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https://www.readbyqxmd.com/read/28221297/optimal-epinephrine-concentration-and-time-delay-to-minimize-perfusion-in-eyelid-surgery-measured-by-laser-based-methods-and-a-novel-form-of-extended-wavelength-diffuse-reflectance-spectroscopy
#1
Rafi Sheikh, Ulf Dahlstrand, Khashayar Memarzadeh, Jonas Blohmé, Nina Reistad, Malin Malmsjö
OBJECTIVE: This study investigates the hypoperfusion effects of epinephrine in local anesthesia in eyelid surgery. A novel form of extended-wavelength diffuse reflectance spectroscopy was evaluated. METHODS: Blood perfusion in porcine eyelid flaps was measured using laser Doppler velocimetry and laser speckle contrast imaging, whereas the tissue response was measured using diffuse reflectance spectroscopy with a broad spectrum (450-1550 nm). Epinephrine was either injected cumulatively, 0...
February 17, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28217677/delayed-hemorrhage-effect-of-local-anesthesia-with-epinephrine-in-the-loop-electrosurgical-excisional-procedure
#2
Yong Jae Lee, Yunjin Park, In Ok Lee, Jung Won Yoon, Jung Yoon Lee, Sang Wun Kim, Sunghoon Kim, Young Tae Kim, Eun Ji Nam
OBJECTIVE: The aim of this study was to investigate factors preventing delayed hemorrhage after the loop electrosurgical excisional procedure (LEEP). METHODS: Medical records of patients who underwent LEEP at one university affiliated hospital from October 2013 to January 2015 were reviewed. Patients with or without delayed hemorrhage were classified. LEEP was performed either in an operating room under general anesthesia or in a procedure room with local anesthesia in the outpatient clinic...
January 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28217067/septo-optic-dysplasia-de-morsier-s-syndrome
#3
Pedro Reis, Joana Mourão
Septo-optic dysplasia (SOD)/de Morsier's syndrome is characterized by optic nerve hypoplasia, pituitary endocrine dysfunction, and midline brain abnormalities. Hypopituitarism, hypothyroidism, hypogonadism, and adrenal insufficiency can lead to severe hypoglycemia, adrenal crisis, seizures, and sudden death. Anesthetic management of SOD was associated with high perioperative mortality. A 9-year-old male child proposed for dental treatments/extractions. Medical history of SOD with hypopituitarism, hypothyroidism, and delayed psychomotor development was observed...
January 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28215909/eslicarbazepine-acetate-for-neuropathic-pain-headache-and-cranial-neuralgia-evidence-and-experience
#4
A Alcántara Montero, C I Sánchez Carnerero
INTRODUCTION: Eslicarbazepine acetate (ESL), together with carbamazepine and oxcarbazepine, belongs to the dibenzazepine family. According to the latest clinical practice guidelines, tricyclic antidepressants, dual antidepressants (venlafaxine, duloxetine), and some antiepileptics (gabapentin, pregabalin) are first-line drugs for neuropathic pain; tramadol, lidocaine 5% patches, and capsaicin 8% patches are considered second-line drugs; and strong opioids constitute a third line of treatment...
February 16, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28215749/steady-state-centrifugal-input-via-the-lateral-olfactory-tract-modulates-spontaneous-activity-in-the-rat-main-olfactory-bulb
#5
Neil C Ford, Edwin R Griff
Mitral and tufted cells in the main olfactory bulb (MOB) of anesthetized rats exhibit vigorous spontaneous activity, action potentials produced in the absence of odor stimuli. The central hypothesis of this paper is that tonic activity of centrifugal input to the MOB modulates the spontaneous activity of MOB neurons. The spontaneous activity of centrifugal fibers causes a baseline of steady-state neurotransmitter release, and odor stimulation produces transient changes in the resulting spontaneous activity...
February 16, 2017: Neuroscience
https://www.readbyqxmd.com/read/28215443/2-mepivacaine-seems-to-do-better-than-2-%C3%A2-lidocaine-in-achieving-successful-anesthesia-in-posterior-teeth-with-irreversible-pulpitis
#6
Romina Brignardello-Petersen
No abstract text is available yet for this article.
February 16, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28215043/is-the-change-of-percutaneous-oxygen-pressure-available-to-judge-the-effects-of-brachial-plexus-block
#7
Tomoki Nishiyama
BACKGROUND: To know the objective methods of the effects of the brachial plexus block, we studied the changes in percutaneous oxygen pressure (tcPO₂) with the hypothesis that tcPO₂ increases significantly on the blocked arm in comparison with the non-blocked arm, a phenomenon which is connected with vasodilation following the brachial plexus block. METHODS: Fifteen patients scheduled for upper extremity surgery, aged 20 to 70 years, with ASA physical status I or II were included...
February 19, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/28213242/cocaine-profiling-implementation-of-a-predictive-model-by-atr-ftir-coupled-with-chemometrics-in-forensic-chemistry
#8
Stefano Materazzi, Adolfo Gregori, Luigi Ripani, Azzurra Apriceno, Roberta Risoluti
In this study, a strategy based on Infrared Spectroscopy with Fourier Transformed and Attenuated Total Reflectance associated with chemometrics (ATR-FTIR) is proposed to identify the chemical "fingerprint" of cocaine samples. To this end, standard mixtures of cocaine and cuttings at differents ratio were investigated in order to develop a multivariate classification model to simultaneously predict the composition of the samples and to obtain a profile of adulteration of cocaine seizures. In addition, the application of a Partial Least Squares (PLS) and Principal Component Regression (PCR) calibration approaches were found to be a useful tool to predict the content of cocaine, caffeine, procaine, lidocaine and phenacetin in drug seizures...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28212905/will-patients-perceive-a-numbing-spray-to-be-an-effective-method-of-anesthetizing-an-intravenous-site
#9
Pamela G Falotico, Linda Ryan
PURPOSE: The purpose of this study was to determine if patients would perceive a numbing spray to be an effective method of anesthetizing an intravenous (IV) site. DESIGN: A quasi-experimental design was used. METHODS: The first 50 patients were given no pain management strategy before their IV insertion, and the next 50 patients were given a numbing spray. FINDINGS: The hypothesis that pain scores reported from the numbing spray group would be less than pain scores reported from the non-numbing spray group was not supported...
February 2017: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/28211640/complexation-of-oxethazaine-with-2-hydroxypropyl-%C3%AE-cyclodextrin-increased-drug-solubility-decreased-cytotoxicity-and-analgesia-at-inflamed-tissues
#10
Andressa R Prado, Fabiano Yokaichiya, Margareth Kazuyo Kobayashi Dias Franco, Camila Morais Gonçalves da Silva, Laura Oliveira-Nascimento, Michelle Franz-Montan, Maria C Volpato, Luís F Cabeça, Eneida de Paula
OBJECTIVES: Oxethazaine (OXZ) is one of the few local anaesthetics that provides analgesia at low pH, but presents poor solubility, cytotoxicity and no parenteral formulations. To address these issues, we aimed to prepare OXZ host-guest inclusion complex with hydroxypropyl-beta-cyclodextrin (HP-β-CD). METHODS: The inclusion complex was formed by co-solubilization, followed by a job plot analysis to determine stoichiometry of complexation and dialysis equilibrium analysis (based on UV/VIS absorption and fluorescence profiles of OXZ)...
February 17, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28210848/prefrontal-hippocampal-coupling-by-theta-rhythm-and-by-2-5%C3%A2-hz-oscillation-in-the-delta-band-the-role-of-the-nucleus-reuniens-of-the-thalamus
#11
Alexis Roy, Frans Pettersson Svensson, Amna Mazeh, Bernat Kocsis
Rhythmic synchronizations of hippocampus (HC) and prefrontal cortex (PFC) at theta frequencies (4-8 Hz) are thought to mediate key cognitive functions, and disruptions of HC-PFC coupling were implicated in psychiatric diseases. Theta coupling is thought to represent a HC-to-PFC drive transmitted via the well-described unidirectional HC projection to PFC. In comparison, communication in the PFC-to-HC direction is less understood, partly because no known direct anatomical connection exists. Two recent findings, i...
February 16, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28210379/two-crosslinking-technologies-for-superficial-reticular-dermis-injection-a-comparative-ultrasound-and-histologic-study
#12
Patrick Micheels, Stéphanie Besse, Didier Sarazin
Background: Few hyaluronic acid fillers have been developed for superficial injection. Objective: To compare the diffusion and integration properties of cohesive polydensified matrix and Vycross® technology hyaluronic acid fillers with lidocaine following injection into the superficial reticular dermis. Methods and materials: Two subjects received two injections each of cohesive polydensified matrix and Vycross® hyaluronic acid (0.2mL/site) in the superficial reticular dermis of the buttock under ultrasound control...
January 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28209507/ultrasound-guided-pulsed-radiofrequency-stimulation-of-posterior-tibial-nerve-a-potential-novel-intervention-for-recalcitrant-plantar-fasciitis
#13
Yung-Tsan Wu, Chih-Ya Chang, Yu-Ching Chou, Chun-Chang Yeh, Tsung-Ying Li, Heng-Yi Chu, Liang-Cheng Chen
OBJECTIVE: To evaluate the therapeutic benefit of ultrasound-guided pulsed radiofrequency (PRF) stimulation at the posterior tibial nerve (PTN) in patients with recalcitrant plantar fasciitis (PF). DESIGN: A prospective, randomized, double-blinded, placebo-controlled trial (12-week follow-up). SETTING: Outpatient of local medical center settings. PARTICIPANTS: Thirty-six patients with recalcitrant PF were randomized and 36 participants were included in the final data analysis...
February 13, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28205117/a-randomized-comparison-between-costoclavicular-and-paracoracoid-ultrasound-guided-infraclavicular-block-for-upper-limb-surgery
#14
Prangmalee Leurcharusmee, Maria Francisca Elgueta, Worakamol Tiyaprasertkul, Thitipan Sotthisopha, Artid Samerchua, Aida Gordon, Julian Aliste, Roderick J Finlayson, De Q H Tran
BACKGROUND: This two-centre randomized trial compared costoclavicular and paracoracoid ultrasound-guided infraclavicular brachial plexus block in patients undergoing upper limb surgery. We hypothesized that both techniques would result in similar onset times and designed the study as an equivalence trial. METHODS: Ninety patients undergoing upper limb surgery at or distal to the elbow were randomly allocated to receive a costoclavicular (n = 45) or paracoracoid (n = 45) ultrasound-guided infraclavicular brachial plexus block...
February 15, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28202186/stimulation-of-rat-cranial-dura-mater-with-potassium-chloride-causes-cgrp-release-into-the-cerebrospinal-fluid-and-increases-medullary-blood-flow
#15
Mária Dux, Christine Will, Mirjam Eberhardt, Michael J M Fischer, Karl Messlinger
Primary headaches may be accompanied by increased intracranial blood flow induced by the release of the potent vasodilator calcitonin gene-related peptide (CGRP) from activated meningeal afferents. We aimed to record meningeal and medullary blood flow simultaneously and to localize the sites of CGRP release in rodent preparations in vivo and ex vivo. Blood flow in the exposed rat parietal dura mater and the medulla oblongata was recorded by laser Doppler flowmetry, while the dura was stimulated by topical application of 60mM potassium chloride (KCl)...
February 10, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28196085/what-device-would-be-best-for-early-infant-male-circumcision-in-east-and-southern-africa-provider-experiences-and-opinions-with-three-different-devices-in-kenya
#16
Robert C Bailey, Irene Nyaboke, Fredrick O Otieno
Voluntary medical male circumcision (VMMC) reduces risk of HIV acquisition in heterosexual men by approximately 60%. As some countries approach targets for proportions of adolescents and adults circumcised, some are considering early infant male circumcision (EIMC) as a means to achieve sustainability of VMMC for long term reduction of HIV incidence. Evaluations of specialized devices for EIMC are important to provide programs with information required to make informed decisions about how to design safe, effective EIMC programs...
2017: PloS One
https://www.readbyqxmd.com/read/28195483/development-of-oromucosal-dosage-forms-by-combining-electrospinning-and-inkjet-printing
#17
Mirja Palo, Karin Kogermann, Ivo Laidmäe, Andres Meos, Maren Preis, Jyrki Heinämäki, Niklas Sandler
Printing technology has been shown to enable flexible fabrication of solid dosage forms for personalized drug therapy. Several methods can be applied for tailoring the properties of the printed pharmaceuticals. In this study, the use of electrospun fibrous substrates in the fabrication of inkjet-printed dosage forms was investigated. A single-drug formulation with lidocaine hydrochloride (LH) and a combination drug system containing LH and piroxicam (PRX) for oromucosal administration were prepared. The LH was deposited on the electrospun and cross-linked gelatin substrates by inkjet printing, whereas PRX was incorporated within the substrate fibers during electrospinning...
February 14, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28194608/rage-deficiency-attenuates-the-protective-effect-of-lidocaine-against-sepsis-induced-acute-lung-injury
#18
Zhuo Zhang, Jie Zhou, Changli Liao, Xiaobing Li, Minghua Liu, Daqiang Song, Xian Jiang
Lidocaine (Lido) is reported to suppress inflammatory responses and exhibit a therapeutic effect in models of cecal ligation and puncture (CLP)-induced acute lung injury (ALI). The receptor for advanced glycation end product (RAGE) exerts pro-inflammatory effects by enhancing pro-inflammatory cytokine production. However, the precise mechanism by which Lido confers protection against ALI is not clear. ALI was induced in RAGE WT and RAGE knockout (KO) rats using cecal ligation and puncture (CLP) operations for 24 h...
February 13, 2017: Inflammation
https://www.readbyqxmd.com/read/28193364/application-of-carbon-nanosorbent-for-prime-pass-through-cleanup-of-10-selected-local-anesthetic-drugs-in-human-plasma-samples
#19
Jian-Bo Ma, Li-Ming Zhao, Qiu-Hong Rui, Yu-Feng Liao, Yan-Min Chen, Jin Xu, Yan Zhu, Yong-Gang Zhao
A novel PRiME (process, robustness, improvements, matrix effects, ease of use) pass-through cleanup procedure has been developed to improve the existing commercially available designs. Carbon nanosorbents, i.e., magnetic modified carboxyl-graphene (Mag-CG) and magnetic modified carboxyl-carbon nanotubes (Mag-CCNTs), have been synthesised and evaluated in PRiME pass-through cleanup procedure for human plasma prior to analysis of 10 selected local anesthetic drugs by liquid chromatography-tandem quadrupole mass spectrometry (LC-MS/MS)...
April 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28191793/lateral-decubitus-position-vs-lithotomy-position-which-is-the-best-way-to-minimize-patient-s-pain-perception-during-transrectal-prostate-biopsy
#20
Phil Hyun Song, Young Hwii Ko
INTRODUCTION: Considering the distinctive nature in terms of psychological stress and anal tone of position which is generally selected between lithotomy and left lateral decubitus (LLD), we postulated its effect on pain perception during biopsy, and investigated their association. MATERIALS AND METHODS: A prospective study for comparison of two biopsy positions which were perform in a different working day was conducted for 208 men (lithotomy position=86, LLD=122)...
January 27, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
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