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https://www.readbyqxmd.com/read/28712906/a-comparison-of-pharmacologic-therapeutic-agents-used-for-the-reduction-of-intracranial-pressure-following-traumatic-brain-injury
#1
REVIEW
Ahmed M Alnemari, Brianna M Krafcik, Tarek R Mansour, Daniel Gaudin
OBJECTIVE: In neurotrauma care, a better understanding of treatments following traumatic brain injury (TBI) has led to a significant decrease in morbidity and mortality in this population. TBI represents a significant medical problem, and complications following TBI are associated with the initial injury and post-event intracranial processes such as elevated intracranial pressure (ICP) and brain edema. Consequently, appropriate therapeutic interventions are required to reduce brain tissue damage and improve cerebral perfusion...
July 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28678332/effect-of-different-blood-glucose-intervention-plans-on-elderly-people-with-type-2-diabetes-mellitus-combined-with-dementia
#2
Y Chen, J Wang, L-J Wang, H Lin, P-J Huang
OBJECTIVE: We analyzed the effects of intensive and mitigatory blood glucose control strategy on elderly people with type 2 diabetes mellitus (T2DM) combined with Alzheimer disease (AD). PATIENTS AND METHODS: We enrolled 90 elderly patients with T2DM combined with AD to participate in this study. They were randomly divided into 3 groups: the control group, the strength group and the mitigation group with 30 cases in each group. In the control group, patients were only treated with diet and exercise while in the strength group patients were treated with oral hypoglycemic medications, subcutaneous insulin infusion or continuous infusion by micropump...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28596470/-epidural-emphysema-associated-with-diabetic-nonketotic-hyperosmolar-coma
#3
Yoshinari Takaya, Tomoyuki Uchiyama, Shunichi Murano
No abstract text is available yet for this article.
June 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28570329/endocrine-emergencies-with-neurologic-manifestations
#4
Makoto Ishii
PURPOSE OF REVIEW: This article provides an overview of endocrine emergencies with potentially devastating neurologic manifestations that may be fatal if left untreated. Pituitary apoplexy, adrenal crisis, myxedema coma, thyroid storm, acute hypercalcemia and hypocalcemia, hyperglycemic emergencies (diabetic ketoacidosis and hyperglycemic hyperosmolar state), and acute hypoglycemia are discussed, with an emphasis on identifying the signs and symptoms as well as diagnosing and managing these clinical entities...
June 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28393586/evaluation-of-glycated-albumin-ga-and-ga-hba1c-ratio-for-diagnosis-of-diabetes-and-glycemic-control-a-comprehensive-review
#5
Sara Yazdanpanah, Mohammad Rabiee, Mohammadreza Tahriri, Mojgan Abdolrahim, Asadollah Rajab, Hossein E Jazayeri, Lobat Tayebi
Diabetes Mellitus (DM) is a group of metabolic diseases characterized by chronic high blood glucose concentrations (hyperglycemia). When it is left untreated or improperly managed, it can lead to acute complications including diabetic ketoacidosis and non-ketotic hyperosmolar coma. In addition, possible long-term complications include impotence, nerve damage, stroke, chronic kidney failure, cardiovascular disease, foot ulcers, and retinopathy. Historically, universal methods to measure glycemic control for the diagnosis of diabetes included fasting plasma glucose level (FPG), 2-h plasma glucose (2HP), and random plasma glucose...
April 10, 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/28324468/ascariasis-and-hyperosmolar-hyperglycemic-state-a-surprising-ultrasound-finding-in-the-emergency-department
#6
Giles N Cattermole, Jean-Paul Nzabandora
BACKGROUND: We report the ultrasound finding of ascariasis in a patient with hyperosmolar hyperglycemic state (HHS). Although ascariasis is common in low-resource settings, there has been no previous report associating ascariasis with HHS. CASE PRESENTATION: A 26-year-old Rwandan man was admitted to the emergency department in coma, with a glycemia of 600 mg/dl. He was resuscitated with fluids, intubated and ventilated, and treated with insulin and antibiotics...
December 2017: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28320579/-acute-necrotising-oesophagitis-associated-with-hyperosmolar-diabetic-coma
#7
J Mostazo-Torres, M Vílchez-Jaimez, D Marín-García
No abstract text is available yet for this article.
March 17, 2017: Semergen
https://www.readbyqxmd.com/read/27896327/a-case-of-mediastinitis-accompanied-with-hyperosmolar-nonketotic-coma
#8
Mazhar Muslum Tuna, Faruk Kilinc, Zafer Pekkolay, Hikmet Soylu, Alpaslan Kemal Tuzcu
Mediastinitis is a serious infection involving mediastinal spaces after cervical infections spread along the facial planes. A late diagnosis of mediastinitis may result in death. Here we present a diabetic patient suffered from mediastinit accompanied with hyperosmolar nonketotic coma. A 61 years old male patient with type 2 diabetes was admitted to our hospital, with complaint of generalized worsening and fever. A diagnosis of nonketotic hyperosmolar coma was done and proper treatment started immediately. Neck tomography revealed abscess formation in the upper mediastinum...
June 2016: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27851592/1958-unique-survival-story-of-hyperosmolar-coma-due-to-huge-co-ingestion-of-ethylene-glycol-and-ethanol
#9
Jessita S Natasha Albert Messiah Dhas, Raghad Hussein, Mohammed Mogri, Lokendra Thakur
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27695597/continuous-qualitative-electroencephalography-as-a-noninvasive-neuromonitor
#10
Zachary D Threlkeld, Mohan Kottapally, Aimee Aysenne, Nerissa Ko
Intracranial pressure (ICP) monitoring frequently guides key decisions in the management of diseases causing intracranial hypertension. Although typically measured by invasive means, contraindications may leave the clinician with little recourse for dynamic ICP evaluation-particularly when the patient's mental status is compromised. We describe here a healthy 18-year-old woman who subacutely progressed to coma due to diffuse cerebral venous sinus thrombosis. Heparinization precluded the use of invasive ICP monitoring, and electroencephalography (EEG) was used novelly as a surrogate ICP monitor...
October 2016: Neurohospitalist
https://www.readbyqxmd.com/read/27632060/intracranial-pressure-monitoring-in-infants-and-young-children-with-traumatic-brain-injury
#11
Rebecca R Dixon, Maryalice Nocera, Adam J Zolotor, Heather T Keenan
OBJECTIVE: To examine the use of intracranial pressure monitors and treatment for elevated intracranial pressure in children 24 months old or younger with traumatic brain injury in North Carolina between April 2009 and March 2012 and compare this with a similar cohort recruited 2000-2001. DESIGN: Prospective, observational cohort study. SETTING: Twelve PICUs in North Carolina. PATIENTS: All children 24 months old or younger with traumatic brain injury, admitted to an included PICU...
November 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27625237/is-intracranial-pressure-monitoring-useful-in-children-with-severe-traumatic-brain-injury
#12
Sekar Arunkumar, Bhagavatula Indira Devi, Dhaval Shukla, Madhusudhan Reddy
BACKGROUND: Intracranial pressure monitoring (ICP) is considered as optional for management of severe traumatic brain injury (TBI) in children. AIMS: This study was performed to determine whether ICP monitoring is beneficial in the managing severe TBI in children. SETTINGS AND DESIGN: Neurosurgical intensive care unit (ICU) of a tertiary care referral center; prospective observational study. MATERIALS AND METHODS: Children aged 16 years or less with severe TBI defined as "postresuscitation Glasgow Coma Scale (GCS) score of 8 or less admitted to an ICU" were enrolled...
September 2016: Neurology India
https://www.readbyqxmd.com/read/27568371/hyperosmolar-therapy-in-pediatric-traumatic-brain-injury-a-retrospective-study
#13
Nadia Roumeliotis, Christian Dong, Géraldine Pettersen, Louis Crevier, Guillaume Emeriaud
OBJECTIVES: The objectives of the study are to describe the use of hyperosmolar therapy in pediatric traumatic brain injury (TBI) and examine its effect on intracranial pressure (ICP) and cerebral perfusion pressure (CPP). DESIGN: A retrospective review of patients with severe TBI admitted to the pediatric intensive care unit (PICU) was conducted. Inclusion criteria were ICP monitoring and administration of a hyperosmolar agent (20 % mannitol or 3 % hypertonic saline) within 48 h of PICU admission; for which dose and timing were recorded...
December 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/26679969/demographic-and-clinical-profiles-of-type-2-diabetes-mellitus-patients-initiating-canagliflozin-versus-dpp-4-inhibitors-in-a-large-u-s-managed-care-population
#14
COMPARATIVE STUDY
Michael Grabner, Xiaomei Peng, Caroline Geremakis, Jay Bae
BACKGROUND: Canagliflozin is the first sodium-glucose co-transporter-2 (SGLT-2) inhibitor-a new class of oral antidiabetic (OAD) medication-approved for type 2 diabetes mellitus (T2DM) treatment in the United States. Approved less than 2 years ago, use of canagliflozin is largely uncharacterized. OBJECTIVE: To investigate and compare baseline demographic, clinical, and economic characteristics of patients initiating canagliflozin and dipeptidyl peptidase-4 (DPP-4) inhibitors in the real-world setting...
December 2015: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/26169976/-successful-treatment-of-extreme-hypernatremia-by-continuous-veno-venous-hemodiafiltration
#15
Mikhael Giabicani, Pierre-Gildas Guitard, Dominique Guerrot, Steven Grangé, Lauranne Teule, Bertrand Dureuil, Benoît Veber
Extreme hypernatremia in intensive care unit are frequently associated with a poor prognosis and their treatment, when associated with acute renal failure, is not consensual. We report the case of a 39-year-old man admitted in our intensive care unit for coma who presented extreme hyperosmolar hypernatremia (sodium 180 mmol/L, osmolarity 507 mOsm/L) associated with acute renal failure (urea 139.3 mmol/L, creatinine 748 μmol/L) and many other metabolic abnormalities. He was treated with hypotonic fluid administration and continuous renal replacement therapy (veno-venous hemodiafiltration) using an industrial dialysate fluid...
November 2015: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/26148702/hyperosmolar-coma-in-a-patient-with-hypothalamic-langerhans-cell-histiocytosis
#16
LETTER
Ivan Kruljac, Goran Rinčić, Hrvoje Ivan Pećina
No abstract text is available yet for this article.
April 2016: Endocrine
https://www.readbyqxmd.com/read/26082293/efficacy-and-safety-of-continuous-micro-pump-infusion-of-3-hypertonic-saline-combined-with-furosemide-to-control-elevated-intracranial-pressure
#17
Yuqian Li, Zhihong Li, Min Li, Yanlong Yang, Bao Wang, Li Gao, Xingye Zhang, Hongyu Cheng, Wei Fang, Bo Zhao, Boliang Wang, Guodong Gao, Lihong Li
BACKGROUND: Elevated intracranial pressure is one of the most common problems in patients with diverse intracranial disorders, leading to increased morbidity and mortality. Effective management for increased intracranial pressure is based mainly on surgical and medical techniques with hyperosmolar therapy as one of the core medical treatments. The study aimed to explore the effects of continuous micro-pump infusions of 3% hypertonic saline combined with furosemide on intracranial pressure control...
2015: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/26054632/the-prevalence-and-impact-of-hyperglycemia-and-hyperlipidemia-in-patients-with-advanced-cancer-receiving-combination-treatment-with-the-mammalian-target-of-rapamycin-inhibitor-temsirolimus-and-insulin-growth-factor-receptor-antibody-cixutumumab
#18
MULTICENTER STUDY
Naifa L Busaidy, Patricia LoRusso, Kristie Lawhorn, Kenneth R Hess, Mohammed Amir Habra, Siqing Fu, David S Hong, Helen X Chen, Lawrence A Doyle, Razelle Kurzrock, Aung Naing
BACKGROUND: Cixutumumab (a humanized monoclonal antibody against insulin-like growth factor-1 receptor [IGF-1R]) and the mammalian target of rapamycin (mTOR) inhibitor temsirolimus were combined in a phase I study of patients with advanced cancer. We investigated the prevalence of metabolic toxicities, their management, and impact on outcome. METHODS: The temsirolimus dose was 25 mg or 37.5 mg i.v. weekly with escalating doses of cixutumumab (3, 5, or 6 mg/kg i...
July 2015: Oncologist
https://www.readbyqxmd.com/read/26013782/diabetes-mellitus-and-ramadan-in-elderly-patients
#19
Said Azzoug, Souad Mahgoun, Farida Chentli
Worldwide, the proportion of people above 60 years old represents 15% of the whole population. Diabetes mellitus is more frequent in this age group, and is associated with increased risk of morbidities and premature mortality. Aged Muslim people with diabetes insist on fasting during Ramadan, for many reasons. Elderly people, especially frail patients, who fast are at increased risk for many complications such as hypoglycaemia, hyperglycaemia and metabolic decompensation including hyperosmolar coma, diabetic ketoacidosis, dehydration and thrombosis...
May 2015: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/25966070/promotive-effect-of-comprehensive-management-on-achieving-blood-glucose-control-in-senile-type-2-diabetics
#20
S-T Yan, C-X Li, C-L Li, J Li, Y-H Shao, Y Liu, W-W Zhong, F-S Fang, B-R Sun, H Tian
The aim of this study was to evaluate the control of blood glucose and glycosylated hemoglobin A1c (HbA1c) and its influencing factors, in elderly type 2 diabetic mellitus (T2DM) patients undergoing comprehensive management. After years of comprehensive prevention of and control measures for diabetes, elderly T2DM patients who were receiving long-term health care were comprehensively evaluated through an annual physical examination. In addition to routine health examination, the patients were required to undergo HbA1c measurement...
2015: Genetics and Molecular Research: GMR
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