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Pre-transplant Recipient Evaluation in childrens

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https://www.readbyqxmd.com/read/27795988/sex-related-differences-in-the-risk-of-antibody-mediated-rejection-and-subsequent-allograft-vasculopathy-post-heart-transplantation-a-single-center-experience
#1
Avishay Grupper, Emilija M Nestorovic, Richard C Daly, Natasa M Milic, Lyle D Joyce, John M Stulak, David L Joyce, Brooks S Edwards, Naveen L Pereira, Sudhir S Kushwaha
BACKGROUND: Pregnancies may result in antibodies against HLA, a risk factor for antibody-mediated rejection (AMR) and subsequent cardiac allograft vasculopathy (CAV) after heart transplantation (HTx). The aim of this study was to evaluate sex differences in the incidence of AMR events and subsequent risk of CAV among HTx recipients. METHODS: The study comprised 160 patients (51 [32%] women) who underwent HTx in 2008 to 2014. The cumulative effect of AMR events was calculated by AMR score (sum of myocardial biopsy grading divided by number of biopsies taken during 3 years post-HTx)...
October 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27778091/delayed-graft-function-and-its-management-in-children
#2
Ryszard Grenda
Delayed graft function (DGF) is commonly defined as the requirement for dialysis within the first 7 days following renal transplantation. The major underlying mechanism is related to ischaemia/reperfusion injury, which includes microvascular inflammation and cell death and apoptosis, and to the regeneration processes. Several clinical factors related to donor, recipient and organ procurement/transplantation procedures may increase the risk of DGF, including donor cardiovascular instability, older donor age, donor creatinine concentration, long cold ischaemia time and marked body mass index of both the donor and recipient...
October 24, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27770258/kidney-transplantation-fails-to-provide-adequate-growth-in-children-with-chronic-kidney-disease-born-small-for-gestational-age
#3
Doris Franke, Rena Steffens, Lena Thomas, Leo Pavičić, Thurid Ahlenstiel, Lars Pape, Jutta Gellermann, Dominik Müller, Uwe Querfeld, Dieter Haffner, Miroslav Živičnjak
BACKGROUND: Children with chronic kidney disease are frequently born small for gestational age (SGA) and prone to disproportionately short stature. It is unclear how SGA affects growth after kidney transplantation (KTx). METHODS: Linear growth (height, sitting height, and leg length) was prospectively investigated in a cohort of 322 pediatric KTx recipients, with a mean follow-up of 4.9 years. Sitting height index (ratio of sitting height to total body height) was used to assess body proportions...
October 21, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27589263/evaluation-of-a-family-camp-intervention-for-children-with-a-heart-transplant-and-their-families
#4
David B Nicholas, Bernadette Dodd, Simon Urschel, Amber Young, Lori J West
Given the arduous course of heart transplantation and follow-up care, recipients and their families face complex challenges and stressors warranting supportive interventions. This study explored the impact of a family camp as an intervention of education and social support for pediatric transplant recipients and their families. A total of 49 individuals participated in this evaluation, including eight children and nine youth with heart transplants, five siblings, 19 parents, and 13 health care providers. Participants ranked and described the 3-day family camp experience...
October 2016: Social Work in Health Care
https://www.readbyqxmd.com/read/27485733/-safety-and-utility-of-percutaneous-liver-biopsy-in-hematopoietic-stem-cell-transplant-pediatric-recipients-a-retrospective-study
#5
Natalia Maximova, Massimo Gregori, Francesca Barbieri, Antonio Pizzol, Aurelio Sonzogni
BACKGROUND: Liver biopsies in pediatric hematopoietic stem cell transplantation (HSCT) patients are as and effective when performed at bedside in the Bone Marrow Transplant Unit (BMTU) than in the Day Surgery Unit (DSU), with better patient compliance and lower emotional distress for these children. METHODS: The study group consisted of 45 children who underwent allogeneic HSCT. We reviewed 68 liver biopsies performed between April 2006 and September 2015. 12 (17...
2016: BMC Cancer
https://www.readbyqxmd.com/read/26964698/outcomes-of-allogeneic-hematopoietic-cell-transplantation-in-children-and-young-adults-with-chronic-myeloid-leukemia-a-cibmtr-cohort-analysis
#6
Sonali Chaudhury, Rodney Sparapani, Zhen-Huan Hu, Taiga Nishihori, Hisham Abdel-Azim, Adriana Malone, Richard Olsson, Mehdi Hamadani, Andrew Daly, Ulrike Bacher, Baldeep M Wirk, Rammurti T Kamble, Robert P Gale, William A Wood, Gregory Hale, Peter H Wiernik, Shahrukh K Hashmi, David Marks, Celalettin Ustun, Reinhold Munker, Bipin N Savani, Edwin Alyea, Uday Popat, Ronald Sobecks, Matt Kalaycio, Richard Maziarz, Nobuko Hijiya, Wael Saber
Chronic myeloid leukemia (CML) in children and young adults is uncommon. Young patients have long life expectancies and low morbidity with hematopoietic cell transplantation (HCT). Prolonged tyrosine kinase inhibitor (TKI) use may cause significant morbidity. In addition, indication for HCT in patients in the first chronic phase is not established. We hence retrospectively evaluated outcomes in 449 CML patients with early disease receiving myeloablative HCT reported to the CIBMTR. We analyzed various factors affecting outcome, specifically the effect of age and pre-HCT TKI in pediatric patients (age < 18 years, n = 177) and young adults (age 18 to 29 years, n = 272) with the goal of identifying prognostic factors...
June 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/26910645/tacrolimus-predose-concentration-is-associated-with-hypertension-in-pediatric-liver-transplant-recipients
#7
Agnieszka Prytula, Kristof Vandekerckhove, Ann Raes, Daniel De Wolf, Jo Dehoorne, Johan Vande Walle, Ruth De Bruyne
BACKGROUND: The aim of the study was to analyze the incidence of hypertension in pediatric liver transplantation (LT) recipients using ambulatory blood pressure measurements (ABPM) and to identify factors associated with hypertension. We also investigated whether hypertension or tacrolimus predose concentration (TAC C0) was associated with increased left ventricular (LV) wall thickness. PATIENTS AND METHODS: On a retrospective longitudinal base, we included 39 pediatric LT recipients...
December 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/26636526/treatment-of-childhood-leukemia-with-haploidentical-hematopoietic-stem-cell-transplantation-using-parent-as-donor-a-single-center-study-of-111-case
#8
Y Sun, J Xiao, Z H Li, S F Fan, Y Shen
OBJECTIVE: In the present study, the outcomes of childhood leukemia treated with haplo-HSCT using parent as donor were evaluated and the risk factors for survival were identified. PATIENTS AND METHODS: 111 consecutive cases from March 2002 to March 2012 in our center were analyzed. The median age of patients was 10 (3-14) years old. All patients received unmanipulated combined marrow and peripheral blood stem cells for transplant after conditioning with busulfan and cyclophosphamide (Cy)/Cy and total body irradiation (TBI) plus antithymocyte globulin (ATG)...
November 2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26482350/the-role-of-medical-air-rescue-services-in-medical-transport-of-organ-recipients-in-poland-organizational-solutions-supporting-transplantation-medicine
#9
Robert Gałązkowski, Agata Pawlak, Daniel Rabczenko, Grzegorz Michalak, Michał M Farkowski, Roman Danielewicz, Maciej Sterliński
BACKGROUND: The aim of this study was to analyze the use of fixed-wing air ambulance (FWAA) services in Poland during the period 2012-2013, with particular emphasis on air transport of organ recipients to transplantation centers. MATERIAL AND METHODS: This was a retrospective, cross-sectional analysis of data derived from standard FWAA medical documentation. RESULTS: In the years 2012-2013 there were 500 emergency (52.7%) and 447 elective (47...
2015: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/26069765/chickenpox-infection-after-renal-transplantation
#10
Anupma Kaul, Raj K Sharma, Dharmendra Bhadhuria, Amit Gupta, Narayan Prasad
BACKGROUND: Chicken pox, although a common infection among children, is rare in immunocompromised patients, particularly renal transplant recipients, and carries a very high incidence of morbidity and mortality There is little data on chickenpox in adult renal transplant recipients, although reports have suggested that it may follow a virulent course requiring frequent hospitalization, and in severe cases can cause death. AIMS: To evaluate the incidence, severity and complications of a varicella/chickenpox infection in renal transplant recipients over 10 years follow-up...
June 2012: Clinical Kidney Journal
https://www.readbyqxmd.com/read/26024705/does-hypertension-remain-after-kidney-transplantation
#11
Gholamreza Pourmand, Sanaz Dehghani, Mohamad Reza Rahmati, Abdolrasoul Mehrsai, Shahram Gooran, Farimah Alizadeh, Siavash Khaki, Seyede Hamideh Mortazavi, Naghmeh Pourmand
Hypertension is a common complication of kidney transplantation with the prevalence of 80%. Studies in adults have shown a high prevalence of hypertension (HTN) in the first three months of transplantation while this rate is reduced to 50- 60% at the end of the first year. HTN remains as a major risk factor for cardiovascular diseases, lower graft survival rates and poor function of transplanted kidney in adults and children. In this retrospective study, medical records of 400 kidney transplantation patients of Sina Hospital were evaluated...
2015: Acta Medica Iranica
https://www.readbyqxmd.com/read/25994524/severe-neutropenia-in-children-after-renal-transplantation-incidence-course-and-treatment-with-granulocyte-colony-stimulating-factor
#12
Rachel Becker-Cohen, Efrat Ben-Shalom, Choni Rinat, Sofia Feinstein, Michael Geylis, Yaacov Frishberg
BACKGROUND: Infections are an important cause of morbidity and mortality in solid organ transplant recipients. Neutrophils play a crucial role in the initial host defense against bacterial pathogens. Neutropenia is not uncommon after renal transplantation in adults; however, there are scarce published data in children. We conducted a historical cohort study to evaluate the incidence, clinical course, and management of severe neutropenia after renal transplantation in children. METHODS: In a single-center study, we collected clinical and laboratory data on all children (<20 years) who underwent renal transplantation from January 2005 to March 2014...
November 2015: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/25624573/the-challenges-and-outcomes-of-living-donor-kidney-transplantation-in-pediatric-and-adolescent-age-group-in-a-developing-country-a-critical-analysis-from-a-single-center-of-north-india
#13
Aneesh Srivastava, Sandeep Prabhakaran, Sanjoy Kumar Sureka, Rakesh Kapoor, Anant Kumar, R K Sharma, Narayan Prasad, M S Ansari
INTRODUCTION: Renal transplantation is the treatment of choice for children with end-stage renal disease (ESRD). We evaluated the outcome of renal transplantation in the pediatric and adolescent age groups in the perspective of a developing country as compared with developed nations while highlighting the challenges we have faced in a pediatric transplant programme. MATERIALS AND METHODS: Seventy live related pediatric and adolescent renal transplantations were reviewed retrospectively...
January 2015: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/25319629/percutaneous-left-atrial-decompression-in-patients-supported-with-extracorporeal-membrane-oxygenation-for-cardiac-disease
#14
Lucas J Eastaugh, Ravi R Thiagarajan, Jeffrey R Darst, Doff B McElhinney, James E Lock, Audrey C Marshall
OBJECTIVES: Left atrial decompression using cardiac catheterization techniques has been described at centers with extracorporeal membrane oxygenation programs. Left atrial decompression can decrease cardiogenic edema, minimize ventricular distension, and allow myocardial recovery. We describe Boston Children's Hospital's experience with percutaneous left atrial decompression techniques, acute outcomes, and clinical impact of left atrial decompression in extracorporeal membrane oxygenation patients...
January 2015: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/24678028/health-related-quality-of-life-two-decades-after-liver-transplantation
#15
COMPARATIVE STUDY
Kara M Sullivan, David M Radosevich, John R Lake
In this study, we describe a cohort of patients who received liver transplants before January 1, 1989 at the University of Minnesota Medical Center (UMMC), and we evaluate the health-related quality of life (HRQOL) of the survivors of this group. One hundred sixty-one patients--66 adults and 95 children--received whole deceased donor liver transplants. Thirteen transplants occurred before 1980, and all these patients died within 6 months; they were excluded from the survival analysis because they came from the pre-cyclosporine era...
June 2014: Liver Transplantation
https://www.readbyqxmd.com/read/24495971/surgical-complications-and-graft-function-following-live-donor-extraperitoneal-renal-transplantation-in-children-20-kg-or-less
#16
Mohammed S ElSheemy, Ahmed M Shouman, Ahmed I Shoukry, Sherif Soaida, Doaa M Salah, Ali M Yousef, Hany A Morsi, Fatina I Fadel, Sameh Z Sadek
OBJECTIVES: To evaluate the effect of patient, surgical, and medical factors on surgical complications and graft function following renal transplantation (Tx) in children weighing ≤ 20 kg, because the number of this challenging group of children is increasing. PATIENTS AND METHODS: Between June 2009 and October 2013, 26 patients received living donor renal allotransplant using the extraperitoneal approach (EPA). The immunosuppression regimen was composed of prednisolone, mycophenolate mofetil, and ciclosporin or tacrolimus...
August 2014: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/24445407/hepatitis-e-in-liver-transplant-recipients-in-the-rh%C3%A3-ne-alpes-region-in-france
#17
C Buffaz, C Scholtes, A-G Dron, P Chevallier-Queyron, J Ritter, P André, C Ramière
PURPOSE: In developed countries, hepatitis E virus (HEV) is considered an emerging pathogen, but prevalence seems highly variable according to previous European studies. As HEV can lead to chronic infections in immunosuppressed patients, it is thus essential to evaluate the prevalence and incidence of this infection. METHODS: We determined retrospectively, in a cohort of 206 pediatric and adult liver transplant recipients from the Rhône-Alpes region in France, pre-transplant anti-HEV-IgG prevalence and incidence of HEV infections during post-transplant follow-up (HEV IgG and IgM ± HEV-RNA)...
June 2014: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/24164829/intra-operative-extracorporeal-membrane-oxygenation-use-in-pediatric-lung-transplantation-the-zurich-experience
#18
Alice J Zuercher, Ilhan Inci, Christian Benden, Gregory Fretz, Markus Béchir, Annette Boehler, Walter Weder
There is a lack of data regarding use of ECMO in children undergoing lung transplantation. We evaluated our experience of ECMO in pediatric lung transplant recipients. All patients (<18 yr) who underwent lung transplants between 1997 and 2011 were included (17 children; nine males; median age 16 yr), and the use of intra-operative ECMO evaluated. Transplant procedures were carried out with intra-operative ECMO in seven children (all bilateral lung transplants). Demographics of ECMO and non-ECMO patients were comparable...
December 2013: Pediatric Transplantation
https://www.readbyqxmd.com/read/24129123/priorities-for-cmv-vaccine-development
#19
REVIEW
Philip R Krause, Stephanie R Bialek, Suresh B Boppana, Paul D Griffiths, Catherine A Laughlin, Per Ljungman, Edward S Mocarski, Robert F Pass, Jennifer S Read, Mark R Schleiss, Stanley A Plotkin
A multidisciplinary meeting addressed priorities related to development of vaccines against cytomegalovirus (CMV), the cause of congenital CMV (cCMV) disease and of serious disease in the immunocompromised. Participants discussed optimal uses of a CMV vaccine, aspects of clinical study design, and the value of additional research. A universal childhood CMV vaccine could potentially rapidly reduce cCMV disease, as infected children are sources of viral transmission to seronegative and seropositive mothers. A vaccine administered to adolescents or adult women could also reduce cCMV disease by making them immune prior to pregnancy...
December 17, 2013: Vaccine
https://www.readbyqxmd.com/read/23769628/-development-of-psychological-and-intellectual-performance-in-transplanted-sickle-cell-disease-patients-a-prospective-study-from-pretransplant-period-to-5-years-after-hsct
#20
J Bockenmeyer, E Chamboredon, F Missud, M Benkerrou, L Holvoët, G Ithier, B Lescoeur, K Yakouben, M Ouachée-Chardin, P-S Rohrlich, M Duval, A Baruchel, J-H Dalle
RATIONALE: Allogeneic hematopoietic stem-cell transplantation (HSCT) is the only curative treatment for sickle cell disease (SCD). Cerebral vasculopathy was the principal indication for transplantation. These children could present impaired neuropsychological development related to different causes, hence the value of exploring their intellectual capacities before and after transplantation. MATERIAL AND METHODS: Prospective longitudinal study from 1992 to 2006 in all transplanted SCD patients...
July 2013: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
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