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https://www.readbyqxmd.com/read/29793054/bacillus-clausii-inhibits-bone-loss-by-skewing-treg-th17-cell-equilibrium-in-postmenopausal-osteoporotic-mice-model
#1
Hamid Y Dar, Subhashis Pal, Prashant Shukla, Pradyumna K Mishra, Geetanjali B Tomar, Naibedya Chattopadhyay, Rupesh K Srivastava
OBJECTIVES: Postmenopausal osteoporosis is one of most commonly occurring skeletal diseases leading to bone loss and fragility. Probiotics have been associated with various immunomodulatory properties and thus can be exploited to enhance bone health. In the present study, we report, to our knowledge for the first time, that oral administration of Bacillus clausii (BC) in postmenopausal osteoporotic (OVX) mice model enhances bone health. METHODS: BC was selected as probiotic of choice due to its established immunomodulatory properties...
March 20, 2018: Nutrition
https://www.readbyqxmd.com/read/29793000/effect-of-a-bisphosphonate-and-selective-estrogen-receptor-modulator-on-bone-remodeling-in-streptozotocin-induced-diabetes-and-ovariectomized-rat-model
#2
Young-Seok Lee, Rishab Gupta, Jeong-Taik Kwon, Dae-Chul Cho, Ye Jin Seo, Sung Young Seu, Eui Kyun Park, Inbo Han, Chi-Heon Kim, Joo-Kyung Sung, Kyoung-Tae Kim
BACKGROUND CONTEXT: Diabetes and menopause can cause severe osteoporosis. In general, menopause and diabetes can lead to an imbalance in bone turnover, which results in secondary osteoporosis. However, the efficacy of antiresorptive drugs against this form of osteoporosis has not been extensively evaluated. OBJECTIVE: The aim of this study was to determine the changes in vertebral bone remodeling when postmenopausal osteoporosis is accompanied by diabetes and the efficacy of bisphosphonates and selective estrogen-receptor modulators (SERMs) against these outcomes...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792998/bmi-and-gender-increase-risk-for-sacral-fractures-after-multilevel-instrumented-spinal-fusion-compared-to-bone-mineral-density-and-pelvic-parameters
#3
Stephan N Salzmann, Courtney Ortiz Miller, John A Carrino, Jingyan Yang, Jennifer Shue, Andrew A Sama, Frank P Cammisa, Federico P Girardi, Alexander P Hughes
BACKGROUND CONTEXT: Sacral fractures are a rare but potentially devastating complication. Long-fusion constructs including the sacrum that do not extend to the pelvis may result in sacral fractures. Besides established risk factors including gender, age and number of levels fused, body mass index (BMI), pelvic parameters and bone mineral density (BMD) have also been proposed as potential risk factors for postoperative sacral fractures. The literature supporting this, however, is limited...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792544/synergistic-phytochemicals-fail-to-protect-against-ovariectomy-induced-bone-loss-in-rats
#4
Suresh Ambati, Colette N Miller, Erica F Bass, Natalie M Hohos, Diane L Hartzell, Emily W Kelso, Emily R Trunnell, Jeong-Yeh Yang, Mary Anne Della-Fera, Clifton A Baile, Srujana Rayalam
Menopause induces a loss of bone as a result of estrogen deficiency. Despite pharmaceutical options for the treatment of osteopenia and osteoporosis, many aging women use dietary supplements with estrogenic activity to prevent bone loss and other menopausal-related symptoms. Such supplements are yet to be tested for efficacy against a Food and Drug Administration (FDA) approved medication for menopausal bone loss such as zoledronic acid (ZA). The postmenopausal rat model was used to investigate the efficacy of various synergistic phytochemical blends mixed into the diet for 16 weeks...
May 24, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29792069/maternal-nutrition-and-the-developmental-origins-of-osteoporosis-in-offspring-potential-mechanisms-and-clinical-implications
#5
Jia Zheng, Qianyun Feng, Sheng Zheng, Xinhua Xiao
Osteoporosis, the most frequent metabolic disorder of bone, is a complex disease with a multifactorial origin that is influenced by genes and environments. However, the pathogenesis of osteoporosis has not been fully elucidated. The theory of "Developmental Origins of Health and Disease" indicates that early life environment exposure determines the risks of cardiometabolic diseases in adulthood. However, investigations into the effects of maternal nutrition and nutrition exposure during early life on the development of osteoporosis are limited...
January 1, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29790567/regional-diversity-in-the-murine-cortical-vascular-network-is-revealed-by-synchrotron-x-ray-tomography-and-is-amplified-with-age
#6
J A Núñez, A Goring, B Javaheri, H Razi, D Gomez-Nicola, A A Pitsillides, P J Thurner, D Gomez-Nicola, P Schneider, C E Clarkin
TCortical bone is permeated by a system of pores, occupied by the blood supply and osteocytes. With ageing, bone mass reduction and disruption of the microstructure are associated with reduced vascular supply. Insight into the regulation of the blood supply to the bone could enhance the understanding of bone strength determinants and fracture healing. Using synchrotron radiation-based computed tomography, the distribution of vascular canals and osteocyte lacunae was assessed in murine cortical bone and the influence of age on these parameters was investigated...
May 23, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29790498/rooibos-tea-extracts-inhibit-osteoclast-formation-and-activity-through-the-attenuation-of-nf-%C3%AE%C2%BAb-activity-in-raw264-7-murine-macrophages
#7
Shaakirah Moosa, Abe E Kasonga, Vishwa Deepak, Sumari Marais, Innocentia B Magoshi, Megan J Bester, Marlena C Kruger, Magdalena Coetzee
Rooibos tea is a naturally sweet and aromatic tea that is native to the Western Cape province of South Africa. Rooibos is usually fermented to produce the traditional reddish brown colour and has been found to have numerous health benefits. These include beneficial effects on osteoblasts; however, its effects on osteoclast formation and activity are unknown. Osteoclasts are large, multinucleated cells responsible for bone resorption. Binding of RANKL to its receptor on osteoclast precursors triggers the NF-κB signalling pathway leading to the formation of osteoclasts...
May 23, 2018: Food & Function
https://www.readbyqxmd.com/read/29790378/effect-of-hwnt10b-transgene-overexpression-on-peri-implant-osteogenesis-in-ovariectomized-rats
#8
Hanghang Liu, Nian Zhang, Yao Liu, Li Liu, Guozhu Yin, En Luo
Purpose This study aims to investigate the efficacy of human Wnt10b (hWnt10b) transgene in accelerating osseointegration around titanium implant in ovariectomized (OVX) rats, and to provide a new strategy for implant treatment of osteoporotic patients. Methods In vivo, osteoporosis rat model was constructed by bilateral ovariectomy and the expression change of Wnt pathway related genes was investigated. Then Ad-hWnt10b was locally administered to the femur defect prior to implant placement in OVX rats, surrounding femur tissues were collected 1 and 3 weeks respectively after implantation for imaging, biomechanical test, molecular and histological analysis...
May 23, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29790021/the-effect-of-cholecystectomy-on-25-hydroxyvitamin-d-levels-and-bone-mineral-density-in-postmenopausal-women
#9
Hatice Beyazal Polat, Munevver Serdaroglu Beyazal
Vitamin D deficiency has been reported in patients with gastrointestinal disorders. Little is known on the potentially deleterious effect of cholecystectomy on vitamin D levels and osteoporosis. We found that 25-hydroxyvitamin D levels and bone mineral density were lower in patients with prior cholecystectomy. PURPOSE: The influence of bile salts on vitamin D absorption is well-known, and increased incidence of vitamin D deficiency has been reported in patients with gastrointestinal disorders...
May 22, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29789783/mir-142-5p-in-bone-marrow-derived-mesenchymal-stem-cells-promotes-osteoporosis-involving-targeting-adhesion-molecule-vcam-1-and-inhibiting-cell-migration
#10
Zhaowei Teng, Xueguan Xie, Yun Zhu, Jianping Liu, Xingbo Hu, Qiang Na, Xiongwen Zhang, Guojun Wei, Shen Xu, Yugang Liu, Xiguang Zhang, Cory J Xian
Osteoporosis is a systemic bone metabolic disease that is highly prevalent in the elderly population, particularly in postmenopausal women, which results in enhanced bone fragility and an increased susceptibility to fractures. However, the underlying molecular pathogenesis mechanisms still remain to be further elucidated. In this study, in a rat ovariectomy- (OVX-) induced postmenopausal osteoporosis model, aberrant expression of a microRNA miR-142-5p and vascular cell adhesion molecule 1 (VCAM-1) was found by RNA sequencing analysis and qRT-PCR...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29789689/postmenopausal-osteoporosis-is-associated-with-elevated-aldosterone-renin-ratio
#11
Xiaoyu Shu, Mei Mei, Linqiang Ma, Zhihong Wang, Shumin Yang, Jinbo Hu, Ying Song, Wenwen He, Ting Luo, Qingfeng Cheng, Yue Wang, Qianna Zhen, Qifu Li
Plasma aldosterone/renin ratio (ARR) is a useful method for primary aldosteronism (PA) screening. However some confounders, such as medications and dietary, affect plasma renin and aldosterone levels, resulting in false-negative or -positive plasma ARR. This study investigated the association between postmenopausal osteoporosis (PMO) and plasma ARR. Bone mineral density (BMD) was measured by dual-energy X-ray-absorptiometry (DXA) in 324 normotensive postmenopausal women. Based on clinical characteristics and BMD, 186 and 96 subjects were diagnosed as PMO and osteopenia respectively, and the remaining 42 subjects were grouped as normal BMD...
May 22, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29789485/association-of-plasma-lipids-and-polar-metabolites-with-low-bone-mineral-density-in-singaporean-chinese-menopausal-women-a-pilot-study
#12
Diana Cabrera, Marlena Kruger, Frances M Wolber, Nicole C Roy, John J Totman, Christiani Jeyakumar Henry, David Cameron-Smith, Karl Fraser
The diagnosis of osteoporosis is mainly based on clinical examination and bone mineral density assessments. The present pilot study compares the plasma lipid and polar metabolite profiles in blood plasma of 95 Singaporean-Chinese (SC) menopausal women with normal and low bone mineral density (BMD) using an untargeted metabolomic approach. The primary finding of this study was the association between lipids and femoral neck BMD in SC menopausal women. Twelve lipids were identified to be associated with low BMD by the orthogonal partial least squares (OPLS) model...
May 22, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29789280/factors-affecting-bone-mineral-density-among-snowy-region-residents-in-japan-analysis-using-multiple-linear-regression-and-bayesian-network-model
#13
Teppei Suzuki, Tomoko Shimoda, Noriko Takahashi, Kaori Tsutsumi, Mina Samukawa, Sadako Yoshimura, Katsuhiko Ogasawara
BACKGROUND: As the onset of osteoporosis leads to reduced activities of daily living and may result in patients being bedridden, efforts to prevent decreased bone density are necessary. Various studies on the relationship between sex, age, nutrients, and exercise habits and bone mineral density have been conducted to date. However, for snowy region residents, the magnitude of influence of various factors affecting bone mineral density and the influence level have not been clarified. OBJECTIVE: This study aimed to clarify the degree of influence and factors influencing bone mineral density based on survey results on health conditions and lifestyle habits in heavy snow areas...
May 22, 2018: Interactive Journal of Medical Research
https://www.readbyqxmd.com/read/29789006/outcomes-of-lung-transplantation-in-adults-with-bronchiectasis
#14
Jodie Birch, Syba S Sunny, Katy L M Hester, Gareth Parry, F Kate Gould, John H Dark, Stephen C Clark, Gerard Meachery, James Lordan, Andrew J Fisher, Paul A Corris, Anthony De Soyza
BACKGROUND: Lung transplantation is a well-established treatment for end-stage non-cystic fibrosis bronchiectasis (BR), though information regarding outcomes of transplantation remains limited. Our results of lung transplantation for Br are reported here. METHODS: A retrospective review of case notes and transplantation databases was conducted for patients that had underwent lung transplantation for bronchiectasis at the Freeman Hospital between 1990 and 2013. RESULTS: Fourty two BR patients underwent lung transplantation, the majority (39) having bilateral sequential lung transplantation...
May 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29789004/a-population-based-study-of-the-risk-of-osteoporosis-and-fracture-with-dutasteride-and-finasteride
#15
Tony Antoniou, Erin M Macdonald, Zhan Yao, Tara Gomes, Mina Tadrous, Joanne M-W Ho, Muhammad M Mamdani, David N Juurlink
BACKGROUND: Dutasteride is a potent inhibitor of 5-alpha reductase enzymes that reduces concentrations of dihydrotestosterone to a greater extent than finasteride. Whether this has adverse implications for bone health is unknown. We compared the risk of osteoporosis and fractures in older men treated with dutasteride or finasteride. METHODS: We conducted a population-based retrospective cohort study with high-dimensional propensity score matching of Ontario men aged 66 years or older who started treatment with dutasteride or finasteride between January 1, 2006 and December 31, 2012...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29787998/repeated-superovulation-increases-the-risk-of-osteoporosis-and-cardiovascular-diseases-by-accelerating-ovarian-aging-in-mice
#16
Jinjin Zhang, Zhiwen Lai, Liangyan Shi, Yong Tian, Aiyue Luo, Zheyuan Xu, Xiangyi Ma, Shixuan Wang
Superovulation procedures and assisted reproductive technologies have been widely used to treat couples who have infertility problems. Although generally safe, the superovulation procedures are associated with a series of complications, such as ovarian hyper-stimulation syndrome, thromboembolism, and adnexal torsion. The role of long-term repeated superovulation in ovarian aging and especially in associated disorders such as osteoporosis and cardiovascular diseases is still unclear. In this study, we sought to determine if repeated superovulation by ten cycles of treatment with pregnant mare serum gonadotropin/human chorionic gonadotropin could affect ovarian reserve, ovarian function, bone density and heart function...
May 22, 2018: Aging
https://www.readbyqxmd.com/read/29787987/modulation-of-autophagy-as-new-approach-in-mesenchymal-stem-cell-based-therapy
#17
REVIEW
Jelena Jakovljevic, C Randall Harrell, Crissy Fellabaum, Aleksandar Arsenijevic, Nemanja Jovicic, Vladislav Volarevic
Due to their trophic and immunoregulatory characteristics mesenchymal stem cells (MSCs) have tremendous potential for use in a variety of clinical applications. Challenges in MSCs' clinical applications include low survival of transplanted cells and low grafting efficiency requiring use of a high number of MSCs to achieve therapeutic benefits. Accordingly, new approaches are urgently needed in order to overcome these limitations. Recent evidence indicates that modulation of autophagy in MSCs prior to their transplantation enhances survival and viability of engrafted MSCs and promotes their pro-angiogenic and immunomodulatory characteristics...
May 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29787813/vascular-involvement-in-axial-spondyloarthropathies
#18
Clément Prati, Céline Demougeot, Xavier Guillot, Maxime Sondag, Frank Verhoeven, Daniel Wendling
Ankylosing spondylitis (AS) is a chronic inflammatory joint disease that involves the entheses, causing inflammatory pain and functional impairments. Patients may experience extraarticular manifestations such as uveitis, psoriasis, and inflammatory bowel disease. These, together with the increased risk of cardiovascular disease and osteoporosis and the development of spinal fusion, are the main determinants of adverse disease outcomes. As with many systemic inflammatory diseases, AS is associated with excess cardiovascular mortality due to increased risks of myocardial infarction, stroke, and venous thromboembolism...
May 19, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29787615/plasma-gelsolin-is-associated-with-hip-bmd-in-chinese-postmenopausal-women
#19
Wen-Yu Wang, Bing Ge, Ju Shi, Xu Zhou, Long-Fei Wu, Chang-Hua Tang, Dong-Cheng Zhu, Hong Zhu, Xing-Bo Mo, Yong-Hong Zhang, Fei-Yan Deng, Shu-Feng Lei
Gelsolin (GSN) protein, expressed in circulating monocytes, was previously reported to be associated with osteoporosis in both Chinese and Caucasian women. This study aims to test if plasma GSN protein level is associated with hip bone mineral density (BMD) in Chinese population. Based on two study Groups containing 6,308 old Chinese, we adopted extreme sampling scheme and selected 3 independent samples (Subgroups 1-3) for discovery, replication, and validation purposes. We tested plasma GSN concentration, and analyzed whether plasma GSN level differs between subjects with extremely low vs...
2018: PloS One
https://www.readbyqxmd.com/read/29787268/bisphosphonate-generated-atp-analogs-inhibit-cell-signaling-pathways
#20
Satish R Malwal, Bing O'Dowd, Xinxin Feng, Petri A Turhanen, Christopher J Shin, Jiaqi Yao, Boo Kyung Kim, Noman Baig, Tianhui Zhou, Sandhya Bansal, Rahul L Khade, Yong Zhang, Eric Oldfield
Bisphosphonates are a major class of drugs used to treat osteoporosis, Paget's disease, and cancer. They have been pro-posed to act by inhibiting one more targets including protein prenylation; the epidermal growth factor receptor; or the adenine nucleotide translocase. Inhibition of the latter is due to formation in cells of analogs of ATP: the isopentenyl ester of ATP (ApppI) or an AppXp-type analog of ATP, such as AMP-clodronate (AppCCl2p). We screened both ApppI as well as AppCCl2p against a panel of 369 kinases finding potent inhibition of some tyrosine kinases by AppCCl2p, attributable to formation of a strong hydrogen bond between tyrosine and the terminal phosphonate...
May 22, 2018: Journal of the American Chemical Society
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