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https://www.readbyqxmd.com/read/29776970/the-e3-ubiquitin-ligase-mib-1-is-necessary-to-form-the-nuclear-halo-in-caenorhabditis-elegans-sperm
#1
Leslie A Herrera, Daniel A Starr
Unlike the classical nuclear envelope with two membranes found in other eukaryotic cells, most nematode sperm nuclei are not encapsulated by membranes. Instead, they are surrounded by a nuclear halo of unknown composition. How the halo is formed and regulated is unknown. We used forward genetics to identify molecular lesions behind three classical fer (fertilization defective) mutations that disrupt the ultrastructure of the Caenorhabditis elegans sperm nuclear halo. We found fer-2 and fer-4 alleles to be nonsense mutations in mib-1...
May 18, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29767311/developing-a-non-point-source-p-loss-indicator-in-r-and-its-parameter-uncertainty-assessment-using-glue-a-case-study-in-northern-china
#2
Jingjun Su, Xinzhong Du, Xuyong Li
Uncertainty analysis is an important prerequisite for model application. However, the existing phosphorus (P) loss indexes or indicators were rarely evaluated. This study applied generalized likelihood uncertainty estimation (GLUE) method to assess the uncertainty of parameters and modeling outputs of a non-point source (NPS) P indicator constructed in R language. And the influences of subjective choices of likelihood formulation and acceptability threshold of GLUE on model outputs were also detected. The results indicated the following...
May 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29757413/evaluation-of-iron-stores-by-zinc-protoporphyrin-analysis-in-blood-donors
#3
Richard R Gammon, Tania Kozel, Patrick Morel, Christopher Kendrick
Background: Zinc protoporphyrin (ZPP) testing has been studied previously as a substitute for ferritin (fer) testing of blood donors in determining iron stores. Objective: To determine whether ZPP testing could be performed using specimens collected via the capillary (cap) finger-stick (FS) method, similar to predonation hemoglobin (HB) testing. Also, we evaluated the correlation among FS HB, venous (ven) ZZP, FS ZPP, and ven fer levels as predictors of iron depletion...
May 11, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29754581/the-clinical-characteristics-and-therapy-response-of-patients-with-acquired-pure-red-cell-aplasia
#4
Rong Fu, Tian Zhang, Bingnan Liu, Jia Song, Guojin Wang, Lijuan Li, Huaquan Wang, Limin Xing, Yuhong Wu, Jing Guan, Zonghong Shao
OBJECTIVE: To summarize the clinical characteristics of acquired pure red cell aplasia (PRCA) patients diagnosed in our hospital in the last 10 years. METHOD: The clinical features, immune state and treatment response of acquired PRCA patients diagnosed in our hospital from January 2007 to January 2017 were retrospectively analyzed. RESULTS: The results showed that thymoma (13.21%) and parvovirus B19 (11.32%) were the most common causes for secondary PRCA...
May 12, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29753143/the-function-of-eriocheir-sinensis-transferrin-and-iron-in-spiroplasma-eriocheiris-infection
#5
Xuechuan Xu, Yuhan Liu, Mengyue Tang, Yuye Yan, Wei Gu, Wen Wang, Qingguo Meng
Transferrin, a member of the iron binding superfamily protein, plays an extremely important role in the transport of iron in the biological process of cells. The result of preliminary proteomic study on E. sinensis hemocytes infected Spiroplasma eriocheiris showed the expression of transferrin (EsTF) and ferrin (EsFe) significantly changed. In addition, other reports have confirmed that transferrin, ferritin and iron are involved in the immune response of hosts. In order to validate the immune function of EsTF, the whole length of EsTF was successfully amplified by the gene cloning and RACE technique...
May 9, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29752642/can-short-term-pasture-management-increase-c-balance-in-the-atlantic-rainforest
#6
Paulo Roberto da Rocha Junior, Felipe Vaz Andrade, Lucas Santos Satiro, Guilherme Kangussú Donagemma, Eduardo de Sá Mendonça
Few studies have shown the importance of different pasture management practices on C storage and the reduction of CO2 -C emissions in tropical conditions. The objective of the present study was to determine short-term changes in C pools and C balance from different pasture management practices established in the Atlantic Rainforest. A field study was carried out in Alegre, ES, Brazil from September 2013 to August 2014 to investigate the first-year effect of pasture management practices on a Udult clayey soil...
May 11, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29727165/white-light-emitting-and-enhanced-color-stability-in-a-single-component-host
#7
Junhao Li, Qiongyun Liang, Jun-Yu Hong, Jing Yan, Leonid Dolgov, Yuying Meng, Yiqin Xu, Jianxin Shi, Mingmei Wu
Eu3+ ion can be effectively sensitized by Ce3+ ion through an energy transfer chain of Ce3+-(Tb3+)n-Eu3+, which has contributed to the development of white-light emitting diodes (WLEDs) as it can favour more efficient red phosphors. However, simply serving for WLEDs as one of the multi-components, the design of the Ce3+-(Tb3+)n-Eu3+ energy transfer is undoubtedly underused. Theoritically, white light can be achieved with extra blue and green emissions released from Ce3+ and Tb3+. Herein, the design of the white light based on these three multi-color luminescence centers has been real-ized in GdBO3...
May 4, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29700898/development-and-stability-of-a-heat-stable-formulation-of-carbetocin-for-the-prevention-of-postpartum-haemorrhage-for-use-in-low-and-middle-income-countries
#8
Mattias Malm, Ingbritt Madsen, Johan Kjellström
Postpartum haemorrhage is a leading cause of maternal death worldwide. Oxytocin, currently the drug of choice for prevention of PPH, requires constant refrigeration. In pursuit of an alternative medicine, Ferring Pharmaceuticals have developed a heat-stable formulation of carbetocin, an oxytocin analogue. This study aimed to define that formulation, and to investigate its stability under ICH climate zone IV conditions (30°C/75% relative humidity) for at least 3 years and at extreme temperatures, such as 60°C, for shorter periods of time...
April 27, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29664504/contribution-of-the-use-of-basic-telemedicine-tools-to-the-care-of-children-and-adolescents-with-juvenile-idiopathic-arthritis-at-the-puerto-montt-hospital-chile
#9
A S Strickler, J Palma, R Charris, T Candia, M Grez, B González, A King, V Rivera
Children and adolescents with rheumatologic diseases require specialized and comprehensive care, but pediatric rheumatologists and immunologists are concentrated in hospitals with specific, high-cost and modern technology. Considering that some patients with juvenile idiopathic arthritis (JIA) live in rural, remote and limited accessibility areas, the use of Telemedicine (TM) can optimize diag nosis, follow-up and prognosis. OBJECTIVE: Reporting 10 years of experience of a mixed care model: face-to-face and distance, using basic TM; the institutional impact, advantages, disadvantages and acceptance informed by parents and patients...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29660984/chemically-induced-degradation-of-anaplastic-lymphoma-kinase-alk
#10
Chelsea E Powell, Yang Gao, Li Tan, Katherine A Donovan, Radosław P Nowak, Amanda Loehr, Magda Bahcall, Eric S Fischer, Pasi A Janne, Rani E George, Nathanael S Gray
We present the development of the first small molecule degraders that can induce anaplastic lymphoma kinase (ALK) degradation, including in non-small-cell lung cancer (NSCLC), anaplastic large-cell lymphoma (ALCL), and neuroblastoma (NB) cell lines. These degraders were developed through conjugation of known pyrimidine-based ALK inhibitors, TAE684 or LDK378, and the cereblon ligand pomalidomide. We demonstrate that in some cell types degrader potency is compromised by expression of drug transporter ABCB1. In addition, proteomic profiling demonstrated that these compounds also promote the degradation of additional kinases including PTK2 (FAK), Aurora A, FER, and RPS6KA1 (RSK1)...
April 16, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29627624/cryopreservation-and-egg-yolk-medium-alter-the-proteome-of-ram-spermatozoa
#11
T Pini, J P Rickard, T Leahy, B Crossett, X Druart, S P de Graaf
Cryopreservation causes significant lethal and sub-lethal damage to spermatozoa. In order to improve freezing outcomes, a comprehensive understanding of sub-lethal damage is required. Cryopreservation induced changes to sperm proteins have been investigated in several species, but few have employed currently available state of the art, data independent acquisition mass spectrometry (MS) methods. We used the SWATH LC-MS method to quantitatively profile proteomic changes to ram spermatozoa following exposure to egg yolk and cryopreservation...
April 5, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29600753/bacterial-transferase-mray-a-source-of-inspiration-towards-new-antibiotics
#12
Mickael J Fer, Laurent Le Corre, Nicolas Pietrancosta, Nathalie Evrard-Todeschi, Samir Olatunji, Ahmed Bouhss, Sandrine Calvet-Vitale, Christine Gravier-Pelletier
The bacterial resistance to antibiotics constitutes more than ever a severe public health problem. The enzymes involved in bacterial peptidoglycan biosynthesis are pertinent targets for developing new antibiotics, notably the MraY transferase that is not targeted by any marketed drug. Many research groups are currently working on the study or the inhibition of this enzyme. After a concise overview of the role, mechanism and inhibition of MraY, the structure-activity relationships of 5'-triazole-containing aminoribosyluridine inhibitors we previously synthetized will be presented...
March 29, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29573077/electronic-communication-between-two-10-cycloparaphenylenes-and-bisazafullerene-c59n-2-induced-by-cooperative-complexation
#13
Jérémy Rio, Sebastian Beeck, Georgios Rotas, Sebastian Ahles, Denis Jacquemin, Nikos Tagmatarchis, Chris Ewels, Hermann Andreas Wegner
The complex of [10]cycloparaphenylene ([10]CPP) with bisazafullerene (C59N)2 is investigated experimentally and computationally. Two [10]CPP rings are bound to the dimeric azafullerene giving [10]CPP⊃(C59N)2⊂[10]CPP. Photophysical and redox properties support an electronic interaction between the com-ponents especially with the second [10]CPP bound. Unlike [10]CPP⊃C60, where there is negligible electronic communication bet¬ween the two species, upon photoexcitation a partial charge trans¬fer phenomenon is revealed between [10]CPP and (C59N)2 reminiscent of CPP encapsulated metallofullerenes...
March 23, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29551679/enpp2-protects-cardiomyocytes-from-erastin-induced-ferroptosis
#14
Yu-Ting Bai, Rong Chang, Hua Wang, Feng-Jun Xiao, Ri-Li Ge, Li-Sheng Wang
Ferroptosis is an iron- and oxidative-dependent form of regulated cell death and may play important roles in maintaining myocardium homeostasis and pathology of cardiovascular diseases. Currently, the regulatory roles of lipid signals in regulating cardiomyocytes ferroptosis has not been explored. In this study, we show that ENPP2, as a lipid kinase involved in lipid metabolism, protects against erastin-induced ferroptosis in cardiomyocytes. The classical ferroptosis inducer erastin remarkably inhibits the growth which could be rescued by the small molecule Fer-1 in H9c2 cells...
March 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29546361/single-embryo-transfer-by-day-3-time-lapse-selection-versus-day-5-conventional-morphological-selection-a-randomized-open-label-non-inferiority-trial
#15
Lanlin Yang, Sufen Cai, Shuoping Zhang, Xiangyi Kong, Yifan Gu, Changfu Lu, Jing Dai, Fei Gong, Guangxiu Lu, Ge Lin
STUDY QUESTION: Does single cleavage-stage (Day 3) embryo transfer using a time-lapse (TL) hierarchical classification model achieve comparable ongoing pregnancy rates (OPR) to single blastocyst (Day 5) transfer by conventional morphological (CM) selection? SUMMARY ANSWER: Day 3 single embryo transfer (SET) with a hierarchical classification model had a significantly lower OPR compared with Day 5 SET with CM selection. WHAT IS KNOWN ALREADY: Cleavage-stage SET is an alternative to blastocyst SET...
March 13, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29545370/pdgfr%C3%AE-translocates-to-the-nucleus-and-regulates-chromatin-remodeling-via-tata-element-modifying-factor-1
#16
Natalia Papadopoulos, Johan Lennartsson, Carl-Henrik Heldin
Translocation of full-length or fragments of receptors to the nucleus has been reported for several tyrosine kinase receptors. In this paper, we show that a fraction of full-length cell surface platelet-derived growth factor (PDGF) receptor β (PDGFRβ) accumulates in the nucleus at the chromatin and the nuclear matrix after ligand stimulation. Nuclear translocation of PDGFRβ was dependent on PDGF-BB-induced receptor dimerization, clathrin-mediated endocytosis, β-importin, and intact Golgi, occurring in both normal and cancer cells...
March 15, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29542009/a-comparison-between-rheological-properties-of-intra-articular-hyaluronic-acid-preparations-and-reported-human-synovial-fluid
#17
Mat Nicholls, Ajay Manjoo, Peter Shaw, Faizan Niazi, Jeffrey Rosen
INTRODUCTION: This study aims to compare the properties of currently available intra-articular hyaluronate (IA-HA) products widely available in the USA to those of healthy knee synovial fluid with respect to their bulk rheological properties. We hypothesize that products would have differing rheological properties, with some more closely resembling the properties and physiological aspects of healthy joint fluid HA. METHODS: We obtained reported HA product molecular weights, as well as measurements of the presence of cross-linking, zero shear rate viscosity, shear thinning ratio, and crossover frequency for the following IA-HA products available in the USA: Euflexxa® , Orthovisc® , Supartz® , Monovisc® , Synvisc® , Synvisc-One® , Gel-One® , and Hyalgan® ...
March 14, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29540831/fes-related-tyrosine-kinase-activates-the-insulin-like-growth-factor-1-receptor-at-sites-of-cell-adhesion
#18
Joanna Stanicka, Leonie Rieger, Sandra O'Shea, Orla Cox, Michael Coleman, Ciara O'Flanagan, Barbara Addario, Nuala McCabe, Richard Kennedy, Rosemary O'Connor
IGF-1 receptor (IGF-1R) and integrin cooperative signaling promotes cancer cell survival, proliferation, and motility, but whether this influences cancer progression and therapy responses is largely unknown. Here we investigated the non-receptor tyrosine adhesion kinase FES-related (FER), following its identification as a potential mediator of sensitivity to IGF-1R kinase inhibition in a functional siRNA screen. We found that FER and the IGF-1R co-locate in cells and can be co-immunoprecipitated. Ectopic FER expression strongly enhanced IGF-1R expression and phosphorylation on tyrosines 950 and 1131...
March 15, 2018: Oncogene
https://www.readbyqxmd.com/read/29538679/advanced-glycation-end-products-alter-steroidogenic-gene-expression-by-granulosa-cells-an-effect-partially-reversible-by-vitamin-d
#19
Z Merhi, E Buyuk, M J Cipolla
STUDY QUESTION: Does vitamin D attenuate the adverse effects of advanced glycation end products (AGEs) on steroidogenesis by human granulosa cells (GCs)? SUMMARY ANSWER: AGEs alter the expression of genes important in steroidogenesis while 1,25-dihydroxyvitamin D3 (vit D3) in vitro attenuates some of the actions of AGEs on steroidogenic gene expression, possibly by downregulating the expression of the pro-inflammatory cell membrane receptor for AGEs (RAGE). WHAT IS KNOWN ALREADY: Vitamin D attenuates the pro-inflammatory effects of AGEs in non-ovarian tissues...
March 12, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29530004/effect-of-infant-feeding-practices-on-iron-status-in-a-cohort-study-of-bolivian-infants
#20
Rachel M Burke, Paulina A Rebolledo, Anna M Aceituno, Rita Revollo, Volga Iñiguez, Mitchel Klein, Carolyn Drews-Botsch, Juan S Leon, Parminder S Suchdev
BACKGROUND: Iron deficiency (ID) is the most common micronutrient deficiency worldwide, with potentially severe consequences on child neurodevelopment. Though exclusive breastfeeding (EBF) is recommended for 6 months, breast milk has low iron content. This study aimed to estimate the effect of the length of EBF on iron status at 6 - 8 months of age among a cohort of Bolivian infants. METHODS: Mother-infant pairs were recruited from 2 hospitals in El Alto, Bolivia, and followed from one through 6 - 8 months of age...
March 12, 2018: BMC Pediatrics
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