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https://www.readbyqxmd.com/read/28327160/what-constitutes-problematic-khat-use-an-exploratory-mixed-methods-study-in-ethiopia
#1
Awoke Mihretu, Solomon Teferra, Abebaw Fekadu
BACKGROUND: Khat is a psycho-stimulant herb, which has been in use in traditional societies in East Africa and the Middle East over many centuries. Although khat is reported to cause various health problems, what constitutes problematic khat use has never been systematically investigated. This study explored the acceptable and problematic uses of khat from the perspective of users. METHODS: The study used a mixed methods design (exploratory sequential) in which qualitative (emic) data were collected to develop a framework to define problematic khat use...
March 21, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28321455/comorbid-psychopathology-and-everyday-functioning-in-a-brief-intervention-study-to-reduce-khat-use-among-somalis-living-in-kenya-description-of-baseline-multimorbidity-its-effects-of-intervention-and-its-moderation-effects-on-substance-use
#2
Marina Widmann, Bernice Apondi, Abednego Musau, Abdulkadir Hussein Warsame, Maimuna Isse, Victoria Mutiso, Clemens Veltrup, David Ndetei, Michael Odenwald
BACKGROUND AND AIMS: Migration and khat use were found to correlate with high rates of psychopathology. In this paper we aimed for assessing baseline multimorbidity and its interactions with a Brief Intervention. METHODS: In the RCT, 330 male Somali khat users were assigned to treatment conditions (khat use is a predominantly male habit). The ASSIST-linked BI for khat users was administered. Using the TLFB Calendar, the PHQ-9, a Somali short version of the PDS and parts from the CIDI, khat use and comorbidity was assessed...
March 20, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28316587/characterization-of-the-antinociceptive-mechanisms-of-khat-extract-catha-edulis-in-mice
#3
Elham A Afify, Huda M Alkreathy, Ahmed S Ali, Hassan A Alfaifi, Lateef M Khan
This study investigated the antinociceptive mechanisms of khat extract (100, 200, and 400 mg/kg, i.p.) in four pain models: two thermic (hot plate, tail-flick) and two chemical (acetic acid, formalin) models. Male mice were pretreated intraperitoneally (i.p.) with the opioid receptor blocker naloxone (5 mg/kg), the cholinergic antagonist atropine (2 mg/kg), the selective α1 blocker prazosin (1 mg/kg), the dopamine D2 antagonist haloperidol (1.5 mg/kg), or the GABAA receptor antagonist, bicuculline (1 mg/kg) 15 minutes prior to i...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28265577/perceived-psychological-economic-and-social-impact-of-khat-chewing-among-adolescents-and-adults-in-nekemte-town-east-welega-zone-west-ethiopia
#4
Amsalu Taye Wondemagegn, Melese Chego Cheme, Kelemu Tilahun Kibret
The main aim of this study was to assess psychological, economic, and social impact of khat chewing among adolescents, in Nekemte town, East Welega Zone. A community based cross-sectional study was conducted from March to June 2016 using both quantitative and qualitative methods of data collection. A total of 359 samples were included in the study. A pretested, interviewer based structured questionnaire was employed during data collection. The study found the current prevalence of khat chewing practices was 48...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28258271/patterns-of-restorative-failure-among-khat-and-shammah-users-in-jazan-city-kingdom-of-saudi-arabia-a-cross-sectional-survey
#5
Mohammed E Sayed, Razan A Bosly, Huda A Hakami, Maryam H Mugri, Shilpa H Bhandi
INTRODUCTION: The effect of Khat and Shammah habits, with the parafunctional jaw activities that accompany them, on the integrity of the natural dentition, dental restorations, and prostheses has not yet been investigated. This study is the first attempt to identify the patterns of restorative failure among Khat chewers and Shammah users in Jazan City, Kingdom of Saudi Arabia. MATERIALS AND METHODS: A cross-sectional study was conducted in 294 recruits among dental clinics in Jazan City, Kingdom of Saudi Arabia, from October 1, 2015, to April 30, 2016...
March 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28149078/toxic-effect-of-khat-catha-edulis-on-memory-systematic-review-and-meta-analysis
#6
Birhane Alem Berihu, Gebrekidan Gebregzabher Asfeha, Abadi Leul Welderufael, Yared Godefa Debeb, Yibrah Berhe Zelelow, Hafte Assefa Beyene
BACKGROUND: People use khat (Catha edulis) for its pleasant stimulant effect of physical activity, consciousness, motor, and mental functions. Although there are reports assessing the effect of khat on memory, there was no study based on formal systematic review and meta-analysis. OBJECTIVE: We have therefore conducted this meta-analysis to determine the level of evidence for the effect of khat (C. edulis Forsk) on memory discrepancy. METHODS: MEDLINE, Cochrane Library, PubMed, Academic Search Complete, SPORTDiscus, ScienceDirect, Scopus, Web of Science, and Google Scholar were searched to retrieve the papers for this review...
January 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28124803/employing-two-stage-derivatisation-and-gc-ms-to-assay-for-cathine-and-related-stimulant-alkaloids-across-the-celastraceae
#7
Luke R Tembrock, Corey D Broeckling, Adam L Heuberger, Mark P Simmons, Frank R Stermitz, Jessica M Uvarov
INTRODUCTION: Catha edulis (qat, khat, mirra) is a woody plant species that is grown and consumed in East Africa and Yemen for its stimulant alkaloids cathinone, cathine and norephedrine. Two Celastraceae species, in addition to qat, have been noted for their stimulant properties in ethnobotanical literature. Recent phylogenetic reconstructions place four genera in a clade sister to Catha edulis, and these genera are primary candidates to search for cathine and related alkaloids. OBJECTIVE: Determine if cathine or related alkaloids are present in species of Celastraceae other than Catha edulis...
January 26, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28057187/challenges-in-laboratory-detection-of-unusual-substance-abuse-issues-with-magic-mushroom-peyote-cactus-khat-and-solvent-abuse
#8
A Dasgupta
Drug abuse is a worldwide problem. Although commonly abused drugs can be identified during routine urine drug testing, less commonly abused drugs may escape detection. These less commonly abused drugs not only include some designer drugs such as synthetic cannabinoid but also include abuse of psychedelic magic mushroom (active ingredients: psilocybin and psilocin), peyote cactus (active ingredient: mescaline), and khat plants (active ingredient: cathinone). Moreover, solvent and glue abuse is gaining popularity among teenagers and young adults which may even cause fatality...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28057079/prevalence-and-factors-associated-with-use-of-khat-a-survey-of-patients-entering-hiv-treatment-programs-in-ethiopia
#9
Alan R Lifson, Sale Workneh, Tibebe Shenie, Desalegn Admassu Ayana, Zenebe Melaku, Lemlem Bezabih, Hiwot Tekle Waktola, Behailu Dagne, Rose Hilk, Ken C Winters, Lucy Slater
BACKGROUND: Khat, a plant native to East Africa, has psychoactive constituents similar to amphetamine. Chronic khat use can lead to psychological dependence with multiple physical and mental health harms, complicating clinical management of people living with HIV. In two Ethiopian cities where khat is common, we evaluated prevalence and correlates of khat use among patients new to HIV care. METHODS: During 2013-2014, we surveyed 322 patients recently enrolled in HIV clinics in Dire Dawa and Harar about khat use, demographics, smoking and alcohol use, clinical illness, food insecurity, and social support...
January 6, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/28053661/psychological-morbidity-and-substance-use-among-patients-with-hypertension-a-hospital-based-cross-sectional-survey-from-south-west-ethiopia
#10
Matiwos Soboka, Esayas Kebede Gudina, Markos Tesfaye
BACKGROUND: Psychological morbidity and substance use disorders have been linked to cardiovascular diseases; affecting patients' medical outcome and quality of life. However, little is known about psychological morbidity and substance use among patients with hypertension in Ethiopia. Therefore, we aimed to assess psychological comorbidity and substance use among hypertensive patients in Southwest Ethiopia. METHODS: A cross-sectional study was conducted among 396 hypertensive patients on follow-up at Jimma University Teaching Hospital in Ethiopia during the study period...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28050980/prevalence-and-severity-of-temporomandibular-disorders-among-undergraduate-medical-students-in-association-with-khat-chewing
#11
Mohammed M Al Moaleem, Abdulmajeed S Okshah, Ahid A Al-Shahrani, Abdulkhaliq Ali F Alshadidi, Fawzia I Shaabi, Abdulaziz H Mobark, Khurshid A Mattoo
INTRODUCTION: The aim of this study was to assess the prevalence and severity of temporomandibular joint disorders (TMDs) among undergraduate medical students in the presence of khat chewing over a period of time. MATERIALS AND METHODS: Totally, 186 medical college students (age < 20 years) were randomly selected for the present study. The study subjects were divided into two groups according to age, under 20 and above 20 years. The study was based on Fonseca's anamnestic index and its questionnaire, which is composed of 10 questions and classifies the severity of TMDs...
January 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28043552/role-of-socio-demographical-factors-on-tuberculosis-outcome-in-yemen
#12
Ammar Ali Saleh Jaber, Amer Hayat Khan, Syed Azhar Syed Sulaiman, Nafees Ahmad
OBJECTIVES: Tuberculosis (TB) is an infection disease caused by an organism called Mycobacterium tuberculosis (tubercle bacilli). Tuberculosis remains the most common infection worldwide (Organization & World Health Organization, 2013). Yemen situated in WHO Eastern Mediterranean Region and ranked as intermediate TB-burdened countries. TB considers as one of the main health problems; it ranks as the fourth in the priority of the public health issue (NTCP, 2010). The study was conducted to evaluate the Socio-Demographical variables on tuberculosis treatment outcome...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27978853/khat-a-new-precipitating-factor-for-reversible-cerebral-vasoconstriction-syndrome-a-case-report
#13
Harith Baharith, Amy Zarrin
BACKGROUND: Postpartum reversible cerebral vasoconstriction syndrome is one of the rare reversible cerebral vasoconstriction syndromes. The clinical presentation is usually characterized by recurrent headache, focal neurological deficit, and reversible cerebral vasoconstriction seen on cerebral angiography. CASE PRESENTATION: We report a case of a 35-year-old Yemeni woman who presented with headache and focal neurological deficits that occurred 10 days after delivery, with segmental narrowing of cerebral arteries on angiography...
December 15, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27917217/determinants-of-alcohol-use-and-khat-chewing-among-hawassa-university-students-ethiopia-a-cross-sectional-study
#14
Andargachew Kassa, Negash Wakgari, Fiker Taddesse
BACKGROUND: Students' alcohol and khat use have been associated with various health related problems. However, its magnitude and associated factors among Ethiopian students are not yet well documented. OBJECTIVE: The study aimed to assess the prevalence of alcohol use, khat chewing and its associated factors among Hawassa University students. METHODS: A cross-sectional study was conducted from June to July 2011. Multistage stratified sampling technique was employed to select 590 students...
September 2016: African Health Sciences
https://www.readbyqxmd.com/read/27871070/khat-catha-edulis-and-obesity-a-scoping-review-of-animal-and-human-studies
#15
Mustafa Ahmed Alshagga, Mohammed Abdullah Alshawsh, Atefehalsadat Seyedan, Abdulsamad Alsalahi, Yan Pan, Suresh Kumar Mohankumar, Abdolgodose Alkebsi, Saba Kassim, Zahurin Mohamed
BACKGROUND: Khat (Catha edulis) is a plant that is deeply rooted in the cultural life of East African and Southwestern Arabian populations. Prevalent traditional beliefs about khat are that the plant has an effect on appetite and body weight. SUMMARY: This review assesses the accumulated evidences on the mutual influence of monoamines, hormones and neuropeptides that are linked to obesity. A few anti-obesity drugs that exert their mechanisms of action through monoamines are briefly discussed to support the notion of monoamines being a critical target of drug discovery for new anti-obesity drugs...
2016: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/27785113/projection-neurons-in-the-cortex-and-hippocampus-differential-effects-of-chronic-khat-and-ethanol-exposure-in-adult-male-rats
#16
Paul E Alele, Daniel Matovu, Lawrence Imanirampa, Abayomi M Ajayi, Gyaviira T Kasule
BACKGROUND: Recent evidence suggests that many individuals who chew khat recreationally also drink ethanol to offset the stimulating effect of khat. The objective of this study was to describe the separate and interactive effects of chronic ethanol and khat exposure on key projection neurons in the cortex and hippocampus of young adult male rats. METHODS: Young adult male Sprague Dawley rats were divided into six treatment groups: 2 g/kg khat, 4 g/kg khat, 4 g/kg ethanol, combined khat and ethanol (4 g/kg each), a normal saline control, and an untreated group...
2016: Journal of Experimental Pharmacology
https://www.readbyqxmd.com/read/27761074/catha-edulis-khat-induces-apoptosis-in-madin-darby-bovine-kidney-cell-line
#17
Hussein M Ageely, Ahmed E Agag, Syam Mohan, Atef Shehata
BACKGROUND: Khat (Catha edulis) is a controversial plant having a euphoretic effect, at the same time part of culture in many countries such as Africa and Arabian Peninsula. The presence of amphetamine-like substance, cathinone and cathine make this plant banned in many countries. Many neurological and other system related studies have been carried out in this plant, but the lack of toxicity studies are there especially the mechanism. OBJECTIVE: In this study, Madin-Darby Bovine Kidney cell line was used as an in vitro model to study the cell death mechanism...
July 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27616032/isolation-and-in-vitro-permeation-of-phenylpropylamino-alkaloids-from-khat-catha-edulis-across-oral-and-intestinal-mucosal-tissues
#18
Minaleshewa Atlabachew, Sandra Combrinck, Alvaro M Viljoen, Josias H Hamman, Chrisna Gouws
ETHNOPHARMACOLOGICAL RELEVANCE: Khat, the leaves of Catha edulis, is used as a "natural amphetamine-like" stimulant in eastern and southern Africa, as well as in the Arabian Peninsula. Leaves are masticated to elicit a state of euphoria. Although the psychostimulatory effects of the leaves are attributed to the presence of phenylpropylamino alkaloids (i.e. cathinone, cathine and norephedrine), the extent of permeation of these alkaloids across the oral and intestinal mucosa has not been established...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27608556/khat-and-cancer
#19
Mahantayya V Math, Yashoda R Kattimani
No abstract text is available yet for this article.
September 9, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27582041/factors-associated-with-secondhand-tobacco-smoke-in-the-home-an-exploratory-cross-sectional-study-among-women-in-aleta-wondo-ethiopia
#20
Anne Berit Petersen, Lisa M Thompson, Gezahegn Bekele Dadi, Alemu Tolcha, Janine K Cataldo
BACKGROUND: In Ethiopia, female smoking rates are currently low (1 %). However, because of male smoking rates (overall 7.7 % and up to 27 % depending on region), women and children's risk of second hand smoke (SHS) exposure is a pressing concern. In order to develop effective public health interventions that prevent the uptake and exposure to smoking, thereby averting the projected increase in tobacco-induced disease, an understanding of Ethiopian women's practices regarding tobacco is needed...
2016: BMC Public Health
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