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https://www.readbyqxmd.com/read/29458014/topical-delivery-of-l-theanine-ameliorates-tpa-induced-acute-skin-inflammation-via-downregulating-endothelial-pecam-1-and-neutrophil-infiltration-and-activation
#1
Wei-Jie Zeng, Zhi Tan, Xing-Fei Lai, Ya-Nan Xu, Chun-Lin Mai, Jun Zhang, Zhen-Jia Lin, Xian-Guo Liu, Shi-Li Sun, Li-Jun Zhou
l-theanine, the most abundant free amino acid in tea, has been documented to possess many different bioactive properties through oral or intragastrical delivery. However, little is known about the effect of topical delivery of l-theanine on acute inflammation. In the present study, by using 12-O-tetradecanoylphorbol-13-acetate (TPA, 2.5 μg/ear)-induced ear edema model in mice, we first found that single-dose local pretreatment of l-theanine 30 min before TPA time- and dose-dependently suppressed the increases in both skin thickness and weight...
February 16, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29457408/-double-plate-fixation-via-combined-approaches-for-the-treatment-of-old-tibial-plateau-fractures-of-schatzker-type-iv
#2
Hong-Lue Tan, Peng-Yi Dai, Wei-Feng Liu, Yan-Hao Yuan
OBJECTIVE: To explore the clinical efficacy of double-plate fixation for the treatment of old tibial plateau fractures with Schatzker type IV through anterior midline and posteromedial approaches. METHODS: From July 2013 to July 2015, 15 patients with old tibial plateau fractures were treated with internal fixation using locking reconstructive plate for the posteromedial fragment and anatomical locking plate for anteromedial fragment through antero midline and posteromedial approaches...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29455351/lead-facilitates-foci-formation-in-a-balb-c-3t3-two-step-cell-transformation-model-role-of-ape1-function
#3
Pablo Hernández-Franco, Martín Silva, Rodrigo Franco, Mahara Valverde, Emilio Rojas
Several possible mechanisms have been examined to gain an understanding on the carcinogenic properties of lead, which include among others, mitogenesis, alteration of gene expression, oxidative damage, and inhibition of DNA repair. The aim of the present study was to explore if low concentrations of lead, relevant for human exposure, interfere with Ape1 function, a base excision repair enzyme, and its role in cell transformation in Balb/c-3T3. Lead acetate 5 and 30 μM induced APE1 mRNA and upregulation of protein expression...
February 17, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29454747/plasminogen-activator-inhibitor-1-reduces-tpa-dependent-fibrinolysis-and-intrahepatic-hemorrhage-in-experimental-acetaminophen-overdose
#4
Asmita Pant, Anna K Kopeć, Kevin S Baker, Holly Cline-Fedewa, Daniel A Lawrence, James P Luyendyk
Acetaminophen (APAP)-induced liver injury in mice is associated with activation of the coagulation cascade and deposition of fibrin in liver. Plasminogen activator inhibitor-1 (PAI-1) is an important physiological inhibitor of tissue-type plasminogen activator (tPA) and plays a critical role in fibrinolysis. PAI-1 expression is increased in both experimental APAP-induced liver injury and patients with acute liver failure. Prior studies have shown that PAI-1 prevents intrahepatic hemorrhage and mortality after APAP challenge, but the downstream mechanisms are not clear...
February 15, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29450213/differential-regulation-of-pai-1-in-hantavirus-cardiopulmonary-syndrome-and-hemorrhagic-fever-with-renal-syndrome
#5
Carla Bellomo, Miša Korva, Anna Papa, Satu Mäkelä, Jukka Mustonen, Tatjana Avšič-Županc, Antti Vaheri, Valeria P Martinez, Tomas Strandin
We analyzed the levels of circulating tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI)-1 in acute hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS). The levels of tPA commonly increased in both diseases, whereas PAI-1 correlated with disease severity in HCPS but not in HFRS.
February 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29444972/usefulness-of-adamts13-to-predict-response-to-recanalization-therapies-in-acute-ischemic-stroke
#6
Alejandro Bustamante, MingMing Ning, Teresa García-Berrocoso, Anna Penalba, Cristina Boada, Alba Simats, Jorge Pagola, Marc Ribó, Carlos Molina, Eng Lo, Joan Montaner
OBJECTIVE: We aimed to analyze ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) in relation to arterial recanalization in patients treated with IV tissue plasminogen activator (tPA) and in relation to futile recanalization in patients treated with mechanical thrombectomy. METHODS: Acute ischemic stroke patients (n = 108) with documented arterial occlusions treated with IV-tPA were selected. ADAMTS13 activity was measured by ELISA in samples collected before treatment...
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29442984/cyclohexylation-of-resorcinol-with-cyclohexanol-catalyzed-by-tungstophosphoric-acid-supported-zirconia-catalysts
#7
V V Balasubramanian, B M Devassay, S B Halligudi, R Deepika, S B Umbarakar, A Vinu
We demonstrate a highly active and reusable heterogeneous catalyst system, tungstophosphoric acid (TPA) supported on zirconia (ZrO2), for the cyclohexylation of resorcinol by cyclohexanol to produce value added chemicals such as 2-cyclohexyl resorcinol, 4-cyclohexyl resorcinol and 3-Hydroxy cyclohexyl phenyl ether under liquid phase reaction condition. TPA/ZrO2 catalysts prepared with different TPA loadings (5-30 wt.%) by wet impregnation method and calcined in the temperature range of 650-850 °C were characterized by Nitrogen sorption analysis, XRD, FTIR, DTG and DTA, and 31P MAS NMR spectroscopy...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442683/time-dependent-density-functional-theory-analysis-of-triphenylamine-functionalized-graphene-doped-with-transition-metals-for-photocatalytic-hydrogen-production
#8
Elder A V Mota, Abel F G Neto, Francisco C Marques, Gunar V S Mota, Marcelo G Martins, Fabio L P Costa, Rosivaldo S Borges, Antonio M J C Neto
The electronic structures and optical properties of triphenylamine-functionalized graphene (G-TPA) doped with transition metals, using water as a solvent, were theoretically investigated to verify the efficiency of photocatalytic hydrogen production with the use of transition metals. This study was performed by Density Functional Theory and Time-dependent Density Functional Theory through Gaussian 09W software, adopting the B3LYP functional for all structures. The 6-31g(d) basis set was used for H, C and N atoms, and the LANL2DZ basis set for transition metals using the Effective Core Potentials method...
July 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29440586/national-practice-patterns-of-obtaining-informed-consent-for-stroke-thrombolysis
#9
Scott J Mendelson, D Mark Courtney, Elisa J Gordon, Leena F Thomas, Jane L Holl, Shyam Prabhakaran
BACKGROUND AND PURPOSE: No standard approach to obtaining informed consent for stroke thrombolysis with tPA (tissue-type plasminogen activator) currently exists. We aimed to assess current nationwide practice patterns of obtaining informed consent for tPA. METHODS: An online survey was developed and distributed by e-mail to clinicians involved in acute stroke care. Multivariable logistic regression analyses were performed to determine independent factors contributing to always obtaining informed consent for tPA...
February 12, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29439128/comparison-of-proteomic-quantification-approaches-for-hepatic-drug-transporters-multiplexed-global-quantitation-correlates-with-targeted-proteomic-quantitation
#10
Anna Vildhede, Chuong Nguyen, Brian K Erickson, Ryan C Kunz, Richard Jones, Emi Kimoto, Francis Bourbonais, A David Rodrigues, Manthena V Varma
Targeted protein quantification using liquid chromatography-tandem mass spectrometry with stable isotope labelled standards is recognized as the gold standard of practice for protein quantification. Such assays, however, can only cover a limited number of proteins and developing targeted methods for larger numbers of proteins require substantial investment. Alternatively, large-scale global proteomic experiments along with computational methods such as the "total protein approach" (TPA) have the potential to provide extensive protein quantification...
February 8, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29438548/descriptive-sensory-and-instrumental-texture-profile-analysis-of-woody-breast-in-marinated-chicken
#11
M E Aguirre, C M Owens, R K Miller, C Z Alvarado
The broiler industry is currently experiencing a muscle anomaly referred to as "woody breast," and the effect of different cooking methods on the marination properties of severe woody breast (SWB) has not yet been reported. This study compared the texture attributes of marinated (injected) normal (NOR) and SWB using a convection oven and a flat-top grill. The objectives were 1) to develop and validate a descriptive texture attribute panel with 6 trained panelists using a 16-point scale and 2) to evaluate the instrumental texture profile analysis (TPA) using a texture analyzer...
February 8, 2018: Poultry Science
https://www.readbyqxmd.com/read/29438080/thrombus-neutrophil-extracellular-traps-content-impair-tpa-induced-thrombolysis-in-acute-ischemic-stroke
#12
Celina Ducroux, Lucas Di Meglio, Stephane Loyau, Sandrine Delbosc, William Boisseau, Catherine Deschildre, Malek Ben Maacha, Raphael Blanc, Hocine Redjem, Gabriele Ciccio, Stanislas Smajda, Robert Fahed, Jean-Baptiste Michel, Michel Piotin, Laurence Salomon, Mikael Mazighi, Benoit Ho-Tin-Noe, Jean-Philippe Desilles
BACKGROUND AND PURPOSE: Neutrophil Extracellular Traps (NETs) are DNA extracellular networks decorated with histones and granular proteins produced by activated neutrophils. NETs have been identified as major triggers and structural factors of thrombosis. A recent study designated extracellular DNA threads from NETs as a potential therapeutic target for improving tissue-type plasminogen activator (tPA)-induced thrombolysis in acute coronary syndrome. The aim of this study was to assess the presence of NETs in thrombi retrieved during endovascular therapy in patients with acute ischemic stroke (AIS) and their impact on tPA-induced thrombolysis...
February 8, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29437224/perception-and-measurement-of-food-texture-solid-foods
#13
K Nishinari, Y Fang
There is still a gap between instrumental measurement and sensory evaluation because of the complexity of food texture in spite of many efforts. In sensory evaluation, the terms describing the texture should be well understood by panelists, which poses a problem of establishing lexicons and training panelists. In the instrumental measurement, more efforts are required to understand the large deformation and fracture behaviour of foods. The texture profile analysis (TPA) proposed by Alina Szczesniak, Malcolm Bourne and Sherman has been applied to many foods, and was useful to develop the understanding of textures...
February 13, 2018: Journal of Texture Studies
https://www.readbyqxmd.com/read/29430329/-spino-pelvic-sagittal-parameters-in-an-asymptomatic-population-in-argentina
#14
Alfredo Guiroy, Martín Gagliardi, Alfredo Sícoli, Nicolás Gonzalez Masanés, Alejandro Morales Ciancio, Pablo Jalón, Juan José Mezzadri
Objectives: To assess and describe spinal and pelvic sagittal parameters in a series of 100 Argentinian volunteers. Methods: Lateral full-spine X-rays were obtained prospectively from 100 volunteers (30 males and 70 females), average age 34.1 years. All the volunteers were asymptomatic at the time of the study. Full-length left lateral spine radiographs (36'' cassette) were made using Kodak Elite CR equipment. The authors made determinations for the digital X-rays using Surgimap®, version 2...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29429245/-effects-of-expanded-anterolateral-approach-for-tibial-plateau-fractures-involved-the-posterolateral-column
#15
Y W Zhao, J B Xie, G Z Ding
Objective: To explore the short-term effects of expanded anterolateral approach in treating fracture involved the posterolateral tibial plateau. Methods: A retrospective analysis of the clinical data from 16 patients undergoing extended anterolateral approach for fracture involved the posterolateral tibial plateau in the First Affiliated Hospital of Wannan Medical College between January 2013 and July 2016 was done. The patients were treated with 3.5 mm proximal "L" type proximal tibial locking compression plate with four locking screws through the nail row technique...
January 30, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29429001/essential-oil-from-waste-leaves-of-curcuma-longa-l-alleviates-skin-inflammation
#16
Anant Kumar, Karishma Agarwal, Monika Singh, Archana Saxena, Pankaj Yadav, Anil Kumar Maurya, Anju Yadav, Sudeep Tandon, Debabrata Chanda, Dnyaneshwar U Bawankule
BACKGROUND: Curcuma longa L. is an important industrial crop used by medicinal and cosmetic industries in the world. Its leaves are a waste material after harvesting rhizomes. The aim of the study was to evaluate the chemical and pharmacological profile of essential oil from waste leaves of Curcuma longa (EOCl) against skin inflammation. METHODS: EOCl was subjected to gas chromatography (GC) analysis for identification of essential oil constituents and its anti-inflammatory evaluation through in vitro and in vivo models...
February 10, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29428989/determination-of-oligomers-in-virgin-and-recycled-polyethylene-terephthalate-pet-samples-by-uplc-ms-qtof
#17
Sara Ubeda, Margarita Aznar, Cristina Nerín
An oligomer is a molecule that consists of a few monomer units. It can be formed during polymer manufacturing and also due to polymer degradation processes or even during use conditions. Since oligomers are not included in chemical databases, their identification is a complex process. In this work, the oligomers present in 20 different PET pellet samples have been determined. Two different sample treatment procedures, solvent extraction and total dissolution, were applied in order to select the most efficient one...
February 10, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29425674/-predictive-variables-for-failure-in-administration-of-intrapleural-tpa-dnase-in-patients-with-complicated-parapneumonic-effusions-empyema
#18
Danai Khemasuwan, Jeffrey Sorensen, David C Griffin
INTRODUCTION: Combined Intrapleural therapy with tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) has been shown to reduce the need for surgical intervention for complicated pleural effusion/empyema (CPE/empyema). For patients in whom tPA/DNase is likely to fail, however, receipt of this therapy may simply delay the inevitable. The goal of this study was to identify risk factors for failure of combined intrapleural therapy. METHODS: We performed a retrospective chart review of patients who received intrapleural tPA/DNase for the treatment of CPE/empyema...
February 6, 2018: Chest
https://www.readbyqxmd.com/read/29423390/dual-effects-of-high-protein-diet-on-mouse-skin-and-colonic-inflammation
#19
Xuelei Cui, Eunjung Kim
Chronic inflammation is a major etiology of cancer. Accumulating epidemiological and experimental evidences suggest that intake of high protein diet (HPD) is associated with colitis-associated colon cancer, however, most of the studies were confined in colon. Systemic influence of HPD on inflammation indices in different tissues of an organism has never been studied. We therefore investigated the effect of HPD on mouse skin and colonic inflammation using the well characterized inflammation induction protocol in both tissues (12- O -tetradecanoylphorbol-13-acetate [TPA] for skin and dextran sodium sulfate [DSS] for colon)...
January 2018: Clinical Nutrition Research
https://www.readbyqxmd.com/read/29422380/improvement-in-door-to-needle-time-in-patients-with-acute-ischemic-stroke-via-a-simple-stroke-activation-protocol
#20
Benjamin Y Q Tan, Nicholas J H Ngiam, Sibi Sunny, Wan Yee Kong, Howen Tam, Tiong Beng Sim, Benjamin S H Leong, Chandra Bhartendu, Prakash R Paliwal, Raymond C S Seet, Bernard P L Chan, Hock Luen Teoh, Vijay K Sharma, Leonard L L Yeo
BACKGROUND: In acute ischemic stroke (AIS), treatment with intravenous tissue-type plasminogen activator (IV-tPA) is time-sensitive. All stroke centers make continual efforts to reduce door-to-needle time (DNT) with varying success. We present the impact of modifications to our stroke activation protocol on DNT. METHODS: We included 404 consecutive patients with AIS receiving IV-tPA between January 2014 and December 2016. First changes in stroke activation protocol were made in March 2015 in the form of prenotification by paramedics, direct transfer from ambulance to computed tomography (CT) scanner, and rapid en route neurological assessment by an emergency physician and neurologist...
February 5, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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