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https://www.readbyqxmd.com/read/28629795/epidemiological-features-and-antibiotic-resistance-patterns-of-haemophilus-influenzae-originating-from-respiratory-tract-and-vaginal-specimens-in-pediatric-patients
#1
Jian-Ping Li, Chun-Zhen Hua, Li-Ying Sun, Hong-Jiao Wang, Zhi-Min Chen, Shi-Qiang Shang
BACKGROUND: Haemophilus influenzae (H. influenzae) is a common pathogen of respiratory tract infections in children, however, as a possible cause of vulvovaginitis in prepubertal girls, its epidemiological features,antibiotic-resistance patterns, and treatment are seldom noted. METHODS: Specimens obtained from patients were inoculated on Haemophilus selective medium; and drug-sensitivities tests were determined with disc diffusion method. Cefinase disc was used to detect β-lactamase...
June 16, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28629721/a-16-year-retrospective-surveillance-report-on-the-pathogenic-features-and-antimicrobial-susceptibility-of-pseudomonas-aeruginosa-isolates-from-fahju-in-guangzhou-representative-of-southern-china
#2
Jinhong Xie, Ling Yang, Brian M Peters, Lequn Chen, Dingqiang Chen, Bing Li, Lin Li, Guangchao Yu, Zhenbo Xu, Mark E Shirtliff
Pseudomonas aeruginosa is a major pathogen responsible for nosocomial infections. A 16-year retrospective report from 2000 to 2015 was conducted to assess the antimicrobial resistance of P. aeruginosa in Southern China. A total of 1387 P. aeruginosa were collected from inpatients and outpatients. Susceptibility testing results were interpreted according to the Clinical and Laboratory Standards Institute (CLSI, 2015). Piperacillin, piperacillin-tazobactam, ceftazidime, aminoglycosides and carbapenems remained to be active against P...
June 16, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28624317/modulatory-effects-of-ampicillin-sulbactam-on-glial-glutamate-transporters-and-metabotropic-glutamate-receptor-1-as-well-as-reinstatement-to-cocaine-seeking-behavior
#3
Alaa M Hammad, Fawaz Alasmari, Yusuf S Althobaiti, Youssef Sari
The glutamatergic system has an important role in cocaine-seeking behavior. Studies have reported that chronic exposure to cocaine induces downregulation of glutamate transporter-1 (GLT-1) and cystine/glutamate exchanger (xCT) in the central reward brain regions. Ceftriaxone, a β-lactam antibiotic, restored GLT-1 expression and consequently reduced cue-induced reinstatement of cocaine-seeking behavior. In this study, we investigated the reinstatement to cocaine (20mg/kg, i.p.) seeking behavior using a conditioned place preference (CPP) paradigm in male alcohol-preferring (P) rats...
June 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28616693/-tinea-barbae-profunda-due-to-trichophyton-mentagrophytes-after-journey-to-thailand-case-report-and-review
#4
REVIEW
G Wendrock-Shiga, D Mechtel, S Uhrlaß, D Koch, C Krüger, P Nenoff
Tinea barbae represents a very rare dermatophytosis. We report on a tinea barbae profunda following a journey to Southeast Asia. After travel to Thailand, a businessman was affected by a foudroyant proceeding abscessing infection of the upper lip and beard area. The initial therapy with oral acyclovir and oral ciprofloxacin, which later was changed to ampicillin plus sulbactam, intravenously, was unsuccessful. In a biopsy sample, histologically, with Grocott-Gomori's methenamine silver stain, fungal mycelium was apparent in the tissue...
June 14, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28591808/relationship-between-%C3%AE-lactamase-production-and-resistance-phenotype-in-klebsiella-pneumoniae-strains
#5
Jeongjin Kim, Tian Ding, Juhee Ahn
This study was designed to evaluate the resistance phenotypes of β-lactamases-producing Klebsiella pneumoniae strains. The antibiotic susceptibility and β-lactamase activity of K. pneumoniae strains, including antibiotic-sensitive K. pneumoniae (KPWT), ciprofloxacin-induced resistant K. pneumoniae (KPCIP), and clinically isolated K. pneumoniae strains (KPCI237, KPCI263, and KPCI272), were determined in the absence and presence of β-lactamase inhibitors (BLI 489, sulbactam, clavulanate, and tazobactam). All strains were highly resistant to ampicillin in the absence of β-lactamase inhibitors (MIC≥ 512 μg mL-1)...
June 7, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28584435/a-study-of-24-patients-with-colistin-resistant-gram-negative-isolates-in-a-tertiary-care-hospital-in-south-india
#6
Rajalakshmi Arjun, Ram Gopalakrishnan, P Senthur Nambi, D Suresh Kumar, R Madhumitha, V Ramasubramanian
BACKGROUND: As the use of colistin to treat carbapenem-resistant Gram-negative infections increases, colistin resistance is being increasingly reported in Indian hospitals. MATERIALS AND METHODS: Retrospective chart review of clinical data from patients with colistin-resistant isolates (minimum inhibitory concentration >2 mcg/ml). Clinical profile, outcome, and antibiotics that were used for treatment were analyzed. RESULTS: Twenty-four colistin-resistant isolates were reported over 18 months (January 2014-June 2015)...
May 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28556289/influence-of-regular-reporting-on-local-pseudomonas-aeruginosa-and-acinetobacter-spp-sensitivity-to-antibiotics-on-consumption-of-antibiotics-and-resistance-patterns
#7
Z M Djordjevic, M M Folic, S M Jankovic
WHAT IS KNOWN AND OBJECTIVE: Regular surveillance of antimicrobial resistance is an important component of multifaceted interventions directed at the problem with resistance of bacteria causing healthcare-associated infections (HAIs) in intensive care units (ICUs). Our aim was to analyse antimicrobial consumption and resistance among isolates of Pseudomonas aeruginosa and Acinetobacter spp. causing HAIs, before and after the introduction of mandatory reporting of resistance patterns to prescribers...
May 27, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28552416/case-of-pacemaker-pocket-infection-caused-by-finegoldia-magna
#8
Seyed Hamed Hosseini Dehkordi, Georgina Osorio
Finegoldia magna (formerly called Peptostreptococcus magnus) is a Gram-positive anaerobic coccus which is increasingly recognized as an opportunistic pathogen. We present a case of F. magna associated non-valvular cardiovascular device-related infection in an 83 year-old male who received a permanent pacemaker for sick sinus syndrome seven weeks prior to his presentation. Five weeks after the implantation, the pacemaker and leads were explanted because of clinical evidence of pacemaker pocket infection. He was initially treated with sulfamethoxazole-trimethoprim based on the Gram stain results from the removed pacemaker...
May 25, 2017: Anaerobe
https://www.readbyqxmd.com/read/28535440/management-of-ventilator-associated-pneumonia-with-a-new-antibiotic-adjuvant-entity-ceftriaxone-sulbactam-disodium-edetate-a-novel-approach-to-spare-carbapenems
#9
Prachee Sathe, Sagar Maddani, Shilpa Kulkarni, Nita Munshi
BACKGROUND: Ventilator associated pneumonia (VAP) is one of the most serious nosocomial infections in Intensive Care Unit (ICU). The aim of this study was to evaluate a new approach to spare the carbapenems for the management of patients diagnosed with VAP due to Acinetobacter baumannii (A. baumannii). METHOD: This retrospective study was conducted on VAP patients presenting for treatment at tertiary care centre between May 2014 and March 2016. The case sheets of patients who have been treated for VAP with meropenem, antibiotic adjuvant entity (AAE) and colistin were analysed...
May 15, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28491325/propionimicrobium-lymphophilum-and-actinotignum-schaalii-bacteraemia-a-case-report
#10
M Ikeda, T Kobayashi, T Suzuki, Y Wakabayashi, Y Ohama, S Maekawa, S Takahashi, Y Homma, K Tatsuno, T Sato, S Okugawa, K Moriya, H Yotsuyanagi
Propionimicrobium lymphophilum is an anaerobic Gram-positive bacillus that exists in human skin and urinary tract. The pathogenicity is, however, not well known. Only two cases of urinary tract infection have been described recently. In the case presented here, the bacterium was isolated, concomitant with Actinotignum schaalii, from blood culture of a patient with fever and difficulty of urination. The bacteria were identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and 16S rRNA sequencing...
July 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/28484782/necrotizing-fasciitis-treatment-concepts-and-clinical-results
#11
M Leiblein, I Marzi, A L Sander, J H Barker, F Ebert, J Frank
BACKGROUND: Necrotizing fasciitis is a life-threatening soft tissue infection characterized by a rapid spreading infection of the subcutaneous tissue and in particular the fascia. The management of infected tissues requires a rapid diagnosis, immediate aggressive surgical management and an extended debridement. In some cases early amputations of the affected tissues and maximum intensive care treatment, in case of sepsis, are required. Due to a rising number of cases we aimed to evaluate our patients in a retrospective review...
May 8, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28483954/genetic-and-functional-characterization-of-blactx-m-199-a-novel-tazobactam-and-sulbactam-resistance-encoding-gene-located-in-a-conjugative-mcr-1-bearing-inci2-plasmid
#12
Jiachang Cai, Qipeng Cheng, Yingbo Shen, Danxia Gu, Ying Fang, Edward Wai-Chi Chan, Sheng Chen
The study reported the genetic and functional characterization of a novel CTX-M-199 β-lactamase, which was encoded by a blaCTX-M-64 variant gene found in a conjugative mcr-1-bearing IncI2 plasmid and exhibited resistance to β-lactamase inhibitors, tazobactam and sulbactam.
May 8, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28464580/-analysis-of-the-spectrum-and-resistance-of-pathogen-causing-sepsis-in-patients-with-severe-acute-pancreatitis
#13
H X Ma, L He, S W Cai, X L Xin, H D Shi, L Zhou, X J Shi
Objective: To investigate the characteristics of spectrum and drug resistance of pathogens causing sepsis in patients with severe acute pancreatitis(SAP). Methods: The clinical data of 63 SAP patients with sepsis admitted in Department of Hepatobiliary, People's Liberation Army General Hospital from January 2014 to December 2015 were retrospectively studied. There were 47 males and 16 females, aged from 22 to 73 years, with an average age of (52±11)years. Samples were collected mainly from: (1)pancreatic and peripancreatic necrosis and abdominal drainage; (2)bile; (3) blood or deep venous catheter; (4) sputum and tracheal catheter and thoracic drainage; (5) urine...
May 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28463218/-aerobic-etiology-of-acute-appendicitis-in-adults-multicenter-study-of-abdominal-sepsis-in-argentina
#14
Pablo G Scapellato, Pedro Pessacq, Alejandra Corso, Fernando Pasteran, Melina Rapoport, Walter Vasen, Corina Nemirovsky, Aníbal Calmaggi
Antibiotic treatment for acute appendicitis is empirically chosen, based on epidemiological information. Resistance rates are different between regions and there are limited data on the situation in Argentina. As a part of a multicenter, observational study of abdominal infections, we performed the analysis of adult patients diagnosed with appendicitis, enrolled in 16 centers of 5 provinces, between Jan/01/2014 and Jun/30/2015. The aim was to analyze the prevalent aerobic pathogens, their resistance rates and the antimicrobial prescription pattern...
2017: Medicina
https://www.readbyqxmd.com/read/28443385/pseudomonas-aeruginosa-prevalence-antibiotic-resistance-and-antimicrobial-use-in-chinese-burn-wards-from-2007-to-2014
#15
Yi Dou, Jingning Huan, Feng Guo, Zengding Zhou, Yan Shi
Objective To assess the application of antibacterial agents, alongside pathogen prevalence and Pseudomonas aeruginosa drug resistance, with the aim of understanding the impact of inappropriate antibacterial use. Methods This retrospective study assessed bacteria from wounds, catheters, blood, faeces, urine and sputum of hospitalized patients in burn wards between 2007 and 2014. The intensity of use of antibacterial agents and resistance of P. aeruginosa to common anti-Gram-negative antibiotics were measured...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28439680/microbiological-evaluation-of-infected-pelvic-lymphocele-after-robotic-prostatectomy-potential-predictors-for-culture-positivity-and-selection-of-the-best-empirical-antimicrobial-therapy
#16
Alaa Hamada, Catalina Hwang, Jorge Fleisher, Ingolf Tuerk
OBJECTIVES: To examine symptomatology and microbiology of infected lymphocele (LC) post-robotic-assisted radical prostatectomy and pelvic lymph node dissection (PLND) and to assess for potential predictors for LC fluid culture positivity. Secondly, to provide general recommendations about use of select antimicrobial therapy. METHODS: This was a single-center, IRB-approved, retrospective, case series review conducted between October 2008 and October 2014. Data included symptomatology, microbiology of symptomatic LC in men post-robotic prostatectomy and PLND...
July 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28435202/phenotypic-and-genotypic-characterization-of-methicillin-resistant-staphylococcus-aureus-from-bovine-mastitis
#17
S Hamid, Mohd Altaf Bhat, Irfan Ahmad Mir, Anil Taku, Gulzar Ahmad Badroo, Salik Nazki, Andleeb Malik
AIM: This study was conducted to determine the occurrence of methicillin-sensitive and Staphylococcus aureus (MSSA) methicillin-resistant S. aureus (MRSA) from bovine mastitis and to characterize them with respect to antibiotic resistance gene mecA. MATERIALS AND METHODS: A total of 160 mastitic milk samples were screened for the presence of S. aureus. The presumptive positive isolates were confirmed using nuc and 23S rRNA gene-based polymerase chain reaction. All the confirmed isolates were subjected to in vitro antibiogram using a number of antibiotics...
March 2017: Veterinary World
https://www.readbyqxmd.com/read/28431478/successful-treatment-of-multidrug-resistant-acinetobacter-baumannii-meningitis-with-ampicillin-sulbactam-in-primary-hospital
#18
Leitao Sun, Xiaohong Wang, Zefu Li
INTRODUCTION: Acinetobacter baumannii nosocomial infections, especially those due to multi-drug resistant strains, are increasingly detected. We want to find the effective treatment measures about multi-resistant Acinetobacter baumannii infections through this research. METHODOLOGY: The clinical features and the outcomes of twelve cases of nosocomial Acinetobacter baumannii meningitis treated with ampicillin sulbactam and intrathecal use of amikacin are reported in primary hospital...
April 21, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28413685/empyema-associated-with-campylobacter-curvus-infection
#19
Yukihiro Horio, Yoshiki Shiraishi, Nobuo Watanabe, Shigeaki Inoue, Tadashi Imanishi, Koichiro Asano
We report the first case of thoracic empyema associated with Campylobacter curvus infection. A 65-year-old woman with a history of bronchiectasis presented with acute cough and phlegm. The patient reported dyspnoea and left chest pain accompanied by left pleural effusion, despite treatment with sitafloxacin. Curved Gram-negative rods, eventually identified as C. curvus using 16S ribosomal RNA- and atpA-specific polymerase chain reaction (PCR) and sequencing, were cultured in anaerobic condition of pleural effusion together with Peptostreptococci...
July 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28413506/active-efflux-pump-adeb-is-involved-in-multidrug-resistance-of-acinetobacter-baumannii-induced-by-antibacterial-agents
#20
Tingting Zhang, Min Wang, Yixin Xie, Xianping Li, Zhihui Dong, Yanhua Liu, Ling Wang, Min Yang, Huan Song, Hong Cao, Wei Cao
The aim of the present study was to investigate the resistance of Acinetobacter baumannii, which was induced by cefepime (FEP), cefoperazone-sulbactam (SCF), tazobactam (TZP), levofloxacin (LEV), amikacin (AK), imipenem (IPM), and ciprofloxacin (CIP), in vitro. Multi-step drug resistance selection of 16 A. baumannii strains was performed using seven antibacterial agents (FEP, TZP, CIP, AK, IPM, SCF, and LEV). The minimum inhibitory concentration (MIC) was determined using the agar dilution method. Random amplified polymorphic DNA polymerase chain reaction was performed to analyze the genotypes and the carrying rates of aac(3)-I, aac(6')-I, ant(3)-I, aph(3)-Via, OXA-23, OXA-24, AmpC, TEM-1, metallo-β-lactamase gene (IMP), armA, rmtA, rmtB, parC, gyrA and adeB...
April 2017: Experimental and Therapeutic Medicine
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