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Dong Joon Kim, Mee-Hyun Lee, KangDong Liu, Do Young Lim, Eunmiri Roh, Hanyong Chen, Sung-Hyun Kim, Jung-Hyun Shim, Myoung Ok Kim, Wenwen Li, Fayang Ma, Mangaladoss Fredimoses, Ann M Bode, Zigang Dong
Herbacetin is a flavonol compound that is found in plants such as flaxseed and ramose scouring rush herb, it possesses a strong antioxidant capacity, and exerts anticancer effects on colon and breast cancer. However, the effect of herbacetin on skin cancer has not been investigated. Herein, we identified herbacetin as a dual V-akt murine thymoma viral oncogene homolog (AKT) and ornithine decarboxylase (ODC) inhibitor, and illustrated its anticancer effects in vitro and in vivo against cutaneous squamous cell carcinoma (SCC) and melanoma cell growth...
September 23, 2017: Carcinogenesis
Jinfeng Liang, Yingying Yue, Haitang Jiang, Deqin Geng, Jun Wang, Jianxin Lu, Shenghua Li, Kezhong Zhang, Aiqin Wu, Yonggui Yuan
BACKGROUND: The effects of BDNF on post stroke depression (PSD) may be influenced by genetic variations in intracellular signal transduction pathways, such as the p11/tPA/BDNF pathway. In this study, we aimed to determine the association of polymorphisms in candidate genes of the gene transduction pathway with PSD, as well as the effects of the interactions between genes in our Chinese sample. METHODS: Two-hundred-fifty-four Chinese samples with acute ischaemic stroke included 122 PSD patients and 132 nonPSD patients...
September 29, 2017: Journal of Affective Disorders
A P Jadhav, H-C Diener, A Bonafe, V M Pereira, E I Levy, B W Baxter, T G Jovin, R G Nogueira, D R Yavagal, C Cognard, D D Purcell, B K Menon, R Jahan, J L Saver, M Goyal
BACKGROUND AND PURPOSE: Patient selection for endovascular therapy remains a great challenge in clinic practice. We sought to determine the effect of baseline CT and angiography on outcomes in the Solitaire With the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke (SWIFT PRIME) trial and to identify patients who would benefit from endovascular stroke therapy. MATERIALS AND METHODS: The primary end point was a 90-day modified Rankin Scale score of 0-2...
October 12, 2017: AJNR. American Journal of Neuroradiology
Amerigo Menghi, Giuseppe Mazzitelli, Emanuele Marzetti, Francesco Barberio, Emanuela D'Angelo, Giulio Maccauro
INTRODUCTION: Complex tibial plateau fractures are characterized by compression and sinking of one or both the articular surfaces. In this study, we evaluated clinical and radiological outcomes in patients with 41.C1,41.C2,41.C3 fractures according to AO classification. We also provide a specific therapeutic algorithm for each type of fracture. MATERIAL AND METHODS: The study was conducted in 43 patients who underwent surgical treatment for complex tibial plateau fractures and were followed for a minimum of 12 months...
October 2017: Injury
Soowon Kang, Kyungtaek Im, Geon Kim, Hyeyoung Min
BACKGROUND: Ginsenosides are the major components of Panax ginseng Meyer, an herbal medicine used for the treatment of various diseases. Different ginsenosides contribute to the biological properties of ginseng, such as antimicrobial, anticancer, and immunomodulatory properties. In this study, we investigated the antiviral effects of 15 ginsenosides and compound K on gammaherpesvirus. METHODS: The antiviral activity of ginsenosides was examined using the plaque-forming assay and by analyzing the expression of the lytic gene...
October 2017: Journal of Ginseng Research
Bao-Xia Dong, Hua-Bo Chen, Yi-Chen Wu, Juan Zhao, Yun-Lei Teng, Wen-Long Liu, Zong-Wei Li
Using the methodology of extension of reduced transition metal-grafted ε-Keggin polyoxoanions with two types of terphenyl-based tricarboxylates of H3L(1) (3,5',3''-position substitution) and H3L(2) (4,5',4''-position substitution) we isolated two (3,6)-connected 3D polyoxometalate-based metal-organic frameworks, [TBA]3[H3PMo12O40][Zn4L(2)] (1, YZU-105), and [TPA]3[H3PMo12O40][Zn4L(1)]·0.5H2O (2, YZU-106) (H3L(1) = [1,1';3',1''-terphenyl]-3,5',3''-tricarboxylic acid; H3L(2) = [1,1';3',1''-terphenyl]-4,5',4''-tricarboxylic acid; TBA = tetrabutylammonium; TPA = tetrapropylammonium)...
October 11, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Chloé Michel, Corey N Miller, Rita Küchler, Benedikt Brors, Mark S Anderson, Bruno Kyewski, Sheena Pinto
The basic two-step terminal differentiation model of the medullary thymic epithelial cell (mTEC) lineage from immature MHC class II (MHCII)(lo) to mature MHCII(hi) mTECs has recently been extended to include a third stage, namely the post-Aire MHCII(lo) subset as identified by lineage-tracing models. However, a suitable surface marker distinguishing the phenotypically overlapping pre- from the post-Aire MHCII(lo) stage has been lacking. In this study, we introduce the lectin Tetragonolobus purpureas agglutinin (TPA) as a novel cell surface marker that allows for such delineation...
October 9, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
Lin Wang, Rui Zhang, Xue You, Huanhuan Zhang, Siying Wei, Tingting Cheng, Qianqian Cao, Zhenzhen Wang, Yan Chen
CDK4 is crucial for G1-to-S transition of cell cycle. It is well established that ubiquitin-mediated degradations of CDK inhibitors and cyclins are pivotal for the timely and unidirectional progression of cell cycle. However, how CDK4 itself is modulated by ubiquitin-mediated degradation has been elusive. Here we report that the steady-state level of CDK4 is controlled by PAQR4, a member of the progestin and adipoQ receptor family, and SKP2, an E3 ubiquitin ligase. Knockdown of PAQR4 leads to reduction of cell proliferation, accompanied by reduced protein level of CDK4...
September 12, 2017: Journal of Molecular Cell Biology
Jennifer E Vernia, Mary R Warmin, Jeanette A Krause, David L Tierney, Michael J Baldwin
The tripodal amine chelate with two pyridyl groups and an α-hydroxy acid (AHA) group, Pyr-TPA-AHA, was synthesized. Different Fe(III) complexes form with this chelate depending upon the counterion of the Fe(III) source used in the synthesis. A dinuclear complex, Fe(III)2(Pyr-TPA-AHA)2(μ-O), 1, and mononuclear complexes Fe(III)(Pyr-TPA-AHA)X (X = Cl(-) or Br(-), 2 and 3, respectively) were synthesized. 2 can be easily converted to 1 by addition of silver nitrate or a large excess of water. The structure of 1 was solved by X-ray crystallography (C32H34N6O7Fe2·13H2O, a = 14...
October 9, 2017: Inorganic Chemistry
Jordan A Miller, Margaret A Stanton, Elizabeth V Lonsdorf, Kaitlin R Wellens, A Catherine Markham, Carson M Murray
Examining the ontogeny of conflict-mitigating behaviours in our closest living relatives is an important component of understanding the evolutionary origins of cooperation in our species. In this study, we used 26 years of data to investigate the emergence of third-party affiliation (TPA), defined as affiliative contact given to recipients of aggression by uninvolved bystanders (regardless of initiation), in wild immature eastern chimpanzees (Pan troglodytes schweinfurthii) of Gombe National Park, Tanzania...
September 2017: Royal Society Open Science
Alessandro Lunghi, Federico Totti, Stefano Sanvito, Roberta Sessoli
We perform a systematic investigation of the spin-phonon coupling leading to spin relaxation in the prototypical mononuclear single molecule magnet [(tpa(Ph))Fe](-). In particular we analyze in detail the nature of the most relevant vibrational modes giving rise to the relaxation. Our fully ab initio calculations, where the phonon modes are evaluated at the level of density functional theory and the spin-phonon coupling by mapping post-Hartree-Fock electronic structures onto an effective spin Hamiltonian, reveal that acoustic phonons are not active in the spin-phonon relaxation process of dilute SMMs crystals...
September 1, 2017: Chemical Science
Burçin Ergene Öz, Gülçin Saltan Çitoğlu, Esra Küpeli Akkol, İpek Süntar, Özlem Bahadır Acıkara
ETHNOPHARMACOLOGICAL RELEVANCE: Dried roots of Ononis spinosa L. are traditionally used for their diuretic, anti-inflammatory and wound healing effects. AIM OF THE STUDY: Isolation of the bioactive compounds of Ononis spinosa L. subsp. leiosperma (Boiss.) Sirj. MATERIALS AND METHODS: Ethyl acetate extract prepared from the roots of Ononis spinosa L. subsp. leiosperma (Boiss.) Sirj. was subjected to silica gel column. The fractions were tested for their wound healing and anti-inflammatory activities...
October 5, 2017: Journal of Ethnopharmacology
Amrit S Khalsa, Gregory M Mundis, Mitsuru Yagi, Richard Fessler, Shay Bess, Naobumi Hosogane, Paul Park, Khoi Than, Alan Daniels, Justin Iorio, Justin Ledesma, Stacie Tran, Robert K Eastlack
STUDY DESIGN: Prospectively-collected survey study OBJECTIVE.: To determine the consistency with which spino-pelvic parameters (SPP) are determined in patients with lumbosacral transitional vertebrae (LSTV). SUMMARY OF BACKGROUND DATA: The incidence of LSTV in the general population is as high as 35.6%. The often fixed nature of LSTV relative to the pelvis, but lumbar-type appearance, may lead to differential use of the S1 endplate when performing SPP assessment...
October 3, 2017: Spine
Sarah Daisy Kosa, Chenglin Ye, Lehana Thabane, Amiram Gafni, Charmaine E Lok
INTRODUCTION: Hemodialysis catheter malfunction is problematic. We aimed to determine clinical, catheter, and hemodialysis variables that predict: (i) catheter malfunction requiring recombinant tissue-plasminogen activator (TPA) treatment and (ii) the success of TPA administration. METHODS: Clinical, catheter, and hemodialysis variables were collected from a cohort of 559 catheters (141,526 catheter days) in 175 hemodialysis patients (2008-2011). Time to, and predictors of, catheter malfunction were determined for all catheters and primary catheters only, analyzed by Cox-proportional hazard model, multi-variable logistic regression model, and mixed-effect logistic regression models...
October 4, 2017: Journal of Vascular Access
Birgit Småbrekke, Ludvig Balteskard Rinde, Erin Mathiesen Hald, Inger Njølstad, Ellisiv B Mathiesen, Stein Harald Johnsen, John-Bjarne Hansen, Sigrid K Braekkan, Willem M Lijfering
BACKGROUND: Whether a relationship between atherosclerosis and subsequent venous thromboembolism (VTE) exists is controversial. OBJECTIVE: To investigate the association between carotid atherosclerosis and VTE using repeated measurements of intima media thickness (IMT) and total plaque area (TPA) in participants recruited from the general population. METHODS: Participants were recruited from the fourth (1994-1995), fifth (2001-2002) and sixth (2007-2008) surveys of the Tromsø study...
October 5, 2017: Journal of Thrombosis and Haemostasis: JTH
Jörn F Dopheide, Tim Sebastian, Rolf P Engelberger, Axel Haine, Nils Kucher
BACKGROUND: Rheolytic thrombectomy (RT) for acute iliofemoral deep vein thrombosis (DVT) with first-generation techniques is often incomplete and adjunctive conventional catheter-directed thrombolysis (CDT) is required in more than half of patients to achieve venous patency. PATIENTS AND METHODS: From the prospective Bern Venous Stent Registry, we investigated rates of primary treatment success, primary patency, and post-thrombotic syndrome (PTS) from 40 consecutive patients (mean age 51 ± 19 years, 45 % women) with acute iliofemoral DVT, treated with a novel directional RT technology and stent placement...
October 5, 2017: VASA. Zeitschrift Für Gefässkrankheiten
Talha Butt, Anders Gottsäter, Jan Apelqvist, Gunnar Engström, Stefan Acosta
The presence of diabetes mellitus is rarely addressed in acute lower limb ischaemia (ALLI). The aim of this study was to evaluate the outcome of local intra-arterial thrombolysis for ALLI in patients with diabetes mellitus (DM). Outcome of all thrombolytic events performed in an endovascular first-strategy centre during a 13-year period between 2001 and 2013 in patients with ALLI were followed to January 2017. A propensity score adjusted analysis was performed to evaluate results in patients with (n = 83) versus without (n = 316) DM...
October 4, 2017: Journal of Thrombosis and Thrombolysis
H Jacques Garrigues, Kellie Howard, Serge Barcy, Minako Ikoma, Ashlee V Moses, Gail H Deutsch, David Wu, Keiji Ueda, Timothy M Rose
The latency-associated nuclear antigen (LANA) of the Kaposi sarcoma herpesvirus (KSHV) performs a variety of functions to establish and maintain KSHV latency. During latency, LANA localizes to discrete punctate spots in the nucleus where it tethers viral episomes to cellular chromatin and interacts with nuclear components to regulate cellular and viral gene expression. Using highly sensitive tyramide signal amplification (TSA), we determined that LANA localizes to the cytoplasm in different cell types undergoing the lytic cycle of replication after de novo primary infection and after spontaneous, TPA-, or ORF50/RTA-induced activation...
October 4, 2017: Journal of Virology
Zhongxing Wang, Weiran Shan, Jiangbei Cao, Max Wintermark, Wenqi Huang, Zhiyi Zuo
Tissue plasminogen activator (tPA) is used in fewer than 4% of patients after ischemic stroke because of its narrow therapeutic time window. We tested whether pyrrolidine dithiocarbamate (PDTC), a drug with multiple mechanisms to provide neuroprotection, can be used to extend the therapeutic time window of tPA. Three-month-old male Sprague-Dawley rats were subjected to embolic stroke in the area supplied by the right middle cerebral artery. tPA at 10 mg/kg was given intravenously 4 h after the onset of stroke...
October 4, 2017: Journal of Neuroscience Research
Junsheng Chen, Pavel Chábera, Torbjörn Pascher, Maria E Messing, Richard Schaller, Sophie Canton, Kaibo Zheng, Tõnu Pullerits
Cesium lead bromide (CsPbBr3) perovskite nanocrystals (NCs), with large two-photon absorption (TPA) cross-section and bright photoluminescence (PL), have been demonstrated as stable two-photon-pumped lasing medium. With two-photon excitation, red-shifted PL spectrum and increased PL lifetime is observed compared with one-photon excitation. We have investigated the origin of such difference using time-resolved laser spectroscopies. We ascribe the difference to the enhanced size selection of NCs by two-photon excitation...
October 5, 2017: Journal of Physical Chemistry Letters
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