 men and women aged 55-69 years provided information on DM and lifestyle data...
March 16, 2024: European Journal of Epidemiology
https://read.qxmd.com/read/38492083/the-contradictive-findings-between-ultrasound-hysteroscopy-and-cytokines-in-women-with-nonhormonal-iuds-suffering-from-menorrhagia-a-prospective-study
#15
JOURNAL ARTICLE
Hadel Watad, Udi Ifrach, David Stockheim, Vered Yulzari, Orly C Meron, Miri Blank, Benjamin Sredni, Boaz Weisz, Shlomo B Cohen
PURPOSE: The objective of this study is to assess the correlation between bleeding irregularities and the accurate placement of the intrauterine device (IUD) device in the uterine cavity, determined through transvaginal ultrasonography and hysteroscopy. In addition, the study aims to examine the cytokine profile in the uterine cavity and serum of patients experiencing bleeding irregularities after the insertion of nonhormonal IUDs. METHODS: A prospective cohort study was conducted at a single tertiary medical center, wherein patients experiencing intermenstrual bleeding and spotting after the insertion of nonhormonal IUDs were enrolled...
March 16, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38492082/pregnancy-in-myasthenia-gravis-a-retrospective-analysis-of-maternal-and-neonatal-outcome-from-a-large-tertiary-care-centre-in-germany
#16
JOURNAL ARTICLE
Jakob Draxler, Andreas Meisel, Frauke Stascheit, Maike Stein, Lea Gerischer, Philipp Mergenthaler, Meret Herdick, Paolo Doksani, Sophie Lehnerer, Stefan Verlohren, Sarah Hoffmann
PURPOSE: Myasthenia gravis (MG) is a rare, potentially life-threatening autoimmune disease with fluctuating muscle weakness frequently affecting women of childbearing age. MG can affect maternal as well as neonatal outcome with risk of worsening of myasthenic symptoms in the mothers and risk of transient neonatal myasthenia gravis (TNMG) and arthrogryposis multiplex congenita (AMC) or foetal acetylcholine receptor antibody-associated disorders (FARAD) in the neonates. METHODS: Retrospective analysis of maternal and neonatal outcome in a cohort of pregnant MG patients treated at a tertiary care centre in Germany...
March 16, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38492064/clinical-outcomes-of-patellofemoral-arthroplasty-robotic-assistance-produces-superior-short-and-mid-term-outcomes
#17
JOURNAL ARTICLE
Jonathan L Katzman, Weston Buehring, Muhammad A Haider, Patrick Connolly, Ran Schwarzkopf, Ivan Fernandez-Madrid
INTRODUCTION: Patellofemoral arthroplasty (PFA) has been shown to provide symptomatic improvement for isolated patellofemoral osteoarthritis (PFOA). The efficacy of robotic-assisted PFA and the most suitable PFA implant design, however, remain ongoing matters of debate. This study sought to compare clinical outcomes between patients who underwent robotic-assisted versus conventional PFAs with inlay and onlay prosthetic designs. METHODS: A single-center retrospective review found 237 knees (211 patients) which underwent PFA between 2011 and 2021...
March 16, 2024: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/38492003/implementation-of-single-port-robotic-urologic-surgery-experience-at-a-large-academic-center
#18
JOURNAL ARTICLE
Francesco Ditonno, Antonio Franco, Leslie Claire Licari, Eugenio Bologna, Celeste Manfredi, David O Katz, Jonathan H Huang, Kalyan C Latchamsetty, Christopher L Coogan, Edward E Cherullo, Alexander K Chow, Srinivas Vourganti, Riccardo Autorino
The Single-Port (SP) robotic system is increasingly being implemented in the United States, allowing for several minimally invasive urologic procedures to be performed. The present study aims to describe our single-center experience since the adoption of the SP platform. We retrospectively collected and analyzed consecutive SP cases performed at a major teaching hospital in the Midwest (Rush University Medical Center) from December 2020 to December 2023. Demographic variables were collected. Surgical and pathological outcomes were analyzed in the overall cohort and for each type of procedure...
March 16, 2024: Journal of Robotic Surgery
https://read.qxmd.com/read/38491995/public-versus-private-care-in-the-military-health-system-evidence-from-low-back-pain-patients
#19
JOURNAL ARTICLE
Christopher G Leggett, Rachel O Schmidt, Jonathan Skinner, Jon D Lurie, William Patrick Luan
INTRODUCTION: There is a longstanding debate about whether health care is more efficiently provided by the public or private sector. The debate is particularly relevant to the Military Health System (MHS), which delivers care through a combination of publicly funded federal facilities and privately contracted providers. This study compares outcomes, treatments, and costs for MHS patients obtaining care for low back pain (LBP) from public versus private providers. MATERIALS AND METHODS: A retrospective cohort study was completed using TRICARE Prime claims data from April 2015 to December 2018...
March 16, 2024: Military Medicine
https://read.qxmd.com/read/38491857/psychiatric-risks-for-worsened-mental-health-after-psychedelic-use
#20
JOURNAL ARTICLE
Alessia Marrocu, Hannes Kettner, Brandon Weiss, Richard J Zeifman, David Erritzoe, Robin L Carhart-Harris
BACKGROUND: Resurgent psychedelic research has largely supported the safety and efficacy of psychedelic therapy for the treatment of various psychiatric disorders. As psychedelic use and therapy increase in prevalence, so does the importance of understanding associated risks. Cases of prolonged negative psychological responses to psychedelic therapy seem to be rare; however, studies are limited by biases and small sample sizes. The current analytical approach was motivated by the question of whether rare but significant adverse effects have been under-sampled in psychedelic research studies...
March 2024: Journal of Psychopharmacology
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