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https://www.readbyqxmd.com/read/29024079/the-preadolescent-acne-microbiome-a-prospective-randomized-pilot-study-investigating-characterization-and-effects-of-acne-therapy
#1
Carrie C Coughlin, Shane M Swink, Joseph Horwinski, Georgia Sfyroera, Julia Bugayev, Elizabeth A Grice, Albert C Yan
BACKGROUND/OBJECTIVES: Acne, a common pediatric disease, tends to be more comedonal in preadolescents, whereas older individuals are more likely to have inflammatory lesions in addition to comedones. Thus the microbiome of preadolescents may be different. In this pilot study we aimed to characterize the preadolescent acne microbiome, compare the microbiome in preadolescents with and without acne, and investigate changes in the microbiome after topical treatment with benzoyl peroxide or a retinoid in a small cohort of preadolescents...
October 11, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29023188/preliminary-experience-with-instillation-of-triamcinolone-acetonide-into-the-urethra-for-idiopathic-urethritis-a-prospective-pilot-study
#2
Junaid Ashraf, Anna R Radford, Alexander Turner, Ramnath Subramaniam
BACKGROUND: Idiopathic bulbar urethritis (IBU) is characterized by hematuria ± dysuria without infection. Symptoms result from inflammation of the bulbar urethra, distal to external sphincter. IBU is difficult to manage and there is no recommended therapy. OBJECTIVE: To determine whether instillation of triamcinolone acetonide is a useful treatment of IBU and its associated complications. SETTING AND PARTICIPANTS: Data were prospectively collected, for 22 months, on 14 consecutive patients presenting with terminal hematuria or blood spotting ± dysuria to a pediatric urology unit...
October 12, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29016845/pediatric-low-grade-gliomas-next-biologically-driven-steps
#3
David T W Jones, Mark W Kieran, Eric Bouffet, Sanda Alexandrescu, Pratiti Bandopadhayay, Miriam Bornhorst, David Ellison, Jason Fangusaro, Michael I Fisher, Nicholas Foreman, Maryam Fouladi, Darren Hargrave, Cynthia Hawkins, Nada Jabado, Maura Massimino, Sabine Mueller, Giorgio Perilongo, Antoinette Y N Schouten-van Meeteren, Uri Tabori, Katherine Warren, Angela J Waanders, David Walker, William Weiss, Olaf Witt, Karen Wright, Yuan Zhu, Daniel C Bowers, Stefan M Pfister, Roger J Packer
Despite the fact that they are not typically life-threatening, low-grade gliomas (LGGs) remain a significant clinical challenge in pediatric neurooncology due to co-morbidities associated with these tumors and/or their treatments, and their propensity to multiply recur. LGGs, in total the most common brain tumors arising in childhood, can often become a chronic problem requiring decades of management. The 2nd international consensus conference on pediatric low-grade gliomas held in Padua, Italy in 2016, was convened in an attempt to advance the pace of translating biological discoveries on LGGs into meaningful clinical benefit...
August 2, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28992320/effect-of-human-leukocyte-antigen-mismatching-on-the-outcomes-of-pediatric-kidney-transplantation-a-systematic-review-and-meta-analysis
#4
Xinmiao Shi, Rui Liu, Xinfang Xie, Jicheng Lv, Wenke Han, Xuhui Zhong, Jie Ding
Background: Kidney transplantation is regarded as the optimal treatment for pediatric patients with end-stage renal disease. Here, we address a controversial topic in pediatric kidney transplantation by performing a quantitative evaluation of the effect of human leukocyte antigen (HLA) mismatching on the outcomes of pediatric kidney transplantation. Methods: We systematically searched PubMed, EMBASE and the Cochrane Library from their inception to 31 December 2016 for cohort studies assessing the risk ratio (RR) of HLA mismatching on pediatric kidney transplantation...
August 23, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28991344/combined-oral-and-topical-beta-blockers-for-the-treatment-of-early-proliferative-superficial-periocular-infantile-capillary-hemangioma
#5
Hatem M Marey, Hesham F Elmazar, Sameh S Mandour, Hany A Khairy
PURPOSE: To evaluate the safety and efficacy of combined oral and topical beta blockers for the treatment of superficial periocular infantile hemangioma at the early proliferative stage. METHODS: This was a randomized, controlled comparison trial involving 25 patients. Patients were randomly enrolled into two groups: the topical and systemic treatment and systemic treatment only groups. The topical and systemic treatment group was treated with oral propranolol (1 mg/kg per day initially, increased to 2 mg/kg per day gradually in 2 weeks) and timolol maleate 0...
October 9, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28991343/endophthalmitis-following-pediatric-cataract-surgery-an-international-pediatric-ophthalmology-and-strabismus-council-global-perspective
#6
Almutez M Gharaibeh, Eedy Mezer, Luis H Ospina, Tamara Wygnanski-Jaffe
PURPOSE: To compile international data on the risk factors, diagnosis, and treatment of endophthalmitis following pediatric cataract surgery. METHODS: An e-mail containing a link to an online survey was sent to all members of the American Association for Pediatric Ophthalmology and Strabismus. The questionnaire examined the incidence, risk factors, treatment, outcomes, and prophylaxis of endophthalmitis following pediatric cataract surgery around the world. RESULTS: Two hundred thirty-seven ophthalmologists answered the questionnaire...
October 9, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28984477/pediatric-pharmacoepidemiology-safety-and-effectiveness-of-medicines-for-adhd
#7
Antonio Clavenna, Maurizio Bonati
Attention-deficit hyperactivity disorder (ADHD) is a common neurobehavioral disorder in children and adolescents that comprises core symptoms of developmentally inappropriate levels of inattention and/or hyperactivity and impulsivity. Stimulant (methylphenidate, amphetamines) and non stimulant (atomoxetine, clonidine and guanfacine) are the treatment usually prescribed for ADHD. Area covered: This review covers the safety of ADHD medications in children and adolescents. MEDLINE, EMBASE and PsycINFO databases were searched with the aim to retrieve prospective studies that monitored the incidence of adverse events (AEs) in children receiving drug therapy for ADHD...
October 6, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28983682/biliary-atresia-unity-in-diversity
#8
REVIEW
Claus Petersen
Biliary atresia (BA) is a rare disease of unknown origin and unsatisfying outcome. Single, multicenter and national evaluations of epidemiological and outcome data on BA have been periodically published over the course of decades. However, the diversity of the registered parameters and outcome measures impede comparability and cumulative analysis of these very worthwhile studies. Taking into account the fact that BA is a good example of translational research and transition of patients from pediatric surgery and hepatology to transplant surgery and hepatology in general, the interdisciplinary community should make every effort to develop a common platform upon which further activities are conducted...
October 5, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28983199/the-role-of-librarians-in-teaching-evidence-based-medicine-to-pediatric-residents-a-survey-of-pediatric-residency-program-directors
#9
Rachel Boykan, Robert M Jacobson
OBJECTIVE: The research sought to identify the general use of medical librarians in pediatric residency training, to define the role of medical librarians in teaching evidence-based medicine (EBM) to pediatric residents, and to describe strategies and curricula for teaching EBM used in pediatric residency training programs. METHODS: We sent a 13-question web-based survey through the Association of Pediatric Program Directors to 200 pediatric residency program directors between August and December 2015...
October 2017: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/28977339/glucocorticoid-induced-bone-disease-mechanisms-and-importance-in-pediatric-practice
#10
Emanuel Sávio Cavalcanti Sarinho, Verônica Maria Pinho Pessoa Melo
OBJECTIVE: To describe mechanisms by which glucocorticoids cause osteoporosis, with fracture risk, combining this learning with a possible professional behavior change. DATA SOURCES: A systematic search on SciELO, PubMed, Scopus, and Medline databases was carried out for consensus, review articles, including systematic reviews and meta-analysis, which were published in English, between 2000 and 2016. Keywords used on the search were the following: glucocorticoids, fractures, osteoporosis, bone health, vitamin D, children, and adolescents...
April 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/28976458/evaluation-of-the-c-mac-miller-video-laryngoscope-sizes-0-and-1-during-tracheal-intubation-of-infants-less-than-10-kg
#11
Florian J Raimann, Colleen E Cuca, Detlev Kern, Kai Zacharowski, Udo Rolle, Dirk Meininger, Christian F Weber, Christian Byhahn, Haitham Mutlak
STUDY OBJECTIVE: Video laryngoscopy has primarily been developed to assist in difficult airways. Using video laryngoscopy in pediatric airway management is an up-and-coming topic. The aim of the presented study was to compare the intubation conditions obtained when using the C-MAC video laryngoscope with Miller blades sizes 0 and 1 for standard direct laryngoscopy and indirect laryngoscopy in children weighing less than 10 kg. DESIGN: This was a prospective study...
October 2, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28974521/update-to-practice-standards-for-electrocardiographic-monitoring-in-hospital-settings-a-scientific-statement-from-the-american-heart-association
#12
REVIEW
Kristin E Sandau, Marjorie Funk, Andrew Auerbach, Gregory W Barsness, Kay Blum, Maria Cvach, Rachel Lampert, Jeanine L May, George M McDaniel, Marco V Perez, Sue Sendelbach, Claire E Sommargren, Paul J Wang
BACKGROUND AND PURPOSE: This scientific statement provides an interprofessional, comprehensive review of evidence and recommendations for indications, duration, and implementation of continuous electro cardiographic monitoring of hospitalized patients. Since the original practice standards were published in 2004, new issues have emerged that need to be addressed: overuse of arrhythmia monitoring among a variety of patient populations, appropriate use of ischemia and QT-interval monitoring among select populations, alarm management, and documentation in electronic health records...
October 3, 2017: Circulation
https://www.readbyqxmd.com/read/28973391/postoperative-epileptic-seizures-in-children-is-the-brain-incision-a-risk-factor
#13
Luca Massimi, Domenica Battaglia, Federico Bianchi, Simone Peraio, Elisabetta Peppucci, Concezio Di Rocco
BACKGROUND: Postoperative seizures (PSs) after neurosurgical operations are common but little is known about the role of surgical brain incision on their genesis. This topic has not been addressed so far. OBJECTIVE: To verify if the corticotomy affects the risk of PSs and postoperative epilepsy (PE) in children. METHODS: One hundred forty-three consecutive pediatric cases operated on for supratentorial lesions at the same institution in the last 15 yr have been retrospectively reviewed by dividing them into group A, 68 children who required brain corticotomy mainly for hemispheric tumors, and group B, 75 children treated through extracortical approaches mainly for suprasellar and optic tumors...
July 7, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28967843/children-s-aerobic-trainability-and-related-questions
#14
Raffy Dotan
In response to Armstrong's recent Special Topics review of "Top 10 Research Questions Related to Youth Aerobic Fitness," this commentary revisits some of the points raised, particularly in relation to the question of whether a child‒adult trainability difference does indeed exist. Discussed are the validity of much of the existing pediatric maximal oxygen consumption data upon which trainability conclusions are drawn, why differential trainability is likely a fact rather than a doubt, a reasoned novel approach to explaining the phenomenon, and how that explanation can bear upon and answer several of the other raised questions...
October 2, 2017: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/28967481/frameworks-for-evaluating-medicines-in-children
#15
REVIEW
Mark A Turner, Steven Hirschfeld
PURPOSE: To summarise contemporary approaches to evaluating medicines in children, emphasizing topics that are often misunderstood by one or more stakeholder groups. METHODS: A narrative review that integrates the literature with experience in multiple settings. FINDINGS: Children and young people need specific approaches to research about drugs because of growth and development. Specific approaches include practicalities such as the volume, frequency and technique of blood samples, and recruitment, including consent by proxy decision-makers and assent by children/young people...
September 26, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28965960/urinary-tract-infection-in-children-management-in-the-era-of-antibiotic-resistance-a-pediatric-urologist-s-view
#16
REVIEW
Balazs Kutasy, David Coyle, Magdalena Fossum
CONTEXT: Antibiotic resistance to uropathogens has grown significantly worldwide. Today, pediatric urologist experience a situation that needs appropriate action because urinary tract infections are one of the most common bacterial infections in children. OBJECTIVE: In this overview we aimed at presenting the clinical aspects of antibiotic usage in pediatric urology. Our intention was to take part of the important debate regarding future management of bacterial resistance against antibiotics...
September 28, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28961042/orbital-inflammatory-syndrome-and-anterior-uveitis-a-case-series
#17
Eric L Crowell, Alden K Bahr, Ore-Ofe O Adesina, Ankur A Kamdar, Kartik S Kumar, Alla Goldberg
PURPOSE: To describe four cases of orbital inflammatory syndrome (OIS) with associated anterior uveitis that have presented within 2 years to our practice. METHODS: Charts of patients diagnosed with OIS from June 2013 to May 2015 were reviewed. RESULTS: Four patients, three children and one adult, presented with orbital swelling, pain, and varying degrees of vision loss. Treatment with intravenous methylprednisolone resulted in significant symptomatic improvement in all cases initially; when symptoms recurred, the patients had evidence of anterior uveitis...
September 29, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28949953/effects-of-probiotics-on-experimental-necrotizing-enterocolitis-a-systematic-review-and-meta-analysis
#18
Gayatri Athalye-Jape, Shripada Rao, Sanjay Patole
BACKGROUND: Meta analyses of randomized controlled trials (RCTs) suggest that probiotics decrease the risk of necrotizing enterocolitis (NEC) in preterm infants. Many animal RCTs have evaluated probiotics for preventing NEC. We systematically reviewed the literature on this topic. METHODS: The protocol for systematic review of animal intervention studies (SYRCLE) was followed. Medline, Embase, ISI Web of Science, e-abstracts from the Pediatric Academic Society meetings and other neonatal conferences were searched in December 2015 and August 2016...
September 26, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28948431/vulvar-involvement-in-pediatric-crohn-s-disease-a-systematic-review
#19
REVIEW
Roberta Granese, Gloria Calagna, Giuliana Morabito, Carmine Carriero, Antonio Perino, Gabriele Tonni, Claudio Romano
PURPOSE: The aim of the study is to report a systematic review (from 2000 to 2017) of all pediatric cases of vulvar Crohn's disease (VCD) and to highlight the key-points for a correct diagnosis and management of this rare condition. METHODS: An electronic search using the Pubmed/Medline, Scopus, EMBASE, Cochrane database and Google Scholar database was performed according to PRISMA guidelines. RESULTS: Twenty pediatric studies and 22 cases of VCD were included for analysis...
September 25, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28947348/transition-from-pediatric-to-adult-care-by-young-adults-with-chronic-granulomatous-disease-the-patient-s-viewpoint
#20
Rachel Margolis, Lori Wiener, Maryland Pao, Harry L Malech, Steven M Holland, Patricia Driscoll
PURPOSE: Children with chronic illnesses are living longer, prompting health care provider attention to the transition from pediatric to adult care. Transition of care is successful when youth are independent in managing their health. The aims of this study were to identify the strengths and barriers to transition from pediatric to adult care and to determine strategies that could enhance the transition process. METHODS: A survey was administered via a structured interview to 33 young adult participants (19-27 years of age), living with chronic granulomatous disease all of whom transitioned from pediatric to adult care...
September 22, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
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