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https://www.readbyqxmd.com/read/28302247/symptomatic-fetal-type-cardiac-rhabdomyoma
#1
Seyma Kayali, Vehbi Dogan, Ilker Ertugrul, Senem Ouml Zg Uuml R, Utku Arman Ouml R Uuml N, Selmin Karademir, Nil Uuml Fer Arda, Murat Ko Ccedil
Rhabdomyomas are the most common primary cardiac tumors, especially seen during early periods of childhood. Fetaltype rhabdomyoma is a benign tumor described almost always in extracardiac locations. Although the natural history of the cardiac rhabdomyoma is to regress, the behaviour of the fetal-type rhabdomyomas when present in the heart is unknown with respect to its infrequency. Herein, we report a hemodynamically unstable female neonate with a single large intra-cardiac mass unresponsive to medical treatment, who underwent surgery...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28279978/desmopressin-for-nocturia-in-adults
#2
(no author information available yet)
Desmopressin has been used for many years in the treatment of diabetes insipidus, nocturnal enuresis (involuntary urination while asleep) and nocturia associated with multiple sclerosis (in adults aged up to 65 years); it has also been recommended in certain circumstances for the treatment of nocturia in men and women (previously, an unlicensed use).(1,2) Recently, a new brand of desmopressin sublingual tablet (lyophilisate-an orally disintegrating tablet; Noqdirna-Ferring) has been licensed for use in adults of any age for the treatment of nocturia due to idiopathic nocturnal polyuria...
March 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28277407/iron-deficiency-and-anemia-among-collegiate-athletes-a-retrospective-chart-review
#3
Rachel B Parks, Scott J Hetzel, M Alison Brooks
PURPOSE: To describe the prevalence of anemia among incoming female college athletes and to characterize the results and expenses of iron-related testing at one NCAA Division I institution. METHODS: In this retrospective medical record review, hemoglobin (Hgb) and ferritin (Fer) lab values were obtained for student-athletes at a single institution, 2002 - 2014. Labs were collected either as part of the pre-participation exam (PPE) for female athletes, routine screening for cross country athletes, or as needed for medical evaluation...
March 8, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28250973/mpp-induces-necrostatin-1-and-ferrostatin-1-sensitive-necrotic-death-of-neuronal-sh-sy5y-cells
#4
Keisuke Ito, Yutaka Eguchi, Yusuke Imagawa, Shuji Akai, Hideki Mochizuki, Yoshihide Tsujimoto
Regulation of cell death is potentially a powerful treatment modality for intractable diseases such as neurodegenerative diseases. Although there have been many reports about the possible involvement of various types of cell death in neurodegenerative diseases, it is still unclear exactly how neurons die in patients with these diseases, thus treatment strategies based on cell death regulation have not been established yet. To obtain some insight into the mechanisms of cell death involved in neurodegenerative diseases, we studied the effect of 1-methyl-4-phenylpyridinium (MPP+) on the human neuroblastoma cell line SH-SY5Y (a widely used model of Parkinson's disease)...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28248524/biocompatible-soft-nanoparticles-with-multiple-morphologies-obtained-from-nanoprecipitation-of-amphiphilic-graft-copolymers-in-a-backbone-selective-solvent
#5
Gaëlle Le Fer, Clémence Le Cœur, Jean-Michel Guigner, Catherine Amiel, Gisèle Volet
Stealth nanocarriers are a promising technology for the treatment of diseases. However, the preparation and characterization of well-defined soft nanoparticulate systems remain challenging. Here we describe a platform of amphiphilic graft copolymers leading to nanoparticles with multiple morphologies and the role of the hydrophilic backbone in their interaction with a model protein. The amphiphilic graft copolymers platform was composed of hydrophilic backbone poly(2-methyl-2-oxazoline-co-2-pentyl-2-oxazoline) (P(MeOx-co-PentOx)), prepared via cationic ring-opening polymerization...
March 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28245430/man2a1-fer-fusion-gene-is-expressed-by-human-liver-and-other-tumor-types-and-has-oncogenic-activity-in-mice
#6
Zhang-Hui Chen, Yan P Yu, Junyan Tao, Silvia Liu, George Tseng, Michael Nalesnik, Ronald Hamilton, Rohit Bhargava, Joel B Nelson, Arjun Pennathur, Satdarshan P Monga, James D Luketich, George K Michalopoulos, Jian-Hua Luo
BACKGROUND & AIMS: Human tumors and liver cancer cell lines express the product of a fusion between the first 13 exons in the mannosidase α class 2A member 1 gene (MAN2A1) and the last 6 exons in the FER tyrosine kinase gene (FER), called MAN2A1-FER. We investigated whether MAN2A1-FER is expressed by human liver tumors and its role in liver carcinogenesis. METHODS: We performed reverse transcription polymerase chain reaction analyses of 102 non-small cell lung tumors, 61 ovarian tumors, 70 liver tumors, 156 glioblastoma multiform samples, 27 esophageal adenocarcinomas, and 269 prostate cancer samples, as well as 10 nontumor liver tissues and 20 nontumor prostate tissues, collected at the University of Pittsburgh...
February 25, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28244165/catalytic-behavior-study-of-bifunctional-hydrogen-bonding-catalysts-guided-by-free-energy-relationship-analyses-of-steric-parameters
#7
Xin Li, Chen Yang, Jie Wang, Yang Liu, Xiang Ni, JinPei Cheng
Free energy relationship (FER) studies to correlate steric parameters against enantiocatalytic performance of bifunctional tertiary-amine hydrogen-bonding type catalysts, including (S, S)-cyclohexane-1, 2-diamine derived thioureas, Cinchona alkaloid derived thioureas and (S, S)-cyclohexane-1, 2-diamine derived squaramides, for Michael reactions revealed that the Michael reactions are much favored by catalysts with less bulky N-substituents. The observed FERs are independent of chiral scaffold and hydrogen-bond donors, deepening the understanding of current bifunctional hydrogen-bonding catalysts...
February 28, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28238904/proteomic-toxicological-and-immunogenic-characterization-of-mexican-west-coast-rattlesnake-crotalus-basiliscus-venom-and-its-immunological-relatedness-with-the-venom-of-central-american-rattlesnake-crotalus-simus
#8
Álvaro Segura, María Herrera, Francisco Reta Mares, Claudia Jaime, Andrés Sánchez, Mariángela Vargas, Mauren Villalta, Aarón Gómez, José María Gutiérrez, Guillermo León
The venom of the Mexican west-coast rattlesnake (Crotalus basiliscus) was characterized for its protein composition, toxicological profile and immunogenic properties. This venom is composed of 68% Zn(2+)-dependent metalloproteinases (SVMPs), 14% phospholipases A2 (PLA2s), 11% serine proteinases, 4% SVMPs-inhibitor tripeptides (SVMP-ITs), 2% bradykinin-potentiating peptides (BPPs), 0.6% cysteine-rich secretory proteins (CRISPs), and 0.2% l-amino acid oxidases (LAAOs). SVMPs present in the venom are responsible for azocasein hydrolysis and hemorrhagic activity, but their contribution to the lethal activity of the venom in mice is masked by the neurotoxic activity of PLA2s, which in addition are also responsible for myotoxic activity...
February 24, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28238779/daily-activity-rhythms-and-the-stress-related-response-in-the-wedge-sole-dicologoglossa-cuneata-moreau-1881
#9
E De la Roca, B Sánchez, J M López, M A Herves, A Canalejo, M Herrera
To gain further insights on the wedge sole (Dicologoglossa cuneata Moreau, 1881) physiology and behavior, we evaluated its daily feeding and locomotor activity rhythms and compared three different feeding strategies: self-feeding (SF), diurnal feeding schedule (DS) and nocturnal feeding schedule (NS). 450 fish divided into three groups (three replicates each), were kept during 65days. SF had free access to self-feeders whereas DS and NS were fed four times a day. Physiological stress parameters as plasma cortisol, glucose, lactate, proteins and triglycerides were determined...
February 24, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28230288/a-dual-label-time-resolved-fluorescence-immunoassay-for-the-simultaneous-determination-of-ferritin-and-%C3%AE-2-microglobulin
#10
Zhi Liu, Jing Huang, Rui-Ming Ou, Meng-Dong Yao, Yan-Lin She, Rui Chen, Cheng Li, Li Xu, Aikebaier Abudureyimu, Qing Zhang, Shuang Liu
BACKGROUND: Lymphocytic leukemia is a kind of primary malignant tumor of hematopoietic tissue. The aim was to establish a dual-label time-resolved fluorescence immunoassay (TRFIA) for the simultaneous determination of ferritin (FER) and β2 -microglobulin (β2 -MG) for the early screening and follow-up surveillance of lymphocytic leukemia. METHODS: The sandwich immunoassay was used to detect the concentration of FER, and the competitive immunoassay was used to detect the concentration of β2 -MG in serum...
February 23, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28220679/the-lac-m%C3%A3-gantic-derailment-corporate-regulation-and-neoliberal-sovereignty
#11
David Tyler Dunford
On July 6, 2013, Montreal, Maine, and Atlantic railcar 5017 hauling 72 tanker cars of Bakken crude oil derailed over the town of Lac-Mégantic, Quebec. The town erupted in a fiery inferno as 5,560,000 liters of highly flammable Bakken crude oil exploded over the town, killing 47 people and contaminating 558,000 tons of soil and local waterways. While Montreal, Maine, and Atlantic Rail Chairman Edward Burkhardt initially blamed the derailment on the lone engineer and local firefighters, this study shows how Transport Canada and the rail industry undermined regulatory and safety measures for several years before the derailment...
February 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28188206/insight-into-the-carbon-source-dependent-inducible-veratrylalcohol-and-ferulic-acid-metabolism-in-pseudomonas-putida-csv86
#12
Karishma Mohan, Prashant S Phale
Pseudomonas putida CSV86 degrades lignin-derived metabolic intermediates viz veratrylalcohol, ferulic acid, vanillin and vanillic acid as a sole source of carbon and energy. Strain CSV86 also displayed the ability to degrade lignin sulphonate. Cell respiration, enzyme activity, biotransformation and HPLC analysis suggests that veratyralcohol and ferulic acid are metabolized to vanillic acid by two distinct carbon-source dependent inducible pathways. Vanillic acid was further metabolized to protocatechuic acid and enters the central carbon pathway viaβ-ketoadipate route after ortho ring-cleavage...
February 10, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28154778/surgical-treatment-of-intrahepatic-cholangiocarcinoma-a-retrospective-study-of-104-cases
#13
Xiao-Dong Xun, Qiang Li
OBJECTIVE: To explore the clinicopathological features, surgical treatment techniques, and prognostic risk factors of intrahepatic cholangiocarcinoma (ICC). METHODS: A total of 104 ICC cases were collected from January 2008 to December 2013 at Tianjin Medical University Cancer Institute and Hospital and divided into the hepatic hilum lymphadenectomy (HLL, 21 cases), extended hepatic hilum lymphadenectomy (EHLL, 12 cases), and non-lymphadenectomy (NL, 71 cases) groups...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28137754/efficacy-and-safety-of-follitropin-alfa-lutropin-alfa-in-art-a-randomized-controlled-trial-in-poor-ovarian-responders
#14
P Humaidan, W Chin, D Rogoff, T D'Hooghe, S Longobardi, J Hubbard, J Schertz
STUDY QUESTION: How does the efficacy and safety of a fixed-ratio combination of recombinant human FSH plus recombinant human LH (follitropin alfa plus lutropin alfa; r-hFSH/r-hLH) compare with that of r-hFSH monotherapy for controlled ovarian stimulation (COS) in patients with poor ovarian response (POR)? SUMMARY ANSWER: The primary and secondary efficacy endpoints were comparable between treatment groups and the safety profile of both treatment regimens was favourable...
January 30, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28109190/qtl-mapping-and-candidate-genes-for-resistance-to-fusarium-ear-rot-and-fumonisin-contamination-in-maize
#15
Valentina Maschietto, Cinzia Colombi, Raul Pirona, Giorgio Pea, Francesco Strozzi, Adriano Marocco, Laura Rossini, Alessandra Lanubile
BACKGROUND: Fusarium verticillioides is a common maize pathogen causing ear rot (FER) and contamination of the grains with the fumonisin B1 (FB1) mycotoxin. Resistance to FER and FB1 contamination are quantitative traits, affected by environmental conditions, and completely resistant maize genotypes to the pathogen are so far unknown. In order to uncover genomic regions associated to reduced FER and FB1 contamination and identify molecular markers for assisted selection, an F2:3 population of 188 progenies was developed crossing CO441 (resistant) and CO354 (susceptible) genotypes...
January 21, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28104890/the-receptor-kinase-fer-is-a-ralf-regulated-scaffold-controlling-plant-immune-signaling
#16
Martin Stegmann, Jacqueline Monaghan, Elwira Smakowska-Luzan, Hanna Rovenich, Anita Lehner, Nicholas Holton, Youssef Belkhadir, Cyril Zipfel
In plants, perception of invading pathogens involves cell-surface immune receptor kinases. Here, we report that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RALF) propeptides to inhibit plant immunity. This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced complex formation of the immune receptor kinases EF-TU RECEPTOR (EFR) and FLAGELLIN-SENSING 2 (FLS2) with their co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) to initiate immune signaling...
January 20, 2017: Science
https://www.readbyqxmd.com/read/28104412/features-of-the-broader-autism-phenotype-in-people-with-epilepsy-support-shared-mechanisms-between-epilepsy-and-autism-spectrum-disorder
#17
REVIEW
Annie E Richard, Ingrid E Scheffer, Sarah J Wilson
Richard, A.E., I.E. Scheffer and S.J. Wilson. Features of the broader autism phenotype in people with epilepsy support shared mechanisms between epilepsy and autism spectrum disorder. NEUROSCI BIOBEHAV REV 21(1) XXX-XXX, 2016. To inform on mechanisms underlying the comorbidity of epilepsy and autism spectrum disorder (ASD), we conducted meta-analyses to test whether impaired facial emotion recognition (FER) and theory of mind (ToM), key phenotypic traits of ASD, are more common in people with epilepsy (PWE) than controls...
January 16, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28104335/soil-water-and-nutrient-losses-from-management-alternatives-for-degraded-pasture-in-brazilian-atlantic-rainforest-biome
#18
Paulo Roberto da Rocha Junior, Felipe Vaz Andrade, Eduardo de Sá Mendonça, Guilherme Kangussú Donagemma, Raphael Bragança Alves Fernandes, Rabin Bhattharai, Prasanta Kumar Kalita
The objective of this study was to evaluate sediment, water and nutrient losses from different pasture managements in the Atlantic Rainforest biome. A field study was carried out in Alegre Espiríto Santo, Brazil, on a Xanthic Ferralsol cultivated with braquiaria (Brachiaria brizantha). The six pasture managements studied were: control (CON), chisel (CHI), fertilizer (FER), burned (BUR), plowing and harrowing (PH), and integrated crop-livestock (iCL). Runoff and sediment samples were collected and analyzed for calcium (Ca), magnesium (Mg), potassium (K), phosphorus (P) and organic carbon contents...
January 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28074978/-effect-of-meal-frequency-and-carbohydrate-intake-on-the-metabolic-control-of-patients-with-type-2-diabetes-mellitus
#19
Tamara Leiva, Karen Basfi-Fer, Pamela Rojas, Fernando Carrasco, Manuel Ruz O
BACKGROUND: Increasing meal frequency is commonly used in the clinical practice as part of the nutritional treatment of patients with type 2 Diabetes Mellitus (DM2), although its effect on metabolic control parameters is controversial. AIM: To evaluate the association of energy intake, meal frequency, and amount of carbohydrates with fasting plasma glucose and glycosylated hemoglobin in a group of patients with DM2 without insulin therapy. MATERIAL AND METHODS: Dietary intake was evaluated in 60 subjects with DM2 through three-day food records...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28060498/1-8-cineole-in-french-red-wines-evidence-for-a-contribution-related-to-its-various-origins
#20
Xavier Poitou, Cécile Thibon, Philippe Darriet
The aromatic descriptor "green", reflecting grape unripeness in French red wines, is frequently associated with the levels of 3-alkyl-2-methoxypyrazines, particularly 3-isobutyl-2-methoxypyrazine (IBMP), which has bell pepper nuances. Nevertheless, not all green aromatic expressions in red wines correlate with 3-alkyl-2-methoxypyrazine concentrations. This study considered sensory and chemical approaches using Cabernet Sauvignon wines obtained from grapes harvested at one-month intervals during the 2014 and 2015 vintages to investigate other volatile odoriferous compounds...
January 18, 2017: Journal of Agricultural and Food Chemistry
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