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https://www.readbyqxmd.com/read/28091783/lifetime-based-oxygen-sensing-properties-of-palladium-ii-and-platinum-ii-meso-tetrakis-4-phenylethynyl-phenylporphyrin
#1
Emel Önal, Stephan Saß, Jeanne Hurpin, Kadriye Ertekin, Sevinc Zehra Topal, Michael U Kumke, Catherine Hirel
High oxygen permeable [poly(TMSP)] nanofibers incorporating porphyrin macrocycle as luminescence indicators were prepared by electrospinning technique. The porphyrins involves were modified by i) introducing phenylacetylide substituents on the para position of the phenyl moieties and ii) varying the metal centers [Pt(II) or Pd(II)] of the meso-tetrakisphenylporphyrins. A set of nanofibers; (Pt-TPP)NF, (Pd-TPP)NF, (Pt-TPA)NF and (Pd-TPA)NF were obtained to study their structure-activity relationship toward oxygen...
January 14, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28081351/the-effect-of-methylprednisolone-treatment-on-fibrinolysis-thecoagulation-system-and-blood-loss-in-cardiac-surgery
#2
Leila Ebrahimi, Maryam Kheirandish, Mahnoosh Foroughi
BACKGROUND/AIM: The purpose of this study was to examine steroid pretreatment in order to decrease postoperative coagulopathy disorders and bleeding. MATERIALS AND METHODS: In this randomized double-blinded study, the efficacy of low versus high doses of methylprednisolone on the coagulation system and postoperative bleeding was compared in patients who were undergoing cardiac surgery with cardiopulmonary bypass (CPB). The platelet response to agonists, D-dimer concentration, tissue plasminogen activator (tPA), plasminogen activator inhibitor (PAI-1) antigens, and platelet receptors CD42b, CD62P, and CD41a were evaluated...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28079399/safety-and-efficacy-of-tissue-plasminogen-activator-tpa-and-deoxyribonuclease-dnase-for-complicated-pleural-effusions-secondary-to-abdominal-pathology
#3
Adnan Majid, Sebastian Ochoa, Sumit Chatterji, Sebastian Fernandez-Bussy, Fayez Kheir, Estefania Rivera, George Cheng, Erik Folch
RATIONALE: Exudative pleural effusions may arise secondary to inflammation of intra-abdominal structures. Pleural space loculations can complicate these effusions, preventing adequate chest tube drainage and leading to consideration of surgical intervention. Previous studies have demonstrated that intrapleural administration of tissue plasminogen activator (tPA) combined with human recombinant deoxyribonuclease (DNase) can improve fluid drainage and reduce surgery for patients with loculated parapneumonic effusions; however, the efficacy of this treatment has not been evaluated for complicated pleural effusions attributed to intraabdominal inflammation...
January 12, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28079139/blood-occludin-level-as-a-potential-biomarker-for-early-blood-brain-barrier-damage-following-ischemic-stroke
#4
Rong Pan, Kewei Yu, Theodore Weatherwax, Handong Zheng, Wenlan Liu, Ke Jian Liu
Concern about intracerebral hemorrhage (ICH) is the primary reason for withholding tPA therapy from patients with ischemic stroke. Early blood brain barrier (BBB) damage is the major risk factor for fatal post-thrombolysis ICH, but rapidly assessing BBB damage before tPA administration is highly challenging. We recently reported that ischemia induced rapid degradation of tight junction protein occludin in cerebromicrovessels. The present study investigates whether the cleaved occludin is released into the blood stream and how blood occludin levels correlate to the extent of BBB damage using a rat model of ischemic stroke...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28078728/radical-and-diradical-formation-in-naphthalene-diimides-through-simple-chemical-oxidation
#5
Sangsu Lee, Fang Miao, Hoa Phan, Tun Seng Herng, Jun Ding, Jishan Wu, Dongho Kim
We successfully synthesized, for the first time, naphthalene diimide (NDI) radical and diradical by simple chemical oxidation using lead (IV) dioxide. The formation of (di)radical is confirmed through UV/Vis/NIR absorption, 1H NMR and EPR measurements. In particular, temperature dependent EPR, SQUID and quantum calculations demonstrated that the generated NDI diradical has singlet diradical character of y = 0.69 in the ground state. Subsequent characterization of these (di)radical revealed their stabilities, large TPA cross-sections and short excited-state lifetimes...
January 12, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28073348/wild-carrot-pentane-based-fractions-suppress-proliferation-of-human-hacat-keratinocytes-and-protect-against-chemically-induced-skin-cancer
#6
Wassim N Shebaby, Mohamad A Mroueh, Petra Boukamp, Robin I Taleb Ri, Kikki Bodman-Smith, Mirvat El-Sibai, Costantine F Daher
BACKGROUND: Previous studies in our laboratory showed that the Lebanese Daucus carota ssp. carota (wild carrot) oil extract possesses in vitro and in vivo anticancer activities. The present study aims to examine the cytotoxic effect of Daucus carota oil fractions on human epidermal keratinocytes and evaluate the chemopreventive activity of the pentane diethyl ether fraction on DMBA/TPA induced skin carcinogenesis in mice. METHODS: Wild carrot oil extract was chromatographed to yield four fractions (F1, 100% pentane; F2, 50:50 pentane:diethyl ether; F3, 100% diethyl ether; F4 93:7 chloroform:methanol)...
January 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28064008/functional-response-of-novel-bioprotective-poloxamer-structured-vesicles-on-inflamed-skin
#7
Carla Caddeo, Maria Letizia Manca, Maria Matos, Gemma Gutierrez, Octavio Díez-Sales, José Esteban Peris, Iris Usach, Xavier Fernàndez-Busquets, Anna Maria Fadda, Maria Manconi
Resveratrol and gallic acid, a lipophilic and a hydrophilic phenol, were co-loaded in innovative, biocompatible nanovesicles conceived for ensuring the protection of the skin from oxidative- and inflammatory-related affections. The basic vesicles, liposomes and glycerosomes, were produced by a simple, one-step method involving the dispersion of phospholipid and phenols in water or water/glycerol blend, respectively. Liposomes and glycerosomes were modified by the addition of poloxamer, a stabilizer and viscosity enhancer, thus obtaining viscous or semisolid dispersions of structured vesicles...
January 4, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28062207/cardiometabolic-biomarkers-are-predictors-of-readmission-and-death-in-patients-hospitalized-for-acute-dyspnea
#8
Nathalie Lund, Klas Gränsbo, Camilla Wernersson, Olle Melander
BACKGROUND: Acute dyspnea affects a large heterogeneous patient group with high mortality and readmission rates. PURPOSE: To investigate if cardiometabolic biomarkers and clinical characteristics predict readmission and death in patients hospitalized for acute dyspnea. METHODS: 65 dyspnea patients at a general internal medicine ward were followed for six months. The combined endpoint was readmission or death. MEASUREMENTS AND RESULTS: Cardiometabolic biomarkers at admission were related to the endpoint in Cox proportional hazard models (adjusted for sex, age, oxygen saturation, respiratory rate and C-reactive protein (CRP))...
December 22, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28060391/intravitreal-versus-subretinal-tissue-plasminogen-activator-injection-for-submacular-hemorrhage
#9
James E Bell, Julia P Shulman, Russell J Swan, Michael P Teske, Paul S Bernstein
BACKGROUND AND OBJECTIVE: The objective of this study was to compare visual acuity outcomes between the following procedures used to treat submacular hemorrhages: pneumatic displacement followed by intravitreal tissue plasminogen activator (tPA) if needed (pneumatic ± tPA) and pars plana vitrectomy (PPV) with subretinal tPA (PPV + tPA). PATIENTS AND METHODS: This is a retrospective chart review of submacular hemorrhages treated with either pneumatic ± tPA or PPV + tPA...
January 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28060219/multicenter-study-of-adverse-events-after-intravenous-tissue-type-plasminogen-activator-treatment-of-acute-ischemic-stroke
#10
Hannah Fernandez-Gotico, Tiffany Lightfoot, Melissa Meighan
BACKGROUND AND PURPOSE: The approved treatment by the Food and Drug Administration for acute ischemic stroke is intravenous tissue-type plasminogen activator (IV tPA). After IV tPA administration, patients are monitored for adverse events using an American Heart Association/American Stroke Association guideline instituted in 1996. There is limited evidence describing the safest and most efficient method to monitor patients during the first 24 hours after tPA administration. Although the overall rates of adverse events have been reported, the time when patients may be at most risk for an event has not been studied...
February 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/28059331/optical-autocorrelation-performance-of-silicon-wire-p-i-n-waveguides-utilizing-the-enhanced-two-photon-absorption
#11
Guangwei Cong, Morifumi Ohno, Yuriko Maegami, Makoto Okano, Koji Yamada
Optical autocorrelation accuracy was for the first time analyzed for the silicon waveguide based autocorrelators utilizing two-photon absorption (TPA) under various short pulse conditions by numerical simulation. As for autocorrelation operation in the sub-μm silicon p-i-n rib waveguides on the 220 nm SOI (silicon on insulator) wafers, the autocorrelation error of pulse width measurement gradually increases with the increase of the peak power for both Gaussian and hyperbolic secant pulses due to the influence of free-carrier absorption (FCA)...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28059250/giant-nonlinear-absorption-and-excited-carrier-dynamics-of-black-phosphorus-few-layer-nanosheets-in-broadband-spectra
#12
Runze Chen, Yuhua Tang, Xin Zheng, Tian Jiang
Layered black phosphorus nanosheets (BPNs) offer potential uses in nanoelectronic and photonics applications. This work demonstrates giant saturable absorption (SA) and two-photon absorption (TPA) of BPNs under femtosecond visible-to-mid-infrared laser-pulse excitation. In addition, the excited carrier dynamics of BPNs were also studied with ultrafast pump-probe technology. Measurements demonstrated that the nonlinear absorption properties of BPNs strongly depend on excitation wavelength and intensity. BPNs moved from SA to TPA under increasing laser intensities at 800, 1160, 1300, and 1550 nm but showed a purely TPA response at 2000 nm, as gauged by measuring BPN nonlinear absorption coefficients...
December 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/28057008/correlates-of-preschool-children-s-objectively-measured-physical-activity-and-sedentary-behavior-a-cross-sectional-analysis-of-the-splashy-study
#13
Einat A Schmutz, Claudia S Leeger-Aschmann, Thomas Radtke, Stefanie Muff, Tanja H Kakebeeke, Annina E Zysset, Nadine Messerli-Bürgy, Kerstin Stülb, Amar Arhab, Andrea H Meyer, Simone Munsch, Jardena J Puder, Oskar G Jenni, Susi Kriemler
BACKGROUND: Identifying ways to promote physical activity and decrease sedentary time during childhood is a key public health issue. Research on the putative influences on preschool children's physical activity (PA) and sedentary behavior (SB) is limited and has yielded inconsistent results. Our aim was to identify correlates of PA and SB in preschool children. METHODS: Cross-sectional data were drawn from the Swiss Preschoolers' Health Study (SPLASHY), a Swiss population-based cohort study...
January 5, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28055194/nonredox-metal-ions-enhanced-dioxygen-activation-by-oxidovanadium-iv-complexes-toward-hydrogen-atom-abstraction
#14
Jisheng Zhang, Hang Yang, Tingting Sun, Zhuqi Chen, Guochuan Yin
Dioxygen activation toward efficient catalysis at ambient temperature is still a big challenge for industrial oxidations, while it proceeds smoothly in nature. This work presents an example of that adding nonredox metal ions as Lewis acid can enhance dioxygen activation by oxidovanadium(IV) complex, [V(IV)(O)Cl(TPA)]PF6 (where TPA is tris-[(2-pyridy)methyl]amine), which leads to efficient hydrogen abstraction at ambient temperature, whereas, in the absence of a Lewis acid, the catalytic hydrogen abstraction of the oxidovanadium(IV) complex is very sluggish...
January 5, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28053009/progressive-rural-urban-disparity-in-acute-stroke-care
#15
Sergio Gonzales, Michael T Mullen, Leslie Skolarus, Dylan P Thibault, Uduak Udoeyo, Allison W Willis
OBJECTIVE: To explore rural-urban differences and trends in tissue plasminogen activator (tPA) utilization among acute ischemic stroke (AIS) patients and examine the association between primary stroke center (PSC) growth and geographic disparity in tPA use. METHODS: We used hospital discharge data from the National Inpatient Sample (NIS) from 2000 to 2010 and indicators of tPA utilization and describe temporal trends in geographic disparities in AIS care during PSC growth...
January 4, 2017: Neurology
https://www.readbyqxmd.com/read/28051346/a-conjugate-of-two-tpa-binding-rna-aptamers-efficiently-inhibits-fibrinolysis
#16
Nils Bjerregaard, Daniel M Dupont, Peter A Andreasen
Uncontrolled bleeding is a major cause of mortality. Lysine analogues are routinely used in the management of bleeding, but several studies indicate a risk of serious detrimental effects upon their administration. In this study, we report a bivalent conjugate "3218" of two RNA aptamers selected for binding to the serine protease tissue-type plasminogen activator (tPA), the principal initiator of fibrinolysis in mammals. The constituent monomeric aptamers, K32v2 and K18v2, were previously demonstrated to weakly inhibit fibrinolysis...
January 4, 2017: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/28051260/the-application-value-of-the-detection-of-the-level-of-tissue-polypeptide-antigen-ovarian-cancer-antigen-x1-cathepsin-l-and-ca125-on-the-diagnosis-of-epithelial-ovarian-cancer
#17
X-L Lv, Y Zhu, J-W Liu, H Ai
OBJECTIVE: We investigated the value of the joint detection of tissue polypeptide antigen (TPA), ovarian cancer antigen X1 (OVX1), cathepsin L (CTSL) and CA125 on the early diagnosis of epithelial ovarian carcinoma (EOC). PATIENTS AND METHODS: From October 2011 to February 2015, 84 cases of patients under surgical treatment of epithelial ovarian cancer, 98 cases of patients with benign epithelial ovarian tumor and 51 subjects in healthy control group were selected to detect the level of TPA, OVX1 and CTSL in serum from the Obstetrics and Gynecology Department of the First Affiliated Hospital of Liaoning Medical University...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28045545/multistep-oxidation-of-diethynyl-oligophenylamine-bridged-diruthenium-and-diiron-complexes
#18
Jing Zhang, Shen-Zhen Guo, Yu-Bao Dong, Li Rao, Jun Yin, Guang-Ao Yu, František Hartl, Sheng Hua Liu
Homo-dinuclear nonlinear complexes [{M(dppe)Cp*}2{μ-(-C≡C)2X}] (dppe = 1,2-bis(diphenylphosphino)ethane; Cp* = η(5)-C5Me5; X = triphenylamine (TPA), M = Ru (1a) and Fe (1b); X = N,N,N',N'-tetraphenylphenylene-1,4-diamine (TPPD), M = Ru (2a)) were prepared and characterized by (1)H, (13)C, and (31)P NMR spectroscopy and single-crystal X-ray diffraction (1a, 2a). Attempts to prepare the diiron analogue of 2a were not successful. Experimental data obtained from cyclic voltammetry, square wave voltammetry, UV-vis-NIR (NIR = near-infrared) spectro-electrochemistry, and very informative IR spectro-electrochemistry in the C≡C stretching region, combined with density functional theory calculations, afford to make an emphasizing assessment of the close association between the metal-ethynyl termini and the oligophenylamine bridge core as well as their respective involvement in sequential one-electron oxidations of these complexes...
January 3, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28042267/comparison-of-temporary-anchorage-devices-and-transpalatal-arch-mediated-anchorage-reinforcement-during-canine-retraction
#19
Defne Kecik
OBJECTIVE: The purpose of this study was to compare the dental and skeletal effects of canine retraction using conventional anchorage reinforcement systems and comparing them with the usage of TADs. MATERIALS AND METHODS: The sample consisted of 50 patients having Class I malocclusions with bimaxillary protrusion indicated for first premolar extraction, and allocated into two groups. The first group consisted of 25 patients with a mean age of 18,7 years (min:14, max:22 years, 16 girls and 9 boys) that TADs were applied as an anchorage mechanic between attached gingiva of upper second premolar and first molar teeth...
October 2016: European Journal of Dentistry
https://www.readbyqxmd.com/read/28035779/reduction-of-intracerebral-hemorrhage-by-rivaroxaban-after-tpa-thrombolysis-is-associated-with-downregulation-of-par-1-and-par-2
#20
Ryuta Morihara, Toru Yamashita, Syoichiro Kono, Jingwei Shang, Yumiko Nakano, Kota Sato, Nozomi Hishikawa, Yasuyuki Ohta, Stefan Heitmeier, Elisabeth Perzborn, Koji Abe
This study aimed to assess the risk of intracerebral hemorrhage (ICH) after tissue-type plasminogen activator (tPA) treatment in rivaroxaban compared with warfarin-pretreated male Wistar rat brain after ischemia in relation to activation profiles of protease-activated receptor-1, -2, -3, and -4 (PAR-1, -2, -3, and -4). After pretreatment with warfarin (0.2 mg/kg/day), low-dose rivaroxaban (60 mg/kg/day), high-dose rivaroxaban (120 mg/kg/day), or vehicle for 14 days, transient middle cerebral artery occlusion was induced for 90 min, followed by reperfusion with tPA (10 mg/kg/10 ml)...
December 30, 2016: Journal of Neuroscience Research
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