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https://www.readbyqxmd.com/read/27905316/recombination-dynamics-of-type-ii-excitons-in-ga-in-as-gaas-ga-as-sb-heterostructures
#1
S Gies, B Holz, C Fuchs, W Stolz, W Heimbrodt
(Ga,In)As/GaAs/Ga(As,Sb) multi-quantum well heterostructures have been investigated using continuous wave and time-resolved photoluminescence spectroscopy at various temperatures. A complex interplay was observed between the excitonic type-II transitions with electrons in the (Ga,In)As well and holes in the Ga(As,Sb) well and the type-I excitons in the (Ga,In)As and Ga(As,Sb) wells. The type-II luminescence exhibits a strongly non-exponential temporal behavior below a critical temperature of T c = 70 K. The transients were analyzed in the framework of a rate-equation model...
December 1, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27905024/potential-anti-genotoxic-effect-of-sodium-butyrate-to-modulate-induction-of-dna-damage-by-tamoxifen-citrate-in-rat-bone-marrow-cells
#2
Haidan M El-Shorbagy
Sodium butyrate (SB) is one of the histone deacetylase inhibitors (HDACi's) that is recently evidenced to have a prooxidant activity and an ability to reduce hydrogen peroxide-induced DNA damage. Since the majority of estrogen receptor positive breast cancer patients are treated with tamoxifen citrate (TC), which exerts well established oxidative and genotoxic effects, thus the basic objective of this study is to determine whether SB could ameliorate or curate tamoxifen citrate-induced oxidative DNA damage and genotoxic effect in vivo through up-regulation of some antioxidant enzymes...
November 30, 2016: Cytotechnology
https://www.readbyqxmd.com/read/27903395/-role-of-cytokine-matrix-metalloproteinase-axis-on-promoting-vascular-neointima-hyperplasia-in-mice
#3
Y Liu, W H Ning, X H Shen, D L Guo, L Guo
Objective: To observe the effects of tumor necrosis factor-α (TNF-α) and platelet derived growth factor (PDGF) on vascular neointimal hyperplasia on matrix metalloproteinase 9/2 gene knockout (MMP9/2(-/-)) mice and explore related mechanisms. Methods: Mice of control group, MMP9(-/-) group, MMP2(-/-) group and MMP9/2(-/-) group were studied. Femoral artery was injured by transluminal wire, the mRNA expression levels of TNF-α and PDGF on femoral artery were detected by RT-PCR; the protein expression of MMP9 and MMP2 were assessed by Western blot on day 0, 1, 3, 7, 14 and 28 post injury...
November 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27902902/history-of-the-first-generation-marek-s-disease-vaccines-the-science-and-little-known-facts
#4
Karel A Schat
Shortly after the isolation of Marek's disease (MD) herpesvirus (MDV) in the late 1960s vaccines were developed in England, the United States, and The Netherlands. Biggs and associates at the Houghton Poultry Research Station (HPRS) in England attenuated HPRS-16, the first cell-culture-isolated MDV strain, by passaging HPRS-16 in chick kidney cells. Although HPRS-16/Att was the first commercially available vaccine, it never became widely used and was soon replaced by the FC126 strain of herpesvirus of turkeys (HVT) vaccine developed by Witter and associates at the Regional Poultry Research Laboratory (now Avian Disease and Oncology Laboratory [ADOL]) in East Lansing, MI...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27900424/long-term-geochemical-evolution-of-lithogenic-versus-anthropogenic-distribution-of-macro-and-trace-elements-in-household-attic-dust
#5
Biljana Balabanova, Trajče Stafilov, Robert Šajn, Claudiu Tănăselia
Attic dusts were examined as historical archives of anthropogenic emissions, with the goal of elucidating the enrichment pathways associated with hydrothermal exploitation of Cu, Pb, and Zn minerals in the Bregalnica River basin in the eastern part of the Republic of Macedonia. Dust samples were collected from 84 settlements. Atomic emission spectrometry and mass spectrometry with inductively coupled plasma were applied as analytical techniques for the determination of 69 element contents. Multivariate analysis was applied for the extraction of dominant geochemical markers...
November 29, 2016: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27899068/title-role-of-matrix-metalloproteinase-9-in-progression-of-tuberculous-meningitis-a-pilot-study-in-patients-at-different-stages-of-the-disease
#6
S Majeed, P Singh, N Sharma, S Sharma
BACKGROUND: TBM (Tuberculous meningitis) is severe form of tuberculosis causing death of one third of the affected individuals or leaving two-third of the survivors disabled. MMP-9 (Matrix metalloproteinase-9) is produced by the central nervous system in a variety of inflammatory conditions and has a role in the breakdown of extracellular matrix and blood-brain barrier. METHODS: In this study, the levels of MMP-9 and its inhibitor, TIMP-1 (tissue inhibitor of metalloproteinases-1), were screened using zymography and reverse zymography in cerebrospinal fluid and serum of tuberculous meningitis patients at different stages of the disease...
November 29, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27893855/inhibition-of-matrix-metalloproteinase-9-enhances-rod-survival-in-the-s334ter-line3-retinitis-pigmentosa-model
#7
Jung-A Shin, Hwa Sun Kim, Andrew Vargas, Wan-Qing Yu, Yun Sung Eom, Cheryl Mae Craft, Eun-Jin Lee
Retinitis Pigmentosa (RP) is one of the most common forms of inherited visual loss with the initial degeneration of rod photoreceptors, followed by a progressive cone photoreceptor deterioration. Coinciding with this visual loss, the extracellular matrix (ECM) is reorganized, which alters matrix metalloproteinase (MMP) activity levels. A potential pathological role of MMPs, MMP-9 in particular, involves an excitotoxicity-mediated physiological response. In the current study, we examine the MMP-9 and MMP-2 expression levels in the rhodopsin S334ter-line3 RP rat model and investigate the impact of treatment with SB-3CT, a specific MMP-9 and MMP-2 inhibitor, on rod cell survival was tested...
2016: PloS One
https://www.readbyqxmd.com/read/27892835/effect-of-adhesive-restoration-and-bleaching-technique-on-the-concentration-of-hydrogen-peroxide-in-the-pulp-chamber
#8
V Cavalli, B G Silva, S B Berger, G Abuna, F C Marson, Cpm Tabchoury, M Giannini
This study aimed to quantify the concentration of hydrogen peroxide into the pulp chamber in the presence or absence of adhesive enamel restorations and to analyze the resin-dentin interface of bleached groups. Bovine incisors (120) were randomly divided into three groups according to enamel treatment (n=40 each): (1) enamel without restoration (control); (2) enamel cavities (3 mm diameter × 1.5 mm depth) restored with a silorane-based (SB) system; or (3) enamel cavities (3 mm diameter × 1.5 mm depth) restored with a dimethacrylate-based (DB) system...
November 28, 2016: Operative Dentistry
https://www.readbyqxmd.com/read/27891677/staurosporine-scaffold-based-rational-discovery-of-the-wild-type-sparing-reversible-inhibitors-of-egfr-t790m-gatekeeper-mutant-in-lung-cancer-with-analog-sensitive-kinase-technology
#9
Xiaoyun Song, Xingcai Liu, Xi Ding
The human epidermal growth factor receptor (EGFR) has been established as an attractive target for lung cancer therapy. However, an acquired EGFR T790M gatekeeper mutation is frequently observed in patients treated with first-line anticancer agents such as gefitinib and erlotinib to cause drug resistance, largely limiting the application of small-molecule kinase inhibitors in EGFR-targeted chemotherapy. Previously, the reversible pan-kinase inhibitor staurosporine and its several analogs such as Gö6976 and K252a have been reported to selectively inhibit the EGFR T790M mutant (EGFR(T790M) ) over wild-type kinase (EGFR(WT) ), suggesting that the staurosporine scaffold is potentially to develop the wild-type sparing reversible inhibitors of EGFR(T790M) ...
November 28, 2016: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/27890402/multi-elemental-analysis-of-human-lung-samples-using-inductively-coupled-plasma-mass-spectrometry
#10
Jackie Morton, Emma Tan, S Kim Suvarna
The aim of this study was to establish concentrations of a wide range of elements in human lung samples to allow better identification of potential exposures in subsequent cases. This study reports concentrations of 48 elements (Al, As, Au, B, Ba, Be, Bi, Br, Cd, Ce, Co, Cr, Cs, Cu, Fe, Ga, Gd, Ge, Hf, Hg, In, Li, Mn, Mo, Nb, Ni, Os, Pb, Pd, Pt, Rb, Re, Ru, Sb, Se, Sm, Sn, Sr, Ta, Te, Ti, Tl, Tm, V, W, Y, Zn and Zr) in fresh lung tissue samples from 54 hospital patients, of which 93% exhibited various forms of neoplasia...
November 19, 2016: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27889805/air-pollution-study-in-the-republic-of-moldova-using-moss-biomonitoring-technique
#11
Inga Zinicovscaia, Constantin Hramco, Octavian G Duliu, Konstantin Vergel, Otilia A Culicov, Marina V Frontasyeva, Gheorghe Duca
Moss biomonitoring using the species Hypnum cupressiforme (Hedw.) and Pleurocarpous sp was applied to study air pollution in the Republic of Moldova. A total of 41 elements (Na, Mg, Al, Cl, K, Ca, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Br, Rb, Sr, Zr, Cd, Sb, Cs, Ba, La, Ce, Nd, Sm, Eu, Gd, Tb, Tm, Yb, Hf, Ta, W, Pb, Th, and U) were determined by instrumental epithermal neutron activation analysis and atomic absorption spectrometry. Principal component analysis was used to identify and characterize different pollution sources...
November 26, 2016: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27889660/the-ph-dependent-leaching-behavior-of-slags-from-various-stages-of-a-copper-smelting-process-environmental-implications
#12
Alice Jarošíková, Vojtěch Ettler, Martin Mihaljevič, Bohdan Kříbek, Ben Mapani
The leaching behaviors of primary copper (Cu) slags originating from Ausmelt, reverbatory, and converter furnaces operating under a single technological process were compared to a residual slag tailing obtained by slag re-processing via flotation and metal recovery. The EN 12457-2 leaching test, used for assessment of the hazardous properties, was followed by the CEN/TS 14997 pH-static leaching test (pH range 3-12). Both leaching experiments were coupled with a mineralogical investigation of the primary and secondary phases as well as geochemical modeling...
November 24, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27888747/disconfirming-contamination-related-threat-beliefs-by-exposure-plus-safety-behavior
#13
Sophie L van Uijen, Marcel A van den Hout, Anne T Klein Schiphorst, Emma S Knol, Iris M Engelhard
BACKGROUND AND OBJECTIVES: Safety behavior (SB) is detrimental to the beneficial effects of exposure, because it prevents patients from obtaining evidence that disconfirms their excessive threat beliefs. However, previous studies showed that cleaning SB during exposure to a contaminant does not prevent a reduction in feelings of contamination, fear of contamination, danger, and disgust (CFDD). We aimed to directly examine the effect of SB during exposure to a contaminant on threat beliefs associated with CFDD...
November 16, 2016: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/27887954/the-short-chain-fatty-acid-sodium-butyrate-functions-as-a-regulator-of-the-skin-immune-system
#14
Agatha Schwarz, Anika Bruhs, Thomas Schwarz
There is evidence that gut commensal microbes affect the mucosal immune system via expansion of regulatory T cells (Treg) in the colon. This is mediated via short-chain fatty acids (SCFA), bacterial metabolites generated during fiber fermentation, which include butyrate, propionate and acetate. We postulated that SCFA produced by commensal skin bacteria may also activate resident skin Treg, the activity of which is diminished in certain inflammatory dermatoses. Sodium butyrate (SB) either injected s.c. or applied topically onto the ears of hapten-sensitized mice significantly reduced the contact hypersensitivity reaction...
November 22, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27886620/pet-measurement-of-gaba-shift-in-the-rat-brain-a-preclinical-application-of-bolus-plus-constant-infusion-paradigm-of-18-f-flumazenil
#15
Wook Kim, Hyun Soo Park, Byung Seok Moon, Byung Chul Lee, Sang Eun Kim
INTRODUCTION: We measured the tiagabine-induced enhancement of the GABAA receptor's affinity for benzodiazepine ligands ("GABA shift") using [(18)F]flumazenil (FMZ) PET with preclinical application of bolus plus constant infusion (B/I). Differences in quantified results of [(18)F]FMZ binding were compared to that of [(18)F]FMZ PET with single bolus injection (SB). MATERIALS AND METHODS: Sprague-Dawley rats underwent [(18)F]FMZ PET scans with B/I, which consisted of baseline and "GABA shift" sessions in a scan, or scans with SB one week apart...
November 4, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27885579/an-integrated-assessment-of-pollution-and-biological-effects-in-flounder-mussels-and-sediment-in-the-southern-baltic-sea-coastal-area
#16
Henryka Dabrowska, Orest Kopko, Kari K Lehtonen, Thomas Lang, Ilona Waszak, Maija Balode, Evita Strode
Organic and metal contaminants and biological effects were investigated in flounder, mussels, and sediments in the southern Baltic Sea coastal area in order to assess environmental quality status in that area. Four sites were selected, including two within the Gulf of Gdańsk (GoG). In biota and sediment at each site, DDTs dominated over PCBs and PBDEs were the least abundant among organic contaminants. Their concentrations decreased progressively outward from GoG. Among metal contaminants, the levels of Hg, Pb, and Cd were elevated in GoG...
November 24, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27884113/disrupting-ros-protection-mechanism-allows-hydrogen-peroxide-to-accumulate-and-oxidize-sb-iii-to-sb-v-in-pseudomonas-stutzeri-ts44
#17
Dan Wang, Fengqiu Zhu, Qian Wang, Christopher Rensing, Peng Yu, Jing Gong, Gejiao Wang
BACKGROUND: Microbial antimonite [Sb(III)] oxidation converts toxic Sb(III) into less toxic antimonate [Sb(V)] and plays an important role in the biogeochemical Sb cycle. Currently, little is known about the mechanisms underlying bacterial Sb(III) resistance and oxidation. RESULTS: In this study, Tn5 transposon mutagenesis was conducted in the Sb(III)-oxidizing strain Pseudomonas stutzeri TS44 to isolate the genes responsible for Sb(III) resistance and oxidation...
November 25, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27882611/chronic-lactate-supplementation-does-not-improve-blood-buffering-capacity-and-repeated-high-intensity-exercise
#18
L F Oliveira, V de Salles Painelli, K Nemezio, L S Gonçalves, G Yamaguchi, B Saunders, B Gualano, G G Artioli
Since there is conflicting data on the buffering and ergogenic properties of calcium lactate (CL), we investigated the effect of chronic CL supplementation on blood pH, bicarbonate, and high-intensity intermittent exercise performance. Sodium bicarbonate (SB) was used as a positive control. Eighteen athletes participated in this double-blind, placebo-controlled, crossover, fully counterbalanced study. All participants underwent three different treatments: placebo (PL), CL, and SB. The dose was identical in all conditions: 500 mg/kg BM divided into four daily individual doses of 125 mg/kg BM, for five consecutive days, followed by a 2-7-day washout period...
November 23, 2016: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/27878175/synergistic-effects-of-mining-and-urban-effluents-on-the-level-and-distribution-of-methylmercury-in-a-shallow-aquatic-ecosystem-of-the-bolivian-altiplano
#19
L Alanoca, S Guédron, D Amouroux, S Audry, M Monperrus, E Tessier, S Goix, D Acha, P Seyler, D Point
Lake Uru Uru (3686 m a.s.l.) located in the Bolivian Altiplano region receives both mining effluents and urban wastewater discharges originating from the surrounding local cities which are under rapid development. We followed the spatiotemporal distribution of different mercury (Hg) compounds and other metal(oid)s (e.g., Fe, Mn, Sb, Ti and W) in both water and sediments during the wet and dry seasons along a north-south transect of this shallow lake system. Along the transect, the highest Hg and metal(oid) concentrations in both water and sediments were found downstream of the confluences with mining effluents...
November 23, 2016: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/27877860/facile-preparation-of-acid-resistant-magnetite-particles-for-removal-of-sb-%C3%A2-from-strong-acidic-solution
#20
Dong Wang, Kaiwen Guan, Zhiping Bai, Fuqiang Liu
A new facile coating strategy based on the hydrophobicity of methyl groups was developed to prevent nano-sized magnetite particles from strong acid corrosion. In this method, three steps of hydrolysis led to three layers of protection shell coating Fe3O4 nanoparticles. Filled with hydrophobic methyl groups, the middle layer mainly prevented the magnetic core from strong acid corrosion. These magnetite particles managed to resist 1 M HCl solution and 2.5 M H2SO4 solution. The acid resistant ability was higher than those reported previously...
2016: Science and Technology of Advanced Materials
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