keyword
MENU ▼
Read by QxMD icon Read
search

osteoporosys

keyword
https://www.readbyqxmd.com/read/28346569/vitamin-d-supplementation-in-nursing-home-residents-randomized-single-cholecalciferol-loading-protocol-vs-individualized-loading-dose-regimen
#1
C Delomas, M Hertzog, T Vogel, P O Lang
OBJECTIVE: To assess the efficacy and safety of a single cholecalciferol loading protocol in nursing home (NH) residents taking no VitD supplementation at regular basis. DESIGN: Randomized single-blind controlled study. SETTING: One NH. PARTICIPANTS: All residents. INTERVENTION: From March 21st to May 19th, 2015, NH residents were randomly assigned to either 4x100'000IU to be taken every 2 weeks (treatment group) or an individualized regimen according to baseline 25(OH)VitD level (control group)...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28346014/intestinal-absorption-and-renal-reabsorption-of-calcium-throughout-postnatal-development
#2
Megan R Beggs, R Todd Alexander
Calcium is vital for many physiological functions including bone mineralization. Postnatal deposition of calcium into bone is greatest in infancy and continues through childhood and adolescence until peek mineral density is reached in early adulthood. Thereafter, bone mineral density remains static until it eventually declines in later life. A positive calcium balance, i.e. more calcium absorbed than excreted, is crucial to bone deposition during growth and thus to peek bone mineral density. Dietary calcium is absorbed from the intestine into the blood...
April 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28345842/bone-mineral-density-in-survivors-of-childhood-acute-lymphoblastic-leukemia
#3
Farzaneh Rohani, Khadijeh Arjmandi Rafsanjani, Gholamreza Bahoush, Mansoureh Sabzehparvar, Mohammad Ahmadi
Background: The objective of this study was to evaluate bone mineral density (BMD) after completion of treatment for childhood acute lymphoblastic leukemia (ALL). Methods: In this cross-sectional study, 103 survivors of ALL aged 13.5 ± 0.45 who completed their treatment at least one year earlier were enrolled. Among these, 49.5% and 51.5% received chemotherapy alone and chemotherapy plus cranial radiotherapy, respectively. Bone mineral content, BMD, and bone mineral apparent density in the lumbar spine (LS), femoral neck (FN) and forearm were assessed using dual-energy X-ray absorptiometry (DEXA)...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28345441/prevalence-and-cost-of-subsequent-fractures-among-u-s-patients-with-an-incident-fracture
#4
Jessica Weaver, Shiva Sajjan, E Michael Lewiecki, Steven T Harris, Panagiotis Marvos
BACKGROUND: The prevalence and cost of subsequent fractures among patients with an incident fracture are not well defined. OBJECTIVE: To assess the prevalence of, and costs associated with, subsequent fractures in the year after an incident fracture. METHODS: This was a retrospective claims database analysis using data from Humana Medicare Advantage claims (Medicare group) and Optum Insight Clinformatics Data Mart commercial claims (commercial group)...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28344004/identification-of-three-early-phases-of-cell-fate-determination-during-osteogenic-and-adipogenic-differentiation-by-transcription-factor-dynamics
#5
Jeroen van de Peppel, Tanja Strini, Julia Tilburg, Hans Westerhoff, Andre J van Wijnen, Johannes P van Leeuwen
Age-related skeletal degeneration in patients with osteoporosis is characterized by decreased bone mass and occurs concomitant with an increase in bone marrow adipocytes. Using microarray expression profiling with high temporal resolution, we identified gene regulatory events in early stages of osteogenic and adipogenic lineage commitment of human mesenchymal stromal cells (hMSCs). Data analysis revealed three distinct phases when cells adopt a committed expression phenotype: initiation of differentiation (0-3 hr, phase I), lineage acquisition (6-24 hr, phase II), and early lineage progression (48-96 hr, phase III)...
March 16, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28342139/exploring-the-link-between-posttraumatic-stress-disorder-and-inflammation-related-medical-conditions-an-epidemiological-examination
#6
Jack Tsai, Jianxun Shen
There have been few epidemiological studies exploring the link between PTSD and inflammation using population-based samples. This study examined the relation between posttraumatic stress disorder (PTSD) and inflammation-related medical conditions using data from the 2013-2014 New York City Health and Nutrition Examination Survey. Using a representative sample of 1,527 residents in New York City, the association between PTSD and 17 inflammation-related medical conditions were examined. Bivariate and multivariable analyses were conducted, adjusting for demographic characteristics and lifetime depression...
March 25, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28341898/functional-block-of-il-17-cytokine-promotes-bone-healing-by-augmenting-foxo1-and-atf4-activity-in-cortical-bone-defect-model
#7
M Dixit, K B Singh, R Prakash, D Singh
We determine the effect of interleukin (IL)-17 neutralizing antibody on new bone regeneration. Anti-IL-17 antibody promoted new bone regeneration in cortical bone defect model by augmenting FOXO1 and ATF4 activity thereby decreasing oxidative stress. Our study demonstrates the bone healing and regeneration potential of neutralizing IL-17antibody in osteoporotic fractures. INTRODUCTION: The immune system plays important role in the fracture healing process. However, fracture healing is prolonged in disorders associated with systemic inflammation...
March 24, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28340962/the-reliability-of-measuring-the-density-of-the-l1-vertebral-body-on-ct-imaging-as-a-predictor-of-bone-mineral-density
#8
E-L Gerety, M A Hopper, P W P Bearcroft
AIM: To determine whether the density of the L1 vertebra measured on computed tomography (CT) images correlates with the bone mineral density (BMD) as measured by quantitative computed tomography (QCT), and to determine the reliability of L1 density measurements by different observers to see if this measure could help identify patients who would benefit from formal BMD assessment. MATERIALS AND METHODS: Non-contrast CT along with a phantom for determination of BMD was performed on 30 healthy patients...
February 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28340823/evaluation-of-bone-disease-in-kidney-transplant-recipients
#9
G Alis, M Alis, T Erturk, A H Karayagiz, I Berber, U Cakir
BACKGROUND: Kidney transplant recipients are known to have bone disease, specifically osteoporosis. In this descriptive clinical study we aimed to evaluate the incidence of osteoporosis and to determine the risk factors among our transplant recipients. METHODS: A total of 109 patients (82 males and 27 females) aged from 19 to 70 years, who had undergone kidney transplantation 12 to 69 months previously, were included in the study. Bone mineral densitometry was performed using dual-energy X-ray absorptiometry...
April 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28339869/alcohol-induces-cellular-senescence-and-impairs-osteogenic-potential-in-bone-marrow-derived-mesenchymal-stem-cells
#10
Xi Chen, Mao Li, Jinku Yan, Tao Liu, Guoqing Pan, Huilin Yang, Ming Pei, Fan He
Aims: Chronic and excessive alcohol consumption is a high-risk factor for osteoporosis. Bone marrow-derived mesenchymal stem cells (BM-MSCs) play an important role in bone formation; however, they are vulnerable to ethanol (EtOH). The purpose of this research was to investigate whether EtOH could induce premature senescence in BM-MSCs and subsequently impair their osteogenic potential. Methods: Human BM-MSCs were exposed to EtOH ranging from 10 to 250 mM. Senescence-associated β-galactosidase (SA-β-gal) activity, cell cycle distribution, cell proliferation and reactive oxygen species (ROS) were evaluated...
February 25, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28339664/adult-paget-s-disease-of-bone-a-review
#11
Stephen Paul Tuck, Robert Layfield, Julie Walker, Babitha Mekkayil, Roger Francis
Adult PD of bone is the second commonest metabolic bone condition after osteoporosis. The condition is characterized by increased bone cell activity, with bone-resorbing osteoclasts often larger and containing more nuclei than normal, and osteoblasts producing increased amounts of disorganized bone. This leads to expanded bone of poor quality possessing both sclerotic and lytic areas. PD of bone has a strong genetic element, with a family history being noted in 10-20% of cases. A number of genetic defects have been found to be associated with the condition...
February 17, 2017: Rheumatology
https://www.readbyqxmd.com/read/28339498/enhancement-of-osteogenic-differentiation-of-rat-adipose-tissue-derived-mesenchymal-stem-cells-by-zinc-sulphate-under-electromagnetic-field-via-the-pka-erk1-2-and-wnt-%C3%AE-catenin-signaling-pathways
#12
Ezzatollah Fathi, Raheleh Farahzadi
Zinc ion as an essential trace element and electromagnetic fields (EMFs) has been reported to be involved in the regulation of bone metabolism. The aim of this study was to elucidate the effects of zinc sulphate (ZnSO4) on the osteogenic differentiation of adipose tissue-derived mesenchymal stem cells (ADSCs) in the presence of EMF as a strategy in osteoporosis therapy. Alkaline phophatase (ALP) activity measurement, calcium assay and expression of several osteoblastic marker genes were examined to assess the effect of ZnSO4 on the osteogenic differentiation of ADSCs under EMF...
2017: PloS One
https://www.readbyqxmd.com/read/28339088/sclerostin-is-a-possible-candidate-marker-of-arterial-stiffness-results-from-a-cohort-study-in-catania
#13
Agostino Gaudio, Valerio Fiore, Rosario Rapisarda, Maria Helga Sidoti, Anastasia Xourafa, Antonino Catalano, Giovanni Tringali, Luca Zanoli, Salvatore Santo Signorelli, Carmelo Erio Fiore
Osteoporosis and cardiovascular disease are worldwide public health issues. Recent evidence indicates a possible role of the canonical Wnt/β-catenin signalling pathway as a common mediator between these two diseases. The aim of the present study was to investigate the relationship between serum concentrations of sclerostin and Dkk1, two extracellular inhibitors of Wnt/β-catenin signalling, with carotid intima-media thickness (CIMT) and with arterial stiffness, evaluated by measuring the pulse wave velocity (PWV) in an ambulatory population of adults...
March 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28338888/vibration-transmission-of-the-spine-during-walking-is-different-between-the-lumbar-and-thoracic-regions-in-older-adults
#14
Dafne Zuleima Morgado Ramirez, Siobhan Strike, Raymond Lee
Background: fractures occur more commonly in the thoracic than in the lumbar spine. Physical activity complemented with pharmacological interventions has been advocated as a preventive measure for osteoporosis. However, walking has been shown to produce only a small improvement in spinal bone mineral density. The characteristics of vibration transmission during walking at the lumbar and thoracic spines may be different, and this may help explain the relative incidence of fractures in the two spine regions...
March 18, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28338579/correlative-analysis-of-vertebral-trabecular-bone-microarchitecture-and-mechanical-properties-a-combined-ultra-high-field-7-tesla-mri-and-biomechanical-investigation
#15
Daphne Guenoun, Alexandre Fouré, Martine Pithioux, Sandrine Guis, Thomas Le Corroller, Jean-Pierre Mattei, Vanessa Pauly, Maxime Guye, Monique Bernard, Patrick Chabrand, Pierre Champsaur, David Bendahan
STUDY DESIGN: High resolution imaging and biomechanical investigation of ex-vivo vertebrae OBJECTIVE.: To assess bone microarchitecture of cadaveric vertebrae using ultra-high field (UHF) 7 Tesla magnetic resonance imaging (MRI) and to determine whether the corresponding microarchitecture parameters were related to BMD and bone strength assessed by dual energy X-ray absorptiometry (DXA) and mechanical compression tests. SUMMARY OF BACKGROUND DATA: Limitations of DXA for the assessment of bone fragility and osteoporosis have been recognized and criteria of microarchitecture alteration have been included in the definition of osteoporosis...
March 23, 2017: Spine
https://www.readbyqxmd.com/read/28338449/development-of-a-preoperative-predictive-model-for-major-complications-following-adult-spinal-deformity-surgery
#16
Justin K Scheer, Justin S Smith, Frank Schwab, Virginie Lafage, Christopher I Shaffrey, Shay Bess, Alan H Daniels, Robert A Hart, Themistocles S Protopsaltis, Gregory M Mundis, Daniel M Sciubba, Tamir Ailon, Douglas C Burton, Eric Klineberg, Christopher P Ames
OBJECTIVE The operative management of patients with adult spinal deformity (ASD) has a high complication rate and it remains unknown whether baseline patient characteristics and surgical variables can predict early complications (intraoperative and perioperative [within 6 weeks]). The development of an accurate preoperative predictive model can aid in patient counseling, shared decision making, and improved surgical planning. The purpose of this study was to develop a model based on baseline demographic, radiographic, and surgical factors that can predict if patients will sustain an intraoperative or perioperative major complication...
March 24, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28338064/acceleration-of-bone-regeneration-by-activating-wnt-%C3%AE-catenin-signalling-pathway-via-lithium-released-from-lithium-chloride-calcium-phosphate-cement-in-osteoporosis
#17
Li Li, Xiaozhong Peng, Yongbao Qin, Renchong Wang, Jingli Tang, Xu Cui, Ting Wang, Wenlong Liu, Haobo Pan, Bing Li
By virtue of its excellent bioactivity and osteoconductivity, calcium phosphate cement (CPC) has been applied extensively in bone engineering. Doping a trace element into CPC can change physical characteristics and enhance osteogenesis. The trace element lithium has been demonstrated to stimulate the proliferation and differentiation of osteoblasts. We investigated the fracture-healing effect of osteoporotic defects with lithium-doped calcium phosphate cement (Li/CPC) and the underlying mechanism. Li/CPC bodies immersed in simulated body fluid converted gradually to hydroxyapatite...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337901/cardiopathy-and-osteoporosis-the-epidemiology-in-a-region-of-italy
#18
A Notarnicola, G Maccagnano, L Moretti, S Tafuri, B Moretti
Cardiopathies and osteoporosis are inter-related due to pathogenetic, hormonal, genetic features as well as an increased risk of fragility. An important feature is attributed to the process of atherosclerosis, which is responsible for an osteopenia effect and degeneration of vascular walls. To date the study populations have been limited. To verify the incidence of cardio-vascular disease in a larger osteoporotic population, we designed a retrospective clinical study analyzing the “Hospital Discharge Data” (HDD) in Apulia between 2006 and 2010...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28337879/effects-of-human-parathyroid-hormone-on-bone-morphogenetic-protein-signal-pathway-following-spinal-fusion-in-diabetic-rats
#19
S Q Wu, S Z Ma, C Zhang, D Q Li, C Z Gao
Osteoporosis is a major complication in patients with diabetes mellitus. Thus, it is crucial to study the signal mechanisms responsible for enhancement of bone mass in diabetes. Administration of human parathyroid hormone (hPTH) has been reported to prevent osteoblast apoptosis and have anabolic effects on bone in animals and humans. In the present study, we examined the effects of hPTH on expression of bone morphogenetic protein type 2 (BMP-2) and its receptor BMPR2 in diabetic rats following spinal fusion...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28337806/the-pharmacological-profile-of-a-novel-highly-potent-bisphosphonate-ox14-1-fluoro-2-imidazo-1-2-%C3%AE-pyridin-3-yl-ethyl-bisphosphonate
#20
M A Lawson, F H Ebetino, A Mazur, A D Chantry, J Paton-Hough, H R Evans, D Lath, M K Tsoumpra, M W Lundy, R L M Dobson, M Quijano, A A Kwaasi, J E Dunford, X Duan, J T Triffitt, G Jeans, R G G Russell
Bisphosphonates are widely used in the treatment of clinical disorders characterized by increased bone resorption, including osteoporosis, Paget's disease and the skeletal complications of malignancy. The anti-resorptive potency of the nitrogen-containing bisphosphonates on bone in vivo is now recognised to depend upon two key properties, namely mineral binding affinity and inhibitory activity on farnesyl pyrophosphate synthase (FPPS), and these properties vary independently of each other in individual bisphosphonates...
March 24, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
keyword
keyword
76312
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"