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Platelet Rich Plasma Therapy

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https://www.readbyqxmd.com/read/29141627/in-vitro-properties-of-concentrated-canine-platelets-stored-in-two-additive-solutions-a-comparative-study
#1
N Hlavac, C S Lasta, M L Dalmolin, L A Lacerda, D de Korte, N A Marcondes, S R Terra, F B Fernandes, F H D González
BACKGROUND: Platelet transfusion therapy poses many challenges in veterinary clinical practice. Lack of readily available blood donors, short shelf-life, and inability to administer a sufficient number of platelets to meet a dog's transfusion need are the major difficulties encountered. Platelet additive solutions are already in use at American and European human blood banks, showing to be a realistic alternative. This study compares the in vitro platelet function in plasma, Composol, or SSP+ during storage for 13 days...
November 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29118521/a-proposal-of-an-effective-platelet-rich-plasma-protocol-for-the-treatment-of-androgenetic-alopecia
#2
Juan Ferrando, Sandra Cecilia García-García, Ana Cecilia González-de-Cossío, Lola Bou, Esperanza Navarra
Background: Platelet-rich plasma (PRP) has emerged as a promising treatment for androgenetic alopecia (AGA). In spite of the several studies previously reported, to date, a standardized protocol for PRP preparation and application, as well as a standard method for evaluating results has not been established. Aims: The aim of this study is to propose a standardized method for preparation and application of PRP for male AGA (MAGA) and female AGA (FAGA) and assess its safety and efficacy as a co-adjuvant therapy...
October 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/29108548/new-generation-therapies-for-the-treatment-of-hair-loss-in-men
#3
REVIEW
Neil S Sadick
Hair loss affects millions of people worldwide and can have devastating effects on an individual's psychoemotional well-being. Today hair restoration technologies through hair transplantation have advanced with the use of robots and follicular unit extraction/grafting that can offer patients excellent clinical results. Adjuvant modalities, such as platelet-rich plasma injections, lasers, and stem cells, can further enhance durability, health, and appearance of hair transplants.
January 2018: Dermatologic Clinics
https://www.readbyqxmd.com/read/29101437/comparison-of-the-efficacy-of-homologous-and-autologous-platelet-rich-plasma-prp-for-treating-androgenic-alopecia
#4
Bilsev Ince, Mehmet Emin Cem Yildirim, Mehmet Dadaci, Mustafa Cihat Avunduk, Nedim Savaci
BACKGROUND: Androgenetic alopecia (AGA), the most common cause of hair loss in both sexes, accounts for 95% of all cases of hair loss. Although the literature has suggested that both nonactivated (n-PRP) and activated autologous (a-PRP) PRP can be used to treat AGA, we did not find any study investigating the use of homologous PRP (h-PRP) for this purpose. Also, to the best of our knowledge, there are no studies comparing the efficacy of h-PRP, a-PRP, or n-PRP on AGA therapy. OBJECTIVES: The aim of this study was to compare the increase in hair density, average number of platelets, complications, preparation, and duration of application in the treatment of AGA using a-PRP, n-PRP, and h-PRP...
November 3, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29095303/platelet-rich-plasma-as-a-treatment-for-plantar-fasciitis-a-meta-analysis-of-randomized-controlled-trials
#5
REVIEW
Wei-Yi Yang, Yan-Hong Han, Xue-Wei Cao, Jian-Ke Pan, Ling-Feng Zeng, Jiong-Tong Lin, Jun Liu
BACKGROUND: Recently, platelet-rich plasma (PRP) has been used as an alternative therapy for plantar fasciitis (PF) to reduce heel pain and improve functional restoration. We evaluated the current evidence concerning the efficacy and safety of PRP as a treatment for PF compared with the efficacy and safety of steroid treatments. METHODS: Databases (PubMed, EMBASE, and The Cochrane Library) were searched from their establishment to January 30, 2017, for randomized controlled trials (RCTs) comparing PRP with steroid injections as treatments for PF...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29090039/platelet-carbonic-anhydrase-ii-a-forgotten-enzyme-may-be-responsible-for-aspirin-resistance
#6
M Jakubowski, J Dębski, E Szahidewicz-Krupska, A Turek-Jakubowska, J Gawryś, K Gawryś, R Skomro, A Derkacz, A Doroszko
BACKGROUND: Thromboembolic events constitute a major health problem, despite the steadily expanding arsenal of antiplatelet drugs. Hence, there is still a need to optimize the antiplatelet therapy. OBJECTIVES: The aim of our study was to verify a hypothesis that there are no differences in platelet proteome between two groups of healthy people representing different acetylsalicylic acid (aspirin) responses as assessed by the liquid chromatography/mass spectrometry (LC/MS) technique...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29076317/salvage-of-unilateral-complete-ear-amputation-with-continuous-local-hyperbaric-oxygen-platelet-rich-plasma-and-polydeoxyribonucleotide-without-micro-revascularization
#7
Sang Keon Lee, Yoon Min Lim, Dae Hyun Lew, Seung Yong Song
In many cases of complete ear amputation, microvascular surgery is required for tissue perfusion and organ survival. However, microvascular reconstruction is not always feasible in the absence of suitable vessels. Here, we present the case of a 76-year-old man who underwent complete amputation of the left ear after a collapse at home because of cardiogenic syncope. He was treated with primary replantation and underwent a postoperative salvage course including continuous local hyperbaric oxygen therapy (HBOT), platelet-rich plasma (PRP) injections, and polydeoxyribonucleotide (PDRN) injections...
October 27, 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/29076239/use-of-epidermal-skin-grafts-in-chronic-wounds-a-case-series
#8
Peter Am Everts, Marco Warbout, Diana de Veth, Merel Cirkel, Nicole E Spruijt, Jaap Buth
In stalled, chronic wounds, more aggressive and proactive wound closure efforts are needed. We describe adjunctive use of epidermal grafting in patients with chronic wounds. Wound bed preparation consisted of surgical necrotectomy or sharp debridement, hyperbaric oxygen therapy, negative pressure wound therapy, compression therapy, platelet-rich plasma therapy and/or heparan sulphate agents. Epidermal grafts were harvested from the patient's thigh and applied to the wound. Wound and donor site healing was monitored...
October 27, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29064980/hair-transplantation-controversies
#9
REVIEW
Marc R Avram, Robert Finney, Nicole Rogers
BACKGROUND: Hair transplant surgery creates consistently natural appearing transplanted hair for men. It is increasingly popular procedure to restore natural growing hair for men with hair loss. OBJECTIVE: To review some current controversies in hair transplant surgery. MATERIALS AND METHODS: Review of the English PubMed literature and specialty literature in hair transplant surgery. RESULTS: Some of the controversies in hair transplant surgery include appropriate donor harvesting technique including elliptical donor harvesting versus follicular unit extraction whether manual versus robotic, the role of platelet-rich plasma and low-level light surgery in hair transplant surgery...
November 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29058626/combined-platelet-rich-plasma-and-lipofilling-treatment-provides-great-improvement-in-facial-skin-induced-lesion-regeneration-for-scleroderma-patients
#10
Francesco Virzì, Paola Bianca, Alessandro Giammona, Tiziana Apuzzo, Simone Di Franco, Laura Rosa Mangiapane, Maria Luisa Colorito, Dario Catalano, Emanuela Scavo, Annalisa Nicotra, Antonina Benfante, Giuseppe Pistone, Valentina Caputo, Francesco Dieli, Roberto Pirrello, Giorgio Stassi
BACKGROUND: The use of stem cells, including mesenchymal stem cells (MSCs), for regenerative medicine is gaining interest for the clinical benefits so far obtained in patients. This study investigates the use of adipose autologous tissue in combination with platelet-rich plasma (PRP) to improve the clinical outcome of patients affected by systemic sclerosis (SSc). METHODS: Adipose-derived mesenchymal stem cells (AD-MSCs) and PRPs were purified from healthy donors and SSc patients...
October 23, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29058255/platelet-rich-plasma-combinational-treatment-modalities-for-musculoskeletal-conditions
#11
REVIEW
Isabel Andia, Michele Abate
Current research on common musculoskeletal problems, including osteoarticular conditions, tendinopathies, and muscle injuries, focuses on regenerative translational medicine. Platelet-rich plasma therapies have emerged as a potential approach to enhance tissue repair and regeneration. Platelet-rich plasma application aims to provide supraphysiological concentrations of platelets and optionally leukocytes at injured/pathological tissues mimicking the initial stages of healing. However, the efficacy of platelet-rich plasma is controversial in chronic diseases because patients' outcomes show partial improvements...
October 18, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29044680/effects-of-three-blood-derived-products-on-equine-corneal-cells-an-in-vitro-study
#12
J O Rushton, E Kammergruber, A Tichy, M Egerbacher, B Nell, S Gabner
BACKGROUND: Despite advances in therapy of corneal ulcerative diseases in horses, a vast number of cases require surgical intervention, due to poor response to treatment. Topical application of serum has been used for many years, based on its anti-collagenolytic properties and the presence of growth factors promoting corneal wound healing. However, although other blood derived products i.e. platelet rich plasma (PRP), plasma rich in growth factors (PRGF) have been widely used in equine orthopaedics and in human ophthalmology, no reports of the effects of these blood derived products exist in equine ophthalmology...
October 16, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29019941/the-contribution-of-adipose-tissue-derived-mesenchymal-stem-cells-and-platelet-rich-plasma-to-the-treatment-of-chronic-equine-laminitis-a-proof-of-concept
#13
Mario Angelone, Virna Conti, Cristiano Biacca, Beatrice Battaglia, Laura Pecorari, Francesco Piana, Giacomo Gnudi, Fabio Leonardi, Roberto Ramoni, Giuseppina Basini, Silvia Dotti, Sabrina Renzi, Maura Ferrari, Stefano Grolli
Laminitis, a highly debilitating disease of the foot in ungulates, is characterized by pathological changes of the complex lamellar structures that maintain the appendicular skeleton within the hoof. Laminitis is a multifactorial disease that involves perturbation of the vascular, hematological, and inflammatory homeostasis of the foot. Interestingly, the pathogenesis of the disease resembles what is observed in metabolic syndromes and sepsis-induced organ failure in humans and animals. We hypothesized that local administration of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) might contribute to establishing an anti-inflammatory and pro-angiogenic environment, and could stimulate the injured tissue in order to restore its functional integrity...
October 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29019594/allogeneic-mesenchymal-stem-cells-and-xenogenic-platelet-rich-plasma-associated-or-not-in-the-repair-of-bone-failures-in-rabbits-with-secondary-osteoporosis
#14
Mariá Andrade de Carvalho Rocha, Laís Meireles Costa Silva, Wellson Andrade de Oliveira, Dayseanny de Oliveira Bezerra, Gustavo Cardoso da Silva, Lucilene Dos Santos Silva, Brenda Lurian do Nascimento Medeiros, Sílvia de Araújo França Baêta, Maria Acelina Martins de Carvalho, Napoleão Martins Argôlo
PURPOSE: To assess the efficacy of allogeneic mesenchymal stem cells and xenogenic platelet rich plasma in the treatment of bone failure of osteoporotic rabbits secondary to estrogenic deprivation and iatrogenic hypercortisolism. METHODS: Eight female rabbits underwent ovarian resection and corticoid therapy to induce clinical status of osteoporosis. Four failures were produced in the tibiae, with each failure being treated with hemostatic sponge, allogenic mesenchymal stem cells, xenogenic platelet-rich plasma and the association between both...
September 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29018808/tenogenically-induced-allogeneic-peripheral-blood-mesenchymal-stem-cells-in-allogeneic-platelet-rich-plasma-2-year-follow-up-after-tendon-or-ligament-treatment-in-horses
#15
Charlotte Beerts, Marc Suls, Sarah Y Broeckx, Bert Seys, Aurélie Vandenberghe, Jeroen Declercq, Luc Duchateau, Martin A Vidal, Jan H Spaas
Poor healing of tendon and ligament lesions often results in early retirement of sport horses. Therefore, regenerative therapies are being explored as potentially promising treatment for these injuries. In this study, an intralesional injection was performed with allogeneic tenogenically induced mesenchymal stem cells and platelet-rich plasma 5-6 days after diagnosis of suspensory ligament (SL) (n = 68) or superficial digital flexor tendon (SDFT) (n = 36) lesion. Clinical, lameness and ultrasonographic evaluation was performed at 6 and 12 weeks...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28993845/-new-experimental-strategies-in-cartilage-surgery
#16
REVIEW
L Rackwitz, J C Reichert, O Pullig, U Nöth
BACKGROUND: Cell and growth factor based strategies bear great potential to support the healing processes in cartilage repair and the therapy of osteoarthritic joints. OBJECTIVES: The following review provides an overview of novel experimental strategies for the therapy of focal cartilage defects and osteoarthritis, with emphasis on cell and growth factor based approaches. MATERIALS AND METHODS: The authors summarize their own data regarding the intraarticular injection of stem cells to treat osteoarthritis of the knee and provide a synopsis of the available literature discussing the most significant publications...
November 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28980027/-insertional-achilles-tendinopathy-differentiated-diagnostics-and-therapy
#17
REVIEW
S F Baumbach, M Braunstein, M G Mack, F Maßen, W Böcker, S Polzer, H Polzer
Achilles tendinopathy at the calcaneal insertion is classified into insertional tendinopathy, retrocalcaneal and superficial bursitis. The aim of this study was to present the current evidence on conservative and surgical treatment of insertional tendinopathy of the Achilles tendon. Conservative first-line therapy includes reduction of activity levels, administration of non-steroidal anti-inflammatory drugs (NSAID), adaptation of footwear, heel wedges and orthoses or immobilization. In addition, further conservative therapy options are also available...
October 4, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28979149/conventional-and-novel-stem-cell-based-therapies-for-androgenic-alopecia
#18
REVIEW
Dodanim Talavera-Adame, Daniella Newman, Nathan Newman
The prevalence of androgenic alopecia (AGA) increases with age and it affects both men and women. Patients diagnosed with AGA may experience decreased quality of life, depression, and feel self-conscious. There are a variety of therapeutic options ranging from prescription drugs to non-prescription medications. Currently, AGA involves an annual global market revenue of US$4 billion and a growth rate of 1.8%, indicating a growing consumer market. Although natural and synthetic ingredients can promote hair growth and, therefore, be useful to treat AGA, some of them have important adverse effects and unknown mechanisms of action that limit their use and benefits...
2017: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/28967470/involvement-of-synovial-matrix-degradation-and-angiogenesis-in-oxidative-stress-exposed-degenerative-rotator-cuff-tears-with-osteoarthritis
#19
Kyu-Cheol Noh, Sin-Hye Park, Cheol Jung Yang, Geun Woo Lee, Min Ki Kim, Young-Hee Kang
BACKGROUND: Shoulder osteoarthritis is a gradual wearing of the articular cartilage concomitant with degenerative rotator cuff tears (RCTs). This pathologic disorder is related to inflammation, oxidative stress, and angiogenesis. Degenerative alterations may prompt production of cytokines and angiogenesis-related proteins, evoking rotator cuff diseases. This study tested the hypothesis that oxidative stress-responsive mediators can influence joint inflammation of patients with RCT. METHODS: Twelve healthy RCT patients not suffering shoulder osteoarthritis were categorized as the control group, and 24 patients were allocated to 2 RCT groups (RCTP1 and RCTP2), according to severity of RCT and glenohumeral arthritis...
September 26, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28960123/assessment-of-platelet-function-on-the-routine-coagulation-analyzer-sysmex-cs-2000i
#20
Corinne Frère, Katsushi Kobayashi, Claire Dunois, Jean Amiral, Pierre-Emmanuel Morange, Marie-Christine Alessi
BACKGROUND: Light transmission aggregometry (LTA) is considered as the gold standard for testing platelet function in the setting of both platelet disorders suspicion and response to antiplatelet therapy evaluation. LTA requires however specialized equipment, substantial blood sample volumes, is technically challenging and time-consuming. AIM: To evaluate an automated platelet aggregation method performed on a routine coagulation analyzer Sysmex CS-2000i. METHODS: 46 patients presenting a bleeding syndrome and 62 patients with acute coronary syndrome receiving dual antiplatelet therapy were studied in total...
September 29, 2017: Platelets
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