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https://www.readbyqxmd.com/read/28220679/the-lac-m%C3%A3-gantic-derailment-corporate-regulation-and-neoliberal-sovereignty
#1
David Tyler Dunford
On July 6, 2013, Montreal, Maine, and Atlantic railcar 5017 hauling 72 tanker cars of Bakken crude oil derailed over the town of Lac-Mégantic, Quebec. The town erupted in a fiery inferno as 5,560,000 liters of highly flammable Bakken crude oil exploded over the town, killing 47 people and contaminating 558,000 tons of soil and local waterways. While Montreal, Maine, and Atlantic Rail Chairman Edward Burkhardt initially blamed the derailment on the lone engineer and local firefighters, this study shows how Transport Canada and the rail industry undermined regulatory and safety measures for several years before the derailment...
February 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28188206/insight-into-the-carbon-source-dependent-inducible-veratrylalcohol-and-ferulic-acid-metabolism-in-pseudomonas-putida-csv86
#2
Karishma Mohan, Prashant S Phale
Pseudomonas putida CSV86 degrades lignin-derived metabolic intermediates viz veratrylalcohol, ferulic acid, vanillin and vanillic acid as a sole source of carbon and energy. Strain CSV86 also displayed the ability to degrade lignin sulphonate. Cell respiration, enzyme activity, biotransformation and HPLC analysis suggests that veratyralcohol and ferulic acid are metabolized to vanillic acid by two distinct carbon-source dependent inducible pathways. Vanillic acid was further metabolized to protocatechuic acid and enters the central carbon pathway viaβ-ketoadipate route after ortho ring-cleavage...
February 10, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28154778/surgical-treatment-of-intrahepatic-cholangiocarcinoma-a-retrospective-study-of-104-cases
#3
Xiao-Dong Xun, Qiang Li
OBJECTIVE: To explore the clinicopathological features, surgical treatment techniques, and prognostic risk factors of intrahepatic cholangiocarcinoma (ICC). METHODS: A total of 104 ICC cases were collected from January 2008 to December 2013 at Tianjin Medical University Cancer Institute and Hospital and divided into the hepatic hilum lymphadenectomy (HLL, 21 cases), extended hepatic hilum lymphadenectomy (EHLL, 12 cases), and non-lymphadenectomy (NL, 71 cases) groups...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28137754/efficacy-and-safety-of-follitropin-alfa-lutropin-alfa-in-art-a-randomized-controlled-trial-in-poor-ovarian-responders
#4
P Humaidan, W Chin, D Rogoff, T D'Hooghe, S Longobardi, J Hubbard, J Schertz
STUDY QUESTION: How does the efficacy and safety of a fixed-ratio combination of recombinant human FSH plus recombinant human LH (follitropin alfa plus lutropin alfa; r-hFSH/r-hLH) compare with that of r-hFSH monotherapy for controlled ovarian stimulation (COS) in patients with poor ovarian response (POR)? SUMMARY ANSWER: The primary and secondary efficacy endpoints were comparable between treatment groups and the safety profile of both treatment regimens was favourable...
January 30, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28109190/qtl-mapping-and-candidate-genes-for-resistance-to-fusarium-ear-rot-and-fumonisin-contamination-in-maize
#5
Valentina Maschietto, Cinzia Colombi, Raul Pirona, Giorgio Pea, Francesco Strozzi, Adriano Marocco, Laura Rossini, Alessandra Lanubile
BACKGROUND: Fusarium verticillioides is a common maize pathogen causing ear rot (FER) and contamination of the grains with the fumonisin B1 (FB1) mycotoxin. Resistance to FER and FB1 contamination are quantitative traits, affected by environmental conditions, and completely resistant maize genotypes to the pathogen are so far unknown. In order to uncover genomic regions associated to reduced FER and FB1 contamination and identify molecular markers for assisted selection, an F2:3 population of 188 progenies was developed crossing CO441 (resistant) and CO354 (susceptible) genotypes...
January 21, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28104890/the-receptor-kinase-fer-is-a-ralf-regulated-scaffold-controlling-plant-immune-signaling
#6
Martin Stegmann, Jacqueline Monaghan, Elwira Smakowska-Luzan, Hanna Rovenich, Anita Lehner, Nicholas Holton, Youssef Belkhadir, Cyril Zipfel
In plants, perception of invading pathogens involves cell-surface immune receptor kinases. Here, we report that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RALF) propeptides to inhibit plant immunity. This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced complex formation of the immune receptor kinases EF-TU RECEPTOR (EFR) and FLAGELLIN-SENSING 2 (FLS2) with their co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) to initiate immune signaling...
January 20, 2017: Science
https://www.readbyqxmd.com/read/28104412/features-of-the-broader-autism-phenotype-in-people-with-epilepsy-support-shared-mechanisms-between-epilepsy-and-autism-spectrum-disorder
#7
REVIEW
Annie E Richard, Ingrid E Scheffer, Sarah J Wilson
Richard, A.E., I.E. Scheffer and S.J. Wilson. Features of the broader autism phenotype in people with epilepsy support shared mechanisms between epilepsy and autism spectrum disorder. NEUROSCI BIOBEHAV REV 21(1) XXX-XXX, 2016. To inform on mechanisms underlying the comorbidity of epilepsy and autism spectrum disorder (ASD), we conducted meta-analyses to test whether impaired facial emotion recognition (FER) and theory of mind (ToM), key phenotypic traits of ASD, are more common in people with epilepsy (PWE) than controls...
January 16, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28104335/soil-water-and-nutrient-losses-from-management-alternatives-for-degraded-pasture-in-brazilian-atlantic-rainforest-biome
#8
Paulo Roberto da Rocha Junior, Felipe Vaz Andrade, Eduardo de Sá Mendonça, Guilherme Kangussú Donagemma, Raphael Bragança Alves Fernandes, Rabin Bhattharai, Prasanta Kumar Kalita
The objective of this study was to evaluate sediment, water and nutrient losses from different pasture managements in the Atlantic Rainforest biome. A field study was carried out in Alegre Espiríto Santo, Brazil, on a Xanthic Ferralsol cultivated with braquiaria (Brachiaria brizantha). The six pasture managements studied were: control (CON), chisel (CHI), fertilizer (FER), burned (BUR), plowing and harrowing (PH), and integrated crop-livestock (iCL). Runoff and sediment samples were collected and analyzed for calcium (Ca), magnesium (Mg), potassium (K), phosphorus (P) and organic carbon contents...
January 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28074978/-effect-of-meal-frequency-and-carbohydrate-intake-on-the-metabolic-control-of-patients-with-type-2-diabetes-mellitus
#9
Tamara Leiva, Karen Basfi-Fer, Pamela Rojas, Fernando Carrasco, Manuel Ruz O
BACKGROUND: Increasing meal frequency is commonly used in the clinical practice as part of the nutritional treatment of patients with type 2 Diabetes Mellitus (DM2), although its effect on metabolic control parameters is controversial. AIM: To evaluate the association of energy intake, meal frequency, and amount of carbohydrates with fasting plasma glucose and glycosylated hemoglobin in a group of patients with DM2 without insulin therapy. MATERIAL AND METHODS: Dietary intake was evaluated in 60 subjects with DM2 through three-day food records...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28060498/1-8-cineole-in-french-red-wines-evidence-for-a-contribution-related-to-its-various-origins
#10
Xavier Poitou, Cécile Thibon, Philippe Darriet
The aromatic descriptor "green", reflecting grape unripeness in French red wines, is frequently associated with the levels of 3-alkyl-2-methoxypyrazines, particularly 3-isobutyl-2-methoxypyrazine (IBMP), which has bell pepper nuances. Nevertheless, not all green aromatic expressions in red wines correlate with 3-alkyl-2-methoxypyrazine concentrations. This study considered sensory and chemical approaches using Cabernet Sauvignon wines obtained from grapes harvested at one-month intervals during the 2014 and 2015 vintages to investigate other volatile odoriferous compounds...
January 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28058833/de-novo-discovery-of-hdabco-bf4-molecular-ferroelectric-thin-film-for-nonvolatile-low-voltage-memories
#11
Ping-Ping Shi, Yuan-Yuan Tang, Peng-Fei Li, Heng-Yun Ye, Ren-Gen Xiong
To date, the field of ferroelectric random access memories (FeRAMs) is mainly dominated by inorganic ferroelectric thin films like Pb(Zr,Ti)O3, which suffer from the issues of environmental harmfulness, high processing temperatures, and high fabrication costs. In these respects, molecular ferroelectric thin films are particularly advantageous and thus become promising alternatives to the conventional inorganic ones. For the prospect of FeRAMs applications, they should fulfill the requirements of effective polarization switching and low-voltage, high-speed operation...
January 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28024224/facial-emotion-recognition-theory-of-mind-and-the-role-of-facial-mimicry-in-depression
#12
Julia C Zwick, Larissa Wolkenstein
BACKGROUND: This study examined whether acutely (aMDD) and remitted depressed patients (rMDD) show deficits in the two aspects of social cognition - facial emotion recognition (FER) and reasoning - when using ecologically valid material. Furthermore, we examined whether reduced facial mimicry mediates the association between depressive symptoms and FER, and whether FER deficits and reasoning deficits are associated. METHOD: In 42 aMDD, 43 rMDD, and 39 healthy controls (HC) FER was assessed using stimuli from the Amsterdam Dynamic Facial Expression Set, reasoning by the Movie for the Assessment of Social Cognition...
December 19, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28007789/reproductive-hormones-of-icsi-conceived-young-adult-men-the-first-results
#13
Florence Belva, Mathieu Roelants, Jean De Schepper, André Van Steirteghem, Herman Tournaye, Maryse Bonduelle
STUDY QUESTION: Are reproductive hormone levels (FSH, LH, inhibin B and testosterone) in male offspring conceived by ICSI because of male infertility comparable with those from peers born after spontaneous conception? SUMMARY ANSWER: In this cohort of 54 young men conceived by ICSI because of male-factor infertility, mean and median reproductive hormone levels were found to be comparable with results from spontaneously conceived peers, but ICSI-conceived men were more likely to have low inhibin B (<10th percentile) and high FSH (>90th percentile) levels...
December 21, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27999118/effect-of-pretreatment-with-oral-contraceptives-and-progestins-on-ivf-outcomes-in-women-with-polycystic-ovary-syndrome
#14
Daimin Wei, Yuhua Shi, Jing Li, Ze Wang, Lin Zhang, Yun Sun, Hong Zhou, Yuping Xu, Chunxiang Wu, Ling Liu, Qiongfang Wu, Lili Zhuang, Yanzhi Du, Weiping Li, Heping Zhang, Richard S Legro, Zi-Jiang Chen
STUDY QUESTION: Do oral contraceptives (OCs) and progestins impact live birth rate of IVF when used for cycle scheduling in women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: OCs used for scheduling IVF cycle were associated with lowered rates of pregnancy and live birth after fresh embryo transfer, whereas progestins used for this purpose yield higher rates of pregnancy and live birth than OCs. WHAT IS KNOWN ALREADY: Due to oligo-menorrhea in PCOS, OCs and progestin are extensively used to schedule the start of an IVF cycle in women with PCOS...
February 2017: Human Reproduction
https://www.readbyqxmd.com/read/27997103/kinetic-isotope-effects-and-transition-state-structure-for-human-phenylethanolamine-n-methyltransferase
#15
Christopher F Stratton, Myles B Poulin, Quan Du, Vern L Schramm
Phenylethanolamine N-methyltransferase (PNMT) catalyzes the S-adenosyl-l-methionine (SAM)-dependent conversion of norepinephrine to epinephrine. Epinephrine has been associated with critical processes in humans including the control of respiration and blood pressure. Additionally, PNMT activity has been suggested to play a role in hypertension and Alzheimer's disease. In the current study, labeled SAM substrates were used to measure primary methyl-(14)C and (36)S and secondary methyl-(3)H, 5'-(3)H, and 5'-(14)C intrinsic kinetic isotope effects for human PNMT...
December 28, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/27976501/pore-topology-effects-in-positron-annihilation-spectroscopy-of-zeolites
#16
Asier Zubiaga, Robbie Warringham, Sharon Mitchell, Lars Gerchow, David Cooke, Paolo Crivelli, Javier Pérez-Ramírez
Positron annihilation spectroscopy (PAS) is a powerful method to study the size and connectivity of pores in zeolites. The lifetime of positronium within the host material is commonly described by the Tao-Eldrup model. However, one of its largest limitations arises from the simple geometries considered for the shape of the pores, which cannot describe accurately the complex topologies in zeolites. Here, an atomic model that combines the Tao potential with the crystallographic structure is introduced to calculate the distribution and lifetime of Ps intrinsic to a given framework...
December 14, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27957818/optimal-pharmacological-treatment-and-adherence-to-medication-in-secondary-prevention-of-cardiovascular-events-in-spain-results-from-the-caps-study
#17
Alberto Cordero, Luis Rodriguez Padial, Alberto Batalla, Luis López Barreiro, Francisco Torres Calvo, Jose M Castellano, Emilio Ruiz, Vicente Bertomeu-Martínez
INTRODUCTION: Despite the large amount of evidence supporting the use of antiplatelet agents, beta-blockers, angiotensin antagonists, and lipid-lowering statins in patients with stable coronary artery disease, several studies have documented underprescription of optimal medical treatment (OMT) in Spain. AIMS: The present study aims to describe the current trend of pharmacological prescription in secondary prevention treatment for cardiovascular diseases (CVD) in a Spanish cohort...
December 13, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27943135/degarelix-for-treating-advanced-hormone-dependent-prostate-cancer-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#18
REVIEW
Lesley Uttley, Sophie Whyte, Timothy Gomersall, Shijie Ren, Ruth Wong, Duncan Chambers, Paul Tappenden
As part of its Single Technology Appraisal Process, the National Institute for Health and Care Excellence (NICE) invited the manufacturer of degarelix (Ferring Pharmaceuticals) to submit evidence for the clinical and cost effectiveness of degarelix for the treatment of advanced hormone-dependent prostate cancer. The School of Health and Related Research Technology Appraisal Group at the University of Sheffield was commissioned to act as the independent Evidence Review Group (ERG). The ERG produced a critical review of the evidence contained within the company's submission to NICE...
December 10, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27930296/receptor-kinase-complex-transmits-ralf-peptide-signal-to-inhibit-root-growth-in-arabidopsis
#19
Changqing Du, Xiushan Li, Jia Chen, Weijun Chen, Bin Li, Chiyu Li, Long Wang, Jianglin Li, Xiaoying Zhao, Jianzhong Lin, Xuanming Liu, Sheng Luan, Feng Yu
A number of hormones work together to control plant cell growth. Rapid Alkalinization Factor 1 (RALF1), a plant-derived small regulatory peptide, inhibits cell elongation through suppression of rhizosphere acidification in plants. Although a receptor-like kinase, FERONIA (FER), has been shown to act as a receptor for RALF1, the signaling mechanism remains unknown. In this study, we identified a receptor-like cytoplasmic kinase (RPM1-induced protein kinase, RIPK), a plasma membrane-associated member of the RLCK-VII subfamily, that is recruited to the receptor complex through interacting with FER in response to RALF1...
December 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27920089/world-endometriosis-society-consensus-on-the-classification-of-endometriosis
#20
Neil P Johnson, Lone Hummelshoj, G David Adamson, Jörg Keckstein, Hugh S Taylor, Mauricio S Abrao, Deborah Bush, Ludwig Kiesel, Rulla Tamimi, Kathy L Sharpe-Timms, Luk Rombauts, Linda C Giudice
STUDY QUESTION: What is the global consensus on the classification of endometriosis that considers the views of women with endometriosis? SUMMARY ANSWER: We have produced an international consensus statement on the classification of endometriosis through systematic appraisal of evidence and a consensus process that included representatives of national and international, medical and non-medical societies, patient organizations, and companies with an interest in endometriosis...
February 2017: Human Reproduction
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