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Platelet Rich Plasma Therapy

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https://www.readbyqxmd.com/read/28809630/aplikace-plazmy-obohacen%C3%A3-o-trombocyty-a-leukocyty-k-later%C3%A3-ln%C3%A3-mu-epikondylu-humeru
#1
P Walder, L Paša, L Pavliska
PURPOSE OF THE STUDY The aim of the study was to evaluate the safety and efficacy of the application of platelet- and leukocyte-rich plasma (L-PRP) in the treatment of lateral humeral epicondyle (ERH) as compared to the administration of corticosteroid therapy. MATERIAL AND METHODS It was a prospective, double-blind and randomized clinical trial. It included a total of 25 cases of ERH in 23 patients aged 18 to 60 years. They were divided into two arms: L-PRP arm with 10 cases and corticosteroid arm with 15 cases...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28805478/production-of-platelet-rich-plasma-gel-from-elderly-patients-under-antithrombotic-drugs-perspectives-in-chronic-wounds-care
#2
M Velier, J Magalon, A Daumas, M Cassar, P Francois, A Ghazouane, C Philandrianos, B Bertrand, C Frere, D Bernot, P Villani, F Dignat George, F Sabatier
Platelet-Rich Plasma (PRP) is an autologous biological therapy obtained by centrifuging the patient's own blood to concentrate platelets. The addition of autologous thrombin and calcium chloride to PRP allows the production of a semi-solid form called PRP gel. PRP gel is increasingly used in a variety of tissue defects and predominantly in the management of non-healing chronic wounds. The topical application of PRP gel seems promising due to the capability of platelets to store and secrete growth factors (GF), fibrin and cytokines, which are essentials for wound healing...
August 14, 2017: Platelets
https://www.readbyqxmd.com/read/28800920/does-platelet-rich-plasma-lead-to-earlier-return-to-sport-when-compared-with-conservative-treatment-in-acute-muscle-injuries-a-systematic-review-and-meta-analysis
#3
Ujash Sheth, Tim Dwyer, Ira Smith, David Wasserstein, John Theodoropoulos, Sachdeep Takhar, Jaskarndip Chahal
PURPOSE: To compare the time to return to sport and reinjury rate after platelet-rich plasma (PRP) injection versus control therapy (i.e., physiotherapy or placebo injection) in patients with acute grade I or II muscle strains. METHODS: All eligible studies comparing PRP against a control in the treatment of acute (≤7 days) grade I or II muscle strains were identified. The primary outcome was time to return to play. The secondary outcome was the rate of reinjury at a minimum of 6 months of follow-up...
August 8, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28791607/treatment-of-dry-eye-disease-with-autologous-platelet-rich-plasma-a-prospective-interventional-non-randomized-study
#4
Jorge L Alio, Alejandra E Rodriguez, Renan Ferreira-Oliveira, Dominika Wróbel-Dudzińska, Ahmed A Abdelghany
INTRODUCTION: The objective of this study was to evaluate the use of autologous platelet-rich plasma (PRP) eye drops as monotherapy for the treatment of moderate to severe cases of dry eye disease. METHODS: Three hundred and sixty-eight patients with moderate to severe dry eye disease (DED) were included in this prospective case series. Subjects were classified as evaporative DED (EDED) or aqueous deficient DED (ADDED). Improvement of the DED subjective symptoms, corneal fluorescein staining (CFS), and corrected distance visual acuity (BCVA) were evaluated...
August 8, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28771982/original-article-platelet-rich-plasma-with-microneedling-in-androgenetic-alopecia-along-with-dermoscopic-pre-and-post-treatment-evaluation
#5
Abhijeet Kumar Jha, Uday Kumar Udayan, Prasoon Kumar Roy, Amar Kant Jha Amar, R K P Chaudhary
BACKGROUND: Platelet-rich plasma has shown beneficial effects in the treatment of androgenic alopecia with its growth factor properties in accelerating the dermal papilla. Dermoscopy is a noninvasive method that allows the in vivo evaluation of microstructures not visible to the naked eye. OBJECTIVE: To ascertain the role of platelet-rich plasma (PRP) with microneedling, and to compare the pre- and post-treatment dermoscopic features in androgenetic alopecia. (AGA)...
August 3, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28758836/contributions-for-classification-of-platelet-rich-plasma-proposal-of-a-new-classification-marspill
#6
Jose Fabio Santos Duarte Lana, Joseph Purita, Christian Paulus, Stephany Cares Huber, Bruno Lima Rodrigues, Ana Amélia Rodrigues, Maria Helena Santana, João Lopo Madureira, Ângela Cristina Malheiros Luzo, William Dias Belangero, Joyce Maria Annichino-Bizzacchi
Platelet-rich plasma (PRP) has emerged as a significant therapy used in medical conditions with heterogeneous results. There are some important classifications to try to standardize the PRP procedure. The aim of this report is to describe PRP contents studying celular and molecular components, and also propose a new classification for PRP. The main focus is on mononuclear cells, which comprise progenitor cells and monocytes. In addition, there are important variables related to PRP application incorporated in this study, which are the harvest method, activation, red blood cells, number of spins, image guidance, leukocytes number and light activation...
July 31, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28756518/ethics-evidence-based-sports-medicine-and-the-use-of-platelet-rich-plasma-in-the-english-premier-league
#7
M J McNamee, C M Coveney, A Faulkner, J Gabe
The use of platelet rich plasma (PRP) as a novel treatment is discussed in the context of a qualitative research study comprising 38 interviews with sports medicine practitioners and other stakeholders working within the English Premier League during the 2013-16 seasons. Analysis of the data produced several overarching themes: conservatism versus experimentalism in medical attitudes; therapy perspectives divergence; conflicting versions of appropriate evidence; subcultures; community beliefs/practices; and negotiation of medical decision-making...
July 29, 2017: Health Care Analysis: HCA: Journal of Health Philosophy and Policy
https://www.readbyqxmd.com/read/28755303/-degeneration-of-the-posterior-tibial-tendon-established-and-new-concepts
#8
REVIEW
Markus Walther
BACKGROUND: The most common cause of degeneration of the posterior tibial tendon is a congenital valgus deformity of the calcaneus. Other associated pathologies are forefoot supination, forefoot abduction and shortening of the gastrocnemius muscle. DIAGNOSTICS: Loaded x‑rays of the foot in three planes as well as the hindfoot alignment view enable evaluation of the axis of the foot under static loading conditions. The posterior tibial tendon can be imaged with ultrasound and magnetic resonance imaging (MRI)...
July 28, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28752097/efficacy-of-platelet-rich-plasma-in-retarding-intervertebral-disc-degeneration-a-meta-analysis-of-animal-studies
#9
Pei Li, Ruijie Zhang, Qiang Zhou
OBJECTIVES: Several animal studies have demonstrated the positive effects of platelet-rich plasma (PRP) on disc degeneration retardation. The present meta-analysis was to verify the efficacy of PRP in retarding disc degeneration in animal. METHODS: Relevant studies were identified and evaluated according to our inclusion and exclusion criteria. The standardized mean difference (SMD) and related 95% confidence interval (95% CI) were estimated to assess PRP efficiency...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28747619/comparison-of-commercially-available-blood-collection-tubes-containing-sodium-citrate-and-hirudin-in-platelet-aggregation-testing
#10
Walter J Janse van Rensburg, Patricia van der Merwe
BACKGROUND Platelet reactivity assessment is an important tool in both the causal determination of bleeding diathesis as well as in the evaluation of the efficacy of anti-platelet therapy in patients at risk of thrombosis. Sodium citrate is the most widely used anticoagulant for hemostasis investigations. However, some doubt exists over the suitability of sodium citrate in platelet function testing. Hirudin has been suggested as a superior replacement. Nevertheless, only 1 study compared citrated and hirudin treated samples with light transmission aggregometry...
July 27, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28733091/histological-analysis-of-the-association-of-low-level-laser-therapy-and-platelet-rich-plasma-in-regeneration-of-muscle-injury-in-rats
#11
Thiago Alves Garcia, Regina Celi Trindade Camargo, Tatiana Emy Koike, Guilherme Akio Tamura Ozaki, Robson Chacon Castoldi, José Carlos Silva Camargo Filho
OBJECTIVE: Muscle injuries are common, and their treatment requires costs and time off. Platelet rich plasma and low level laser therapy have been shown to be affordable and easy to use. The aim of this study was to evaluate the associated effects of low level laser therapy and platelet rich plasma on the treatment of the soleus muscle injured by strain in rats. METHODS: Thirty-five rats were randomly allocated into five groups: Control (C), Injury Control (IC), injury PRP (IP), injury LLLT (ILT) and injury LLLT and PRP (ILTP)...
July 4, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28721121/does-the-injection-of-platelet-rich-plasma-induce-changes-in-the-gene-expression-and-morphology-of-intact-thoroughbred-skeletal-muscle
#12
Kentaro Fukuda, Hirofumi Miyata, Atsutoshi Kuwano, Taisuke Kuroda, Norihisa Tamura, Yasumitsu Kotoyori, Yoshinori Kasashima
Platelet-rich plasma (PRP) therapy is promising for treating skeletal muscle injuries in human athletes by promoting muscle regeneration. It might also be useful for treating muscle injuries in equine athletes. In the present study, muscle regeneration induced by injection of PRP into intact muscle of Thoroughbred was investigated. Autologous PRP and saline were injected twice into intact left and right gluteus medius muscles of seven clinically healthy Thoroughbreds. Muscle samples were collected from the injection sites by needle biopsy at 2 and 7 days after PRP injection...
2017: Journal of Equine Science
https://www.readbyqxmd.com/read/28720875/ruthenium-conjugated-chrysin-analogues-modulate-platelet-activity-thrombus-formation-and-haemostasis-with-enhanced-efficacy
#13
Divyashree Ravishankar, Maryam Salamah, Alda Attina, Radhika Pothi, Thomas M Vallance, Muhammad Javed, Harry F Williams, Eman M S Alzahrani, Elena Kabova, Rajendran Vaiyapuri, Kenneth Shankland, Jonathan Gibbins, Katja Strohfeldt, Francesca Greco, Helen M I Osborn, Sakthivel Vaiyapuri
The constant increase in cardiovascular disease rate coupled with significant drawbacks of existing therapies emphasise the necessity to improve therapeutic strategies. Natural flavonoids exert innumerable pharmacological effects in humans. Here, we demonstrate the effects of chrysin, a natural flavonoid found largely in honey and passionflower on the modulation of platelet function, haemostasis and thrombosis. Chrysin displayed significant inhibitory effects on isolated platelets, however, its activity was substantially reduced under physiological conditions...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28719231/biologic-injections-for-osteoarthritis-and-articular-cartilage-damage-can-we-modify-disease
#14
Weilong J Shi, Fotios P Tjoumakaris, Mayan Lendner, Kevin B Freedman
OBJECTIVE: The purpose of the present investigation is to conduct a systematic review of the literature to review the clinical results of platelet rich plasma (PRP) and mesenchymal stem cell treatments (MSC) (biologics) for articular cartilage lesions and osteoarthritis of the knee. METHODS: A search of the PubMed, EMBASE, and Cochrane databases was performed to identify studies involving biologic therapy for osteoarthritis or osteochondral defects. Only Level I-III clinical trials with at least 3-month follow-up were included...
July 28, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/28717879/comparison-of-the-effect-of-activated-or-non-activated-prp-in-various-concentrations-on-osteoblast-and-fibroblast-cell-line-proliferation
#15
Surena Vahabi, Zahra Yadegari, Hossein Mohammad-Rahimi
Platelet-rich plasma (PRP) contains growth factors which positively affect cell proliferation, cell differentiation, chemotaxis and intracellular matrix synthesis. All these processes are involved in wound healing and tissue regeneration; thus, PRP as a source of growth factors can be used in periodontal regenerative therapies. The purpose of the present study was to assess the effect of various concentrations of activated and non-activated PRP on proliferation of osteoblasts and fibroblasts in vitro. PRP was obtained from three healthy volunteers...
July 17, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28717617/conservative-treatment-for-insertional-achilles-tendinopathy-platelet-rich-plasma-and-focused-shock-waves-a-retrospective-study
#16
Davide Erroi, Matilde Sigona, Tania Suarez, Donatella Trischitta, Antonio Pavan, Maria Chiara Vulpiani, Mario Vetrano
BACKGROUND: Insertional Achilles tendinopathy (IAT) represents a serious challenge for both physiatrists and surgeons. Here we analyse the results obtained by two conservative treatments [platelet-rich plasma (PRP) injections and focused extracorporeal shock-wave therapy (ESWT)] in physically active patients with IAT. METHODS: During two consecutive periods, 45 consecutive patients with IAT were treated with 3 sessions of ESWT (2400 impulses at 0.17-0.25 mJ/mm(2) per session) (24 cases between September 2011 and July 2013) or with 2 autologous PRP injections over two weeks (21 cases between September 2013 and July 2015)...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28717586/evaluating-platelet-aggregation-dynamics-from-laser-speckle-fluctuations
#17
Zeinab Hajjarian, Diane M Tshikudi, Seemantini K Nadkarni
Platelets are key to maintaining hemostasis and impaired platelet aggregation could lead to hemorrhage or thrombosis. We report a new approach that exploits laser speckle intensity fluctuations, emanated from a drop of platelet-rich-plasma (PRP), to profile aggregation. Speckle fluctuation rate is quantified by the speckle intensity autocorrelation, g2(t), from which the aggregate size is deduced. We first apply this approach to evaluate polystyrene bead aggregation, triggered by salt. Next, we assess dose-dependent platelet aggregation and inhibition in human PRP spiked with adenosine diphosphate and clopidogrel...
July 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28702979/use-of-platelet-rich-plasma-in-human-infertility
#18
G V L Colombo, V Fanton, D Sosa, E Criado Scholz, J Lotti, S E Aragona, T Lotti
Successful embryo implantation requires good quality embryo but also needs a receptive endometrium site. In our clinical practice, we daily verify that an adequate endometrial growth is reached for successful implantation. To understand whether platelet rich plasma (PRP) can improve endometrium thickness and performance, PRP treatment was carried out after at least three of the classic medical protocols currently in use had been unsuccessfully adopted. Eight patients with more than 3 cryo-transfers cancelled because of failure of endometrial growth, defined as endometrium less than 6 mm, with negative hysteroscopic screening for endometrial pathology, and with negative bacteriologic screening, before present and all previous treatment, were selected to undergo PRP treatment...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28697880/comparison-of-autologous-bone-marrow-and-adipose-tissue-derived-mesenchymal-stem-cells-and-platelet-rich-plasma-for-treating-surgically-induced-lesions-of-the-equine-superficial-digital-flexor-tendon
#19
A Romero, L Barrachina, B Ranera, A R Remacha, B Moreno, I de Blas, A Sanz, F J Vázquez, A Vitoria, C Junquera, P Zaragoza, C Rodellar
Several therapies have been investigated for equine tendinopathies, but satisfactory long term results have not been achieved consistently and a better understanding of the healing mechanism elicited by regenerative therapies is needed. The aim of this study was to assess the separate effects of autologous bone marrow (BM) and adipose tissue (AT) derived mesenchymal stem cells (MSCs), and platelet rich plasma (PRP), for treating lesions induced in the superficial digital flexor tendon (SDFT) of horses. Lesions were created surgically in both SDFTs of the forelimbs of 12 horses and were treated with BM-MSCs (six tendons), AT-MSCs (six tendons) or PRP (six tendons)...
June 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28670405/intradiscal-injection-of-autologous-platelet-rich-plasma-releasate-to-treat-discogenic-low-back-pain-a-preliminary-clinical-trial
#20
Koji Akeda, Kohshi Ohishi, Koichi Masuda, Won C Bae, Norihiko Takegami, Junichi Yamada, Tomoki Nakamura, Toshihiko Sakakibara, Yuichi Kasai, Akihiro Sudo
STUDY DESIGN: Preliminary clinical trial. PURPOSE: To determine the safety and initial efficacy of intradiscal injection of autologous platelet-rich plasma (PRP) releasate in patients with discogenic low back pain. OVERVIEW OF LITERATURE: PRP, which is comprised of autologous growth factors and cytokines, has been widely used in the clinical setting for tissue regeneration and repair. PRP has been shown in vitro and in vivo to potentially stimulate intervertebral disc matrix metabolism...
June 2017: Asian Spine Journal
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