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ischemia and endoplasmic reticulum

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https://www.readbyqxmd.com/read/29774449/cellular-and-subcellular-localization-of-endoplasmic-reticulum-chaperone-grp78-following-transient-focal-cerebral-ischemia-in-rats
#1
Xuyan Jin, Dong Kyu Kim, Tae-Ryong Riew, Hong Lim Kim, Mun-Yong Lee
The 78-kDa glucose-regulated protein (GRP78), a chaperone protein located in the endoplasmic reticulum (ER), has been reported to have neuroprotective effects in the injured central nervous system. Our aim was to examine the expression profiles and subcellular distributions of GRP78 and its association with the neuroglial reaction in the rat striatum after transient, focal cerebral ischemia. In sham-operated rats, constitutive, specific immunoreactivity for GRP78 was almost exclusively localized to the rough ER of striatal neurons, with none in the resting, ramified microglia or astrocytes...
May 17, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29771714/remifentanil-induces-cardio-protection-against-ischemia-reperfusion-injury-by-inhibiting-endoplasmic-reticulum-stress-through-the-maintenance-of-zinc-homeostasis
#2
Mingwei Sheng, Ge Zhang, Jiannan Wang, Qing Yang, Huanhuan Zhao, Xinxin Cheng, Zhelong Xu
BACKGROUND: Although it is well known that remifentanil (Rem) elicits cardiac protection against ischemia/reperfusion (I/R) injury, the underlying mechanism remains unclear. This study tested if Rem can protect the heart from I/R injury by inhibiting endoplasmic reticulum (ER) stress through the maintenance of zinc (Zn) homeostasis. METHODS: Isolated rat hearts were subjected to 30 minutes of regional ischemia followed by 2 hours of reperfusion. Rem was given by 3 consecutive 5-minute infusions, and each infusion was followed by a 5-minute drug-free perfusion before ischemia...
May 15, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29771603/negative-feedback-loop-of-autophagy-and-endoplasmic-reticulum-stress-in-rapamycin-protection-against-renal-ischemia-reperfusion-injury-during-initial-reperfusion-phase
#3
Xinyuan Li, Gongmin Zhu, Xin Gou, Weiyang He, Hubin Yin, Xiaoyu Yang, Jie Li
Rapamycin, an immunosuppressant, is widely used in patients with kidney transplant. However, the therapeutic effects of rapamycin remain controversial. Additionally, previous studies have revealed deleterious effects of rapamycin predominantly when administered for ≥24 h. Few studies, however, have focused on the short-term effects of rapamycin administered only during the initial reperfusion phase. As such, we designed this study to explore the potential effects and mechanisms of rapamycin under a specific therapeutic regimen in which rapamycin is mixed in the perfusate during the initial reperfusion phase (within 24 h)...
May 17, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29761825/zinc-mitigates-renal-ischemia-reperfusion-injury-in-rats-by-modulating-oxidative-stress-endoplasmic-reticulum-stress-and-autophagy
#4
Najet Hadj Abdallah, Anna Baulies, Ahlem Bouhlel, Mohamed Bejaoui, Mohamed A Zaouali, Safa Ben Mimouna, Imed Messaoudi, José C Fernandez-Checa, Carmen García Ruiz, Hassen Ben Abdennebi
Oxidative stress is a major factor involved in the pathogenesis of renal ischemia/reperfusion (I/R). Exogenous zinc (Zn) was suggested as a potent antioxidant; however, the mechanism by which it strengthens the organ resistance against the effects of reactive oxygen species (ROS) is not yet investigated. The present study aims to determine whether acute zinc chloride (ZnCl2 ) administration could attenuate endoplasmic reticulum (ER) stress, autophagy, and inflammation after renal I/R. Rats were subjected to either sham operation (Sham group, n = 6), or 1 hr of bilateral ischemia followed by 2 hr of reperfusion (I/R groups, n = 6), or they received ZnCl2 orally 24 hr and 30 min before ischemia (ZnCl2 group, n = 6)...
May 15, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29750876/evaluation-of-molecular-changes-of-distal-organs-after-small-bowel-transplantation-experimental-study
#5
P Urban, M Rabajdová, Š Feterik, G Bódy, T Granda, M Mareková, J Veselá
The ischemia and reperfusion of a jejunal graft during transplantation triggers the stress of endoplasmic reticulum; thus inducing the synthesis of pro-inflammatory cytokines. Spreading of these signals stimulate immunological reactions in distal tissues i.e. lung, liver and spleen. The aim of this study was to detect the molecular changes in liver and spleen induced by transplanted jejunal graft with one or six hours of reperfusion (group Tx1 and Tx6). Analysis of gene expression changes of inflammatory mediators (TNFalpha, IL-10) and specific chaperones (Gadd153, Grp78) derived from endoplasmic reticulum (ER) was done and compared to control group...
May 10, 2018: Physiological Research
https://www.readbyqxmd.com/read/29733120/thymoquinone-protects-rat-liver-after-partial-hepatectomy-under-ischemia-reperfusion-through-oxidative-stress-and-endoplasmic-reticulum-stress-prevention
#6
Ahlem Bouhlel, Mohamed Bejaoui, Ismail Ben Mosbah, Najet Hadj Abdallah, Catherine Ribault, Roselyne Viel, Hassen Hentati, Anne Corlu, Hassen Ben Abdennebi
Ischemia reperfusion (I/R) is associated with liver injury and impaired regeneration during partial hepatectomy (PH). The aim of this study was to investigate the effect of thymoquinone (TQ), the active compound of essential oil obtained from Nigella sativa seeds, on rat liver after PH. Male Wistar rats were equally divided into four groups (n=6) receiving an oral administration of either vehicle solution (Sham and PH groups) or TQ at 30 mg/kg (TQ and TQ+PH groups) for ten consecutive days. Then, rats underwent PH (70%) with 60 min of ischemia followed by 24h of reperfusion (PH and TQ+PH groups)...
May 7, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29728112/connexin32-plays-a-crucial-role-in-ros-mediated-endoplasmic-reticulum-stress-apoptosis-signaling-pathway-in-ischemia-reperfusion-induced-acute-kidney-injury
#7
Yu Gu, Fei Huang, Yanling Wang, Chaojin Chen, Shan Wu, Shaoli Zhou, Ziqing Hei, Dongdong Yuan
BACKGROUND: Ischemia-reperfusion (I/R)-induced acute kidney injury (AKI) not only prolongs the length of hospital stay, but also seriously affects the patient's survival rate. Although our previous investigation has verified that reactive oxygen species (ROS) transferred through gap junction composed of connexin32 (Cx32) contributed to AKI, its underlying mechanisms were not fully understood and viable preventive or therapeutic regimens were still lacking. Among various mechanisms involved in organs I/R-induced injuries, endoplasmic reticulum stress (ERS)-related apoptosis is currently considered to be an important participant...
May 4, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29705352/apigenin-7-o-%C3%AE-d-6%C3%A2-p-coumaroyl-glucopyranoside-pretreatment-attenuates-myocardial-ischemia-reperfusion-injury-via-activating-ampk-signaling
#8
Yingda Feng, Yunyang Lu, Dan Liu, Wei Zhang, Juntian Liu, Haifeng Tang, Yanrong Zhu
AIMS: Apigenin-7-O-β-d-(-6″-p-coumaroyl)-glucopyranoside (APG) was considered as the major active compound derived from Clematis tangutica. Though we have demonstrated that APG exerts cardioprotective effects, the mechanism of APG-mediated cardioprotection remains largely unknown. Numerous studies indicate that endoplasmic reticulum stress (ERS) is a vital injury factor in myocardial ischemia reperfusion (MI/R). In this study, we mainly investigated whether modulation of the ERS and AMPK were involved in the cardioprotective action of APG during MI/R injury...
April 26, 2018: Life Sciences
https://www.readbyqxmd.com/read/29700294/reduction-of-endoplasmic-reticulum-stress-improves-angiogenic-progenitor-cell-function-in-a-mouse-model-of-type-1-diabetes
#9
Maulasri Bhatta, Krishna Chatpar, Zihua Hu, Joshua J Wang, Sarah X Zhang
Persistent vascular injury and degeneration in diabetes are attributed in part to defective reparatory function of angiogenic cells. Our recent work implicates endoplasmic reticulum (ER) stress in high-glucose-induced bone marrow (BM) progenitor dysfunction. Herein, we investigated the in vivo role of ER stress in angiogenic abnormalities of streptozotocin-induced diabetic mice. Our data demonstrate that ER stress markers and inflammatory gene expression in BM mononuclear cells and hematopoietic progenitor cells increase dynamically with disease progression...
April 27, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29695649/stf-083010-an-inhibitor-of-xbp1-splicing-attenuates-acute-renal-failure-in-rats-by-suppressing-endoplasmic-reticulum-stress-induced-apoptosis-and-inflammation
#10
Lei Liu, Lu Xu, Shaoqing Zhang, Dong Wang, Guoxia Dong, Hanwen Chen, Xinjian Li, Chi Shu, Rong Wang
Endoplasmic reticulum (ER) stress is one of the driving forces of ischemia/reperfusion (IR)-induced acute renal failure (ARF). STF-083010, an inhibitor of the endonuclease activity of inositol-requiring enzyme-1 (IRE1), has the potential to block the initiation of a prolonged unfolded protein response (UPR) that is stimulated by ER stress and alleviates the impairments due to ER stress. In the current study, it was hypothesized that STF-083010 was capable of ameliorating ER stress-related damages in IR-induced ARF...
April 25, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29693708/diazoxide-inhibits-of-er-stress%C3%A2-mediated-apoptosis-during-oxygen%C3%A2-glucose-deprivation-in-vitro-and-cerebral-ischemia%C3%A2-reperfusion-in-vivo
#11
Xiaofeng Lei, Lijian Lei, Zhiqing Zhang, Yan Cheng
Neuroprotective strategies using diazoxide (DZX) have been demonstrated to limit ischemia/reperfusion (I/R)‑induced injury and cell apoptosis. In type 2 diabetes mellitus, DZX has been reported to improve β‑cell function and reduce their apoptosis, through suppressing endoplasmic reticulum (ER) stress. However, the effects of DZX on ER stress during I/R‑induced neuronal apoptosis in the hippocampus remains to be elucidated. In the present study, pretreatment of hippocampal neurons with DZX was revealed to inhibit oxygen‑glucose deprivation (OGD)‑stimulated apoptosis in vitro and to alleviate I/R‑induced hippocampal injury and behavioral deficits in rats in vivo...
April 24, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29679541/treatment-with-d-%C3%AE-hydroxybutyrate-protects-heart-from-ischemia-reperfusion-injury-in-mice
#12
Yongsheng Yu, Yunhua Yu, Yuefan Zhang, Zhigang Zhang, Weishuai An, Xianxian Zhao
The present study was designed to examine the protection of D-β-hydroxybutyrate (BHB) against ischemia/reperfusion (I/R) injury in heart and investigate its underlying mechanism. Male adult mice were exposed to 30min of ischemia and 24h of reperfusion. Osmotic pumps were implanted subcutaneously 5min before reperfusion for continuous delivery of the exogenous BHB (1.6mmol/kg/24h). Treatment with BHB reduced infarct size and levels of cardiac troponin I, creatine kinase and lactate dehydrogenase in serum, attenuated apoptosis in myocardium, and preserved cardiac function of I/R mice...
April 18, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29665049/protective-effects-of-progranulin-against-focal-cerebral-ischemia-reperfusion-injury-in-rats-by-suppressing-endoplasmic-reticulum-stress-and-nf-%C3%AE%C2%BAb-activation-in-reactive-astrocytes
#13
Qing Shu, Hua Fan, Shi-Jun Li, Dan Zhou, Wei Ma, Xiao-Yan Zhao, Jun-Qiang Yan, Gang Wu
The aim of this study is to explore the effect progranulin (PGRN) has on endoplasmic reticulum (ER) stress and the NF-κB activation in reactive astrocytes found in rat models with focal cerebral ischemia-reperfusion (I/R) injury. Sprague-Dawley (SD) rats were grouped into the sham, I/R, PGRN-high dose, PGRN-low dose, and negative control (NC) groups. TTC staining was applied in order to detect the cerebral infarction volume, a TUNEL assay to detect the apoptosis rate of neurons, an ELISA to measure MDA, SOD, iNOS, LDH, TNF-α, IL-1β, IL-6, and IL-10 levels, and both RT-qPCR and western blotting methods in order to detect PGRN, GFAP, GRP78, CHOP, and NF-κB p65 expressions...
April 17, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29663377/ubiad1-protects-against-oxygen-glucose-deprivation-reperfusion-induced-multiple-subcellular-organelles-injury-through-pi3k-akt-pathway-in-n2a-cells
#14
Yan Huang, Zhiping Hu
Cerebral ischemia/reperfusion-induced injury plays a significant role in the development of multi-subcellular organelles injury after ischemic stroke. UBIAD1 was discovered originally as a potential tumor suppressor protein. Recently, analysis of UBIAD1 has indicated it is a prenyltransferase enzyme for both non-mitochondrial CoQ10 and vitamin K2 production. Further, UBIAD1 has been localized to multiple subcellular organelles. Particularly, UBIAD1 plays an important role in the regulation of oxidative stress, apoptosis and cell proliferation, cholesterol and lipid metabolism, which was closely associated with the cerebral ischemic/reperfusion mechanism...
April 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29663107/the-serca2-a-gatekeeper-of-neuronal-calcium-homeostasis-in-the-brain
#15
REVIEW
Aikaterini Britzolaki, Joseph Saurine, Emily Flaherty, Connor Thelen, Pothitos M Pitychoutis
Calcium (Ca2+ ) ions are prominent cell signaling regulators that carry information for a variety of cellular processes and are critical for neuronal survival and function. Furthermore, Ca2+ acts as a prominent second messenger that modulates divergent intracellular cascades in the nerve cells. Therefore, nerve cells have developed intricate Ca2+ signaling pathways to couple the Ca2+ signal to their biochemical machinery. Notably, intracellular Ca2+ homeostasis greatly relies on the rapid redistribution of Ca2+ ions into the diverse subcellular organelles which serve as Ca2+ stores, including the endoplasmic reticulum (ER)...
April 16, 2018: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29623030/on-the-role-of-store-operated-calcium-entry-in-acute-and-chronic-neurodegenerative-diseases
#16
REVIEW
Agnese Secondo, Giacinto Bagetta, Diana Amantea
In both excitable and non-excitable cells, calcium (Ca2+ ) signals are maintained by a highly integrated process involving store-operated Ca2+ entry (SOCE), namely the opening of plasma membrane (PM) Ca2+ channels following the release of Ca2+ from intracellular stores. Upon depletion of Ca2+ store, the stromal interaction molecule (STIM) senses Ca2+ level reduction and migrates from endoplasmic reticulum (ER)-like sites to the PM where it activates the channel proteins Orai and/or the transient receptor potential channels (TRPC) prompting Ca2+ refilling...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29620280/melatonin-protects-brain-against-ischemia-reperfusion-injury-by-attenuating-endoplasmic-reticulum-stress
#17
Yu Wen Lin, Tsung Ying Chen, Chia Yang Hung, Shih Huang Tai, Sheng Yang Huang, Che Chao Chang, Hsin Yi Hung, E Jian Lee
Endoplasmic reticulum (ER) stress plays a vital role in mediating ischemic reperfusion damage in brain. In this study, we evaluated whether melatonin inhibits ER stress in cultured neurons exposed to oxygen and glucose deprivation (OGD) and in rats subjected to transient focal cerebral ischemia. Sprague-Dawley rats were treated with melatonin (5 mg/kg) or control at reperfusion onset after transient occlusion of the right middle cerebral artery (MCA) for 90 min. Brain infarction and hemorrhage within infarcts were measured...
July 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29611835/essential-role-for-smooth-muscle-cell-stromal-interaction-molecule-1-in-myocardial-infarction
#18
Vishal Mali, Samuel Haddox, Souad Belmadani, Khalid Matrougui
OBJECTIVES: Stromal interacting molecule-1 (STIM1) plays a role in coordinating calcium signaling in different cell types. The increase or deletion of STIM1 expression in cardiomyocyte causes cardiac complication. Moreover, the deletion of STIM1 in endothelial cell causes vascular endothelial dysfunction. However, the disruption of STIM1 in smooth muscle cells (SMC) has no effect on endothelial function but protects vascular function when mice are infused with angiotensin-II. Nevertheless, the role of SMC-STIM1 in acute and chronic myocardial infarction (MI) induced by acute ischemia-reperfusion injury and permanent coronary artery occlusion is unknown...
February 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29576508/the-desumoylating-enzyme-sentrin-specific-protease-3-contributes-to-myocardial-ischemia-reperfusion-injury
#19
Lingchen Gao, Yichao Zhao, Jie He, Yang Yan, Longwei Xu, Nan Lin, Qingqi Ji, Renyang Tong, Yanan Fu, Yu Gao, Yuanyuan Su, Ancai Yuan, Ben He, Jun Pu
Sentrin-specific protease 3 (SENP3), a member of the desumoylating enzyme family, is known as a redox sensor and could regulate multiple cellular signaling pathways. However, its implication in myocardial ischemia reperfusion (MIR) injury is unclear. Here, we observed that SENP3 was expressed and upregulated in the mouse heart depending on reactive oxygen species (ROS) production in response to MIR injury. By utilizing siRNA-mediated cardiac specific gene silencing, SENP3 knockdown was demonstrated to significantly reduce MIR-induced infarct size and improve cardiac function...
December 29, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29568903/ppar%C3%AE-activation-alleviates-damage-to-the-cytoskeleton-during-acute-myocardial-ischemia-reperfusion-in-rats
#20
Jie Yuan, Hongdan Mo, Jing Luo, Suhong Zhao, Shuang Liang, Yu Jiang, Maomao Zhang
The cytoskeleton serves an important role in maintaining cellular morphology and function, and it is a substrate of calpain during myocardial ischemia/reperfusion (I/R) injury (MIRI). Calpain may be activated by endoplasmic reticulum (ER) stress during MIRI. The activation of peroxisome proliferator‑activated receptor α (PPARα) may inhibit ischemia/reperfusion damage by regulating stress reactions. The present study aimed to determine whether the activation of PPARα protects against MIRI‑induced cytoskeletal degradation, and investigated the underlying mechanism involved...
March 16, 2018: Molecular Medicine Reports
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