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Platelet Rich Plasma Therapy

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https://www.readbyqxmd.com/read/29324848/platelet-rich-plasma-to-treat-experimentally-induced-skin-wounds-in-animals-a-systematic-review-and-meta-analysis
#1
Adolfo Maria Tambella, Anna Rita Attili, Gilles Dupré, Andrea Cantalamessa, Stefano Martin, Vincenzo Cuteri, Sabrina Marcazzan, Massimo Del Fabbro
The objective of the study was to review current literature to determine whether the topical application of platelet-rich plasma (PRP) promotes healing in experimentally-induced full-thickness skin wounds in animals. The hypothesis was that the adjunct of PRP has a positive effect on wound healing. An electronic search was carried out on the following databases: Web of Science, Cochrane Library, PubMed, Research Gate, Cochrane Wounds Group, Veterinary Information Network. No publication date nor language restrictions were applied...
2018: PloS One
https://www.readbyqxmd.com/read/29320964/autologous-us-guided-prp-injection-versus-us-guided-focal-extracorporeal-shock-wave-therapy-for-chronic-lateral-epicondylitis-a-minimum-of-2-year-follow-up-retrospective-comparative-study
#2
Mattia Alessio-Mazzola, Ilaria Repetto, Besmir Biti, Roberto Trentini, Matteo Formica, Lamberto Felli
PURPOSE: To compare the efficacy of two independent groups of patients treated with ultrasound (US)-guided extracorporeal shock wave (ESW) therapy and with US-guided injection of platelet-rich plasma (PRP) for chronic lateral epicondylitis (LE) with a minimum of 2-year follow-up. METHODS: We retrospectively evaluated 63 patients treated for chronic LE (31 patients with autologous US-guided PRP injection and 32 patients with US-guided focal ESW therapy) from 2009 to 2014...
January 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29316139/stem-cell-therapy-in-refractory-perineal-crohn-s-disease-long-term-follow-up
#3
Claudio Wainstein, Rodrigo Quera, Daniela Fluxá, Udo Kronberg, Alejandro Conejero, Francisco López-Köstner, Claudio Jofre, Alejandro J Zarate
AIM: To describe the long-term outcomes of adipose-mesenchymal stem cells, platelet-rich plasma, and endorectal advancement flaps in patients with Perineal Crohn's Disease. METHOD: This was a single-center, prospective, observational pilot study performed between March 2013 and December 2016. The study included adult patients diagnosed with Perianal Crohn's Disease (with complex perianal fistulas) refractory to previous surgical and/or biological treatment. Patients underwent surgical treatment in two stages...
January 6, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29313321/the-matrix-synthesis-and-anti-inflammatory-effect-of-autologous-leukocyte-poor-platelet-rich-plasma-in-human-cartilage-explants
#4
Mario Simental-Mendía, Félix Vilchez-Cavazos, Rubén García-Garza, Jorge Lara-Arias, Roberto Montes-de-Oca-Luna, Salvador Said-Fernández, Herminia G Martínez-Rodríguez
OBJECTIVE: To determine the effects of autologous leukocyte-poor platelet-rich plasma (LP-PRP) on the expression of markers involved in cartilage-extracellular matrix production and inflammation in cartilage explants bearing osteoarthritis. MATERIALS AND METHODS: Cartilage explants and LP-PRP were obtained from 10 patients who underwent total knee arthroplasty. The explants were cultured in spinner flasks for 28 days in the presence of interleukin (IL)-1β and/or LP-PRP...
January 9, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29306567/platelet-rich-plasma-derived-scaffolds-increase-the-benefit-of-delayed-mesenchymal-stromal-cell-therapy-after-severe-traumatic-brain-injury
#5
Celia Bonilla Horcajo, Mercedes Zurita Castillo, Jesús Vaquero Crespo
BACKGROUND: Cell therapy using mesenchymal stromal cells (MSCs) offers new perspectives in the treatment of traumatic brain injury (TBI). The aim of the present study was to assess the impact of platelet-rich plasma scaffolds (PRPS) as support of MSCs in a delayed phase after severe TBI in rats. METHODS: TBI was produced by weight-drop impact to the right cerebral hemisphere. Two months after TBI, four experimental groups were established; saline, PRPS, MSCs in saline, or MSCs in PRPS was transplanted into the area of brain lesion through a small hole...
January 3, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29303234/platelet-rich-plasma-as-an-adjuvant-in-the-endometrial-preparation-of-patients-with-refractory-endometrium
#6
Aixa Molina, Jose Sánchez, William Sánchez, Vanessa Vielma
OBJECTIVE: To improve endometrial quality and implantation rates after the administration of platelet-rich plasma in patients with refractory endometrium. METHODS: 19 patients undergoing in vitro fertilization, aged between 33 and 45 years with a history of refractory endometrium, to whom platelet rich plasma was given by infusion with a catheter into the uterine cavity on the tenth day of the hormone replacement therapy, and then 72 hours after the first administration...
January 5, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29300106/advances-with-platelet-rich-plasma-therapies-for-tendon-regeneration
#7
Isabel Andia, Jose Ignacio Martin, Nicola Maffulli
PRPs can be used in the management of tendinopathy if we improve our understanding of pathophysiology and achieve to integrate molecular knowledge about PRP participation in healing mechanisms. Areas covered: We provide new insights into the pathophysiology of tendinopathy, PRP therapies, and the potential links between both. We discuss the place of PRP in promoting tendon repair within what is currently understood of the role of PRP molecules in promoting tendon regeneration. We also highlight the many opportunities for further exploration and identification of strategically designed treatments providing meaningful clinical benefit...
January 4, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29299496/effects-of-human-adipose-derived-stem-cells-and-platelet-rich-plasma-on-healing-response-of-canine-alveolar-surgical-bone-defects
#8
Reihaneh Shafieian, Maryam Moghaddam Matin, Amin Rahpeyma, Alireza Fazel, Hamideh Salari Sedigh, Ariane Sadr Nabavi, Halimeh Hassanzadeh, Alireza Ebrahimzadeh-Bideskan
Background: Due to the known disadvantages of autologous bone grafting, tissue engineering approaches have become an attractive method for ridge augmentation in dentistry. To the best of our knowledge, this is the first study conducted to evaluate the potential therapeutic capacity of PRP-assisted hADSCs seeded on HA/TCP granules on regenerative healing response of canine alveolar surgical bone defects. This could offer a great advantage to alternative approaches of bone tissue healing-induced therapies at clinically chair-side procedures...
November 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29297976/platelet-responses-to-pharmacological-and-physiological-interventions-in-middle-aged-men-with-different-habitual-physical-activity-levels
#9
M H Lundberg Slingsby, L Gliemann, M Thrane, N Rytter, J Egelund, M V Chan, P C Armstrong, T D Warner, Y Hellsten
The current guidelines following an acute coronary syndrome recommend dual anti-platelet therapy (aspirin plus a P2Y12 antagonist) alongside lifestyle modifications, including more regular physical activity. It is currently unknown if regular exercise affects the pharmacology of dual anti-platelet therapy. AIM: To explore how exercise-induced improvements in vascular and platelet function affect the efficacy of dual anti-platelet therapy, in a cross-sectional study of men with different physical activity level (training status)...
January 3, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29215166/effectiveness-of-platelet-rich-plasma-therapy-in-wound-healing-of-pilonidal-sinus-surgery-a-comprehensive-systematic-review-and-meta-analysis
#10
Shayan Mostafaei, Fatemeh Norooznezhad, Saeed Mohammadi, Amir Hossein Norooznezhad
BACKGROUND: Pilonidal disease (PD) is a chronic situation which may cause pain, discomfort, inflammation, discharges, and inability to do daily routines. Among two main methods of surgery, open healing is preferred by surgeons since it associates with lower risk of recurrence; however, it could complicate the wound condition by delaying the healing process. METHODS: For this meta-analysis, a search in Medline, Embase and Scopus was performed in June 2017 with no restrictions placed on the publication date or languages...
December 7, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29194786/microneedling-for-the-treatment-of-hair-loss
#11
REVIEW
Raymond M Fertig, A Caresse Gamret, Jessica Cervantes, Antonella Tosti
Microneedling is a minimally invasive dermatological procedure in which fine needles are rolled over the skin to puncture the stratum corneum. This therapy is used to induce collagen formation, neovascularization, and growth factor production of treated areas. It has been used in a wide range of dermatologic conditions, including androgenetic alopecia and alopecia areata, among others. While there are a limited number of studies examining this therapy in the use of hair loss, microneedling has been successfully paired with other hair growth promoting therapies, such as minoxidil, platelet rich plasma, and topical steroids, and shown to stimulate hair follicle growth...
December 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29194097/an-autologous-leukocyte-reduced-platelet-rich-plasma-therapy-for-chronic-injury-of-the-medial-collateral-ligament-in-the-knee-a-report-of-3-successful-cases
#12
Mamoru Yoshida, Keishi Marumo
Some patients complain of chronic persistent medial knee pain after isolated low-grade injuries of medial collateral ligaments (MCL). These injuries often respond to various conservative treatments but insufficient healing of ligaments is believed to be responsible for symptoms in this group of patients. We report on successful treatment of chronically symptomatic MCL injuries in 3 patients using autologous leukocyte-reduced platelet-rich plasma (PRP) injections. There were 3 men with a mean age of 39.3 years and a mean disease duration of 10 months...
November 29, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29182584/adjuvant-biological-therapies-in-chronic-leg-ulcers
#13
REVIEW
Natalia Burgos-Alonso, Igone Lobato, Igone Hernández, Kepa San Sebastian, Begoña Rodríguez, Gontzal Grandes, Isabel Andia
Current biological treatments for non-healing wounds aim to address the common deviations in healing mechanisms, mainly inflammation, inadequate angiogenesis and reduced synthesis of extracellular matrix. In this context, regenerative medicine strategies, i.e., platelet rich plasmas and mesenchymal stromal cell products, may form part of adjuvant interventions in an integral patient management. We synthesized the clinical experience on ulcer management using these two categories of biological adjuvants. The results of ten controlled trials that are included in this systematic review favor the use of mesenchymal stromal cell based-adjuvants for impaired wound healing, but the number and quality of studies is moderate-low and are complicated by the diversity of biological products...
November 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29182042/greater-trochanteric-pain-syndrome-and-gluteus-medius-and-minimus-tendinosis-nonsurgical-treatment
#14
Ana Torres, Mariano Fernández-Fairen, José Sueiro-Fernández
Greater trochanteric pain syndrome (GTPS) affects 10-25% of people in developed countries. The underlying etiology for GTPS is most commonly the tendinosis or a tendon tear of the gluteus medius, minimus or both at the greater trochanter; the inflammation of the tendon is not a major feature. We critically evaluated conservative treatment, for which we reviewed 76 publications, grading them according to four levels of evidence. We identified a wide variety of conservative treatment options: home therapy (insoles, walking sticks/crutches, orthotic devices, stretching exercises and preventive measures); physiotherapy (massage and stretching exercises); infiltrations (corticosteroids and local anesthetics); image-guided infiltrations (fluoroscopy and ultrasound); shockwave therapy; platelet-rich plasma injection; and drug therapy...
January 2018: Pain Management
https://www.readbyqxmd.com/read/29177885/clopidogrel-therapy-in-patients-with-cardiovascular-disease-undergoing-transurethral-resection-of-the-prostate-a-step-towards-individualization
#15
Petros Tzimas, Maria Tsoumani, Dimitrios Giannakis, Kallirroi Kalantzi, Anastasios Petrou, Vasileios Chantzichristos, Nikolaos Sofikitis, Georgios Papadopoulos, Haralampos Milionis, Alexandros Tselepis
OBJECTIVES: The objective of this study was to test platelet function pre- and peri-operatively in clopidogrel-treated patients undergoing transurethral resection of the prostate. METHODS: This was a pilot study involving 20 male patients treated with clopidogrel (75 mg/day) for the secondary prevention of cardiovascular disease and scheduled for elective transurethral resection of the prostate. Platelet function testing with light transmittance aggregometry in platelet-rich plasma of four samples (T0, T1, T2, and T3 drawn on the same day, 3 and 7 days of clopidogrel cessation and 24-h post-operatively, respectively) was performed and evaluated in each patient...
November 25, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29165737/management-of-hemostasis-for-pediatric-patients-on-ventricular-assist-devices
#16
Iki Adachi, Vadim Kostousov, Lisa Hensch, Martin A Chacon-Portillo, Jun Teruya
Ventricular-assist devices (VADs) have seen increased utilization in the pediatric population. Formerly, this therapeutic modality was limited to only the pulsatile VAD, EXCOR (Berlin Heart GmbH). However, the continuous flow VAD devices, HeartMate II (Abbott Inc.) and HeartWare (Medtronic Inc.), are now increasingly used in this population. Postoperatively, VAD patients are acutely anticoagulated using unfractionated heparin, often beginning 24 to 48 hours after VAD placement. Once the patient is stabilized and ready to transition to a lower acuity or outpatient setting, low-molecular-weight heparin or warfarin therapy may be instituted...
November 17, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29164165/platelet-rich-plasma-for-primary-treatment-of-partial-ulnar-collateral-ligament-tears-mri-correlation-with-results
#17
J Banks Deal, Ed Smith, Wendell Heard, Michael J O'Brien, Felix H Savoie
Background: Jobe revolutionized the treatment of medial ulnar collateral ligament (MUCL) tears with his reconstruction technique. However, not all MUCL injuries require operative management; Rettig showed that 42% of MUCL injuries respond to conservative management. This was improved by Podesta, who showed that augmentation of nonoperative management with platelet-rich plasma (PRP) and magnetic resonance imaging (MRI) for detecting partial MUCL tears resulted in significantly higher success rates...
November 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29164105/platelet-rich-plasma-derived-growth-factors-contribute-to-stem-cell-differentiation-in-musculoskeletal-regeneration
#18
REVIEW
Yun Qian, Qixin Han, Wei Chen, Jialin Song, Xiaotian Zhao, Yuanming Ouyang, Weien Yuan, Cunyi Fan
Stem cell treatment and platelet-rich plasma (PRP) therapy are two significant issues in regenerative medicine. Stem cells such as bone marrow mesenchymal stem cells, adipose-derived stem cells and periodontal ligament stem cells can be successfully applied in the field of tissue regeneration. PRP, a natural product isolated from whole blood, can secrete multiple growth factors (GFs) for regulating physiological activities. These GFs can stimulate proliferation and differentiation of different stem cells in injury models...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29150935/generation-of-insulin-producing-cells-from-human-adipose-derived-mesenchymal-stem-cells-on-pva-scaffold-by-optimized-differentiation-protocol
#19
Seyed Ehsan Enderami, Masoud Soleimani, Yousef Mortazavi, Samad Nadri, Ali Salimi
The studies have been done on patient-specific human adipose-derived from mesenchymal stem cells (hADSCs) like a series of autologous growth factors and nanofibrous scaffolds (3D culture) will probably have many benefits for regenerative medicine in type 1 diabetes mellitus (TIDM) patients in the future. For this purpose, we established a polyvinyl alcohol (PVA) scaffold and a differentiation protocol by adding platelet-rich plasma (PRP) that induces the hADSCs into insulin-producing cells (IPCs). The Characteristics of the derived IPCs in 3D culture were compared with conventional culture (2D) groups evaluated at the mRNA and protein levels...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29141627/in-vitro-properties-of-concentrated-canine-platelets-stored-in-two-additive-solutions-a-comparative-study
#20
N Hlavac, C S Lasta, M L Dalmolin, L A Lacerda, D de Korte, N A Marcondes, S R Terra, F B Fernandes, F H D González
BACKGROUND: Platelet transfusion therapy poses many challenges in veterinary clinical practice. Lack of readily available blood donors, short shelf-life, and inability to administer a sufficient number of platelets to meet a dog's transfusion need are the major difficulties encountered. Platelet additive solutions are already in use at American and European human blood banks, showing to be a realistic alternative. This study compares the in vitro platelet function in plasma, Composol, or SSP+ during storage for 13 days...
November 15, 2017: BMC Veterinary Research
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