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insulin inje

Cathryn M Kolka, L Nicole Harrison, Maya Lottati, Jenny D Chiu, Erlinda L Kirkman, Richard N Bergman
OBJECTIVE: Obesity causes insulin resistance, which has been interpreted as reduced downstream insulin signaling. However, changes in access of insulin to sensitive tissues such as skeletal muscle may also play a role. Insulin injected directly into skeletal muscle diffuses rapidly through the interstitial space to cause glucose uptake. When insulin resistance is induced by exogenous lipid infusion, this interstitial diffusion process is curtailed. Thus, the possibility exists that hyperlipidemia, such as that seen during obesity, may inhibit insulin action to muscle cells and exacerbate insulin resistance...
March 2010: Diabetes
T Laursen, C H Gravholt, L Heickendorff, J Drustrup, A M Kappelgaard, J O Jørgensen, J S Christiansen
It remains uncertain whether close imitation of the physiological pulsatile GH pattern determines the effects of GH treatment in humans. However, human studies have reported comparable metabolic responses to short-term constant and intermittent GH exposure. The aim of the study was to compare the metabolic effects of GH after continuous and intermittent sc delivery. In a parallel design, 14 GH-treated GH-deficient patients (mean age, 37 yr; mean body mass index, 27.4 kg/m(2)) were studied during steady state at the start of the study and after 6 months...
March 2001: Journal of Clinical Endocrinology and Metabolism
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