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https://www.readbyqxmd.com/read/28651365/cathepsin-k-inhibitors-for-osteoporosis-biology-potential-clinical-utility-and-lessons-learned
#1
Matthew T Drake, Bart L Clarke, Merry Jo Oursler, Sundeep Khosla
Cathepsin K is a cysteine protease member of the cathepsin lysosomal protease family. While cathepsin K is highly expressed in osteoclasts, lower levels of cathepsin K are also found in a variety of other tissues. Secretion of cathepsin K from the osteoclast into the sealed osteoclast-bone cell interface results in efficient degradation of type I collagen. The absence of cathepsin K activity in humans results in pycnodysostosis, characterized by increased bone mineral density and fractures. Pharmacological cathepsin K inhibition leads to continuous increases in BMD for up to five years of treatment and improves bone strength at the spine and hip...
June 23, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/28650892/the-2017-hormone-therapy-position-statement-of-the-north-american-menopause-society
#2
(no author information available yet)
The 2017 Hormone Therapy Position Statement of The North American Menopause Society (NAMS) updates the 2012 Hormone Therapy Position Statement of The North American Menopause Society and identifies future research needs. An Advisory Panel of clinicians and researchers expert in the field of women's health and menopause was recruited by NAMS to review the 2012 Position Statement, evaluate new literature, assess the evidence, and reach consensus on recommendations, using the level of evidence to identify the strength of recommendations and the quality of the evidence...
June 22, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28650869/the-2017-hormone-therapy-position-statement-of-the-north-american-menopause-society
#3
(no author information available yet)
The 2017 Hormone Therapy Position Statement of The North American Menopause Society (NAMS) updates the 2012 Hormone Therapy Position Statement of The North American Menopause Society and identifies future research needs. An Advisory Panel of clinicians and researchers expert in the field of women's health and menopause was recruited by NAMS to review the 2012 Position Statement, evaluate new literature, assess the evidence, and reach consensus on recommendations, using the level of evidence to identify the strength of recommendations and the quality of the evidence...
July 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28650253/diagnosis-and-treatment-of-osteoporosis-before-and-after-fracture-a-side-by-side-analysis-of-commercially-insured-and-medicare-advantage-osteoporosis-patients
#4
Jessica Weaver, Shiva Sajjan, E Michael Lewiecki, Steven T Harris
BACKGROUND: Although treatment for osteoporosis is recommended by U.S. clinical guidelines, a lack of diagnosis and treatment is common among patients with osteoporotic fractures. OBJECTIVE: To determine the rates of osteoporosis diagnosis and treatment before and after various types of fractures. METHODS: This was a retrospective claims analysis using data from the Humana Medicare Advantage claims (Medicare group) and Optum Insight Clinformatics Data Mart commercial claims (Commercial group)...
July 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28650214/distinct-dna-methylation-profiles-in-bone-and-blood-of-osteoporotic-and-healthy-postmenopausal-women
#5
Sjur Reppe, Tonje G Lien, Yi-Hsiang Hsu, Vigdis T Gautvik, Ole K Olstad, Rona Yu, Hege G Bakke, Robert Lyle, Marianne K Kringen, Ingrid K Glad, Kaare M Gautvik
DNA methylation affects expression of associated genes and may contribute to the missing genetic effects from genome-wide association studies of osteoporosis. To improve insight into the mechanisms of postmenopausal osteoporosis, we combined transcript profiling with DNA methylation analyses in bone. RNA and DNA were isolated from 84 bone biopsies of postmenopausal donors varying markedly in bone mineral density (BMD). In all, 2529 CpGs in the top 100 genes most significantly associated with BMD were analyzed...
June 26, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28649630/towards-human-exploration-of-space-the-theseus-review-series-on-muscle-and-bone-research-priorities
#6
Thomas Lang, Jack J W A Van Loon, Susan Bloomfield, Laurence Vico, Angele Chopard, Joern Rittweger, Antonios Kyparos, Dieter Blottner, Ilkka Vuori, Rupert Gerzer, Peter R Cavanagh
Without effective countermeasures, the musculoskeletal system is altered by the microgravity environment of long-duration spaceflight, resulting in atrophy of bone and muscle tissue, as well as in deficits in the function of cartilage, tendons, and vertebral disks. While inflight countermeasures implemented on the International Space Station have evidenced reduction of bone and muscle loss on low-Earth orbit missions of several months in length, important knowledge gaps must be addressed in order to develop effective strategies for managing human musculoskeletal health on exploration class missions well beyond Earth orbit...
2017: NPJ Microgravity
https://www.readbyqxmd.com/read/28649371/recent-advances-in-microbial-fermentation-for-dairy-and-health
#7
REVIEW
Daragh Hill, Ivan Sugrue, Elke Arendt, Colin Hill, Catherine Stanton, R Paul Ross
Microbial fermentation has been used historically for the preservation of foods, the health benefits of which have since come to light. Early dairy fermentations depended on the spontaneous activity of the indigenous microbiota of the milk. Modern fermentations rely on defined starter cultures with desirable characteristics to ensure consistency and commercial viability. The selection of defined starters depends on specific phenotypes that benefit the product by guaranteeing shelf life and ensuring safety, texture, and flavour...
2017: F1000Research
https://www.readbyqxmd.com/read/28649107/-aging-and-homeostasis-management-of-disorders-in-bone-and-calcium-metabolism-associated-with-ageing
#8
Yasuhiro Takeuchi
Disorders in bone and calcium metabolism associated with aging are based on secondary hyperparathyroidism due to impaired intestinal calcium absorption caused by insufficient vitamin D actions and augmented bone resorption due to sex hormone deficiency. Both of them are involved in the development of osteoporosis that increases risk of fractures. Therefore, the most important thing for management of disorders in bone and calcium metabolism associated with aging is to prevent fractures with appropriate drugs for osteoporosis...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28649100/-aging-and-homeostasis-sex-hormones-and-aging
#9
Keizo Ohnaka
The decline in sex hormones along with aging is suggested to be involved in age-associated diseases such as cardiovascular diseases, osteoporosis, and dementia. The decrease of estrogen level after menopause is related to osteoporosis in addition to climacteric disturbance in women, while that of testosterone to sarcopenia, osteoporosis and late-onset hypogonadism in men. New treatment strategy is expected for targeting age-associated diseases against the decreased level of sex hormones.
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28649096/-aging-and-homeostasis-aging-of-bone
#10
Seijiro Mori
Quantitative as well as qualitative bone loss occurs with aging in both men and women, leading to alterations in skeletal microarchitecture and increased fracture incidence. Sex steroids, primarily estrogen and testosterone, have been shown to play a central role in the aging process of bone. The relationship between diminishing estrogen levels in women caused by ovarian failure and the development of postmenopausal osteoporosis is widely recognized. Unexpectedly, bone mineral density at various skeletal sites in men is also better correlated with circulating levels of bioavailable estrogen than with testosterone...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28648836/cortical-and-trabecular-bone-analysis-of-patients-with-high-bone-mass-from-the-barcelona-osteoporosis-cohort-using-3-dimensional-dual-energy-x-ray-absorptiometry-a-case-control-study
#11
Guillermina Orduna, Ludovic Humbert, Roger Fonolla, Jordi Romera, M Lourdes Cos, Aboro Rial, Xavier Nogués, Adolfo Diez-Perez, Leonardo Mellibovsky
High bone mass (HBM), a rare phenotype, can be detected by dual-energy X-ray absorptiometry (DXA) scanning. Measurements with peripheral quantitative computed tomography at the tibia have found increased trabecular bone mineral density and changes in cortical bone density and structure, all of which lead to increased bone strength. However, no studies on cortical and trabecular bone have been performed at the femur. The recently developed 3-dimensional (3D)-DXA software algorithm quantifies the trabecular and cortical volumetric bone mineral density (vBMD) and the anatomical distribution of cortical thickness using routine hip DXA scans...
June 22, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28647885/osteomacs-and-bone-regeneration
#12
REVIEW
Lena Batoon, Susan Marie Millard, Liza Jane Raggatt, Allison Robyn Pettit
PURPOSE OF REVIEW: Mounting evidence supporting the critical contribution of macrophages, in particular osteal macrophages, to bone regeneration is reviewed. We specifically examine the potential role of macrophages in the basic multicellular units coordinating lifelong bone regeneration via remodelling and bone regeneration in response to injury. We review and discuss the distinctions between macrophage and osteoclast contributions to bone homeostasis, particularly the dichotomous role of the colony-stimulating factor 1-colony-stimulating factor 1 receptor axis...
June 24, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28647804/estimating-the-long-term-functional-burden-of-osteoporosis-related-fractures
#13
S Fischer, K A Kapinos, A Mulcahy, L Pinto, O Hayden, R Barron
Although fractures are associated with short-term reductions in functional status, there is limited information on longer-term burden of fracture. This study documents evidence of an association between fractures and significant declines and functional health and activities that persist but attenuate beyond two years. INTRODUCTION: Although fractures are associated with short-term reductions in functional status and may have other short-term effects on healthcare utilization (hospitalization and follow-up care), there is limited information on long-term burden of fracture beyond 12 to 24 months post-fracture...
June 24, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28647803/chronic-joint-pain-and-handgrip-strength-correlates-with-osteoporosis-in-mid-life-women-a-singaporean-cohort
#14
S Logan, W P P Thu, W K Lay, L Y Wang, J A Cauley, E L Yong
This study aimed to identify novel correlates which may relate to low bone mass at lumbar spine in mid-life Asian women. The possibility of developing a prediction model for osteoporosis (OP) was explored which resulted in a risk assessment tool that performed better than currently available tools. INTRODUCTION: In order to identify novel correlates associated with low spinal bone mineral density (BMD) in mid-life women, we examined a large number of lifestyle and medical and performance measurements and developed a prediction model for triage to BMD scanning...
June 24, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28647775/a-natural-calcium-rich-marine-multi-mineral-complex-preserves-bone-structure-composition-and-strength-in-an-ovariectomised-rat-model-of-osteoporosis
#15
Orlaith Brennan, Joseph Sweeney, Brian O'Meara, Amro Widaa, Franck Bonnier, Hugh J Byrne, Denise M O'Gorman, Fergal J O'Brien
Calcium supplements are used as an aid in the prevention of osteopenia and osteoporosis and also for the treatment of patients when used along with medication. Many of these supplements are calcium carbonate based. This study compared a calcium-rich, marine multi-mineral complex (Aquamin) to calcium carbonate in an ovariectomised rat model of osteoporosis in order to assess Aquamin's efficacy in preventing the onset of bone loss. Animals were randomly assigned to either non-ovariectomy control (Control), ovariectomy (OVX) plus calcium carbonate, ovariectomy plus Aquamin or ovariectomy plus Aquamin delay where Aquamin treatment started 8 weeks post OVX...
June 24, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28647365/conjugated-linoleic-acid-prevents-age-induced-bone-loss-in-mice-by-regulating-both-osteoblastogenesis-and-adipogenesis
#16
Guanlin Lin, Huan Wang, Jun Dai, Xiao Li, Ming Guan, Shutao Gao, Qing Ding, Huaixi Wang, Huang Fang
Osteoporosis (OP) can increase the risk of bone fracture and other complications, which is a major clinical problem. Previous researches have revealed that conjugated linoleic acid (CLA) can promote the bone formation. But the mechanisms are not clear. Thus, we tested the hypothesis that CLA acts on bone formation might be via mTOR Complex1 (mTORC 1) pathway by in vitro and vivo assays. We studied the effect of CLA mix on MC3T3-E1 pre-osteoblasts differentiation into osteoblasts, and bone formation under osteoporotic conditions...
June 21, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28646995/executive-summary-of-the-2017-kdigo-chronic-kidney%C3%A2-disease-mineral-and-bone-disorder-ckd-mbd-guideline-update-what-s-changed-and-why-it-matters
#17
Markus Ketteler, Geoffrey A Block, Pieter Evenepoel, Masafumi Fukagawa, Charles A Herzog, Linda McCann, Sharon M Moe, Rukshana Shroff, Marcello A Tonelli, Nigel D Toussaint, Marc G Vervloet, Mary B Leonard
The KDIGO 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of CKD-MBD represents a selective update of the prior CKD-MBD Guideline published in 2009. This update, along with the 2009 publication, is intended to assist the practitioner caring for adults and children with chronic kidney disease (CKD), those on chronic dialysis therapy, or individuals with a kidney transplant. This review highlights key aspects of the 2017 CKD-MBD Guideline Update, with an emphasis on the rationale for the changes made to the original guideline document...
July 2017: Kidney International
https://www.readbyqxmd.com/read/28646831/assessment-of-differences-in-nutrients-consumption-in-women-diagnosed-with-osteoporosis-as-compared-to-a-healthy-control-group
#18
Agata Wawrzyniak, Patrycja Klimczyk, Agnieszka Woźniak, Anna Anyżewska, Magdalena Leonkiewicz
Background: Osteoporosis is a condition that has been much more frequent for women, which is related to menopause and to their lower bone mineral density (BMD). Inappropriate diet is among the development factors of the disease. Objective: To assess differences in consumption of particular nutrients among women with and without osteoporosis diagnosed. Material and Methods: The study was conducted in 2013 in a group of 100 women aged 51-70, using a questionnaire, including a 24-hour recall related to a participant’s nutrients consumptions...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28646489/functional-analysis-of-p-ala253_leu254insasn-mutation-in-pls3-responsible-for-x-linked-osteoporosis
#19
Lianqing Wang, Qiaoli Zhai, Peiqing Zhao, Xinxin Xiang, Xiaowei Zhang, Wenxiu Tian, Tao Li
Mutations in Plastin-3 (PLS3) have been identified as a cause of X-linked osteoporosis. To reveal the molecular mechanism of PLS3 on osteoporosis, we characterized the p.Ala253_Leu254insAsn mutation in PLS3. We first identified Lymphocyte cytosolic protein 1 (LCP1) as a binding partner of PLS3 and the mutation disrupted the interaction between them. We then confirmed the roles of PLS3 and LCP1 in the regulation of intracellular Ca(2+) , which was weakened by the mutant PLS3. Moreover, the interaction between PLS3 and LCP1 was enhanced under a low concentration of extracellular Ca(2+) ...
June 24, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28646476/the-relationship-between-circulating-adiponectin-leptin-and-vaspin-with-bone-mineral-density-bmd-arterial-calcification-and-stiffness-a-cross-sectional-study-in-post-menopausal-women
#20
N Tanna, K Patel, A E Moore, D Dulnoan, S Edwards, G Hampson
OBJECTIVE: To explore the relationship between circulating adiponectin, leptin and vaspin with bone mineral density (BMD), arterial stiffness and vascular calcification in post-menopausal women. We hypothesised that adipokines produced by adipose tissue may be mediators of bone and cardiovascular disease (CVD) and explain, in part, the observed association between osteoporosis and CVD. DESIGN: We studied 386 ambulant community dwelling postmenopausal women aged (mean [SD] 61 [6...
June 23, 2017: Journal of Endocrinological Investigation
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