keyword
https://read.qxmd.com/read/38462787/pudendal-nerve-blockade-for-persistent-genital-arousal-disorder-pgad-a-clinical-review-and-case-report
#1
Michael J Gyorfi, Alaa Abd-Elsayed
BACKGROUND: Persistent genital arousal disorder (PGAD) is a condition characterized by unwanted and potentially painful genital sensations or spontaneous orgasms without stimulation. We present a case of a 55-year-old woman with refractory genital arousal disorder that was treated with serial pudendal nerve blocks. CASE: RW is a 55-year-old woman with chronic pelvic pain, pudendal neuralgia, MDD, SI, GAD, CRPS, and persistent genital arousal disorder for 11 years...
March 10, 2024: Pain Practice: the Official Journal of World Institute of Pain
https://read.qxmd.com/read/38205449/effectiveness-of-brexpiprazole-in-a-patient-with-bipolar-disorder-and-comorbid-persistent-genital-arousal-disorder-genito-pelvic-dysesthesia-a-case-report
#2
Yuki Hirose, Yasunori Oda, Tatsuya Kobayashi, Kazuki Okada, Masaomi Iyo
Although the symptoms of persistent genital arousal disorder/genito-pelvic dysesthesia (PGAD/GPD) can have negative impacts on patients' lives, it is an under-recognized clinical entity. We describe the case of a 61-year-old Japanese female who suffered simultaneously from bipolar disorder and PGAD/GPD. She developed PGAD/GPD approx. 10 years after being diagnosed with bipolar disorder. Despite 20 years of various drug treatments, her bipolar disorder and PGAD/GPD symptoms showed little improvement. She had also undergone multiple sessions of cognitive behavioral therapy (CBT) and mindfulness, nerve block, botulinum toxin injections, and laser treatment for PGAD/GPD...
December 2023: Curēus
https://read.qxmd.com/read/38175364/real-world-effectiveness-of-dupilumab-in-adult-and-adolescent-patients-with-atopic-dermatitis-2-year-interim-data-from-the-prose-registry
#3
JOURNAL ARTICLE
Eric L Simpson, Ben Lockshin, Lara Wine Lee, Zhen Chen, Moataz Daoud, Andrew Korotzer
INTRODUCTION: There is a scarcity of data beyond 1 year for the use of dupilumab to treat atopic dermatitis (AD) in a real-world setting. This study aimed to evaluate the 2-year effectiveness of dupilumab among adult and pediatric patients with moderate-to-severe AD included in a real-world, longitudinal database study. METHODS: PROSE is an ongoing, prospective, observational, multi-center registry in the USA and Canada, designed to collect real-world data from patients aged ≥ 12 years with moderate-to-severe AD who initiate dupilumab in accordance with country-specific prescribing information...
January 4, 2024: Dermatology and Therapy
https://read.qxmd.com/read/38129493/clinical-characterisation-of-women-with-persistent-genital-arousal-disorder-the-ipgad-study
#4
JOURNAL ARTICLE
Franziska M L M Kümpers, Christopher Sinke, Cordula Schippert, Katja Kollewe, Sonja Körner, Peter Raab, Bernhard Meyer, Sabine Maschke, Matthias Karst, Christian Sperling, Eleni Dalkeranidis, Tillmann H C Krüger
Persistent Genital Arousal Disorder (PGAD) is a rare condition-mostly in women-where patients perceive prolonged genital arousal without any sexual desire or stimulation. Etiopathological considerations reach from peripheral to central issues over local disturbance of the pudendal nerve to neuropathy, psychosocial, and pharmacological theories. Since well controlled clinical studies about PGAD in conjunction with a mental and somatic health status are missing, this study is a detailed clinical investigation of PGAD patients compared to healthy controls...
December 20, 2023: Scientific Reports
https://read.qxmd.com/read/37925660/tofacitinib-efficacy-in-patients-with-rheumatoid-arthritis-and-probable-depression-anxiety-post-hoc-analysis-of-phase-3-and-3b-4-randomized-controlled-trials
#5
JOURNAL ARTICLE
Gustavo Citera, Rakesh Jain, Fedra Irazoque, Hugo Madariaga, David Gruben, Lisy Wang, Lori Stockert, Karina Santana, Abbas Ebrahim, Dario Ponce de Leon
INTRODUCTION: The aim of our work is to assess the prevalence of probable major depressive disorder and/or probable generalized anxiety disorder (pMDD/pGAD) in patients with moderate to severe rheumatoid arthritis (RA), and to evaluate the efficacy of tofacitinib on RA symptoms stratified by baseline pMDD/pGAD status. METHODS: Data were pooled from five phase 3 randomized controlled trials (RCTs) and one phase 3b/4 RCT, assessing tofacitinib 5 or 10 mg twice daily (BID), adalimumab (two RCTs), or placebo...
November 5, 2023: Rheumatology and Therapy
https://read.qxmd.com/read/37878759/interpersonal-experiences-with-persistent-genital-arousal-connections-between-symptom-disclosure-partner-responses-and-catastrophizing-on-relationship-adjustment-and-symptom-severity
#6
JOURNAL ARTICLE
Kayla M Mooney, Maeve Mulroy, Évéline Poirier, Caroline F Pukall
Increased research attention to interpersonal factors in genitopelvic pain conditions, such as vulvodynia, have led to more comprehensive understanding of couple dynamics in pain, sexual, and relationship outcomes. There has been very little examination of interpersonal factors in Persistent Genital Arousal Disorder/Genitopelvic Dysesthesia (PGAD/GPD), a distressing condition involving persistent sensations of arousal and often pain. The aims of the present study were to examine whether individuals disclose their symptoms to intimate partners and whether interpersonal variables (e...
October 25, 2023: Journal of Sex & Marital Therapy
https://read.qxmd.com/read/37691471/assessment-of-colour-modifications-in-two-different-composite-resins-induced-by-the-influence-of-chlorhexidine-mouthwashes-and-gels-with-and-without-anti-staining-properties-an-in-vitro-study
#7
JOURNAL ARTICLE
V Checchi, E Forabosco, F Dall'Olio, S Kaleci, L Giannetti, L Generali
OBJECTIVES: Chlorhexidine (CHX)-based products are the most effective chemical agents used in plaque control and oral disinfection. One of their side effects is tooth and restoration staining. For this reason, CHX products with anti-discolouration systems (ADS) have been developed. The aim of this in vitro study was to compare different CHX-based products (gel and mouthwash) with or without ADS in composite colour modification. METHODS: Two hundred specimens were created, 100 of which were made of packable composite and 100 of flowable composite...
September 11, 2023: International Journal of Dental Hygiene
https://read.qxmd.com/read/37598985/predictors-of-psychosocial-and-functional-outcomes-in-persistent-genital-arousal-disorder-genito-pelvic-dysesthesia-application-of-the-fear-avoidance-model
#8
JOURNAL ARTICLE
Robyn A Jackowich, Évéline Poirier, Caroline F Pukall
Persistent Genital Arousal Disorder/Genito-Pelvic Dysesthesia (PGAD/GPD), which affects up to 4.3% of individuals, is a distressing and poorly understood condition characterized by persistent, unwanted, and often painful sensations of genito-pelvic arousal (e.g., throbbing) in the absence of sexual desire. PGAD/GPD is associated with significant negative impacts on psychosocial wellbeing and daily functioning. Recent research has indicated that PGAD/GPD shares many similarities with other forms of chronic genito-pelvic pain...
August 18, 2023: Journal of Pain
https://read.qxmd.com/read/37253921/psychological-treatment-of-persistent-genital-arousal-disorder-genitopelvic-dysesthesia-using-an-integrative-approach
#9
JOURNAL ARTICLE
Kathleen E Merwin, Lori A Brotto
Persistent genital arousal disorder/genitopelvic dysesthesia (PGAD/GPD) is characterized by persistent, unwanted physiological genital arousal (i.e., sensitivity, fullness, and/or swelling) in the absence of sexual excitement or desire which can persist for hours to days and causes significant impairment in psychosocial well-being (e.g., distress) and daily functioning. The etiology and course of PGAD/GPD is still relatively unknown and, unsurprisingly, there are not yet clear evidence-based treatment recommendations for those suffering from PGAD/GPD...
May 30, 2023: Archives of Sexual Behavior
https://read.qxmd.com/read/37164147/exploratory-factor-analysis-of-shared-and-specific-genetic-associations-in-depression-and-anxiety
#10
JOURNAL ARTICLE
Chun'e Li, Shiqiang Cheng, Yujing Chen, Yumeng Jia, Yan Wen, Huijie Zhang, Chuyu Pan, Jingxi Zhang, Zhen Zhang, Xuena Yang, Peilin Meng, Yao Yao, Feng Zhang
BACKGROUND: Previous genetic studies of anxiety and depression were mostly based on independent phenotypes. This study aims to investigate the shared and specific genetic structure between anxiety and depression. METHOD: To identify the underlying factors of Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and their combined scale (joint scale), we employed exploratory factor analysis (EFA) using the eigenvalue of parallel analysis...
May 9, 2023: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/37098194/persistent-genital-arousal-disorder-the-present-knowledge
#11
REVIEW
Natalia Ewa Kapuśniak, Magdalena Piegza
Persistent genital arousal disorder (PGAD) is a relatively recently described sexual disorder, characterized by symptoms of spontaneous genital arousal which persist in the absence of sexual desire and may affect women and men. Epidemiological studies conducted so far indicate that the prevalence of PGAD in the population may reach 1-4%. The etiology of PGAD remains unclear and complex, hypothesized causes include vascular, neurological, hormonal, psychological, pharmacologic, dietary, mechanical factors or a combination of these factors...
December 31, 2022: Psychiatria Polska
https://read.qxmd.com/read/37057583/pudendal-neuromodulation-is-feasible-and-effective-after-pudendal-nerve-entrapment-surgery
#12
JOURNAL ARTICLE
Kristen M Meier, Patrick M Vecellio, Kim A Killinger, Judith A Boura, Kenneth M Peters
BACKGROUND: Patients with intractable pain in the pudendal nerve distribution may benefit from pudendal neuromodulation; however, some may have previously undergone pudendal nerve entrapment surgery (PNES), potentially altering nerve anatomy and function. AIM: We examined pudendal neuromodulation outcomes in patients with prior PNES. METHODS: Patients with a history of PNES and quadripolar, tined pudendal lead placement for urogenital pain were reviewed...
June 1, 2022: Journal of Sexual Medicine
https://read.qxmd.com/read/37057574/treatments-for-persistent-genital-arousal-disorder-in-women-a-scoping-review
#13
REVIEW
María Martín-Vivar, Alejandro Villena-Moya, Gemma Mestre-Bach, Felipe Hurtado-Murillo, Carlos Chiclana-Actis
BACKGROUND: Persistent genital arousal disorder (PGAD) is characterized by elevated discomfort associated with persistent genital arousal in the absence of sexual desire. AIM: To perform a scoping review of the proposed treatments for PGAD and their efficacy. METHODS: A scoping review was carried out (PRISMA-Scr) that included articles on PGAD as the main disorder, only in women, which explained, in detail, the treatment and its efficacy, was empirical, was written in English and Spanish...
June 1, 2022: Journal of Sexual Medicine
https://read.qxmd.com/read/37051963/orgasm-and-related-disorders-depend-on-neural-inhibition-combined-with-neural-excitation
#14
REVIEW
Barry R Komisaruk, Maria Cruz Rodriguez Del Cerro
INTRODUCTION: Prevalent models of sexual desire, arousal and orgasm postulate that they result from an excitatory process, whereas disorders of sexual desire, arousal and orgasm result from an inhibitory process based on psychosocial, pharmacological, medical, and other factors. But neuronal excitation and active neuronal inhibition normally interact at variable intensities, concurrently and continuously. We propose herein that in conjunction with neuronal excitation, neuronal inhibition enables the generation of the intense, non-aversive pleasure of orgasm...
October 1, 2022: Sexual Medicine Reviews
https://read.qxmd.com/read/36874234/persistent-genital-arousal-disorder-two-case-studies-and-exploration-of-a-novel-treatment-modality
#15
Meghan Scantlebury, Romeo Lucas
Persistent genital arousal disorder (PGAD) is characterized by persistent unwanted feelings of sexual arousal that can be debilitating. Despite first being defined >20 years ago, the precise etiology and treatment of this disorder remain elusive. Mechanical disruption of nerves, neurotransmitter changes, and cyst formation have all been considered as etiologies involved with the development of PGAD. With limited and ineffective treatment modalities, many women live with their symptoms untreated or undertreated...
2023: Women's health reports
https://read.qxmd.com/read/36826430/examining-the-psychometric-properties-of-the-hbi-19-scale-in-a-sample-of-women-with-persistent-genital-arousal-symptoms
#16
JOURNAL ARTICLE
M E Mulroy, R A Jackowich, C F Pukall
Persistent Genital Arousal Disorder/Genito-Pelvic Dysesthesia (PGAD/GPD) is a highly distressing, yet poorly understood health concern characterized by persistent, unwanted, and unpleasant genital arousal sensations in the absence of psychological arousal and desire. PGAD/GPD symptoms can be reduced by engaging in frequent sexual behaviors, meaning that hypersexual behavior may be present as a feature of PGAD/GPD in some cases. Given this association and the current lack of measures designed for assessment of PGAD/GPD specifically, the present study aimed to investigate the psychometric properties of the Hypersexual Behavior Inventory (HBI-19) in a sample of women with PGAD/GPD symptoms...
February 24, 2023: Journal of Sex Research
https://read.qxmd.com/read/36796791/evaluation-of-loop-mediated-isothermal-amplification-assay-for-visual-detection-of-acinetobacter-baumannii-directly-from-soil-and-water-sample-from-mangalore
#17
JOURNAL ARTICLE
Srajana Nayak, Nia Do Carmo Lobo, Karanth Padyana Anupama, Ashwath Nayak, Sadanand Dangari Akshay, Biswajit Maiti
Acinetobacter baumannii is a well-known nosocomial pathogen that commonly inhabits soil and water and has been implicated in numerous hospital-acquired infections. The existing methods for detecting A. baumannii have several drawbacks, such as being time-consuming, expensive, labor-intensive, and unable to distinguish between closely related Acinetobacter species. Thus, it is important to have a simple, rapid, sensitive, and specific method for its detection. In this study, we developed a loop-mediated isothermal amplification (LAMP) assay using hydroxynaphthol blue dye to visualize A...
February 16, 2023: Letters in Applied Microbiology
https://read.qxmd.com/read/36763933/lumbar-endoscopic-spine-surgery-for-persistent-genital-arousal-disorder-genitopelvic-dysesthesia-resulting-from-lumbosacral-annular-tear-induced-sacral-radiculopathy
#18
JOURNAL ARTICLE
Choll W Kim, Irwin Goldstein, Barry R Komisaruk, Sue W Goldstein, Noel N Kim, Rose Hartzell-Cushanick, Maria Uloko, Alyssa Yee
BACKGROUND: Persistent genital arousal disorder/genitopelvic dysesthesia (PGAD/GPD) is characterized by distressing, abnormal genitopelvic sensations, especially unwanted arousal. In a subgroup of patients with PGAD/GPD, cauda equina Tarlov cyst-induced sacral radiculopathy has been reported to trigger the disorder. In our evaluation of lumbosacral magnetic resonance images in patients with PGAD/GPD and suspected sacral radiculopathy, some had no Tarlov cysts but showed lumbosacral disc annular tear pathology...
February 14, 2023: Journal of Sexual Medicine
https://read.qxmd.com/read/36621910/experiences-from-daily-practice-of-upadacitinib-treatment-on-atopic-dermatitis-with-a-focus-on-hand-eczema-results-from-the-bioday-registry
#19
JOURNAL ARTICLE
E Kamphuis, L Loman, H L Han, G L E Romeijn, K Politiek, M L A Schuttelaar
BACKGROUND: Real-world data on the effectiveness of upadacitinib on atopic dermatitis (AD), hand eczema (HE) and HE in the context of AD are limited. OBJECTIVES: To evaluate the effectiveness and safety of upadacitinib on AD and on HE in patients with AD. METHODS: This prospective observational cohort study includes clinical outcomes: Eczema Area and Severity Index (EASI), Investigator's Global Assessment (IGA), Hand Eczema Severity Index (HECSI), Photographic guide; and PROMs: average pruritus and pain Numeric Rating Scale (NRS) score of the past week, Patient-Oriented Eczema Measure (POEM), Patient-Oriented Eczema, Dermatology Life Quality Index (DLQI), Atopic Dermatitis Control Tool (ADCT), Patient Global Assessment of Disease (PGAD), Quality Of Life Hand Eczema Questionnaire (QOLHEQ) at baseline, week 4, and week 16 of upadacitinib-treated patients...
January 9, 2023: Contact Dermatitis
https://read.qxmd.com/read/36357896/exploring-the-link-between-eating-disorders-and-persistent-genital-arousal-disorder-genito-pelvic-dysesthesia-first-description-and-a-systematic-review-of-the-literature
#20
REVIEW
Hartmut Imgart, Annika Zanko, Sandra Lorek, Patti-Sue Schlichterle, Michael Zeiler
BACKGROUND: Persistent Genital Arousal Disorder/Genito-Pelvic Dysesthesia (PGAD/GPD) characterized by recurrent physiological genital without corresponding psychological arousal is a poorly understood and researched condition. Based on the first two case descriptions of eating disorders directly linked to PGAD/GPD the aim of this paper was to systematically review the literature on possible associations between eating disorders and PGAD/GPD. METHOD: A systematic literature search on eating disorders and PGAD/GPD was conducted in PubMed, PsycINFO, and Scopus, complemented by Google Scholar...
November 10, 2022: Journal of Eating Disorders
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