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https://www.readbyqxmd.com/read/29036806/pritumumab-the-first-therapeutic-antibody-for-glioma-patients
#1
Ivan Babic, Elmar Nurmemmedov, Venkata M Yenugonda, Tiffany Juarez, Natsuko Nomura, Sandeep C Pingle, Mark C Glassy, Santosh Kesari
Immunotherapy is now at the forefront of cancer therapeutic development. Gliomas are a particularly aggressive form of brain cancer for which immunotherapy may hold promise. Pritumumab (also known in the literature as CLNH11, CLN-IgG, and ACA-11) was the first monoclonal antibody tested in cancer patients. Pritumumab is a natural human monoclonal antibody developed from a B lymphocyte isolated from a regional draining lymph node of a patient with cervical carcinoma. The antibody binds ecto-domain vimentin on the surface of cancer cells...
September 1, 2017: Human Antibodies
https://www.readbyqxmd.com/read/29035163/uptake-and-correlates-of-cervical-cancer-screening-among-hiv-infected-women-attending-hiv-care-in-uganda
#2
Rhoda K Wanyenze, John Baptist Bwanika, Jolly Beyeza-Kashesya, Shaban Mugerwa, Jim Arinaitwe, Joseph K B Matovu, Violet Gwokyalya, Dickson Kasozi, Justine Bukenya, Fred Makumbi
BACKGROUND: Human immunodeficiency virus (HIV)-infected women are at high risk of cervical cancer. OBJECTIVE: This study assessed uptake and correlates of cervical screening among HIV-infected women in care in Uganda. METHODS: A nationally representative cross-sectional survey of HIV-infected women in care was conducted from August to November 2016. Structured interviews were conducted with 5198 women aged 15-49 years, from 245 HIV clinics...
2017: Global Health Action
https://www.readbyqxmd.com/read/29034816/clinical-performance-of-loci%C3%A2-based-tumor-marker-assays-for-tumor-markers-ca-15-3-ca-125-cea-ca-19-9-and-afp-in-gynecological-cancers
#3
Ramona C Dolscheid-Pommerich, Mignon Keyver-Paik, Thomas Hecking, Walther Kuhn, Gunther Hartmann, Birgit Stoffel-Wagner, Stefan Holdenrieder
Evidence is sparse regarding the clinical performance of luminescent oxygen channeling immunoassays-based tumor marker assays in gynecological cancer. Analyzing serum samples of 336 patients with Dimension™Vista1500, we investigated the diagnostic power of carbohydrate antigen 15-3, carbohydrate antigen 125, carcinoembryonic antigen, carbohydrate antigen 19-9, and alpha-fetoprotein in patients suffering from different types of gynecological cancer and precancerous gynecological diseases and compared findings to appropriate control groups...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29034685/improving-performance-on-preventive-health-quality-measures-using-clinical-decision-support-to-capture-care-done-elsewhere-and-patient-exceptions
#4
Michael E Bowen, Deepa Bhat, Jason Fish, Brett Moran, Temple Howell-Stampley, Lynne Kirk, Stephen D Persell, Ethan A Halm
Preventive services required for performance measurement often are completed in outside health systems and not captured in electronic medical records (EMRs). A before-after study was conducted to examine the ability of clinical decision support (CDS) to improve performance on preventive quality measures, capture clinician-reported services completed elsewhere, and patient/medical exceptions and to describe their impact on quality measurement. CDS improved performance on colorectal cancer screening, osteoporosis screening, and pneumococcal vaccination measures ( P < ...
October 1, 2017: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/29034621/-circular-rnas-and-their-roles-in-tumorigenesis
#5
Yi Xie, Tianwen Li, Xiaoyan Mo, Junming Guo
Recently, with the development of RNA research techniques, a wide variety of circular RNAs (circRNAs) have been discovered and some of them are confirmed to have crucial biological functions. CircRNAs arise from exons (i.e. exonic circRNAs) or introns (i.e. intronic circRNAs). Acting as microRNA sponges or combining with proteins, circRNAs participate in the regulation of gene expression and influence the activity of some proteins. In addition, some circRNAs even encode proteins. More importantly, several circRNAs play a key role in the occurrence and progression of some tumors, including stomach, liver, colon, breast, cervical, and ovarian cancers...
November 25, 2016: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/29034308/cost-effectiveness-analysis-study-of-hpv-testing-as-a-primary-cervical-cancer-screening-in-thailand
#6
Wichai Termrungruanglert, Nipon Khemapech, Tanitra Tantitamit, Suleeporn Sangrajrang, Piyalamporn Havanond, Piyawat Laowahutanont
OBJECTIVES: The aim of this study is to compare the cost and benefit of four different cervical cancer screening strategies involving primary HPV 16/18 genotyping, hrHPV testing alone and cytology for detecting CIN2 +. METHODS: Economical analysis using Markov modeling approach to combine the epidemiological data from current population-based study of The National Cancer Institute of Thailand. A cohort of 100,000 hypothetical female population age 30-65 years was simulated in each strategy...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29034307/uterine-clostridium-perfringens-infection-related-to-gynecologic-malignancy
#7
Kevin M Kremer, Megan E McDonald, Michael J Goodheart
Uterine gas gangrene caused by Clostridium perfringens is a serious, often life-threatening infection that is rarely encountered in the practice of gynecologic oncology. However, the hypoxic nature of gynecologic cancers due to necrosis and/or prior radiation therapy creates a microenvironment optimal for proliferation of anaerobic bacteria such as the Clostridium species. Early recognition and aggressive treatment with IV antibiotics and surgical debridement remain the cornerstones of management in order to decrease morbidity and mortality...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29034117/correlates-of-cervical-cancer-screening-among-adult-latino-women-a-5-year-follow-up
#8
Patria Rojas, Tan Li, Gira J Ravelo, Christyl Dawson, Mariana Sanchez, Alicia Sneij, Weize Wang, Mariano Kanamori, Elena Cyrus, Mario R De La Rosa
BACKGROUND: Latinas have the highest incidence rates of cervical cancer in the United States, and Latinas in the United States are less likely to utilize cervical cancer screening. METHOD: We used secondary data analysis of a non-clinical convenience sample (n=316 women at baseline; n=285 at five-year follow-up) to examine correlates of cervical cancer screening among adult Latina women. Univariate and multiple logistic regression models using Generalized Estimated Equations (GEE) algorithm were utilized to assess the influence of the independent variables...
June 2017: World Medical & Health Policy
https://www.readbyqxmd.com/read/29033672/role-of-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-the-evaluation-of-head-and-neck-carcinoma
#9
REVIEW
Moheieldin M Abouzied, Ahmed Fathala, Abdulaziz Alsugair, Ahmad I Al Muhaideb, Mohammed H Al Qahtani
Fluorodeoxyglucose (FDG)-positron emission tomography-computed tomography (PET-CT) has been playing a pivotal role in tumor imaging for the past 20 years. Head and neck (HN) cancers are a good example that can illustrate such unique role of FDG imaging contributing to the patient's management. In this review article, we will describe the normal physiological distribution of FDG within HN structures focusing on its limitations and pitfalls. In addition, we will be also describing its role in the initial staging and restaging of the disease, particularly with regard to therapy response assessment...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29032751/development-in-drug-targeting-and-delivery-in-cervical-cancer
#10
Urvashi Aggarwal, Amit Kumar Goyal, Goutam Rath
Cervical cancer is the second most common cancer in women. Standard treatment options available for cervical cancer including chemotherapy, surgery and radiation therapy associated with their own side effects and toxicities. Tumor-targeted delivery of anticancer drugs is perhaps one of the most appropriate strategies to achieve optimal outcomes from treatment and improve quality of life. Recently nanocarriers based drug delivery systems owing to their unique properties have been extensively investigated for anticancer drug delivery...
October 9, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29032256/real-time-fluorescent-sentinel-lymph-node-mapping-with-icg-in-women-with-previous-conization-undergoing-laparoscopic-surgery-for-early-invasive-cervical-cancer-comparison-with-radiotracer-blue-dye
#11
Alessandro Buda, Andrea Papadia, Giampaolo Di Martino, Sara Imboden, Beatrice Bussi, Luca Guerra, Elena De Ponti, Claudio Reato, Maria Luisa Gasparri, Cinzia Crivellaro, Michael Mueller
STUDY OBJECTIVE: To evaluate the added value of fluorescence dye Indocyanine Green (ICG) for sentinel lymph node (SLN) mapping in women with cervical cancer who had undergone previous conization (stage 1A-1B1), by comparing ICG versus Tc99(m) radiotracer + blue-dye (BD). DESIGN: A retrospective study by two European centers (San Gerardo Hospital, Italy and University of Berne, Switzerland). CANADIAN TASK FORCE FOR CLASSIFICATION OF THE STUDY DESIGN: II - 2 SETTING: Two academic medical centers...
October 12, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29032160/multimodal-treatment-including-hysterectomy-improves-survival-in-patients-with-locally-advanced-cervical-cancer-a-population-based-propensity-score-matched-analysis
#12
San-Gang Wu, Wen-Wen Zhang, Jia-Yuan Sun, Feng-Yan Li, Zhen-Yu He, Juan Zhou
BACKGROUND: To evaluate the therapeutic value of multimodal treatment including hysterectomy in locally advanced cervical squamous cell carcinoma (SCC). METHODS: We retrospectively reviewed patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IIB-III cervical SCC between 2000 and 2013 using the Surveillance, Epidemiology, and End Results (SEER) program. Propensity score-matching was used to balance baseline characteristics of included patients...
October 12, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29031425/contents-of-japanese-pro-and-anti-hpv-vaccination-websites-a-text-mining-analysis
#13
Tsuyoshi Okuhara, Hirono Ishikawa, Masahumi Okada, Mio Kato, Takahiro Kiuchi
OBJECTIVE: In Japan, the human papillomavirus (HPV) vaccination rate has sharply fallen to nearly 0% due to sensational media reports of adverse events. Online anti-HPV-vaccination activists often warn readers of the vaccine's dangers. Here, we aimed to examine frequently appearing contents on pro- and anti-HPV vaccination websites. METHODS: We conducted online searches via two major search engines (Google Japan and Yahoo! Japan). Targeted websites were classified as "pro," "anti," or "neutral" according to their claims, with the author(s) classified as "health professionals," "mass media," or "laypersons...
September 23, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/29031179/carbosilane-metallodendrimers-based-on-copper-ii-complexes-synthesis-epr-characterization-and-anticancer-activity
#14
Natalia Sanz Del Olmo, Marta Maroto-Díaz, Rafael Gómez, Paula Ortega, Michela Cangiotti, M Francesca Ottaviani, F Javier de la Mata
A series of new organometallic carbosilane dendrimers functionalized with Copper(II) complex on the surface were synthesized and characterized as potential anticancer agents. These metallodendrimers were synthesized through the reaction of dendritic ligands containing N,N- and N,O- donor atoms able to act as chelating agents with CuCl2 as metallic ion precursor. The structural characterization of these complexes was addressed through the use of different analytical and spectroscopical techniques. Particularly, an electron paramagnetic resonance study was performed to corroborate the coordination properties of these dendritic ligands...
September 27, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29030179/designing-probe-from-e6-genome-region-of-human-papillomavirus-16-for-sensing-applications
#15
Nor Azizah Parmin, Uda Hashim, Subash C B Gopinath
Human Papillomavirus (HPV) is a standout amongst the most commonly reported over 100 types, among them genotypes 16, 18, 31 and 45 are the high-risk HPV. Herein, we designed the oligonucleotide probe for the detection of predominant HPV type 16 for the sensing applications. Conserved amino acid sequences within E6 region of the open reading frame in the HPV genome was used as the basis to design oligonucleotide probe to detect cervical cancer. Analyses of E6 amino acid sequences from the high-risk HPVs were done to check the percentage of similarity and consensus regions that cause different cancers, including cervical cancer...
October 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29030148/-robot-assisted-laparoscopic-radical-trachelectomy-for-early-stage-cervical-cancer-with-video
#16
S Motton, A Martinez, E Chantalat
No abstract text is available yet for this article.
October 10, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29030009/immunobiological-efficacy-and-immunotoxicity-of-novel-synthetically-prepared-fluoroquinolone-ethyl-6-fluoro-8-nitro-4-oxo-1-4-dihydroquinoline-3-carboxylate
#17
Soňa Jantová, Ema Paulovičová, Lucia Paulovičová, Michaela Janošková, Miroslav Pánik, Viktor Milata
The present study examined the cytotoxicity, anti-cancer reactivity, and immunomodulatory properties of new synthetically prepared fluoroquinolone derivative 6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (6FN) in vitro. The cytotoxicity/toxicity studies (concentrations in the range 1-100μM) are focused on the cervical cancer cells HeLa, murine melanoma cancer cells B16, non-cancer fibroblast NIH-3T3 cells and reconstructed human epidermis tissues EpiDerm™. The significant growth inhibition of cancer cells HeLa and B16 was detected...
October 6, 2017: Immunobiology
https://www.readbyqxmd.com/read/29029939/a-novel-therapeutic-vaccine-composed-of-a-rearranged-human-papillomavirus-type-16-e6-e7-fusion-protein-and-fms-like-tyrosine-kinase-3-ligand-induces-cd8-t-cell-responses-and-antitumor-effect
#18
Jianqiang Li, Si Chen, Jun Ge, Feng Lu, Sulin Ren, Zhiqiang Zhao, Xiuying Pu, Xiaoxiao Chen, Jiaojiao Sun, Yueqing Gu
The development of cervical cancer is mainly caused by infection with high risk genotypes of human papillomavirus, particularly type 16 (HPV16), which accounts for more than 50% of cervical cancer. The two early viral oncogenes, E6 and E7, are continuously expressed in cervical cancer cells and are necessary to maintain the malignant cellular phenotype, thus providing ideal targets for immunotherapy of cervical cancer. In this study, a novel vaccine strategy was developed based on a rationally shuffled HPV16 E6/E7 fusion protein, the addition of Fms-like tyrosine kinase-3 ligand (Flt3L) or the N domain of calreticulin (NCRT), and the usage of a CpG adjuvant...
October 10, 2017: Vaccine
https://www.readbyqxmd.com/read/29029626/higher-educational-attainment-associated-with-reduced-likelihood-of-abnormal-cervical-lesions-among-zambian-women-a-cross-sectional-study
#19
Twaambo Euphemia Hamoonga, Rosemary Ndonyo Likwa, Patrick Musonda, Charles Michelo
BACKGROUND: The high burden of cervical cancer in Zambia prompted the Ministry of Health and partners to develop the cervical cancer prevention program in Zambia (CCPPZ) in 2006. Despite this intervention more women continue to die from the disease and there is little understanding of factors that may be linked with abnormal cervical lesions in the general population. We therefore examined if educational attainment is associated with abnormal cervical lesions among Zambian women aged 15 to 49 years...
October 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29029517/prognostic-value-of-hpv-dna-status-in-cervical-cancer-before-treatment-a-systematic-review-and-meta-analysis
#20
Ping Li, Yue Tan, Li-Xia Zhu, Li-Na Zhou, Ping Zeng, Qin Liu, Min-Bin Chen, Ye Tian
BACKGROUND: Human papillomavirus (HPV), has been recognized as an vital preliminary event in the oncogenesis of cervical cancer. But the prognostic value is not well defined, because of past studies showing conflicting results. So we conducted this meta-analysis to evaluate whether HPV DNA status was associated with prognosis in cervical cancer. MATERIALS AND METHODS: A total of 17 previously published eligible studies including 2,838 cases were identified and included in this meta-analysis...
September 12, 2017: Oncotarget
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