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https://www.readbyqxmd.com/read/29774477/cefepime-vs-cefoperazone-sulbactam-in-combination-with-amikacin-as-empirical-antibiotic-therapy-in-febrile-neutropenia
#1
M Ponraj, Biswajit Dubashi, B H Harish, S Kayal, S L Cyriac, Jogamaya Pattnaik, K Ranjith, Unni S Pillai, Naresh Jadhav, Kiran K Matta, Jagdeep Singh, Esha Jaffa, Bhanu Prakash
PURPOSE: Beta lactams are standard empirical therapy for febrile neutropenia (FN). The aim of this study was to evaluate the efficacy and safety of cefepime monotherapy compared with cefoperazone/sulbactam plus amikacin (CS + A) for empirical treatment of high risk FN. METHODS: One hundred seventy-five patients with 336 FN episodes were randomized to receive either cefepime (2 g q8h for adults and 50 mg/kg q8h for children) or CS (2 g q8h for adults and 50 mg/kg q8h for children) plus amikacin (15 mg/kg once a day)...
May 17, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29768382/transbronchial-drainage-using-endobronchial-ultrasonography-with-guide-sheath-for-lung-abscess-a-case-report
#2
Daizo Yaguchi, Motoshi Ichikawa, Noriko Inoue, Daisuke Kobayashi, Masato Shizu, Naoyuki Imai
RATIONALE: Lung abscess was previously treated surgically, but is now mainly treated with antibiotics and ideally with direct drainage, although postural drainage canalso be used. PATIENT CONCERNS: A chest abnormal shadow was detected in an 82-year-old man and he was referred to our department in November 2017. On chest computed tomography (CT), a low-density mass shadow was present in the left S8 segment. Lung abscess and lung cancer were considered as differential diagnoses, and treatment with sulbactam sodium/ampicillin sodium (SBT/ABPC) was first initiated for lung abscess...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29753682/class-a-%C3%AE-lactamases-and-inhibitors-in-silico-analysis-of-the-binding-mode-and-the-relationship-with-resistance
#3
Rebeca Pereira, Vitor Won-Held Rabelo, Alexander Sibajev, Paula Alvarez Abreu, Helena Carla Castro
β-lactams are one of the most common antimicrobials used to treat bacterial infections. However, bacterial resistance has compromised their efficacy, mainly due to β-lactamase enzyme production. To overcome this resistance, β-lactamase inhibitors can be used in association with these antimicrobials. Herein, we analyzed the structural characteristics of β-lactamases and their interactions with classical inhibitors, such as clavulanic acid (CA), sulbactam (SB) and tazobactam (TZ) to gain insights into resistance...
May 10, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29735843/-in-silico-and-in-vitro-activity-of-ceftolozane-tazobactam-against-pseudomonas-aeruginosa-collected-across-indian-hospitals
#4
Agila Kumari Pragsam, D Thirumal Kumar, C George Priya Doss, Ramya Iyadurai, Sowmya Satyendra, Camilla Rodrigues, Sangeeta Joshi, Indranil Roy, Bhaskar Narayan Chaudhuri, D S Chitnis, Dhole Tapan, Balaji Veeraraghavan
Ceftolozane/tazobactam is a novel antimicrobial agent with activity against Pseudomonas aeruginosa and other common Gram-negative pathogens. In this study, we determined the antimicrobial susceptibility for a total of 149 clinical isolates of P. aeruginosa for the most commonly used antimicrobials including the new agent ceftolozane/tazobactam (C/T). Broth microdilution was performed to determine the minimum inhibitory concentration against various antimicrobials including C/T. Among the β-lactam/β-lactamase inhibitor, overall susceptibility was 67%, 55% and 51% for C/T, Piperacillin/Tazobactam (P/T) and Cefoperazone/Sulbactam, respectively...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29734941/infective-endocarditis-due-to-burkholderia-cepacia-in-a-neonate-a-case-report
#5
Emir Yonas, Vito Damay, Raymond Pranata, Nuvi Nusarintowati
BACKGROUND: Burkholderia is a pathogen that is rarely seen in clinical cases. However, this organism is being found more commonly in hospitals. CASE PRESENTATION: A female Indonesian newborn was referred to our neonatal intensive care unit because of respiratory distress. The newborn had been delivered the previous night via cesarean section. A physical examination revealed intercostal retractions and weak cry. The newborn's gestational history was preterm, small for gestational age, and preterm premature ruptured membrane for 14 hours...
May 8, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29732380/antimicrobial-agent-shortages-the-new-norm-for-infectious-diseases-physicians
#6
Adi V Gundlapalli, Susan E Beekmann, Donald R Graham, Philip M Polgreen
Background: In 2012, the US Food and Drug Administration (FDA) required drug manufacturers to give advance notice of impending drug shortages. A survey of infectious diseases (ID) physicians was undertaken to determine the impact of this requirement and to follow-up on prior perceptions of ID physicians on shortages of antimicrobial agents. Methods: We used a web-based survey of ID physician members of the Emerging Infections Network in 2016. Results: Of the 701 of 1597 members (44%) who responded, 70% reported the need to modify their antimicrobial choice because of a shortage in the prior 2 years...
April 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29707286/-in-vitro-assessment-of-cefoperazone-sulbactam-based-combination-therapy-for-multidrug-resistant-acinetobacter-baumannii-isolates-in-china
#7
Tao Li, Meiyan Sheng, Tengzhen Gu, Yan Zhang, Ailiyaer Yirepanjiang, Yu Li
Background: Multidrug-resistant Acinetobacter baumannii (MDRAB) has emerged as an important pathogen of nosocomial infections. Even though cefoperazone-sulbactam is frequently used to treat MDRAB infections, this single-drug therapeutic approach often results in antibiotic resistance. Thus, combination therapy is preferred over single-drug therapy, particularly in the case of carbapenemase-producing gram negative bacteria. The aim of this study was to investigate the efficacy of cefoperazone-sulbactam combined with either tigecycline or rifampicin against clinical isolates of MDRAB...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29703650/lung-abscess-following-bronchoscopy-due-to-multidrug-resistant-capnocytophaga-sputigena-adjacent-to-lung-cancer-with-high-pd-l1-expression
#8
Yohei Migiyama, Moriyasu Anai, Kosuke Kashiwabara, Yusuke Tomita, Sho Saeki, Kazuyoshi Nakamura, Shinichiro Okamoto, Hidenori Ichiyasu, Kazuhiko Fujii, Hirotsugu Kohrogi
Lung abscess following flexible bronchoscopy is a rare and sometimes fatal iatrogenic complication. Here, we report the first case of a lung abscess caused by multidrug-resistant Capnocytophaga sputigena following bronchoscopy. A 67-year-old man underwent bronchoscopy to evaluate a lung mass. Seven days after transbronchial lung biopsy, he presented with an abscess formation in a lung mass. Empirical antibiotic therapy, including with garenoxacin, ampicillin/sulbactam, clindamycin and cefepime, was ineffective...
April 24, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29693161/study-on-the-association-between-drug%C3%A2-resistance-and-gene-mutations-of-the-active-efflux-pump-acrab%C3%A2-tolc-gene-and-its-regulatory-genes
#9
Quan-Ping Ma, Liang Su, Jing-Wen Liu, Ming-Xiao Yao, Guang-Ying Yuan
The aim of the present study was to investigate the correlation between the multi‑drug resistance of Shigella flexneri and the drug‑resistant gene cassette carried by integrons; in the meanwhile, to detect the associations between drug‑resistance and gene mutations of the active efflux pump acrAB‑tolC gene and its regulatory genes, including marOR, acrR and soxS. A total of 158 isolates were isolated from the stool samples of 1,026 children with diarrhoea aged 14 years old between May 2012 and October 2015 in Henan...
April 23, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29692359/seminal-fluid-metabolome-and-epididymal-changes-after-antibiotic-treatment-in-mice
#10
Cheryl Susan Rosenfeld, Angela B Javurek, Sarah A Johnson, Zhentian Lei, Lloyd W Summer, Rex A Hess
Paternal environment can induce detrimental developmental origins of health and disease (DOHaD) effects in resulting offspring and even future descendants. Such paternal-induced DOHaD effects might originate from alterations in a possible seminal fluid microbiome (SFM) and composite metabolome. Seminal vesicles secrete a slightly basic product enriched with fructose and other carbohydrates, providing an ideal habitat for microorganisms. Past studies confirm the existence of a SFM that is influenced by genetic and nutritional status...
April 24, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29669956/nosocomial-pneumonia-search-for-an-empiric-and-effective-antibiotic-regimen-in-high-burden-tertiary-care-centre
#11
Nitin Gupta, Manish Soneja, Yogiraj Ray, Monalisa Sahu, Kutty Sharada Vinod, Arti Kapil, Ashutosh Biswas, Naveet Wig, Rita Sood
The clinical practice guidelines on nosocomial pneumonia recommends an empirical regimen that would work in 95% of the patients based on the local antibiogram. The aim of the study was development of an antibiogram for guiding empiric therapy in settings with high prevalence of multi-drug resistant organisms. A retrospective review of electronic health records (e-hospital portal) was done to analyze all respiratory isolates from patients admitted in medical wards and intensive care unit between May 2016 and May 2017...
April 17, 2018: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29623072/biodiversity-and-microbial-resistance-of-lactobacilli-isolated-from-the-traditional-greek-cheese-kopanisti
#12
Georgios Rozos, Chrysa Voidarou, Elisavet Stavropoulou, Ioannis Skoufos, Athina Tzora, Athanasios Alexopoulos, Eugenia Bezirtzoglou
Kopanisti is a Greek artisan cheese produced from raw milk in the island of Mykonos, Greece. The milk is left to rest for 12-24 h and then the rennet is added. After its formation the curd is left to drain for 2-3 days and is ready either for consumption (as tyrovolia fresh cheese), or with the addition of extra salt, the curd is left to ripen through further fermentation and surface development of Penicillium fungi, aprocess leading to the production of the traditional Greek cheese Kopanisti. From 120 samples of kopanisti, 574 Lactobacillus strains were isolated, distributed in 17 species (16 of them isolated from tyrovolia as well)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29615167/pseudomonas-aeruginosa-evaluation-of-pathogen-burden-and-drug-resistance-trends-in-a-tertiary-care-hospital
#13
Muhammad Saeed, Farhan Rasheed, Raja Kamran Afzal, Shahida Hussain, Saba Riaz, Adeel Ahmad
OBJECTIVE: To evaluate the pathogen burden and antibiotic-resistance trends of Pseudomonas aeruginosa among hospitalised patients at a tertiary care hospital. STUDY DESIGN: Retrospective, hospital record-based, cross-sectional study. PLACE AND DURATION OF STUDY: Microbiology Laboratory, Allama Iqbal Medical College/Jinnah Hospital, Lahore, from January 2014 to December 2016. METHODOLOGY: A total of 5,960 samples were collected from clinically suspected cases of bacterial infections, admitted to the hospital...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29615129/antimicrobial-susceptibility-pattern-of-staphylococcus-aureus-isolates-from-clinical-specimens-at-kenyatta-national-hospital
#14
Wilfred Gitau, Moses Masika, Moses Musyoki, Beatrice Museve, Titus Mutwiri
OBJECTIVE: To determine antibiotic susceptibility pattern of S. aureus isolates from clinical specimens collected from patients at Kenyatta National Hospital from March 2014-February 2016, and to determine the prevalence and quarterly trends of MRSA throughout the study period. RESULTS: A total of 944 S. aureus isolates were analyzed. High sensitivity of S. aureus was observed for quinupristin/dalfopristin (100%), tigecycline (98.2), imipenem (98%), nitrofurantoin (97...
April 3, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29614601/-antimicrobial-susceptibility-and-drug-resistance-genes-of-yersinia-spp-of-retailed-poultry-in-4-provinces-of-china
#15
Z X Peng, M Y Zou, J Xu, W Y Guan, Y Li, D R Liu, S S Zhang, Q Hao, S F Yan, W Wang, D M Yu, F Q Li
Objective: To monitor the antimicrobial resistance and drug-resistance genes of Yersinia enterocolitis , Y. intermedia and Y. frederiksenii recovered from retailed fresh poultry of 4 provinces of China. Methods: The susceptibility of 25 isolated Yersinia spp. to 14 classes and 25 kinds of antibiotics was determined by broth microdilution method according to CLSI (Clinical and Laboratory Standards Institute). The antibiotic resistance genes were predicted with antibiotic resistance genes database (ARDB) using whole genome sequences of Yersinia spp...
April 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29609277/-analysis-of-distribution-and-drug-resistance-of-pathogens-of-burn-patients-during-9-years
#16
Y Dou, Q Zhang
Objective: To investigate distribution and drug resistance of pathogens of burn patients. Methods: A total of 3 357 strains were cultured and isolated from 25 286 specimens of wounds excretion, deep venous catheters, venous blood, stool, mid-stream urine, sputum, puncture fluid, and throat swab of 11 510 burn patients hospitalized in our burn wards from January 2007 to December 2015. After being identified by API bacteria identification panels and automatically bacteria identification equipment, drug-resistances of Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae to 28 common antibiotics were tested by drug sensitivity test with K-B paper disk diffusion method...
March 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29593912/antimicrobial-susceptibility-among-colistin-sulbactam-and-fosfomycin-and-a-synergism-study-of-colistin-in-combination-with-sulbactam-or-fosfomycin-against-clinical-isolates-of-carbapenem-resistant-acinetobacter-baumannii
#17
Sombat Leelasupasri, Wichai Santimaleeworagun, Tossawan Jitwasinkul
This in vitro study aimed to determine the activity of colistin plus sulbactam and colistin plus fosfomycin against carbapenem-resistant A. baumannii (CRAB). Fifteen clinical isolates were obtained from patients admitted to Phyathai II International Hospital, Bangkok, Thailand, from August 2014 to April 2015. The antimicrobial susceptibilities of colistin, sulbactam, and fosfomycin were evaluated using the E-test or broth microdilution and the synergistic activity of the antibacterial combinations (colistin plus sulbactam or fosfomycin) was determined using the chequerboard method...
2018: Journal of Pathogens
https://www.readbyqxmd.com/read/29579634/separation-and-characterization-of-allergenic-polymerized-impurities-from-cephalosporin-for-injection-by-trap-free-two-dimensional-high-performance-size-exclusion-chromatography-%C3%A3-reversed-phase-liquid-chromatography-coupled-with-ion-trap-time-of-flight-mass
#18
Yu Xu, Dandan Wang, Bingqi Zhu, Lan Tang, Jian Wang
As requested by regulatory authorities, polymerized impurities are an important issue of quality control. In this study, we presented the utilization of a trap-free two-dimensional chromatography, which was consisted by a high performance size exclusion chromatography (HPSEC) and a reversed-phase liquid chromatography (RP-LC) coupled to ion trap time-of-flight mass spectrometry with positive mode of electrospray ionization, to separate and characterize ten allergenic impurities in ceftazidime for injection, cefazolin sodium for injection, cefoperazone sodium and sulbactam sodium for injection and cefamandole nafate for injection...
March 20, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29564231/preliminary-study-on-the-antimicrobial-susceptibility-pattern-related-to-the-genotype-of-vibrio-vulnificus-strains-isolated-in-the-north-western-adriatic-sea-coastal-area
#19
Patrizia Serratore, Emanuele Zavatta, Eleonora Fiocchi, Emanuele Serafini, Andrea Serraino, Federica Giacometti, Giorgia Bignami
V. vulnificus is a Gram-negative bacterium, commonly found in estuarine and coastal habitats, that can infect humans through seafood consumption or wound exposure. This study represents the first attempt to correlate the genotype of Vibrio vulnificus strains isolated in the north-western Adriatic Sea coastal area, with their antimicrobial susceptibility patterns. On the whole, 40 V. vulnificus strains, isolated from shellfish (n=20), different coastal water bodies (n=19), and the blood of a Carretta carretta turtle (n=1), were utilized...
October 20, 2017: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/29560642/minimally-invasive-treatment-of-hepatic-hydatid-disease-with-perforator-grinder-aspirator-apparatus-and-follow-up-of-42-patients
#20
I C Sormaz, L Avtan
INTRODUCTION: The gold standard treatment for hydatid cyst (HC) is surgery. In surgical practice, open procedures still remain as the first option but in this minimally-invasive era, the frequency of laparoscopic procedures is increasing. The aim of this study is to evaluate the results of 42 patients with HC who underwent surgery with Perforator-Grinder-Aspirator-Apparatus (PGAA) and demonstrate the success and reliability of this technique. METHODS: The datas of 42 patients, who underwent laparoscopic surgery with PGAA between Jan 2010 and Feb 2016 were evaluated retrospectively...
October 2017: Acta Gastro-enterologica Belgica
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