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cochlear hair cell

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https://www.readbyqxmd.com/read/27918591/transcriptomic-analysis-of-mouse-cochlear-supporting-cell-maturation-reveals-large-scale-changes-in-notch-responsiveness-prior-to-the-onset-of-hearing
#1
Juan C Maass, Rende Gu, Tiantian Cai, Ying-Wooi Wan, Silvia C Cantellano, Joanna S T Asprer, Hongyuan Zhang, Hsin-I Jen, Renée K Edlund, Zhandong Liu, Andrew K Groves
Neonatal mouse cochlear supporting cells have a limited ability to divide and trans-differentiate into hair cells, but this ability declines rapidly in the two weeks after birth. This decline is concomitant with the morphological and functional maturation of the organ of Corti prior to the onset of hearing. However, despite this association between maturation and loss of regenerative potential, little is known of the molecular changes that underlie these events. To identify these changes, we used RNA-seq to generate transcriptional profiles of purified cochlear supporting cells from 1- and 6-day-old mice...
2016: PloS One
https://www.readbyqxmd.com/read/27917898/incomplete-and-delayed-sox2-deletion-defines-residual-ear-neurosensory-development-and-maintenance
#2
Martina Dvorakova, Israt Jahan, Iva Macova, Tetyana Chumak, Romana Bohuslavova, Josef Syka, Bernd Fritzsch, Gabriela Pavlinkova
The role of Sox2 in neurosensory development is not yet fully understood. Using mice with conditional Islet1-cre mediated deletion of Sox2, we explored the function of Sox2 in neurosensory development in a model with limited cell type diversification, the inner ear. In Sox2 conditional mutants, neurons initially appear to form normally, whereas late- differentiating neurons of the cochlear apex never form. Variable numbers of hair cells differentiate in the utricle, saccule, and cochlear base but sensory epithelium formation is completely absent in the apex and all three cristae of the semicircular canal ampullae...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27916698/cellular-mechanisms-of-noise-induced-hearing-loss
#3
Arwa Kurabi, Elizabeth M Keithley, Gary D Housley, Allen F Ryan, Ann C-Y Wong
Exposure to intense sound or noise can result in purely temporary threshold shift (TTS), or leave a residual permanent threshold shift (PTS) along with alterations in growth functions of auditory nerve output. Recent research has revealed a number of mechanisms that contribute to noise-induced hearing loss (NIHL). The principle cause of NIHL is damage to cochlear hair cells and associated synaptopathy. Contributions to TTS include reversible damage to hair cell (HC) stereocilia or synapses, while moderate TTS reflects protective purinergic hearing adaptation...
December 1, 2016: Hearing Research
https://www.readbyqxmd.com/read/27896618/loss-of-liver-kinase-b1-causes-planar-polarity-defects-in-cochlear-hair-cells-in-mice
#4
Yuqin Men, Aizhen Zhang, Liwen Zhang, Yecheng Jin, Zhishuo Wang, Jing Zhao, Xiaolin Yu, Jian Zhang, Jiangang Gao
The tumor suppressor gene liver kinase B1 (LKB1), also called STK11, encodes a serine/threonine kinase. LKB1 plays crucial roles in cell differentiation, proliferation, and polarity. In this study, LKB1 conditional knockout mice (LKB1(Pax2) CKO mice) were generated using Pax2-Cre mice to investigate the function of LKB1 in inner ear hair cells during early embryonic period. LKB1(Pax2) CKO mice died perinatally. Immunofluorescence and scanning electron microscopy revealed that stereociliary bundles in LKB1(Pax2) CKO mice were clustered and misoriented, respectively...
November 28, 2016: Frontiers of Medicine
https://www.readbyqxmd.com/read/27895287/sudden-sensorineural-hearing-loss-is-there-a-connection-with-inner-ear-electrolytic-disorders-a-literature-review
#5
EDITORIAL
Andrea Ciorba, Virginia Corazzi, Chiara Bianchini, Claudia Aimoni, Henryk Skarzynski, Piotr Henryk Skarzynski, Stavros Hatzopoulos
Electrolytic disorders of the inner ear represent a model that could be implicated in partially explaining the pathogenesis of sudden sensorineural hearing loss (SSNHL). Different types of electrolytes and different inner-ear loci are involved in cochlear homeostasis physiologically, to ensure the maintenance of an ion-balanced cochlear environment allowing a normal hair cell function. It has been hypothesized that a sudden loss of endocochlear potential, due to a rapid disruption of the inner ear fluid osmolality, could be responsible for a deterioration of the hearing function caused by damaged hair cells...
December 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27877041/nanomedicine-strategy-for-optimizing-delivery-to-outer-hair-cells-by-surface-modified-poly-lactic-glycolic-acid-nanoparticles-with-hydrophilic-molecules
#6
Xingxing Wen, Shan Ding, Hui Cai, Junyi Wang, Lu Wen, Fan Yang, Gang Chen
Targeted drug delivery to outer hair cells (OHCs) in the cochlea by nanomedicine strategies forms an effective therapeutic approach for treating hearing loss. Surface chemistry plays a deciding role in nanoparticle (NP) biodistribution, but its influence on such distribution in the cochlea remains largely unknown. Herein, we report the first systematic comparison of poly(lactic/glycolic acid) nanoparticles (PLGA NPs) with or without surface modification of hydrophilic molecules for optimizing the delivery to OHCs both in vitro and in vivo...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27873085/quantitative-analysis-of-supporting-cell-subtype-labeling-among-creer-lines-in-the-neonatal-mouse-cochlea
#7
Melissa M McGovern, Joseph Brancheck, Auston C Grant, Kaley A Graves, Brandon C Cox
Four CreER lines that are commonly used in the auditory field to label cochlear supporting cells (SCs) are expressed in multiple SC subtypes, with some lines also showing reporter expression in hair cells (HCs). We hypothesized that altering the tamoxifen dose would modify CreER expression and target subsets of SCs. We also used two different reporter lines, ROSA26 (tdTomato) and CAG-eGFP, to achieve the same goal. Our results confirm previous reports that Sox2 (CreERT2) and Fgfr3-iCreER (T2) are not only expressed in neonatal SCs but also in HCs...
November 21, 2016: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/27867060/the-role-of-efr3a-in-age-related-hearing-loss
#8
Haixia Hu, Yan Ma, Bin Ye, Quan Wang, Tao Yang, Jingrong Lv, Jun Shi, Hao Wu, Mingliang Xiang
Efr3a has been found to be involved in the functional maintenance and structural degeneration of sensory and motor nervous tissues. Our previous data have suggested that Efr3a may be associated with the initiation of the degeneration of spiral ganglion neurons (SGNs). In this study, we used Efr3a knockdown (Efr3a KD) and Efr3a overexpression (Efr3a OE) mice to determine the role of Efr3a in age-related hearing loss. Measurements of hearing thresholds showed that Efr3a had little or no influence on the hearing threshold at all frequencies in adult mice, whereas in an early stage of senescence, Efr3a reduction resulted in better hearing function, especially at 10 and 12months of age...
November 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27864337/connexin-mediated-signalling-in-non-sensory-cells-is-crucial-for-the-development-of-sensory-inner-hair-cells-in-the-mouse-cochlea
#9
Stuart L Johnson, Federico Ceriani, Oliver Houston, Roman Polishchuk, Elena Polishchuk, Giulia Crispino, Veronica Zorzi, Fabio Mammano, Walter Marcotti
: Mutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin 30 (Cx30) have been linked to syndromic and non-syndromic hearing loss in mice and humans. The release of ATP from connexin hemichannels in cochlear non-sensory cells has been proposed to be the main trigger for action potential (AP) activity in immature sensory inner hair cells (IHCs), which is crucial for the refinement of the developing auditory circuitry. Using connexin knockout mice, we show that IHCs fire spontaneous APs even in the absence of ATP-dependent intercellular Ca(2+) signalling in the non-sensory cells...
November 18, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27861854/lectins-selectively-label-cartilage-condensations-and-the-otic-neuroepithelium-within-the-embryonic-chicken-head
#10
Poulomi Ray, Ami J Hughes, Misha Sharif, Susan C Chapman
Cartilage morphogenesis during endochondral ossification follows a progression of conserved developmental events. Cells are specified towards a prechondrogenic fate and subsequently undergo condensation followed by overt differentiation. Currently available molecular markers of prechondrogenic and condensing mesenchyme rely on common regulators of the chondrogenic program that are not specific to the tissue type or location. Therefore tissue-specific condensations cannot be distinguished based on known molecular markers...
November 16, 2016: Journal of Anatomy
https://www.readbyqxmd.com/read/27858145/role-of-antioxidants-in-prevention-of-age-related-hearing-loss-a-review-of-literature
#11
REVIEW
Elham Tavanai, Ghassem Mohammadkhani
Age-related hearing loss (ARHL), also known as presbycusis, is one of the most prevalent chronic degenerative conditions. It is characterized by a decline in auditory function. ARHL is caused by the interaction of multiple factors, including cochlear aging, environment, genetic predisposition, and health comorbidities. The primary pathology of ARHL includes the hair cells loss, stria vascularis atrophy, and loss of spiral ganglion neurons as well as the changes in central auditory pathways. The research to date suggests that oxidative stress and mitochondrial DNA deletion (mtDNA) play a major role in pathophysiology of ARHL...
November 17, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27846039/activation-of-igf1-signaling-in-the-cochlea-induces-the-transcription-of-its-mediators-during-the-protection-of-cochlear-hair-cells-against-aminoglycoside
#12
Yushi Hayashi, Norio Yamamoto, Takayuki Nakagawa, Koichi Omori, Juichi Ito
HYPOTHESIS: Transcription of the Erk and Akt genes and phosphorylation of their products are promoted by insulin-like growth factor 1 (IGF1) during hair cell protection. BACKGROUND: IGF1 protects mammalian hair cells in animal models from various types of damage, including aminoglycoside. Moreover, clinical trials have revealed that IGF1 was effective for idiopathic sudden sensorineural hearing loss. In this process, activation of the downstream of IGF1 signaling, including the phosphorylation of extracellular signal-regulated kinase (ERK) and AKT proteins, is involved...
November 14, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27837052/individual-differences-in-auditory-brainstem-response-wave-characteristics-relations-to-different-aspects-of-peripheral-hearing-loss
#13
Sarah Verhulst, Anoop Jagadeesh, Manfred Mauermann, Frauke Ernst
Little is known about how outer hair cell loss interacts with noise-induced and age-related auditory nerve degradation (i.e., cochlear synaptopathy) to affect auditory brainstem response (ABR) wave characteristics. Given that listeners with impaired audiograms likely suffer from mixtures of these hearing deficits and that ABR amplitudes have successfully been used to isolate synaptopathy in listeners with normal audiograms, an improved understanding of how different hearing pathologies affect the ABR source generators will improve their sensitivity in hearing diagnostics...
November 11, 2016: Trends in Hearing
https://www.readbyqxmd.com/read/27821621/dopamine-d1a-directly-interacts-with-otoferlin-synaptic-pathway-proteins-ca2-and-phosphorylation-underlie-an-nsf-to-ap2mu1-molecular-switch
#14
Dakshnamurthy Selvakumar, Marian J Drescher, Nathan A Deckard, Neeliyath A Ramakrishnan, Barbara J Morley, Dennis G Drescher
Dopamine receptors regulate exocytosis via protein-protein interactions (PPIs) as well as via adenylyl cyclase transduction pathways. Evidence has been obtained for PPIs in inner ear hair cells coupling D1A to SNARE-related proteins snapin, otoferlin, NSF, and AP2mu1, dependent on [Ca(2+)] and phosphorylation. Specifically, the carboxy terminus of dopamine D1A was found to directly bind t-SNARE-associated protein snapin in teleost and mammalian hair cell models by yeast two-hybrid and pull-down assays, and snapin directly interacts with  hair cell calcium-sensor otoferlin...
November 7, 2016: Biochemical Journal
https://www.readbyqxmd.com/read/27807171/effects-of-long-term-exercise-on-age-related-hearing-loss-in-mice
#15
Chul Han, Dalian Ding, Maria-Cecilia Lopez, Senthilvelan Manohar, Yanping Zhang, Mi-Jung Kim, Hyo-Jin Park, Karessa White, Yong Hwan Kim, Paul Linser, Masaru Tanokura, Christiaan Leeuwenburgh, Henry V Baker, Richard J Salvi, Shinichi Someya
: Regular physical exercise reduces the risk for obesity, cardiovascular diseases, and disability and is associated with longer lifespan expectancy (Taylor et al., 2004; Pahor et al., 2014; Anton et al., 2015; Arem et al., 2015). In contrast, decreased physical function is associated with hearing loss among older adults (Li et al., 2013; Chen et al., 2015). Here, we investigated the effects of long-term voluntary wheel running (WR) on age-related hearing loss (AHL) in CBA/CaJ mice, a well established model of AHL (Zheng et al...
November 2, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27805613/spiral-ganglion-neuron-explant-culture-and-electrophysiology-on-multi-electrode-arrays
#16
Stefan Hahnewald, Marta Roccio, Anne Tscherter, Jürg Streit, Ranjeeta Ambett, Pascal Senn
Spiral ganglion neurons (SGNs) participate in the physiological process of hearing by relaying signals from sensory hair cells to the cochlear nucleus in the brain stem. Loss of hair cells is a major cause of sensory hearing loss. Prosthetic devices such as cochlear implants function by bypassing lost hair cells and directly stimulating SGNs electrically, allowing for restoration of hearing in deaf patients. The performance of these devices depends on the functionality of SGNs, the implantation procedure and on the distance between the electrodes and the auditory neurons...
October 19, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27798720/electrically-evoked-medial-olivocochlear-efferent-effects-on-stimulus-frequency-otoacoustic-emissions-in-guinea-pigs
#17
Maria A Berezina-Greene, John J Guinan
Stimulus frequency otoacoustic emissions (SFOAEs) are produced by cochlear irregularities reflecting energy from the peak region of the traveling wave (TW). Activation of medial olivocochlear (MOC) efferents reduces cochlear amplification and otoacoustic emissions (OAEs). In other OAEs, MOC activation can produce enhancements. The extent of MOC enhancements of SFOAEs has not been previously studied. In anesthetized guinea pigs, we electrically stimulated MOC fibers and recorded their effects on SFOAEs. MOC stimulation mostly inhibited SFOAEs but sometimes enhanced them...
October 31, 2016: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/27794305/the-role-of-compression-in-the-simultaneous-masker-phase-effect
#18
Hisaaki Tabuchi, Bernhard Laback, Thibaud Necciari, Piotr Majdak
Peripheral compression is believed to play a major role in the masker phase effect (MPE). While compression is almost instantaneous, activation of the efferent system reduces compression in a temporally evolving manner. To study the role of efferent-controlled compression in the MPE, in experiment 1, simultaneous masking of a 30-ms 4-kHz tone by 40-ms Schroeder-phase harmonic complexes was measured with on- and off-frequency precursors as a function of masker phase curvature for two masker levels (60 and 90 dB sound pressure level)...
October 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27794298/finite-element-modelling-of-cochlear-electrical-coupling
#19
Paul D Teal, Guangjian Ni
The operation of each hair cell within the cochlea generates a change in electrical potential at the frequency of the vibrating basilar membrane beneath the hair cell. This electrical potential influences the operation of the cochlea at nearby locations and can also be detected as the cochlear microphonic signal. The effect of such potentials has been proposed as a mechanism for the non-local operation of the cochlear amplifier, and the interaction of such potentials has been thought to be the cause of the broadness of cochlea microphonic tuning curves...
October 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27794029/reversible-p53-inhibition-prevents-cisplatin%C3%A2-ototoxicity-without-blocking-chemotherapeutic-efficacy
#20
Nesrine Benkafadar, Julien Menardo, Jérôme Bourien, Régis Nouvian, Florence François, Didier Decaudin, Domenico Maiorano, Jean-Luc Puel, Jing Wang
Cisplatin is a widely used chemotherapy drug, despite its significant ototoxic side effects. To date, the mechanism of cisplatin-induced ototoxicity remains unclear, and hearing preservation during cisplatin-based chemotherapy in patients is lacking. We found activation of the ATM-Chk2-p53 pathway to be a major determinant of cisplatin ototoxicity. However, prevention of cisplatin-induced ototoxicity is hampered by opposite effects of ATM activation upon sensory hair cells: promoting both outer hair cell death and inner hair cell survival...
October 28, 2016: EMBO Molecular Medicine
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