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https://www.readbyqxmd.com/read/28502899/the-expression-of-p450-genes-mediating-fenpropathrin-resistance-is-regulated-by-cncc-and-maf-in-tetranychus-cinnabarinus-boisduval
#1
Li Shi, Mengyao Wang, Yichao Zhang, Guangmao Shen, Haishan Di, Yue Wang, Lin He
Although overexpression of genes encoding detoxification enzymes is a well known mechanism of pesticide resistance of mites, the regulators involved in this process are still illiterate. Previous studies in our laboratory demonstrated that the overexpression of six P450 genes contributes to fenpropathrin resistance in T. cinnabarinus. In this study, six transcription factor genes that likely regulate the expression of P450 genes were identified and characterized. Quantitative PCR (qPCR) analysis showed that three transcription factor genes were highly expressed in a fenpropathrin-resistant (FeR) strain of T...
May 11, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28499965/effects-of-dietary-dandelion-extracts-on-growth-performance-body-composition-plasma-biochemical-parameters-immune-responses-and-disease-resistance-of-juvenile-golden-pompano-trachinotus-ovatus
#2
Xiaohong Tan, Zhenzhu Sun, Shu Chen, Silin Chen, Zhong Huang, Chuanpeng Zhou, Cuiyun Zou, Qingying Liu, Huaqun Ye, Heizhao Lin, Chaoxia Ye, Anli Wang
The present study was conducted to investigate the effects of dietary dandelion extracts (DE) supplementation on growth performance, feed utilization, body composition, plasma biochemical indices, immune responses, hepatic antioxidant abilities, and resistance to the pathogen Vibrio harveyi in Trachinotus ovatus. A basal diet supplemented with DE at 0, 0.50, 1.00, 2.00, 4.00 and 10.00 g kg(-1) were fed to golden pompano for 8 weeks. The study indicated that dietary supplementation with DE could significantly improve final body weight (FBW), weight gain rate (WGR), specific growth rate (SGR), feed efficiency ratio (FER), feed intake (FI), protein efficiency ratio (PER) and protein deposit rate (PDR) (P < 0...
May 9, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28497246/neural-correlates-of-explicit-versus-implicit-facial-emotion-processing-in-asd
#3
Christina Luckhardt, Anne Kröger, Hannah Cholemkery, Stephan Bender, Christine M Freitag
The underlying neural mechanisms of implicit and explicit facial emotion recognition (FER) were studied in children and adolescents with autism spectrum disorder (ASD) compared to matched typically developing controls (TDC). EEG was obtained from N = 21 ASD and N = 16 TDC. Task performance, visual (P100, N170) and cognitive (late positive potential) event-related-potentials, as well as coherence were compared across groups. TDC showed a task-dependent increase and a stronger lateralization of P100 amplitude during the explicit task and task-dependent modulation of intra-hemispheric coherence in the beta band...
May 11, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28486704/cost-effectiveness-analysis-of-lifestyle-intervention-in-obese-infertile-women
#4
A M van Oers, M A Q Mutsaerts, J M Burggraaff, W K H Kuchenbecker, D A M Perquin, C A M Koks, R van Golde, E M Kaaijk, J M Schierbeek, N F Klijn, Y M van Kasteren, J A Land, B W J Mol, A Hoek, H Groen
STUDY QUESTION: What is the cost-effectiveness of lifestyle intervention preceding infertility treatment in obese infertile women? SUMMARY ANSWER: Lifestyle intervention preceding infertility treatment as compared to prompt infertility treatment in obese infertile women is not a cost-effective strategy in terms of healthy live birth rate within 24 months after randomization, but is more likely to be cost-effective using a longer follow-up period and live birth rate as endpoint...
May 9, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28476487/a-randomized-controlled-trial-comparing-the-efficacy-and-safety-of-two-hmg-preparations-gaining-their-lh-bioactivity-from-different-hcg-sources
#5
Gillian Lockwood, Barbara Cometti, Jeanette Bogstad, Karin Erb, Christian De Geyter, Janos Urbancsek, Silvia Trevisan, Khaled Pocate-Cheriet, Dominique de Ziegler
In this prospective, controlled, randomized, multicentre, non-inferiority study, efficacy and safety of two HMG preparations (Menopur(®)- Ferring and Meriofert®- IBSA Institut Biochimique SA) for ovarian stimulation were compared (270 women undergoing IVF aged between 18 and 39 years; BMI 30 kg/m(2) or less; less than three prior completed assisted reproduction technique cycles). A standard long down-regulation with gonadotrophin-releasing hormone agonist protocol, with HCG triggering was used; primary end-point was total number of oocytes retrieved; attention was paid toovarian hyperstimulation syndrome (OHSS)...
April 20, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28472455/the-long-term-prognosis-for-live-birth-in-couples-initiating-fertility-treatments
#6
S S Malchau, A A Henningsen, A Loft, S Rasmussen, J Forman, A Nyboe Andersen, A Pinborg
STUDY QUESTION: What are the long-term chances of having a child for couples starting fertility treatments and how many conceive with ART, IUI and without treatment? SUMMARY ANSWER: Total 5-year live birthrates were strongly influenced by female age and ranged from 80% in women under 35-26% in women ≥40 years, overall, 14% of couples conceived naturally and one-third of couples starting treatments with intrauterine insemination delivered from that treatment. WHAT IS KNOWN ALREADY: Few studies report success rates in fertility treatments across a couple's complete fertility treatment history, across clinics, evaluating live births after insemination, ART and natural conceptions...
May 4, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28471688/atherogenic-impact-of-lecithin-cholesterol-acyltransferase-and-its-relation-to-cholesterol-esterification-rate-in-hdl-fer-hdl-and-aip-log-tg-hdl-c-biomarkers-the-butterfly-effect
#7
M Dobiášová
The atherogenic impact and functional capacity of LCAT was studied and discussed over a half century. This review aims to clarify the key points that may affect the final decision on whether LCAT is an anti-atherogenic or atherogenic factor. There are three main processes involving the efflux of free cholesterol from peripheral cells, LCAT action in intravascular pool where cholesterol esterification rate is under the control of HDL, LDL and VLDL subpopulations, and finally the destination of newly produced cholesteryl esters either to the catabolism in liver or to a futile cycle with apoB lipoproteins...
May 4, 2017: Physiological Research
https://www.readbyqxmd.com/read/28461335/mechanism-of-ubiquitin-chain-synthesis-employed-by-a-hect-ubiquitin-ligase
#8
Michael E French, Julian L Klosowiak, Aaron Aslanian, Steven I Reed, John R Yates, Tony Hunter
Homologous to E6AP Carboxyl Terminus (HECT) ubiquitin (Ub) ligases (E3s) are a large class of enzymes that bind to their substrates and catalyze ubiquitination through the formation of a Ub thioester intermediate. The mechanisms by which these E3s assemble polyubiquitin chains on their substrates remain poorly defined. We report here that the Nedd4 family HECT E3, WWP1, assembles substrate-linked Ub chains containing K63, K48, and K11 linkages (K63 > K48 > K11). Our results demonstrate that WWP1 catalyzes the formation of Ub chains through a sequential addi-tion mechanism, in which Ub monomers are trans-ferred in a successive fashion to the substrate, and that ubiquitination by WWP1 requires the pres-ence of a low-affinity, noncovalent Ub-binding site within the HECT domain...
May 1, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28459452/targeting-genomic-rearrangements-in-tumor-cells-through-cas9-mediated-insertion-of-a-suicide-gene
#9
Zhang-Hui Chen, Yan P Yu, Ze-Hua Zuo, Joel B Nelson, George K Michalopoulos, Satdatshan Monga, Silvia Liu, George Tseng, Jian-Hua Luo
Specifically targeting genomic rearrangements and mutations in tumor cells remains an elusive goal in cancer therapy. Here, we used Cas9-based genome editing to introduce the gene encoding the prodrug-converting enzyme herpes simplex virus type 1 thymidine kinase (HSV1-tk) into the genomes of cancer cells carrying unique sequences resulting from genome rearrangements. Specifically, we targeted the breakpoints of TMEM135-CCDC67 and MAN2A1-FER fusions in human prostate cancer or hepatocellular carcinoma cells in vitro and in mouse xenografts...
May 1, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28453688/edlib-a-c-c%C3%A2-library-for-fast-exact-sequence-alignment-using-edit-distance
#10
Martin Šošic, Mile Šikic
Summary: We present Edlib, an open-source C/C ++ library for exact pairwise sequence alignment using edit distance. We compare Edlib to other libraries and show that it is the fastest while not lacking in functionality and can also easily handle very large sequences. Being easy to use, flexible, fast and low on memory usage, we expect it to be easily adopted as a building block for future bioinformatics tools. Availability and Implementation: Source code, installation instructions and test data are freely available for download at https://github...
May 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28450880/development-of-molecular-markers-for-iron-metabolism-related-genes-in-lentil-and-their-expression-analysis-under-excess-iron-stress
#11
Debjyoti Sen Gupta, Kevin McPhee, Shiv Kumar
Multiple genes and transcription factors are involved in the uptake and translocation of iron in plants from soil. The sequence information about iron uptake and translocation related genes is largely unknown in lentil (Lens culinaris Medik.). This study was designed to develop iron metabolism related molecular markers for Ferritin-1, BHLH-1 (Basic helix loop helix), or FER-like transcription factor protein and IRT-1 (Iron related transporter) genes using genome synteny with barrel medic (Medicago truncatula)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28444222/feronia-receptor-kinase-at-the-crossroad-of-hormone-signaling-and-stress-responses
#12
Hongdong Liao, Renjie Tang, Xin Zhang, Sheng Luan, Feng Yu
Plant receptor-like kinases (RLKs) are involved in nearly all aspects of plant life including growth, development and stress response. Recent studies show that FERONIA (FER), a CrRLK1L subfamily member, is a versatile regulator of cell expansion and serves as a signaling node mediating crosstalks among multiple phytohormones. As a receptor for the RALF (Rapid Alkalinization Factor) peptide ligand, FER triggers a downstream signaling cascade that leads to a rapid cytoplasmic calcium increase and inhibition of cell elongation in plants...
April 19, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28418646/the-influence-of-nanostructure-on-the-exciton-dynamics-of-multichromophore-donor-acceptor-block-copolymers
#13
Jianlong Xia, Erik Busby, Samuel N Sanders, Clarion Tung, Angelo Cacciuto, Matthew Y Sfeir, Luis M Campos
We explore the synthesis and photophysics of nanostructured block copolymers that mimic light harvesting complexes. We find that the combination of a polar and electron rich block with a non-polar electron poor block yields a polymer which self-assembles into ordered "nanoworms". Numerical simulations are used to determine optimal compositions to achieve robust self-assembly. Photolumi-nescence spectroscopy is used to probe the rich exciton dynamics in these systems. Using controls, such as homopolymers and random copolymers we analyze the mechanisms of the photoluminescence from these polymers...
April 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/28386601/on-the-mechanism-of-cytoprotection-by-ferrostatin-1-and-liproxstatin-1-and-the-role-of-lipid-peroxidation-in-ferroptotic-cell-death
#14
Omkar Zilka, Ron Shah, Bo Li, José Pedro Friedmann Angeli, Markus Griesser, Marcus Conrad, Derek A Pratt
Ferroptosis is a form of regulated necrosis associated with the iron-dependent accumulation of lipid hydroperoxides that may play a key role in the pathogenesis of degenerative diseases in which lipid peroxidation has been implicated. High-throughput screening efforts have identified ferrostatin-1 (Fer-1) and liproxstatin-1 (Lip-1) as potent inhibitors of ferroptosis - an activity that has been ascribed to their ability to slow the accumulation of lipid hydroperoxides. Herein we demonstrate that this activity likely derives from their reactivity as radical-trapping antioxidants (RTAs) rather than their potency as inhibitors of lipoxygenases...
March 22, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28362472/nutritional-value-and-chemical-composition-of-sudanese-millet-based-fermented-foods-as-affected-by-fermentation-and-method-of-preparation
#15
Abdalbasit A Mariod, Yousif M A Idris, Nuha M Osman, Maha A Mohamed, Awad M A Sukrab, Bertrand Matthaus
BACKGROUND: Although kissra and hulu-mur are well known millet-based foods in Sudan, the effect of fer- mentation and methods of preparation on their chemical compositions has not been thoroughly investigated. The aim of this study was to investigate the method of preparation and the composition of kisra, and hulu-mur. METHODS: The effect of fermentation and method of preparation on the composition, and mi- crobiological load were examined in millet flour during the preparation of Sudanese fermented foods (kisra & hulu-mur)...
January 2017: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28356966/stromal-expression-of-fer-suppresses-tumor-progression-in-renal-cell-carcinoma-and-is-a-predictor-of-survival
#16
Kensuke Mitsunari, Yasuyoshi Miyata, Shin-Ichi Watanabe, Akihiro Asai, Takuji Yasuda, Shigeru Kanda, Hideki Sakai
Fps/Fes related (Fer) is a non-receptor tyrosine kinase that is expressed in fibroblasts, immune cells and endothelial cells. Fer serves an important pathological role in cell survival, angiogenesis and the immune system. However, the pathological role of Fer expression in the stromal cells surrounding renal cell carcinoma (RCC) has not been previously investigated. In the present study, immunohistochemical analysis of Fer was performed using the formalin-fixed tissue samples of 152 patients with RCC. The proliferative and apoptotic indices were used to represent the percentage of proliferation marker protein Ki-67- and cleaved caspase-3-positive cells, respectively...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28356947/downregulation-of-feline-sarcoma-related-protein-inhibits-cell-migration-invasion-and-epithelial-mesenchymal-transition-via-the-erk-ap-1-pathway-in-bladder-urothelial-cell-carcinoma
#17
Xudong Hu, Zhiqiang Zhang, Zhaofeng Liang, Dongdong Xie, Tao Zhang, Dexin Yu, Caiyun Zhong
Feline sarcoma-related protein (Fer) is a nuclear and cytoplasmic non-receptor protein tyrosine kinase and Fer overexpression is associated with various biological processes. However, the clinicopathological characteristics and molecular mechanisms of Fer expression in bladder urothelial cell carcinoma (UCC) have yet to be elucidated. The present study demonstrated that Fer was significantly upregulated in bladder UCC tissues and cell lines. A clinicopathological analysis suggested that Fer expression was significantly associated with tumor stage, histological grade and lymph node status, and Fer expression was a prognostic factor for overall survival in a multivariate analysis...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28339021/determinants-of-serum-manganese-levels-in-an-italian-population
#18
Tommaso Filippini, Bernhard Michalke, Peter Grill, Carlotta Malagoli, Marcella Malavolti, Luciano Vescovi, Sabina Sieri, Vittorio Krogh, Andrea Cherubini, Giuseppe Maffeis, Roberto Lucchini, Margherita Ferrante, Marco Vinceti
Manganese (Mn) is both essential and toxic for humans, mainly depending on the total levels and its species. Main sources of exposure include food and air pollution, particularly motorized traffic. We sought to determine the potential influence of these sources on serum total levels of Mn and Mn species. We selected a random sample of municipality residents from an Italian urban municipality, from whom we collected detailed personal information, dietary habits and a blood sample for serum Mn determination...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28333318/a-phase-iii-randomized-controlled-trial-comparing-the-efficacy-safety-and-tolerability-of-oral-dydrogesterone-versus-micronized-vaginal-progesterone-for-luteal-support-in-in-vitro-fertilization
#19
Herman Tournaye, Gennady T Sukhikh, Elke Kahler, Georg Griesinger
STUDY QUESTION: Is oral dydrogesterone 30 mg daily (10 mg three times daily [TID]) non-inferior to micronized vaginal progesterone (MVP) 600 mg daily (200 mg TID) for luteal support in in vitro fertilization (IVF), assessed by the presence of fetal heartbeats determined by transvaginal ultrasound at 12 weeks of gestation? SUMMARY ANSWER: Non-inferiority of oral dydrogesterone versus MVP was demonstrated at 12 weeks of gestation, with a difference in pregnancy rate and an associated confidence interval (CI) that were both within the non-inferiority margin...
May 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28333185/randomized-open-trial-comparing-a-modified-double-lumen-needle-follicular-flushing-system-with-a-single-lumen-aspiration-needle-in-ivf-patients-with-poor-ovarian-response
#20
Kyra von Horn, Marion Depenbusch, Askan Schultze-Mosgau, Georg Griesinger
STUDY QUESTION: Is a modified double-lumen aspiration needle system with follicular flushing able to increase the mean oocyte yield by at least one in poor response IVF patients as compared to single-lumen needle aspiration without flushing? SUMMARY ANSWER: Follicular flushing with the modified flushing system did not increase the number of oocytes, but increased the procedure duration. WHAT IS KNOWN ALREADY: Most studies on follicular flushing were performed with conventional double-lumen needles in patients who were normal responders...
April 1, 2017: Human Reproduction
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