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https://www.readbyqxmd.com/read/28647652/kinase-activity-in-recurring-primary-skull-base-chordomas-and-chondrosarcomas-identification-of-novel-pathways-of-oncogenesis-and-potential-drug-targets
#1
Philip Tatman, Joshua Osbun, Youssef Yakkioui, Sumanpret Kaur, Carolina Parada, Tina Busald, Donald Born, Owais Ahmad, Jing Zhang, Manuel Ferreira
OBJECTIVE: Chordomas and chondrosarcomas are tumors that can occur in the skull base. Currently, 45% of chordomas and 56% of chondrosarcomas recur within five years of surgery. The role of adjuvant therapy is highly debated. No pharmacotherapies have been approved by the FDA for chordomas or chondrosarcomas. The high propensity for recurrence and lack of definitive adjuvant therapy necessitates additional basic science research to identify molecular anomalies associated with recurrent disease...
June 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28639716/expression-of-the-autoantigen-trim33-tif1%C3%AE-in-skin-and-muscle-of-patients-with-dermatomyositis-is-upregulated-together-with-markers-of-cellular-stress
#2
B Scholtissek, S Ferring-Schmitt, J Maier, J Wenzel
Dermatomyositis (DM) is an autoimmune disorder associated with a dysregulation of immune homeostasis of both the innate and adaptive immune system. Earlier data suggested that these two arms of the immune system interconnect in DM. In the current study, we analysed the association of autoantigen expression [adaptive system components: Mi2, transcriptional intermediary factor (TIF)1γ, small ubiquitin-like modifier 1 activating enzyme subunit (SAE)1, melanoma differentiation-associated protein (MDA)5] with markers of cellular stress (innate system components: MxA, p53) in skin and muscle (immunohistology and gene expression data, respectively)...
June 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28637374/facial-emotion-recognition-in-parkinson-s-disease-association-with-age-and-olfaction
#3
S Kalampokini, E Lyros, M Luley, J Schöpe, J Spiegel, J Bürmann, U Dillmann, K Fassbender, M M Unger
OBJECTIVE: The ability to recognize facial emotion expressions has been reported to be impaired in Parkinson's disease (PD), yet previous studies showed inconsistent findings. The aim of this study was to further investigate facial emotion recognition (FER) in PD patients and its association with demographic and clinical parameters (including motor and nonmotor symptoms). METHOD: Thirty-four nondemented PD patients and 24 age- and sex-matched healthy controls (HC) underwent clinical neurological and neuropsychological assessment, standardized olfactory testing with Sniffin' Sticks, and the Ekman 60 Faces Emotion Recognition Test...
June 21, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28627405/the-effects-of-dietary-leucine-on-the-growth-performances-body-composition-metabolic-abilities-and-innate-immune-responses-in-black-carp-mylopharyngodon-piceus
#4
Chenglong Wu, Lian Chen, Zhibin Lu, Jun'e Gao, Yudan Chu, Liang Li, Ming Wang, Geying Zhang, Miaotong Zhang, Jinyun Ye
The present study was focused on the growth, body composition, metabolic abilities and innate immune responses in juvenile black carp Mylopharyngodon piceus fed with six levels of dietary leucine (7.3, 12.4, 16.2, 21.9, 28.3 and 34.5 g kg(-1)) for 9 weeks. Results showed that the highest weight gain (WG) and the lowest feed conversion ratio (FCR) was obtained at 23.5 and 23.9 g kg(-1) dietary leucine using second-order polynomial model, respectively. Adequate dietary leucine content (21.9 and 28.3 g kg(-1)) could significantly up-regulate the expression levels of neuropeptide Y (NPY) and ghrelin (GRL) in the brain of black carp juveniles...
June 13, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28620614/postmenopausal-iron-overload-exacerbated-bone-loss-by-promoting-the-degradation-of-type-i-collagen
#5
Qian Cheng, Xiaofei Zhang, Jun Jiang, Guoyang Zhao, Yin Wang, Youjia Xu, Ximing Xu, Haile Ma
117 postmenopausal women were divided into Normal, Bone loss (BL), and Osteoporosis group. Compared with Normal group (120.96 ± 43.18 μg/L), the serum ferritin (Fer) in BL (223.37 ± 130.27 μg/L) and Osteoporosis group (307.50 ± 161.48 μg/L) was significantly increased (p < 0.05). Fer level was negatively correlated with BMD (p < 0.01). TRACP levels in Osteoporosis group (4.37 ± 1.69 U/L) were significantly higher than Normal group (4.10 ± 1.60 U/L, p < 0.05). ALP levels in Osteoporosis group (112...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28595877/lipoxygenase-inhibitors-protect-acute-lymphoblastic-leukemia-cells-from-ferroptotic-cell-death
#6
Lukas Probst, Jasmin Dächert, Barbara Schenk, Simone Fulda
Ferroptosis has recently been identified as a mode of programmed cell death. However, little is yet known about the signaling mechanisms. Here, we report that lipoxygenases (LOX) contribute to the regulation of RSL3-induced ferroptosis in acute lymphoblastic leukemia (ALL) cells. We show that the glutathione (GSH) peroxidase 4 (GPX4) inhibitor RSL3 triggers lipid peroxidation, production of reactive oxygen species (ROS) and cell death in ALL cells. All these events are impeded in the presence of Ferrostatin-1 (Fer-1), a small-molecule inhibitor of lipid peroxidation...
June 5, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28590513/diagnostic-accuracy-of-increased-urinary-cortisol-cortisone-ratio-to-differentiate-acth-dependent-cushing-s-syndrome
#7
Filippo Ceccato, Laura Trementino, Mattia Barbot, Giorgia Antonelli, Mario Plebani, Luca Denaro, Daniela Regazzo, Federico Rea, Anna Chiara Frigo, Carolina Concettoni, Marco Boscaro, Giorgio Arnaldi, Carla Scaroni
BACKGROUND AND AIM: Differential diagnosis between Cushing's Disease (CD) and Ectopic ACTH Syndrome (EAS) may be a pitfall for endocrinologists. The increasing use in clinical practice of chromatography and mass spectrometry improves the measurement of urinary free cortisol (UFF) and cortisone (UFE). We have recently observed that cortisol to cortisone ratio (FEr) was higher in a small series of EAS; in this paper we collected a larger number of ACTH-dependent CS to study the role of FEr to characterize the source of corticotropin secretion...
June 7, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28577574/activating-transcription-factor-3-promotes-embryo-attachment-via-up-regulation-of-leukemia-inhibitory-factor-in-vitro
#8
Xi Cheng, Jingyu Liu, Huizhi Shan, Lihua Sun, Chenyang Huang, Qiang Yan, Ruiwei Jiang, Lijun Ding, Yue Jiang, Jianjun Zhou, Guijun Yan, Haixiang Sun
BACKGROUND: A receptive endometrium is essential for maternal-embryonic molecular communication during implantation. However, the specific molecular regulatory mechanisms of the endometrial capacity remain poorly understood. Here, we examined activating transcription factor 3 (ATF3) expression in human endometria and the functional effect of ATF3 on embryo attachment in vitro. METHODS: Immunohistochemistry (IHC) was used to assess the ATF3 expression patterns in human endometria...
June 2, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28554844/control-of-cancer-stem-cell-like-population-by-intracellular-target-identification-followed-by-the-treatment-with-peptide-sirna-complex
#9
Jin Sook Suh, Hyun Jung Lee, Hyun Nam, Buem Soo Jo, Dong Woo Lee, Ji-Hye Kim, Jue Yeon Lee, Chong Pyoung Chung, Gene Lee, Yoon Jeong Park
Cancer stem cells (CSCs) are a subpopulation of cancer cells and have been known to create cancer reoccurrence during cancer therapy due to their stem cell-like characteristics. However, exact target to control the CSC has not been fully established. Here, we enriched CD44(High) population of MDA-MB-231 cells by CD44 antibody as a CSC marker. By Phospho Antibody Array, CD44(High) population of MDA-MB-231 cells reveals Feline sarcoma-related tyrosine kinase (FER) protein was highly activated. When FER siRNA and low molecular weight protamine (LMWP) as cell penetrating peptides are applied to this population, cancer migration and colony forming ability are inhibited...
May 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28531319/improved-sperm-kinematics-in-semen-samples-collected-after-2-h-versus-4-7-days-of-ejaculation-abstinence
#10
H Alipour, G Van Der Horst, O B Christiansen, F Dardmeh, N Jørgensen, H I Nielsen, C Hnida
STUDY QUESTION: Does a short abstinence period of only 2 h yield spermatozoa with better motility characteristics than samples collected after 4-7 days? SUMMARY ANSWER: Despite lower semen volume, sperm concentration, total sperm counts and total motile counts, higher percentages of motile spermatozoa with higher velocity and progressiveness were detected in samples obtained after 2 h. WHAT IS KNOWN ALREADY: Most studies that have assessed the effect of abstinence periods on sperm motility parameters in men with a sperm concentration below 15 million/ml have detected a higher percentage of motile spermatozoa in samples obtained after short abstinence periods...
May 22, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28502899/the-expression-of-p450-genes-mediating-fenpropathrin-resistance-is-regulated-by-cncc-and-maf-in-tetranychus-cinnabarinus-boisduval
#11
Li Shi, Mengyao Wang, Yichao Zhang, Guangmao Shen, Haishan Di, Yue Wang, Lin He
Although overexpression of genes encoding detoxification enzymes is a well-known mechanism of pesticide resistance of mites, the regulators involved in this process are still illiterate. Previous studies in our laboratory demonstrated that the overexpression of six P450 genes contributes to fenpropathrin resistance in T. cinnabarinus. In this study, six transcription factor genes that likely regulate the expression of P450 genes were identified and characterized. Quantitative PCR (qPCR) analysis showed that three transcription factor genes were highly expressed in a fenpropathrin-resistant (FeR) strain of T...
May 11, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28499965/effects-of-dietary-dandelion-extracts-on-growth-performance-body-composition-plasma-biochemical-parameters-immune-responses-and-disease-resistance-of-juvenile-golden-pompano-trachinotus-ovatus
#12
Xiaohong Tan, Zhenzhu Sun, Shu Chen, Silin Chen, Zhong Huang, Chuanpeng Zhou, Cuiyun Zou, Qingying Liu, Huaqun Ye, Heizhao Lin, Chaoxia Ye, Anli Wang
The present study was conducted to investigate the effects of dietary dandelion extracts (DE) supplementation on growth performance, feed utilization, body composition, plasma biochemical indices, immune responses, hepatic antioxidant abilities, and resistance to the pathogen Vibrio harveyi in Trachinotus ovatus. A basal diet supplemented with DE at 0, 0.50, 1.00, 2.00, 4.00 and 10.00 g kg(-1) were fed to golden pompano for 8 weeks. The study indicated that dietary supplementation with DE could significantly improve final body weight (FBW), weight gain rate (WGR), specific growth rate (SGR), feed efficiency ratio (FER), feed intake (FI), protein efficiency ratio (PER) and protein deposit rate (PDR) (P < 0...
May 9, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28497246/neural-correlates-of-explicit-versus-implicit-facial-emotion-processing-in-asd
#13
Christina Luckhardt, Anne Kröger, Hannah Cholemkery, Stephan Bender, Christine M Freitag
The underlying neural mechanisms of implicit and explicit facial emotion recognition (FER) were studied in children and adolescents with autism spectrum disorder (ASD) compared to matched typically developing controls (TDC). EEG was obtained from N = 21 ASD and N = 16 TDC. Task performance, visual (P100, N170) and cognitive (late positive potential) event-related-potentials, as well as coherence were compared across groups. TDC showed a task-dependent increase and a stronger lateralization of P100 amplitude during the explicit task and task-dependent modulation of intra-hemispheric coherence in the beta band...
May 11, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28486704/cost-effectiveness-analysis-of-lifestyle-intervention-in-obese-infertile-women
#14
A M van Oers, M A Q Mutsaerts, J M Burggraaff, W K H Kuchenbecker, D A M Perquin, C A M Koks, R van Golde, E M Kaaijk, J M Schierbeek, N F Klijn, Y M van Kasteren, J A Land, B W J Mol, A Hoek, H Groen
STUDY QUESTION: What is the cost-effectiveness of lifestyle intervention preceding infertility treatment in obese infertile women? SUMMARY ANSWER: Lifestyle intervention preceding infertility treatment as compared to prompt infertility treatment in obese infertile women is not a cost-effective strategy in terms of healthy live birth rate within 24 months after randomization, but is more likely to be cost-effective using a longer follow-up period and live birth rate as endpoint...
May 9, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28476487/a-randomized-controlled-trial-comparing-the-efficacy-and-safety-of-two-hmg-preparations-gaining-their-lh-bioactivity-from-different-hcg-sources
#15
Gillian Lockwood, Barbara Cometti, Jeanette Bogstad, Karin Erb, Christian De Geyter, Janos Urbancsek, Silvia Trevisan, Khaled Pocate-Cheriet, Dominique de Ziegler
In this prospective, controlled, randomized, multicentre, non-inferiority study, efficacy and safety of two HMG preparations (Menopur(®)- Ferring and Meriofert®- IBSA Institut Biochimique SA) for ovarian stimulation were compared (270 women undergoing IVF aged between 18 and 39 years; BMI 30 kg/m(2) or less; less than three prior completed assisted reproduction technique cycles). A standard long down-regulation with gonadotrophin-releasing hormone agonist protocol, with HCG triggering was used; primary end-point was total number of oocytes retrieved; attention was paid toovarian hyperstimulation syndrome (OHSS)...
April 20, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28472455/the-long-term-prognosis-for-live-birth-in-couples-initiating-fertility-treatments
#16
S S Malchau, A A Henningsen, A Loft, S Rasmussen, J Forman, A Nyboe Andersen, A Pinborg
STUDY QUESTION: What are the long-term chances of having a child for couples starting fertility treatments and how many conceive with ART, IUI and without treatment? SUMMARY ANSWER: Total 5-year live birthrates were strongly influenced by female age and ranged from 80% in women under 35-26% in women ≥40 years, overall, 14% of couples conceived naturally and one-third of couples starting treatments with intrauterine insemination delivered from that treatment. WHAT IS KNOWN ALREADY: Few studies report success rates in fertility treatments across a couple's complete fertility treatment history, across clinics, evaluating live births after insemination, ART and natural conceptions...
May 4, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28471688/atherogenic-impact-of-lecithin-cholesterol-acyltransferase-and-its-relation-to-cholesterol-esterification-rate-in-hdl-fer-hdl-and-aip-log-tg-hdl-c-biomarkers-the-butterfly-effect
#17
M Dobiášová
The atherogenic impact and functional capacity of LCAT was studied and discussed over a half century. This review aims to clarify the key points that may affect the final decision on whether LCAT is an anti-atherogenic or atherogenic factor. There are three main processes involving the efflux of free cholesterol from peripheral cells, LCAT action in intravascular pool where cholesterol esterification rate is under the control of HDL, LDL and VLDL subpopulations, and finally the destination of newly produced cholesteryl esters either to the catabolism in liver or to a futile cycle with apoB lipoproteins...
May 4, 2017: Physiological Research
https://www.readbyqxmd.com/read/28461335/mechanism-of-ubiquitin-chain-synthesis-employed-by-a-hect-ubiquitin-ligase
#18
Michael E French, Julian L Klosowiak, Aaron Aslanian, Steven I Reed, John R Yates, Tony Hunter
Homologous to E6AP Carboxyl Terminus (HECT) ubiquitin (Ub) ligases (E3s) are a large class of enzymes that bind to their substrates and catalyze ubiquitination through the formation of a Ub thioester intermediate. The mechanisms by which these E3s assemble polyubiquitin chains on their substrates remain poorly defined. We report here that the Nedd4 family HECT E3, WWP1, assembles substrate-linked Ub chains containing K63, K48, and K11 linkages (K63 > K48 > K11). Our results demonstrate that WWP1 catalyzes the formation of Ub chains through a sequential addi-tion mechanism, in which Ub monomers are trans-ferred in a successive fashion to the substrate, and that ubiquitination by WWP1 requires the pres-ence of a low-affinity, noncovalent Ub-binding site within the HECT domain...
May 1, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28459452/targeting-genomic-rearrangements-in-tumor-cells-through-cas9-mediated-insertion-of-a-suicide-gene
#19
Zhang-Hui Chen, Yan P Yu, Ze-Hua Zuo, Joel B Nelson, George K Michalopoulos, Satdatshan Monga, Silvia Liu, George Tseng, Jian-Hua Luo
Specifically targeting genomic rearrangements and mutations in tumor cells remains an elusive goal in cancer therapy. Here, we used Cas9-based genome editing to introduce the gene encoding the prodrug-converting enzyme herpes simplex virus type 1 thymidine kinase (HSV1-tk) into the genomes of cancer cells carrying unique sequences resulting from genome rearrangements. Specifically, we targeted the breakpoints of TMEM135-CCDC67 and MAN2A1-FER fusions in human prostate cancer or hepatocellular carcinoma cells in vitro and in mouse xenografts...
June 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28453688/edlib-a-c-c%C3%A2-library-for-fast-exact-sequence-alignment-using-edit-distance
#20
Martin Šošic, Mile Šikic
Summary: We present Edlib, an open-source C/C ++ library for exact pairwise sequence alignment using edit distance. We compare Edlib to other libraries and show that it is the fastest while not lacking in functionality and can also easily handle very large sequences. Being easy to use, flexible, fast and low on memory usage, we expect it to be easily adopted as a building block for future bioinformatics tools. Availability and Implementation: Source code, installation instructions and test data are freely available for download at https://github...
May 1, 2017: Bioinformatics
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